[{"Gene":"AACS","Gene synonym":["ACSF1","FLJ12389","SUR-5"],"Ensembl":"ENSG00000081760","Gene description":"Acetoacetyl-CoA synthetase","Uniprot":["Q86V21"],"Chromosome":"12","Position":"125065434-125143333","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"95.6","Esophageal suprabasal cells":"95.0","Retinal ganglion cells":"170.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"170.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"16064369.4","intestine":"26470174.0","lymphoid tissue":"13279991.7","salivary gland":"19268554.0"},"Antibody":["HPA058815"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA058815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.57e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.14e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"}},{"Gene":"AADACL3","Gene synonym":[],"Ensembl":"ENSG00000188984","Gene description":"Arylacetamide deacetylase like 3","Uniprot":["Q5VUY0"],"Chromosome":"1","Position":"12716110-12728760","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"1.5","skin 1":"3.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1.1","Extravillous trophoblasts":"4.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1.1","Trophoblast cells":"4.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"2.1"},"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AANAT","Gene synonym":["SNAT"],"Ensembl":"ENSG00000129673","Gene description":"Aralkylamine N-acetyltransferase","Uniprot":["Q16613"],"Chromosome":"17","Position":"76453351-76470117","Protein class":["Enzymes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","Melatonin biosynthesis"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"10.2","testis":"4.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"50.3","Retinal bipolar cells":"175.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"43","RNA single cell type group specific nCPM":{"Neuronal cells":"175.9","Spermatogenic cell types":"50.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054321"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA054321":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AARSD1","Gene synonym":["AlaXp","MGC2744"],"Ensembl":"ENSG00000266967","Gene description":"Alanyl-tRNA synthetase domain containing 1","Uniprot":["Q9BTE6"],"Chromosome":"17","Position":"42950526-42964498","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Astrocytes":"18.3","Bergmann glia":"18.1","Brain excitatory neurons":"26.6","Brain inhibitory neurons":"29.5","Choroid plexus epithelial cells":"19.9","Ependymal cells":"14.2","Microglia":"14.5","Oligodendrocyte progenitor cells":"18.0","Oligodendrocytes":"14.4","Other brain neurons":"27.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"19.9","Glial cells":"18.3","Neuronal cells":"29.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":7,"Subcellular main location":["Nuclear membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021408":null,"HPA022869":null,"HPA023714":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.28e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"}},{"Gene":"AASDHPPT","Gene synonym":["AASD-PPT","ACPS","CGI-80","LYS5"],"Ensembl":"ENSG00000149313","Gene description":"Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase","Uniprot":["Q9NRN7"],"Chromosome":"11","Position":"106075501-106098699","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"450.4","Late primary spermatocytes":"193.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"450.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-3"}},{"Gene":"ABCA13","Gene synonym":["FLJ33876","FLJ33951"],"Ensembl":"ENSG00000179869","Gene description":"ATP binding cassette subfamily A member 13","Uniprot":[],"Chromosome":"7","Position":"48171458-48647497","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"bone marrow":"42.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Neutrophil progenitors":"4412.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neutrophils":"4412.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"45.7","hippocampal CA4":"97.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Squamous Cell Carcinoma (TCGA)":"9.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"5.2"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":1,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Centrosome","Basal body","Cytosol"],"Antibody RRID":{"HPA063601":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"}},{"Gene":"ABCB11","Gene synonym":["ABC16","BSEP","PFIC-2","PFIC2","PGY4","SPGP"],"Ensembl":"ENSG00000073734","Gene description":"ATP binding cassette subfamily B member 11","Uniprot":["O95342"],"Chromosome":"2","Position":"168915498-169031324","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":["Disease variant","Intrahepatic cholestasis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"liver":"75.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Hepatocytes":"309.0","M\u00fcller glia":"138.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"138.6","Hepatocytes":"309.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"74.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"112","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"28.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"1.8"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":1,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019035":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.37e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.89e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"}},{"Gene":"ABCC11","Gene synonym":["MRP8"],"Ensembl":"ENSG00000121270","Gene description":"ATP binding cassette subfamily C member 11","Uniprot":["Q96J66"],"Chromosome":"16","Position":"48165773-48247568","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"breast":"43.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"103.5","Cardiomyocytes":"554.5","Epicardial cells":"218.3","Epididymal efferent duct absorptive cells":"34.3","Melanocytes":"49.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"103.5","Barrier epithelial cells":"218.3","Myocytes":"554.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"9.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"17.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"breast cancer":"11.0","prostate cancer":"4.7"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 55: Breast - Lactation","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043100":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA071145":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.54e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.77e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ABCF2","Gene synonym":["ABC28","EST133090","HUSSY-18","M-ABC1"],"Ensembl":"ENSG00000033050","Gene description":"ATP binding cassette subfamily F member 2","Uniprot":["Q9UG63"],"Chromosome":"7","Position":"151211484-151227205","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Astrocytes":"10.2","Bergmann glia":"8.3","Brain excitatory neurons":"15.0","Brain inhibitory neurons":"14.6","Choroid plexus epithelial cells":"8.2","Ependymal cells":"8.9","Microglia":"7.3","Oligodendrocyte progenitor cells":"9.5","Oligodendrocytes":"11.2","Other brain neurons":"15.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"8.9","Glial cells":"11.2","Neuronal cells":"15.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020091","CAB020682","HPA021815","HPA030388"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3800","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":17,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB020682":null,"HPA020091":null,"HPA021815":null,"HPA030388":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.51e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.81e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"}},{"Gene":"ABCG4","Gene synonym":["WHITE2"],"Ensembl":"ENSG00000172350","Gene description":"ATP binding cassette subfamily G member 4","Uniprot":["Q9H172"],"Chromosome":"11","Position":"119149052-119162653","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"22.2","retina":"48.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"7.9","Brain inhibitory neurons":"8.7","Cone photoreceptor cells":"35.2","Epicardial cells":"4.5","Esophageal apical cells":"7.1","Other brain neurons":"8.2","Retinal amacrine cells":"4.8","Retinal bipolar cells":"10.2","Retinal horizontal cells":"8.0","Rod photoreceptor cells":"41.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"41.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"27.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"1.4"},"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA057635"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ABHD1","Gene synonym":["FLJ36128","LABH1"],"Ensembl":"ENSG00000143994","Gene description":"Abhydrolase domain containing 1","Uniprot":["Q96SE0"],"Chromosome":"2","Position":"27123789-27130812","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Serine esterase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"19.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"1933.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"102","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1933.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"7.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"1.0"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044390"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044390":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ABHD12B","Gene synonym":["BEM46L3","C14orf29"],"Ensembl":"ENSG00000131969","Gene description":"Abhydrolase domain containing 12B","Uniprot":["Q7Z5M8"],"Chromosome":"14","Position":"50872053-50904970","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"6.3","retina":"13.3","skin 1":"9.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"63.9","Epicardial cells":"63.7","M\u00fcller glia":"233.9","Oocytes":"41.4","Respiratory ciliated cells":"31.3","Retinal ganglion cells":"30.9","Rod photoreceptor cells":"53.1","Thymocytes":"29.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"63.9","Barrier epithelial cells":"63.7","Glial cells":"233.9","Neuronal cells":"53.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"29.7","thalamic excitatory":"39.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"eosinophil":"1.0","neutrophil":"2.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"2.2"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"cervical cancer":"5.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA002873":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ABHD16A","Gene synonym":["BAT5","D6S82E","NG26"],"Ensembl":"ENSG00000204427","Gene description":"Abhydrolase domain containing 16A, phospholipase","Uniprot":["O95870"],"Chromosome":"6","Position":"31686955-31703356","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Astrocytes":"14.6","Bergmann glia":"16.0","Brain excitatory neurons":"24.2","Brain inhibitory neurons":"21.2","Choroid plexus epithelial cells":"9.2","Ependymal cells":"17.0","Microglia":"20.5","Oligodendrocyte progenitor cells":"21.7","Oligodendrocytes":"24.3","Other brain neurons":"25.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"17.0","Glial cells":"24.3","Neuronal cells":"25.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":54,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA058606":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.51e-8"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"}},{"Gene":"ABHD2","Gene synonym":["LABH2"],"Ensembl":"ENSG00000140526","Gene description":"Abhydrolase domain containing 2, acylglycerol lipase","Uniprot":["P08910"],"Chromosome":"15","Position":"89087459-89202355","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase","Serine esterase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"128.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Foveolar cells":"670.3","Hepatocytes":"691.6","Late spermatids":"805.5","Neutrophils":"907.5","Oligodendrocyte progenitor cells":"642.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"907.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"620.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"70.0","neutrophil":"52.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate glandular cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1208","Protein cell type specific Intensity":{"Hepatocytes":"90598.7","Pancreas epithelial cells":"150980.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"7903","Protein tissue specific Intensity":{"liver":"1211241.9","pancreas":"369344.0"},"Antibody":["HPA005999"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol","Connecting piece","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":null,"Subcellular main location":["Cytosol","Flagellar centriole"],"Subcellular additional location":["Nucleoplasm","Connecting piece"],"Antibody RRID":{"HPA005999":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.47e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.89e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.75e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"}},{"Gene":"ABHD8","Gene synonym":["FLJ11743","MGC14280","MGC2512"],"Ensembl":"ENSG00000127220","Gene description":"Abhydrolase domain containing 8","Uniprot":["Q96I13"],"Chromosome":"19","Position":"17292131-17310236","Protein class":["Predicted intracellular proteins"],"Biological process":["Inflammatory response"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"99.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"254.7","Early spermatids":"147.5","Late primary spermatocytes":"201.8","Late spermatids":"496.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"254.7","Spermatogenic cell types":"496.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Fibroblasts","Skin - Keratinocyte (granular)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4916","Protein cell type specific Intensity":{"Proximal tubules":"491551.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037658","HPA058209"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA037658":null,"HPA058209":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"}},{"Gene":"ABITRAM","Gene synonym":["C9orf6","CG-8","FAM206A","FLJ20457","Simiate"],"Ensembl":"ENSG00000119328","Gene description":"Actin binding transcription modulator","Uniprot":["Q9NX38"],"Chromosome":"9","Position":"108934400-108950744","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"127.4","Respiratory ciliated cells":"63.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"127.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"81","Protein cell type specific Intensity":{"Granulosa cells":"8077.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035917","HPA035918"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Kinetochore","Cytokinetic bridge","Mitotic spindle","Primary cilium","Primary cilium tip","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":9,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Kinetochore","Cytokinetic bridge","Mitotic spindle","Primary cilium","Primary cilium tip"],"Antibody RRID":{"HPA035917":null,"HPA035918":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"}},{"Gene":"ABRA","Gene synonym":["STARS"],"Ensembl":"ENSG00000174429","Gene description":"Actin binding Rho activating protein","Uniprot":["Q8N0Z2"],"Chromosome":"8","Position":"106759483-106770244","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transcription","Transcription regulation","Translocation","Transport"],"Molecular function":["Actin-binding","Activator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"29.5","skeletal muscle":"135.7","tongue":"59.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"79.4","Late primary spermatocytes":"158.3","Myonuclei":"121.8","Thymic myoid cells":"134.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Myocytes":"121.8","Spermatogenic cell types":"158.3","Stromal cells":"134.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"1.7","vascular associated smooth muscle cell":"1.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"241","RNA cell line specific nTPM":{"Rhabdoid":"26.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Smooth muscle cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"609","Protein cell type specific Intensity":{"Skeletal myofibers":"60906.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"151","Protein tissue specific Intensity":{"skeletal muscle":"15089.5"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"730000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":15,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA004428":null,"HPA007569":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.55e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.02e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"}},{"Gene":"ACAT2","Gene synonym":[],"Ensembl":"ENSG00000120437","Gene description":"Acetyl-CoA acetyltransferase 2","Uniprot":["Q9BWD1"],"Chromosome":"6","Position":"159762045-159779112","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"216.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"213.9","Breast lactating cells":"235.5","Early spermatids":"247.6","Esophageal apical cells":"197.6","Esophageal basal cells":"184.4","Esophageal suprabasal cells":"223.5","Late spermatids":"190.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2500000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB021106":null,"HPA025736":null,"HPA025765":null,"HPA025811":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-5"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"}},{"Gene":"ACBD6","Gene synonym":["MGC2404"],"Ensembl":"ENSG00000230124","Gene description":"Acyl-CoA binding domain containing 6","Uniprot":["Q9BR61"],"Chromosome":"1","Position":"180269653-180502954","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Autism spectrum disorder","Disease variant","Dystonia","Intellectual disability","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"1377458.7"},"Antibody":["HPA028179","HPA028457"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA028179":null,"HPA028457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"ACBD7","Gene synonym":["bA455B2.2","FLJ38219"],"Ensembl":"ENSG00000176244","Gene description":"Acyl-CoA binding domain containing 7","Uniprot":["Q8N6N7"],"Chromosome":"10","Position":"15075475-15088776","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"69.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"33.0","Bergmann glia":"34.7","Endometrial ciliated cells":"12.1","Ependymal cells":"16.1","Epididymal efferent duct ciliated cells":"10.5","Fallopian tube ciliated cells":"15.0","Late primary spermatocytes":"15.6","Respiratory ciliated cells":"12.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"16.1","Glial cells":"34.7","Spermatogenic cell types":"15.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"31.9","Bergmann glia":"40.3","ependymal cell":"21.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"15.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"olfactory bulb":"17.6"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2674798.2","Microglia and Neuropil":"1464189.7","Neurons":"838012.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"14626140.8"},"Antibody":["HPA043326","HPA062478"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":2,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043326":null,"HPA062478":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"ACCSL","Gene synonym":[],"Ensembl":"ENSG00000205126","Gene description":"1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like","Uniprot":["Q4AC99"],"Chromosome":"11","Position":"44047981-44059977","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Melanocytes":"10.3","Platelets":"5.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Pigment cells":"10.3","Platelets":"5.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA065042":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACER3","Gene synonym":["APHC","FLJ11238","PHCA"],"Ensembl":"ENSG00000078124","Gene description":"Alkaline ceramidase 3","Uniprot":["Q9NUN7"],"Chromosome":"11","Position":"76860859-77026797","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":["Lipid metabolism","Sphingolipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Mast cells":"568.3","Neutrophil progenitors":"336.7","Neutrophils":"360.5","Oligodendrocytes":"400.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mast cells":"568.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"531.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"30360.5","Pancreas epithelial cells":"20920.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA070087"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA070087":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.30e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"}},{"Gene":"ACOT12","Gene synonym":["Cach","STARD15","THEAL"],"Ensembl":"ENSG00000172497","Gene description":"Acyl-CoA thioesterase 12","Uniprot":["Q8WYK0"],"Chromosome":"5","Position":"81329996-81394179","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Hydrolase","Serine esterase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"36","RNA tissue specific nTPM":{"liver":"94.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatic stellate cells":"12.9","Hepatocytes":"80.1","pDCs":"15.2","Renal collecting duct principal cells":"18.9","Thymocytes":"66.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"80.1","T-cells":"66.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"43","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"19.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"1.1"},"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"7377033.8","Hepatocytes":"26496547.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"46319","Protein tissue specific Intensity":{"liver":"4631873.1"},"Antibody":["HPA037723"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytokinetic bridge","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":8,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Cytokinetic bridge"],"Antibody RRID":{"HPA037723":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.92e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACOT13","Gene synonym":["HT012","THEM2"],"Ensembl":"ENSG00000112304","Gene description":"Acyl-CoA thioesterase 13","Uniprot":["Q9NPJ3"],"Chromosome":"6","Position":"24667035-24705065","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"28.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1133.8","Hepatocytes":"232.6","Late primary spermatocytes":"448.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1133.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"81409388.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"71150215.4"},"Antibody":["HPA019881","HPA057134"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8200","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":6,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA019881":null,"HPA057134":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.39e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.54e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"}},{"Gene":"ACOT7","Gene synonym":["ACH1","ACT","BACH","CTE-II","hBACH","LACH1","MGC1126"],"Ensembl":"ENSG00000097021","Gene description":"Acyl-CoA thioesterase 7","Uniprot":["O00154"],"Chromosome":"1","Position":"6264269-6393767","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Hydrolase","Serine esterase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"140.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"144.9","Enterocytes":"172.1","Goblet cells":"159.1","Late spermatids":"213.7","Mast cells":"161.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"213.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"NK-cell":"40.3","plasmacytoid DC":"35.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"35.8","NK-cells":"40.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Pituitary gland - Lactotropes","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"111713523.9","Microglia and Neuropil":"103913642.3","Neurons":"89231144.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"231681867.8"},"Antibody":["HPA025735","HPA025762"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"62000","Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA025735":null,"HPA025762":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.35e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.56e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"}},{"Gene":"ACOXL","Gene synonym":["FLJ11042"],"Ensembl":"ENSG00000153093","Gene description":"Acyl-CoA oxidase like","Uniprot":["Q9NUZ1"],"Chromosome":"2","Position":"110732539-111118548","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"6.8","lung":"8.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"753.4","Granulosa cells":"293.6","Papillary tip epithelial cells":"256.2","Plasma cells":"233.4","Prostatic club cells":"119.5","Prostatic glandular cells":"194.8","Transitional alveolar cells":"396.6","Undifferentiated spermatogonia":"125.5","Urothelial cells":"316.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"753.4","Barrier epithelial cells":"316.4","Plasma cells":"233.4","Renal nephron cells":"256.2","Reproductive supporting cells":"293.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"10.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"6.4"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035392","HPA035393"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA035392":null,"HPA035393":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-7"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.38e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.57e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"}},{"Gene":"ACR","Gene synonym":[],"Ensembl":"ENSG00000100312","Gene description":"Acrosin","Uniprot":["P10323"],"Chromosome":"22","Position":"50738196-50745339","Protein class":["Enzymes","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"testis":"80.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"30","RNA single cell type specific nCPM":{"Early spermatids":"37.3","Late primary spermatocytes":"22.3","Late spermatids":"70.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"50","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"70.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"7","RNA brain regional specific nTPM":{"choroid plexus":"5.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048687"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACRBP","Gene synonym":["CT23","OY-TES-1","SP32"],"Ensembl":"ENSG00000111644","Gene description":"Acrosin binding protein","Uniprot":["Q8NEB7"],"Chromosome":"12","Position":"6638075-6647433","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"20","RNA tissue specific nTPM":{"testis":"271.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"1191.4","Late primary spermatocytes":"1163.0","Late spermatids":"939.1","Platelets":"3356.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Platelets":"3356.0","Spermatogenic cell types":"1191.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"5.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"classical monocyte":"12.5","intermediate monocyte":"15.8","myeloid DC":"17.7","non-classical monocyte":"31.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"dendritic cells":"17.7","monocytes":"31.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"340","Protein tissue specific Intensity":{"bone marrow":"33998.6"},"Antibody":["HPA039081","HPA039082"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":5,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039081":null,"HPA039082":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"ACRV1","Gene synonym":["D11S4365","SP-10","SPACA2"],"Ensembl":"ENSG00000134940","Gene description":"Acrosomal vesicle protein 1","Uniprot":["P26436"],"Chromosome":"11","Position":"125671522-125680874","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"33","RNA tissue specific nTPM":{"testis":"110.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"66","RNA single cell type specific nCPM":{"Early spermatids":"1056.1","Late primary spermatocytes":"445.8","Late spermatids":"332.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"115","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1056.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038718","HPA038719"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Acrosome"],"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":3,"Subcellular main location":["Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA038718":null,"HPA038719":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACSBG2","Gene synonym":["BGR","DKFZp434K1635","PRTD-NY3"],"Ensembl":"ENSG00000130377","Gene description":"Acyl-CoA synthetase bubblegum family member 2","Uniprot":["Q5FVE4"],"Chromosome":"19","Position":"6135247-6193094","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Fatty acid metabolism","Lipid metabolism","Spermatogenesis"],"Molecular function":["Developmental protein","Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"274","RNA tissue specific nTPM":{"testis":"120.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"3180.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"47","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3180.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"41.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043421","HPA051013"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043421":null,"HPA051013":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACSL1","Gene synonym":["ACS1","FACL1","FACL2","LACS","LACS1","LACS2"],"Ensembl":"ENSG00000151726","Gene description":"Acyl-CoA synthetase long chain family member 1","Uniprot":["P33121"],"Chromosome":"4","Position":"184755595-184826818","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"680.0","liver":"1068.9","skeletal muscle":"697.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"13298.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"13298.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"266.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"neutrophil":"456.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"456.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Liver - Hepatocytes","Lung - Neutrophils_2","Prostate - Prostate glandular cells","Skin - Sebaceous gland cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"1043235457.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"551915842.4"},"Antibody":["HPA011316","HPA011317","HPA011964"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"63000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA011316":null,"HPA011317":null,"HPA011964":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.63e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.71e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"}},{"Gene":"ACSL5","Gene synonym":["ACS2","ACS5","FACL5"],"Ensembl":"ENSG00000197142","Gene description":"Acyl-CoA synthetase long chain family member 5","Uniprot":["Q9ULC5"],"Chromosome":"10","Position":"112374116-112428379","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Ligase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"211.6","intestine":"405.8","liver":"159.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"206.7","Endometrial ciliated cells":"185.0","Endometrial glandular cells":"606.6","Endometrial luminal cells":"265.4","Enterocytes":"943.9","Epididymal principal cells":"280.1","Urothelial cells":"449.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"449.6","Enterocytes":"943.9","Glandular cells":"606.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"116.0","leukocyte":"49.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Rectum Adenocarcinoma (TCGA)":"159.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"97.2","colorectal cancer":"99.3"},"RNA tissue cell type enrichment":["Breast - Endothelial cells","Heart muscle - Endothelial cells","Pituitary gland - Endothelial cells","Skeletal muscle - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"36439037.1","Hepatocytes":"77940581.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"167857492.6","liver":"156414197.2"},"Antibody":["HPA007162","CAB035986","CAB062546"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB035986":null,"CAB062546":null,"HPA007162":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.84e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"}},{"Gene":"ACSL6","Gene synonym":["ACS2","FACL6","KIAA0837","LACS2","LACS5"],"Ensembl":"ENSG00000164398","Gene description":"Acyl-CoA synthetase long chain family member 6","Uniprot":["Q9UKU0"],"Chromosome":"5","Position":"131949973-132012243","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"21.4","brain":"29.5","retina":"42.4","testis":"19.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"4.2","Bergmann glia":"3.5","Early spermatids":"1.5","Late primary spermatocytes":"5.3","Retinal amacrine cells":"1.4","Rod photoreceptor cells":"1.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"4.2","Neuronal cells":"1.6","Spermatogenic cell types":"5.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"4.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"4.6","Glioblastoma Multiforme (TCGA)":"6.9","Liver Hepatocellular Carcinoma (TCGA)":"3.0","Rectum Adenocarcinoma (TCGA)":"6.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory CD8 T-cell":"1.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"1.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Breast - T-cells","Heart muscle - Cardiomyocytes","Kidney - Ascending Loop of Henle cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"27166384.0","Microglia and Neuropil":"29383242.5","Neurons":"30020856.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"22270184.4"},"Antibody":["HPA040470"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040470":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACSM6","Gene synonym":["bA310E22.3","C10orf129"],"Ensembl":"ENSG00000173124","Gene description":"Acyl-CoA synthetase medium chain family member 6","Uniprot":["Q6P461"],"Chromosome":"10","Position":"95194200-95228929","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"2.9","pancreas":"2.9","skin 1":"1.5","stomach 1":"1.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"42.5","Cardiomyocytes":"28.1","Epicardial cells":"188.8","Retinal bipolar cells":"37.3","Rod photoreceptor cells":"76.8","Urothelial cells":"98.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"188.8","Neuronal cells":"76.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044593":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACTL6A","Gene synonym":["Actl6","Arp4","BAF53A","INO80K","SMARCN1"],"Ensembl":"ENSG00000136518","Gene description":"Actin like 6A","Uniprot":["O96019"],"Chromosome":"3","Position":"179562886-179588407","Protein class":["Disease related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Growth regulation","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"191.9","Late primary spermatocytes":"326.6","Oocytes":"308.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"308.5","Spermatogenic cell types":"326.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000","Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":123,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB012188":null,"HPA018671":null,"HPA063149":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.97e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.83e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"}},{"Gene":"ACTN3","Gene synonym":[],"Ensembl":"ENSG00000248746","Gene description":"Actinin alpha 3","Uniprot":["Q08043"],"Chromosome":"11","Position":"66546395-66563334","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"72","RNA tissue specific nTPM":{"skeletal muscle":"1567.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"29.7","Myonuclei":"46.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Myocytes":"46.3","Spermatogenic cell types":"29.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Rhabdoid":"5.5"},"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"898200690.2","Smooth muscle cells":"1411265980.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"306600142.0","skeletal muscle":"347174657.9","Stomach":"231138498.5"},"Antibody":["HPA006035"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Actin filaments","Focal adhesion sites","Primary cilium","Primary cilium transition zone","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"18000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":53,"Subcellular main location":["Actin filaments","Focal adhesion sites"],"Subcellular additional location":["Primary cilium","Primary cilium transition zone","Cytosol"],"Antibody RRID":{"HPA006035":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ACTR3C","Gene synonym":["ARP11"],"Ensembl":"ENSG00000106526","Gene description":"Actin related protein 3C","Uniprot":["Q9C0K3"],"Chromosome":"7","Position":"150243916-150323725","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"53.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"132.3","Choroid plexus epithelial cells":"155.1","Distal convoluted tubule cells":"212.7","Loop of henle epithelial cells":"159.4","Renal collecting duct intercalated cells":"169.8","Renal collecting duct principal cells":"143.6","Renal connecting tubule cells":"192.7","Retinal pigment epithelial cells":"144.9","Salivary ionocytes":"151.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"192.7","Renal nephron cells":"212.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"112.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"31.1"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":51,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042676":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.26e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":24,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038587":null,"HPA038588":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.53e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.92e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.51e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"}},{"Gene":"ACTR8","Gene synonym":["ARP8","INO80N"],"Ensembl":"ENSG00000113812","Gene description":"Actin related protein 8","Uniprot":["Q9H981"],"Chromosome":"3","Position":"53867066-53882152","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA recombination","DNA repair","Mitosis","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"59.6","Late spermatids":"133.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"133.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"56.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1463","Protein tissue specific Intensity":{"lymphoid tissue":"146254.7"},"Antibody":["HPA065236"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":39,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA065236":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol","Acrosome"],"Antibody RRID":{"HPA035817":null,"HPA035818":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA034944":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"}},{"Gene":"ADAD1","Gene synonym":["Tenr"],"Ensembl":"ENSG00000164113","Gene description":"Adenosine deaminase domain containing 1","Uniprot":["Q96M93"],"Chromosome":"4","Position":"122378966-122429802","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"185","RNA tissue specific nTPM":{"testis":"111.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"15","RNA single cell type specific nCPM":{"Early spermatids":"1044.3","Late primary spermatocytes":"967.8","Late spermatids":"1596.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1596.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"1.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Neuroblastoma":"2.3","thyroid cancer":"1.4"},"RNA tissue cell type enrichment":["Testis - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ADAM21","Gene synonym":["ADAM31"],"Ensembl":"ENSG00000139985","Gene description":"ADAM metallopeptidase domain 21","Uniprot":["Q9UKJ8"],"Chromosome":"14","Position":"70417107-70460427","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"56.4","Cardiomyocytes":"34.7","Early spermatids":"96.2","Late primary spermatocytes":"53.2","Late spermatids":"224.6","Myonuclei":"33.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adipocytes":"56.4","Spermatogenic cell types":"224.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ADAM29","Gene synonym":["CT73","svph1"],"Ensembl":"ENSG00000168594","Gene description":"ADAM metallopeptidase domain 29","Uniprot":["Q9UKF5"],"Chromosome":"4","Position":"174829668-174978180","Protein class":["Disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"78","RNA tissue specific nTPM":{"testis":"38.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"37","RNA single cell type specific nCPM":{"Early spermatids":"500.5","Late primary spermatocytes":"273.1","Late spermatids":"438.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"46","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"500.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"hypothalamus":"1.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ADAM30","Gene synonym":["svph4"],"Ensembl":"ENSG00000134249","Gene description":"ADAM metallopeptidase domain 30","Uniprot":["Q9UKF2"],"Chromosome":"1","Position":"119893533-119896515","Protein class":["Plasma proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"243","RNA tissue specific nTPM":{"testis":"24.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"67.3","Late primary spermatocytes":"148.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"170","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"148.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA026080":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA044156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"}},{"Gene":"ADAM7","Gene synonym":["EAPI","GP-83"],"Ensembl":"ENSG00000069206","Gene description":"ADAM metallopeptidase domain 7","Uniprot":["Q9H2U9"],"Chromosome":"8","Position":"24440930-24526970","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"237","RNA tissue specific nTPM":{"epididymis":"3519.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Epididymal principal cells":"3360.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"3360.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"10.7","mammillary body":"16.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"1.7","Prostate Adenocarcinoma (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"22","RNA cell line specific nTPM":{"prostate cancer":"2.5"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA008879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043441":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"}},{"Gene":"ADCY10","Gene synonym":["HCA2","RP1-313L4.2","SAC","SACI","Sacy"],"Ensembl":"ENSG00000143199","Gene description":"Adenylate cyclase 10","Uniprot":["Q96PN6"],"Chromosome":"1","Position":"167809386-167914215","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["cAMP biosynthesis"],"Molecular function":["Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"liver":"5.7","testis":"16.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"111.8","Late primary spermatocytes":"88.3","Late spermatids":"133.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"133.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"3.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015243":null,"HPA017749":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ADCY8","Gene synonym":["AC8","ADCY3","HBAC1"],"Ensembl":"ENSG00000155897","Gene description":"Adenylate cyclase 8","Uniprot":["P40145"],"Chromosome":"8","Position":"130780301-131040909","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["cAMP biosynthesis"],"Molecular function":["Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"8.0","epididymis":"21.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"365.7","Brain excitatory neurons":"98.5","Brain inhibitory neurons":"131.2","Ependymal cells":"75.4","Epididymal efferent duct absorptive cells":"285.4","Epididymal principal cells":"100.9","Fallopian secretory cells":"62.2","Oligodendrocyte progenitor cells":"209.9","Retinal amacrine cells":"449.8","Retinal ganglion cells":"224.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"285.4","Glial cells":"365.7","Neuronal cells":"449.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"652.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"14.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"2.2","Rhabdoid":"1.1"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB018652":null,"HPA024291":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA044500":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"14000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020525":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039194":null,"HPA040437":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"ADRA2A","Gene synonym":["ADRA2","ADRA2R","ADRAR"],"Ensembl":"ENSG00000150594","Gene description":"Adrenoceptor alpha 2A","Uniprot":["P08913"],"Chromosome":"10","Position":"111077029-111080907","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"46.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"29.1","Cholangiocytes":"42.0","Endometrial glandular cells":"37.9","Epididymal efferent duct absorptive cells":"24.1","Megakaryocyte progenitors":"23.8","Pancreatic duct cells":"75.3","Pericytes":"51.1","Platelets":"118.5","Vascular smooth muscle cells":"156.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"75.3","Mural cells":"156.9","Platelets":"118.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"15.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"23.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"11.9"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"}},{"Gene":"ADRM1","Gene synonym":["ARM1","GP110","PSMD16","Rpn13"],"Ensembl":"ENSG00000130706","Gene description":"ADRM1 26S proteasome ubiquitin receptor","Uniprot":["Q16186"],"Chromosome":"20","Position":"62302093-62308862","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"376.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"2560.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2560.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"230000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":91,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042266":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.08e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"}},{"Gene":"ADSS1","Gene synonym":["ADSSL1","FLJ38602"],"Ensembl":"ENSG00000185100","Gene description":"Adenylosuccinate synthase 1","Uniprot":["Q8N142"],"Chromosome":"14","Position":"104724229-104747325","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Purine biosynthesis"],"Molecular function":["Ligase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"skeletal muscle":"1192.9","tongue":"569.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"478.1","Late primary spermatocytes":"297.4","Late spermatids":"127.5","M\u00fcller glia":"59.8","Myonuclei":"75.1","Thymic myoid cells":"205.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"478.1","Stromal cells":"205.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"55.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"123489525.2","Skeletal myofibers":"200844769.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"49167013.2","skeletal muscle":"120900479.7"},"Antibody":["HPA052621"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"150000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.35e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.03e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"}},{"Gene":"ADSS2","Gene synonym":["ADSS"],"Ensembl":"ENSG00000035687","Gene description":"Adenylosuccinate synthase 2","Uniprot":["P30520"],"Chromosome":"1","Position":"244408494-244451909","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Purine biosynthesis"],"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"215.1","Neutrophil progenitors":"726.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"726.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"72206948.6"},"Antibody":["HPA024400"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"500000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":15,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA024400":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"}},{"Gene":"ADTRP","Gene synonym":["AIG1L","C6orf105","dJ413H6.1"],"Ensembl":"ENSG00000111863","Gene description":"Androgen dependent TFPI regulating protein","Uniprot":["Q96IZ2"],"Chromosome":"6","Position":"11712054-11807046","Protein class":["Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"97.8","intestine":"92.7","parathyroid gland":"87.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"115.1","Colonocytes":"156.4","Early spermatids":"195.5","Enteric transient amplifying cells":"78.9","Enterocytes":"199.2","Foveolar cells":"166.3","Late primary spermatocytes":"97.1","Late spermatids":"372.1","Parietal cells":"104.3","Renal collecting duct intercalated cells":"208.6","Retinal pigment epithelial cells":"311.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"208.6","Enterocytes":"199.2","Gastric glandular cells":"166.3","Pigment cells":"311.2","Spermatogenic cell types":"372.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"111.0","deep-layer corticothalamic and 6b":"88.2","deep-layer near-projecting":"55.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"10","RNA brain regional specific nTPM":{"choroid plexus":"79.3"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"14.8","T-reg":"13.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"14.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Skin - Sebaceous gland cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048113"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":2,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA048113":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"}},{"Gene":"AFG1L","Gene synonym":["AFG1","LACE1"],"Ensembl":"ENSG00000135537","Gene description":"AFG1 like ATPase","Uniprot":["Q8WV93"],"Chromosome":"6","Position":"108294991-108526796","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"754.5","Late primary spermatocytes":"500.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"754.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"20915522.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"862944.7"},"Antibody":["HPA030154","HPA030155","HPA030659"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030154":null,"HPA030155":null,"HPA030659":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.59e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.33e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"}},{"Gene":"AGBL1","Gene synonym":["CCP4","FLJ32310"],"Ensembl":"ENSG00000273540","Gene description":"AGBL carboxypeptidase 1","Uniprot":["Q96MI9"],"Chromosome":"15","Position":"86079871-87049169","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Corneal dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"skeletal muscle":"7.0","tongue":"21.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"446.1","Ependymal cells":"1755.1","Gonadotrophs":"212.6","Myonuclei":"2287.5","Thymic myoid cells":"969.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1755.1","Myocytes":"2287.5","Stromal cells":"969.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"1756.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":"6","RNA pig brain regional specific nTPM":{"hippocampal formation":"6.1"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1496","Protein cell type specific Intensity":{"Skeletal myofibers":"149558.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"61","Protein tissue specific Intensity":{"skeletal muscle":"6118.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AGBL2","Gene synonym":["CCP2","FLJ23598"],"Ensembl":"ENSG00000165923","Gene description":"AGBL carboxypeptidase 2","Uniprot":["Q5U5Z8"],"Chromosome":"11","Position":"47659591-47715389","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"5.1","testis":"11.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Ependymal cells":"116.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"116.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"120.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Lung - Respiratory ciliated cells","Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"164082","Protein cell type specific Intensity":{"Keratinocytes":"16408236.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA007718"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Basal body","Cytosol","Flagellar centriole","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoli","Basal body","Cytosol","Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA007718":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AGBL3","Gene synonym":["CCP3","MGC32955"],"Ensembl":"ENSG00000146856","Gene description":"AGBL carboxypeptidase 3","Uniprot":["Q8NEM8"],"Chromosome":"7","Position":"134986508-135147963","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"7.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"129.0","Cardiomyocytes":"276.5","Early spermatids":"154.5","Ependymal cells":"120.1","Late primary spermatocytes":"169.9","Myonuclei":"131.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"276.5","Spermatogenic cell types":"169.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020397":null,"HPA024150":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AGBL4","Gene synonym":["CCP6","FLJ14442"],"Ensembl":"ENSG00000186094","Gene description":"AGBL carboxypeptidase 4","Uniprot":["Q5VU57"],"Chromosome":"1","Position":"48532854-50023954","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.5","choroid plexus":"3.5","retina":"4.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"1212.6","Choroid plexus epithelial cells":"2556.9","Cone photoreceptor cells":"2521.4","Corticotrophs":"1335.1","Endometrial ciliated cells":"1269.9","Ependymal cells":"2912.5","Gonadotrophs":"1182.2","Lactotrophs":"2467.3","Respiratory ciliated cells":"2874.0","Rod photoreceptor cells":"1201.3","Somatotrophs":"2794.1","Thyrotrophs":"3501.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2912.5","Neuronal cells":"2521.4","Pituitary endocrine cells":"3501.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"139452.4","Neurons":"448061.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4823","Protein tissue specific Intensity":{"cerebral cortex":"482263.1"},"Antibody":["HPA037994"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037994":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AGBL5","Gene synonym":["CCP5","FLJ21839"],"Ensembl":"ENSG00000084693","Gene description":"AGBL carboxypeptidase 5","Uniprot":["Q8NDL9"],"Chromosome":"2","Position":"27042364-27070622","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"parathyroid gland":"46.9","testis":"180.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"283.7","Late primary spermatocytes":"405.4","Late spermatids":"555.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"555.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Endothelial cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"268","Protein cell type specific Intensity":{"Fallopian tube cells":"25658.3","Macrophages":"27893.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030981"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Primary cilium","Centriolar satellite","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Cytokinetic bridge","Primary cilium"],"Subcellular additional location":["Microtubules","Centriolar satellite","Basal body"],"Antibody RRID":{"HPA030981":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.43e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"}},{"Gene":"AGFG1","Gene synonym":["HRB","RAB","RIP"],"Ensembl":"ENSG00000173744","Gene description":"ArfGAP with FG repeats 1","Uniprot":["P52594"],"Chromosome":"2","Position":"227472152-227561217","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","mRNA transport","Spermatogenesis","Transport"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"585.8","monocytes":"643.9","Neutrophil progenitors":"597.0","Neutrophils":"1538.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"643.9","Neutrophils":"1538.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"736.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Macrophages","Heart muscle - Macrophages","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"18725762.7","lymphoid tissue":"12509552.7"},"Antibody":["HPA008741"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"45000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA008741":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.29e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.48e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"}},{"Gene":"AGO4","Gene synonym":["EIF2C4","FLJ20033","hAGO4","KIAA1567"],"Ensembl":"ENSG00000134698","Gene description":"Argonaute RISC component 4","Uniprot":["Q9HCK5"],"Chromosome":"1","Position":"35808016-35857890","Protein class":["Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing","Translation regulation"],"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"372.1","Neutrophils":"795.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"795.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"7.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3693","Protein tissue specific Intensity":{"lymphoid tissue":"369310.1"},"Antibody":["CAB012179","HPA067849"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol","Cytoplasmic bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":30,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB012179":null,"HPA067849":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.14e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.20e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.55e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"AGPAT1","Gene synonym":["LPAAT-alpha","LPLAT1"],"Ensembl":"ENSG00000204310","Gene description":"1-acylglycerol-3-phosphate O-acyltransferase 1","Uniprot":["Q99943"],"Chromosome":"6","Position":"32168212-32178096","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"11.9","Bergmann glia":"12.4","Brain excitatory neurons":"17.8","Brain inhibitory neurons":"23.2","Ependymal cells":"20.0","Late spermatids":"10.8","Loop of henle epithelial cells":"9.1","Microglia":"9.0","Oligodendrocyte progenitor cells":"19.2","Oligodendrocytes":"21.9","Other brain neurons":"24.9","Papillary tip epithelial cells":"11.3","Platelets":"9.9","Podocytes":"9.5","Renal collecting duct principal cells":"11.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"20.0","Ductal cells":"11.3","Glial cells":"21.9","Neuronal cells":"24.9","Renal nephron cells":"11.3","Spermatogenic cell types":"10.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"hypothalamus":"65.3"},"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"9493167.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2101389.1","Stomach":"2424249.0"},"Antibody":["HPA048478","HPA073355"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Rods & Rings"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":151,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Rods & Rings"],"Antibody RRID":{"HPA048478":null,"HPA073355":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.14e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.64e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"}},{"Gene":"AGPAT3","Gene synonym":["LPAAT-gamma","LPAAT3","LPLAT3"],"Ensembl":"ENSG00000160216","Gene description":"1-acylglycerol-3-phosphate O-acyltransferase 3","Uniprot":["Q9NRZ7"],"Chromosome":"21","Position":"43865223-43987592","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"314.2","Late spermatids":"292.5","Rod photoreceptor cells":"322.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"9.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"24459567.8","Large ducts":"18326555.4","Proximal tubules":"73283880.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":20,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.42e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"}},{"Gene":"AGPAT4","Gene synonym":["dJ473J16.2","LPAAT-delta","LPAAT4","LPLAT4"],"Ensembl":"ENSG00000026652","Gene description":"1-acylglycerol-3-phosphate O-acyltransferase 4","Uniprot":["Q9NRZ5"],"Chromosome":"6","Position":"161129967-161274061","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"53.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"monocytes":"235.6","NK-cells":"213.0","Ocular epithelial cells":"186.1","Oligodendrocytes":"549.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"549.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"750.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2703335.6","Distal tubules":"1231510.7","Microglia and Neuropil":"2217859.7","Neurons":"3784196.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"23132","Protein tissue specific Intensity":{"cerebral cortex":"2313174.4"},"Antibody":["HPA053287","HPA060525"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":28,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoli","Vesicles"],"Antibody RRID":{"HPA053287":null,"HPA060525":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.78e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.83e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"}},{"Gene":"AGPAT5","Gene synonym":["FLJ11210","LPAAT-e","LPAAT-epsilon","LPLAT5"],"Ensembl":"ENSG00000155189","Gene description":"1-acylglycerol-3-phosphate O-acyltransferase 5","Uniprot":["Q9NUQ2"],"Chromosome":"8","Position":"6708642-6761503","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"19.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"70.7","Bergmann glia":"64.2","Brain excitatory neurons":"60.5","Brain inhibitory neurons":"67.6","Ependymal cells":"155.0","Microglia":"83.0","Oligodendrocyte progenitor cells":"76.0","Oligodendrocytes":"64.3","Other brain neurons":"75.3","Proximal tubule cells":"104.3","Renal collecting duct intercalated cells":"52.2","Renal connecting tubule cells":"46.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"155.0","Glial cells":"83.0","Neuronal cells":"75.3","Renal nephron cells":"104.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA010644","HPA010950","HPA011646"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA010644":null,"HPA010950":null,"HPA011646":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"AGR2","Gene synonym":["AG2","HAG-2","PDIA17","XAG-2"],"Ensembl":"ENSG00000106541","Gene description":"Anterior gradient 2, protein disulphide isomerase family member","Uniprot":["O95994"],"Chromosome":"7","Position":"16791811-16833433","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"600.4","intestine":"1148.3","stomach 1":"1323.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"5149.5","Endometrial secretory cells":"2331.3","Enteric stem cells":"1534.2","Enteric transient amplifying cells":"1667.4","Fallopian tube ciliated cells":"2564.8","Foveolar cells":"3724.5","Gastric chief cells":"2238.7","Gastric progenitor cells":"5670.1","Goblet cells":"6674.9","Mucous neck cells":"2518.9","Respiratory deuterosomal cells":"2354.2","Respiratory secretory cells":"3712.2","Submucosal glandular cells":"2000.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"3724.5","Goblet cells":"6674.9","Proliferating cells":"5670.1","Secretory cells":"3712.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Esophageal cancer":"605.6","Gastric cancer":"837.5"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Colon enterocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"87617888.2","Fallopian tube cells":"207683639.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1691119184.2","salivary gland":"423984305.9"},"Antibody":["HPA007912"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":296,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA007912":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.86e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.17e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.91e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"}},{"Gene":"AGTPBP1","Gene synonym":["CCP1","KIAA1035","Nna1"],"Ensembl":"ENSG00000135049","Gene description":"ATP\/GTP binding carboxypeptidase 1","Uniprot":["Q9UPW5"],"Chromosome":"9","Position":"85546539-85742029","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"56.8","retina":"43.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"676.9","Endometrial ciliated cells":"494.8","Monocyte progenitors":"524.3","monocytes":"517.7","Neutrophil progenitors":"1490.7","Neutrophils":"3053.4","Oligodendrocytes":"545.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"3053.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1180805.6","Microglia and Neuropil":"963147.4","Neurons":"1541321.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"655084.5","lymphoid tissue":"636895.8"},"Antibody":["HPA057208","HPA071094"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Primary cilium","Centriolar satellite","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Primary cilium","Centriolar satellite","Basal body"],"Antibody RRID":{"HPA057208":null,"HPA071094":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"AHCTF1","Gene synonym":["ELYS"],"Ensembl":"ENSG00000153207","Gene description":"AT-hook containing transcription factor 1","Uniprot":["Q8WYP5"],"Chromosome":"1","Position":"246839098-246931948","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Cell cycle","Cell division","mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"616.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"616.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"3.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"3495817.0","intestine":"9710664.3"},"Antibody":["HPA031658"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear membrane","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":24,"Subcellular main location":["Nucleoplasm","Nuclear membrane","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA031658":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.96e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"}},{"Gene":"AHCY","Gene synonym":["AdoHcyase","SAHH"],"Ensembl":"ENSG00000101444","Gene description":"Adenosylhomocysteinase","Uniprot":["P23526"],"Chromosome":"20","Position":"34280268-34311802","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"89.6","Esophageal apical cells":"49.6","Goblet cells":"40.6","Late primary spermatocytes":"53.9","Tuft cells":"103.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"89.6","Secretory gland support":"103.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"541617132.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041225","HPA044675"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7200000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":27,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041225":null,"HPA044675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-1"}},{"Gene":"AHI1","Gene synonym":["FLJ20069","JBTS3","ORF1"],"Ensembl":"ENSG00000135541","Gene description":"Abelson helper integration site 1","Uniprot":["Q8N157"],"Chromosome":"6","Position":"135283407-135498434","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation"],"Molecular function":["Developmental protein"],"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"25.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"1511.2","Corticotrophs":"1111.8","Gonadotrophs":"1277.8","Lactotrophs":"2085.0","Rod photoreceptor cells":"2047.6","Somatotrophs":"1928.7","Thyrotrophs":"2329.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"2047.6","Pituitary endocrine cells":"2329.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"9079","Protein cell type specific Intensity":{"Fallopian tube cells":"907939.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"11915","Protein tissue specific Intensity":{"lymphoid tissue":"1191456.3"},"Antibody":["HPA031698","HPA046684"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":10,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA031698":null,"HPA046684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"}},{"Gene":"AHRR","Gene synonym":["AHH","AHHR","bHLHe77","KIAA1234"],"Ensembl":"ENSG00000063438","Gene description":"Aryl hydrocarbon receptor repressor","Uniprot":[],"Chromosome":"5","Position":"321714-438291","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"22.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"142.0","Late primary spermatocytes":"168.0","Late spermatids":"93.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"168.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"63.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA021483":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AHSP","Gene synonym":["EDRF","ERAF"],"Ensembl":"ENSG00000169877","Gene description":"Alpha hemoglobin stabilizing protein","Uniprot":["Q9NZD4"],"Chromosome":"16","Position":"31527900-31528803","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"62","RNA tissue specific nTPM":{"bone marrow":"1571.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"50","RNA single cell type specific nCPM":{"Erythrocyte progenitors":"2430.9","Erythrocytes":"2026.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"55","RNA single cell type group specific nCPM":{"Erythrocytes":"2430.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"18","RNA cell line specific nTPM":{"Leukemia":"33.5"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3300000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040940":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AIM2","Gene synonym":["PYHIN4"],"Ensembl":"ENSG00000163568","Gene description":"Absent in melanoma 2","Uniprot":["O14862"],"Chromosome":"1","Position":"159061599-159187843","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","Immunity","Inflammatory response","Innate immunity"],"Molecular function":["DNA-binding"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"15.7","lymphoid tissue":"48.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"137.0","Choroid plexus epithelial cells":"170.8","Corticotrophs":"344.8","Gonadotrophs":"97.4","Lactotrophs":"201.3","Late spermatids":"63.3","Neutrophils":"104.0","Plasma cells":"67.6","Somatotrophs":"228.3","Thyrotrophs":"296.1","Urothelial cells":"76.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"137.0","Ciliated cells":"170.8","Neutrophils":"104.0","Pituitary endocrine cells":"344.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"153.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"31.9"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"7","RNA brain regional specific nTPM":{"choroid plexus":"19.3"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"memory B-cell":"146.1","naive B-cell":"64.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"146.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"47.8","Myeloma":"24.0"},"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA031365":null,"HPA040309":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.39e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.63e-4"}},{"Gene":"AIMP2","Gene synonym":["JTV-1","JTV1","p38","PRO0992"],"Ensembl":"ENSG00000106305","Gene description":"Aminoacyl tRNA synthetase complex interacting multifunctional protein 2","Uniprot":["Q13155"],"Chromosome":"7","Position":"6009255-6023834","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis","Differentiation","Protein biosynthesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"151.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"247.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"247.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019098","HPA020057"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"39000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":104,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019098":null,"HPA020057":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.46e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.30e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"}},{"Gene":"AIPL1","Gene synonym":["LCA4"],"Ensembl":"ENSG00000129221","Gene description":"Aryl hydrocarbon receptor interacting protein like 1","Uniprot":["Q9NZN9"],"Chromosome":"17","Position":"6393693-6435199","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Disease variant","Leber congenital amaurosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"215","RNA tissue specific nTPM":{"retina":"775.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Rod photoreceptor cells":"2243.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"44","RNA single cell type group specific nCPM":{"Neuronal cells":"2243.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"1.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"3.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"4.3","Uterine cancer":"6.6"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026578"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":24,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA026578":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AK7","Gene synonym":["CFAP75","FAP75","FLJ32864"],"Ensembl":"ENSG00000140057","Gene description":"Adenylate kinase 7","Uniprot":["Q96M32"],"Chromosome":"14","Position":"96392128-96489427","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"17.2","fallopian tube":"22.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"57.1","Endometrial ciliated cells":"167.3","Ependymal cells":"189.8","Epididymal efferent duct ciliated cells":"129.3","Fallopian tube ciliated cells":"216.5","Respiratory ciliated cells":"336.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"336.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"215.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"24","RNA blood cell specific nTPM":{"basophil":"9.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"31","RNA blood lineage specific nTPM":{"granulocytes":"9.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"11.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Lung - Respiratory ciliated cells","Skin - Keratinocyte (other)","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"130447","Protein cell type specific Intensity":{"Fallopian tube cells":"13044671.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"38723","Protein tissue specific Intensity":{"fallopian tube":"3872283.3"},"Antibody":["HPA003543"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA003543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.60e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.33e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"}},{"Gene":"AK8","Gene synonym":["C9orf98","FLJ32704"],"Ensembl":"ENSG00000165695","Gene description":"Adenylate kinase 8","Uniprot":["Q96MA6"],"Chromosome":"9","Position":"132725578-132878777","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"18.2","fallopian tube":"24.3","testis":"17.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"158.8","Endometrial ciliated cells":"101.4","Ependymal cells":"249.5","Epididymal principal cells":"74.4","Fallopian tube ciliated cells":"124.6","Late primary spermatocytes":"99.9","Late spermatids":"200.3","Respiratory ciliated cells":"323.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"323.5","Spermatogenic cell types":"200.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"261.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"31","RNA blood cell specific nTPM":{"memory B-cell":"6.2","naive B-cell":"5.0","NK-cell":"3.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"30","RNA blood lineage specific nTPM":{"B-cells":"6.2","NK-cells":"3.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"119144","Protein cell type specific Intensity":{"Fallopian tube cells":"11914409.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"142108","Protein tissue specific Intensity":{"fallopian tube":"14210811.2"},"Antibody":["HPA021443","HPA023894"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Flagellar centriole","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":20,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA021443":null,"HPA023894":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.06e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.55e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"}},{"Gene":"AK9","Gene synonym":["AKD1","AKD2","C6orf199","C6orf224","dJ70A9.1","FLJ25791","FLJ42177","MGC26954"],"Ensembl":"ENSG00000155085","Gene description":"Adenylate kinase 9","Uniprot":["Q5TCS8"],"Chromosome":"6","Position":"109492855-109691217","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Nucleotide metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"212.1","Early primary spermatocytes":"252.9","Endometrial ciliated cells":"207.6","Ependymal cells":"354.1","Fallopian tube ciliated cells":"209.9","Respiratory ciliated cells":"519.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"519.8","Spermatogenic cell types":"252.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"370.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Cytosol","Calyx"],"Antibody RRID":{"HPA030804":null,"HPA030805":null,"HPA031779":null,"HPA031781":null,"HPA036324":null,"HPA036711":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.39e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"AKAP12","Gene synonym":["AKAP250","SSeCKS"],"Ensembl":"ENSG00000131016","Gene description":"A-kinase anchoring protein 12","Uniprot":["Q02952"],"Chromosome":"6","Position":"151239967-151358559","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Calmodulin-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"750.0","Lymphatic endothelial cells":"1618.9","Melanocytes":"615.6","M\u00fcller glia":"1424.2","Ovarian stromal cells":"912.6","Pericytes":"619.1","Retinal ganglion cells":"571.7","Schwann cells":"958.6","Sertoli cells":"794.3","Smooth muscle cells":"885.7","Vascular endothelial cells":"657.5","Vascular smooth muscle cells":"684.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Endothelial cells":"1618.9","Glial cells":"1424.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"70.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"236","RNA blood cell specific nTPM":{"basophil":"37.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"236","RNA blood lineage specific nTPM":{"granulocytes":"37.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"78219199.5","Microglia and Neuropil":"73843973.1","Oocytes":"56251868.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"881233434.0"},"Antibody":["HPA006344","CAB026379","HPA056230"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3700000","Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":29,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB026379":null,"HPA006344":null,"HPA056230":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.92e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"}},{"Gene":"AKAP3","Gene synonym":["AKAP110","CT82","FSP95","SOB1"],"Ensembl":"ENSG00000111254","Gene description":"A-kinase anchoring protein 3","Uniprot":["O75969"],"Chromosome":"12","Position":"4615508-4649051","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"testis":"93.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"43","RNA single cell type specific nCPM":{"Early spermatids":"983.1","Late primary spermatocytes":"271.7","Late spermatids":"478.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"83","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"983.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"8.1","ependymal cell":"7.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"12.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Brain cancer":"5.7","testis cancer":"2.5"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039765","HPA073296"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol","Principal piece"],"Antibody RRID":{"HPA039765":null,"HPA073296":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"}},{"Gene":"AKAP6","Gene synonym":["ADAP6","AKAP100","KIAA0311","mAKAP","PRKA6"],"Ensembl":"ENSG00000151320","Gene description":"A-kinase anchoring protein 6","Uniprot":["Q13023"],"Chromosome":"14","Position":"32329298-32837684","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"51.1","skeletal muscle":"44.4","tongue":"47.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"563.8","Bergmann glia":"936.6","Brain excitatory neurons":"609.9","Brain inhibitory neurons":"761.9","Cardiomyocytes":"1494.9","Corticotrophs":"630.5","Myonuclei":"1324.5","Oligodendrocyte progenitor cells":"582.0","Oligodendrocytes":"1258.9","Other brain neurons":"651.0","Somatotrophs":"577.9","Thymic myoid cells":"959.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1258.9","Myocytes":"1494.9","Neuronal cells":"761.9","Stromal cells":"959.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"naive B-cell":"3.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"3.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"12.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Breast - Breast myoepithelial cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"9880195.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"4342951.9","heart muscle":"5316850.9"},"Antibody":["CAB001983","HPA048741"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB001983":null,"HPA048741":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.73e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.07e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.85e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"}},{"Gene":"AKNAD1","Gene synonym":["C1orf62","MGC26989"],"Ensembl":"ENSG00000162641","Gene description":"AKNA domain containing 1","Uniprot":["Q5T1N1"],"Chromosome":"1","Position":"108815898-108963484","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"4.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"37.1","Bergmann glia":"62.2","Brain excitatory neurons":"27.5","Brain inhibitory neurons":"33.1","Choroid plexus epithelial cells":"27.0","Early spermatids":"225.0","Ependymal cells":"35.5","Late primary spermatocytes":"70.7","Late spermatids":"35.9","Oligodendrocyte progenitor cells":"52.3","Oligodendrocytes":"50.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"62.2","Spermatogenic cell types":"225.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"1.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030270","HPA030271","HPA030272"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Microtubules","Cytokinetic bridge"],"Antibody RRID":{"HPA030270":null,"HPA030271":null,"HPA030272":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.81e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2500000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":4,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nucleoli fibrillar center","Endoplasmic reticulum"],"Antibody RRID":{"HPA044720":null,"HPA068265":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA057002":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AKR1E2","Gene synonym":["AKR1CL2","AKRDC1","htAKR","HTSP1","MGC10612"],"Ensembl":"ENSG00000165568","Gene description":"Aldo-keto reductase family 1 member E2","Uniprot":["Q96JD6"],"Chromosome":"10","Position":"4786629-4848062","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"17.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"79.3","Early spermatids":"228.1","Late primary spermatocytes":"101.9","Late spermatids":"258.0","Retinal ganglion cells":"50.2","Retinal horizontal cells":"54.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"258.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"17.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037822":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.72e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"}},{"Gene":"AKTIP","Gene synonym":["FLJ13258","FTS"],"Ensembl":"ENSG00000166971","Gene description":"AKT interacting protein","Uniprot":["Q9H8T0"],"Chromosome":"16","Position":"53491040-53504411","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"225.1","Esophageal apical cells":"129.8","Late spermatids":"494.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"494.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"9022913.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"80078.2"},"Antibody":["HPA041794","HPA046300"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Golgi apparatus","Plasma membrane","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":28,"Subcellular main location":["Nucleoli","Golgi apparatus","Basal body"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA041794":null,"HPA046300":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.77e-14"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"}},{"Gene":"ALDH1A2","Gene synonym":["RALDH2"],"Ensembl":"ENSG00000128918","Gene description":"Aldehyde dehydrogenase 1 family member A2","Uniprot":["O94788"],"Chromosome":"15","Position":"57953424-58497866","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"endometrium 1":"76.9","fallopian tube":"70.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"394.1","Endometrial stromal cells":"494.1","Epicardial cells":"1000.6","Hepatocytes":"403.1","Mesothelial cells":"344.1","M\u00fcller glia":"281.2","Neutrophils":"1959.1","Pituitary stem cells":"841.5","Prostatic club cells":"337.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1000.6","Neutrophils":"1959.1","Stem cells":"841.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"fibroblast":"435.4","hippocampal dentate gyrus":"1054.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"33.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"27.1"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"15","RNA blood cell specific nTPM":{"neutrophil":"32.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"62","RNA blood lineage specific nTPM":{"granulocytes":"32.8"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"31.9","liver cancer":"16.2"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal cortex cells","Pituitary gland - Lactotropes","Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"37173668.6","Fallopian tube cells":"90458668.5","Glomeruli":"25018867.1","Hepatocytes":"29786628.8","Oocytes":"69559367.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"17511366.3"},"Antibody":["HPA010022"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"350000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010022":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.11e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"}},{"Gene":"ALDH1L2","Gene synonym":["FLJ38508","mtFDH"],"Ensembl":"ENSG00000136010","Gene description":"Aldehyde dehydrogenase 1 family member L2","Uniprot":["Q3SY69"],"Chromosome":"12","Position":"105019784-105107643","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"pancreas":"38.3","salivary gland":"12.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Fibro-adipogenic progenitors":"70.1","Gonadotrophs":"64.8","Pancreatic acinar cells":"107.4","Pituitary stem cells":"61.8","Plasma cells":"74.7","Retinal ganglion cells":"46.4","Salivary acinar cells":"43.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"107.4","Fibro-adipogenic progenitors":"70.1","Plasma cells":"74.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"39.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Breast - Fibroblasts","Kidney - Fibroblasts","Minor Salivary Gland - Minor salivary glandular cells","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"575364097.7","Pancreas epithelial cells":"548253034.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"926386744.3"},"Antibody":["HPA039481","HPA059282"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA039481":null,"HPA059282":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"}},{"Gene":"ALG1","Gene synonym":["CDG1K","HMAT1","HMT-1","Mat-1"],"Ensembl":"ENSG00000033011","Gene description":"ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase","Uniprot":["Q9BT22"],"Chromosome":"16","Position":"5033702-5087379","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Congenital disorder of glycosylation","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"93.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"93.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"49038931.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA060392"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA060392":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"}},{"Gene":"ALG14","Gene synonym":["MGC19780"],"Ensembl":"ENSG00000172339","Gene description":"ALG14 UDP-N-acetylglucosaminyltransferase subunit","Uniprot":["Q96F25"],"Chromosome":"1","Position":"94974405-95072951","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Congenital myasthenic syndrome","Disease variant","Epilepsy","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"3474399.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"353","Protein tissue specific Intensity":{"liver":"24631.2","pancreas":"30466.8","salivary gland":"50810.4"},"Antibody":["HPA031829"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA031829":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"}},{"Gene":"ALG3","Gene synonym":["CDGS4","D16Ertd36e","Not56","NOT56L"],"Ensembl":"ENSG00000214160","Gene description":"ALG3 alpha-1,3- mannosyltransferase","Uniprot":["Q92685"],"Chromosome":"3","Position":"184242301-184249548","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Congenital disorder of glycosylation","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"115.3","Extravillous trophoblasts":"133.8","Late spermatids":"374.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"374.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Macrophages","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"3269329.1","Pancreatic islets":"2390838.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"279","Protein tissue specific Intensity":{"pancreas":"31301.5","salivary gland":"24486.5"},"Antibody":["HPA045103"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.60e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.32e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.50e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.02e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.02e-5"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA007989":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.56e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.25e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"}},{"Gene":"ALG9","Gene synonym":["DIBD1"],"Ensembl":"ENSG00000086848","Gene description":"ALG9 alpha-1,2-mannosyltransferase","Uniprot":["Q9H6U8"],"Chromosome":"11","Position":"111782195-111871581","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Congenital disorder of glycosylation","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"22.1","Bergmann glia":"26.3","Brain excitatory neurons":"29.5","Brain inhibitory neurons":"36.1","Choroid plexus epithelial cells":"30.2","Ependymal cells":"20.3","Microglia":"24.3","Oligodendrocyte progenitor cells":"26.7","Oligodendrocytes":"30.7","Other brain neurons":"33.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"30.2","Glial cells":"30.7","Neuronal cells":"36.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":4,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA038575":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"}},{"Gene":"ALK","Gene synonym":["ALK1","CD246"],"Ensembl":"ENSG00000171094","Gene description":"ALK receptor tyrosine kinase","Uniprot":["Q9UM73"],"Chromosome":"2","Position":"29192774-29921586","Protein class":["Cancer-related genes","CD markers","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Receptor","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"1.9","pituitary gland":"2.4","testis":"1.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"138.3","Brain inhibitory neurons":"202.5","Early spermatids":"228.9","Lactotrophs":"1017.9","Late spermatids":"260.6","Oligodendrocyte progenitor cells":"306.6","Retinal amacrine cells":"128.4","Salivary ionocytes":"417.3","Schwann cells":"321.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"321.2","Ionocytes":"417.3","Pituitary endocrine cells":"1017.9","Spermatogenic cell types":"260.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"876.2"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.1","Ovary Serous Cystadenocarcinoma (TCGA)":"1.2","Skin Cutaneous Melanoma (TCGA)":"2.9","Thyroid Carcinoma (TCGA)":"1.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Neuroblastoma":"84.2"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Enteric glia cells","Pituitary gland - Lactotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"52","Protein tissue specific Intensity":{"cerebral cortex":"5186.1"},"Antibody":["HPA010694"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":109,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA010694":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ALKBH3","Gene synonym":["DEPC-1"],"Ensembl":"ENSG00000166199","Gene description":"AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase","Uniprot":["Q96Q83"],"Chromosome":"11","Position":"43880811-43920274","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"131.3","Late spermatids":"130.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"131.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"164","Protein tissue specific Intensity":{"lymphoid tissue":"15482.8","pancreas":"14780.1","salivary gland":"18793.9"},"Antibody":["HPA009674","HPA046489"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA009674":null,"HPA046489":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"}},{"Gene":"ALKBH7","Gene synonym":["MGC10974","SPATA11"],"Ensembl":"ENSG00000125652","Gene description":"AlkB homolog 7","Uniprot":["Q9BT30"],"Chromosome":"19","Position":"6372794-6375250","Protein class":["Predicted intracellular proteins"],"Biological process":["Necrosis"],"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"518.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"2931.5","Late primary spermatocytes":"3371.1","Late spermatids":"13356.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"13356.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA008539":null,"HPA039571":null,"HPA039872":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.37e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"}},{"Gene":"ALLC","Gene synonym":["ALC"],"Ensembl":"ENSG00000151360","Gene description":"Allantoicase","Uniprot":["Q8N6M5"],"Chromosome":"2","Position":"3658200-3702671","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"testis":"15.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"178.5","Late primary spermatocytes":"93.4","Late spermatids":"42.0","Peritubular myoid cells":"16.5","Proximal tubule cells":"13.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"178.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"choroid plexus":"2.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"297","Protein tissue specific Intensity":{"intestine":"29833.8","liver":"29482.5"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ALMS1","Gene synonym":["KIAA0328"],"Ensembl":"ENSG00000116127","Gene description":"ALMS1 centrosome and basal body associated protein","Uniprot":["Q8TCU4"],"Chromosome":"2","Position":"73385758-73625166","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Cone-rod dystrophy","Deafness","Diabetes mellitus","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"20.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Respiratory ciliated cells":"258.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"6759166.3","Fallopian tube cells":"4417893.1","T-cells":"10322273.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"4821399.5"},"Antibody":["HPA035276","HPA043200"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Microtubules","Centrosome","Basal body","Cytosol","Flagellar centriole","Mid piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":17,"Subcellular main location":["Centrosome","Basal body","Cytosol","Flagellar centriole"],"Subcellular additional location":["Nucleoplasm","Microtubules","Mid piece","End piece"],"Antibody RRID":{"HPA035276":null,"HPA043200":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.26e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"}},{"Gene":"ALOX15","Gene synonym":["15-LOX-1"],"Ensembl":"ENSG00000161905","Gene description":"Arachidonate 15-lipoxygenase","Uniprot":["P16050"],"Chromosome":"17","Position":"4630919-4642294","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"35.2","fallopian tube":"12.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"35.2","Conjunctival goblet cells":"28.2","Epicardial cells":"45.5","Mesothelial cells":"106.1","Respiratory basal cells":"119.7","Respiratory ciliated cells":"277.9","Respiratory deuterosomal cells":"121.3","Respiratory secretory cells":"142.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"106.1","Basal cells":"119.7","Ciliated cells":"277.9","Secretory cells":"142.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"2.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"13.6","Lung Squamous Cell Carcinoma (TCGA)":"13.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"194","RNA blood cell specific nTPM":{"eosinophil":"608.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"194","RNA blood lineage specific nTPM":{"granulocytes":"608.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"24.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB004962":null,"CAB004963":null,"HPA013859":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.12e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":null,"Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":11,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus"],"Antibody RRID":{"HPA001598":null,"HPA018905":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":86,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB016281":null,"HPA019799":null,"HPA061282":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-6"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"}},{"Gene":"AMDHD2","Gene synonym":["CGI-14"],"Ensembl":"ENSG00000162066","Gene description":"Amidohydrolase domain containing 2","Uniprot":["Q9Y303"],"Chromosome":"16","Position":"2520357-2531422","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"52.0","Enterocytes":"54.9","Hofbauer cells":"223.4","Kupffer cells":"69.7","Late primary spermatocytes":"129.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"223.4","Spermatogenic cell types":"129.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"65000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":5,"Subcellular main location":["Nucleoli","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041184":null,"HPA041321":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"}},{"Gene":"AMER2","Gene synonym":["FAM123A","FLJ25477"],"Ensembl":"ENSG00000165566","Gene description":"APC membrane recruitment protein 2","Uniprot":["Q8N7J2"],"Chromosome":"13","Position":"25161679-25172288","Protein class":["Predicted intracellular proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"35.0","retina":"23.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Astrocytes":"131.8","Bergmann glia":"344.0","M\u00fcller glia":"278.9","Oligodendrocytes":"358.9","Retinal horizontal cells":"106.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Glial cells":"358.9","Neuronal cells":"106.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"astrocyte":"131.4","Bergmann glia":"341.1","committed oligodendrocyte precursor":"119.8","oligodendrocyte":"405.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"20","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"8.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bone cancer":"21.5"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"12982207.4","Microglia and Neuropil":"6439400.3","Neurons":"4556928.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"170364","Protein tissue specific Intensity":{"cerebral cortex":"17036407.8"},"Antibody":["HPA039458"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA039458":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AMFR","Gene synonym":["gp78","RNF45"],"Ensembl":"ENSG00000159461","Gene description":"Autocrine motility factor receptor","Uniprot":["Q9UKV5"],"Chromosome":"16","Position":"56361452-56425545","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ubl conjugation pathway","Wnt signaling pathway"],"Molecular function":["Receptor","Transferase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"235.7","Hepatocytes":"202.5","Platelets":"361.0","Renal collecting duct intercalated cells":"237.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"361.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"12524877.6","liver":"3348118.5","lymphoid tissue":"5833160.6"},"Antibody":["CAB026381","HPA029018","HPA064339","HPA077835"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":105,"Subcellular main location":["Endoplasmic reticulum","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB026381":null,"HPA029018":null,"HPA064339":null,"HPA077835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"}},{"Gene":"AMN1","Gene synonym":[],"Ensembl":"ENSG00000151743","Gene description":"Antagonist of mitotic exit network 1 homolog","Uniprot":["Q8IY45"],"Chromosome":"12","Position":"31671142-31729121","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"52.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"563.2","Late primary spermatocytes":"571.9","Late spermatids":"188.5","Neutrophils":"361.7","Rod photoreceptor cells":"218.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"218.4","Neutrophils":"361.7","Spermatogenic cell types":"571.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"52.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"860046.8","Pancreatic islets":"843074.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"10065","Protein tissue specific Intensity":{"cerebral cortex":"1006508.9"},"Antibody":["HPA046157","HPA062290"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA046157":null,"HPA062290":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.47e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"}},{"Gene":"AMOTL1","Gene synonym":["JEAP"],"Ensembl":"ENSG00000166025","Gene description":"Angiomotin like 1","Uniprot":["Q8IY63"],"Chromosome":"11","Position":"94706431-94876748","Protein class":["Predicted intracellular proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"104.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Medullary thymic epithelial cells":"225.6","Myonuclei":"391.0","Thymic myoid cells":"830.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"391.0","Stromal cells":"830.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"227.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"230","Protein cell type specific Intensity":{"Keratinocytes":"22991.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1468","Protein tissue specific Intensity":{"lung":"220098.7","lymphoid tissue":"73528.0"},"Antibody":["HPA001196"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cell Junctions","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9400","Blood expression cluster":null,"Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":25,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA001196":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.34e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.52e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"}},{"Gene":"AMZ2","Gene synonym":[],"Ensembl":"ENSG00000196704","Gene description":"Archaelysin family metallopeptidase 2","Uniprot":["Q86W34"],"Chromosome":"17","Position":"68205481-68257712","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"471.8","Choroid plexus epithelial cells":"277.8","Early spermatids":"499.4","Ependymal cells":"390.3","Late primary spermatocytes":"550.6","Late spermatids":"2072.4","M\u00fcller glia":"273.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2072.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"432.5","ependymal cell":"373.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"161557","Protein tissue specific Intensity":{"cerebral cortex":"16155739.7"},"Antibody":["HPA023299","HPA052406"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA023299":null,"HPA052406":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.09e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.10e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.98e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.90e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"}},{"Gene":"ANAPC10","Gene synonym":["APC10","DKFZP564L0562","DOC1"],"Ensembl":"ENSG00000164162","Gene description":"Anaphase promoting complex subunit 10","Uniprot":["Q9UM13"],"Chromosome":"4","Position":"144831908-145098541","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"105.7","Epicardial cells":"34.1","Late primary spermatocytes":"33.7","Loop of henle epithelial cells":"68.9","Papillary tip epithelial cells":"44.3","Podocytes":"88.0","Proximal tubule cells":"73.5","Renal collecting duct intercalated cells":"78.5","Renal collecting duct principal cells":"53.7","Renal connecting tubule cells":"78.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"34.1","Ductal cells":"78.7","Renal nephron cells":"105.7","Spermatogenic cell types":"33.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"44749.7","T-cells":"111841.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"811083.8","lymphoid tissue":"249603.2"},"Antibody":["HPA044547"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":45,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA044547":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"ANAPC11","Gene synonym":["APC11","Apc11p","HSPC214","MGC882"],"Ensembl":"ENSG00000141552","Gene description":"Anaphase promoting complex subunit 11","Uniprot":["Q9NYG5"],"Chromosome":"17","Position":"81890790-81900991","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"766.4","Extravillous trophoblasts":"655.6","Late primary spermatocytes":"854.1","Late spermatids":"1837.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1837.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA021989","HPA027838"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA021989":null,"HPA027838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.78e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.98e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"ANGEL1","Gene synonym":["Ccr4e","KIAA0759"],"Ensembl":"ENSG00000013523","Gene description":"Angel homolog 1","Uniprot":["Q9UNK9"],"Chromosome":"14","Position":"76786009-76826246","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"116.7","Late spermatids":"130.7","Microglia":"84.6","Oligodendrocyte progenitor cells":"116.7","Sertoli cells":"90.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"116.7","Reproductive supporting cells":"90.2","Spermatogenic cell types":"130.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Endothelial cells","Skin - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"91","Protein tissue specific Intensity":{"pancreas":"9072.3"},"Antibody":["HPA000948"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000948":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"ANK2","Gene synonym":["CFAP87","FAP87","LQT4"],"Ensembl":"ENSG00000145362","Gene description":"Ankyrin 2","Uniprot":["Q01484"],"Chromosome":"4","Position":"112818032-113384221","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Endocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Long QT syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"118.1","skeletal muscle":"120.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1654.3","Bergmann glia":"6456.2","Brain excitatory neurons":"1399.6","Brain inhibitory neurons":"1228.1","Ependymal cells":"1554.5","Myonuclei":"1069.4","Oligodendrocytes":"1582.7","Other brain neurons":"1483.3","Retinal ganglion cells":"2151.6","Retinal horizontal cells":"2652.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1554.5","Glial cells":"6456.2","Neuronal cells":"2652.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"6675.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"51.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"43.8","Rhabdoid":"31.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Colon - Enteric glia cells","Heart muscle - Cardiomyocytes","Liver - Hepatic stellate cells","Lung - Fibroblasts_2","Prostate - Fibroblasts","Spleen - Fibroblasts_1","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"423361422.4","Microglia and Neuropil":"520244937.1","Neurons":"144516326.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"871796207.5"},"Antibody":["HPA008007","CAB015178","HPA035970"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Acrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":40,"Subcellular main location":["Plasma membrane","Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"CAB015178":null,"HPA008007":null,"HPA035970":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.08e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.78e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"}},{"Gene":"ANKAR","Gene synonym":["FLJ25415"],"Ensembl":"ENSG00000151687","Gene description":"Ankyrin and armadillo repeat containing","Uniprot":["Q7Z5J8"],"Chromosome":"2","Position":"189674290-189761193","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"5.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Fibro-adipogenic progenitors":"220.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":null,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA036168":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANKEF1","Gene synonym":["ANKRD5","dJ839B4.6","FLJ21669"],"Ensembl":"ENSG00000132623","Gene description":"Ankyrin repeat and EF-hand domain containing 1","Uniprot":["Q9NU02"],"Chromosome":"20","Position":"9986126-10058303","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"13.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"429.6","Late spermatids":"552.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"552.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":10,"Subcellular main location":["Nucleoli fibrillar center","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041151":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"}},{"Gene":"ANKFN1","Gene synonym":["FLJ38335"],"Ensembl":"ENSG00000153930","Gene description":"Ankyrin repeat and fibronectin type III domain containing 1","Uniprot":["Q8N957"],"Chromosome":"17","Position":"55882301-56517016","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"8.3","fallopian tube":"4.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"191.5","Astrocytes":"339.8","Endometrial ciliated cells":"279.2","Ependymal cells":"809.6","Fallopian tube ciliated cells":"409.3","Papillary tip epithelial cells":"177.8","Prostatic club cells":"176.7","Respiratory ciliated cells":"918.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"918.4","Glial cells":"339.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"507.6","ependymal cell":"887.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.7","Liver Hepatocellular Carcinoma (TCGA)":"2.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"2.4"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA021566":null,"HPA022538":null,"HPA048953":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"}},{"Gene":"ANKLE2","Gene synonym":["KIAA0692","Lem4","LEMD7"],"Ensembl":"ENSG00000176915","Gene description":"Ankyrin repeat and LEM domain containing 2","Uniprot":["Q86XL3"],"Chromosome":"12","Position":"132725503-132761832","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":["Disease variant","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"344.9","Urothelial cells":"216.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"344.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2773812.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003602","HPA074838"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Endoplasmic reticulum","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":33,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA003602":null,"HPA074838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.27e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"}},{"Gene":"ANKMY1","Gene synonym":["FLJ20499","ZMYND13"],"Ensembl":"ENSG00000144504","Gene description":"Ankyrin repeat and MYND domain containing 1","Uniprot":["Q9P2S6"],"Chromosome":"2","Position":"240479422-240569209","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"30.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"296.1","Endometrial ciliated cells":"184.4","Ependymal cells":"295.7","Late primary spermatocytes":"169.5","Late spermatids":"350.9","Respiratory ciliated cells":"332.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"332.1","Spermatogenic cell types":"350.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"284.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"10096","Protein cell type specific Intensity":{"Fallopian tube cells":"1009644.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"34","Protein tissue specific Intensity":{"fallopian tube":"3434.0"},"Antibody":["HPA026620","HPA048869"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA026620":null,"HPA048869":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040705":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.95e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.01e-5"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"}},{"Gene":"ANKRD13A","Gene synonym":["ANKRD13","NY-REN-25"],"Ensembl":"ENSG00000076513","Gene description":"Ankyrin repeat domain 13A","Uniprot":["Q8IZ07"],"Chromosome":"12","Position":"109999186-110039763","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"258.2","Neutrophil progenitors":"229.4","Neutrophils":"571.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"571.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":41,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles","Primary cilium","Primary cilium tip","Primary cilium transition zone"],"Antibody RRID":{"HPA039488":null,"HPA043218":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.43e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"}},{"Gene":"ANKRD28","Gene synonym":["CFAP79","FAP79","KIAA0379","PITK","PP6-ARS-A","PPP1R65"],"Ensembl":"ENSG00000206560","Gene description":"Ankyrin repeat domain 28","Uniprot":["O15084"],"Chromosome":"3","Position":"15667236-15859771","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hematopoietic stem cells":"1189.8","Innate lymphoid cells":"861.0","Mast cells":"1229.0","Plasma cells":"3063.7","Thymocytes":"903.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Plasma cells":"3063.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"26","RNA blood cell specific nTPM":{"basophil":"17.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"26","RNA blood lineage specific nTPM":{"granulocytes":"17.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"11108008.5"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 78: Plasma cells - Antibody production & ER-stress response","Interactions":50,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane","Centrosome"],"Antibody RRID":{"HPA031655":null,"HPA031656":null,"HPA031657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":7,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA044008":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":30,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA051049":null,"HPA061649":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA029511":null,"HPA050732":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043489":null,"HPA052941":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANKS1B","Gene synonym":["AIDA-1","ANKS2","cajalin-2","EB-1"],"Ensembl":"ENSG00000185046","Gene description":"Ankyrin repeat and sterile alpha motif domain containing 1B","Uniprot":["Q7Z6G8"],"Chromosome":"12","Position":"98726457-99984936","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"66.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"2344.8","Brain inhibitory neurons":"2616.6","Oligodendrocyte progenitor cells":"2402.2","Oligodendrocytes":"1226.4","Other brain neurons":"1284.1","Retinal amacrine cells":"1086.5","Retinal ganglion cells":"772.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"2402.2","Neuronal cells":"2616.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"11.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA078230":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"}},{"Gene":"ANKS4B","Gene synonym":["FLJ38819","HARP"],"Ensembl":"ENSG00000175311","Gene description":"Ankyrin repeat and sterile alpha motif domain containing 4B","Uniprot":["Q8N8V4"],"Chromosome":"16","Position":"21233699-21253850","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"intestine":"11.9","kidney":"5.5","liver":"13.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Proximal tubule cells":"40.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Renal nephron cells":"40.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"6.5","medium spiny neuron":"6.2","upper rhombic lip":"8.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"8.3","Rectum Adenocarcinoma (TCGA)":"8.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"4.6","Gastric cancer":"3.3"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":2,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043523":null,"HPA061125":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.83e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.20e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANKUB1","Gene synonym":["C3orf16"],"Ensembl":"ENSG00000206199","Gene description":"Ankyrin repeat and ubiquitin domain containing 1","Uniprot":["A6NFN9"],"Chromosome":"3","Position":"149761100-149968385","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"3.1","fallopian tube":"5.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"367.0","Cardiomyocytes":"702.9","Early spermatids":"480.0","Endometrial ciliated cells":"425.5","Epicardial cells":"595.8","Fibro-adipogenic progenitors":"351.7","Myonuclei":"469.7","Respiratory ciliated cells":"450.4","Retinal ganglion cells":"305.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"595.8","Myocytes":"702.9","Spermatogenic cell types":"480.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"neutrophil":"1.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"1.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"1.6"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary gland ductal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053749"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053749":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANO3","Gene synonym":["C11orf25","DYT23","GENX-3947","TMEM16C"],"Ensembl":"ENSG00000134343","Gene description":"Anoctamin 3","Uniprot":["Q9BYT9"],"Chromosome":"11","Position":"26188842-26663289","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Dystonia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"20","RNA tissue specific nTPM":{"brain":"58.4","epididymis":"54.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"199.1","Brain excitatory neurons":"165.4","Brain inhibitory neurons":"405.4","Cone photoreceptor cells":"70.4","Epididymal principal cells":"202.3","Gonadotrophs":"61.3","Hepatic stellate cells":"284.0","Oligodendrocyte progenitor cells":"65.3","Pericytes":"96.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"199.1","Neuronal cells":"405.4","Reproductive supporting cells":"202.3","Stellate cells":"284.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"1104.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"1.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"basal ganglia":"129.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"12","RNA cell line specific nTPM":{"Rhabdoid":"8.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"basal ganglia":"158.9"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"7","RNA pig brain regional specific nTPM":{"basal ganglia":"211.0"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"409","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"49490.7","Microglia and Neuropil":"37014.7","T-cells":"36139.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1549","Protein tissue specific Intensity":{"cerebral cortex":"154900.0"},"Antibody":["HPA041629","CAB080586"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Mitotic spindle","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Microtubules","Primary cilium","Cytosol"],"Subcellular additional location":["Mitotic spindle","Basal body"],"Antibody RRID":{"CAB080586":null,"HPA041629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.03e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.02e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANO5","Gene synonym":["GDD1","LGMD2L","TMEM16E"],"Ensembl":"ENSG00000171714","Gene description":"Anoctamin 5","Uniprot":["Q75V66"],"Chromosome":"11","Position":"21782659-22283567","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Limb-girdle muscular dystrophy","Osteogenesis imperfecta"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"heart muscle":"22.7","parathyroid gland":"16.2","skeletal muscle":"61.5","tongue":"46.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cardiomyocytes":"469.5","Myonuclei":"1192.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Myocytes":"1192.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"7.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"4.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2151","Protein cell type specific Intensity":{"Cardiomyocytes":"215126.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA058857"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA058857":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANTKMT","Gene synonym":["C16orf24","FAM173A","MGC2494"],"Ensembl":"ENSG00000103254","Gene description":"Adenine nucleotide translocase lysine methyltransferase","Uniprot":["Q9BQD7"],"Chromosome":"16","Position":"720581-722590","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"217.3","Late primary spermatocytes":"423.5","Late spermatids":"785.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"785.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046262"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":10,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA046262":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"}},{"Gene":"ANTXRL","Gene synonym":[],"Ensembl":"ENSG00000274209","Gene description":"ANTXR like","Uniprot":["A6NF34"],"Chromosome":"10","Position":"46286345-46330207","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"12.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"70.6","Late primary spermatocytes":"41.2","Late spermatids":"50.1","Sertoli cells":"20.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"20.4","Spermatogenic cell types":"70.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"1.1"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"16278","Protein tissue specific Intensity":{"heart muscle":"1627766.3"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ANXA10","Gene synonym":["ANX14"],"Ensembl":"ENSG00000109511","Gene description":"Annexin A10","Uniprot":["Q9UJ72"],"Chromosome":"4","Position":"168092537-168187736","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"stomach 1":"459.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Foveolar cells":"1700.9","Gastric chief cells":"354.9","Gastric progenitor cells":"297.3","Mucous neck cells":"587.8","Pancreatic acinar cells":"185.3","Parietal cells":"705.4","Urothelial cells":"252.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Gastric glandular cells":"1700.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"114.2","Stomach Adenocarcinoma (TCGA)":"70.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"72.6","Gastric cancer":"50.4","pancreatic cancer":"55.5"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 68: Foveolar cells - Mucosal defense","Interactions":5,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA005469":null,"HPA074650":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.00e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"29000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":99,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045256":null,"HPA077258":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.66e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":23,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA054999":null,"HPA077258":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.26e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"}},{"Gene":"AP2B1","Gene synonym":["ADTB2","CLAPB1"],"Ensembl":"ENSG00000006125","Gene description":"Adaptor related protein complex 2 subunit beta 1","Uniprot":["P63010"],"Chromosome":"17","Position":"35578046-35726413","Protein class":["Cancer-related genes","Predicted intracellular proteins","Transporters"],"Biological process":["Endocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"613.2","Late spermatids":"1152.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1152.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"218971075.4","Microglia and Neuropil":"252149668.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"356540412.0"},"Antibody":["CAB017631","HPA056733","HPA067983"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"360000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":111,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB017631":null,"HPA056733":null,"HPA067983":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.98e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.43e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"AP3B2","Gene synonym":["NAPTB"],"Ensembl":"ENSG00000103723","Gene description":"Adaptor related protein complex 3 subunit beta 2","Uniprot":["Q13367"],"Chromosome":"15","Position":"82659281-82710112","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"46.0","parathyroid gland":"12.0","pituitary gland":"29.9","retina":"30.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"95.7","Brain excitatory neurons":"82.8","Brain inhibitory neurons":"71.8","Cone photoreceptor cells":"115.9","Corticotrophs":"100.7","Gonadotrophs":"156.0","Lactotrophs":"127.8","Neuroendocrine cells":"73.8","Other brain neurons":"70.4","Retinal bipolar cells":"104.3","Retinal horizontal cells":"68.1","Rod photoreceptor cells":"306.2","Somatotrophs":"103.5","Thyrotrophs":"106.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"95.7","Neuronal cells":"306.2","Pituitary endocrine cells":"156.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"10.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"23.2"},"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Prostate - Prostate basal glandular cells","Spleen - Neutrophils_2","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"37854480.2","Microglia and Neuropil":"51788385.4","Neurons":"47364114.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1","Protein tissue specific Intensity":{"cerebral cortex":"29320850.4"},"Antibody":["HPA039467","HPA039818"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":4,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA039467":null,"HPA039818":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"}},{"Gene":"AP3M2","Gene synonym":["AP47B","CLA20"],"Ensembl":"ENSG00000070718","Gene description":"Adaptor related protein complex 3 subunit mu 2","Uniprot":["P53677"],"Chromosome":"8","Position":"42152946-42171673","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"82.0","Late spermatids":"110.1","Melanocytes":"103.5","T-cells":"88.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pigment cells":"103.5","Spermatogenic cell types":"110.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"6738684.7","Microglia and Neuropil":"14208843.4","Neurons":"10862973.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"13920238.5"},"Antibody":["CAB014876","HPA045591","HPA048380"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB014876":null,"HPA045591":null,"HPA048380":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.77e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.54e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"}},{"Gene":"AP4M1","Gene synonym":["MU-4","MU-ARP2","SPG50"],"Ensembl":"ENSG00000221838","Gene description":"Adaptor related protein complex 4 subunit mu 1","Uniprot":["O00189"],"Chromosome":"7","Position":"100101549-100110345","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"78.9","Late primary spermatocytes":"81.7","Late spermatids":"134.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"134.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"1071301.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"81190.7","Stomach":"36428.6"},"Antibody":["HPA066774"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 18: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA066774":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.30e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.88e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"}},{"Gene":"AP4S1","Gene synonym":["AP47B","CLA20","SPG52"],"Ensembl":"ENSG00000100478","Gene description":"Adaptor related protein complex 4 subunit sigma 1","Uniprot":["Q9Y587"],"Chromosome":"14","Position":"31025106-31130996","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"448.9","Epicardial cells":"316.1","Myonuclei":"140.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"316.1","Myocytes":"448.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039963"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":5,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA039963":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.69e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.48e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"}},{"Gene":"AP5S1","Gene synonym":["C20orf29","FLJ11168"],"Ensembl":"ENSG00000125843","Gene description":"Adaptor related protein complex 5 subunit sigma 1","Uniprot":["Q9NUS5"],"Chromosome":"20","Position":"3820524-3828838","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["DNA damage","DNA repair","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"28.7","Platelets":"53.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"53.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"1134776.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"3986268.7"},"Antibody":["CAB034200","HPA043533","HPA048244"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":10,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB034200":null,"HPA043533":null,"HPA048244":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.04e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.87e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"}},{"Gene":"APH1B","Gene synonym":["APH-1B","DKFZp564D0372","PSFL"],"Ensembl":"ENSG00000138613","Gene description":"Aph-1 homolog B, gamma-secretase subunit","Uniprot":["Q8WW43"],"Chromosome":"15","Position":"63276018-63309126","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Notch signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"111.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"1354.0","Late primary spermatocytes":"2367.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2367.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"108.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"37793.8","Macrophages":"37479.8","Microglia and Neuropil":"70964.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.67e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.37e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"}},{"Gene":"APLF","Gene synonym":["C2orf13","MGC47799","Xip1","ZCCHH1"],"Ensembl":"ENSG00000169621","Gene description":"Aprataxin and PNKP like factor","Uniprot":["Q8IW19"],"Chromosome":"2","Position":"68467572-68655862","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"281.4","Late spermatids":"352.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"352.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"7.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"7.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"212107.0","Oocytes":"136446.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"23","Protein tissue specific Intensity":{"lymphoid tissue":"2349.4"},"Antibody":["HPA034642","HPA034643"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":23,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034642":null,"HPA034643":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"APOA5","Gene synonym":["APOA-V","RAP3"],"Ensembl":"ENSG00000110243","Gene description":"Apolipoprotein A5","Uniprot":["Q6Q788"],"Chromosome":"11","Position":"116789367-116792420","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"227","RNA tissue specific nTPM":{"liver":"568.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"387","RNA single cell type specific nCPM":{"Hepatocytes":"1587.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"387","RNA single cell type group specific nCPM":{"Hepatocytes":"1587.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"309","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"169.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"18","RNA cell line specific nTPM":{"liver cancer":"2.7"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"6580","Protein cell type specific Intensity":{"Collecting ducts":"439683.8","Glomeruli":"1105803.1","Hepatocytes":"798242.0","Proximal tubules":"288311.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"59048","Protein tissue specific Intensity":{"kidney":"2611530.3","liver":"9197986.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Apolipoprotein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":114000000,"Blood concentration - Conc. blood MS [pg\/L]":"16000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"APOBEC2","Gene synonym":["ARCD1","ARP1"],"Ensembl":"ENSG00000124701","Gene description":"Apolipoprotein B mRNA editing enzyme catalytic subunit 2","Uniprot":["Q9Y235"],"Chromosome":"6","Position":"41053202-41064891","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["mRNA processing"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"141.9","skeletal muscle":"799.8","tongue":"268.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"121.6","Extravillous trophoblasts":"29.5","Late primary spermatocytes":"34.4","Late spermatids":"32.5","Myonuclei":"107.7","Pancreatic duct cells":"35.1","Parietal cells":"166.2","Thymic myoid cells":"159.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Gastric glandular cells":"166.2","Myocytes":"121.6","Stromal cells":"159.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"10.4","choroid plexus epithelial cell":"10.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"4.1","Pancreatic Adenocarcinoma (TCGA)":"5.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9100","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA014252":null,"HPA017957":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"APOBEC4","Gene synonym":["C1orf169","FLJ25691","MGC26594","RP1-127C7.4"],"Ensembl":"ENSG00000173627","Gene description":"Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4","Uniprot":["Q8WW27"],"Chromosome":"1","Position":"183646275-183653316","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"fallopian tube":"10.9","testis":"9.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"28.8","Early spermatids":"143.5","Endometrial ciliated cells":"30.7","Epididymal efferent duct ciliated cells":"31.1","Fallopian tube ciliated cells":"87.6","Late primary spermatocytes":"88.8","Late spermatids":"116.2","Respiratory ciliated cells":"65.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"87.6","Spermatogenic cell types":"143.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":18000000000,"Blood concentration - Conc. blood MS [pg\/L]":"610000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"}},{"Gene":"APOL5","Gene synonym":["APOLV"],"Ensembl":"ENSG00000128313","Gene description":"Apolipoprotein L5","Uniprot":["Q9BWW9"],"Chromosome":"22","Position":"35717872-35729483","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"1.3","tongue":"1.9"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"APOM","Gene synonym":["Apo-M","G3a","NG20"],"Ensembl":"ENSG00000204444","Gene description":"Apolipoprotein M","Uniprot":["O95445"],"Chromosome":"6","Position":"31652416-31658210","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"liver":"448.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Hepatocytes":"693.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Hepatocytes":"693.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"83.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"3.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"6.4"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":7400000000,"Blood concentration - Conc. blood MS [pg\/L]":"2400000000","Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":14,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB034086":null,"HPA051006":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.67e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA077460":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.37e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AQP5","Gene synonym":[],"Ensembl":"ENSG00000161798","Gene description":"Aquaporin 5","Uniprot":["P55064"],"Chromosome":"12","Position":"49961872-49965682","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"salivary gland":"586.3","testis":"211.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"6777.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6777.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"3.0","oligodendrocyte precursor cell":"4.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"125.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"57.1","Gastric cancer":"24.2"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells (progenitors)","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2748","Protein cell type specific Intensity":{"Large ducts":"274774.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"8462456.5","salivary gland":"22521132.0"},"Antibody":["HPA065008"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":7,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA065008":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.90e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.22e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.60e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"}},{"Gene":"AQP7","Gene synonym":["AQP7L","AQP9","AQPap"],"Ensembl":"ENSG00000165269","Gene description":"Aquaporin 7","Uniprot":["O14520"],"Chromosome":"9","Position":"33383179-33402682","Protein class":["Essential proteins","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"200.1","breast":"87.3","heart muscle":"90.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"764.6","Cardiomyocytes":"449.9","Early spermatids":"141.0","Enterocytes":"191.1","Late primary spermatocytes":"92.5","Myonuclei":"175.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"764.6","Enterocytes":"191.1","Myocytes":"449.9","Spermatogenic cell types":"141.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"19.0","upper rhombic lip":"7.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Minor Salivary Gland - Adipocytes (Minor salivary gland)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048106"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Nuclear speckles","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Nuclear speckles"],"Antibody RRID":{"HPA048106":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.07e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.57e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"AREG","Gene synonym":["AR","AREGB","SDGF"],"Ensembl":"ENSG00000109321","Gene description":"Amphiregulin","Uniprot":["P15514"],"Chromosome":"4","Position":"74445136-74455005","Protein class":["Cancer-related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Cytokine","Growth factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"122.6","placenta":"308.9","urinary bladder":"135.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"3209.8","Breast hormone-responsive cells":"1337.5","cDC":"1501.6","Esophageal apical cells":"1903.7","Hematopoietic stem cells":"1321.3","Innate lymphoid cells":"3588.5","Mast cells":"5140.6","monocytes":"1830.5","NK-cells":"1412.3","Ocular epithelial cells":"2320.0","Thymocytes":"1815.0","Urothelial cells":"1489.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"3209.8","Innate lymphoid cells":"3588.5","Mast cells":"5140.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"17","RNA single nuclei brain specific nCPM":{"leukocyte":"41.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Rectum Adenocarcinoma (TCGA)":"166.5"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"3.2"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"basophil":"11.0","eosinophil":"11.8","NK-cell":"3.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"11.8","NK-cells":"3.8"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"543.3"},"RNA tissue cell type enrichment":["Colon - Neutrophils","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"olfactory bulb":"1.2"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008720","CAB023519"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB023519":null,"HPA008720":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.51e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.29e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.75e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.30e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"ARF1","Gene synonym":[],"Ensembl":"ENSG00000143761","Gene description":"ADP ribosylation factor 1","Uniprot":["P84077"],"Chromosome":"1","Position":"228082708-228099212","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1289.1","Platelets":"1412.8","Syncytiotrophoblasts":"897.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1289.1","Platelets":"1412.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"36","Protein cell type specific Intensity":{"Oocytes":"3588.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB007742"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"20000000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":35,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB007742":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"}},{"Gene":"ARFGEF3","Gene synonym":["BIG3","C6orf92","dJ171N11.1","KIAA1244","PPP1R33"],"Ensembl":"ENSG00000112379","Gene description":"ARFGEF family member 3","Uniprot":["Q5TH69"],"Chromosome":"6","Position":"138161939-138344663","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"20.1","salivary gland":"17.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"481.5","Neuroendocrine cells":"391.9","Oligodendrocytes":"480.8","Pancreatic islet cells":"489.5","Prostatic club cells":"349.1","Prostatic glandular cells":"625.8","Salivary acinar cells":"547.5","Somatotrophs":"610.5","Thyrotrophs":"391.6","Transitional alveolar cells":"461.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"547.5","Glandular cells":"625.8","Pituitary endocrine cells":"610.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"34.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"breast cancer":"13.8","prostate cancer":"45.9"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal medulla cells","Breast - Breast glandular cells","Liver - Vascular endothelial cells","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"21467071.4","Microglia and Neuropil":"26589863.8","Neurons":"32185308.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"43362451.7"},"Antibody":["HPA036350"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036350":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"}},{"Gene":"ARG2","Gene synonym":[],"Ensembl":"ENSG00000081181","Gene description":"Arginase 2","Uniprot":["P78540"],"Chromosome":"14","Position":"67619920-67651708","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Adaptive immunity","Arginine metabolism","Immunity","Innate immunity","Urea cycle"],"Molecular function":["Hydrolase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"206.5","prostate":"101.8","thyroid gland":"97.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"357.4","Esophageal apical cells":"388.9","Oocytes":"432.9","Prostatic glandular cells":"355.5","Syncytiotrophoblasts":"901.3","Thymic myoid cells":"284.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"901.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"176.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"135709329.5","Oocytes":"138872299.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"4183840.5","kidney":"6734700.2","salivary gland":"1782946.8"},"Antibody":["HPA000663","CAB009435"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB009435":null,"HPA000663":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.17e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.03e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.33e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"}},{"Gene":"ARHGAP11B","Gene synonym":["B'-T","FAM7B1"],"Ensembl":"ENSG00000285077","Gene description":"Rho GTPase activating protein 11B","Uniprot":["Q3KRB8"],"Chromosome":"15","Position":"30624494-30649529","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"4.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enteric transient amplifying cells":"3.6","Extravillous trophoblasts":"1.5","Foveolar cells":"1.1","Gastric chief cells":"1.1","Kupffer cells":"1.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"1.1","Proliferating cells":"3.6","Trophoblast cells":"1.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA064479"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA064479":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ARHGAP15","Gene synonym":["BM046"],"Ensembl":"ENSG00000075884","Gene description":"Rho GTPase activating protein 15","Uniprot":["Q53QZ3"],"Chromosome":"2","Position":"143091362-143768352","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"75.1","lymphoid tissue":"70.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophil progenitors":"5134.5","Neutrophils":"10528.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neutrophils":"10528.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1510.9","leukocyte":"2114.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"69.1","lymphoma":"63.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA032126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"}},{"Gene":"ARHGAP24","Gene synonym":["DKFZP564B1162","FilGAP","FLJ33877"],"Ensembl":"ENSG00000138639","Gene description":"Rho GTPase activating protein 24","Uniprot":["Q8N264"],"Chromosome":"4","Position":"85475150-86002668","Protein class":["Predicted intracellular proteins"],"Biological process":["Angiogenesis","Differentiation"],"Molecular function":["Developmental protein","GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"93.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"1836.7","Fibro-adipogenic progenitors":"1120.1","Microglia":"4378.1","Neutrophil progenitors":"1961.1","Neutrophils":"1639.8","Syncytiotrophoblasts":"1428.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"1836.7","Glial cells":"4378.1","Neutrophils":"1961.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"5568.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"46.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"16.0","memory B-cell":"47.4","naive B-cell":"36.9","plasmacytoid DC":"12.7"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"47.4","dendritic cells":"12.7","monocytes":"16.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Prostate - Smooth muscle cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"3528888.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"8635317.0","Stomach":"6695811.0"},"Antibody":["HPA014288"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":13,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA014288":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.79e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.64e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.25e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"}},{"Gene":"ARHGAP28","Gene synonym":["FLJ10312","KIAA1314"],"Ensembl":"ENSG00000088756","Gene description":"Rho GTPase activating protein 28","Uniprot":["Q9P2N2"],"Chromosome":"18","Position":"6729716-6915716","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"placenta":"24.3","testis":"72.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"622.9","Late primary spermatocytes":"254.5","Late spermatids":"704.2","Mesothelial cells":"233.5","Myonuclei":"134.7","Podocytes":"1005.6","Prostatic glandular cells":"138.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"1005.6","Spermatogenic cell types":"704.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"117.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"14.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"neutrophil":"2.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"granulocytes":"2.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"32.3","testis cancer":"20.8"},"RNA tissue cell type enrichment":["Kidney - Podocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"2190447.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"8094","Protein tissue specific Intensity":{"lymphoid tissue":"809357.3"},"Antibody":["HPA030413","HPA030414","HPA030415"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Nucleoplasm","Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA030413":null,"HPA030414":null,"HPA030415":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.57e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.08e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.16e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.24e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.94e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"}},{"Gene":"ARHGAP35","Gene synonym":["GRF-1","GRLF1","KIAA1722","P190A","p190ARhoGAP","p190RhoGAP"],"Ensembl":"ENSG00000160007","Gene description":"Rho GTPase activating protein 35","Uniprot":["Q9NRY4"],"Chromosome":"19","Position":"46860997-47005077","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","GTPase activation","Repressor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"1189.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1189.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"17732657.9"},"Antibody":["CAB037311","HPA055184","HPA056470"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies","Microtubules","Aggresome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":12,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Microtubules","Aggresome"],"Antibody RRID":{"CAB037311":null,"HPA055184":null,"HPA056470":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.75e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.71e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"}},{"Gene":"ARHGAP40","Gene synonym":["C20orf95","dJ1100H13.4"],"Ensembl":"ENSG00000124143","Gene description":"Rho GTPase activating protein 40","Uniprot":["Q5TG30"],"Chromosome":"20","Position":"38601809-38651035","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"breast":"28.5","epididymis":"33.6","esophagus":"25.1","skin 1":"42.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"38.0","Early spermatids":"20.9","Ependymal cells":"10.9","Epididymal principal cells":"15.7","Esophageal apical cells":"116.2","Late spermatids":"10.7","Papillary tip epithelial cells":"12.6","Prostatic glandular cells":"17.1","Urothelial cells":"16.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"116.2","Luminal cells":"38.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"11.7","medium spiny neuron":"3.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"14.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"11.8"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"576","Protein cell type specific Intensity":{"Skeletal myofibers":"57571.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042636","HPA042840"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm","Centrosome"],"Antibody RRID":{"HPA042636":null,"HPA042840":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"}},{"Gene":"ARHGAP42","Gene synonym":["AD031","FLJ32810","GRAF3","TMEM133"],"Ensembl":"ENSG00000165895","Gene description":"Rho GTPase activating protein 42","Uniprot":["A6NI28"],"Chromosome":"11","Position":"100687288-100993941","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"29.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"384.1","Endometrial luminal cells":"365.4","Foveolar cells":"473.7","Pericytes":"450.1","Respiratory ciliated cells":"393.2","Rod photoreceptor cells":"583.2","Transitional alveolar cells":"447.6","Urothelial cells":"852.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"852.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"1081.0","vascular associated smooth muscle cell":"400.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adrenal gland - Fibroblasts","Spleen - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2025124.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"38468.7","salivary gland":"23711.9"},"Antibody":["HPA039924","HPA060528"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":1,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039924":null,"HPA060528":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.70e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.31e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-3"}},{"Gene":"ARHGAP9","Gene synonym":["10C","MGC1295"],"Ensembl":"ENSG00000123329","Gene description":"Rho GTPase activating protein 9","Uniprot":["Q9BRR9"],"Chromosome":"12","Position":"57472264-57488814","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"113.0","lymphoid tissue":"96.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"70.4","Hofbauer cells":"73.5","Innate lymphoid cells":"78.9","Late primary spermatocytes":"204.1","Late spermatids":"55.3","monocytes":"54.1","Neutrophil progenitors":"142.2","Neutrophils":"429.3","NK-cells":"147.3","pDCs":"107.1","T-cells":"76.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"107.1","Neutrophils":"429.3","NK-cells":"147.3","Spermatogenic cell types":"204.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"33.6","leukocyte":"57.5","lower rhombic lip":"15.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"392.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"392.7"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Leukemia":"36.2","lymphoma":"18.0","Myeloma":"13.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Breast - T-cells","Kidney - T-cells","Lung - NK-cells (Lung)","Pituitary gland - T-cells","Prostate - T-cells","Skin - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"13471199.6","Macrophages":"10243683.3","Neutrophils":"34647402.1","T-cells":"16695789.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"21749620.4"},"Antibody":["HPA078822"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":14,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA078822":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.36e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"}},{"Gene":"ARHGEF2","Gene synonym":["GEF-H1","GEFH1","KIAA0651","Lfc","LFP40","P40"],"Ensembl":"ENSG00000116584","Gene description":"Rho\/Rac guanine nucleotide exchange factor 2","Uniprot":["Q92974"],"Chromosome":"1","Position":"155946851-156007070","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","Immunity","Innate immunity","Mitosis","Neurogenesis"],"Molecular function":["Developmental protein","Guanine-nucleotide releasing factor"],"Disease involvement":["Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"monocytes":"142.6","Neutrophils":"246.3","Oligodendrocytes":"139.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"246.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"175.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Skin - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"90471188.8"},"Antibody":["HPA043437"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":62,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043437":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.66e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"}},{"Gene":"ARHGEF33","Gene synonym":[],"Ensembl":"ENSG00000214694","Gene description":"Rho guanine nucleotide exchange factor 33","Uniprot":["A8MVX0"],"Chromosome":"2","Position":"38889875-38975454","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"17.5","testis":"10.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"28.6","Cardiomyocytes":"37.4","Choroid plexus epithelial cells":"26.6","Differentiating spermatogonia":"30.2","Early primary spermatocytes":"41.4","Early spermatids":"34.4","Ependymal cells":"70.7","Late primary spermatocytes":"51.4","Late spermatids":"32.1","Oocytes":"46.1","Respiratory ciliated cells":"27.0","Undifferentiated spermatogonia":"30.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"70.7","Myocytes":"37.4","Neuronal cells":"28.6","Oocytes":"46.1","Spermatogenic cell types":"51.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"119.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"eosinophil":"4.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"granulocytes":"4.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"3.7"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"32","RNA mouse brain regional specific nTPM":{"cerebellum":"280.4"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"8","RNA pig brain regional specific nTPM":{"cerebellum":"51.8"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034661","HPA041051"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA034661":null,"HPA041051":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ARHGEF39","Gene synonym":["C9orf100","FLJ14642"],"Ensembl":"ENSG00000137135","Gene description":"Rho guanine nucleotide exchange factor 39","Uniprot":["Q8N4T4"],"Chromosome":"9","Position":"35658875-35675866","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"11.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"73.3","Cardiomyocytes":"125.2","Early spermatids":"133.2","Epicardial cells":"54.6","Extravillous trophoblasts":"21.8","Late primary spermatocytes":"23.5","Late spermatids":"50.8","Monocyte progenitors":"21.3","Vascular smooth muscle cells":"22.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adipocytes":"73.3","Barrier epithelial cells":"54.6","Myocytes":"125.2","Spermatogenic cell types":"133.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"4.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"basal ganglia":"2.7"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA061299"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA061299":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.17e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"}},{"Gene":"ARID2","Gene synonym":["BAF200","DKFZp686G052","FLJ30619","KIAA1557","SMARCF3"],"Ensembl":"ENSG00000189079","Gene description":"AT-rich interaction domain 2","Uniprot":["Q68CP9"],"Chromosome":"12","Position":"45729706-45908040","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","DNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"699.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"5932423.0","Neutrophils":"5569844.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"269007.4","lymphoid tissue":"975612.0","salivary gland":"911727.6"},"Antibody":["HPA063044","HPA078115"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA063044":null,"HPA078115":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"ARID3A","Gene synonym":["BRIGHT","DRIL1"],"Ensembl":"ENSG00000116017","Gene description":"AT-rich interaction domain 3A","Uniprot":["Q99856"],"Chromosome":"19","Position":"925781-975939","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"22.0","testis":"16.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"291.4","Extravillous trophoblasts":"797.6","Hofbauer cells":"240.3","Migrating cytotrophoblasts":"352.7","Neutrophil progenitors":"180.2","Neutrophils":"326.1","pDCs":"246.7","Syncytiotrophoblasts":"783.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"246.7","Mononuclear phagocytes":"240.3","Neutrophils":"326.1","Trophoblast cells":"797.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"133.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"6.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Somatotropes","Spleen - Mitotic cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"18854663.6","Neutrophils":"7966932.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"3268012.9"},"Antibody":["HPA004793","HPA076330"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":22,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA004793":null,"HPA076330":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-6"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.79e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.53e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"}},{"Gene":"ARID3C","Gene synonym":[],"Ensembl":"ENSG00000205143","Gene description":"AT-rich interaction domain 3C","Uniprot":["A6NKF2"],"Chromosome":"9","Position":"34621049-34629066","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"27","RNA tissue specific nTPM":{"liver":"10.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"1.3","Hepatocytes":"4.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"4.3","Proliferating cells":"1.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"2.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Skin - Inner root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ARID4B","Gene synonym":["BCAA","BRCAA1","RBP1L1","SAP180"],"Ensembl":"ENSG00000054267","Gene description":"AT-rich interaction domain 4B","Uniprot":["Q4LE39"],"Chromosome":"1","Position":"235131634-235328219","Protein class":["Metabolic proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"2078.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2078.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":47,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA027205":null,"HPA027333":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"ARIH1","Gene synonym":["ARI","HARI","HHARI","UBCH7BP"],"Ensembl":"ENSG00000166233","Gene description":"Ariadne RBR E3 ubiquitin protein ligase 1","Uniprot":["Q9Y4X5"],"Chromosome":"15","Position":"72474330-72602987","Protein class":["Disease related genes","Enzymes","Essential proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"44.9","testis":"39.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"2015.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2015.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":54,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA003295":null,"HPA073245":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.26e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.87e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"}},{"Gene":"ARL13A","Gene synonym":["ARL13"],"Ensembl":"ENSG00000174225","Gene description":"ADP ribosylation factor like GTPase 13A","Uniprot":["Q5H913"],"Chromosome":"X","Position":"100969708-100990831","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"4.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"72.6","Late primary spermatocytes":"37.5","Late spermatids":"88.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"88.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037377","HPA037378"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Actin filaments","Cytosol","Acrosome","Connecting piece","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 36: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Plasma membrane","Actin filaments","Connecting piece","Mid piece"],"Subcellular additional location":["Cytosol","Acrosome","Principal piece"],"Antibody RRID":{"HPA037377":null,"HPA037378":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":27,"Subcellular main location":["Vesicles","Focal adhesion sites","Cytosol"],"Subcellular additional location":["Nucleoplasm","Nucleoli","Plasma membrane"],"Antibody RRID":{"HPA039634":null,"HPA048127":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.30e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.58e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.75e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"}},{"Gene":"ARL14EPL","Gene synonym":[],"Ensembl":"ENSG00000268223","Gene description":"ADP ribosylation factor like GTPase 14 effector protein like","Uniprot":["P0DKL9"],"Chromosome":"5","Position":"116032324-116060118","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"3.0","Cardiomyocytes":"4.4","Early spermatids":"5.5","Endometrial ciliated cells":"3.2","Gastric chief cells":"5.5","Mucous neck cells":"3.5","Papillary tip epithelial cells":"2.7","Parietal cells":"7.1","Renal collecting duct principal cells":"3.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"7.1","Myocytes":"4.4","Spermatogenic cell types":"5.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"7.0","lymphoma":"6.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ARL2","Gene synonym":["ARFL2"],"Ensembl":"ENSG00000213465","Gene description":"ADP ribosylation factor like GTPase 2","Uniprot":["P36404"],"Chromosome":"11","Position":"65014160-65022184","Protein class":["Disease related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"77.4","Late spermatids":"290.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"290.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"9773247.8"},"Antibody":["HPA044610"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Mitochondria","Basal body","Equatorial segment","Flagellar centriole","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.83e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"}},{"Gene":"ARL2BP","Gene synonym":["BART","BART1","RP66"],"Ensembl":"ENSG00000102931","Gene description":"ADP ribosylation factor like GTPase 2 binding protein","Uniprot":["Q9Y2Y0"],"Chromosome":"16","Position":"57245259-57253635","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"318.4","Esophageal apical cells":"216.1","Late spermatids":"811.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"216.1","Spermatogenic cell types":"811.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":18,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Centrosome","Basal body"],"Antibody RRID":{"HPA043066":null,"HPA048440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"}},{"Gene":"ARL3","Gene synonym":["ARFL3"],"Ensembl":"ENSG00000138175","Gene description":"ADP ribosylation factor like GTPase 3","Uniprot":["P36405"],"Chromosome":"10","Position":"102673731-102714397","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"89.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct ciliated cells":"280.4","Fallopian tube ciliated cells":"402.8","Respiratory ciliated cells":"306.0","Rod photoreceptor cells":"382.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"402.8","Neuronal cells":"382.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Fibroblasts_1","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036292","HPA063596"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Primary cilium","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"14000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":42,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA036292":null,"HPA063596":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.09e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"}},{"Gene":"ARL4A","Gene synonym":["ARL4"],"Ensembl":"ENSG00000122644","Gene description":"ADP ribosylation factor like GTPase 4A","Uniprot":["P40617"],"Chromosome":"7","Position":"12686856-12690958","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"181.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"6441.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6441.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"86.7","endothelial cell":"148.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"13303.5"},"Antibody":["HPA064513"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":9,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA064513":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"}},{"Gene":"ARL4D","Gene synonym":["ARF4L"],"Ensembl":"ENSG00000175906","Gene description":"ADP ribosylation factor like GTPase 4D","Uniprot":["P49703"],"Chromosome":"17","Position":"43398993-43401137","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"154.6","Decidual stromal cells":"153.8","Early spermatids":"263.4","Esophageal apical cells":"321.5","Esophageal basal cells":"198.1","Esophageal suprabasal cells":"411.6","Ocular epithelial cells":"483.2","Rod photoreceptor cells":"326.4","Suprabasal keratinocytes":"192.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"321.5","Barrier epithelial cells":"483.2","Neuronal cells":"326.4","Spermatogenic cell types":"263.4","Suprabasal cells":"411.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"32.4","naive B-cell":"36.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"36.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":21,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA060379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.04e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"}},{"Gene":"ARL6","Gene synonym":["BBS3","RP55"],"Ensembl":"ENSG00000113966","Gene description":"ADP ribosylation factor like GTPase 6","Uniprot":["Q9H0F7"],"Chromosome":"3","Position":"97764521-97801229","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Protein transport","Sensory transduction","Transport","Vision"],"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Intellectual disability","Obesity","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"35.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"134.6","Ependymal cells":"104.4","Respiratory ciliated cells":"136.1","Rod photoreceptor cells":"230.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"136.1","Neuronal cells":"230.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"17.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3338453.2","Microglia and Neuropil":"2933285.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1002275.8","fallopian tube":"1593331.0"},"Antibody":["HPA019361"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Microtubules","Primary cilium","Primary cilium tip","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":5,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Nucleoplasm","Primary cilium tip","Cytosol"],"Antibody RRID":{"HPA019361":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"}},{"Gene":"ARL9","Gene synonym":[],"Ensembl":"ENSG00000196503","Gene description":"ADP ribosylation factor like GTPase 9","Uniprot":["Q6T311"],"Chromosome":"4","Position":"56505209-56524959","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"11.0","testis":"8.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"113.2","Late primary spermatocytes":"97.7","Late spermatids":"442.5","Pituicytes\/FSCs":"34.1","Retinal pigment epithelial cells":"59.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"442.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"6.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebellum":"1.3"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA058135","HPA072942"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Centriolar satellite","Cytosol"],"Antibody RRID":{"HPA058135":null,"HPA072942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"}},{"Gene":"ARMC2","Gene synonym":["bA787I22.1","DKFZp434P0714"],"Ensembl":"ENSG00000118690","Gene description":"Armadillo repeat containing 2","Uniprot":["Q8NEN0"],"Chromosome":"6","Position":"108848416-108974476","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"31.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"640.4","Ependymal cells":"574.3","Fallopian tube ciliated cells":"256.8","Late spermatids":"223.0","Respiratory ciliated cells":"515.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"640.4","Spermatogenic cell types":"223.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"600.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3022","Protein cell type specific Intensity":{"Fallopian tube cells":"302245.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA025809","HPA053696"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.10e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037823":null,"HPA037824":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"}},{"Gene":"ARMC7","Gene synonym":["FLJ22160"],"Ensembl":"ENSG00000125449","Gene description":"Armadillo repeat containing 7","Uniprot":["Q9H6L4"],"Chromosome":"17","Position":"75109952-75130272","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oocytes":"50.7","Paneth cells":"65.7","Renal collecting duct intercalated cells":"60.5","Renal collecting duct principal cells":"56.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Secretory gland support":"65.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":63,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA024229":null,"HPA053076":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":["Mid piece","Annulus"],"Antibody RRID":{"HPA019041":null,"HPA026671":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA034769":null,"HPA034770":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"}},{"Gene":"ARMH2","Gene synonym":["C6orf229"],"Ensembl":"ENSG00000260286","Gene description":"Armadillo like helical domain containing 2","Uniprot":["H3BNL8"],"Chromosome":"6","Position":"24797335-24798917","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"12.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"19.6","Late primary spermatocytes":"49.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"49.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"2.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":["End piece"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA067225":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ARPC2","Gene synonym":["ARC34","p34-Arc"],"Ensembl":"ENSG00000163466","Gene description":"Actin related protein 2\/3 complex subunit 2","Uniprot":["O15144"],"Chromosome":"2","Position":"218217141-218254356","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"3043.0","Esophageal suprabasal cells":"2017.3","Extravillous trophoblasts":"2092.6","Neutrophils":"1912.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"3043.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7600000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":81,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB001994":null,"HPA008352":null,"HPA052703":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.24e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"}},{"Gene":"ARPC5L","Gene synonym":["ARC16-2","MGC3038"],"Ensembl":"ENSG00000136950","Gene description":"Actin related protein 2\/3 complex subunit 5 like","Uniprot":["Q9BPX5"],"Chromosome":"9","Position":"124862130-124877733","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"580.7","Esophageal apical cells":"792.4","Esophageal suprabasal cells":"457.8","Late primary spermatocytes":"496.5","Late spermatids":"1392.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"792.4","Spermatogenic cell types":"1392.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":47,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA022013":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.47e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"}},{"Gene":"ARRDC5","Gene synonym":[],"Ensembl":"ENSG00000205784","Gene description":"Arrestin domain containing 5","Uniprot":["A6NEK1"],"Chromosome":"19","Position":"4890437-4902896","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"16.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"291.3","Late primary spermatocytes":"167.2","Late spermatids":"64.6","Microglia":"23.4","Neutrophil progenitors":"46.1","pDCs":"27.7","Thymocytes":"30.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"291.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"40","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"28.3","leukocyte":"23.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ARSA","Gene synonym":["ASA"],"Ensembl":"ENSG00000100299","Gene description":"Arylsulfatase A","Uniprot":["P15289"],"Chromosome":"22","Position":"50622754-50628173","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Ichthyosis","Leukodystrophy","Metachromatic leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"85.3","Enterocytes":"90.4","Fallopian tube ciliated cells":"103.1","Late primary spermatocytes":"84.5","Late spermatids":"215.5","Plasma cells":"85.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"215.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"6594994.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005554","CAB025183"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus","Cytosol","Mid piece"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2400000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":37,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol","Mid piece"],"Antibody RRID":{"CAB025183":null,"HPA005554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"}},{"Gene":"ART5","Gene synonym":["ARTC5"],"Ensembl":"ENSG00000167311","Gene description":"ADP-ribosyltransferase 5","Uniprot":["Q96L15"],"Chromosome":"11","Position":"3638512-3642316","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"11.1","skeletal muscle":"12.6","testis":"28.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"118.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"118.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"2.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"9.7","Testicular Germ Cell Tumor (TCGA)":"10.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"testis cancer":"12.7"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041637","HPA044099"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041637":null,"HPA044099":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"}},{"Gene":"ARV1","Gene synonym":[],"Ensembl":"ENSG00000173409","Gene description":"ARV1 homolog, fatty acid homeostasis modulator","Uniprot":["Q9H2C2"],"Chromosome":"1","Position":"230978981-231000733","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Cholesterol metabolism","Lipid metabolism","Lipid transport","Steroid metabolism","Sterol metabolism","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"211.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"211.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035709"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":13,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035709":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.07e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"}},{"Gene":"ASAP2","Gene synonym":["CENTB3","DDEF2","KIAA0400","PAP","SHAG1"],"Ensembl":"ENSG00000151693","Gene description":"ArfGAP with SH3 domain, ankyrin repeat and PH domain 2","Uniprot":["O43150"],"Chromosome":"2","Position":"9206765-9405683","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"43.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"463.9","Lactotrophs":"534.7","Megakaryocytes":"352.4","Platelets":"355.5","Renal connecting tubule cells":"617.6","Somatotrophs":"526.7","Thyrotrophs":"358.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"617.6","Pituitary endocrine cells":"534.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"basophil":"2.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"2.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":11,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB018615":null,"HPA068383":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.17e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"}},{"Gene":"ASB15","Gene synonym":["FLJ43370"],"Ensembl":"ENSG00000146809","Gene description":"Ankyrin repeat and SOCS box containing 15","Uniprot":["Q8WXK1"],"Chromosome":"7","Position":"123567010-123639481","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"25.5","skeletal muscle":"111.8","tongue":"78.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cardiomyocytes":"412.8","Myonuclei":"440.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"440.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"2.3","upper rhombic lip":"3.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"392816.6","ovary":"744404.4"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ASB17","Gene synonym":[],"Ensembl":"ENSG00000154007","Gene description":"Ankyrin repeat and SOCS box containing 17","Uniprot":["Q8WXJ9"],"Chromosome":"1","Position":"75918873-75932404","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"214","RNA tissue specific nTPM":{"testis":"46.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"26","RNA single cell type specific nCPM":{"Early spermatids":"1284.5","Late primary spermatocytes":"345.0","Late spermatids":"472.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"49","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1284.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ASB4","Gene synonym":["ASB-4"],"Ensembl":"ENSG00000005981","Gene description":"Ankyrin repeat and SOCS box containing 4","Uniprot":["Q9Y574"],"Chromosome":"7","Position":"95478444-95540233","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"44.5","skeletal muscle":"32.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"190.5","Adrenal medulla cells":"42.5","Early spermatids":"37.3","Lactotrophs":"122.1","Late primary spermatocytes":"26.2","Late spermatids":"59.0","Myonuclei":"35.0","Somatotrophs":"50.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"190.5","Pituitary endocrine cells":"122.1","Spermatogenic cell types":"59.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"7.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"3.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"7.9","skin cancer":"9.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Pituitary gland - Lactotropes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"basal ganglia":"9.5","hypothalamus":"31.7"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"11","RNA pig brain regional specific nTPM":{"midbrain":"6.6"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"417","Protein cell type specific Intensity":{"Skeletal myofibers":"41694.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA055240"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 18: Adrenal cortex cells - Steroidogensis","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055240":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ASCC2","Gene synonym":["ASC1p100","DKFZp586O0223","FLJ21588"],"Ensembl":"ENSG00000100325","Gene description":"Activating signal cointegrator 1 complex subunit 2","Uniprot":["Q9H1I8"],"Chromosome":"22","Position":"29788609-29838304","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"659.7","Late spermatids":"200.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"659.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001439","HPA052879"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Focal adhesion sites","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":26,"Subcellular main location":["Focal adhesion sites","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA001439":null,"HPA052879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"}},{"Gene":"ASGR1","Gene synonym":["CLEC4H1"],"Ensembl":"ENSG00000141505","Gene description":"Asialoglycoprotein receptor 1","Uniprot":["P07306"],"Chromosome":"17","Position":"7173431-7179564","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Endocytosis","Host-virus interaction"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"45","RNA tissue specific nTPM":{"liver":"1142.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Hepatocytes":"1286.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Hepatocytes":"1286.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"37.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"59","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"494.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"115.4","intermediate monocyte":"55.6","myeloid DC":"41.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"dendritic cells":"41.2","monocytes":"115.4"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"liver cancer":"80.4"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"9","RNA mouse brain regional specific nTPM":{"cerebellum":"44.1"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"663867","Protein cell type specific Intensity":{"Hepatocytes":"66386714.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"83233213.9"},"Antibody":["HPA011954","HPA012852"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cell Junctions"],"Secretome location":"Secreted to blood","Secretome function":"Receptor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":1710000,"Blood concentration - Conc. blood MS [pg\/L]":"360000","Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":31,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA011954":null,"HPA012852":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.17e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"}},{"Gene":"ASIC2","Gene synonym":["ACCN","ACCN1","ASIC2a","BNaC1","BNC1","hBNaC1","MDEG"],"Ensembl":"ENSG00000108684","Gene description":"Acid sensing ion channel subunit 2","Uniprot":["Q16515"],"Chromosome":"17","Position":"33013087-34174964","Protein class":["Plasma proteins","Predicted membrane proteins"],"Biological process":["Ion transport","Sodium transport","Transport"],"Molecular function":["Ion channel","Sodium channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"12.7","cervix":"5.5","endometrium 1":"3.2","retina":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"86.2","Brain inhibitory neurons":"116.7","Early spermatids":"115.1","Late spermatids":"192.3","Oligodendrocyte progenitor cells":"290.2","Other brain neurons":"136.5","Respiratory ionocytes":"312.4","Retinal amacrine cells":"208.2","Retinal bipolar cells":"282.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"290.2","Ionocytes":"312.4","Neuronal cells":"282.9","Spermatogenic cell types":"192.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Bone cancer":"4.9","Neuroblastoma":"1.7"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052112":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"}},{"Gene":"ASNS","Gene synonym":[],"Ensembl":"ENSG00000070669","Gene description":"Asparagine synthetase (glutamine-hydrolyzing)","Uniprot":["P08243"],"Chromosome":"7","Position":"97851677-97872542","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Amino-acid biosynthesis","Asparagine biosynthesis"],"Molecular function":["Ligase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"114.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"18.6","Bergmann glia":"16.0","Brain excitatory neurons":"59.7","Brain inhibitory neurons":"50.2","Choroid plexus epithelial cells":"13.1","Ependymal cells":"11.4","Loop of henle epithelial cells":"9.8","Microglia":"10.0","Oligodendrocyte progenitor cells":"31.0","Oligodendrocytes":"21.4","Other brain neurons":"46.1","Podocytes":"17.3","Renal connecting tubule cells":"11.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"13.1","Ductal cells":"11.9","Glial cells":"31.0","Neuronal cells":"59.7","Renal nephron cells":"17.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"9.0","T-cells":"14.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"86804804.0","Pancreatic islets":"26226562.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"41726294.4","Stomach":"60836298.6"},"Antibody":["HPA004924","HPA029318","HPA064737"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":14,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA004924":null,"HPA029318":null,"HPA064737":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.03e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.15e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.91e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"ASRGL1","Gene synonym":["ALP","ALP1","FLJ22316"],"Ensembl":"ENSG00000162174","Gene description":"Asparaginase and isoaspartyl peptidase 1","Uniprot":["Q7L266"],"Chromosome":"11","Position":"62337448-62393412","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"123.8","cervix":"114.4","testis":"93.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"337.0","Endometrial ciliated cells":"384.2","Endometrial glandular cells":"452.0","Endometrial luminal cells":"518.2","Epididymal efferent duct absorptive cells":"668.0","Fallopian secretory cells":"324.9","Fallopian tube ciliated cells":"478.2","Late primary spermatocytes":"1172.3","Late spermatids":"893.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"478.2","Ductal cells":"668.0","Glandular cells":"452.0","Luminal cells":"518.2","Spermatogenic cell types":"1172.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"232.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"279.2","eosinophil":"270.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"279.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"42899731.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"65704211.3","fallopian tube":"137765147.8","kidney":"126880231.2"},"Antibody":["HPA029725","HPA055572","CAB070192"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Microtubules","Cytokinetic bridge"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Nucleoplasm","Cytokinetic bridge"],"Antibody RRID":{"CAB070192":null,"HPA029725":null,"HPA055572":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.71e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"}},{"Gene":"ASTE1","Gene synonym":["HT001"],"Ensembl":"ENSG00000034533","Gene description":"Asteroid homolog 1","Uniprot":["Q2TB18"],"Chromosome":"3","Position":"131013875-131027649","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"53.5","Epicardial cells":"66.0","Late primary spermatocytes":"42.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"66.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"4967721.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"5222","Protein tissue specific Intensity":{"lymphoid tissue":"636030.4","ovary":"408427.9"},"Antibody":["HPA037010","HPA037011"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":1,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA037010":null,"HPA037011":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"}},{"Gene":"ASTN1","Gene synonym":["ASTN"],"Ensembl":"ENSG00000152092","Gene description":"Astrotactin 1","Uniprot":["O14525"],"Chromosome":"1","Position":"176857302-177164973","Protein class":["Plasma proteins","Predicted membrane proteins","Transporters"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"14.1","brain":"37.4","retina":"13.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"168.2","Astrocytes":"301.6","Brain excitatory neurons":"280.5","Brain inhibitory neurons":"301.3","Corticotrophs":"479.1","Gonadotrophs":"272.5","Lactotrophs":"246.1","Oligodendrocyte progenitor cells":"456.6","Other brain neurons":"207.0","Pituicytes\/FSCs":"182.6","Pituitary stem cells":"298.4","Retinal amacrine cells":"343.9","Retinal horizontal cells":"204.3","Rod photoreceptor cells":"145.1","Thyrotrophs":"185.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"168.2","Glial cells":"456.6","Neuronal cells":"343.9","Pituitary endocrine cells":"479.1","Stem cells":"298.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"16","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"32.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"3.4","Neuroblastoma":"4.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA074112":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ASXL1","Gene synonym":["KIAA0978"],"Ensembl":"ENSG00000171456","Gene description":"ASXL transcriptional regulator 1","Uniprot":["Q8IXJ9"],"Chromosome":"20","Position":"32358330-32439319","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Chromatin regulator","Repressor"],"Disease involvement":["Cancer-related genes","Craniosynostosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"44","Protein cell type specific Intensity":{"Granulosa cells":"4409.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA064156"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":55,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA064156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.45e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"}},{"Gene":"ASXL2","Gene synonym":["ASXH2","FLJ10898","KIAA1685"],"Ensembl":"ENSG00000143970","Gene description":"ASXL transcriptional regulator 2","Uniprot":["Q76L83"],"Chromosome":"2","Position":"25733753-25878487","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Repressor"],"Disease involvement":["Cancer-related genes","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"656645.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"23234.3"},"Antibody":["HPA034646","HPA058040"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034646":null,"HPA058040":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.25e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.95e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"}},{"Gene":"ASXL3","Gene synonym":["KIAA1713"],"Ensembl":"ENSG00000141431","Gene description":"ASXL transcriptional regulator 3","Uniprot":["Q9C0F0"],"Chromosome":"18","Position":"33578219-33751195","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"101.0","Choroid plexus epithelial cells":"136.3","Corticotrophs":"206.8","Distal convoluted tubule cells":"127.4","Early spermatids":"136.6","Oligodendrocyte progenitor cells":"101.2","Other brain neurons":"109.2","Pituitary stem cells":"336.5","Renal collecting duct intercalated cells":"101.9","Renal connecting tubule cells":"147.9","Retinal amacrine cells":"195.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"195.5","Pituitary endocrine cells":"206.8","Stem cells":"336.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"1.5","Neuroblastoma":"1.1","Sarcoma":"1.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039539","HPA040034"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039539":null,"HPA040034":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ATAD1","Gene synonym":["FLJ14600","Msp1"],"Ensembl":"ENSG00000138138","Gene description":"ATPase family AAA domain containing 1","Uniprot":["Q8NBU5"],"Chromosome":"10","Position":"87751512-87841361","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Translocase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1074.7","Late spermatids":"2786.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2786.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6400","Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":5,"Subcellular main location":["Nucleoli rim"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA037569":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.70e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"}},{"Gene":"ATAD2B","Gene synonym":["KIAA1240"],"Ensembl":"ENSG00000119778","Gene description":"ATPase family AAA domain containing 2B","Uniprot":["Q9ULI0"],"Chromosome":"2","Position":"23748664-23927123","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 49: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":92,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB003769":null,"HPA022134":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.37e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":17,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA016578":null,"HPA023505":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"}},{"Gene":"ATG10","Gene synonym":["APG10L","DKFZP586I0418","FLJ13954"],"Ensembl":"ENSG00000152348","Gene description":"Autophagy related 10","Uniprot":["Q9H0Y0"],"Chromosome":"5","Position":"81972023-82276857","Protein class":["Predicted intracellular proteins"],"Biological process":["Autophagy","Protein transport","Transport","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Thymocytes":"431.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":15,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA044163":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":172,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA039350":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":6,"Subcellular main location":["Endoplasmic reticulum","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA001427":null,"HPA005734":null,"HPA019665":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.91e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"}},{"Gene":"ATG3","Gene synonym":["APG3L","DKFZp564M1178","FLJ22125","MGC15201","PC3-96"],"Ensembl":"ENSG00000144848","Gene description":"Autophagy related 3","Uniprot":["Q9NT62"],"Chromosome":"3","Position":"112532510-112562046","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Autophagy","Protein transport","Transport","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"767.9","Late primary spermatocytes":"649.2","Neutrophils":"385.0","Oocytes":"327.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"385.0","Spermatogenic cell types":"767.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"90000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":35,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB037260":null,"HPA040471":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.90e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"}},{"Gene":"ATG4D","Gene synonym":["APG4-D","APG4D","AUTL4"],"Ensembl":"ENSG00000130734","Gene description":"Autophagy related 4D cysteine peptidase","Uniprot":["Q86TL0"],"Chromosome":"19","Position":"10543895-10553418","Protein class":["Enzymes","Predicted intracellular proteins","Transporters"],"Biological process":["Apoptosis","Autophagy","Protein transport","Transport","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"103.2","Enterocytes":"112.9","Esophageal apical cells":"90.4","Late primary spermatocytes":"211.4","Megakaryocytes":"136.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"136.0","Spermatogenic cell types":"211.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA067683"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":null,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA067683":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"}},{"Gene":"ATG7","Gene synonym":["APG7L","DKFZp434N0735","GSA7"],"Ensembl":"ENSG00000197548","Gene description":"Autophagy related 7","Uniprot":["O95352"],"Chromosome":"3","Position":"11272309-11557665","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Autophagy","Biological rhythms","Protein transport","Transport","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"1324.4","Neutrophils":"1938.6","Oocytes":"1418.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1938.6","Oocytes":"1418.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA007639","CAB018771"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol","Connecting piece","Flagellar centriole","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"42000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":36,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Plasma membrane","Connecting piece","Flagellar centriole","Mid piece"],"Antibody RRID":{"CAB018771":null,"HPA007639":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.02e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"}},{"Gene":"ATG9A","Gene synonym":["APG9L1","FLJ22169"],"Ensembl":"ENSG00000198925","Gene description":"Autophagy related 9A","Uniprot":["Q7Z3C6"],"Chromosome":"2","Position":"219219380-219229717","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Autophagy","Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"136.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"16.3","Bergmann glia":"12.6","Brain excitatory neurons":"17.8","Brain inhibitory neurons":"18.0","Oligodendrocyte progenitor cells":"17.6","Oligodendrocytes":"18.4","Other brain neurons":"16.2","Tuft cells":"46.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"18.4","Neuronal cells":"18.0","Secretory gland support":"46.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"3069581.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"3363428.4"},"Antibody":["HPA059551"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":52,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA059551":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"}},{"Gene":"ATG9B","Gene synonym":["APG9L2","FLJ14885","NOS3AS","SONE"],"Ensembl":"ENSG00000181652","Gene description":"Autophagy related 9B","Uniprot":["Q674R7"],"Chromosome":"7","Position":"151012209-151024499","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Autophagy","Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"9.9","pituitary gland":"5.9","testis":"6.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Esophageal apical cells":"312.4","Syncytiotrophoblasts":"393.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"312.4","Trophoblast cells":"393.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"32.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"6.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Liver - Vascular endothelial cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"ATL1","Gene synonym":["AD-FSP","FSP1","SPG3","SPG3A"],"Ensembl":"ENSG00000198513","Gene description":"Atlastin GTPase 1","Uniprot":["Q8WXF7"],"Chromosome":"14","Position":"50532509-50634017","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"56.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"159.9","Brain inhibitory neurons":"152.0","Breast lactating cells":"152.3","Oligodendrocyte progenitor cells":"133.2","Oligodendrocytes":"196.1","Other brain neurons":"171.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"196.1","Neuronal cells":"171.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"12.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"12.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"12.6"},"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"85647409.4","Microglia and Neuropil":"87422047.6","Neurons":"87864723.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"108890776.8"},"Antibody":["HPA027550"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"19000","Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":28,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA027550":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.15e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.96e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"}},{"Gene":"ATMIN","Gene synonym":["ASCIZ","KIAA0431","ZNF822"],"Ensembl":"ENSG00000166454","Gene description":"ATM interactor","Uniprot":["O43313"],"Chromosome":"16","Position":"81035842-81047350","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","Transcription","Transcription regulation"],"Molecular function":["Activator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"225.0","Late spermatids":"438.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"438.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054967","HPA066900"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":11,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA054967":null,"HPA066900":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"}},{"Gene":"ATP1A3","Gene synonym":["DYT12"],"Ensembl":"ENSG00000105409","Gene description":"ATPase Na+\/K+ transporting subunit alpha 3","Uniprot":["P13637"],"Chromosome":"19","Position":"41966582-41997497","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Potassium transport","Sodium transport","Sodium\/potassium transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":["Deafness","Disease variant","Dystonia","Epilepsy","Intellectual disability","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"brain":"279.0","heart muscle":"147.7","retina":"271.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Brain excitatory neurons":"115.6","Brain inhibitory neurons":"169.2","Other brain neurons":"180.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Neuronal cells":"180.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"460.3"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"43.7","Kidney Chromophobe (TCGA)":"24.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"70.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"580000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":120,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB033630":null,"HPA045367":null,"HPA056446":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.73e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.72e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.62e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ATP1A4","Gene synonym":["ATP1AL2"],"Ensembl":"ENSG00000132681","Gene description":"ATPase Na+\/K+ transporting subunit alpha 4","Uniprot":["Q13733"],"Chromosome":"1","Position":"160151586-160186980","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Ion transport","Potassium transport","Sodium transport","Sodium\/potassium transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"5.9","testis":"15.4","urinary bladder":"4.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"36.5","Early spermatids":"106.3","Extravillous trophoblasts":"21.9","Late primary spermatocytes":"56.7","Mast cells":"20.2","Migrating cytotrophoblasts":"30.8","Myonuclei":"31.0","Syncytiotrophoblasts":"63.9","Urothelial cells":"57.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"57.5","Myocytes":"31.0","Spermatogenic cell types":"106.3","Trophoblast cells":"63.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"6.2","Bergmann glia":"16.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"2.4","Breast Invasive Carcinoma (TCGA)":"1.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bladder cancer":"2.5","lymphoma":"1.5","testis cancer":"1.6"},"RNA tissue cell type enrichment":["Pituitary gland - Undifferentiated cells (Pituitary gland)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"65","Protein cell type specific Intensity":{"Cardiomyocytes":"6531.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":null,"Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ATP23","Gene synonym":["KUB3","XRCC6BP1"],"Ensembl":"ENSG00000166896","Gene description":"ATP23 metallopeptidase and ATP synthase assembly factor homolog","Uniprot":["Q9Y6H3"],"Chromosome":"12","Position":"57906039-57959148","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"6.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"58.8","Late primary spermatocytes":"82.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"82.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"neutrophil":"1.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"1.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":24,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":["Cell Junctions","Cytosol"],"Antibody RRID":{"HPA035804":null,"HPA043204":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ATP2B2","Gene synonym":["PMCA2"],"Ensembl":"ENSG00000157087","Gene description":"ATPase plasma membrane Ca2+ transporting 2","Uniprot":["Q01814"],"Chromosome":"3","Position":"10324023-10708007","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calmodulin-binding","Translocase"],"Disease involvement":["Deafness","Disease variant","FDA approved drug targets","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"88.0","choroid plexus":"61.0","salivary gland":"31.3","skeletal muscle":"35.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1350.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"1350.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"13.5","Liver Hepatocellular Carcinoma (TCGA)":"15.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"2.7","Neuroblastoma":"3.3"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB005606":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.09e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"}},{"Gene":"ATP5IF1","Gene synonym":["ATPI","ATPIF1","ATPIP","IP","MGC1167","MGC8898"],"Ensembl":"ENSG00000130770","Gene description":"ATP synthase inhibitory factor subunit 1","Uniprot":["Q9UII2"],"Chromosome":"1","Position":"28236109-28246906","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1499.2","Endometrial ciliated cells":"759.2","Granulosa cells":"715.3","Late primary spermatocytes":"2589.3","Parietal cells":"705.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2589.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"31294660.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1210926921.3"},"Antibody":["HPA027999"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"74000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":54,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA027999":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.78e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"}},{"Gene":"ATP5MF","Gene synonym":["ATP5J2","ATP5JL"],"Ensembl":"ENSG00000241468","Gene description":"ATP synthase membrane subunit f","Uniprot":["P56134"],"Chromosome":"7","Position":"99448475-99466186","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["ATP synthesis","Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1019.7","Esophageal suprabasal cells":"844.4","Gastric progenitor cells":"1499.6","Hofbauer cells":"813.6","Megakaryocytes":"846.9","Parietal cells":"1083.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"1499.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"354271734.2","Distal tubules":"300391149.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"66875041.0"},"Antibody":["HPA067267","HPA070412"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"47000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA067267":null,"HPA070412":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.13e-7"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"ATP5MG","Gene synonym":["ATP5JG","ATP5L"],"Ensembl":"ENSG00000167283","Gene description":"ATP synthase membrane subunit g","Uniprot":["O75964"],"Chromosome":"11","Position":"118401346-118433278","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["ATP synthesis","Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Parietal cells":"2796.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"2796.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA044629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.83e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"}},{"Gene":"ATP5PB","Gene synonym":["ATP5F1"],"Ensembl":"ENSG00000116459","Gene description":"ATP synthase peripheral stalk-membrane subunit b","Uniprot":["P24539"],"Chromosome":"1","Position":"111448864-111462773","Protein class":["Essential proteins","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"127.5","tongue":"122.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"586.0","Late primary spermatocytes":"583.9","Parietal cells":"899.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"899.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"91000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":113,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA046067":null,"HPA057347":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.65e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.29e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"ATP5PF","Gene synonym":["ATP5","ATP5A","ATP5J","ATPM","CF6"],"Ensembl":"ENSG00000154723","Gene description":"ATP synthase peripheral stalk subunit F6","Uniprot":["P18859"],"Chromosome":"21","Position":"25716503-25735673","Protein class":["Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"tongue":"1487.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"1306.6","Hepatocytes":"1869.1","Parietal cells":"2635.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"2635.9","Hepatocytes":"1869.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"125063410.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1322109925.0"},"Antibody":["HPA031069"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Flagellar centriole","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"240000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":81,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Flagellar centriole","End piece"],"Antibody RRID":{"HPA031069":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"ATP5PO","Gene synonym":["ATP5O","ATPO","OSCP"],"Ensembl":"ENSG00000241837","Gene description":"ATP synthase peripheral stalk subunit OSCP","Uniprot":["P48047"],"Chromosome":"21","Position":"33903453-33915814","Protein class":["Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["ATP synthesis","Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"tongue":"1494.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"770.7","Esophageal basal cells":"774.3","Esophageal suprabasal cells":"989.4","Late primary spermatocytes":"769.1","Parietal cells":"1591.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"1591.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"936814381.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"633474859.1"},"Antibody":["CAB016209","HPA041394"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":72,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB016209":null,"HPA041394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.51e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"}},{"Gene":"ATP6V0D1","Gene synonym":["ATP6D","ATP6DV","P39","VATX","Vma6","VPATPD"],"Ensembl":"ENSG00000159720","Gene description":"ATPase H+ transporting V0 subunit d1","Uniprot":["P61421"],"Chromosome":"16","Position":"67438014-67481181","Protein class":["Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation","Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hofbauer cells":"364.3","Neutrophils":"666.7","Syncytiotrophoblasts":"418.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"666.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"211453962.5","Microglia and Neuropil":"282159394.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"227544143.7"},"Antibody":["HPA016938"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":72,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016938":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.60e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.63e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"}},{"Gene":"ATP6V1E2","Gene synonym":["ATP6E1","ATP6EL2","ATP6V1EL2","MGC9341","VMA4"],"Ensembl":"ENSG00000250565","Gene description":"ATPase H+ transporting V1 subunit E2","Uniprot":["Q96A05"],"Chromosome":"2","Position":"46490750-46542577","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"27.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"448.6","Late primary spermatocytes":"324.6","Late spermatids":"344.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"448.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"449","Protein cell type specific Intensity":{"Pancreas epithelial cells":"44881.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA075092"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA075092":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.33e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"ATP6V1F","Gene synonym":["ATP6S14","VATF","Vma7"],"Ensembl":"ENSG00000128524","Gene description":"ATPase H+ transporting V1 subunit F","Uniprot":["Q16864"],"Chromosome":"7","Position":"128862856-128865847","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1063.2","Esophageal suprabasal cells":"1029.7","Hofbauer cells":"1268.8","Late primary spermatocytes":"932.5","Late spermatids":"1415.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1063.2","Mononuclear phagocytes":"1268.8","Spermatogenic cell types":"1415.3","Suprabasal cells":"1029.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Lung - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"26246776.8","Proximal tubules":"31687969.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"59918030.7","cerebral cortex":"107119428.0","kidney":"72260242.7"},"Antibody":["CAB009529","HPA048700","HPA062011"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"19000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":64,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB009529":null,"HPA048700":null,"HPA062011":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.52e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"}},{"Gene":"ATP8A2","Gene synonym":["ATPIB","ML-1"],"Ensembl":"ENSG00000132932","Gene description":"ATPase phospholipid transporting 8A2","Uniprot":["Q9NTI2"],"Chromosome":"13","Position":"25371974-26025851","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted membrane proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"17.8","pituitary gland":"13.6","retina":"13.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"814.7","Brain inhibitory neurons":"644.7","Cone photoreceptor cells":"467.8","Corticotrophs":"656.6","Gonadotrophs":"1438.7","Lactotrophs":"936.6","Other brain neurons":"711.3","Retinal ganglion cells":"969.6","Rod photoreceptor cells":"961.6","Somatotrophs":"918.3","Thyrotrophs":"1198.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"969.6","Pituitary endocrine cells":"1438.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"prostate cancer":"5.2"},"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"22618","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2265763.5","Microglia and Neuropil":"2769450.6","Neurons":"1750246.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"5334552.2"},"Antibody":["HPA039926","HPA040033"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Acrosome","Mid piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Acrosome","Mid piece","Annulus"],"Antibody RRID":{"HPA039926":null,"HPA040033":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ATP8B3","Gene synonym":["ATPIK"],"Ensembl":"ENSG00000130270","Gene description":"ATPase phospholipid transporting 8B3","Uniprot":["O60423"],"Chromosome":"19","Position":"1782075-1812276","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":["Translocase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"5.5","testis":"20.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"14.8","Early spermatids":"10.2","Late primary spermatocytes":"31.9","Late spermatids":"21.9","Monocyte progenitors":"18.7","Neutrophil progenitors":"10.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"18.7","Spermatogenic cell types":"31.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"3.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.85e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.63e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ATPAF2","Gene synonym":["ATP12","Atp12p","LP3663","MGC29736"],"Ensembl":"ENSG00000171953","Gene description":"ATP synthase mitochondrial F1 complex assembly factor 2","Uniprot":["Q8N5M1"],"Chromosome":"17","Position":"17977409-18039209","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"81.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"96.0"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 6: Plasmacytoid dendritic cells - Viral sensing & interferon response","Interactions":78,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA023329":null,"HPA059422":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.71e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"}},{"Gene":"ATRAID","Gene synonym":["APR3","C2orf28","HSPC013","p18"],"Ensembl":"ENSG00000138085","Gene description":"All-trans retinoic acid induced differentiation factor","Uniprot":["Q6UW56"],"Chromosome":"2","Position":"27212041-27217178","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"412.8","Epididymal principal cells":"617.5","Extravillous trophoblasts":"439.8","Late primary spermatocytes":"463.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"617.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"6037135.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"3633820.9","salivary gland":"3655481.0"},"Antibody":["HPA051353"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051353":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"}},{"Gene":"ATRIP","Gene synonym":["FLJ12343","MGC20625","MGC21482","MGC26740"],"Ensembl":"ENSG00000164053","Gene description":"ATR interacting protein","Uniprot":["Q8WXE1"],"Chromosome":"3","Position":"48446710-48467645","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"43.4","Late primary spermatocytes":"68.4","Late spermatids":"53.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"68.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1044446.4","Hepatocytes":"561810.3","Proximal tubules":"830202.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"33","Protein tissue specific Intensity":{"lymphoid tissue":"3329.0"},"Antibody":["CAB033109","HPA047590"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":39,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB033109":null,"HPA047590":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.15e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"}},{"Gene":"ATRNL1","Gene synonym":["ALP","FLJ45344","KIAA0534"],"Ensembl":"ENSG00000107518","Gene description":"Attractin like 1","Uniprot":["Q5VV63"],"Chromosome":"10","Position":"115093365-115948999","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"17.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"1637.9","Brain excitatory neurons":"907.1","Brain inhibitory neurons":"810.0","Choroid plexus epithelial cells":"536.8","Granulosa cells":"403.1","Lactotrophs":"544.3","Oligodendrocyte progenitor cells":"1822.8","Retinal amacrine cells":"1202.8","Retinal bipolar cells":"907.9","Retinal ganglion cells":"733.9","Somatotrophs":"790.4","Thyrotrophs":"458.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"1637.9","Glial cells":"1822.8","Neuronal cells":"1202.8","Pituitary endocrine cells":"790.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"5.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038070":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-3"}},{"Gene":"ATXN2L","Gene synonym":["A2D","A2lp"],"Ensembl":"ENSG00000168488","Gene description":"Ataxin 2 like","Uniprot":["Q8WWM7"],"Chromosome":"16","Position":"28822999-28837237","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"72000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":37,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041506":null,"HPA043391":null,"HPA071955":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.51e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"}},{"Gene":"ATXN7","Gene synonym":["ADCAII","OPCA3","SCA7","SGF73"],"Ensembl":"ENSG00000163635","Gene description":"Ataxin 7","Uniprot":["O15265"],"Chromosome":"3","Position":"63863155-64003462","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"382.1","Neutrophils":"426.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"15.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":49,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA034989":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"}},{"Gene":"ATXN7L1","Gene synonym":["ATXN7L4","KIAA1218","MGC33190"],"Ensembl":"ENSG00000146776","Gene description":"Ataxin 7 like 1","Uniprot":["Q9ULK2"],"Chromosome":"7","Position":"105604772-105876599","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Proximal tubule cells":"372.2","Sertoli cells":"358.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1840","Protein cell type specific Intensity":{"Neurons":"182512.6","T-cells":"185546.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA021448"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":8,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021448":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"AUNIP","Gene synonym":["AIBp","C1orf135","MGC2603"],"Ensembl":"ENSG00000127423","Gene description":"Aurora kinase A and ninein interacting protein","Uniprot":["Q9H7T9"],"Chromosome":"1","Position":"25831913-25859458","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"5.9","testis":"14.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"75.4","Differentiating spermatogonia":"38.8","Early primary spermatocytes":"81.1","Early spermatids":"66.5","Epicardial cells":"47.8","Late primary spermatocytes":"44.0","Late spermatids":"186.0","Oocytes":"78.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"47.8","Myocytes":"75.4","Oocytes":"78.3","Spermatogenic cell types":"186.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":12,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA028730":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.58e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.95e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.64e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"}},{"Gene":"AURKA","Gene synonym":["AIK","ARK1","AurA","BTAK","PPP1R47","STK15","STK6","STK7"],"Ensembl":"ENSG00000087586","Gene description":"Aurora kinase A","Uniprot":["O14965"],"Chromosome":"20","Position":"56369389-56392337","Protein class":["Cancer-related genes","Enzymes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Cilium biogenesis\/degradation","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"20.6","testis":"28.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"49.5","Erythrocyte progenitors":"61.8","Extravillous trophoblasts":"77.4","Late primary spermatocytes":"269.3","Migrating cytotrophoblasts":"57.4","Monocyte progenitors":"90.0","Oocytes":"354.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"354.6","Spermatogenic cell types":"269.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"22170","Protein tissue specific Intensity":{"intestine":"2217027.3"},"Antibody":["CAB001454","HPA002636"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitotic spindle","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":147,"Subcellular main location":["Mitotic spindle","Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"CAB001454":null,"HPA002636":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.02e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.11e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.15e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.47e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"}},{"Gene":"AURKAIP1","Gene synonym":["AIP","AKIP","FLJ20608"],"Ensembl":"ENSG00000175756","Gene description":"Aurora kinase A interacting protein 1","Uniprot":["Q9NWT8"],"Chromosome":"1","Position":"1373730-1375207","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1255.5","Late primary spermatocytes":"1444.9","Late spermatids":"5716.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5716.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1639739.0","liver":"765826.6","salivary gland":"606410.0"},"Antibody":["HPA031821"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":84,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA031821":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.52e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"}},{"Gene":"AURKC","Gene synonym":["ARK3","AurC","STK13"],"Ensembl":"ENSG00000105146","Gene description":"Aurora kinase C","Uniprot":["Q9UQB9"],"Chromosome":"19","Position":"57231009-57235548","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Meiosis","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"44.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"19.7","Early primary spermatocytes":"34.4","Early spermatids":"121.1","Late primary spermatocytes":"290.1","Late spermatids":"26.6","Oocytes":"64.5","Undifferentiated spermatogonia":"21.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"290.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034859"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034859":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.37e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"}},{"Gene":"AXDND1","Gene synonym":["C1orf125","FLJ32940"],"Ensembl":"ENSG00000162779","Gene description":"Axonemal dynein light chain domain containing 1","Uniprot":["Q5T1B0"],"Chromosome":"1","Position":"179365720-179554735","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"33","RNA tissue specific nTPM":{"testis":"14.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"242.0","Ependymal cells":"92.5","Foveolar cells":"62.4","Late primary spermatocytes":"246.0","Late spermatids":"425.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"425.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"90.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Podocytes","Lung - Respiratory ciliated cells","Skin - Sebaceous gland cells","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"8687","Protein cell type specific Intensity":{"Distal tubules":"792641.7","Large ducts":"944783.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA071114"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Primary cilium","Cytosol"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA071114":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"B3GALT4","Gene synonym":["beta3Gal-T4","GalT4"],"Ensembl":"ENSG00000235863","Gene description":"Beta-1,3-galactosyltransferase 4","Uniprot":["O96024"],"Chromosome":"6","Position":"33277123-33284832","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"26.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"6.5","Brain excitatory neurons":"5.2","Brain inhibitory neurons":"3.3","Ependymal cells":"5.7","Loop of henle epithelial cells":"5.5","Microglia":"7.2","Oligodendrocyte progenitor cells":"3.6","Oligodendrocytes":"6.2","Other brain neurons":"5.5","Papillary tip epithelial cells":"14.6","Podocytes":"13.7","Renal collecting duct intercalated cells":"4.0","Renal collecting duct principal cells":"11.2","Renal connecting tubule cells":"3.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"5.7","Ductal cells":"11.2","Glial cells":"7.2","Neuronal cells":"5.5","Renal nephron cells":"14.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"5.8","Stomach Adenocarcinoma (TCGA)":"5.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"45","Protein cell type specific Intensity":{"Pancreatic islets":"4513.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043001"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043001":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"B3GNT5","Gene synonym":["B3GN-T5","beta3Gn-T5"],"Ensembl":"ENSG00000176597","Gene description":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5","Uniprot":["Q9BYG0"],"Chromosome":"3","Position":"183253253-183298504","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Developmental protein","Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"72.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"305.9","Esophageal apical cells":"652.4","Esophageal suprabasal cells":"342.1","Microglia":"316.1","Neutrophils":"584.1","Ocular epithelial cells":"442.4","Syncytiotrophoblasts":"320.7","Urothelial cells":"382.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"652.4","Neutrophils":"584.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"360.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"5.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"5.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":2,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA017292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.32e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.82e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.98e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.15e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.55e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"}},{"Gene":"B4GALNT2","Gene synonym":["Cad","GALGT2","Sda"],"Ensembl":"ENSG00000167080","Gene description":"Beta-1,4-N-acetyl-galactosaminyltransferase 2","Uniprot":["Q8NHY0"],"Chromosome":"17","Position":"49132460-49176840","Protein class":["Disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"31.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"38.8","Enteric transient amplifying cells":"27.3","Enterocytes":"50.0","Gastric chief cells":"32.8","Goblet cells":"72.5","Mucous neck cells":"19.4","Renal collecting duct intercalated cells":"44.4","Renal collecting duct principal cells":"50.5","Salivary ionocytes":"109.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"50.5","Enterocytes":"50.0","Goblet cells":"72.5","Ionocytes":"109.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"1.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"15.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells (progenitors)","Colon - Colon enterocytes","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"6402619.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015721"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015721":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.81e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.85e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"}},{"Gene":"B4GALNT3","Gene synonym":["B4GalNac-T3","FLJ16224","FLJ40362"],"Ensembl":"ENSG00000139044","Gene description":"Beta-1,4-N-acetyl-galactosaminyltransferase 3","Uniprot":["Q6L9W6"],"Chromosome":"12","Position":"459939-563509","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"22.4","stomach 1":"57.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"348.1","Colonocytes":"347.7","Endometrial glandular cells":"546.2","Foveolar cells":"977.2","Ocular epithelial cells":"562.0","Suprabasal keratinocytes":"493.8","Thyrotrophs":"349.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"562.0","Gastric glandular cells":"977.2","Glandular cells":"546.2","Suprabasal cells":"493.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"896284.5","Collecting ducts":"1209684.9","Distal tubules":"2470395.2","Pancreatic islets":"1072197.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011404"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA011404":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.55e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"}},{"Gene":"B9D1","Gene synonym":["B9","EPPB9","MKS9","MKSR-1"],"Ensembl":"ENSG00000108641","Gene description":"B9 domain containing 1","Uniprot":["Q9UPM9"],"Chromosome":"17","Position":"19334308-19378193","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome","Meckel syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"212.9","Epicardial cells":"127.4","Epididymal efferent duct ciliated cells":"177.1","Epididymal principal cells":"132.8","Fallopian tube ciliated cells":"235.6","Late primary spermatocytes":"334.1","Late spermatids":"223.8","Respiratory ciliated cells":"256.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"256.9","Spermatogenic cell types":"334.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"3435700.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"1361615.9"},"Antibody":["HPA022957"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Vesicles","Basal body","Cytosol","Acrosome","Equatorial segment","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":12,"Subcellular main location":["Nucleoplasm","Acrosome","Equatorial segment","Mid piece"],"Subcellular additional location":["Vesicles","Basal body","Cytosol","Principal piece","End piece"],"Antibody RRID":{"HPA022957":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.13e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"}},{"Gene":"BABAM1","Gene synonym":["C19orf62","FLJ20571","HSPC142","MERIT40","NBA1"],"Ensembl":"ENSG00000105393","Gene description":"BRISC and BRCA1 A complex member 1","Uniprot":["Q9NWV8"],"Chromosome":"19","Position":"17267376-17281249","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA repair","Mitosis","Ubl conjugation pathway"],"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"14.9","Bergmann glia":"20.0","Brain excitatory neurons":"27.9","Brain inhibitory neurons":"23.8","Choroid plexus epithelial cells":"10.5","Microglia":"20.2","Oligodendrocyte progenitor cells":"20.2","Oligodendrocytes":"22.2","Other brain neurons":"28.0","Parietal cells":"10.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"22.2","Neuronal cells":"28.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"10069500.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054386","HPA068786","HPA077609"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":21,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA054386":null,"HPA068786":null,"HPA077609":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 18: Adrenal cortex cells - Steroidogensis","Interactions":31,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017926":null,"HPA048867":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.44e-4"}},{"Gene":"BACH1","Gene synonym":["BACH-1","BTBD24"],"Ensembl":"ENSG00000156273","Gene description":"BTB domain and CNC homolog 1","Uniprot":["O14867"],"Chromosome":"21","Position":"29194071-29630751","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"84.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"651.8","monocytes":"779.7","Neutrophils":"948.0","Podocytes":"816.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"948.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"670.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"151.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"151.1","monocytes":"51.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"915425.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"10471","Protein tissue specific Intensity":{"lung":"1671506.4","lymphoid tissue":"422654.9"},"Antibody":["HPA034949"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":54,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA034949":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.45e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"}},{"Gene":"BAG2","Gene synonym":[],"Ensembl":"ENSG00000112208","Gene description":"BAG cochaperone 2","Uniprot":["O95816"],"Chromosome":"6","Position":"57172326-57189833","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"101.3","Decidual stromal cells":"154.4","Early spermatids":"129.0","Late primary spermatocytes":"276.1","Oocytes":"92.1","Smooth muscle cells":"203.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Smooth muscle cells":"203.3","Spermatogenic cell types":"276.1","Stromal cells":"154.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Colon - Smooth muscle cells","Minor Salivary Gland - Endothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"29066274.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"124103166.4"},"Antibody":["HPA018862","HPA019918"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome","Basal body","Cytosol","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":160,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome","Basal body","Mid piece","Principal piece"],"Antibody RRID":{"HPA018862":null,"HPA019918":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.75e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.22e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"}},{"Gene":"BAG5","Gene synonym":[],"Ensembl":"ENSG00000166170","Gene description":"BAG cochaperone 5","Uniprot":["Q9UL15"],"Chromosome":"14","Position":"103556545-103562657","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":["Cardiomyopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"119.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1914.6","Late primary spermatocytes":"638.5","Late spermatids":"2665.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2665.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Minor Salivary Gland - Minor salivary gland basal cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016429"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane","Primary cilium","Primary cilium tip","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":54,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Plasma membrane","Primary cilium","Primary cilium tip","Centrosome","Basal body"],"Antibody RRID":{"HPA016429":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.50e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.55e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"}},{"Gene":"BAG6","Gene synonym":["BAT3","D6S52E","G3","Scythe"],"Ensembl":"ENSG00000204463","Gene description":"BAG cochaperone 6","Uniprot":["P46379"],"Chromosome":"6","Position":"31639028-31652705","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Differentiation","Immunity","Spermatogenesis","Transport"],"Molecular function":["Chaperone","Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"218.9","Late primary spermatocytes":"250.0","Late spermatids":"612.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"612.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB020704","HPA045116","HPA053291"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"260000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":94,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"CAB020704":null,"HPA045116":null,"HPA053291":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"BAP1","Gene synonym":["hucep-6","KIAA0272","UCHL2"],"Ensembl":"ENSG00000163930","Gene description":"BRCA1 associated protein 1","Uniprot":["Q92560"],"Chromosome":"3","Position":"52401008-52410008","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Differentiation","Ubl conjugation pathway"],"Molecular function":["Chromatin regulator","Developmental protein","Hydrolase","Protease","Thiol protease"],"Disease involvement":["Cancer-related genes","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"108.8","Late primary spermatocytes":"65.9","Late spermatids":"61.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"108.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"3907289.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"12992730.8"},"Antibody":["CAB004322","HPA028814","HPA028815","HPA055560"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":139,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB004322":null,"HPA028814":null,"HPA028815":null,"HPA055560":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"}},{"Gene":"BAZ1A","Gene synonym":["ACF1","hACF1","WALp1","WCRF180"],"Ensembl":"ENSG00000198604","Gene description":"Bromodomain adjacent to zinc finger domain 1A","Uniprot":["Q9NRL2"],"Chromosome":"14","Position":"34752731-34875647","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"70.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"760.9","Neutrophil progenitors":"1072.2","Neutrophils":"2072.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2072.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"228.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"29.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"29.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Neutrophils","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"34999251.6","Neutrophils":"19307182.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1419071.8","Stomach":"1013260.9"},"Antibody":["HPA002730"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":39,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA002730":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"}},{"Gene":"BAZ2B","Gene synonym":["WALp4"],"Ensembl":"ENSG00000123636","Gene description":"Bromodomain adjacent to zinc finger domain 2B","Uniprot":["Q9UIF8"],"Chromosome":"2","Position":"159318979-159616569","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"1302.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1302.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"101.9","neutrophil":"197.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"197.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"312124.8","Neutrophils":"1115291.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"8650","Protein tissue specific Intensity":{"intestine":"542157.0","pancreas":"1187837.6"},"Antibody":["HPA019819","HPA059292"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA019819":null,"HPA059292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"}},{"Gene":"BBIP1","Gene synonym":["bA348N5.3","BBIP10","BBS18","NCRNA00081"],"Ensembl":"ENSG00000214413","Gene description":"BBSome interacting protein 1","Uniprot":["A8MTZ0"],"Chromosome":"10","Position":"110898730-110919201","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"95.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"531.4","Late primary spermatocytes":"1004.5","Late spermatids":"695.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1004.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"126","Protein tissue specific Intensity":{"fallopian tube":"12603.8"},"Antibody":["HPA055206","HPA075343"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Nucleoplasm","Basal body","Cytosol"],"Subcellular additional location":["Vesicles","Centrosome"],"Antibody RRID":{"HPA055206":null,"HPA075343":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.28e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"}},{"Gene":"BBOF1","Gene synonym":["C14orf45","CCDC176","FBB10"],"Ensembl":"ENSG00000119636","Gene description":"Basal body orientation factor 1","Uniprot":["Q8ND07"],"Chromosome":"14","Position":"74019349-74082863","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"36.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"231.6","Endometrial ciliated cells":"352.6","Ependymal cells":"264.8","Epididymal efferent duct ciliated cells":"324.0","Fallopian tube ciliated cells":"304.8","Late primary spermatocytes":"418.2","Respiratory ciliated cells":"421.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"421.4","Spermatogenic cell types":"418.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"282.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003090","HPA003136","HPA075108"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Centriolar satellite","Cytosol"],"Antibody RRID":{"HPA003090":null,"HPA003136":null,"HPA075108":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.29e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"}},{"Gene":"BBS12","Gene synonym":["C4orf24","FLJ35630","FLJ41559"],"Ensembl":"ENSG00000181004","Gene description":"Bardet-Biedl syndrome 12","Uniprot":["Q6ZW61"],"Chromosome":"4","Position":"122732702-122744942","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Intellectual disability","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"16.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"27.0","Late primary spermatocytes":"103.5","Respiratory ciliated cells":"24.4","Rod photoreceptor cells":"41.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"41.4","Spermatogenic cell types":"103.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA061856"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA061856":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.00e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.44e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.46e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - 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Adipose progenitor cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1559253.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7521","Protein tissue specific Intensity":{"fallopian tube":"752141.3"},"Antibody":["HPA046125"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium","Basal body","Cytosol","Acrosome","Perinuclear theca"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":26,"Subcellular main location":["Basal body","Cytosol","Acrosome"],"Subcellular additional location":["Primary cilium","Perinuclear theca"],"Antibody RRID":{"HPA046125":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"}},{"Gene":"BBS9","Gene synonym":["B1","PTHB1"],"Ensembl":"ENSG00000122507","Gene description":"Bardet-Biedl syndrome 9","Uniprot":["Q3SYG4"],"Chromosome":"7","Position":"33109557-33877180","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Protein transport","Sensory transduction","Transport","Vision"],"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Intellectual disability","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"908.0","Ependymal cells":"962.2","Lactotrophs":"1852.4","Respiratory ciliated cells":"858.3","Rod photoreceptor cells":"1440.7","Somatotrophs":"1336.9","Thyrotrophs":"1421.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"962.2","Neuronal cells":"1440.7","Pituitary endocrine cells":"1852.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"1945.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":18,"Subcellular main location":["Primary cilium","Primary cilium tip","Primary cilium transition zone","Flagellar centriole","Mid piece","Principal piece"],"Subcellular additional location":["Nucleoplasm","Vesicles","Cytosol","Acrosome","Equatorial segment"],"Antibody RRID":{"HPA021289":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.80e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.35e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"}},{"Gene":"BCAP29","Gene synonym":["BAP29","DKFZp686M2086"],"Ensembl":"ENSG00000075790","Gene description":"B cell receptor associated protein 29","Uniprot":["Q9UHQ4"],"Chromosome":"7","Position":"107580246-107629170","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Apoptosis","ER-Golgi transport","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"55.5","Bergmann glia":"60.7","Brain excitatory neurons":"84.4","Brain inhibitory neurons":"69.3","Choroid plexus epithelial cells":"35.5","Distal convoluted tubule cells":"36.5","Ependymal cells":"39.2","Microglia":"55.1","Oligodendrocyte progenitor cells":"65.4","Oligodendrocytes":"63.1","Other brain neurons":"58.5","Papillary tip epithelial cells":"43.8","Podocytes":"49.6","Renal collecting duct intercalated cells":"83.8","Renal collecting duct principal cells":"41.4","Renal connecting tubule cells":"35.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"39.2","Ductal cells":"83.8","Glial cells":"65.4","Neuronal cells":"84.4","Renal nephron cells":"49.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":11,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA029215":null,"HPA049694":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.96e-7"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.13e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"}},{"Gene":"BCAS2","Gene synonym":["DAM1","Snt309","SPF27"],"Ensembl":"ENSG00000116752","Gene description":"BCAS2 pre-mRNA processing factor","Uniprot":["O75934"],"Chromosome":"1","Position":"114567557-114581629","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oocytes":"409.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA067881"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":148,"Subcellular main location":["Nuclear speckles","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA067881":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"}},{"Gene":"BCHE","Gene synonym":["CHE1","CHE2","E1"],"Ensembl":"ENSG00000114200","Gene description":"Butyrylcholinesterase","Uniprot":["P06276"],"Chromosome":"3","Position":"165772904-165837462","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hydrolase","Serine esterase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"liver":"490.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"60.5","Corticotrophs":"90.0","Hepatocytes":"566.3","Mesothelial cells":"232.5","Oligodendrocyte progenitor cells":"244.6","Smooth muscle cells":"173.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"232.5","Glial cells":"244.6","Hepatocytes":"566.3","Smooth muscle cells":"173.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"92.9","oligodendrocyte precursor cell":"269.3"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"72.4","Kidney Renal Papillary Cell Carcinoma (TCGA)":"18.8","Liver Hepatocellular Carcinoma (TCGA)":"41.4","Skin Cutaneous Melanoma (TCGA)":"40.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Fibroblasts","Liver - Hepatocytes","Minor Salivary Gland - Fibroblasts","Pituitary gland - Corticotropes","Prostate - Smooth muscle cells","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"1209551.8","Microglia and Neuropil":"1554021.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"5527148.5"},"Antibody":["HPA001560"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":3820000000,"Blood concentration - Conc. blood MS [pg\/L]":"1800000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA001560":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.23e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"}},{"Gene":"BCKDHA","Gene synonym":["MSU","OVD1A"],"Ensembl":"ENSG00000248098","Gene description":"Branched chain keto acid dehydrogenase E1 subunit alpha","Uniprot":["P12694"],"Chromosome":"19","Position":"41397808-41425002","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Maple syrup urine disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"8.5","Bergmann glia":"10.9","Brain excitatory neurons":"7.8","Brain inhibitory neurons":"7.4","Esophageal apical cells":"12.2","Foveolar cells":"7.5","Microglia":"7.9","Oligodendrocyte progenitor cells":"9.6","Oligodendrocytes":"9.3","Other brain neurons":"8.8","Parietal cells":"10.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"12.2","Glial cells":"10.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Stomach - Parietal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"123168207.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036640"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9700","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":32,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036640":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.94e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"}},{"Gene":"BCL2L1","Gene synonym":["Bcl-X","bcl-xL","bcl-xS","BCL2L","BCLX","PPP1R52"],"Ensembl":"ENSG00000171552","Gene description":"BCL2 like 1","Uniprot":["Q07817"],"Chromosome":"20","Position":"31664452-31723989","Protein class":["Cancer-related genes","Essential proteins","Predicted membrane proteins","RAS pathway related proteins","Transporters"],"Biological process":["Apoptosis","Endocytosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"389.3","Esophageal apical cells":"415.4","Platelets":"420.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"299.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"4737823.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035734","CAB072801"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Mitochondria","Acrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":83,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli fibrillar center","Acrosome"],"Antibody RRID":{"CAB072801":null,"HPA035734":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.09e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.57e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"}},{"Gene":"BCL2L11","Gene synonym":["BIM","BimEL","BimL","BimS","BOD"],"Ensembl":"ENSG00000153094","Gene description":"BCL2 like 11","Uniprot":["O43521"],"Chromosome":"2","Position":"111119378-111168445","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"155.9","Plasma cells":"364.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Plasma cells":"364.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"43.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"11938217.5","T-cells":"11456080.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1632720.3"},"Antibody":["CAB026332","CAB079899"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":44,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB026332":null,"CAB079899":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.77e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"}},{"Gene":"BCL2L14","Gene synonym":["BCL-G","BCLG"],"Ensembl":"ENSG00000121380","Gene description":"BCL2 like 14","Uniprot":["Q9BZR8"],"Chromosome":"12","Position":"12049844-12211084","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"14.5","stomach 1":"8.8","testis":"29.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"38.5","Bergmann glia":"38.5","Brain excitatory neurons":"29.9","Brain inhibitory neurons":"26.4","Distal convoluted tubule cells":"33.3","Early spermatids":"85.7","Ependymal cells":"38.4","Late primary spermatocytes":"40.4","Late spermatids":"275.6","Loop of henle epithelial cells":"40.2","Oligodendrocyte progenitor cells":"44.2","Oligodendrocytes":"47.9","Other brain neurons":"31.7","Papillary tip epithelial cells":"37.0","Renal collecting duct intercalated cells":"26.9","Renal collecting duct principal cells":"27.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"275.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"10.6","Pancreatic Adenocarcinoma (TCGA)":"4.0","Rectum Adenocarcinoma (TCGA)":"10.4","Stomach Adenocarcinoma (TCGA)":"7.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"18.8","colorectal cancer":"6.4"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":33,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA040665":null,"HPA059846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.93e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029732":null,"HPA029733":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"BCL7C","Gene synonym":["SMARCJ3"],"Ensembl":"ENSG00000099385","Gene description":"BAF chromatin remodeling complex subunit BCL7C","Uniprot":["Q8WUZ0"],"Chromosome":"16","Position":"30833626-30894302","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":37,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA018676":null,"HPA052654":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"BDNF","Gene synonym":[],"Ensembl":"ENSG00000176697","Gene description":"Brain derived neurotrophic factor","Uniprot":["P23560"],"Chromosome":"11","Position":"27654893-27722058","Protein class":["Cancer-related genes","Human disease related genes","Plasma proteins","Predicted membrane proteins","Predicted secreted proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"56.9","Brain excitatory neurons":"63.7","Cardiomyocytes":"78.4","Corticotrophs":"74.4","Epicardial cells":"59.1","Epididymal principal cells":"56.1","Granulosa cells":"27.6","Megakaryocytes":"37.1","Myonuclei":"29.4","Retinal bipolar cells":"30.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"56.9","Barrier epithelial cells":"59.1","Myocytes":"78.4","Neuronal cells":"63.7","Pituitary endocrine cells":"74.4","Reproductive supporting cells":"56.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"336.0","mammillary body":"126.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"27.6"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 1","Minor Salivary Gland - Minor salivary gland basal cells","Prostate - Smooth muscle cells","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"88932.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"5671","Protein tissue specific Intensity":{"cerebral cortex":"670129.8","lymphoid tissue":"463982.4"},"Antibody":["CAB009564"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Growth factor","CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":16000000,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB009564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BDP1","Gene synonym":["HSA238520","KIAA1241","KIAA1689","TAF3B1","TFC5","TFIIIB150","TFIIIB90","TFNR"],"Ensembl":"ENSG00000145734","Gene description":"B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB","Uniprot":["A6H8Y1"],"Chromosome":"5","Position":"71455651-71567820","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator"],"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"197.3","Proximal tubule cells":"196.7","Renal collecting duct intercalated cells":"219.5","Renal connecting tubule cells":"184.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"219.5","Renal nephron cells":"197.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA064166":null,"HPA077984":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BEAN1","Gene synonym":["SCA31"],"Ensembl":"ENSG00000166546","Gene description":"Brain expressed associated with NEDD4 1","Uniprot":["Q3B7T3"],"Chromosome":"16","Position":"66427295-66493529","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"3.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"43.4","Early spermatids":"51.2","Epicardial cells":"40.9","Extravillous trophoblasts":"36.1","Retinal ganglion cells":"108.2","Retinal horizontal cells":"38.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"108.2","Spermatogenic cell types":"51.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"4.8"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA053851":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BEND7","Gene synonym":["C10orf30","FLJ40283"],"Ensembl":"ENSG00000165626","Gene description":"BEN domain containing 7","Uniprot":["Q8N7W2"],"Chromosome":"10","Position":"13438484-13529014","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"254.6","Epididymal efferent duct absorptive cells":"230.9","Late spermatids":"512.3","Pituitary stem cells":"229.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"512.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"198826.1","Fallopian tube cells":"346505.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"286556.6"},"Antibody":["HPA037835"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":8,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA037835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.94e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"}},{"Gene":"BEST3","Gene synonym":["MGC13168","MGC40411","VMD2L3"],"Ensembl":"ENSG00000127325","Gene description":"Bestrophin 3","Uniprot":["Q8N1M1"],"Chromosome":"12","Position":"69643360-69699476","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"skeletal muscle":"66.8","tongue":"52.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"123.1","Corticotrophs":"48.4","Myonuclei":"509.6","Myosatellite cells":"141.8","Oligodendrocyte progenitor cells":"86.0","Respiratory ionocytes":"66.0","Thymic myoid cells":"373.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"509.6","Stem cells":"141.8","Stromal cells":"373.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"109.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"14.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"34.8"},"RNA tissue cell type enrichment":["Pancreas - Beta cells","Pituitary gland - Corticotropes","Prostate - Prostate glandular cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054582"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054582":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.33e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.85e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BIN2","Gene synonym":["BRAP-1"],"Ensembl":"ENSG00000110934","Gene description":"Bridging integrator 2","Uniprot":["Q9UBW5"],"Chromosome":"12","Position":"51281038-51324668","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"95.7","lymphoid tissue":"48.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"153.0","Extravillous trophoblasts":"293.3","Megakaryocytes":"531.6","Microglia":"175.4","monocytes":"163.2","Neutrophil progenitors":"389.9","Neutrophils":"547.9","NK-cells":"339.3","Platelets":"1232.5","Syncytiotrophoblasts":"191.6","T-cells":"172.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"531.6","Neutrophils":"547.9","NK-cells":"339.3","Platelets":"1232.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"98","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"205.0","leukocyte":"201.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Leukemia":"55.4","Myeloma":"48.7"},"RNA tissue cell type enrichment":["Adrenal gland - Macrophages","Lung - Neutrophils_2","Spleen - Neutrophils_2","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"3700008.4","Macrophages":"6646342.1","Neutrophils":"5702078.7","T-cells":"13955830.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"17350876.5","lymphoid tissue":"26138223.1"},"Antibody":["HPA038666","HPA038667"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"20000000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":4,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA038666":null,"HPA038667":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"}},{"Gene":"BIRC5","Gene synonym":["API4","EPR-1","survivin"],"Ensembl":"ENSG00000089685","Gene description":"Baculoviral IAP repeat containing 5","Uniprot":["O15392"],"Chromosome":"17","Position":"78214186-78225636","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis","Cell cycle","Cell division","Chromosome partition","Host-virus interaction","Mitosis","Transcription","Transcription regulation"],"Molecular function":["Protease inhibitor","Repressor","Thiol protease inhibitor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"35.8","lymphoid tissue":"38.1","testis":"18.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"83.9","Differentiating spermatogonia":"100.9","Early primary spermatocytes":"111.0","Early spermatids":"75.5","Enteric transient amplifying cells":"105.2","Erythrocyte progenitors":"154.8","Esophageal basal cells":"169.3","Extravillous trophoblasts":"178.1","Gastric progenitor cells":"115.4","Hofbauer cells":"76.9","Late primary spermatocytes":"284.0","Late spermatids":"95.3","Megakaryocyte progenitors":"121.8","Megakaryocytes":"92.7","Migrating cytotrophoblasts":"140.7","Monocyte progenitors":"135.3","Oocytes":"124.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"169.3","Erythrocytes":"154.8","Megakaryocytes":"121.8","Mononuclear phagocytes":"135.3","Oocytes":"124.3","Spermatogenic cell types":"284.0","Trophoblast cells":"178.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"1.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"14.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"T-cells":"14.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"216","Protein tissue specific Intensity":{"bone marrow":"21611.4"},"Antibody":["HPA002830","CAB004270"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytokinetic bridge"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":57,"Subcellular main location":["Cytokinetic bridge"],"Subcellular additional location":null,"Antibody RRID":{"CAB004270":null,"HPA002830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.12e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.21e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.21e-12"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.71e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.42e-10"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.12e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.52e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"}},{"Gene":"BLTP3A","Gene synonym":["C6orf107","dJ349A12.1","FLJ20302","UHRF1BP1"],"Ensembl":"ENSG00000065060","Gene description":"Bridge-like lipid transfer protein family member 3A","Uniprot":["Q6BDS2"],"Chromosome":"6","Position":"34792083-34877514","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"120.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"1117410.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"2970550.2"},"Antibody":["HPA032099","HPA032100"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":8,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA032099":null,"HPA032100":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.81e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"BLTP3B","Gene synonym":["KIAA0701","SHIP164","UHRF1BP1L"],"Ensembl":"ENSG00000111647","Gene description":"Bridge-like lipid transfer protein family member 3B","Uniprot":["A0JNW5"],"Chromosome":"12","Position":"100028455-100142874","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"481.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"481.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2024175.6","Fallopian tube cells":"6315889.8","Macrophages":"2426118.5","Microglia and Neuropil":"4555884.7","Neurons":"6125068.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"4672574.2"},"Antibody":["HPA039671","HPA075150"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA039671":null,"HPA075150":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.12e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"}},{"Gene":"BLZF1","Gene synonym":["JEM-1"],"Ensembl":"ENSG00000117475","Gene description":"Basic leucine zipper nuclear factor 1","Uniprot":["Q9H2G9"],"Chromosome":"1","Position":"169367970-169396540","Protein class":["Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal basal cells":"180.1","Esophageal apical cells":"314.0","Late primary spermatocytes":"180.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"314.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"85.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":102,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA025703":null,"HPA027331":null,"HPA067113":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.56e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.03e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"BMERB1","Gene synonym":["C16orf45","FLJ32618"],"Ensembl":"ENSG00000166780","Gene description":"BMERB domain containing 1","Uniprot":["Q96MC5"],"Chromosome":"16","Position":"15434475-15625028","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"190.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"69.0","Brain excitatory neurons":"129.8","Brain inhibitory neurons":"116.3","Choroid plexus epithelial cells":"73.3","Distal convoluted tubule cells":"125.1","Early spermatids":"77.0","Late primary spermatocytes":"62.4","Late spermatids":"312.9","Oligodendrocyte progenitor cells":"156.3","Oligodendrocytes":"92.6","Other brain neurons":"126.5","Papillary tip epithelial cells":"72.6","Podocytes":"95.5","Renal connecting tubule cells":"66.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"156.3","Neuronal cells":"129.8","Renal nephron cells":"125.1","Spermatogenic cell types":"312.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"94.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"8.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"B-cells":"2.2","T-cells":"8.8"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"69.1"},"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"818488.7","Microglia and Neuropil":"1947888.2","Neurons":"1215117.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"82816","Protein tissue specific Intensity":{"cerebral cortex":"8281631.2"},"Antibody":["HPA041114","HPA063757"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 27: T-cells - Unknown function","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041114":null,"HPA063757":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.98e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.20e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.84e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.89e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"}},{"Gene":"BMP2K","Gene synonym":["BIKe","DKFZp434K0614"],"Ensembl":"ENSG00000138756","Gene description":"BMP2 inducible kinase","Uniprot":["Q9NSY1"],"Chromosome":"4","Position":"78776342-78916365","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"433.2","Erythrocyte progenitors":"387.5","Hofbauer cells":"630.6","Mast cells":"822.1","Megakaryocyte progenitors":"438.5","Megakaryocyte-Erythroid progenitors":"473.9","Microglia":"1141.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1141.1","Mast cells":"822.1","Mononuclear phagocytes":"630.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1593.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":42,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA026436":null,"HPA026451":null,"HPA026501":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.20e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"}},{"Gene":"BNC1","Gene synonym":["BNC","HsT19447"],"Ensembl":"ENSG00000169594","Gene description":"Basonuclin 1","Uniprot":["Q01954"],"Chromosome":"15","Position":"83255884-83284664","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Premature ovarian failure"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"14.2","esophagus":"12.0","testis":"23.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"118.7","Early spermatids":"42.0","Epicardial cells":"154.6","Epididymal basal cells":"54.3","Esophageal basal cells":"54.9","Late primary spermatocytes":"52.1","Late spermatids":"180.8","Mesothelial cells":"356.3","Ocular epithelial cells":"71.7","Suprabasal keratinocytes":"71.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"356.3","Basal cells":"118.7","Spermatogenic cell types":"180.8","Suprabasal cells":"71.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"1.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"19.1","Head and Neck Squamous Cell Carcinoma (TCGA)":"37.9","Lung Squamous Cell Carcinoma (TCGA)":"13.0","Testicular Germ Cell Tumor (TCGA)":"15.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"29.8"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA063183":null,"HPA077428":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.10e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BNIP1","Gene synonym":["Nip1","SEC20"],"Ensembl":"ENSG00000113734","Gene description":"BCL2 interacting protein 1","Uniprot":["Q12981"],"Chromosome":"5","Position":"173144442-173164387","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Apoptosis","ER-Golgi transport","Host-virus interaction","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"50.9","Oocytes":"78.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"78.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"20455867.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"103976994.4"},"Antibody":["HPA008009","HPA008149"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":72,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA008009":null,"HPA008149":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.50e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"BOD1L2","Gene synonym":["BOD1P","FAM44C","MGC33608"],"Ensembl":"ENSG00000228075","Gene description":"Biorientation of chromosomes in cell division 1 like 2","Uniprot":["Q8IYS8"],"Chromosome":"18","Position":"57147087-57150410","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"1044","RNA tissue specific nTPM":{"testis":"253.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"8773.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"438","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"8773.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036293":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BOLL","Gene synonym":["BOULE"],"Ensembl":"ENSG00000152430","Gene description":"Boule homolog, RNA binding protein","Uniprot":["Q8N9W6"],"Chromosome":"2","Position":"197726879-197786762","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Translation regulation"],"Molecular function":["Developmental protein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"45.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early primary spermatocytes":"217.2","Early spermatids":"137.4","Late primary spermatocytes":"508.0","Late spermatids":"184.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"508.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"T-reg":"1.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"T-cells":"1.5"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":["Annulus"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA018678":null,"HPA048813":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BORCS6","Gene synonym":["C17orf59","FLJ20014"],"Ensembl":"ENSG00000196544","Gene description":"BLOC-1 related complex subunit 6","Uniprot":["Q96GS4"],"Chromosome":"17","Position":"8188345-8190180","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"42.7","Platelets":"109.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"109.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5500","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 18: Non-specific - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":99,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA045415":null,"HPA060791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.54e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"BPGM","Gene synonym":[],"Ensembl":"ENSG00000172331","Gene description":"Bisphosphoglycerate mutase","Uniprot":["P07738"],"Chromosome":"7","Position":"134646811-134679816","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Glycolysis"],"Molecular function":["Hydrolase","Isomerase"],"Disease involvement":["Congenital erythrocytosis","Disease variant","Hereditary hemolytic anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"82.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Erythrocytes":"313.0","Oocytes":"483.5","Syncytiotrophoblasts":"559.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Erythrocytes":"313.0","Oocytes":"483.5","Trophoblast cells":"559.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Erythrocytes","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"86781909.0","Oocytes":"69384406.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016493","HPA028735"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"28000000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 13: Syncytiotrophoblasts - Placental remodeling & endocrine func.","Interactions":7,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA016493":null,"HPA028735":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.32e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"BPI","Gene synonym":["BPIFD1"],"Ensembl":"ENSG00000101425","Gene description":"Bactericidal permeability increasing protein","Uniprot":["P17213"],"Chromosome":"20","Position":"38304150-38337505","Protein class":["Predicted intracellular proteins","Predicted secreted proteins","Transporters"],"Biological process":["Immunity","Innate immunity"],"Molecular function":["Antibiotic","Antimicrobial"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"87","RNA tissue specific nTPM":{"bone marrow":"1420.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"250.8","Late spermatids":"293.8","Neutrophil progenitors":"848.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"49","RNA single cell type group specific nCPM":{"Neutrophils":"848.7","Spermatogenic cell types":"293.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"fibroblast":"3.8","pericyte":"1.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"17","RNA blood cell specific nTPM":{"classical monocyte":"14.5","neutrophil":"7.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"granulocytes":"7.1","monocytes":"14.5"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Leukemia":"20.4"},"RNA tissue cell type enrichment":["Liver - Erythroid cells","Lung - Neutrophils_1","Prostate - Fibroblasts","Spleen - Neutrophils_1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"593739030.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"138094585.8","lymphoid tissue":"34758542.4"},"Antibody":["HPA061284"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Immunity","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":7290000,"Blood concentration - Conc. blood MS [pg\/L]":"45000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA061284":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.63e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BPIFB1","Gene synonym":["bA49G10.6","C20orf114","dJ1187J4.1","LPLUNC1","MGC14597","VEMSGP"],"Ensembl":"ENSG00000125999","Gene description":"BPI fold containing family B member 1","Uniprot":["Q8TDL5"],"Chromosome":"20","Position":"33273480-33309871","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"cervix":"532.0","salivary gland":"255.4","stomach 1":"483.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Conjunctival goblet cells":"13860.0","Respiratory deuterosomal cells":"7937.4","Respiratory secretory cells":"9172.4","Submucosal glandular cells":"5146.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Ciliated cells":"7937.4","Glandular cells":"5146.7","Goblet cells":"13860.0","Secretory cells":"9172.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"1.2","medium spiny neuron":"1.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"179.4","Stomach Adenocarcinoma (TCGA)":"201.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"breast cancer":"122.7"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5200000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024256":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"}},{"Gene":"BPIFC","Gene synonym":["BPIL2","dJ149A16.7"],"Ensembl":"ENSG00000184459","Gene description":"BPI fold containing family C","Uniprot":["Q8NFQ6"],"Chromosome":"22","Position":"32413845-32464484","Protein class":["Predicted secreted proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"19","RNA tissue specific nTPM":{"skin 1":"42.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"24.0","Late primary spermatocytes":"17.7","Late spermatids":"12.7","Suprabasal keratinocytes":"10.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"24.0","Suprabasal cells":"10.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"3.7","Skin Cutaneous Melanoma (TCGA)":"4.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"16","RNA blood cell specific nTPM":{"basophil":"1.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"16","RNA blood lineage specific nTPM":{"granulocytes":"1.5"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BRAF","Gene synonym":["BRAF-1","BRAF1"],"Ensembl":"ENSG00000157764","Gene description":"B-Raf proto-oncogene, serine\/threonine kinase","Uniprot":["P15056"],"Chromosome":"7","Position":"140719327-140924929","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":["Allosteric enzyme","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes","Cardiomyopathy","Deafness","Disease variant","Ectodermal dysplasia","FDA approved drug targets","Intellectual disability","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"2034.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2034.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - Endothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"4463095.3","Microglia and Neuropil":"3953113.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"663710.3","cerebral cortex":"1522106.4","Stomach":"994163.0"},"Antibody":["HPA001328","CAB004552","HPA071048","CAB080447","CAB080451","CAB080452","CAB080531"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Plasma membrane","Primary cilium","Centriolar satellite","Basal body","Cytosol","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":174,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":["Plasma membrane","Primary cilium","Centriolar satellite","Basal body","Mid piece","Principal piece","End piece"],"Antibody RRID":{"CAB004552":null,"CAB080447":null,"CAB080451":null,"CAB080452":null,"CAB080531":null,"HPA001328":null,"HPA071048":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.52e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.24e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"}},{"Gene":"BRAP","Gene synonym":["BRAP2","IMP","RNF52"],"Ensembl":"ENSG00000089234","Gene description":"BRCA1 associated protein","Uniprot":["Q7Z569"],"Chromosome":"12","Position":"111642146-111685956","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"63.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"278.6","Late primary spermatocytes":"390.6","Late spermatids":"600.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"600.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"1083859.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040357","HPA058820"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":23,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA040357":null,"HPA058820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.17e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.55e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.10e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"}},{"Gene":"BRD3OS","Gene synonym":["bA374P20.3","FLJ35348","LINC00094","NCRNA00094","SERLOC"],"Ensembl":"ENSG00000235106","Gene description":"BRD3 opposite strand","Uniprot":["A0A1B0GUI7"],"Chromosome":"9","Position":"134025481-134034666","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"49.1","Platelets":"83.3","Respiratory ciliated cells":"46.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"83.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"17","Protein tissue specific Intensity":{"cerebral cortex":"1717.5"},"Antibody":["HPA045437"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":null,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA045437":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.06e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.56e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.25e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"}},{"Gene":"BRD8","Gene synonym":["p120","SMAP"],"Ensembl":"ENSG00000112983","Gene description":"Bromodomain containing 8","Uniprot":["Q9H0E9"],"Chromosome":"5","Position":"138139770-138178953","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Growth regulation","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"220.7","Late primary spermatocytes":"315.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"315.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1294194.1","fallopian tube":"4918588.1","lymphoid tissue":"1489679.7","ovary":"4073442.7"},"Antibody":["HPA001841"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":50,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA001841":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.06e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.88e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.48e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.57e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"BRDT","Gene synonym":["BRD6","CT9"],"Ensembl":"ENSG00000137948","Gene description":"Bromodomain testis associated","Uniprot":["Q58F21"],"Chromosome":"1","Position":"91949343-92014426","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","mRNA processing","mRNA splicing","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"48","RNA tissue specific nTPM":{"testis":"122.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"1248.0","Late primary spermatocytes":"1641.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1641.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"22.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"1.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Esophageal cancer":"9.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB012237":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"}},{"Gene":"BRINP2","Gene synonym":["DBCCR1L2","FAM5B"],"Ensembl":"ENSG00000198797","Gene description":"BMP\/retinoic acid inducible neural specific 2","Uniprot":["Q9C0B6"],"Chromosome":"1","Position":"177170958-177282422","Protein class":["Predicted secreted proteins","Transporters"],"Biological process":["Cell cycle","Growth arrest"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"adrenal gland":"8.5","brain":"27.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"53.7","Adrenal medulla cells":"74.5","Astrocytes":"175.9","Brain excitatory neurons":"112.7","Brain inhibitory neurons":"75.5","Epicardial cells":"38.7","Gonadotrophs":"60.8","Mesothelial cells":"34.4","Microglia":"34.1","Oligodendrocyte progenitor cells":"139.9","Oligodendrocytes":"37.9","Other brain neurons":"59.2","Pituitary stem cells":"116.9","Retinal amacrine cells":"43.4","Retinal horizontal cells":"34.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"74.5","Glial cells":"175.9","Neuronal cells":"112.7","Pituitary endocrine cells":"60.8","Stem cells":"116.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"15.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA050681":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054693":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":27,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA005474":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"}},{"Gene":"BRK1","Gene synonym":["C3orf10","HSPC300","MDS027"],"Ensembl":"ENSG00000254999","Gene description":"BRICK1 subunit of SCAR\/WAVE actin nucleating complex","Uniprot":["Q8WUW1"],"Chromosome":"3","Position":"10115675-10127190","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1131.1","Esophageal apical cells":"1839.9","Esophageal suprabasal cells":"870.9","Late spermatids":"3909.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1839.9","Spermatogenic cell types":"3909.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"88000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":71,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA060391":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.81e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.94e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.59e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"}},{"Gene":"BRMS1","Gene synonym":["DKFZP564A063"],"Ensembl":"ENSG00000174744","Gene description":"BRMS1 transcriptional repressor and anoikis regulator","Uniprot":["Q9HCU9"],"Chromosome":"11","Position":"66337333-66345125","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Apoptosis","Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":["Cancer-related genes","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"129.2","Oocytes":"124.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"2499852.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5150","Protein tissue specific Intensity":{"lymphoid tissue":"515045.2"},"Antibody":["CAB010824","HPA019637"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":50,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"CAB010824":null,"HPA019637":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.73e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.86e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"}},{"Gene":"BSCL2","Gene synonym":["GNG3LG","seipin","SPG17"],"Ensembl":"ENSG00000168000","Gene description":"BSCL2 lipid droplet biogenesis associated, seipin","Uniprot":["Q96G97"],"Chromosome":"11","Position":"62689289-62709845","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":null,"Disease involvement":["Congenital generalized lipodystrophy","Diabetes mellitus","Disease variant","Hereditary spastic paraplegia","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"274.6","pituitary gland":"219.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"3.6","Early primary spermatocytes":"4.5","Early spermatids":"3.6","Epididymal principal cells":"4.3","Late primary spermatocytes":"7.0","Late spermatids":"13.8","Oocytes":"4.6","Parietal cells":"3.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"4.6","Reproductive supporting cells":"4.3","Spermatogenic cell types":"13.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Kidney - Fibroblasts","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"26333114.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"6365124.3"},"Antibody":["HPA042394"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":29,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"}},{"Gene":"BSX","Gene synonym":["BSX1"],"Ensembl":"ENSG00000188909","Gene description":"Brain specific homeobox","Uniprot":["Q3C1V8"],"Chromosome":"11","Position":"122977570-122981834","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Foveolar cells":"1.0","Other brain neurons":"1.7","pDCs":"1.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"1.3","Gastric glandular cells":"1.0","Neuronal cells":"1.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"7","RNA brain regional specific nTPM":{"hypothalamus":"24.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"hypothalamus":"4.5"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"10","RNA pig brain regional specific nTPM":{"hypothalamus":"4.4"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015654"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015654":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":59,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA024263":null,"HPA067671":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.66e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"}},{"Gene":"BTBD10","Gene synonym":["GMRP-1","GMRP1","MGC13007"],"Ensembl":"ENSG00000148925","Gene description":"BTB domain containing 10","Uniprot":["Q9BSF8"],"Chromosome":"11","Position":"13388008-13463297","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"15428086.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"323","Protein tissue specific Intensity":{"cerebral cortex":"32335.8"},"Antibody":["HPA046777"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":5,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA046777":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.26e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.43e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"}},{"Gene":"BTBD16","Gene synonym":["C10orf87","Em:AC061711.1","FLJ25359"],"Ensembl":"ENSG00000138152","Gene description":"BTB domain containing 16","Uniprot":["Q32M84"],"Chromosome":"10","Position":"122271296-122338159","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skin 1":"7.9","testis":"7.3","urinary bladder":"18.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"54.9","Early spermatids":"118.9","Late primary spermatocytes":"87.8","Late spermatids":"86.3","Papillary tip epithelial cells":"29.4","Urothelial cells":"255.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"54.9","Barrier epithelial cells":"255.7","Spermatogenic cell types":"118.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"16.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"15.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"4.2","pancreatic cancer":"5.1"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040529":null,"HPA057638":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031355"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA031355":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.06e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"}},{"Gene":"BTBD8","Gene synonym":["APache","KIAA1107"],"Ensembl":"ENSG00000189195","Gene description":"BTB domain containing 8","Uniprot":["Q5XKL5","Q9UPP5"],"Chromosome":"1","Position":"92080305-92184725","Protein class":["Predicted intracellular proteins"],"Biological process":["Endocytosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"12.6","retina":"16.7","testis":"4.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"140.8","Retinal amacrine cells":"197.0","Retinal bipolar cells":"212.0","Somatotrophs":"119.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"212.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"476.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"Gallbladder cancer":"10.5"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3222829.5","Microglia and Neuropil":"5887121.9","Neurons":"9228187.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"9955110.4"},"Antibody":["HPA024216","HPA035311"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA024216":null,"HPA035311":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.42e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BTG4","Gene synonym":["APRO3","PC3B"],"Ensembl":"ENSG00000137707","Gene description":"BTG anti-proliferation factor 4","Uniprot":["Q9NY30"],"Chromosome":"11","Position":"111467526-111514367","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"21.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"33.5","Early spermatids":"115.4","Ependymal cells":"30.9","Late primary spermatocytes":"146.5","Late spermatids":"280.3","Respiratory ciliated cells":"54.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"280.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"15","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"17.4","ependymal cell":"38.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"10.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA057157"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":1,"Subcellular main location":["Endoplasmic reticulum","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA057157":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"BUB3","Gene synonym":["BUB3L"],"Ensembl":"ENSG00000154473","Gene description":"BUB3 mitotic checkpoint protein","Uniprot":["O43684"],"Chromosome":"10","Position":"123154402-123170467","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Chromosome partition","Meiosis","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"279.3","Late spermatids":"232.1","Oocytes":"391.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"391.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":43,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB037075":null,"HPA003601":null,"HPA071982":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.14e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.00e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038340":null,"HPA038341":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.88e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"}},{"Gene":"BUD31","Gene synonym":["Cwc14","EDG-2","EDG2","fSAP17","G10","YCR063W"],"Ensembl":"ENSG00000106245","Gene description":"BUD31 homolog","Uniprot":["P41223"],"Chromosome":"7","Position":"99408641-99419616","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"511.8","Late primary spermatocytes":"485.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"511.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":16,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Microtubules","Centrosome"],"Antibody RRID":{"HPA028943":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.02e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.39e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"}},{"Gene":"BVES","Gene synonym":["HBVES","POP1","POPDC1"],"Ensembl":"ENSG00000112276","Gene description":"Blood vessel epicardial substance","Uniprot":["Q8NE79"],"Chromosome":"6","Position":"105096822-105137157","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Cell adhesion"],"Molecular function":["Developmental protein"],"Disease involvement":["Limb-girdle muscular dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"26.0","skeletal muscle":"41.0","tongue":"27.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"46.0","Early spermatids":"30.7","Late primary spermatocytes":"57.0","Late spermatids":"93.9","Myonuclei":"119.5","Myosatellite cells":"22.1","Pituicytes\/FSCs":"25.8","Smooth muscle cells":"23.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"119.5","Spermatogenic cell types":"93.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"25.0","oligodendrocyte":"23.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"16.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Prostate - Smooth muscle cells","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"1438251.9","Cardiomyocytes":"4113782.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"7699249.8"},"Antibody":["HPA014788","HPA018176"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":2,"Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA014788":null,"HPA018176":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"}},{"Gene":"BZW1","Gene synonym":["5MP2","BZAP45","KIAA0005"],"Ensembl":"ENSG00000082153","Gene description":"Basic leucine zipper and W2 domains 1","Uniprot":["Q7L1Q6"],"Chromosome":"2","Position":"200810594-200827338","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Translation regulation"],"Molecular function":["Activator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"2864.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2864.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047288","HPA053272"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":9,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA047288":null,"HPA053272":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.90e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.03e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.18e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"}},{"Gene":"C10orf105","Gene synonym":["FLJ00245"],"Ensembl":"ENSG00000214688","Gene description":"Chromosome 10 open reading frame 105","Uniprot":["Q8TEF2"],"Chromosome":"10","Position":"71711701-71737824","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"12.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"10.7","cDC":"9.9","Early spermatids":"11.0","Ependymal cells":"48.4","Erythrocyte progenitors":"12.5","Late spermatids":"7.4","M\u00fcller glia":"12.0","Neutrophils":"22.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"48.4","Erythrocytes":"12.5","Glial cells":"12.0","Neutrophils":"22.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"ependymal cell":"66.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"1.8","non-classical monocyte":"2.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C10orf120","Gene synonym":["bA318C4.1"],"Ensembl":"ENSG00000183559","Gene description":"Chromosome 10 open reading frame 120","Uniprot":["Q5SQS8"],"Chromosome":"10","Position":"122697709-122699846","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"161","RNA tissue specific nTPM":{"testis":"29.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"809.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"515","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"809.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037951":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":3,"Subcellular main location":["Vesicles","Microtubules","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038131":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA038648":null,"HPA075229":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C11orf1","Gene synonym":["FLJ23499"],"Ensembl":"ENSG00000137720","Gene description":"Chromosome 11 open reading frame 1","Uniprot":["Q9H5F2"],"Chromosome":"11","Position":"111878935-111885975","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1840.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1840.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038410":null,"HPA057519":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.01e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.33e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"}},{"Gene":"C11orf16","Gene synonym":[],"Ensembl":"ENSG00000176029","Gene description":"Chromosome 11 open reading frame 16","Uniprot":["Q9NQ32"],"Chromosome":"11","Position":"8920076-8933006","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"13.3","fallopian tube":"12.1","lymphoid tissue":"5.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"42.8","Endometrial ciliated cells":"64.6","Ependymal cells":"65.5","Epididymal efferent duct ciliated cells":"60.4","Fallopian tube ciliated cells":"94.0","Respiratory ciliated cells":"240.4","Respiratory ionocytes":"236.2","Salivary ionocytes":"92.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Ciliated cells":"240.4","Ionocytes":"236.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"54","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"31.3","ependymal cell":"70.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"1.6","Uterine Corpus Endometrial Carcinoma (TCGA)":"2.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"13.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA040644":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"}},{"Gene":"C11orf52","Gene synonym":["FLJ25219","MGC14839"],"Ensembl":"ENSG00000149300","Gene description":"Chromosome 11 open reading frame 52","Uniprot":["Q96A22"],"Chromosome":"11","Position":"111918032-111926871","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1.5","Brain excitatory neurons":"1.8","Choroid plexus epithelial cells":"5.0","Ependymal cells":"1.7","Oligodendrocytes":"1.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Ciliated cells":"5.0","Glial cells":"1.5","Neuronal cells":"1.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"9.1","upper rhombic lip":"5.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":1,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA038387":null,"HPA038388":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.24e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - 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T-cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"C11orf71","Gene synonym":["FLJ20010"],"Ensembl":"ENSG00000180425","Gene description":"Chromosome 11 open reading frame 71","Uniprot":["Q6IPW1"],"Chromosome":"11","Position":"114391443-114400511","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"130.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"9403.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"76","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"9403.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA063943","HPA074787"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA063943":null,"HPA074787":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.38e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.90e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"}},{"Gene":"C11orf80","Gene synonym":["FLJ22531","TOPOVIBL"],"Ensembl":"ENSG00000173715","Gene description":"Chromosome 11 open reading frame 80","Uniprot":["Q8N6T0"],"Chromosome":"11","Position":"66744451-66843516","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"260.8","Renal collecting duct intercalated cells":"434.7","Renal collecting duct principal cells":"583.8","Renal connecting tubule cells":"463.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"583.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":null,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA038932":null,"HPA038933":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.02e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.52e-7"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"C11orf91","Gene synonym":[],"Ensembl":"ENSG00000205177","Gene description":"Chromosome 11 open reading frame 91","Uniprot":["Q3C1V1"],"Chromosome":"11","Position":"33698261-33700826","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"4.4","gallbladder":"4.3","testis":"9.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"10.2","Late primary spermatocytes":"25.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"28","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"25.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"2.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA047064":null,"HPA050487":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C11orf94","Gene synonym":["Frey"],"Ensembl":"ENSG00000234776","Gene description":"Chromosome 11 open reading frame 94","Uniprot":["C9JXX5"],"Chromosome":"11","Position":"45906513-45907272","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"158","RNA tissue specific nTPM":{"testis":"54.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"144","RNA single cell type specific nCPM":{"Early spermatids":"436.4","Late primary spermatocytes":"197.9","Late spermatids":"264.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"210","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"436.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-5"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C11orf97","Gene synonym":["LINC01171"],"Ensembl":"ENSG00000257057","Gene description":"Chromosome 11 open reading frame 97","Uniprot":["A0A1B0GVM6"],"Chromosome":"11","Position":"94512461-94532123","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"10.4","choroid plexus":"10.8","fallopian tube":"18.0","testis":"18.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"196.6","Endometrial ciliated cells":"255.6","Epididymal efferent duct ciliated cells":"322.3","Fallopian tube ciliated cells":"320.0","Late primary spermatocytes":"269.2","Respiratory ciliated cells":"381.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"49","RNA single cell type group specific nCPM":{"Ciliated cells":"381.0","Spermatogenic cell types":"269.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"30.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"18","RNA cell line specific nTPM":{"lymphoma":"1.7"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038359":null,"HPA058728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C13orf46","Gene synonym":[],"Ensembl":"ENSG00000283199","Gene description":"Chromosome 13 open reading frame 46","Uniprot":["A0A1B0GUA9"],"Chromosome":"13","Position":"113953705-113974076","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"8.7","stomach 1":"6.1","testis":"11.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"3.0","Early spermatids":"11.0","Ependymal cells":"2.3","Late primary spermatocytes":"4.6","Late spermatids":"24.5","Microglia":"2.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"24.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"4.4","leukocyte":"4.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA059635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"}},{"Gene":"C15orf39","Gene synonym":["DKFZP434H132","FLJ46337"],"Ensembl":"ENSG00000167173","Gene description":"Chromosome 15 open reading frame 39","Uniprot":["Q6ZRI6"],"Chromosome":"15","Position":"75195643-75212169","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"58.4","testis":"69.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"53.8","Esophageal apical cells":"49.8","Late primary spermatocytes":"87.7","Late spermatids":"144.8","Neutrophils":"118.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"118.7","Spermatogenic cell types":"144.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"13.4","pericyte":"13.6","vascular associated smooth muscle cell":"14.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"8.1","granulocytes":"23.6","monocytes":"16.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.42e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"}},{"Gene":"C15orf48","Gene synonym":["COXFA4L3","MIR147BHG","MISTRAV","MOCCI","NMES1"],"Ensembl":"ENSG00000166920","Gene description":"Chromosome 15 open reading frame 48","Uniprot":["Q9C002"],"Chromosome":"15","Position":"45430579-45448761","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"intestine":"866.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"769.7","Colonocytes":"3918.2","Enteric stem cells":"1312.7","Enteric transient amplifying cells":"2389.2","Enterocytes":"2603.8","Esophageal apical cells":"5880.7","Extravillous trophoblasts":"786.5","Goblet cells":"1329.8","Late primary spermatocytes":"1075.0","Pancreatic acinar cells":"1096.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"5880.7","Enterocytes":"3918.2","Proliferating cells":"2389.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"6.3"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"classical monocyte":"1.3","intermediate monocyte":"1.6","myeloid DC":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"606.0"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"5007916.6","Oocytes":"16643523.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"550263.2"},"Antibody":["HPA012943"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA012943":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"}},{"Gene":"C15orf61","Gene synonym":["LOC145853"],"Ensembl":"ENSG00000189227","Gene description":"Chromosome 15 open reading frame 61","Uniprot":["A6NNL5"],"Chromosome":"15","Position":"67521131-67530146","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"22.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"174.3","Late primary spermatocytes":"546.9","Oocytes":"414.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Oocytes":"414.5","Spermatogenic cell types":"546.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"6333","Protein cell type specific Intensity":{"Distal tubules":"633254.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA062820"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Vesicles","Cytosol"],"Secretome location":"Secreted - unknown location","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoli","Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA062820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"}},{"Gene":"C16orf46","Gene synonym":["FLJ32702"],"Ensembl":"ENSG00000166455","Gene description":"Chromosome 16 open reading frame 46","Uniprot":["Q6P387"],"Chromosome":"16","Position":"81053497-81077267","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"13.1","Epididymal efferent duct ciliated cells":"2.1","Fallopian tube ciliated cells":"3.3","Late primary spermatocytes":"4.0","Late spermatids":"14.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"14.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Pituitary gland - Somatotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041136","HPA041379"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA041136":null,"HPA041379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.86e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"C16orf86","Gene synonym":["FLJ41802"],"Ensembl":"ENSG00000159761","Gene description":"Chromosome 16 open reading frame 86","Uniprot":["Q6ZW13"],"Chromosome":"16","Position":"67666814-67668757","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"10.2","testis":"37.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"111.3","Late primary spermatocytes":"249.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"249.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"1.6","Myeloma":"1.7"},"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA073475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA041179":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.20e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"}},{"Gene":"C16orf90","Gene synonym":["LOC646174"],"Ensembl":"ENSG00000215131","Gene description":"Chromosome 16 open reading frame 90","Uniprot":["A8MZG2"],"Chromosome":"16","Position":"3493484-3495489","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"419","RNA tissue specific nTPM":{"testis":"46.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"34","RNA single cell type specific nCPM":{"Early spermatids":"260.4","Late primary spermatocytes":"195.0","Late spermatids":"779.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"198","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"779.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":null,"Antibody RRID":{"HPA042009":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C17orf100","Gene synonym":["LOC388327"],"Ensembl":"ENSG00000256806","Gene description":"Chromosome 17 open reading frame 100","Uniprot":["A8MU93"],"Chromosome":"17","Position":"6651762-6693202","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"16.5","Epididymal principal cells":"22.5","Late primary spermatocytes":"13.7","Late spermatids":"23.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"22.5","Spermatogenic cell types":"23.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":16,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA010974":null,"HPA012896":null,"HPA073479":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - 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Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2369","Protein cell type specific Intensity":{"Fallopian tube cells":"236924.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"13264","Protein tissue specific Intensity":{"fallopian tube":"1326399.9"},"Antibody":["HPA023583"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023583":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"}},{"Gene":"C17orf98","Gene synonym":["LOC388381"],"Ensembl":"ENSG00000275489","Gene description":"Chromosome 17 open reading frame 98","Uniprot":["A8MV24"],"Chromosome":"17","Position":"38835086-38841438","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"68","RNA tissue specific nTPM":{"testis":"18.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"228.2","Late primary spermatocytes":"168.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"110","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"228.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051696"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051696":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C18orf21","Gene synonym":["HsT3108","PNAS-124","PNAS-131"],"Ensembl":"ENSG00000141428","Gene description":"Chromosome 18 open reading frame 21","Uniprot":["Q32NC0"],"Chromosome":"18","Position":"35972625-35979286","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"116.2","Late primary spermatocytes":"270.7","Late spermatids":"84.9","Oocytes":"59.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"270.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"13","Protein tissue specific Intensity":{"lymphoid tissue":"1270.2"},"Antibody":["HPA065505","HPA067322"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":90,"Subcellular main location":["Nucleoli","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA065505":null,"HPA067322":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.49e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.81e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"}},{"Gene":"C18orf32","Gene synonym":["FLJ23458"],"Ensembl":"ENSG00000177576","Gene description":"Chromosome 18 open reading frame 32","Uniprot":["Q8TCD1"],"Chromosome":"18","Position":"49477243-49487252","Protein class":["Disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"258.2","Gastric chief cells":"139.8","Late spermatids":"250.6","Parietal cells":"312.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"312.9","Spermatogenic cell types":"258.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"261860.9"},"Antibody":["HPA040921"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA040921":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.38e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"}},{"Gene":"C18orf54","Gene synonym":["LAS2","MGC33382"],"Ensembl":"ENSG00000166845","Gene description":"Chromosome 18 open reading frame 54","Uniprot":["Q8IYD9"],"Chromosome":"18","Position":"54357906-54385218","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"16.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"47.7","Early spermatids":"111.9","Extravillous trophoblasts":"35.6","Late primary spermatocytes":"92.0","Late spermatids":"39.2","Megakaryocyte progenitors":"22.8","Megakaryocytes":"24.7","Oligodendrocytes":"18.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"111.9","Trophoblast cells":"35.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"26.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"1.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":8,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA077475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.69e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"}},{"Gene":"C19orf18","Gene synonym":["MGC41906"],"Ensembl":"ENSG00000177025","Gene description":"Chromosome 19 open reading frame 18","Uniprot":["Q8NEA5"],"Chromosome":"19","Position":"57958437-57974534","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"15.2","testis":"11.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"65.6","Early spermatids":"134.9","Ependymal cells":"49.0","Late primary spermatocytes":"122.3","Myonuclei":"47.1","Sertoli cells":"41.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"65.6","Myocytes":"47.1","Spermatogenic cell types":"134.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"41.2","choroid plexus epithelial cell":"46.5","ependymal cell":"49.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":3,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA014527":null,"HPA079195":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"}},{"Gene":"C19orf44","Gene synonym":["FLJ21742"],"Ensembl":"ENSG00000105072","Gene description":"Chromosome 19 open reading frame 44","Uniprot":["Q9H6X5"],"Chromosome":"19","Position":"16496394-16521352","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"59.6","Epicardial cells":"31.8","Late spermatids":"127.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"127.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"3.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1960","Protein cell type specific Intensity":{"Fallopian tube cells":"196040.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041683","HPA049414"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Golgi apparatus","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Golgi apparatus","Primary cilium","Cytosol"],"Antibody RRID":{"HPA041683":null,"HPA049414":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.11e-5"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"}},{"Gene":"C19orf47","Gene synonym":["FLJ36888"],"Ensembl":"ENSG00000160392","Gene description":"Chromosome 19 open reading frame 47","Uniprot":["Q8N9M1"],"Chromosome":"19","Position":"40319536-40348527","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"heart muscle":"164.2","skeletal muscle":"335.4","tongue":"128.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"37.0","Late spermatids":"43.7","Thymic myoid cells":"116.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"43.7","Stromal cells":"116.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"29.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"29.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"600202.9","Hepatocytes":"785545.0","Neurons":"502535.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"507","Protein tissue specific Intensity":{"lymphoid tissue":"50701.7"},"Antibody":["HPA041843","HPA046309"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear speckles"],"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"HPA041843":null,"HPA046309":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"}},{"Gene":"C19orf67","Gene synonym":[],"Ensembl":"ENSG00000188032","Gene description":"Chromosome 19 open reading frame 67","Uniprot":["A6NJJ6"],"Chromosome":"19","Position":"14081624-14085875","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"testis":"6.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"30","RNA single cell type specific nCPM":{"Early spermatids":"8.0","Late primary spermatocytes":"9.6","Late spermatids":"9.3","Oocytes":"4.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Oocytes":"4.6","Spermatogenic cell types":"9.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046351"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA046351":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C1GALT1C1L","Gene synonym":[],"Ensembl":"ENSG00000223658","Gene description":"C1GALT1 specific chaperone 1 like","Uniprot":["P0DN25"],"Chromosome":"2","Position":"43675151-43676429","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"19.3","Early primary spermatocytes":"12.6","Endometrial stromal cells":"5.4","Epididymal principal cells":"6.0","Late primary spermatocytes":"17.2","Retinal pigment epithelial cells":"4.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"17.2","Stromal cells":"19.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"2.5","committed oligodendrocyte precursor":"2.4","oligodendrocyte":"2.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":6,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA079382":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C1orf116","Gene synonym":["FLJ36507","MGC2742","MGC4309","SARG"],"Ensembl":"ENSG00000182795","Gene description":"Chromosome 1 open reading frame 116","Uniprot":["Q9BW04"],"Chromosome":"1","Position":"207018522-207032756","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"98.1","lung":"68.8","stomach 1":"55.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"244.4","Esophageal apical cells":"748.6","Esophageal suprabasal cells":"127.9","Foveolar cells":"126.2","Ocular epithelial cells":"379.8","Transitional alveolar cells":"137.1","Urothelial cells":"220.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"244.4","Apical squamous epithelial cells":"748.6","Barrier epithelial cells":"379.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"118.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"57.3"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"62000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":4,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA011888":null,"HPA011889":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"C1orf141","Gene synonym":[],"Ensembl":"ENSG00000203963","Gene description":"Chromosome 1 open reading frame 141","Uniprot":["Q5JVX7"],"Chromosome":"1","Position":"67092165-67231853","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"8.7","testis":"14.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"107.1","Ependymal cells":"51.4","Fallopian tube ciliated cells":"96.0","Granulosa cells":"87.6","Innate lymphoid cells":"32.6","Late primary spermatocytes":"110.6","Late spermatids":"134.7","M\u00fcller glia":"56.6","Respiratory ciliated cells":"85.1","Sertoli cells":"87.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"96.0","Glial cells":"56.6","Reproductive supporting cells":"87.6","Spermatogenic cell types":"134.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"ependymal cell":"58.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"5.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":null,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA035316":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C1orf159","Gene synonym":["FLJ20584"],"Ensembl":"ENSG00000131591","Gene description":"Chromosome 1 open reading frame 159","Uniprot":["Q96HA4"],"Chromosome":"1","Position":"1081818-1116361","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"22.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"228.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"228.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoli rim","Mitotic chromosome"],"Subcellular additional location":["Intermediate filaments"],"Antibody RRID":{"HPA010019":null,"HPA075399":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":71,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA028299":null,"HPA031343":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.55e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"C1orf50","Gene synonym":["MGC955"],"Ensembl":"ENSG00000164008","Gene description":"Chromosome 1 open reading frame 50","Uniprot":["Q9BV19"],"Chromosome":"1","Position":"42767245-42779491","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"1.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"1717130.2","Oocytes":"6202827.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030236"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030236":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.59e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"C1orf56","Gene synonym":["FLJ20519","MENT"],"Ensembl":"ENSG00000143443","Gene description":"Chromosome 1 open reading frame 56","Uniprot":["Q9BUN1"],"Chromosome":"1","Position":"151047751-151051986","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"71.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"412.2","Late primary spermatocytes":"751.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"751.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037429","HPA037430"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8100000","Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037429":null,"HPA037430":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"C1orf87","Gene synonym":["CREF","MGC34837"],"Ensembl":"ENSG00000162598","Gene description":"Chromosome 1 open reading frame 87","Uniprot":["Q8N0U7"],"Chromosome":"1","Position":"59987269-60073770","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"28.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"77.4","Endometrial ciliated cells":"115.8","Ependymal cells":"262.8","Epididymal efferent duct ciliated cells":"95.3","Fallopian tube ciliated cells":"184.8","Late primary spermatocytes":"135.1","Respiratory ciliated cells":"303.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Ciliated cells":"303.9","Spermatogenic cell types":"135.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"ependymal cell":"315.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"1.2","Uterine Corpus Endometrial Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"347097","Protein cell type specific Intensity":{"Fallopian tube cells":"34709696.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"251241","Protein tissue specific Intensity":{"fallopian tube":"25124052.4"},"Antibody":["HPA031366","HPA031368"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":89,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA045805":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":7,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":null,"Antibody RRID":{"HPA048649":null,"HPA056227":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.87e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.85e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"}},{"Gene":"C21orf58","Gene synonym":[],"Ensembl":"ENSG00000160298","Gene description":"Chromosome 21 open reading frame 58","Uniprot":["P58505"],"Chromosome":"21","Position":"46300181-46323875","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"24.9","pituitary gland":"20.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"104.3","Endometrial ciliated cells":"157.9","Ependymal cells":"74.7","Epididymal efferent duct ciliated cells":"139.8","Erythrocyte progenitors":"115.2","Fallopian tube ciliated cells":"192.4","Platelets":"91.9","Respiratory ciliated cells":"231.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"231.0","Erythrocytes":"115.2","Spermatogenic cell types":"104.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"75.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"4.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"4.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Primary cilium transition zone"],"Antibody RRID":{"HPA035110":null,"HPA035111":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.15e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.32e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"}},{"Gene":"C22orf15","Gene synonym":["FLJ36561","N27C7-3"],"Ensembl":"ENSG00000169314","Gene description":"Chromosome 22 open reading frame 15","Uniprot":["Q8WYQ4"],"Chromosome":"22","Position":"23762990-23765863","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"fallopian tube":"17.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"22.6","Ependymal cells":"35.7","Epididymal efferent duct ciliated cells":"30.2","Fallopian tube ciliated cells":"90.4","Late primary spermatocytes":"16.0","Respiratory ciliated cells":"114.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"114.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"68","RNA single nuclei brain specific nCPM":{"ependymal cell":"42.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.1"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Endoplasmic reticulum","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA019494":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - 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Respiratory ciliated cells","Prostate - Smooth muscle cells","Stomach - Parietal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"323","Protein tissue specific Intensity":{"salivary gland":"32266.1"},"Antibody":["HPA000650"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000650":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"}},{"Gene":"C22orf31","Gene synonym":["bK747E2.1","HS747E2A"],"Ensembl":"ENSG00000100249","Gene description":"Chromosome 22 open reading frame 31","Uniprot":["O95567"],"Chromosome":"22","Position":"29058672-29061831","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"2.6","parathyroid gland":"2.9","testis":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"111.2","Granulosa cells":"11.4","Late primary spermatocytes":"23.7","Late spermatids":"59.7","Retinal pigment epithelial cells":"8.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"111.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"1.6","Bergmann glia":"1.8","fibroblast":"1.9","medium spiny neuron":"1.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"cervical cancer":"1.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA000604":null,"HPA068522":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C22orf42","Gene synonym":[],"Ensembl":"ENSG00000205856","Gene description":"Chromosome 22 open reading frame 42","Uniprot":["Q6IC83"],"Chromosome":"22","Position":"32149006-32159322","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"brain":"9.4","testis":"10.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"126.5","Late primary spermatocytes":"41.7","Late spermatids":"46.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"126.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"amygdala excitatory":"1.7","splatter":"2.7","thalamic excitatory":"3.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"1.4","Prostate Adenocarcinoma (TCGA)":"1.5"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"hypothalamus":"23.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Pancreas - Beta cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019531"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C2CD3","Gene synonym":["DKFZP586P0123"],"Ensembl":"ENSG00000168014","Gene description":"C2 domain containing 3 centriole elongation regulator","Uniprot":["Q4AC94"],"Chromosome":"11","Position":"74012718-74171210","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"122.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"21.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":3,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body"],"Subcellular additional location":["Acrosome","Equatorial segment","Principal piece"],"Antibody RRID":{"HPA038552":null,"HPA038553":null,"HPA040433":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.87e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"C2CD6","Gene synonym":["ALS2CR11","FLJ25351"],"Ensembl":"ENSG00000155754","Gene description":"C2 calcium dependent domain containing 6","Uniprot":["Q53TS8"],"Chromosome":"2","Position":"201487421-201619178","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"30","RNA tissue specific nTPM":{"testis":"37.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"104.2","Choroid plexus epithelial cells":"73.3","Early spermatids":"267.9","Late primary spermatocytes":"399.1","Late spermatids":"289.6","Rod photoreceptor cells":"78.2","Somatotrophs":"155.5","Thyrotrophs":"87.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"104.2","Pituitary endocrine cells":"155.5","Spermatogenic cell types":"399.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"96.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"3.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Adrenocortical cancer":"7.8"},"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":44,"Subcellular main location":["Principal piece"],"Subcellular additional location":["Acrosome","Equatorial segment"],"Antibody RRID":{"HPA045406":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA031840":null,"HPA031841":null,"HPA031842":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020869":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA055221":null,"HPA059596":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"}},{"Gene":"C2orf74","Gene synonym":["LOC339804"],"Ensembl":"ENSG00000237651","Gene description":"Chromosome 2 open reading frame 74","Uniprot":["A8MZ97"],"Chromosome":"2","Position":"61145068-61164828","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"16.6","Bergmann glia":"16.5","Brain excitatory neurons":"20.8","Brain inhibitory neurons":"20.0","Early spermatids":"19.6","Ependymal cells":"16.5","Epididymal principal cells":"14.0","Loop of henle epithelial cells":"16.5","Microglia":"18.1","Oligodendrocytes":"19.7","Other brain neurons":"25.5","Papillary tip epithelial cells":"13.7","Podocytes":"13.4","Proximal tubule cells":"17.6","Renal collecting duct principal cells":"12.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"16.5","Glial cells":"19.7","Neuronal cells":"25.5","Renal nephron cells":"17.6","Spermatogenic cell types":"19.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":1,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA026826":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"}},{"Gene":"C2orf76","Gene synonym":["AIM29","LOC130355","MGC104437"],"Ensembl":"ENSG00000186132","Gene description":"Chromosome 2 open reading frame 76","Uniprot":["Q3KRA6"],"Chromosome":"2","Position":"119302225-119366834","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oocytes":"175.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"175.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"46","Protein cell type specific Intensity":{"Collecting ducts":"2504.4","Oocytes":"3107.4","Pancreas epithelial cells":"8212.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"2514395.1"},"Antibody":["HPA044977","HPA055362"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA044977":null,"HPA055362":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.34e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.21e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"}},{"Gene":"C2orf81","Gene synonym":["hCG40743","LOC388963"],"Ensembl":"ENSG00000284308","Gene description":"Chromosome 2 open reading frame 81","Uniprot":["A6NN90"],"Chromosome":"2","Position":"74414176-74421619","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"18.1","testis":"17.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Ependymal cells":"96.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"96.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"114.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"13.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7529","Protein cell type specific Intensity":{"Fallopian tube cells":"752862.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"8757","Protein tissue specific Intensity":{"fallopian tube":"875725.0"},"Antibody":["HPA049564","HPA054835"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Nucleoli","Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA049564":null,"HPA054835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"}},{"Gene":"C2orf88","Gene synonym":["MGC13057","smAKAP"],"Ensembl":"ENSG00000187699","Gene description":"Chromosome 2 open reading frame 88","Uniprot":["Q9BSF0"],"Chromosome":"2","Position":"189879609-190203484","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"68.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"361.4","Early spermatids":"1540.4","Endometrial luminal cells":"327.4","Enterocytes":"442.7","Epicardial cells":"382.1","Late spermatids":"1845.1","Megakaryocytes":"537.8","Platelets":"1847.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"1847.3","Spermatogenic cell types":"1845.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"35.5","Uterine Corpus Endometrial Carcinoma (TCGA)":"47.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"2.7","naive B-cell":"2.9","neutrophil":"7.3","plasmacytoid DC":"3.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"B-cells":"2.9","dendritic cells":"3.0","granulocytes":"7.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Colon - Enteric glia cells","Liver - Sinusoid Endothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"187216.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"17819397.4"},"Antibody":["HPA049549"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"62000","Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049549":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.83e-6"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-5"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"}},{"Gene":"C2orf92","Gene synonym":["LINC01125"],"Ensembl":"ENSG00000228486","Gene description":"Chromosome 2 open reading frame 92","Uniprot":["A0A1B0GVN3"],"Chromosome":"2","Position":"97664217-97703066","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"13.3","testis":"11.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"247.1","Late primary spermatocytes":"171.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"247.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C3orf14","Gene synonym":["HT021"],"Ensembl":"ENSG00000114405","Gene description":"Chromosome 3 open reading frame 14","Uniprot":["Q9HBI5"],"Chromosome":"3","Position":"62319015-62336213","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"59.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"122.0","Early primary spermatocytes":"158.5","Early spermatids":"129.8","Late primary spermatocytes":"196.3","Oocytes":"96.7","Pancreatic islet cells":"98.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Luminal cells":"122.0","Spermatogenic cell types":"196.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"28.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":8,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA048286":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.70e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"}},{"Gene":"C3orf20","Gene synonym":["DKFZP434N1817"],"Ensembl":"ENSG00000131379","Gene description":"Chromosome 3 open reading frame 20","Uniprot":["Q8ND61"],"Chromosome":"3","Position":"14675141-14773036","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"testis":"6.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"28.1","Late primary spermatocytes":"22.9","Late spermatids":"64.6","Neutrophils":"30.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"30.1","Spermatogenic cell types":"64.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"1.7"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039584":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C3orf38","Gene synonym":["MGC26717"],"Ensembl":"ENSG00000179021","Gene description":"Chromosome 3 open reading frame 38","Uniprot":["Q5JPI3"],"Chromosome":"3","Position":"88149959-88168729","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"306.6","Late primary spermatocytes":"289.1","Late spermatids":"500.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"500.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA034736":null,"HPA034737":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.87e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - 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Mesothelial cells","Breast - Breast glandular cells","Liver - Cholangiocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008119","HPA011968"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":104,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA008119":null,"HPA011968":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.87e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-3"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"}},{"Gene":"C3orf62","Gene synonym":["FLJ43654","MAPS"],"Ensembl":"ENSG00000188315","Gene description":"Chromosome 3 open reading frame 62","Uniprot":["Q6ZUJ4"],"Chromosome":"3","Position":"49268596-49277232","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"48.2","Late primary spermatocytes":"97.1","Neutrophils":"141.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"141.5","Spermatogenic cell types":"97.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"neutrophil":"40.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"40.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043328","CAB080594"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":14,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB080594":null,"HPA043328":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.27e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"}},{"Gene":"C3orf80","Gene synonym":[],"Ensembl":"ENSG00000180044","Gene description":"Chromosome 3 open reading frame 80","Uniprot":["F5H4A9"],"Chromosome":"3","Position":"160225422-160228213","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"12.5","esophagus":"4.3","intestine":"7.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"8.6","Esophageal apical cells":"46.1","Hematopoietic stem cells":"29.6","Late primary spermatocytes":"9.5","Megakaryocyte progenitors":"9.3","Megakaryocyte-Erythroid progenitors":"8.2","Megakaryocytes":"30.9","Neuroendocrine cells":"7.4","Parietal cells":"8.8","Retinal horizontal cells":"6.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"46.1","Megakaryocytes":"30.9","Stem cells":"29.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"8.6"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047439":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":265000000000,"Blood concentration - Conc. blood MS [pg\/L]":"1900000000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 53: Liver - Plasma proteins","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA000925":null,"HPA051620":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA047287":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.51e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.72e-4"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.12e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"}},{"Gene":"C4orf51","Gene synonym":[],"Ensembl":"ENSG00000237136","Gene description":"Chromosome 4 open reading frame 51","Uniprot":["C9J302"],"Chromosome":"4","Position":"145680146-145771032","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"71.4","Early spermatids":"109.1","Epicardial cells":"34.1","Late primary spermatocytes":"80.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"34.1","Myocytes":"71.4","Spermatogenic cell types":"109.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"1.3","Testicular Germ Cell Tumor (TCGA)":"2.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C5AR2","Gene synonym":["C5L2","GPR77"],"Ensembl":"ENSG00000134830","Gene description":"Complement C5a receptor 2","Uniprot":["Q9P296"],"Chromosome":"19","Position":"47332175-47347329","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"13.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"35.4","Kupffer cells":"149.6","Macrophages":"84.4","monocytes":"139.2","Neutrophil progenitors":"56.3","Neutrophils":"240.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"149.6","Neutrophils":"240.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"20.0","deep-layer corticothalamic and 6b":"13.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"17.8","eosinophil":"11.9","neutrophil":"33.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"33.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"5.6","Leukemia":"3.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"}},{"Gene":"C5orf47","Gene synonym":["LOC133491"],"Ensembl":"ENSG00000185056","Gene description":"Chromosome 5 open reading frame 47","Uniprot":["Q569G3"],"Chromosome":"5","Position":"173973779-174006140","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"98","RNA tissue specific nTPM":{"testis":"20.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"102.2","Early primary spermatocytes":"574.9","Early spermatids":"99.9","Late primary spermatocytes":"214.0","Undifferentiated spermatogonia":"37.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"574.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C5orf49","Gene synonym":["LOC134121"],"Ensembl":"ENSG00000215217","Gene description":"Chromosome 5 open reading frame 49","Uniprot":["A4QMS7"],"Chromosome":"5","Position":"7830378-7851151","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"21.2","choroid plexus":"70.4","fallopian tube":"71.2","testis":"36.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"797.7","Endometrial ciliated cells":"373.2","Epididymal efferent duct ciliated cells":"515.0","Fallopian tube ciliated cells":"938.4","Late primary spermatocytes":"470.8","Late spermatids":"527.2","Respiratory ciliated cells":"770.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"46","RNA single cell type group specific nCPM":{"Ciliated cells":"938.4","Spermatogenic cell types":"797.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"214.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"21.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"1.8"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Kidney - Proximal tubular cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"18025","Protein cell type specific Intensity":{"Fallopian tube cells":"1802499.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"21952","Protein tissue specific Intensity":{"fallopian tube":"2195233.9"},"Antibody":["HPA043759"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043759":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.51e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.74e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.50e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"}},{"Gene":"C5orf58","Gene synonym":[],"Ensembl":"ENSG00000234511","Gene description":"Chromosome 5 open reading frame 58","Uniprot":["C9J3I9"],"Chromosome":"5","Position":"170229104-170252575","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"31","RNA tissue specific nTPM":{"testis":"201.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early primary spermatocytes":"1120.6","Late primary spermatocytes":"1046.9","Oocytes":"308.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"36","RNA single cell type group specific nCPM":{"Oocytes":"308.5","Spermatogenic cell types":"1120.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"2.7","fibroblast":"2.7","leukocyte":"2.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"9.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"8.1"},"RNA tissue cell type enrichment":["Kidney - T-cells","Lung - NK-cells (Lung)","Minor Salivary Gland - Macrophages","Stomach - Fibroblasts","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052795"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytokinetic bridge","Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":["Cytokinetic bridge","Cytosol"],"Antibody RRID":{"HPA052795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"C6orf118","Gene synonym":["bA85G2.1","MGC23884"],"Ensembl":"ENSG00000112539","Gene description":"Chromosome 6 open reading frame 118","Uniprot":["Q5T5N4"],"Chromosome":"6","Position":"165279664-165309605","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"9.4","fallopian tube":"15.4","testis":"6.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"130.9","Early spermatids":"120.2","Endometrial ciliated cells":"195.1","Ependymal cells":"333.5","Epididymal efferent duct ciliated cells":"237.1","Fallopian tube ciliated cells":"313.9","Late primary spermatocytes":"119.0","Late spermatids":"80.6","Respiratory ciliated cells":"333.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"333.5","Spermatogenic cell types":"120.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"135.4","ependymal cell":"360.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.5"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"62.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Pituitary gland - Somatotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"25829","Protein cell type specific Intensity":{"Fallopian tube cells":"2582923.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029787","HPA029789"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA029787":null,"HPA029789":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"}},{"Gene":"C6orf120","Gene synonym":["bA160E12.4"],"Ensembl":"ENSG00000185127","Gene description":"Chromosome 6 open reading frame 120","Uniprot":["Q7Z4R8"],"Chromosome":"6","Position":"169702126-169706360","Protein class":["Predicted secreted proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"123.6","Epicardial cells":"104.6","Late primary spermatocytes":"81.2","Late spermatids":"464.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"464.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"960000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039626":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.64e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.71e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.20e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.04e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"}},{"Gene":"C6orf163","Gene synonym":[],"Ensembl":"ENSG00000203872","Gene description":"Chromosome 6 open reading frame 163","Uniprot":["Q5TEZ5"],"Chromosome":"6","Position":"87344813-87365463","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"7.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"13","RNA single cell type specific nCPM":{"Early spermatids":"16.3","Late spermatids":"15.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"16.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"basal ganglia":"1.5"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044797","HPA052927"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044797":null,"HPA052927":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C6orf52","Gene synonym":[],"Ensembl":"ENSG00000137434","Gene description":"Chromosome 6 open reading frame 52","Uniprot":["Q5T4I8"],"Chromosome":"6","Position":"10671418-10694797","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"13.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Oocytes":"1243.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Oocytes":"1243.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"23.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"eosinophil":"2.7","T-reg":"4.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"2.7","T-cells":"4.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4209","Protein cell type specific Intensity":{"Oocytes":"420856.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051142"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Intermediate filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Intermediate filaments"],"Antibody RRID":{"HPA051142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"C6orf58","Gene synonym":["LEG1"],"Ensembl":"ENSG00000184530","Gene description":"Chromosome 6 open reading frame 58","Uniprot":["Q6P5S2"],"Chromosome":"6","Position":"127519455-127591820","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"salivary gland":"2318.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric chief cells":"83.0","Mucous neck cells":"425.5","Neuroendocrine cells":"24.5","Submucosal glandular cells":"159.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Gastric glandular cells":"425.5","Glandular cells":"159.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"12.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"40.6","Stomach Adenocarcinoma (TCGA)":"27.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Kidney cancer":"2.3","lymphoma":"3.3"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"8234","Protein cell type specific Intensity":{"Large ducts":"823421.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"200977509.1","salivary gland":"60019324.4"},"Antibody":["HPA036263","HPA041449"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":"Secreted to digestive system","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"33000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":9,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA036263":null,"HPA041449":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C7orf31","Gene synonym":[],"Ensembl":"ENSG00000153790","Gene description":"Chromosome 7 open reading frame 31","Uniprot":["Q8N865"],"Chromosome":"7","Position":"25134692-25180356","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"61.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"539.3","Late spermatids":"1448.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1448.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"25.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":15,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020346":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.02e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.17e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.20e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.45e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Primary cilium","Primary cilium transition zone","Basal body"],"Antibody RRID":{"HPA021286":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.81e-4"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"}},{"Gene":"C8G","Gene synonym":[],"Ensembl":"ENSG00000176919","Gene description":"Complement C8 gamma chain","Uniprot":["P07360"],"Chromosome":"9","Position":"136945185-136946975","Protein class":["Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Complement alternate pathway","Complement pathway","Cytolysis","Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"liver":"522.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Hepatocytes":"1125.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Hepatocytes":"1125.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"61","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"321.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Gastric cancer":"6.2","liver cancer":"2.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5500000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046269":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C8orf48","Gene synonym":["FLJ25402"],"Ensembl":"ENSG00000164743","Gene description":"Chromosome 8 open reading frame 48","Uniprot":["Q96LL4"],"Chromosome":"8","Position":"13566869-13568288","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"6.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"29.3","Late primary spermatocytes":"47.5","Late spermatids":"88.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"88.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"10.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"4.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":17,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA026107":null,"HPA027440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C8orf58","Gene synonym":["FLJ34715"],"Ensembl":"ENSG00000241852","Gene description":"Chromosome 8 open reading frame 58","Uniprot":["Q8NAV2"],"Chromosome":"8","Position":"22599599-22604150","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"16.4","Cytotrophoblasts":"28.3","Decidual stromal cells":"18.8","Extravillous trophoblasts":"41.1","Migrating cytotrophoblasts":"43.9","Podocytes":"25.6","Syncytiotrophoblasts":"62.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"25.6","Trophoblast cells":"62.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"9.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":null,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA024667":null,"HPA028286":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.72e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA078486":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.41e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"}},{"Gene":"C8orf89","Gene synonym":[],"Ensembl":"ENSG00000274443","Gene description":"Chromosome 8 open reading frame 89","Uniprot":["P0DMQ9"],"Chromosome":"8","Position":"73241331-73259530","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"7.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late primary spermatocytes":"62.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"62.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"memory B-cell":"2.7","naive B-cell":"4.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"4.8"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C9orf131","Gene synonym":["MGC41945"],"Ensembl":"ENSG00000174038","Gene description":"Chromosome 9 open reading frame 131","Uniprot":["Q5VYM1"],"Chromosome":"9","Position":"35041095-35045986","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"33.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"30.2","Early spermatids":"128.6","Epicardial cells":"109.2","Late primary spermatocytes":"73.7","Late spermatids":"47.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"109.2","Myocytes":"30.2","Spermatogenic cell types":"128.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"4.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"6.6"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA022029"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA022029":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"}},{"Gene":"C9orf153","Gene synonym":["bA507D14.1"],"Ensembl":"ENSG00000187753","Gene description":"Chromosome 9 open reading frame 153","Uniprot":["Q5TBE3"],"Chromosome":"9","Position":"86220265-86259657","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"19.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"679.5","Late primary spermatocytes":"261.2","Late spermatids":"503.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"679.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"40.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"classical monocyte":"1.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA079466"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nuclear bodies","Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA079466":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"}},{"Gene":"C9orf40","Gene synonym":["FLJ10110"],"Ensembl":"ENSG00000135045","Gene description":"Chromosome 9 open reading frame 40","Uniprot":["Q8IXQ3"],"Chromosome":"9","Position":"74946583-74952912","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"31.6","Erythrocyte progenitors":"75.4","Late primary spermatocytes":"36.7","Migrating cytotrophoblasts":"29.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"75.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"33.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"2.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"6111","Protein cell type specific Intensity":{"Oocytes":"611115.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042167"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"69000","Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA042167":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.74e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.39e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.30e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"}},{"Gene":"C9orf43","Gene synonym":["MGC17358"],"Ensembl":"ENSG00000157653","Gene description":"Chromosome 9 open reading frame 43","Uniprot":["Q8TAL5"],"Chromosome":"9","Position":"113410054-113429690","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"testis":"44.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"61.8","Early spermatids":"101.2","Epicardial cells":"43.2","Late primary spermatocytes":"168.6","Late spermatids":"364.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"364.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"10.7","ependymal cell":"14.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021310":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"C9orf57","Gene synonym":[],"Ensembl":"ENSG00000204669","Gene description":"Chromosome 9 open reading frame 57","Uniprot":["Q5W0N0"],"Chromosome":"9","Position":"72051376-72072721","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"87","RNA tissue specific nTPM":{"testis":"11.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"6.9","Early primary spermatocytes":"7.6","Late primary spermatocytes":"39.1","Tuft cells":"11.5","Undifferentiated spermatogonia":"4.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Secretory gland support":"11.5","Spermatogenic cell types":"39.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":21,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA021216":null,"HPA021232":null,"HPA021242":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.56e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.57e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.32e-4"}},{"Gene":"CA10","Gene synonym":["CA-RPX","CARPX","HUCEP-15"],"Ensembl":"ENSG00000154975","Gene description":"Carbonic anhydrase 10","Uniprot":["Q9NS85"],"Chromosome":"17","Position":"51630313-52160017","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"120.4","retina":"41.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"744.3","Distal convoluted tubule cells":"406.8","Oligodendrocyte progenitor cells":"1923.7","Oocytes":"658.5","Pituitary stem cells":"301.7","Podocytes":"1028.5","Retinal bipolar cells":"3104.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1923.7","Neuronal cells":"3104.1","Oocytes":"658.5","Renal nephron cells":"1028.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"2453.6","upper rhombic lip":"1773.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.4","Kidney Chromophobe (TCGA)":"10.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.3","thyroid cancer":"4.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":14,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA054825":null,"HPA057837":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"24000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025181":null,"CAB062549":null,"CAB068179":null,"HPA008773":null,"HPA073203":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.36e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"CA3","Gene synonym":["CAIII","Car3"],"Ensembl":"ENSG00000164879","Gene description":"Carbonic anhydrase 3","Uniprot":["P07451"],"Chromosome":"8","Position":"85373436-85449040","Protein class":["Enzymes","FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Lyase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skeletal muscle":"4941.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Myonuclei":"590.4","Thymic myoid cells":"908.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Myocytes":"590.4","Stromal cells":"908.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"230.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"53.6","Prostate Adenocarcinoma (TCGA)":"17.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Kidney cancer":"6.7","Sarcoma":"6.5"},"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"30000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB004967":null,"HPA021775":null,"HPA026700":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.01e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.89e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.08e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAB39L","Gene synonym":["bA103J18.3","FLJ12577","MO2L"],"Ensembl":"ENSG00000102547","Gene description":"Calcium binding protein 39 like","Uniprot":["Q9H9S4"],"Chromosome":"13","Position":"49308650-49444064","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"88.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"585.3","Early spermatids":"299.3","Fibro-adipogenic progenitors":"206.5","Late primary spermatocytes":"211.1","Prostatic glandular cells":"296.6","Schwann cells":"297.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"585.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"466.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"60.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"33.2"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":6,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB003686":null,"HPA045954":null,"HPA076632":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.75e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"}},{"Gene":"CABCOCO1","Gene synonym":["bA63A2.1","C10orf107","Em:AC022398.2","MGC44593"],"Ensembl":"ENSG00000183346","Gene description":"Ciliary associated calcium binding coiled-coil 1","Uniprot":["Q8IVU9"],"Chromosome":"10","Position":"61662929-61766766","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.6","fallopian tube":"25.1","testis":"14.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"118.6","Ependymal cells":"398.7","Epididymal efferent duct ciliated cells":"299.2","Fallopian tube ciliated cells":"322.3","Late primary spermatocytes":"159.4","Respiratory ciliated cells":"486.0","Thyrotrophs":"81.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"486.0","Spermatogenic cell types":"159.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"445.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":20,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA041398":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"}},{"Gene":"CABLES2","Gene synonym":["C20orf150","dJ908M14.2","ik3-2"],"Ensembl":"ENSG00000149679","Gene description":"Cdk5 and Abl enzyme substrate 2","Uniprot":["Q9BTV7"],"Chromosome":"20","Position":"62388634-62407285","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":["Cyclin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"29.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"32.7","Late primary spermatocytes":"59.1","Late spermatids":"38.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"59.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":2,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA043597":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.46e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.63e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"}},{"Gene":"CABYR","Gene synonym":["CBP86","CT88","FSP-2"],"Ensembl":"ENSG00000154040","Gene description":"Calcium binding tyrosine phosphorylation regulated","Uniprot":["O75952"],"Chromosome":"18","Position":"24138987-24161600","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"testis":"287.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"2840.6","Late spermatids":"5981.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5981.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"34.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"5.6","memory B-cell":"4.8","naive B-cell":"5.4","neutrophil":"2.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"5.4","granulocytes":"5.6"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Gallbladder cancer":"102.6"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":["Nucleoplasm","Cytosol","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA040703":null,"HPA047801":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.26e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"}},{"Gene":"CACNA1A","Gene synonym":["APCA","CACNL1A4","Cav2.1","EA2","FHM","HPCA","MHP","MHP1","SCA6"],"Ensembl":"ENSG00000141837","Gene description":"Calcium voltage-gated channel subunit alpha1 A","Uniprot":["O00555"],"Chromosome":"19","Position":"13206442-13633025","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calcium channel","Ion channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"43","RNA tissue specific nTPM":{"brain":"286.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"457.4","Brain excitatory neurons":"662.9","Brain inhibitory neurons":"570.0","Neuroendocrine cells":"1660.7","Oligodendrocyte progenitor cells":"736.9","Other brain neurons":"289.5","Pancreatic islet cells":"858.9","Pituitary stem cells":"619.2","Retinal amacrine cells":"1020.0","Retinal ganglion cells":"544.7","Retinal horizontal cells":"1336.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enteroendocrine cells":"1660.7","Glial cells":"736.9","Neuronal cells":"1336.3","Pancreatic islet cells":"858.9","Stem cells":"619.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"6.5"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"218.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"5.2","lung cancer":"8.4","Rhabdoid":"8.2"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Skeletal muscle - Smooth muscle cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Thyroid gland - Smooth muscle cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2389161.1","Microglia and Neuropil":"4789965.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"16417968.1"},"Antibody":["HPA064258","HPA068138","HPA071902"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Uncertain","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":41,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA064258":null,"HPA068138":null,"HPA071902":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.58e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.21e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"}},{"Gene":"CACNA1C","Gene synonym":["CACH2","CACN2","CACNL1A1","Cav1.2","CCHL1A1","LQT8","TS"],"Ensembl":"ENSG00000151067","Gene description":"Calcium voltage-gated channel subunit alpha1 C","Uniprot":["Q13936"],"Chromosome":"12","Position":"1970772-2697950","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Host-virus interaction","Ion transport","Transport"],"Molecular function":["Calcium channel","Calmodulin-binding","Ion channel","Voltage-gated channel"],"Disease involvement":["Autism","Autism spectrum disorder","Brugada syndrome","Disease variant","Epilepsy","FDA approved drug targets","Intellectual disability","Long QT syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"25.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"180.2","Bergmann glia":"163.4","Brain excitatory neurons":"661.1","Brain inhibitory neurons":"711.5","Choroid plexus epithelial cells":"147.0","Oligodendrocyte progenitor cells":"284.3","Other brain neurons":"504.7","Pericytes":"220.8","Vascular smooth muscle cells":"464.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"284.3","Mural cells":"464.1","Neuronal cells":"711.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"3.9"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Smooth muscle cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"16658493.6","Cardiomyocytes":"12731246.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2430111.7"},"Antibody":["HPA039796","CAB079031"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":27,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"CAB079031":null,"HPA039796":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.50e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CACNA1S","Gene synonym":["CACNL1A3","Cav1.1","HOKPP","hypoPP","MHS5"],"Ensembl":"ENSG00000081248","Gene description":"Calcium voltage-gated channel subunit alpha1 S","Uniprot":["Q13698"],"Chromosome":"1","Position":"201039512-201112451","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calcium channel","Calmodulin-binding","Ion channel","Voltage-gated channel"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"85","RNA tissue specific nTPM":{"skeletal muscle":"238.7","tongue":"180.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Myonuclei":"437.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Myocytes":"437.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"5.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"1.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"1.1"},"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"1.8"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"5","RNA pig brain regional specific nTPM":{"olfactory bulb":"3.8"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"346211","Protein cell type specific Intensity":{"Skeletal myofibers":"34621050.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"20049","Protein tissue specific Intensity":{"skeletal muscle":"2004892.1"},"Antibody":["CAB009507","HPA048892","HPA056815"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Acrosome","Equatorial segment"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":4,"Subcellular main location":["Acrosome","Equatorial segment"],"Subcellular additional location":null,"Antibody RRID":{"CAB009507":null,"HPA048892":null,"HPA056815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CACNA2D3","Gene synonym":["alpha2delta-3","HSA272268"],"Ensembl":"ENSG00000157445","Gene description":"Calcium voltage-gated channel auxiliary subunit alpha2delta 3","Uniprot":["Q8IZS8"],"Chromosome":"3","Position":"54122547-55074557","Protein class":["FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calcium channel","Ion channel","Voltage-gated channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"16.4","skeletal muscle":"9.3","tongue":"10.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"989.2","Brain excitatory neurons":"514.4","Brain inhibitory neurons":"1245.3","Corticotrophs":"724.3","Distal convoluted tubule cells":"1105.1","Epicardial cells":"502.6","Loop of henle epithelial cells":"1054.9","Myonuclei":"1035.9","Oligodendrocyte progenitor cells":"454.0","Pituicytes\/FSCs":"808.5","Pituitary stem cells":"657.7","Retinal ganglion cells":"544.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"989.2","Glial cells":"808.5","Myocytes":"1035.9","Neuronal cells":"1245.3","Renal nephron cells":"1105.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal medulla cells","Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"57426","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"6885027.3","Microglia and Neuropil":"7094394.4","Neurons":"3248467.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"109747","Protein tissue specific Intensity":{"cerebral cortex":"10974700.8"},"Antibody":["HPA030849"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"46000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Nucleoplasm","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA030849":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CACNG3","Gene synonym":[],"Ensembl":"ENSG00000006116","Gene description":"Calcium voltage-gated channel auxiliary subunit gamma 3","Uniprot":["O60359"],"Chromosome":"16","Position":"24256335-24362412","Protein class":["FDA approved drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calcium channel","Ion channel","Voltage-gated channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"67.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Retinal horizontal cells":"771.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Neuronal cells":"771.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"12","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"36","RNA cell line specific nTPM":{"Bone cancer":"3.6"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA077238":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CACYBP","Gene synonym":["S100A6BP","SIP"],"Ensembl":"ENSG00000116161","Gene description":"Calcyclin binding protein","Uniprot":["Q9HB71"],"Chromosome":"1","Position":"174999163-175012027","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Megakaryocytes":"321.4","Migrating cytotrophoblasts":"352.1","Oocytes":"548.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"548.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"140000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":46,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA025753":null,"HPA057038":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.22e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.85e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.62e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"}},{"Gene":"CAGE1","Gene synonym":["bA69L16.7","CT95","CTAG3"],"Ensembl":"ENSG00000164304","Gene description":"Cancer antigen 1","Uniprot":["Q8TC20"],"Chromosome":"6","Position":"7326656-7389742","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"testis":"4.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"141.7","Epicardial cells":"29.6","Late primary spermatocytes":"125.8","Late spermatids":"82.9","pDCs":"27.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"141.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"4.8"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029832":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":203,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA022989":null,"HPA023019":null,"HPA023195":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":2,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Vesicles","Centriolar satellite"],"Antibody RRID":{"HPA028962":null,"HPA061428":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CALHM3","Gene synonym":["bA225H22.7","FAM26A"],"Ensembl":"ENSG00000183128","Gene description":"Calcium homeostasis modulator 3","Uniprot":["Q86XJ0"],"Chromosome":"10","Position":"103472804-103479240","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Ion transport","Sensory transduction","Taste","Transport"],"Molecular function":["Calcium channel","Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"4.8","Extravillous trophoblasts":"10.9","Late spermatids":"5.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5.3","Trophoblast cells":"10.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"3.4","Ovary Serous Cystadenocarcinoma (TCGA)":"1.7","Pancreatic Adenocarcinoma (TCGA)":"3.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"pancreatic cancer":"5.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018205":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CALM3","Gene synonym":["PHKD","PHKD3"],"Ensembl":"ENSG00000160014","Gene description":"Calmodulin 3","Uniprot":["P0DP25"],"Chromosome":"19","Position":"46601074-46610782","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Long QT syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"1443.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1768.9","Hofbauer cells":"1222.1","Late primary spermatocytes":"2115.5","Late spermatids":"3493.7","Megakaryocytes":"809.8","Platelets":"2983.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"1222.1","Platelets":"2983.7","Spermatogenic cell types":"3493.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":205,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044999":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"}},{"Gene":"CALR3","Gene synonym":["CRT2","CT93","FLJ25355","MGC26577"],"Ensembl":"ENSG00000269058","Gene description":"Calreticulin 3","Uniprot":["Q96L12"],"Chromosome":"19","Position":"16479061-16496167","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Chaperone"],"Disease involvement":["Cardiomyopathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"72","RNA tissue specific nTPM":{"testis":"61.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"2.3","Early spermatids":"48.1","Late primary spermatocytes":"15.5","Late spermatids":"11.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"114","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"48.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB025749","HPA043355","HPA048460"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":57,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025749":null,"HPA043355":null,"HPA048460":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAMK4","Gene synonym":["CaMK-GR","CaMKIV"],"Ensembl":"ENSG00000152495","Gene description":"Calcium\/calmodulin dependent protein kinase IV","Uniprot":["Q16566"],"Chromosome":"5","Position":"111223653-111494886","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Immunity","Inflammatory response"],"Molecular function":["Calmodulin-binding","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"52.7","lymphoid tissue":"51.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"138.3","Bergmann glia":"274.6","Brain excitatory neurons":"599.5","Brain inhibitory neurons":"523.8","Corticotrophs":"187.5","Early spermatids":"303.9","Innate lymphoid cells":"160.3","Late primary spermatocytes":"261.5","Late spermatids":"158.6","Oligodendrocyte progenitor cells":"190.4","Other brain neurons":"158.5","Retinal bipolar cells":"309.3","T-cells":"687.4","Thymocytes":"175.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"274.6","Neuronal cells":"599.5","Spermatogenic cell types":"303.9","T-cells":"687.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"1197.4","upper rhombic lip":"1533.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"174.1"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"MAIT T-cell":"24.3","memory CD4 T-cell":"17.4","memory CD8 T-cell":"13.4","naive CD4 T-cell":"33.2","naive CD8 T-cell":"18.5","T-reg":"21.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"23","RNA blood lineage specific nTPM":{"T-cells":"33.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"17.8","Neuroblastoma":"27.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Adrenal gland - Adrenal medulla cells","Breast - T-cells","Liver - Hepatic stellate cells","Minor Salivary Gland - T-cells","Stomach - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"9291689.0","Microglia and Neuropil":"10078087.7","Neurons":"16097506.0","T-cells":"8109378.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"50324022.0"},"Antibody":["CAB004347","HPA011753","HPA017206"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":4,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"CAB004347":null,"HPA011753":null,"HPA017206":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAMKMT","Gene synonym":["C2orf34","CLNMT"],"Ensembl":"ENSG00000143919","Gene description":"Calmodulin-lysine N-methyltransferase","Uniprot":["Q7Z624"],"Chromosome":"2","Position":"44361947-44772592","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA067912":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":43,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytokinetic bridge"],"Antibody RRID":{"CAB034931":null,"HPA007656":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.55e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAMLG","Gene synonym":["CAML","GET2"],"Ensembl":"ENSG00000164615","Gene description":"Calcium modulating ligand","Uniprot":["P49069"],"Chromosome":"5","Position":"134738495-134752157","Protein class":["Essential proteins","FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["ER-Golgi transport","Host-virus interaction","Transport"],"Molecular function":null,"Disease involvement":["Congenital disorder of glycosylation","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"836.8","Late primary spermatocytes":"668.9","Late spermatids":"2733.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2733.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":38,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA052636":null,"HPA056472":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.43e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"CAPN11","Gene synonym":[],"Ensembl":"ENSG00000137225","Gene description":"Calpain 11","Uniprot":["Q9UMQ6"],"Chromosome":"6","Position":"44158811-44184401","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"28.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"31.0","Early primary spermatocytes":"10.7","Early spermatids":"21.6","Late primary spermatocytes":"117.4","Late spermatids":"11.3","Platelets":"9.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Secretory gland support":"31.0","Spermatogenic cell types":"117.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Leukemia":"1.0","Rhabdoid":"4.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":["Acrosome","Equatorial segment"],"Antibody RRID":{"CAB018070":null,"HPA030955":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAPN3","Gene synonym":["CANP3","LGMD2","LGMD2A","nCL-1","p94"],"Ensembl":"ENSG00000092529","Gene description":"Calpain 3","Uniprot":["P20807"],"Chromosome":"15","Position":"42359498-42412949","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":["Disease variant","Limb-girdle muscular dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"318.3","skeletal muscle":"848.7","tongue":"352.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"17","RNA single cell type specific nCPM":{"Oligodendrocytes":"301.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Glial cells":"301.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"415.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"294.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"37","RNA cell line specific nTPM":{"skin cancer":"228.7"},"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040052":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"CAPRIN1","Gene synonym":["caprin-1","GPIAP1","M11S1","RNG105"],"Ensembl":"ENSG00000135387","Gene description":"Cell cycle associated protein 1","Uniprot":["Q14444"],"Chromosome":"11","Position":"34051731-34102610","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation"],"Molecular function":["Protein synthesis inhibitor","RNA-binding"],"Disease involvement":["Autism","Autism spectrum disorder","Disease variant","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"504.5","Late primary spermatocytes":"511.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"511.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018126","HPA063617"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centriolar satellite","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":203,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centriolar satellite","Centrosome"],"Antibody RRID":{"HPA018126":null,"HPA063617":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.70e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.28e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"CAPS2","Gene synonym":[],"Ensembl":"ENSG00000180881","Gene description":"Calcyphosine 2","Uniprot":["Q9BXY5"],"Chromosome":"12","Position":"75275979-75390928","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"9.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"257.0","Ependymal cells":"351.0","Gonadotrophs":"250.8","Lactotrophs":"264.8","Respiratory ciliated cells":"207.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"351.0","Pituitary endocrine cells":"264.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"2.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1167226.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"31291","Protein tissue specific Intensity":{"fallopian tube":"3129104.7"},"Antibody":["HPA039542","HPA040004"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Vesicles","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Vesicles","Centrosome"],"Antibody RRID":{"HPA039542":null,"HPA040004":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAPSL","Gene synonym":["MGC26610"],"Ensembl":"ENSG00000152611","Gene description":"Calcyphosine like","Uniprot":["Q8WWF8"],"Chromosome":"5","Position":"35904288-35938779","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"choroid plexus":"86.0","fallopian tube":"104.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"149.7","Endometrial ciliated cells":"409.4","Ependymal cells":"148.5","Epididymal efferent duct ciliated cells":"536.4","Fallopian tube ciliated cells":"852.2","Late primary spermatocytes":"121.1","Late spermatids":"207.7","Respiratory ciliated cells":"771.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"852.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"60.5","ependymal cell":"199.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"27.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"52.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"2.9","Leukemia":"2.2"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Nucleoplasm","Microtubules","Primary cilium"],"Subcellular additional location":["Plasma membrane","Cytokinetic bridge"],"Antibody RRID":{"HPA046811":null,"HPA058495":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"}},{"Gene":"CAPZA1","Gene synonym":[],"Ensembl":"ENSG00000116489","Gene description":"Capping actin protein of muscle Z-line subunit alpha 1","Uniprot":["P52907"],"Chromosome":"1","Position":"112619805-112671616","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin capping","Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"741.3","Kupffer cells":"618.0","Neutrophil progenitors":"709.1","Neutrophils":"1339.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1339.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"56580205.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB045963"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":80,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB045963":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.25e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.71e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.36e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"}},{"Gene":"CAPZA3","Gene synonym":["CAPPA3","Gsg3"],"Ensembl":"ENSG00000177938","Gene description":"Capping actin protein of muscle Z-line subunit alpha 3","Uniprot":["Q96KX2"],"Chromosome":"12","Position":"18738119-18739188","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin capping","Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"86","RNA tissue specific nTPM":{"testis":"175.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"2841.2","Late spermatids":"10438.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"776","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"10438.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Calyx"],"Subcellular additional location":null,"Antibody RRID":{"HPA038688":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAPZB","Gene synonym":[],"Ensembl":"ENSG00000077549","Gene description":"Capping actin protein of muscle Z-line subunit beta","Uniprot":["P47756"],"Chromosome":"1","Position":"19338775-19485539","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin capping","Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1378.0","Esophageal apical cells":"1195.9","Hofbauer cells":"1600.0","Late spermatids":"6076.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6076.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"696.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031531"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8500000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":905,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA031531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.39e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.46e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.03e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.17e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"}},{"Gene":"CARD18","Gene synonym":["ICEBERG","pseudo-ICE","UNQ5804"],"Ensembl":"ENSG00000255501","Gene description":"Caspase recruitment domain family member 18","Uniprot":["P57730"],"Chromosome":"11","Position":"105137714-105531697","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Thiol protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skin 1":"40.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"96.0","Cytotrophoblasts":"141.8","Differentiating spermatogonia":"63.6","Early primary spermatocytes":"114.9","Early spermatids":"63.3","Extravillous trophoblasts":"86.3","Gastric progenitor cells":"107.7","Hofbauer cells":"78.9","Late primary spermatocytes":"66.5","Migrating cytotrophoblasts":"73.4","M\u00fcller glia":"113.5","Syncytiotrophoblasts":"72.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"113.5","Mononuclear phagocytes":"78.9","Proliferating cells":"107.7","Spermatogenic cell types":"114.9","Trophoblast cells":"141.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"97.7","cerebellar inhibitory":"45.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"8.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"4.7"},"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"11788","Protein cell type specific Intensity":{"Keratinocytes":"1178789.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"14553618.6"},"Antibody":["HPA038582"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038582":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CARF","Gene synonym":["ALS2CR8","FLJ21579","NYD-SP24"],"Ensembl":"ENSG00000138380","Gene description":"Calcium responsive transcription factor","Uniprot":["Q8N187"],"Chromosome":"2","Position":"202912214-202988263","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"109.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034557","HPA043191"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":5,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoli fibrillar center","Cytosol"],"Antibody RRID":{"HPA034557":null,"HPA043191":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.77e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"}},{"Gene":"CARNMT1","Gene synonym":["C9orf41","FLJ25795"],"Ensembl":"ENSG00000156017","Gene description":"Carnosine N-methyltransferase 1","Uniprot":["Q8N4J0"],"Chromosome":"9","Position":"74980790-75028423","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"348.1","Late primary spermatocytes":"213.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"348.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026756":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"}},{"Gene":"CARS1","Gene synonym":["CARS"],"Ensembl":"ENSG00000110619","Gene description":"Cysteinyl-tRNA synthetase 1","Uniprot":["P49589"],"Chromosome":"11","Position":"3000922-3057613","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase"],"Disease involvement":["Cancer-related genes","Disease variant","Dwarfism","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"91.6","Late primary spermatocytes":"101.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"101.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"140000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB075734":null,"CAB075735":null,"CAB075736":null,"CAB075737":null,"HPA002383":null,"HPA002384":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025515":null,"CAB079776":null,"HPA046278":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.21e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAST","Gene synonym":[],"Ensembl":"ENSG00000153113","Gene description":"Calpastatin","Uniprot":["P20810"],"Chromosome":"5","Position":"96525267-96779595","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Thiol protease inhibitor"],"Disease involvement":["Cancer-related genes","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"3885.9","Ocular epithelial cells":"2239.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"3885.9","Barrier epithelial cells":"2239.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7900000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":5,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB009491":null,"HPA036881":null,"HPA036882":null,"HPA075906":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"}},{"Gene":"CATIP","Gene synonym":["C2orf62","MGC50811"],"Ensembl":"ENSG00000158428","Gene description":"Ciliogenesis associated TTC17 interacting protein","Uniprot":["Q7Z7H3"],"Chromosome":"2","Position":"218356857-218368099","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"15.4","fallopian tube":"18.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"29.9","Endometrial ciliated cells":"42.0","Ependymal cells":"74.6","Epididymal efferent duct ciliated cells":"78.1","Fallopian tube ciliated cells":"111.4","Late primary spermatocytes":"37.1","Late spermatids":"31.4","Respiratory ciliated cells":"113.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"113.4","Spermatogenic cell types":"37.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"12","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"25.4","ependymal cell":"80.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"8.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"1.4"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3332","Protein cell type specific Intensity":{"Fallopian tube cells":"333212.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"276028.3"},"Antibody":["HPA044818"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Connecting piece","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":14,"Subcellular main location":["Connecting piece"],"Subcellular additional location":["Mid piece"],"Antibody RRID":{"HPA044818":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.97e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.01e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.74e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"}},{"Gene":"CATSPER1","Gene synonym":["CATSPER"],"Ensembl":"ENSG00000175294","Gene description":"Cation channel sperm associated 1","Uniprot":["Q8NEC5"],"Chromosome":"11","Position":"66016752-66026479","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Differentiation","Ion transport","Spermatogenesis","Transport"],"Molecular function":["Calcium channel","Developmental protein","Ion channel","Voltage-gated channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"33","RNA tissue specific nTPM":{"testis":"16.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"42.9","Extravillous trophoblasts":"9.8","Late primary spermatocytes":"36.9","Mast cells":"47.1","Megakaryocytes":"12.4","monocytes":"18.2","NK-cells":"12.1","Platelets":"36.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mast cells":"47.1","Mononuclear phagocytes":"18.2","Platelets":"36.6","Spermatogenic cell types":"42.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"1.1","vascular associated smooth muscle cell":"1.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"16.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Minor Salivary Gland - Macrophages","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044528"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":97,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA044528":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.38e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CATSPER2","Gene synonym":[],"Ensembl":"ENSG00000166762","Gene description":"Cation channel sperm associated 2","Uniprot":["Q96P56"],"Chromosome":"15","Position":"43628503-43668118","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Differentiation","Ion transport","Spermatogenesis","Transport"],"Molecular function":["Calcium channel","Developmental protein","Ion channel","Voltage-gated channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"21.4","testis":"14.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"154.4","Cone photoreceptor cells":"196.7","Corticotrophs":"142.5","Rod photoreceptor cells":"306.3","Sertoli cells":"144.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"306.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042709"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles","Plasma membrane","Primary cilium","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":["End piece"],"Subcellular additional location":["Vesicles","Plasma membrane","Primary cilium","Principal piece"],"Antibody RRID":{"HPA042709":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"}},{"Gene":"CATSPER3","Gene synonym":["CACRC"],"Ensembl":"ENSG00000152705","Gene description":"Cation channel sperm associated 3","Uniprot":["Q86XQ3"],"Chromosome":"5","Position":"134967907-135011696","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Differentiation","Ion transport","Spermatogenesis","Transport"],"Molecular function":["Calcium channel","Developmental protein","Ion channel","Voltage-gated channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"28.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"36","RNA single cell type specific nCPM":{"Early spermatids":"201.6","Late primary spermatocytes":"145.1","Late spermatids":"79.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"52","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"201.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"1.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA049004":null,"HPA067379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045257":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA035134":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"}},{"Gene":"CATSPERD","Gene synonym":["MGC39581","TMEM146"],"Ensembl":"ENSG00000174898","Gene description":"Cation channel sperm associated auxiliary subunit delta","Uniprot":["Q86XM0"],"Chromosome":"19","Position":"5720637-5778734","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"82","RNA tissue specific nTPM":{"testis":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"166.5","Endometrial ciliated cells":"91.2","Ependymal cells":"66.4","Epididymal efferent duct ciliated cells":"174.2","Fallopian tube ciliated cells":"250.7","Late primary spermatocytes":"52.8","Late spermatids":"219.1","Oocytes":"46.1","Respiratory ciliated cells":"249.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"250.7","Spermatogenic cell types":"219.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"21","RNA single nuclei brain specific nCPM":{"ependymal cell":"95.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":5,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA024056":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CATSPERE","Gene synonym":["C1orf101","MGC33370"],"Ensembl":"ENSG00000179397","Gene description":"Catsper channel auxiliary subunit epsilon","Uniprot":["Q5SY80"],"Chromosome":"1","Position":"244454377-244641177","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"20.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"120.6","Neutrophil progenitors":"119.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"119.1","Spermatogenic cell types":"120.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":["Annulus"],"Antibody RRID":{"HPA077676":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CATSPERG","Gene synonym":["C19orf15","DKFZp434A1022","FLJ46353"],"Ensembl":"ENSG00000099338","Gene description":"Cation channel sperm associated auxiliary subunit gamma","Uniprot":["Q6ZRH7"],"Chromosome":"19","Position":"38335775-38370943","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins","Transporters"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"30.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"72.8","Enterocytes":"68.1","Late primary spermatocytes":"65.0","Late spermatids":"95.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"95.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"448","Protein cell type specific Intensity":{"Oocytes":"44841.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052777"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mid piece","Principal piece"],"Secretome location":"Secreted in male reproductive system","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":null,"Subcellular main location":["Mid piece"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA052777":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CATSPERZ","Gene synonym":["C11orf20","DKFZP566E164","TEX40"],"Ensembl":"ENSG00000219435","Gene description":"Catsper channel auxiliary subunit zeta","Uniprot":["Q9NTU4"],"Chromosome":"11","Position":"64300358-64304770","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"152","RNA tissue specific nTPM":{"testis":"544.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"15.6","Late primary spermatocytes":"22.1","Late spermatids":"73.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"73.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052822"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Primary cilium tip","Cytosol","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Primary cilium tip","Mid piece"],"Subcellular additional location":["Cytosol","Principal piece"],"Antibody RRID":{"HPA052822":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CAVIN3","Gene synonym":["cavin-3","HSRBC","MGC20400","PRKCDBP","SRBC"],"Ensembl":"ENSG00000170955","Gene description":"Caveolae associated protein 3","Uniprot":["Q969G5"],"Chromosome":"11","Position":"6318946-6320532","Protein class":["Predicted intracellular proteins"],"Biological process":["Biological rhythms"],"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"292.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"296.0","Fibroblasts":"148.6","Hepatic stellate cells":"290.5","Late primary spermatocytes":"813.1","Late spermatids":"291.9","Melanocytes":"212.0","Pericytes":"192.0","Schwann cells":"200.2","Smooth muscle cells":"243.1","Vascular smooth muscle cells":"430.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mural cells":"430.7","Spermatogenic cell types":"813.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"pericyte":"113.3","vascular associated smooth muscle cell":"154.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"16.2","myeloid DC":"42.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"42.9","monocytes":"16.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"262070991.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA055136","HPA073327"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":32,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA055136":null,"HPA073327":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.87e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"}},{"Gene":"CAVIN4","Gene synonym":["cavin-4","MURC"],"Ensembl":"ENSG00000170681","Gene description":"Caveolae associated protein 4","Uniprot":["Q5BKX8"],"Chromosome":"9","Position":"100578079-100588389","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Myogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"skeletal muscle":"258.4","tongue":"86.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Myonuclei":"172.6","Thymic myoid cells":"488.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"172.6","Stromal cells":"488.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"45.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"3.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"6.6"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"284759","Protein cell type specific Intensity":{"Capillaries":"15849658.1","Cardiomyocytes":"42325394.5","Skeletal myofibers":"27252596.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"361812","Protein tissue specific Intensity":{"heart muscle":"24401726.0","skeletal muscle":"47960771.1"},"Antibody":["HPA020973","HPA020987","HPA021021"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":2,"Subcellular main location":["Golgi apparatus","Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA020973":null,"HPA020987":null,"HPA021021":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":10,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA021773":null,"HPA026699":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.79e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CBLN1","Gene synonym":[],"Ensembl":"ENSG00000102924","Gene description":"Cerebellin 1 precursor","Uniprot":["P23435"],"Chromosome":"16","Position":"49277917-49281838","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"brain":"425.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"64.0","Early spermatids":"86.4","Late primary spermatocytes":"153.3","Late spermatids":"522.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"522.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"12","RNA single nuclei brain specific nCPM":{"upper rhombic lip":"168.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"8.0","Thyroid Carcinoma (TCGA)":"15.5"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"cerebellum":"239.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"12.2","Neuroblastoma":"18.5"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2100000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":["Cytosol","Flagellar centriole","Mid piece","Principal piece"],"Subcellular additional location":["Perinuclear theca","Calyx"],"Antibody RRID":{"HPA056335":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"}},{"Gene":"CBX5","Gene synonym":["HP1","HP1-ALPHA","HP1Hs-alpha"],"Ensembl":"ENSG00000094916","Gene description":"Chromobox 5","Uniprot":["P45973"],"Chromosome":"12","Position":"54230942-54280133","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"112.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"510.8","Late primary spermatocytes":"311.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"510.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"557.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":209,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB017548":null,"HPA016699":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.76e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"}},{"Gene":"CC2D2B","Gene synonym":["bA248J23.4","bA690P14.3","C10orf130","C10orf131"],"Ensembl":"ENSG00000188649","Gene description":"Coiled-coil and C2 domain containing 2B","Uniprot":["Q6DHV5"],"Chromosome":"10","Position":"95907603-96033745","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"127.9","Astrocytes":"83.7","Cardiomyocytes":"261.9","Epicardial cells":"127.4","Late primary spermatocytes":"92.0","Microglia":"83.2","Myonuclei":"75.0","Neutrophil progenitors":"67.3","Neutrophils":"92.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"127.9","Barrier epithelial cells":"127.4","Myocytes":"261.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"102.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Basal body","Cytosol"],"Antibody RRID":{"HPA044091":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.71e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"}},{"Gene":"CCDC102B","Gene synonym":["ACY1L","AN","C18orf14","FLJ23594","HsT1731"],"Ensembl":"ENSG00000150636","Gene description":"Coiled-coil domain containing 102B","Uniprot":["Q68D86"],"Chromosome":"18","Position":"68715209-69055189","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"26.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"131.8","Fibro-adipogenic progenitors":"191.9","Fibroblasts":"101.1","Late spermatids":"102.6","Leydig cells":"97.7","Lymphatic endothelial cells":"127.3","Pericytes":"446.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Fibro-adipogenic progenitors":"191.9","Mural cells":"446.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"370.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"plasmacytoid DC":"9.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"9.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"12.8"},"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Liver - Hepatic stellate cells","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"595155.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"37536","Protein tissue specific Intensity":{"intestine":"3086923.9","Stomach":"4420257.8"},"Antibody":["HPA040623","HPA048194"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":93,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040623":null,"HPA048194":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA058585":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA071931":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":11,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA045120":null,"HPA050621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040759":null,"HPA040869":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.94e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.88e-5"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC121","Gene synonym":["FLJ13646","FLJ43364"],"Ensembl":"ENSG00000176714","Gene description":"Coiled-coil domain containing 121","Uniprot":["Q6ZUS5"],"Chromosome":"2","Position":"27625638-27629012","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"23.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"245.5","Fallopian tube ciliated cells":"28.3","Late primary spermatocytes":"92.9","Late spermatids":"45.6","Respiratory ciliated cells":"27.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"245.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"18.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"10.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":4,"Subcellular main location":["Actin filaments","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA051791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.60e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"}},{"Gene":"CCDC126","Gene synonym":["FLJ23031"],"Ensembl":"ENSG00000169193","Gene description":"Coiled-coil domain containing 126","Uniprot":["Q96EE4"],"Chromosome":"7","Position":"23597382-23644708","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"32.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"783.0","Late primary spermatocytes":"254.4","Late spermatids":"762.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"783.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"basophil":"480.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"23","RNA blood lineage specific nTPM":{"granulocytes":"480.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"247006.8","Pancreas epithelial cells":"433580.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"278356.8","liver":"158973.1","ovary":"76058.1"},"Antibody":["HPA010969","HPA026883"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"10000000","Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA010969":null,"HPA026883":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.57e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-1"}},{"Gene":"CCDC13","Gene synonym":["FLJ25467"],"Ensembl":"ENSG00000244607","Gene description":"Coiled-coil domain containing 13","Uniprot":["Q8IYE1"],"Chromosome":"3","Position":"42705756-42773253","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"2.7","retina":"4.0","testis":"2.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"5.9","Choroid plexus epithelial cells":"19.6","Distal convoluted tubule cells":"6.6","Endometrial ciliated cells":"7.7","Ependymal cells":"69.4","Epididymal efferent duct ciliated cells":"13.4","Fallopian tube ciliated cells":"7.9","Loop of henle epithelial cells":"7.5","Podocytes":"6.7","Proximal tubule cells":"5.7","Renal collecting duct intercalated cells":"7.1","Renal collecting duct principal cells":"7.0","Renal connecting tubule cells":"6.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"69.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"19.4","ependymal cell":"71.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"29685","Protein cell type specific Intensity":{"Fallopian tube cells":"2968505.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"17044","Protein tissue specific Intensity":{"fallopian tube":"1704386.6"},"Antibody":["HPA047429"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centriolar satellite","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":37,"Subcellular main location":["Centriolar satellite","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA047429":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC134","Gene synonym":["FLJ22349"],"Ensembl":"ENSG00000100147","Gene description":"Coiled-coil domain containing 134","Uniprot":["Q9H6E4"],"Chromosome":"22","Position":"41800679-41832164","Protein class":["Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Osteogenesis imperfecta"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"66.8","Cone photoreceptor cells":"64.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"43.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"5731750.1","lymphoid tissue":"1444841.9","salivary gland":"4451914.6"},"Antibody":["HPA003936","HPA075348"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA003936":null,"HPA075348":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"}},{"Gene":"CCDC136","Gene synonym":["DKFZP434G156","KIAA1793","NAG6"],"Ensembl":"ENSG00000128596","Gene description":"Coiled-coil domain containing 136","Uniprot":["Q96JN2"],"Chromosome":"7","Position":"128790757-128822132","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Fertilization","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"82.4","retina":"48.7","testis":"175.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"787.0","Late primary spermatocytes":"1028.7","Late spermatids":"3444.6","Retinal bipolar cells":"333.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3444.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"15.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"25.2"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"70860","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"4076513.3","Microglia and Neuropil":"8312601.7","Neurons":"8868815.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"48452","Protein tissue specific Intensity":{"cerebral cortex":"4845208.5"},"Antibody":["HPA010646","HPA071015"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles","Plasma membrane","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA049899":null,"HPA054223":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.25e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056946":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.88e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"}},{"Gene":"CCDC146","Gene synonym":["KIAA1505","MBO2"],"Ensembl":"ENSG00000135205","Gene description":"Coiled-coil domain containing 146","Uniprot":["Q8IYE0"],"Chromosome":"7","Position":"77122434-77329533","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"32.0","testis":"20.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"400.8","Endometrial ciliated cells":"702.1","Ependymal cells":"730.8","Epididymal efferent duct absorptive cells":"594.5","Epididymal efferent duct ciliated cells":"952.7","Fallopian tube ciliated cells":"806.4","Late primary spermatocytes":"563.2","Respiratory ciliated cells":"1054.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1054.6","Ductal cells":"594.5","Spermatogenic cell types":"563.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"801.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"14.4","neutrophil":"15.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"15.5","NK-cells":"5.4","T-cells":"4.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Lung - Respiratory ciliated cells","Prostate - Urothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"66599","Protein cell type specific Intensity":{"Fallopian tube cells":"6659865.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"319997","Protein tissue specific Intensity":{"fallopian tube":"31999711.7"},"Antibody":["HPA020082","HPA020105"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC150","Gene synonym":["FLJ39660"],"Ensembl":"ENSG00000144395","Gene description":"Coiled-coil domain containing 150","Uniprot":["Q8NCX0"],"Chromosome":"2","Position":"196639554-196763490","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"2.4","testis":"4.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"29.7","Early primary spermatocytes":"43.3","Early spermatids":"36.6","Erythrocyte progenitors":"25.2","Late primary spermatocytes":"83.2","Late spermatids":"22.1","Monocyte progenitors":"29.8","Oligodendrocytes":"21.9","Oocytes":"32.2","Undifferentiated spermatogonia":"37.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"83.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"32.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"2.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA048104":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC153","Gene synonym":["LOC283152"],"Ensembl":"ENSG00000248712","Gene description":"Coiled-coil domain containing 153","Uniprot":["Q494R4"],"Chromosome":"11","Position":"119190250-119196769","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"23.3","fallopian tube":"22.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"112.4","Epididymal efferent duct ciliated cells":"242.6","Fallopian tube ciliated cells":"256.8","Respiratory ciliated cells":"256.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Ciliated cells":"256.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"59.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"neutrophil":"24.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"24.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA041158":null,"HPA043535":null,"HPA048237":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC166","Gene synonym":[],"Ensembl":"ENSG00000255181","Gene description":"Coiled-coil domain containing 166","Uniprot":["P0CW27"],"Chromosome":"8","Position":"143706694-143708109","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"32","RNA tissue specific nTPM":{"testis":"3.9"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA025058":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA048184":null,"HPA058793":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear speckles","Vesicles"],"Antibody RRID":{"HPA040527":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA027114":null,"HPA027185":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.97e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"}},{"Gene":"CCDC171","Gene synonym":["bA536D16.1","bA778P13.1","C9orf93","Em:AL513423.1","FLJ39267","FLJ46740"],"Ensembl":"ENSG00000164989","Gene description":"Coiled-coil domain containing 171","Uniprot":["Q6TFL3"],"Chromosome":"9","Position":"15553043-16061663","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"233.6","Hematopoietic stem cells":"329.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Stem cells":"329.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"2.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"8.2"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA019803":null,"HPA019806":null,"HPA024133":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043468":null,"HPA060129":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"}},{"Gene":"CCDC175","Gene synonym":["C14orf38"],"Ensembl":"ENSG00000151838","Gene description":"Coiled-coil domain containing 175","Uniprot":["P0C221"],"Chromosome":"14","Position":"59504539-59576812","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.1","choroid plexus":"2.6","testis":"2.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"90.4","Choroid plexus epithelial cells":"88.0","Early primary spermatocytes":"70.2","Ependymal cells":"187.7","Gonadotrophs":"43.1","Hematopoietic stem cells":"89.3","Megakaryocyte progenitors":"182.9","Pituicytes\/FSCs":"42.8","Respiratory ciliated cells":"56.8","Sertoli cells":"76.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"187.7","Megakaryocytes":"182.9","Neuronal cells":"90.4","Reproductive supporting cells":"76.2","Stem cells":"89.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"71.2","ependymal cell":"184.9","upper rhombic lip":"260.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"cerebellum":"39.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"829","Protein cell type specific Intensity":{"Smooth muscle cells":"82891.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"6535","Protein tissue specific Intensity":{"lung":"289398.0","Stomach":"1017515.7"},"Antibody":["HPA004200"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA004200":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC178","Gene synonym":["C18orf34","FLJ44050"],"Ensembl":"ENSG00000166960","Gene description":"Coiled-coil domain containing 178","Uniprot":["Q5BJE1"],"Chromosome":"18","Position":"32937402-33441101","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"10.3","ovary":"9.4","testis":"14.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"84.9","Distal convoluted tubule cells":"231.1","Early primary spermatocytes":"70.5","Early spermatids":"79.4","Late primary spermatocytes":"129.4","Late spermatids":"120.4","Loop of henle epithelial cells":"144.1","Renal connecting tubule cells":"466.0","Somatotrophs":"65.9","Undifferentiated spermatogonia":"59.1","Vascular endothelial cells":"65.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"466.0","Renal nephron cells":"231.1","Spermatogenic cell types":"129.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"49.5","ependymal cell":"41.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"2.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023446":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Primary cilium tip","Mid piece"],"Antibody RRID":{"HPA043812":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA014569":null,"HPA018019":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":30,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA035424":null,"HPA061710":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.32e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA044395":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC30","Gene synonym":["FLJ20972","LOC728621","PFD6L"],"Ensembl":"ENSG00000186409","Gene description":"Coiled-coil domain containing 30","Uniprot":["Q5VVM6"],"Chromosome":"1","Position":"42463221-42657190","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"9.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"773.6","Endometrial ciliated cells":"314.6","Ependymal cells":"1267.3","Fallopian tube ciliated cells":"341.2","Lactotrophs":"301.4","Proximal tubule cells":"298.1","Respiratory ciliated cells":"702.0","Somatotrophs":"296.5","Thyrotrophs":"257.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"1267.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"555.3","ependymal cell":"1297.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036344":null,"HPA036345":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":20,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"}},{"Gene":"CCDC34","Gene synonym":["L15","NY-REN-41","RAMA3"],"Ensembl":"ENSG00000109881","Gene description":"Coiled-coil domain containing 34","Uniprot":["Q96HJ3"],"Chromosome":"11","Position":"27330827-27363234","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"48.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"271.9","Early primary spermatocytes":"211.5","Early spermatids":"324.2","Endometrial ciliated cells":"150.8","Epididymal efferent duct ciliated cells":"168.7","Late primary spermatocytes":"606.6","Oocytes":"152.0","Undifferentiated spermatogonia":"156.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"606.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Outer root sheath cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"5772","Protein cell type specific Intensity":{"Fallopian tube cells":"577241.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"90","Protein tissue specific Intensity":{"fallopian tube":"8978.9"},"Antibody":["HPA037574"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear membrane","Nucleoli fibrillar center","Calyx","Connecting piece","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":null,"Subcellular main location":["Nuclear membrane","Nucleoli fibrillar center","Calyx","Mid piece"],"Subcellular additional location":["Connecting piece","Principal piece","End piece"],"Antibody RRID":{"HPA037574":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.53e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.31e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.34e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.83e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"}},{"Gene":"CCDC38","Gene synonym":["FLJ40089"],"Ensembl":"ENSG00000165972","Gene description":"Coiled-coil domain containing 38","Uniprot":["Q502W7"],"Chromosome":"12","Position":"95867048-95942635","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"15.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"36.5","Early spermatids":"86.2","Late primary spermatocytes":"253.3","Late spermatids":"46.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"33","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"253.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":2,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body","Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA035363":null,"HPA035364":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.68e-6"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Microtubules","Primary cilium","Cytosol"],"Subcellular additional location":["Cytokinetic bridge","Mid piece"],"Antibody RRID":{"HPA022974":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.33e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"}},{"Gene":"CCDC42","Gene synonym":["CCDC42A","FLJ32734"],"Ensembl":"ENSG00000161973","Gene description":"Coiled-coil domain containing 42","Uniprot":["Q96M95"],"Chromosome":"17","Position":"8729935-8745219","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"64","RNA tissue specific nTPM":{"testis":"90.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Late primary spermatocytes":"623.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"80","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"623.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":23,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA038555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.95e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.99e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.09e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"}},{"Gene":"CCDC61","Gene synonym":["hVFL3","VFL3"],"Ensembl":"ENSG00000104983","Gene description":"Coiled-coil domain containing 61","Uniprot":["Q9Y6R9"],"Chromosome":"19","Position":"45995461-46021318","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"6.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"6.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA040325":null,"HPA061548":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA039021":null,"HPA058741":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC63","Gene synonym":["FLJ35843","ODA5"],"Ensembl":"ENSG00000173093","Gene description":"Coiled-coil domain containing 63","Uniprot":["Q8NA47"],"Chromosome":"12","Position":"110846769-110907535","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"16.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"395.4","Late primary spermatocytes":"227.1","Late spermatids":"389.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"395.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Nucleoplasm","Principal piece"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA043927":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC65","Gene synonym":["CFAP250","CILD27","DRC2","FAP250","FLJ35732","NYD-SP28"],"Ensembl":"ENSG00000139537","Gene description":"Coiled-coil domain containing 65","Uniprot":["Q8IXS2"],"Chromosome":"12","Position":"48904110-48931840","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"18.3","fallopian tube":"25.0","testis":"34.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"111.3","Endometrial ciliated cells":"144.8","Epicardial cells":"272.9","Fallopian tube ciliated cells":"184.7","Late primary spermatocytes":"291.5","Respiratory ciliated cells":"189.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"272.9","Ciliated cells":"189.8","Spermatogenic cell types":"291.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"gdT-cell":"8.8","MAIT T-cell":"9.1","memory CD4 T-cell":"7.5","memory CD8 T-cell":"7.3","naive CD4 T-cell":"4.6","naive CD8 T-cell":"6.2","T-reg":"4.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"T-cells":"9.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Vesicles","Primary cilium transition zone","Centriolar satellite"],"Subcellular additional location":["Mid piece","Principal piece","Annulus"],"Antibody RRID":{"HPA038520":null,"HPA057573":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"}},{"Gene":"CCDC66","Gene synonym":["DKFZp686C0433"],"Ensembl":"ENSG00000180376","Gene description":"Coiled-coil domain containing 66","Uniprot":["A2RUB6"],"Chromosome":"3","Position":"56557161-56621837","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":4,"Subcellular main location":["Primary cilium","Centriolar satellite","Perinuclear theca"],"Subcellular additional location":["Vesicles","Plasma membrane","Cell Junctions","Midbody ring","Cytosol","End piece"],"Antibody RRID":{"HPA044185":null,"HPA051937":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"CCDC7","Gene synonym":["BIOT2","C10orf68","FLJ13031","FLJ32762"],"Ensembl":"ENSG00000216937","Gene description":"Coiled-coil domain containing 7","Uniprot":["Q96M83"],"Chromosome":"10","Position":"32446140-32882874","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"29","RNA tissue specific nTPM":{"testis":"74.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"690.7","Late primary spermatocytes":"696.6","Late spermatids":"2169.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2169.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Mitotic spindle","Cytosol"],"Antibody RRID":{"HPA075536":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC74A","Gene synonym":["FLJ40345"],"Ensembl":"ENSG00000163040","Gene description":"Coiled-coil domain containing 74A","Uniprot":["Q96AQ1"],"Chromosome":"2","Position":"131527675-131533666","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"62.7","testis":"70.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"407.2","Endometrial ciliated cells":"83.4","Epididymal efferent duct ciliated cells":"203.1","Fallopian tube ciliated cells":"175.7","Late primary spermatocytes":"396.8","Late spermatids":"413.8","Respiratory ciliated cells":"202.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"203.1","Spermatogenic cell types":"413.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"45.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"59.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA046284":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.20e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.41e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"}},{"Gene":"CCDC74B","Gene synonym":["DKFZp434E2321"],"Ensembl":"ENSG00000152076","Gene description":"Coiled-coil domain containing 74B","Uniprot":["Q96LY2"],"Chromosome":"2","Position":"130139287-130145134","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"51.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"49.0","Early primary spermatocytes":"60.8","Early spermatids":"304.3","Epididymal efferent duct ciliated cells":"114.2","Fallopian tube ciliated cells":"115.2","Late primary spermatocytes":"351.0","Late spermatids":"177.2","Respiratory ciliated cells":"121.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"121.5","Spermatogenic cell types":"351.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"51.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"19.8"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA046284":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":4,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA038854":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.38e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"}},{"Gene":"CCDC81","Gene synonym":["FLJ16339","FLJ23514"],"Ensembl":"ENSG00000149201","Gene description":"Coiled-coil domain containing 81","Uniprot":["Q6ZN84"],"Chromosome":"11","Position":"86374736-86423109","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"15.8","fallopian tube":"25.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"51.6","Endometrial ciliated cells":"115.8","Ependymal cells":"198.4","Epididymal efferent duct ciliated cells":"42.4","Extravillous trophoblasts":"40.8","Fallopian tube ciliated cells":"139.0","Late primary spermatocytes":"55.3","Migrating cytotrophoblasts":"46.2","Pituitary stem cells":"113.0","Respiratory ciliated cells":"123.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"198.4","Spermatogenic cell types":"55.3","Stem cells":"113.0","Trophoblast cells":"46.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"223.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"1.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Lung - Respiratory ciliated cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4637","Protein cell type specific Intensity":{"Fallopian tube cells":"463684.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"16640","Protein tissue specific Intensity":{"fallopian tube":"1664018.7"},"Antibody":["HPA040745"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Plasma membrane","Basal body"],"Subcellular additional location":null,"Antibody RRID":{"HPA040745":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC82","Gene synonym":["FLJ23518"],"Ensembl":"ENSG00000149231","Gene description":"Coiled-coil domain containing 82","Uniprot":["Q8N4S0"],"Chromosome":"11","Position":"96349241-96389956","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"500.4","Late primary spermatocytes":"484.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"500.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA038704":null,"HPA070631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-4"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.26e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA039882":null,"HPA075087":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":22,"Subcellular main location":["Nucleoli","Nucleoli rim","Mitotic chromosome"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041117":null,"HPA041540":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.44e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.00e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.37e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.61e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":7,"Subcellular main location":["Nucleoli","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA079508":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCDC88A","Gene synonym":["APE","FLJ10392","GIV","GRDN","HkRP1","KIAA1212"],"Ensembl":"ENSG00000115355","Gene description":"Coiled-coil domain containing 88A","Uniprot":["Q3V6T2"],"Chromosome":"2","Position":"55287842-55419895","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Neurogenesis"],"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":["Epilepsy","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"65.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"518.3","Early spermatids":"952.9","Late primary spermatocytes":"485.1","Late spermatids":"1269.6","Monocyte progenitors":"528.8","Oligodendrocytes":"952.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"952.9","Spermatogenic cell types":"1269.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"6.1","classical monocyte":"7.1","intermediate monocyte":"7.0","myeloid DC":"11.3","non-classical monocyte":"6.8","plasmacytoid DC":"23.7"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"23.7","granulocytes":"6.1","monocytes":"7.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":21,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA038101":null,"HPA038102":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.60e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.26e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"}},{"Gene":"CCDC89","Gene synonym":["FLJ38159"],"Ensembl":"ENSG00000179071","Gene description":"Coiled-coil domain containing 89","Uniprot":["Q8N998"],"Chromosome":"11","Position":"85683848-85686195","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"7.3","testis":"24.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"432.6","Late primary spermatocytes":"363.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"432.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"17.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"3.0"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA040628":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"}},{"Gene":"CCDC90B","Gene synonym":["MDS011","MDS025"],"Ensembl":"ENSG00000137500","Gene description":"Coiled-coil domain containing 90B","Uniprot":["Q9GZT6"],"Chromosome":"11","Position":"83259081-83286390","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"244.7","Early spermatids":"452.8","Esophageal apical cells":"266.2","Late primary spermatocytes":"510.1","Late spermatids":"306.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"266.2","Spermatogenic cell types":"510.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":15,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA011130":null,"HPA011931":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.85e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"CCDC91","Gene synonym":["DKFZp779L1558","FLJ11088","p56"],"Ensembl":"ENSG00000123106","Gene description":"Coiled-coil domain containing 91","Uniprot":["Q7Z6B0"],"Chromosome":"12","Position":"28133249-28581511","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"14270.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"14270.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"27751019.0"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038169"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Acrosome","Equatorial segment","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Nucleoplasm","Golgi apparatus","Acrosome"],"Subcellular additional location":["Equatorial segment","Flagellar centriole"],"Antibody RRID":{"HPA038169":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.13e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.50e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.55e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"}},{"Gene":"CCDC92","Gene synonym":["FLJ22471"],"Ensembl":"ENSG00000119242","Gene description":"Coiled-coil domain containing 92","Uniprot":["Q53HC0"],"Chromosome":"12","Position":"123918660-123972831","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Immunity","Innate immunity"],"Molecular function":["Antiviral protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"138.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"131.6","Brain inhibitory neurons":"126.0","Other brain neurons":"109.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":12,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA038560":null,"HPA057580":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"}},{"Gene":"CCDC96","Gene synonym":["FLJ90575"],"Ensembl":"ENSG00000173013","Gene description":"Coiled-coil domain containing 96","Uniprot":["Q2M329"],"Chromosome":"4","Position":"7040849-7043001","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"61.6"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"6.4"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"24174","Protein cell type specific Intensity":{"Fallopian tube cells":"2417361.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"35042","Protein tissue specific Intensity":{"fallopian tube":"3504155.7"},"Antibody":["HPA047546"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047546":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"}},{"Gene":"CCDC97","Gene synonym":["FLJ40267","MGC20255"],"Ensembl":"ENSG00000142039","Gene description":"Coiled-coil domain containing 97","Uniprot":["Q96F63"],"Chromosome":"19","Position":"41310172-41324873","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Innate lymphoid cells":"82.2","NK-cells":"78.8","pDCs":"97.4","T-cells":"84.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"361078.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"2851863.2"},"Antibody":["HPA043320","HPA043572"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"}},{"Gene":"CCER1","Gene synonym":["C12orf12","MGC26598"],"Ensembl":"ENSG00000197651","Gene description":"Coiled-coil glutamate rich protein 1","Uniprot":["Q8TC90"],"Chromosome":"12","Position":"90905622-90955176","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"363","RNA tissue specific nTPM":{"testis":"36.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"116","RNA single cell type specific nCPM":{"Early spermatids":"455.3","Late primary spermatocytes":"395.5","Late spermatids":"131.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"283","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"455.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":40,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA054167":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.97e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"}},{"Gene":"CCIN","Gene synonym":["BTBD20","KBTBD14"],"Ensembl":"ENSG00000185972","Gene description":"Calicin","Uniprot":["Q13939"],"Chromosome":"9","Position":"36169388-36171334","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"39","RNA tissue specific nTPM":{"testis":"70.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1121.2","Late primary spermatocytes":"230.1","Late spermatids":"304.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"173","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1121.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019611","HPA058717"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Perinuclear theca","Calyx"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":4,"Subcellular main location":["Calyx"],"Subcellular additional location":["Nucleoplasm","Perinuclear theca"],"Antibody RRID":{"HPA019611":null,"HPA058717":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCL18","Gene synonym":["AMAC-1","CKb7","DC-CK1","DCCK1","MIP-4","PARC","SCYA18"],"Ensembl":"ENSG00000275385","Gene description":"C-C motif chemokine ligand 18","Uniprot":["P55774"],"Chromosome":"17","Position":"36064272-36072032","Protein class":["Cancer-related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Chemotaxis","Inflammatory response"],"Molecular function":["Cytokine"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"lung":"46.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"9.4","Late spermatids":"4.7","Macrophages":"4.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"4.0","Spermatogenic cell types":"9.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":55500000,"Blood concentration - Conc. blood MS [pg\/L]":"2000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCL20","Gene synonym":["CKb4","exodus-1","LARC","MIP-3a","SCYA20","ST38"],"Ensembl":"ENSG00000115009","Gene description":"C-C motif chemokine ligand 20","Uniprot":["P78556"],"Chromosome":"2","Position":"227805739-227817564","Protein class":["Predicted secreted proteins"],"Biological process":["Chemotaxis","Inflammatory response"],"Molecular function":["Antibiotic","Antimicrobial","Cytokine"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"gallbladder":"153.1","lymphoid tissue":"155.0","urinary bladder":"179.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"784.1","Enterocytes":"349.9","Esophageal apical cells":"721.8","Esophageal basal cells":"329.4","Esophageal suprabasal cells":"647.9","Fallopian secretory cells":"263.2","Gastric progenitor cells":"472.9","monocytes":"883.6","Neutrophils":"593.0","Pancreatic duct cells":"227.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"721.8","Glandular cells":"784.1","Mononuclear phagocytes":"883.6","Neutrophils":"593.0","Suprabasal cells":"647.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"34","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"4.8","leukocyte":"3.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"2.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"T-cells":"2.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - 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Conc. blood IM [pg\/L]":28000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.25e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.48e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"}},{"Gene":"CCNA1","Gene synonym":["CT146"],"Ensembl":"ENSG00000133101","Gene description":"Cyclin A1","Uniprot":["P78396"],"Chromosome":"13","Position":"36431520-36442870","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Cyclin"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"20.9","testis":"76.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"554.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"554.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"25.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"32.4","Uterine Corpus Endometrial Carcinoma (TCGA)":"31.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"104","RNA blood cell specific nTPM":{"basophil":"49.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"301","RNA blood lineage specific nTPM":{"granulocytes":"49.6"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"66.7"},"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Lung - Respiratory ciliated cells","Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"273","Protein cell type specific Intensity":{"Pancreas epithelial cells":"27331.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"264","Protein tissue specific Intensity":{"lymphoid tissue":"26446.0"},"Antibody":["HPA060646","HPA077614"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":29,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA060646":null,"HPA077614":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.90e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":98,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB000114":null,"HPA020626":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":27,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"CAB009575":null,"HPA008873":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.37e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.98e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.74e-13"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.26e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.08e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.65e-6"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"}},{"Gene":"CCNE1","Gene synonym":["CCNE"],"Ensembl":"ENSG00000105173","Gene description":"Cyclin E1","Uniprot":["P24864"],"Chromosome":"19","Position":"29811991-29824312","Protein class":["Cancer-related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":["Cyclin"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"33.7","placenta":"29.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Extravillous trophoblasts":"2489.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Trophoblast cells":"2489.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Mitotic cells (Lung)","Prostate - Smooth muscle cells","Spleen - Mitotic cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB000308","CAB016682","HPA018169"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":54,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB000308":null,"CAB016682":null,"HPA018169":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.68e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.84e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.76e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.63e-5"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"}},{"Gene":"CCNH","Gene synonym":["CycH","p34","p37"],"Ensembl":"ENSG00000134480","Gene description":"Cyclin H","Uniprot":["P51946"],"Chromosome":"5","Position":"87318416-87412930","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Transcription","Transcription regulation"],"Molecular function":["Cyclin"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"1358.8","Vascular smooth muscle cells":"887.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":80,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB019416":null,"HPA044138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.18e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.26e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"}},{"Gene":"CCNK","Gene synonym":["CPR4"],"Ensembl":"ENSG00000090061","Gene description":"Cyclin K","Uniprot":["O75909"],"Chromosome":"14","Position":"99481169-99535044","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Host-virus interaction","Mitosis","Transcription","Transcription regulation"],"Molecular function":["Cyclin"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"96.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"432.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"432.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":24,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000645":null,"HPA077073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.98e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.52e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.50e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"CCNO","Gene synonym":["CCNU","FLJ22422","UDG2","UNG2"],"Ensembl":"ENSG00000152669","Gene description":"Cyclin O","Uniprot":["P22674"],"Chromosome":"5","Position":"55231152-55233608","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Cilium biogenesis\/degradation"],"Molecular function":["Cyclin"],"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"10.2","pancreas":"11.3","testis":"12.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Respiratory deuterosomal cells":"995.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"995.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"66.5","ependymal cell":"20.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"25.0"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"25.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"39","Protein cell type specific Intensity":{"Fallopian tube cells":"3922.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA050090","HPA076641"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Centriolar satellite"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":4,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"HPA050090":null,"HPA076641":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.52e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-3"}},{"Gene":"CCNT1","Gene synonym":["CCNT","CYCT1","HIVE1"],"Ensembl":"ENSG00000129315","Gene description":"Cyclin T1","Uniprot":["O60563"],"Chromosome":"12","Position":"48688458-48716998","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":["Cyclin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"171.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"727799.2","Granulosa cells":"243379.6","Neurons":"354154.7","T-cells":"552488.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7581","Protein tissue specific Intensity":{"lymphoid tissue":"758096.2"},"Antibody":["HPA004892","CAB009016","HPA072012"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":54,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB009016":null,"HPA004892":null,"HPA072012":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.59e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"}},{"Gene":"CCPG1","Gene synonym":["CPR8","KIAA1254"],"Ensembl":"ENSG00000260916","Gene description":"Cell cycle progression 1","Uniprot":["Q9ULG6"],"Chromosome":"15","Position":"55340032-55408510","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"258.9","Brain inhibitory neurons":"260.9","Choroid plexus epithelial cells":"113.3","Ependymal cells":"119.6","Loop of henle epithelial cells":"107.7","Neutrophil progenitors":"139.8","Neutrophils":"125.7","Other brain neurons":"220.8","Podocytes":"101.7","Renal collecting duct intercalated cells":"168.4","Renal collecting duct principal cells":"141.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"119.6","Ductal cells":"168.4","Neuronal cells":"260.9","Neutrophils":"139.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"280.3","neutrophil":"298.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"298.2","monocytes":"84.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Skin - Endothelial cells","Stomach - Chief cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"1408991.4","Neutrophils":"3351614.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"646659.3"},"Antibody":["HPA009432","HPA026861"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":5,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA009432":null,"HPA026861":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.35e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"}},{"Gene":"CCR6","Gene synonym":["BN-1","CD196","CKR-L3","CMKBR6","DCR2","DRY-6","GPR-CY4","GPR29","STRL22"],"Ensembl":"ENSG00000112486","Gene description":"C-C motif chemokine receptor 6","Uniprot":["P51684"],"Chromosome":"6","Position":"167111807-167139141","Protein class":["CD markers","G-protein coupled receptors","Human disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"lymphoid tissue":"31.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1.2","B-cells":"5.8","Brain excitatory neurons":"2.1","Brain inhibitory neurons":"2.3","Distal convoluted tubule cells":"2.2","Ependymal cells":"6.6","Foveolar cells":"1.8","Innate lymphoid cells":"1.8","Loop of henle epithelial cells":"2.0","Other brain neurons":"2.1","Papillary tip epithelial cells":"1.5","Podocytes":"1.8","Proximal tubule cells":"2.6","Renal collecting duct intercalated cells":"1.5","Renal collecting duct principal cells":"2.4","Renal connecting tubule cells":"1.2","T-cells":"3.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"5.8","Ciliated cells":"6.6","Ductal cells":"2.4","Neuronal cells":"2.3","Renal nephron cells":"2.6","T-cells":"3.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"26.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"MAIT T-cell":"70.3","memory B-cell":"64.1","memory CD4 T-cell":"27.4","naive B-cell":"73.4","T-reg":"52.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"73.4","T-cells":"70.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"5.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Lung - T-cells","Prostate - T-cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"7","RNA mouse brain regional specific nTPM":{"basal ganglia":"1.8"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"241612.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB006820","HPA014488"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB006820":null,"HPA014488":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.30e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.48e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CCSER2","Gene synonym":["FAM190B","KIAA1128"],"Ensembl":"ENSG00000107771","Gene description":"Coiled-coil serine rich protein 2","Uniprot":["Q9H7U1"],"Chromosome":"10","Position":"84328586-84518521","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"13","RNA single cell type specific nCPM":{"Early spermatids":"2729.8","Late spermatids":"8992.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"8992.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"112","Protein cell type specific Intensity":{"T-cells":"11246.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037481","HPA037482"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":14,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA037481":null,"HPA037482":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.71e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.20e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"}},{"Gene":"CCT2","Gene synonym":["Cctb"],"Ensembl":"ENSG00000166226","Gene description":"Chaperonin containing TCP1 subunit 2","Uniprot":["P78371"],"Chromosome":"12","Position":"69585426-69601570","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1560.5","Late primary spermatocytes":"1325.4","Late spermatids":"576.2","Oocytes":"598.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1560.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003197","HPA003198"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol","Connecting piece","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3400000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":326,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Connecting piece","Mid piece","Principal piece"],"Antibody RRID":{"HPA003197":null,"HPA003198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.42e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.95e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":82,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042996":null,"HPA045576":null,"HPA049949":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.37e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.47e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"}},{"Gene":"CCT7","Gene synonym":["Ccth","Nip7-1"],"Ensembl":"ENSG00000135624","Gene description":"Chaperonin containing TCP1 subunit 7","Uniprot":["Q99832"],"Chromosome":"2","Position":"73233420-73253021","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"360.1","Late primary spermatocytes":"740.1","Late spermatids":"360.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"740.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4100000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":220,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.95e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.96e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.01e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - 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Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":5,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA008992":null,"HPA015723":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.81e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"}},{"Gene":"CD163L1","Gene synonym":["CD163B","M160","SCARI2","WC1"],"Ensembl":"ENSG00000177675","Gene description":"CD163 molecule like 1","Uniprot":["Q9NR16"],"Chromosome":"12","Position":"7346685-7479897","Protein class":["CD markers","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"20.6","lymphoid tissue":"30.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"83.3","Hofbauer cells":"136.1","Kupffer cells":"152.7","Macrophages":"218.0","monocytes":"34.8","Neutrophils":"163.8","Retinal ganglion cells":"69.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"218.0","Neuronal cells":"69.5","Neutrophils":"163.8","Secretory cells":"83.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"50.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":null,"Subcellular main location":["Centrosome","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA015663":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"}},{"Gene":"CD19","Gene synonym":[],"Ensembl":"ENSG00000177455","Gene description":"CD19 molecule","Uniprot":["P15391"],"Chromosome":"16","Position":"28931965-28939342","Protein class":["CD markers","Disease related genes","FDA approved drug targets","Human disease related genes","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"intestine":"31.2","lymphoid tissue":"70.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"83.9","Early primary spermatocytes":"7.7","Early spermatids":"21.4","Epicardial cells":"6.8","Epididymal efferent duct ciliated cells":"10.1","Late primary spermatocytes":"39.0","Late spermatids":"9.4","Plasma cells":"19.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"83.9","Plasma cells":"19.5","Spermatogenic cell types":"39.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1.0","endothelial cell":"1.2","leukocyte":"1.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"81","RNA blood cell specific nTPM":{"memory B-cell":"138.6","naive B-cell":"172.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"90","RNA blood lineage specific nTPM":{"B-cells":"172.5"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"13","RNA cell line specific nTPM":{"Leukemia":"37.8","lymphoma":"71.1"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB016110":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.75e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CD2","Gene synonym":["SRBC"],"Ensembl":"ENSG00000116824","Gene description":"CD2 molecule","Uniprot":["P06729"],"Chromosome":"1","Position":"116754430-116769229","Protein class":["CD markers","FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"lymphoid tissue":"232.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Innate lymphoid cells":"131.5","NK-cells":"142.3","T-cells":"525.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Innate lymphoid cells":"131.5","NK-cells":"142.3","T-cells":"525.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"242","RNA single nuclei brain specific nCPM":{"leukocyte":"345.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"gdT-cell":"422.7","MAIT T-cell":"403.9","memory CD4 T-cell":"611.9","memory CD8 T-cell":"713.9","naive CD4 T-cell":"317.2","naive CD8 T-cell":"487.5","NK-cell":"1110.8","T-reg":"656.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"NK-cells":"1110.8","T-cells":"713.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"66","RNA cell line specific nTPM":{"Leukemia":"11.8","lymphoma":"12.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":15,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus"],"Antibody RRID":{"CAB002430":null,"HPA003883":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CD207","Gene synonym":["CLEC4K","Langerin"],"Ensembl":"ENSG00000116031","Gene description":"CD207 molecule","Uniprot":["Q9UJ71"],"Chromosome":"2","Position":"70830211-70835816","Protein class":["CD markers","Disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skin 1":"82.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"cDC":"6.8","Macrophages":"16.2","Retinal pigment epithelial cells":"4.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"dendritic cells":"6.8","Mononuclear phagocytes":"16.2","Pigment cells":"4.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"10.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"myeloid DC":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"dendritic cells":"1.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.3"},"RNA tissue cell type enrichment":["Testis - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"CD320","Gene synonym":["8D6","8D6A","TCblR"],"Ensembl":"ENSG00000167775","Gene description":"CD320 molecule","Uniprot":["Q9NPF0"],"Chromosome":"19","Position":"8302127-8308358","Protein class":["CD markers","Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"582.4","Late primary spermatocytes":"194.9","Vascular endothelial cells":"188.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"582.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"endothelial cell":"323.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014500","HPA014522"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"95000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA014500":null,"HPA014522":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.47e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.73e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"CD48","Gene synonym":["BCM1","BLAST","hCD48","mCD48","SLAMF2"],"Ensembl":"ENSG00000117091","Gene description":"CD48 molecule","Uniprot":["P09326"],"Chromosome":"1","Position":"160678746-160711831","Protein class":["CD markers","Plasma proteins","Predicted membrane proteins","Predicted secreted proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"140.1","lymphoid tissue":"265.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"302.7","cDC":"190.7","Innate lymphoid cells":"122.2","Kupffer cells":"115.8","Macrophages":"82.6","Mast cells":"186.6","Monocyte progenitors":"76.8","monocytes":"316.6","Neutrophils":"294.5","NK-cells":"216.7","Plasma cells":"189.4","T-cells":"310.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"302.7","dendritic cells":"190.7","Mast cells":"186.6","Mononuclear phagocytes":"316.6","Neutrophils":"294.5","NK-cells":"216.7","Plasma cells":"189.4","T-cells":"310.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"144","RNA single nuclei brain specific nCPM":{"leukocyte":"159.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"243.2","Myeloma":"458.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Breast - T-cells","Pituitary gland - T-cells","Prostate - T-cells","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"1219669.0","Neutrophils":"1196082.7","T-cells":"2657932.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"30895551.3"},"Antibody":["CAB002497","HPA055146"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Plasma membrane","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":1770000,"Blood concentration - Conc. blood MS [pg\/L]":"1000000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoli fibrillar center","Cytosol"],"Antibody RRID":{"CAB002497":null,"HPA055146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.81e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"}},{"Gene":"CD55","Gene synonym":["CR","CROM","DAF","TC"],"Ensembl":"ENSG00000196352","Gene description":"CD55 molecule (Cromer blood group)","Uniprot":["P08174"],"Chromosome":"1","Position":"207321519-207386804","Protein class":["Blood group antigen proteins","CD markers","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Complement pathway","Host-virus interaction","Immunity","Innate immunity"],"Molecular function":["Blood group antigen","Host cell receptor for virus entry","Receptor"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"2487.6","Epicardial cells":"1903.5","Esophageal apical cells":"1430.3","Neutrophils":"7705.1","Ocular epithelial cells":"1980.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"7705.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"199.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"653.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 1","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"2225655.5","Smooth muscle cells":"3486852.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"44003355.9"},"Antibody":["HPA002190","CAB010454","HPA024386"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Complement pathway","CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":32300000,"Blood concentration - Conc. blood MS [pg\/L]":"16000000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB010454":null,"HPA002190":null,"HPA024386":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.47e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.72e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"}},{"Gene":"CDADC1","Gene synonym":["NYD-SP15"],"Ensembl":"ENSG00000102543","Gene description":"Cytidine and dCMP deaminase domain containing 1","Uniprot":["Q9BWV3"],"Chromosome":"13","Position":"49247925-49293485","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"232.3","Hematopoietic stem cells":"208.6","Neutrophil progenitors":"483.9","Neutrophils":"450.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"483.9","Spermatogenic cell types":"232.3","Stem cells":"208.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"9.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"9.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047615":null,"HPA058314":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.04e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.02e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"}},{"Gene":"CDC14A","Gene synonym":["cdc14","Cdc14A1","Cdc14A2","DFNB105","DFNB32"],"Ensembl":"ENSG00000079335","Gene description":"Cell division cycle 14A","Uniprot":["Q9UNH5"],"Chromosome":"1","Position":"100345001-100520277","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Hearing"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"24.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Innate lymphoid cells":"730.7","Podocytes":"1893.4","T-cells":"544.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Innate lymphoid cells":"730.7","Renal nephron cells":"1893.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"217.9","endothelial cell":"254.0","leukocyte":"300.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"18.9"},"RNA tissue cell type enrichment":["Kidney - Podocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"6449","Protein cell type specific Intensity":{"Fallopian tube cells":"502479.3","Glomeruli":"787221.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"8352","Protein tissue specific Intensity":{"fallopian tube":"835152.1"},"Antibody":["HPA023783"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":12,"Subcellular main location":["Nucleoplasm","Endoplasmic reticulum"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023783":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.36e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"}},{"Gene":"CDC14C","Gene synonym":["CDC14B2","CDC14Bretro","CDC14CP","MGC26484"],"Ensembl":"ENSG00000218305","Gene description":"Cell division cycle 14C","Uniprot":["A4D256"],"Chromosome":"7","Position":"48924547-48927454","Protein class":["Enzymes","Essential proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"retina":"4.1","testis":"7.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"46.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"467","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"46.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - 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Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1744","Protein cell type specific Intensity":{"Granulosa cells":"174394.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004525","HPA045842","HPA055288"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":123,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB004525":null,"HPA045842":null,"HPA055288":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.74e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.80e-14"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.16e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.85e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.66e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.25e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.76e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.85e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.75e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"}},{"Gene":"CDC20B","Gene synonym":["FLJ37927"],"Ensembl":"ENSG00000164287","Gene description":"Cell division cycle 20B","Uniprot":["Q86Y33"],"Chromosome":"5","Position":"55112971-55173177","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"1.9","kidney":"1.0","testis":"2.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"55","RNA single cell type specific nCPM":{"Respiratory deuterosomal cells":"3831.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"55","RNA single cell type group specific nCPM":{"Ciliated cells":"3831.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"7.3","ependymal cell":"4.3","fibroblast":"6.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"8.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Esophageal cancer":"1.1"},"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"405","Protein cell type specific Intensity":{"Fallopian tube cells":"40527.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"160","Protein tissue specific Intensity":{"fallopian tube":"16000.6"},"Antibody":["HPA053900"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053900":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"CDC25A","Gene synonym":[],"Ensembl":"ENSG00000164045","Gene description":"Cell division cycle 25A","Uniprot":["P30304"],"Chromosome":"3","Position":"48157146-48188417","Protein class":["Cancer-related genes","Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"14.4","lymphoid tissue":"8.2","testis":"12.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"20.8","Early primary spermatocytes":"16.4","Early spermatids":"19.5","Erythrocyte progenitors":"32.1","Late primary spermatocytes":"14.5","Late spermatids":"48.1","Megakaryocyte progenitors":"20.4","Monocyte progenitors":"16.0","Neutrophil progenitors":"11.2","Oocytes":"13.8","Undifferentiated spermatogonia":"12.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"32.1","Megakaryocytes":"20.4","Spermatogenic cell types":"48.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"31.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":44,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA005855":null,"HPA008803":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - 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Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1524","Protein cell type specific Intensity":{"Granulosa cells":"152391.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB003800","HPA066991"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":55,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB003800":null,"HPA066991":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.57e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.09e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.26e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.28e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"}},{"Gene":"CDC40","Gene synonym":["EHB3","FLJ10564","PRP17","PRPF17"],"Ensembl":"ENSG00000168438","Gene description":"Cell division cycle 40","Uniprot":["O60508"],"Chromosome":"6","Position":"110180141-110254275","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"315.9","Early spermatids":"368.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"315.9","Spermatogenic cell types":"368.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"10289860.1"},"Antibody":["HPA046620"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":59,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA046620":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.63e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"CDC42EP3","Gene synonym":["BORG2","CEP3","UB1"],"Ensembl":"ENSG00000163171","Gene description":"CDC42 effector protein 3","Uniprot":["Q9UKI2"],"Chromosome":"2","Position":"37641882-37738468","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell shape"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Mast cells":"314.0","Melanocytes":"563.7","Neutrophils":"1010.4","Podocytes":"296.3","Thymic myoid cells":"315.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1010.4","Pigment cells":"563.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"100.7","leukocyte":"104.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"202","Protein cell type specific Intensity":{"Glomeruli":"20231.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"50986.7"},"Antibody":["HPA034986","HPA061792"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Actin filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":4,"Subcellular main location":["Plasma membrane","Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA034986":null,"HPA061792":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.20e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"}},{"Gene":"CDC45","Gene synonym":["CDC45L","CDC45L2"],"Ensembl":"ENSG00000093009","Gene description":"Cell division cycle 45","Uniprot":["O75419"],"Chromosome":"22","Position":"19479457-19520612","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","DNA replication"],"Molecular function":null,"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"24.0","lymphoid tissue":"19.0","testis":"26.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"56.9","Early primary spermatocytes":"116.0","Early spermatids":"132.2","Erythrocyte progenitors":"67.5","Extravillous trophoblasts":"27.8","Late primary spermatocytes":"109.2","Megakaryocyte progenitors":"40.1","Monocyte progenitors":"27.9","Oocytes":"50.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"67.5","Megakaryocytes":"40.1","Oocytes":"50.7","Spermatogenic cell types":"132.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"endothelial cell":"4.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2536","Protein cell type specific Intensity":{"Granulosa cells":"320272.5","Neutrophils":"186887.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA000614","CAB009459"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":58,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"CAB009459":null,"HPA000614":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.90e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.14e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"CDC7","Gene synonym":["CDC7L1","HsCdc7","Hsk1","huCdc7"],"Ensembl":"ENSG00000097046","Gene description":"Cell division cycle 7","Uniprot":["O00311"],"Chromosome":"1","Position":"91500851-91525764","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"15.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Breast lactating cells":"298.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Secretory cells":"298.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in all","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Gallbladder cancer":"199.8"},"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 4: Breast lactating luminal cells - Lactation","Interactions":55,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle"],"Antibody RRID":{"CAB002669":null,"HPA035831":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.00e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.45e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.09e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.14e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"}},{"Gene":"CDCA2","Gene synonym":["PPP1R81","Repo-Man"],"Ensembl":"ENSG00000184661","Gene description":"Cell division cycle associated 2","Uniprot":["Q69YH5"],"Chromosome":"8","Position":"25459199-25507911","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"6.1","lymphoid tissue":"10.6","testis":"18.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"37.3","Differentiating spermatogonia":"52.2","Early primary spermatocytes":"53.5","Early spermatids":"39.2","Erythrocyte progenitors":"64.4","Extravillous trophoblasts":"29.8","Late primary spermatocytes":"108.7","Late spermatids":"32.5","Megakaryocyte progenitors":"40.2","Monocyte progenitors":"73.7","Neutrophil progenitors":"31.3","Undifferentiated spermatogonia":"40.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"64.4","Mononuclear phagocytes":"73.7","Spermatogenic cell types":"108.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"3.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"670","Protein cell type specific Intensity":{"Granulosa cells":"67045.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"57","Protein tissue specific Intensity":{"bone marrow":"5719.8"},"Antibody":["HPA026293","HPA030049"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA026293":null,"HPA030049":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.85e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.97e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"}},{"Gene":"CDCA3","Gene synonym":["GRCC8","TOME-1"],"Ensembl":"ENSG00000111665","Gene description":"Cell division cycle associated 3","Uniprot":["Q99618"],"Chromosome":"12","Position":"6844793-6851292","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"28.4","retina":"61.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"68.4","Cytotrophoblasts":"32.5","Early primary spermatocytes":"42.2","Enteric transient amplifying cells":"49.1","Enterocytes":"60.2","Erythrocyte progenitors":"31.5","Esophageal basal cells":"36.8","Extravillous trophoblasts":"84.3","Gastric progenitor cells":"28.2","Hofbauer cells":"29.8","Late primary spermatocytes":"92.6","Megakaryocyte progenitors":"30.1","Migrating cytotrophoblasts":"52.2","Monocyte progenitors":"39.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"60.2","Myocytes":"68.4","Proliferating cells":"49.1","Spermatogenic cell types":"92.6","Trophoblast cells":"84.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"4.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Lung - Mitotic cells (Lung)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"171","Protein cell type specific Intensity":{"Granulosa cells":"17068.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"73","Protein tissue specific Intensity":{"bone marrow":"7309.0"},"Antibody":["HPA026587"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA026587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.03e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.06e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.75e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.09e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.08e-10"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"}},{"Gene":"CDCA5","Gene synonym":[],"Ensembl":"ENSG00000146670","Gene description":"Cell division cycle associated 5","Uniprot":["Q96FF9"],"Chromosome":"11","Position":"65066300-65084164","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"50.4","lymphoid tissue":"25.7","testis":"37.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"48.2","Early primary spermatocytes":"36.3","Early spermatids":"49.1","Erythrocyte progenitors":"47.5","Esophageal basal cells":"31.1","Extravillous trophoblasts":"46.9","Late primary spermatocytes":"103.7","Late spermatids":"208.1","Megakaryocyte progenitors":"38.3","Migrating cytotrophoblasts":"45.4","Monocyte progenitors":"59.4","Neutrophil progenitors":"28.2","Oocytes":"32.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"47.5","Mononuclear phagocytes":"59.4","Spermatogenic cell types":"208.1","Trophoblast cells":"46.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"NK-cell":"2.8","T-reg":"2.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"NK-cells":"2.8","T-cells":"2.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"white matter":"1.4"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2042","Protein cell type specific Intensity":{"Granulosa cells":"204236.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"143","Protein tissue specific Intensity":{"bone marrow":"14323.7"},"Antibody":["HPA023691","HPA076007"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA023691":null,"HPA076007":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.23e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.34e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.12e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.37e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.12e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.36e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.41e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"}},{"Gene":"CDH10","Gene synonym":[],"Ensembl":"ENSG00000040731","Gene description":"Cadherin 10","Uniprot":["Q9Y6N8"],"Chromosome":"5","Position":"24487100-24644978","Protein class":["Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"18.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"230.6","Bergmann glia":"829.3","Brain excitatory neurons":"361.2","Brain inhibitory neurons":"224.1","Oligodendrocyte progenitor cells":"618.8","Other brain neurons":"126.5","Pancreatic islet cells":"96.9","Retinal amacrine cells":"157.4","Retinal ganglion cells":"96.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Glial cells":"829.3","Neuronal cells":"361.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"7.1","testis cancer":"10.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"510000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":1,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA010651":null,"HPA012085":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA029325":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDH13","Gene synonym":["CDHH"],"Ensembl":"ENSG00000140945","Gene description":"Cadherin 13","Uniprot":["P55290"],"Chromosome":"16","Position":"82626965-83800640","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"140.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"363.9","Brain inhibitory neurons":"343.2","Cardiomyocytes":"1834.5","Myonuclei":"2264.9","Myosatellite cells":"612.5","Oligodendrocyte progenitor cells":"596.9","Salivary myoepithelial cells":"366.3","Thymic myoid cells":"1325.6","Vascular endothelial cells":"361.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"596.9","Myocytes":"2264.9","Stem cells":"612.5","Stromal cells":"1325.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"1191.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"35.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"4.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1.4","monocytes":"4.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"66.5","testis cancer":"95.3"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"160000000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":3,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB025863":null,"HPA001380":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.77e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.93e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.97e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014416":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDH22","Gene synonym":["C20orf25","dJ998H6.1"],"Ensembl":"ENSG00000149654","Gene description":"Cadherin 22","Uniprot":["Q9UJ99"],"Chromosome":"20","Position":"46173739-46308498","Protein class":["Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"brain":"44.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal prostatic cells":"28.6","Brain excitatory neurons":"97.7","Brain inhibitory neurons":"36.3","Cone photoreceptor cells":"37.3","Corticotrophs":"55.5","Early spermatids":"91.6","Late primary spermatocytes":"30.7","Late spermatids":"54.8","Pancreatic islet cells":"29.3","Respiratory ionocytes":"45.7","Retinal amacrine cells":"48.8","Retinal bipolar cells":"26.0","Salivary ionocytes":"77.1","Thymic myoid cells":"54.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ionocytes":"77.1","Neuronal cells":"97.7","Pituitary endocrine cells":"55.5","Spermatogenic cell types":"91.6","Stromal cells":"54.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"197.5","upper rhombic lip":"203.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"1.1"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA012164":null,"HPA012715":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.74e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDHR4","Gene synonym":["CDH29","VLLR9392"],"Ensembl":"ENSG00000187492","Gene description":"Cadherin related family member 4","Uniprot":["A6H8M9"],"Chromosome":"3","Position":"49790732-49799873","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"fallopian tube":"55.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"160.0","Epididymal efferent duct ciliated cells":"197.3","Fallopian tube ciliated cells":"180.1","Respiratory ciliated cells":"253.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Ciliated cells":"253.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"101","RNA single nuclei brain specific nCPM":{"ependymal cell":"40.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"17.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"classical monocyte":"2.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA076277":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"}},{"Gene":"CDIN1","Gene synonym":["C15orf41","FLJ22851","HH114","MGC11326"],"Ensembl":"ENSG00000186073","Gene description":"CDAN1 interacting nuclease 1","Uniprot":["Q9Y2V0"],"Chromosome":"15","Position":"36579626-36810248","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Congenital dyserythropoietic anemia","Disease variant","Hereditary hemolytic anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"heart muscle":"73.6","tongue":"32.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"1644.5","Myonuclei":"292.3","Thymic myoid cells":"422.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"1644.5","Stromal cells":"422.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"303919.8","Granulosa cells":"239679.4","Oocytes":"484522.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA061023"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA061023":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.97e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.10e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.78e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"CDK1","Gene synonym":["CDC2","CDC28A"],"Ensembl":"ENSG00000170312","Gene description":"Cyclin dependent kinase 1","Uniprot":["P06493"],"Chromosome":"10","Position":"60778331-60794852","Protein class":["Cancer-related genes","Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Apoptosis","Biological rhythms","Cell cycle","Cell division","Host-virus interaction","Mitosis"],"Molecular function":["Host cell receptor for virus entry","Kinase","Receptor","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"50.2","lymphoid tissue":"68.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"83.8","Differentiating spermatogonia":"65.2","Early primary spermatocytes":"67.7","Enteric transient amplifying cells":"76.4","Erythrocyte progenitors":"125.8","Esophageal basal cells":"88.1","Extravillous trophoblasts":"161.3","Gastric progenitor cells":"144.8","Hofbauer cells":"97.9","Late primary spermatocytes":"189.7","Megakaryocyte progenitors":"97.8","Migrating cytotrophoblasts":"143.4","Monocyte progenitors":"159.0","Oocytes":"138.2","Respiratory deuterosomal cells":"70.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"125.8","Mononuclear phagocytes":"159.0","Oocytes":"138.2","Proliferating cells":"144.8","Spermatogenic cell types":"189.7","Trophoblast cells":"161.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"endothelial cell":"4.4","leukocyte":"1.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"3.3","T-reg":"3.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Pituitary gland - Somatotropes","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"6898809.4","Neutrophils":"6404364.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"19428643.9","intestine":"7026052.0"},"Antibody":["HPA003387","CAB003799","CAB079974"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol","Acrosome","Perinuclear theca","Connecting piece","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"44000","Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":168,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Acrosome","Perinuclear theca","Connecting piece","Flagellar centriole"],"Antibody RRID":{"CAB003799":null,"CAB079974":null,"HPA003387":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.73e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.67e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.02e-13"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.85e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.81e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.06e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"}},{"Gene":"CDK14","Gene synonym":["PFTAIRE1","PFTK1"],"Ensembl":"ENSG00000058091","Gene description":"Cyclin dependent kinase 14","Uniprot":["O94921"],"Chromosome":"7","Position":"90466424-91210590","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Wnt signaling pathway"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"796.5","Mesothelial cells":"719.4","Neutrophil progenitors":"725.7","Neutrophils":"1014.8","Plasma cells":"738.2","Retinal horizontal cells":"1302.2","Somatotrophs":"713.1","Transitional alveolar cells":"785.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"1302.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"basophil":"9.1","memory B-cell":"8.5","naive B-cell":"4.8","neutrophil":"4.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"B-cells":"8.5","granulocytes":"9.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"4595774.2","Neurons":"3078428.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"3302521.2","lymphoid tissue":"1550685.3"},"Antibody":["HPA015267"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":27,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA015267":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.99e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":7,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA015786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDK19","Gene synonym":["bA346C16.3","CDC2L6","CDK11","KIAA1028"],"Ensembl":"ENSG00000155111","Gene description":"Cyclin dependent kinase 19","Uniprot":["Q9BWU1"],"Chromosome":"6","Position":"110609978-110815958","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"473.1","Neutrophils":"820.7","Oligodendrocytes":"726.4","Prostatic glandular cells":"598.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"598.1","Glial cells":"726.4","Neutrophils":"820.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"951.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"39.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"4.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":108,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA007053":null,"HPA007062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.76e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.40e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.52e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.55e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"}},{"Gene":"CDK20","Gene synonym":["CCRK","p42","PNQALRE"],"Ensembl":"ENSG00000156345","Gene description":"Cyclin dependent kinase 20","Uniprot":["Q8IZL9"],"Chromosome":"9","Position":"87966441-87974753","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":["Developmental protein","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"19.0","Fallopian tube ciliated cells":"23.5","Late primary spermatocytes":"45.5","Oocytes":"18.4","Respiratory ciliated cells":"18.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"23.5","Spermatogenic cell types":"45.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"3.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"NK-cells":"3.6","T-cells":"2.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Connecting piece","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA007666":null,"HPA027379":null,"HPA027401":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.86e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.86e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.91e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"}},{"Gene":"CDK5R1","Gene synonym":["Nck5a","p35","p35nck5a"],"Ensembl":"ENSG00000176749","Gene description":"Cyclin dependent kinase 5 regulatory subunit 1","Uniprot":["Q15078"],"Chromosome":"17","Position":"32486993-32491253","Protein class":["Predicted intracellular proteins"],"Biological process":["Biological rhythms"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"71.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"42.5","Brain inhibitory neurons":"42.9","Cone photoreceptor cells":"16.6","Early spermatids":"21.4","Esophageal apical cells":"27.0","Late spermatids":"26.2","M\u00fcller glia":"15.7","Other brain neurons":"42.1","Retinal amacrine cells":"34.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"27.0","Neuronal cells":"42.9","Spermatogenic cell types":"26.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"23.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Skin - Keratinocyte (granular)","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"89324.7","Neurons":"234892.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3354","Protein tissue specific Intensity":{"cerebral cortex":"335423.2"},"Antibody":["HPA000252"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA000252":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.66e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.39e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"}},{"Gene":"CDK5RAP2","Gene synonym":["C48","CEP215","FLJ10867","MCPH3"],"Ensembl":"ENSG00000136861","Gene description":"CDK5 regulatory subunit associated protein 2","Uniprot":["Q96SN8"],"Chromosome":"9","Position":"120388875-120580170","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Calmodulin-binding"],"Disease involvement":["Intellectual disability","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"345.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"554242.5","Fallopian tube cells":"751927.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2672","Protein tissue specific Intensity":{"bone marrow":"267237.5"},"Antibody":["HPA035820","HPA035821","HPA046529","CAB079753"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cell Junctions","Centrosome","Basal body","Cytosol","Equatorial segment","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":35,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Cell Junctions","Cytosol","Equatorial segment","Mid piece","Principal piece"],"Antibody RRID":{"CAB079753":null,"HPA035820":null,"HPA035821":null,"HPA046529":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"}},{"Gene":"CDK7","Gene synonym":["CAK","CAK1","CDKN7","MO15","STK1"],"Ensembl":"ENSG00000134058","Gene description":"Cyclin dependent kinase 7","Uniprot":["P50613"],"Chromosome":"5","Position":"69234795-69277430","Protein class":["Cancer-related genes","Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA repair","Transcription","Transcription regulation"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"108.7","Esophageal apical cells":"142.4","Extravillous trophoblasts":"381.0","Late primary spermatocytes":"101.0","Migrating cytotrophoblasts":"171.8","Oocytes":"175.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"142.4","Oocytes":"175.0","Spermatogenic cell types":"101.0","Trophoblast cells":"381.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"3798446.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1119343.0"},"Antibody":["CAB004364","HPA007932","HPA008453","CAB079975"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":96,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Plasma membrane","Cytosol"],"Antibody RRID":{"CAB004364":null,"CAB079975":null,"HPA007932":null,"HPA008453":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.61e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":84,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044721":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.53e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA040672":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.27e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDKL3","Gene synonym":["NKIAMRE"],"Ensembl":"ENSG00000006837","Gene description":"Cyclin dependent kinase like 3","Uniprot":["Q8IVW4"],"Chromosome":"5","Position":"134286350-134371047","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"13.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"33.6","Early spermatids":"105.1","Late primary spermatocytes":"53.6","Late spermatids":"170.0","Loop of henle epithelial cells":"47.2","Papillary tip epithelial cells":"27.2","Podocytes":"57.0","Proximal tubule cells":"37.4","Renal collecting duct intercalated cells":"18.2","Renal collecting duct principal cells":"32.3","Renal connecting tubule cells":"35.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"35.4","Renal nephron cells":"57.0","Spermatogenic cell types":"170.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":23,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA027751":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA067895":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.52e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDKN2A","Gene synonym":["ARF","CDK4I","CDKN2","CMM2","INK4","INK4a","MLM","MTS1","p14","p14ARF","p16","P16-INK4A","p16INK4a","p19","p19Arf"],"Ensembl":"ENSG00000147889","Gene description":"Cyclin dependent kinase inhibitor 2A","Uniprot":["P42771","Q8N726"],"Chromosome":"9","Position":"21967752-21995301","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis","Cell cycle","rRNA processing","Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","Li-Fraumeni syndrome","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"42.5","pituitary gland":"35.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"202.4","Endometrial ciliated cells":"94.1","Gastric progenitor cells":"511.4","Late primary spermatocytes":"158.1","Late spermatids":"681.3","Somatotrophs":"86.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Proliferating cells":"511.4","Spermatogenic cell types":"681.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"28.1","choroid plexus epithelial cell":"63.1","leukocyte":"20.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"355.6","Ovary Serous Cystadenocarcinoma (TCGA)":"419.0"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"57.4"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"37.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"15.7","T-cells":"37.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"497.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":125,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Primary cilium tip","Primary cilium transition zone","Cytosol"],"Antibody RRID":{"CAB000093":null,"CAB000445":null,"CAB018232":null,"HPA073143":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.16e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.98e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"}},{"Gene":"CDKN2AIP","Gene synonym":["CARF","FLJ20036"],"Ensembl":"ENSG00000168564","Gene description":"CDKN2A interacting protein","Uniprot":["Q9NXV6"],"Chromosome":"4","Position":"183444635-183449064","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"185.5","Endometrial ciliated cells":"174.1","Endometrial glandular cells":"301.0","Endometrial luminal cells":"409.9","Esophageal apical cells":"166.8","Ocular epithelial cells":"160.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"301.0","Luminal cells":"409.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":23,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA041397":null,"HPA062142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.17e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"}},{"Gene":"CDKN2B","Gene synonym":["CDK4I","INK4B","MTS2","P15","p15INK4b","TP15"],"Ensembl":"ENSG00000147883","Gene description":"Cyclin dependent kinase inhibitor 2B","Uniprot":["P42772"],"Chromosome":"9","Position":"22002903-22009305","Protein class":["Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"37.2","intestine":"29.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"107.3","Colonocytes":"232.6","Enterocytes":"201.6","Esophageal apical cells":"558.1","Esophageal suprabasal cells":"283.8","Ocular epithelial cells":"270.2","Suprabasal keratinocytes":"125.7","Urothelial cells":"185.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"558.1","Barrier epithelial cells":"270.2","Enterocytes":"232.6","Suprabasal cells":"283.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"11.5","endothelial cell":"5.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"46.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"classical monocyte":"3.3","intermediate monocyte":"3.3","non-classical monocyte":"9.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"monocytes":"9.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"457","Protein tissue specific Intensity":{"lung":"45672.1"},"Antibody":["CAB000349","HPA052838","HPA063327","HPA073143"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium","Primary cilium tip","Primary cilium transition zone","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":26,"Subcellular main location":["Nucleoplasm","Primary cilium transition zone"],"Subcellular additional location":["Primary cilium","Primary cilium tip","Cytosol"],"Antibody RRID":{"CAB000349":null,"HPA052838":null,"HPA063327":null,"HPA073143":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.92e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.84e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"}},{"Gene":"CDKN2D","Gene synonym":["INK4D","p19"],"Ensembl":"ENSG00000129355","Gene description":"Cyclin dependent kinase inhibitor 2D","Uniprot":["P55273"],"Chromosome":"19","Position":"10566460-10569059","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"267.8","brain":"127.7","lymphoid tissue":"72.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Megakaryocytes":"2262.5","Neutrophil progenitors":"222.0","Neutrophils":"560.8","Platelets":"1542.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"2262.5","Neutrophils":"560.8","Platelets":"1542.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Heart muscle - Macrophages","Liver - Neutrophils","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"488539.7","Neurons":"894304.8","Neutrophils":"890060.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"24125268.3"},"Antibody":["CAB011201","HPA043546"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":49,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB011201":null,"HPA043546":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.48e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"}},{"Gene":"CDKN3","Gene synonym":["CDI1","KAP"],"Ensembl":"ENSG00000100526","Gene description":"Cyclin dependent kinase inhibitor 3","Uniprot":["Q16667"],"Chromosome":"14","Position":"54396849-54420218","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"192.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Early spermatids":"2828.2","Late primary spermatocytes":"2256.0","Late spermatids":"791.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2828.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"19.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"NK-cells":"6.2","T-cells":"19.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB005285","HPA039311","HPA058874"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":12,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB005285":null,"HPA039311":null,"HPA058874":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.33e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.95e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.62e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.73e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.42e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.62e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"}},{"Gene":"CDNF","Gene synonym":["ARMETL1"],"Ensembl":"ENSG00000185267","Gene description":"Cerebral dopamine neurotrophic factor","Uniprot":["Q49AH0"],"Chromosome":"10","Position":"14819245-14838575","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"24.2","tongue":"19.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"476.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"476.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"17.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"270241.1","Oocytes":"518391.5","Pancreas epithelial cells":"188557.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"927847.4","skeletal muscle":"3390697.9"},"Antibody":["HPA044587"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Growth factor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CDR2","Gene synonym":["CDR62","Yo"],"Ensembl":"ENSG00000140743","Gene description":"Cerebellar degeneration related protein 2","Uniprot":["Q01850"],"Chromosome":"16","Position":"22345936-22437165","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"88.3","Brain inhibitory neurons":"153.6","Choroid plexus epithelial cells":"281.1","Distal convoluted tubule cells":"153.9","Loop of henle epithelial cells":"296.1","Papillary tip epithelial cells":"190.2","Podocytes":"124.4","Proximal tubule cells":"279.7","Renal collecting duct intercalated cells":"161.4","Renal collecting duct principal cells":"217.3","Renal connecting tubule cells":"177.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"281.1","Ductal cells":"217.3","Neuronal cells":"153.6","Renal nephron cells":"296.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"9.4","NK-cells":"4.3","T-cells":"6.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Fibroblasts","Minor Salivary Gland - Smooth muscle cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"946131.9","Oocytes":"557520.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018151","HPA023870"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 6: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":95,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA018151":null,"HPA023870":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"}},{"Gene":"CDRT15L2","Gene synonym":[],"Ensembl":"ENSG00000214819","Gene description":"CMT1A duplicated region transcript 15 like 2","Uniprot":["A8MXV6"],"Chromosome":"17","Position":"20579724-20580911","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"14.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"25","RNA single cell type specific nCPM":{"Early spermatids":"35.2","Late primary spermatocytes":"85.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"43","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"85.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"1.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"cerebral cortex":"1.4","hippocampal formation":"3.4"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CEBPG","Gene synonym":["GPE1BP","IG\/EBP-1"],"Ensembl":"ENSG00000153879","Gene description":"CCAAT enhancer binding protein gamma","Uniprot":["P53567"],"Chromosome":"19","Position":"33373685-33382686","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"177.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA012024":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.93e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"}},{"Gene":"CEBPZ","Gene synonym":["CBF2","CTF2"],"Ensembl":"ENSG00000115816","Gene description":"CCAAT enhancer binding protein zeta","Uniprot":["Q03701"],"Chromosome":"2","Position":"37201612-37231596","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"501.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"501.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":57,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA052065":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.55e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.26e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.28e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"}},{"Gene":"CELF3","Gene synonym":["BRUNOL1","CAGH4","ERDA4","MGC57297","TNRC4"],"Ensembl":"ENSG00000159409","Gene description":"CUGBP Elav-like family member 3","Uniprot":["Q5SZQ8"],"Chromosome":"1","Position":"151700058-151716803","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["Activator","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"99.3","pituitary gland":"104.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"74.5","Brain excitatory neurons":"31.4","Brain inhibitory neurons":"37.5","Cone photoreceptor cells":"43.5","Corticotrophs":"23.7","Gonadotrophs":"22.1","Lactotrophs":"86.0","Neuroendocrine cells":"54.6","Other brain neurons":"37.2","Pancreatic islet cells":"36.4","Retinal amacrine cells":"22.4","Retinal bipolar cells":"101.3","Somatotrophs":"39.2","Thyrotrophs":"53.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"74.5","Enteroendocrine cells":"54.6","Neuronal cells":"101.3","Pancreatic islet cells":"36.4","Pituitary endocrine cells":"86.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"11.2","Pancreatic Adenocarcinoma (TCGA)":"9.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Neuroblastoma":"66.0"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA006292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CELF4","Gene synonym":["BRUNOL4"],"Ensembl":"ENSG00000101489","Gene description":"CUGBP Elav-like family member 4","Uniprot":["Q9BZC1"],"Chromosome":"18","Position":"37243040-37565827","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["Activator","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"94.3","pituitary gland":"26.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"265.9","Brain excitatory neurons":"341.9","Brain inhibitory neurons":"367.3","Corticotrophs":"186.3","Lactotrophs":"271.7","Other brain neurons":"372.4","Retinal amacrine cells":"865.3","Retinal ganglion cells":"177.7","Retinal horizontal cells":"412.7","Somatotrophs":"367.0","Thyrotrophs":"279.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"265.9","Neuronal cells":"865.3","Pituitary endocrine cells":"367.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"7.9","Neuroblastoma":"14.3"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA013322":null,"HPA037986":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-5"}},{"Gene":"CENPF","Gene synonym":["hcp-1"],"Ensembl":"ENSG00000117724","Gene description":"Centromere protein F","Uniprot":["P49454"],"Chromosome":"1","Position":"214603185-214664574","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","DNA synthesis","Mitosis","Myogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Cancer-related genes","Ciliopathy","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"19.8","lymphoid tissue":"23.7","testis":"7.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"189.9","Enteric transient amplifying cells":"105.0","Erythrocyte progenitors":"597.7","Esophageal basal cells":"104.6","Late primary spermatocytes":"243.5","Megakaryocyte progenitors":"387.8","Monocyte progenitors":"507.8","Neutrophil progenitors":"166.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"597.7","Megakaryocytes":"387.8","Mononuclear phagocytes":"507.8","Spermatogenic cell types":"243.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"9.8","leukocyte":"6.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2600","Protein cell type specific Intensity":{"Granulosa cells":"361029.7","Pancreas epithelial cells":"193136.0","Pancreatic islets":"225714.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2071461.1","skeletal muscle":"2871457.1"},"Antibody":["HPA052382","HPA064308","CAB070134"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB070134":null,"HPA052382":null,"HPA064308":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.29e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.58e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.29e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.46e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.26e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.12e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.13e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"}},{"Gene":"CENPJ","Gene synonym":["BM032","CPAP","LAP","LIP1","MCPH6","Sas-4","SASS4","SCKL4"],"Ensembl":"ENSG00000151849","Gene description":"Centromere protein J","Uniprot":["Q9HC77"],"Chromosome":"13","Position":"24882279-24922889","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Dwarfism","Intellectual disability","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"15.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"80.1","Early spermatids":"230.2","Late primary spermatocytes":"59.7","Megakaryocyte progenitors":"134.0","Monocyte progenitors":"66.0","Oligodendrocytes":"62.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"134.0","Spermatogenic cell types":"230.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"237.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":60,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Acrosome"],"Antibody RRID":{"HPA076638":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.24e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"CENPL","Gene synonym":["C1orf155","dJ383J4.3","FLJ31044"],"Ensembl":"ENSG00000120334","Gene description":"Centromere protein L","Uniprot":["Q8N0S6"],"Chromosome":"1","Position":"173799550-173824883","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"8.9","testis":"9.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"45.8","Erythrocyte progenitors":"30.9","Monocyte progenitors":"33.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"45.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"2503614.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044520"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044520":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.55e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.95e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"}},{"Gene":"CENPM","Gene synonym":["C22orf18","CENP-M","MGC861","Pane1"],"Ensembl":"ENSG00000100162","Gene description":"Centromere protein M","Uniprot":["Q9NSP4"],"Chromosome":"22","Position":"41938737-41947152","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"27.4","lymphoid tissue":"23.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"118.5","Enteric transient amplifying cells":"86.6","Epididymal efferent duct ciliated cells":"157.4","Erythrocyte progenitors":"84.8","Esophageal basal cells":"72.7","Fallopian tube ciliated cells":"115.3","Hofbauer cells":"72.5","Megakaryocyte progenitors":"56.8","Migrating cytotrophoblasts":"56.2","Monocyte progenitors":"60.9","Respiratory ciliated cells":"87.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"157.4","Erythrocytes":"84.8","Proliferating cells":"86.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"51.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"38.8","T-cells":"51.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3544","Protein cell type specific Intensity":{"Granulosa cells":"354403.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042404"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042404":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.68e-6"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.03e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.08e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.97e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.56e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.48e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.01e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"}},{"Gene":"CENPN","Gene synonym":["BM039","C16orf60","FLJ13607","FLJ22660"],"Ensembl":"ENSG00000166451","Gene description":"Centromere protein N","Uniprot":["Q96H22"],"Chromosome":"16","Position":"81006552-81033114","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"35.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"58.6","Cytotrophoblasts":"57.4","Early primary spermatocytes":"66.5","Enteric transient amplifying cells":"57.3","Esophageal basal cells":"78.6","Extravillous trophoblasts":"111.0","Gastric progenitor cells":"91.0","Late primary spermatocytes":"55.0","Migrating cytotrophoblasts":"90.2","Prostatic glandular cells":"78.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"91.0","Trophoblast cells":"111.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"9.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate glandular cells","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2214","Protein cell type specific Intensity":{"Granulosa cells":"123544.3","Neutrophils":"319216.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052870"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA052870":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.54e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.38e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"}},{"Gene":"CENPS","Gene synonym":["APITD1","CENP-S","FAAP16","MHF1"],"Ensembl":"ENSG00000175279","Gene description":"Centromere protein S","Uniprot":["Q8N2Z9"],"Chromosome":"1","Position":"10430433-10442808","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA repair","Mitosis"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"46.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"8.1","Choroid plexus epithelial cells":"9.9","Early primary spermatocytes":"13.0","Early spermatids":"11.3","Ependymal cells":"15.3","Epididymal efferent duct ciliated cells":"9.7","Late primary spermatocytes":"29.6","Late spermatids":"24.6","Other brain neurons":"8.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"15.3","Spermatogenic cell types":"29.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"753488.0","Oocytes":"220898.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2023","Protein tissue specific Intensity":{"bone marrow":"202296.8"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":29,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.94e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.62e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.89e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.41e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"CENPU","Gene synonym":["CENP-50","CENP-U","KLIP1","MLF1IP","PBIP1"],"Ensembl":"ENSG00000151725","Gene description":"Centromere protein U","Uniprot":["Q71F23"],"Chromosome":"4","Position":"184694085-184734130","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"59.0","testis":"27.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"173.2","Early primary spermatocytes":"469.1","Early spermatids":"417.1","Erythrocyte progenitors":"230.2","Late primary spermatocytes":"809.4","Late spermatids":"1614.1","Neutrophils":"188.5","Oocytes":"239.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1614.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"6.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"20.7","eosinophil":"14.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"20.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"667632.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA022048"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centriolar satellite"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":27,"Subcellular main location":["Nucleoplasm","Centriolar satellite"],"Subcellular additional location":null,"Antibody RRID":{"HPA022048":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.51e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.25e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.35e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"}},{"Gene":"CENPW","Gene synonym":["C6orf173","CUG2"],"Ensembl":"ENSG00000203760","Gene description":"Centromere protein W","Uniprot":["Q5EE01"],"Chromosome":"6","Position":"126340115-126348875","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"47.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"242.6","Endometrial secretory cells":"106.0","Enteric transient amplifying cells":"119.5","Esophageal basal cells":"259.1","Extravillous trophoblasts":"183.2","Gastric progenitor cells":"276.8","Late primary spermatocytes":"499.4","Megakaryocytes":"111.3","Oocytes":"119.7","Submucosal glandular cells":"122.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"259.1","Proliferating cells":"276.8","Spermatogenic cell types":"499.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"17.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"175.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA067285":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.26e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.49e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.84e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.27e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.32e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"}},{"Gene":"CEP104","Gene synonym":["CFAP256","GlyBP","JBTS25","KIAA0562","ROC22","RP1-286D6.4"],"Ensembl":"ENSG00000116198","Gene description":"Centrosomal protein 104","Uniprot":["O60308"],"Chromosome":"1","Position":"3812086-3857396","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Intellectual disability","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"552.7","Late spermatids":"153.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"552.7","Spermatogenic cell types":"153.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"36678.6","Smooth muscle cells":"39048.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"88406.3"},"Antibody":["HPA010126"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.91e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.86e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"}},{"Gene":"CEP112","Gene synonym":["CCDC46","MGC33887"],"Ensembl":"ENSG00000154240","Gene description":"Centrosomal protein 112","Uniprot":["Q8N8E3"],"Chromosome":"17","Position":"65635537-66192133","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"43.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1527.4","Ependymal cells":"518.4","Lactotrophs":"504.6","Late spermatids":"2282.5","Rod photoreceptor cells":"1137.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"1137.5","Spermatogenic cell types":"2282.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"22.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Breast - Endothelial cells","Minor Salivary Gland - Endothelial cells","Prostate - Fibroblasts","Skin - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"4365047.6","Oocytes":"1594070.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA069724"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Midbody ring","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":15,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Midbody ring","Cytosol"],"Antibody RRID":{"HPA069724":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.65e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"}},{"Gene":"CEP126","Gene synonym":["KIAA1377"],"Ensembl":"ENSG00000110318","Gene description":"Centrosomal protein 126","Uniprot":["Q9P2H0"],"Chromosome":"11","Position":"101915010-102001062","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"39.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"397.0","Endometrial ciliated cells":"324.1","Ependymal cells":"836.5","Epididymal efferent duct ciliated cells":"385.7","Fallopian tube ciliated cells":"602.7","Lactotrophs":"308.8","Respiratory ciliated cells":"802.5","Somatotrophs":"690.5","Thyrotrophs":"684.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"836.5","Pituitary endocrine cells":"690.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"902.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.39e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"}},{"Gene":"CEP128","Gene synonym":["C14orf145","C14orf61"],"Ensembl":"ENSG00000100629","Gene description":"Centrosomal protein 128","Uniprot":["Q6ZU80"],"Chromosome":"14","Position":"80476983-80959517","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"23.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"208.7","Monocyte progenitors":"314.1","Myonuclei":"419.8","Neutrophil progenitors":"245.1","Plasma cells":"461.2","Respiratory ciliated cells":"222.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"314.1","Myocytes":"419.8","Plasma cells":"461.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"7.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"6.9","T-cells":"7.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"52.0"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"10014336.8","Pancreatic islets":"6322681.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"1379555.9"},"Antibody":["HPA001116","HPA005846","HPA018498"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":14,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA001116":null,"HPA005846":null,"HPA018498":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.89e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.74e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"}},{"Gene":"CEP135","Gene synonym":["CEP4","FLJ13621","KIAA0635"],"Ensembl":"ENSG00000174799","Gene description":"Centrosomal protein 135","Uniprot":["Q66GS9"],"Chromosome":"4","Position":"55948871-56033361","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"129.2","Late primary spermatocytes":"105.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"129.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"38865390.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"616675.5","fallopian tube":"1818077.5","lymphoid tissue":"1243618.5"},"Antibody":["HPA041539"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Acrosome","Mid piece","Principal piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":116,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":["Acrosome","Annulus"],"Antibody RRID":{"HPA041539":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"CEP152","Gene synonym":["KIAA0912","MCPH9","SCKL5"],"Ensembl":"ENSG00000103995","Gene description":"Centrosomal protein 152","Uniprot":["O94986"],"Chromosome":"15","Position":"48712928-48811146","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Disease variant","Dwarfism","Intellectual disability","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"15.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"311.5","Erythrocyte progenitors":"132.0","Late primary spermatocytes":"91.7","Monocyte progenitors":"116.1","Renal collecting duct intercalated cells":"104.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"311.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4767","Protein cell type specific Intensity":{"Collecting ducts":"476722.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5042","Protein tissue specific Intensity":{"skeletal muscle":"504171.0"},"Antibody":["HPA039408"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":27,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA039408":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.62e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.25e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"CEP162","Gene synonym":["C6orf84","KIAA1009","QN1"],"Ensembl":"ENSG00000135315","Gene description":"Centrosomal protein 162","Uniprot":["Q5TB80"],"Chromosome":"6","Position":"84124241-84227643","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"192.7","Ependymal cells":"172.6","Late primary spermatocytes":"187.7","Respiratory ciliated cells":"154.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"172.6","Spermatogenic cell types":"192.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"16964","Protein cell type specific Intensity":{"Fallopian tube cells":"1696357.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3771","Protein tissue specific Intensity":{"fallopian tube":"288883.0","heart muscle":"319966.0","intestine":"522420.0"},"Antibody":["HPA030170","HPA030171","HPA030172","HPA030173"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centriolar satellite","Basal body","Cytosol","Connecting piece","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":35,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Centriolar satellite","Basal body","Connecting piece","Mid piece","Principal piece"],"Antibody RRID":{"HPA030170":null,"HPA030171":null,"HPA030172":null,"HPA030173":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"CEP164","Gene synonym":["KIAA1052","NPHP15"],"Ensembl":"ENSG00000110274","Gene description":"Centrosomal protein 164","Uniprot":["Q9UPV0"],"Chromosome":"11","Position":"117314557-117413266","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Cilium biogenesis\/degradation","DNA damage","DNA repair","Mitosis"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Nephronophthisis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"623.1","Early spermatids":"342.9","Late spermatids":"441.4","Rod photoreceptor cells":"372.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"623.1","Spermatogenic cell types":"441.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"5842185.8","Fallopian tube cells":"2044841.3","Macrophages":"7368357.9","Neutrophils":"6856485.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"1437003.0"},"Antibody":["HPA037605","HPA037606","HPA061504"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Primary cilium transition zone","Centrosome","Equatorial segment","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":17,"Subcellular main location":["Primary cilium transition zone","Centrosome","Principal piece"],"Subcellular additional location":["Nucleoplasm","Vesicles","Equatorial segment"],"Antibody RRID":{"HPA037605":null,"HPA037606":null,"HPA061504":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.70e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.98e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"}},{"Gene":"CEP170","Gene synonym":["FAM68A","KAB","KIAA0470"],"Ensembl":"ENSG00000143702","Gene description":"Centrosomal protein 170","Uniprot":["Q5SW79"],"Chromosome":"1","Position":"243124428-243255348","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"49.6","brain":"22.8","testis":"85.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"117.7","Bergmann glia":"122.6","Brain excitatory neurons":"153.9","Brain inhibitory neurons":"147.0","Early spermatids":"211.3","Late spermatids":"1375.9","Microglia":"465.0","Oligodendrocyte progenitor cells":"157.7","Oligodendrocytes":"314.7","Other brain neurons":"137.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"465.0","Spermatogenic cell types":"1375.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":76,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA042151":null,"HPA045597":null,"HPA045787":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.50e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.93e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"}},{"Gene":"CEP19","Gene synonym":["C3orf34","MGC14126"],"Ensembl":"ENSG00000174007","Gene description":"Centrosomal protein 19","Uniprot":["Q96LK0"],"Chromosome":"3","Position":"196706277-196712250","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"50.7","Early primary spermatocytes":"43.4","Fallopian tube ciliated cells":"30.3","Late primary spermatocytes":"112.8","Neutrophils":"86.5","Respiratory ciliated cells":"38.2","Undifferentiated spermatogonia":"33.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"86.5","Spermatogenic cell types":"112.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"basophil":"50.9","eosinophil":"58.8","neutrophil":"143.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"143.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1262","Protein cell type specific Intensity":{"Fallopian tube cells":"126222.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"114","Protein tissue specific Intensity":{"fallopian tube":"11388.5"},"Antibody":["HPA047614","HPA071138"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":64,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA047614":null,"HPA071138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2088449.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5310","Protein tissue specific Intensity":{"fallopian tube":"530986.4"},"Antibody":["HPA040599"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centriolar satellite","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Centriolar satellite","Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA040599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"}},{"Gene":"CEP250","Gene synonym":["C-NAP1","CEP2"],"Ensembl":"ENSG00000126001","Gene description":"Centrosomal protein 250","Uniprot":["Q9BV73"],"Chromosome":"20","Position":"35455164-35519280","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Cone-rod dystrophy","Deafness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"8121059.8","B-cells":"4799239.9","Fallopian tube cells":"2628268.5","Oocytes":"8076964.9","T-cells":"5120257.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"6732540.3","lymphoid tissue":"3527894.3"},"Antibody":["HPA064875","HPA069380"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":18,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA064875":null,"HPA069380":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.74e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.76e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"}},{"Gene":"CEP295NL","Gene synonym":["DDC8","KIAA1731NL"],"Ensembl":"ENSG00000178404","Gene description":"CEP295 N-terminal like","Uniprot":["Q96MC4"],"Chromosome":"17","Position":"78890579-78903217","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"26.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"2.0","Late spermatids":"3.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"34","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"memory B-cell":"5.5","naive B-cell":"4.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"5.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"4.4"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"906","Protein tissue specific Intensity":{"skin":"121224.2","Stomach":"59889.7"},"Antibody":["HPA023609","HPA024619","HPA025717"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA023609":null,"HPA024619":null,"HPA025717":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.86e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CEP350","Gene synonym":["CAP350","KIAA0480"],"Ensembl":"ENSG00000135837","Gene description":"Centrosomal protein 350","Uniprot":["Q5VT06"],"Chromosome":"1","Position":"179954674-180114880","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1017.4","Late spermatids":"1168.8","Neutrophil progenitors":"721.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1168.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":41,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Basal body","End piece"],"Antibody RRID":{"CAB079754":null,"HPA028355":null,"HPA028357":null,"HPA030845":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"CEP41","Gene synonym":["DKFZp762H1311","FLJ22445","JBTS15","TSGA14"],"Ensembl":"ENSG00000106477","Gene description":"Centrosomal protein 41","Uniprot":["Q9BYV8"],"Chromosome":"7","Position":"130393771-130442433","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Autism","Autism spectrum disorder","Ciliopathy","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"47.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"562.2","Late primary spermatocytes":"451.1","Late spermatids":"205.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"562.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"105.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2450154.1","Microglia and Neuropil":"2431840.3","Neurons":"2314528.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"4396890.2","liver":"4038030.2","pancreas":"3428782.0"},"Antibody":["HPA024090","HPA062216"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Primary cilium"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA024090":null,"HPA062216":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"}},{"Gene":"CEP43","Gene synonym":["FGFR1OP","FOP"],"Ensembl":"ENSG00000213066","Gene description":"Centrosomal protein 43","Uniprot":["O95684"],"Chromosome":"6","Position":"166999174-167052718","Protein class":["Cancer-related genes","Disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"43.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"56.5","Brain excitatory neurons":"84.5","Brain inhibitory neurons":"88.5","Choroid plexus epithelial cells":"102.6","Distal convoluted tubule cells":"78.0","Early spermatids":"168.8","Ependymal cells":"247.4","Late primary spermatocytes":"64.6","Late spermatids":"173.0","Loop of henle epithelial cells":"73.8","Other brain neurons":"65.4","Podocytes":"67.1","Proximal tubule cells":"110.0","Renal collecting duct intercalated cells":"79.5","Renal collecting duct principal cells":"70.9","Renal connecting tubule cells":"59.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"247.4","Ductal cells":"79.5","Neuronal cells":"88.5","Renal nephron cells":"110.0","Spermatogenic cell types":"173.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"30.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":28,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"HPA071876":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"}},{"Gene":"CEP44","Gene synonym":["KIAA1712"],"Ensembl":"ENSG00000164118","Gene description":"Centrosomal protein 44","Uniprot":["Q9C0F1"],"Chromosome":"4","Position":"174283730-174333380","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in all","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"125.8"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"809618.8","ovary":"3117286.6"},"Antibody":["HPA041515","HPA041835"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":58,"Subcellular main location":["Basal body","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041515":null,"HPA041835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.16e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.06e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"}},{"Gene":"CEP55","Gene synonym":["C10orf3","CT111","FLJ10540"],"Ensembl":"ENSG00000138180","Gene description":"Centrosomal protein 55","Uniprot":["Q53EZ4"],"Chromosome":"10","Position":"93496612-93529092","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"25.5","testis":"20.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"22.6","Early primary spermatocytes":"39.4","Early spermatids":"21.1","Enteric transient amplifying cells":"25.7","Esophageal basal cells":"26.9","Extravillous trophoblasts":"21.7","Gastric progenitor cells":"34.6","Hofbauer cells":"20.8","Late primary spermatocytes":"100.9","Megakaryocyte progenitors":"31.1","Monocyte progenitors":"149.7","Neutrophil progenitors":"26.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"149.7","Spermatogenic cell types":"100.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"T-reg":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"14","RNA blood lineage specific nTPM":{"T-cells":"1.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Pituitary gland - Corticotropes","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"6684","Protein cell type specific Intensity":{"Granulosa cells":"690548.7","Oocytes":"646235.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023430"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Plasma membrane","Midbody","Primary cilium","Centriolar satellite","Cytosol","Connecting piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":107,"Subcellular main location":["Plasma membrane","Centriolar satellite"],"Subcellular additional location":["Midbody","Primary cilium","Cytosol","Connecting piece","Principal piece"],"Antibody RRID":{"HPA023430":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.09e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.50e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-15"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.31e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.22e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.67e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"}},{"Gene":"CEP57","Gene synonym":["KIAA0092","Translokin","TSP57"],"Ensembl":"ENSG00000166037","Gene description":"Centrosomal protein 57","Uniprot":["Q86XR8"],"Chromosome":"11","Position":"95789965-95832693","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"556.4","Late spermatids":"552.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"556.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"370938.1","Large ducts":"851571.7","Neurons":"1203894.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"2830","Protein tissue specific Intensity":{"bone marrow":"399752.5","fallopian tube":"283060.0","lymphoid tissue":"166291.5"},"Antibody":["HPA018315","HPA066403"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centriolar satellite","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":16,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Centriolar satellite","Cytosol"],"Antibody RRID":{"HPA018315":null,"HPA066403":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.14e-7"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - 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Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"213","Protein cell type specific Intensity":{"Fallopian tube cells":"21274.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040378"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":28,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040378":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"CEP63","Gene synonym":["FLJ13386"],"Ensembl":"ENSG00000182923","Gene description":"Centrosomal protein 63","Uniprot":["Q96MT8"],"Chromosome":"3","Position":"134485699-134587789","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","Host-virus interaction","Mitosis"],"Molecular function":null,"Disease involvement":["Dwarfism","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"55.9","Bergmann glia":"65.5","Brain excitatory neurons":"62.9","Brain inhibitory neurons":"53.6","Choroid plexus epithelial cells":"48.9","Distal convoluted tubule cells":"49.0","Ependymal cells":"61.9","Loop of henle epithelial cells":"54.9","Microglia":"99.8","Oligodendrocyte progenitor cells":"79.7","Oligodendrocytes":"89.5","Other brain neurons":"46.9","Papillary tip epithelial cells":"44.9","Podocytes":"39.7","Proximal tubule cells":"42.6","Renal collecting duct intercalated cells":"39.1","Renal collecting duct principal cells":"44.0","Renal connecting tubule cells":"42.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"61.9","Ductal cells":"44.0","Glial cells":"99.8","Neuronal cells":"62.9","Renal nephron cells":"54.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"123.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"123.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1112949.0","Oocytes":"973206.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036264","HPA058154"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":68,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA036264":null,"HPA058154":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.02e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.84e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.24e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"}},{"Gene":"CEP70","Gene synonym":["BITE","FLJ13036"],"Ensembl":"ENSG00000114107","Gene description":"Centrosomal protein 70","Uniprot":["Q8NHQ1"],"Chromosome":"3","Position":"138494344-138594538","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"260.8","Fallopian tube ciliated cells":"259.6","Late primary spermatocytes":"406.1","Late spermatids":"450.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"450.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"gdT-cell":"2.7","MAIT T-cell":"3.3","memory B-cell":"1.7","memory CD4 T-cell":"2.1","memory CD8 T-cell":"2.3","naive B-cell":"1.4","naive CD4 T-cell":"4.0","naive CD8 T-cell":"4.0","NK-cell":"2.2","T-reg":"1.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"B-cells":"1.7","NK-cells":"2.2","T-cells":"4.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Alveolar cells type 2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2621921.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036941","HPA036942"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":232,"Subcellular main location":["Nucleoplasm","Primary cilium","Cytosol"],"Subcellular additional location":["Centrosome","Basal body"],"Antibody RRID":{"HPA036941":null,"HPA036942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.80e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"CEP76","Gene synonym":["C18orf9","FLJ12542","HsT1705"],"Ensembl":"ENSG00000101624","Gene description":"Centrosomal protein 76","Uniprot":["Q8TAP6"],"Chromosome":"18","Position":"12661833-12702777","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"293.0","Late primary spermatocytes":"76.3","Late spermatids":"72.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"293.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"9","RNA mouse brain regional specific nTPM":{"cerebellum":"55.0"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2023816.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"2711","Protein tissue specific Intensity":{"fallopian tube":"142329.0","lymphoid tissue":"399906.0"},"Antibody":["HPA039395"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Plasma membrane","Microtubules","Mitotic spindle","Primary cilium","Cytosol","Perinuclear theca","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":98,"Subcellular main location":["Microtubules","Mitotic spindle","Primary cilium","Perinuclear theca","Flagellar centriole"],"Subcellular additional location":["Nucleoplasm","Plasma membrane","Cytosol"],"Antibody RRID":{"HPA039395":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.48e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"CEP83","Gene synonym":["CCDC41","NPHP18","NY-REN-58"],"Ensembl":"ENSG00000173588","Gene description":"Centrosomal protein 83","Uniprot":["Q9Y592"],"Chromosome":"12","Position":"94306449-94459988","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Nephronophthisis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"640.9","Ependymal cells":"461.7","Fallopian tube ciliated cells":"261.4","Respiratory ciliated cells":"360.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"640.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"474.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"4855001.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"103","Protein tissue specific Intensity":{"fallopian tube":"10322.9"},"Antibody":["HPA038161"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus","Vesicles","Primary cilium","Primary cilium transition zone"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Golgi apparatus","Vesicles","Primary cilium","Primary cilium transition zone"],"Subcellular additional location":null,"Antibody RRID":{"HPA038161":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.43e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"}},{"Gene":"CEP85L","Gene synonym":["bA57K17.2","C6orf204","NY-BR-15"],"Ensembl":"ENSG00000111860","Gene description":"Centrosomal protein 85 like","Uniprot":["Q5SZL2"],"Chromosome":"6","Position":"118460772-118710075","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"28.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"619.2","Cardiomyocytes":"4033.8","Early spermatids":"619.8","Late spermatids":"1278.8","Myonuclei":"731.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"4033.8","Spermatogenic cell types":"1278.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"6.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029137":null,"HPA029138":null,"HPA029139":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"}},{"Gene":"CERKL","Gene synonym":["RP26"],"Ensembl":"ENSG00000188452","Gene description":"Ceramide kinase like","Uniprot":["Q49MI3"],"Chromosome":"2","Position":"181535041-181680665","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"7.7","kidney":"8.1","retina":"19.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"39.9","Choroid plexus epithelial cells":"67.0","Cone photoreceptor cells":"84.9","Endometrial ciliated cells":"145.7","Ependymal cells":"153.6","Epididymal efferent duct ciliated cells":"73.4","Fallopian tube ciliated cells":"98.0","Gonadotrophs":"46.3","Pancreatic islet cells":"39.1","Respiratory ciliated cells":"168.4","Rod photoreceptor cells":"131.1","Thymocytes":"69.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"168.4","Neuronal cells":"131.1","T-cells":"69.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"59.6","ependymal cell":"169.1","upper rhombic lip":"126.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"28.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"5.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Lung - Respiratory ciliated cells","Pancreas - Alpha cells","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"cerebellum":"18.5"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035443","HPA035444","HPA043203"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035443":null,"HPA035444":null,"HPA043203":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.65e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"}},{"Gene":"CERS3","Gene synonym":["LASS3","MGC27091"],"Ensembl":"ENSG00000154227","Gene description":"Ceramide synthase 3","Uniprot":["Q8IU89"],"Chromosome":"15","Position":"100400395-100544995","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Transferase"],"Disease involvement":["Ichthyosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"53.1","skin 1":"61.6","vagina":"29.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Esophageal apical cells":"819.2","Esophageal suprabasal cells":"357.9","Suprabasal keratinocytes":"241.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"819.2","Suprabasal cells":"357.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"19.2","Head and Neck Squamous Cell Carcinoma (TCGA)":"43.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Esophageal cancer":"2.9","head and neck cancer":"10.6"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":36,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA006092":null,"HPA024356":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"}},{"Gene":"CERT1","Gene synonym":["CERT","COL4A3BP","GPBP","STARD11"],"Ensembl":"ENSG00000113163","Gene description":"Ceramide transporter 1","Uniprot":["Q9Y5P4"],"Chromosome":"5","Position":"75356345-75512138","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"573.4","Neutrophils":"715.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"715.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"37000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":19,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035645":null,"HPA042608":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.56e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"}},{"Gene":"CETN1","Gene synonym":["CEN1","CETN"],"Ensembl":"ENSG00000177143","Gene description":"Centrin 1","Uniprot":["Q12798"],"Chromosome":"18","Position":"580380-582114","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"1230","RNA tissue specific nTPM":{"testis":"128.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"771.1","Late primary spermatocytes":"2025.8","Late spermatids":"494.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"148","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2025.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028956","CAB037244","HPA069157"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Flagellar centriole","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":23,"Subcellular main location":["Nucleoplasm","Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"CAB037244":null,"HPA028956":null,"HPA069157":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CETN3","Gene synonym":["CEN3"],"Ensembl":"ENSG00000153140","Gene description":"Centrin 3","Uniprot":["O15182"],"Chromosome":"5","Position":"90392257-90409766","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"121.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early primary spermatocytes":"321.5","Late primary spermatocytes":"969.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"969.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":38,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA035608":null,"HPA063704":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.41e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"CFAP100","Gene synonym":["CCDC37","FLJ40083","MIA1"],"Ensembl":"ENSG00000163885","Gene description":"Cilia and flagella associated protein 100","Uniprot":["Q494V2"],"Chromosome":"3","Position":"126394909-126436556","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"12.6","fallopian tube":"25.5","testis":"30.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"421.0","Endometrial ciliated cells":"157.0","Ependymal cells":"313.9","Fallopian tube ciliated cells":"142.8","Late primary spermatocytes":"102.0","Late spermatids":"1113.7","Respiratory ciliated cells":"280.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Ciliated cells":"313.9","Spermatogenic cell types":"1113.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"306.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"4.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA046354":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"}},{"Gene":"CFAP107","Gene synonym":["C1orf158","MGC35194"],"Ensembl":"ENSG00000157330","Gene description":"Cilia and flagella associated protein 107","Uniprot":["Q8N1D5"],"Chromosome":"1","Position":"12746200-12763699","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"choroid plexus":"44.0","fallopian tube":"25.1","testis":"46.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"127.7","Early spermatids":"172.2","Endometrial ciliated cells":"68.8","Ependymal cells":"137.1","Epididymal efferent duct ciliated cells":"53.7","Fallopian tube ciliated cells":"140.5","Late primary spermatocytes":"278.7","Late spermatids":"114.8","Respiratory ciliated cells":"145.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Ciliated cells":"145.7","Spermatogenic cell types":"278.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"28","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"90.7","ependymal cell":"141.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.0","Ovary Serous Cystadenocarcinoma (TCGA)":"2.4","Uterine Corpus Endometrial Carcinoma (TCGA)":"9.4"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"39.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA028396":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"}},{"Gene":"CFAP119","Gene synonym":["C16orf93","CCDC189","MGC104706"],"Ensembl":"ENSG00000196118","Gene description":"Cilia and flagella associated protein 119","Uniprot":["A1A4V9"],"Chromosome":"16","Position":"30757423-30762221","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"36.5","testis":"22.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"182.1","Endometrial ciliated cells":"52.7","Epididymal efferent duct ciliated cells":"78.5","Fallopian tube ciliated cells":"79.5","Late primary spermatocytes":"156.9","Late spermatids":"465.7","Respiratory ciliated cells":"96.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"465.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"45.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"12.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"9321","Protein cell type specific Intensity":{"Fallopian tube cells":"932137.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"120","Protein tissue specific Intensity":{"fallopian tube":"12028.1"},"Antibody":["HPA041806","HPA046289","HPA075094"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Cytosol","Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA041806":null,"HPA046289":null,"HPA075094":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"}},{"Gene":"CFAP126","Gene synonym":["C1orf192","Flattop","Fltp"],"Ensembl":"ENSG00000188931","Gene description":"Cilia and flagella associated protein 126","Uniprot":["Q5VTH2"],"Chromosome":"1","Position":"161364733-161367876","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"202.0","fallopian tube":"142.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"238.8","Epididymal efferent duct ciliated cells":"477.2","Fallopian tube ciliated cells":"544.0","Late primary spermatocytes":"161.5","Respiratory ciliated cells":"388.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Ciliated cells":"544.0","Spermatogenic cell types":"161.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"15","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"22.4","ependymal cell":"64.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"57.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Plasma membrane","Primary cilium","Mid piece"],"Subcellular additional location":["Vesicles","Cytosol","Principal piece"],"Antibody RRID":{"HPA045904":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"}},{"Gene":"CFAP141","Gene synonym":["C1orf189"],"Ensembl":"ENSG00000163263","Gene description":"Cilia and flagella associated protein 141","Uniprot":["Q5VU69"],"Chromosome":"1","Position":"154199085-154206333","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"fallopian tube":"28.7","testis":"24.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"165.8","Endometrial ciliated cells":"89.3","Epididymal efferent duct ciliated cells":"180.9","Fallopian tube ciliated cells":"135.7","Late primary spermatocytes":"207.1","Respiratory ciliated cells":"157.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Ciliated cells":"180.9","Spermatogenic cell types":"207.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"12.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"6.3"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"midbrain":"6.9"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021474":null,"HPA021786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"}},{"Gene":"CFAP161","Gene synonym":["C15orf26","FLJ38615"],"Ensembl":"ENSG00000156206","Gene description":"Cilia and flagella associated protein 161","Uniprot":["Q6P656"],"Chromosome":"15","Position":"81007033-81149179","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"20.3","fallopian tube":"14.9","testis":"6.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"523.3","Endometrial secretory cells":"110.8","Retinal amacrine cells":"73.0","Retinal pigment epithelial cells":"191.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"523.3","Pigment cells":"191.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"388.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"choroid plexus":"80.5"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"17","RNA cell line specific nTPM":{"Leukemia":"10.4"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA076975":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"CFAP20","Gene synonym":["C16orf80","fSAP23","GTL3"],"Ensembl":"ENSG00000070761","Gene description":"Cilia and flagella associated protein 20","Uniprot":["Q9Y6A4"],"Chromosome":"16","Position":"58113592-58129381","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"402.7","Late primary spermatocytes":"163.3","Late spermatids":"162.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"402.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"91.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"40310549.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"10838617.3"},"Antibody":["HPA018195"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Equatorial segment","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":37,"Subcellular main location":["Nucleoplasm","Principal piece"],"Subcellular additional location":["Equatorial segment"],"Antibody RRID":{"HPA018195":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"}},{"Gene":"CFAP206","Gene synonym":["C6orf165","dJ382I10.1","FLJ25974"],"Ensembl":"ENSG00000272514","Gene description":"Cilia and flagella associated protein 206","Uniprot":["Q8IYR0"],"Chromosome":"6","Position":"87407972-87464465","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"fallopian tube":"21.0","testis":"55.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"29.3","Ependymal cells":"105.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Ciliated cells":"105.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"116.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"4.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"18920","Protein cell type specific Intensity":{"Fallopian tube cells":"1891998.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1079","Protein tissue specific Intensity":{"fallopian tube":"107856.9"},"Antibody":["HPA044891"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":46,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044891":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"CFAP20DC","Gene synonym":["C3orf67","FLJ42117","FLJ42930"],"Ensembl":"ENSG00000163689","Gene description":"CFAP20 domain containing","Uniprot":["Q6ZVT6"],"Chromosome":"3","Position":"58717365-59050084","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"esophagus":"8.1","testis":"20.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"170.7","Ependymal cells":"97.3","Esophageal apical cells":"523.8","Esophageal suprabasal cells":"109.3","Gonadotrophs":"111.3","Late primary spermatocytes":"131.1","Late spermatids":"176.3","Ocular epithelial cells":"83.5","Respiratory ciliated cells":"126.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"523.8","Ciliated cells":"126.1","Spermatogenic cell types":"176.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"113.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA069696"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA069696":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.65e-6"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.47e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"}},{"Gene":"CFAP210","Gene synonym":["C2orf77","CCDC173","LOC129881"],"Ensembl":"ENSG00000154479","Gene description":"Cilia and flagella associated protein 210","Uniprot":["Q0VFZ6"],"Chromosome":"2","Position":"169645425-169694405","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"choroid plexus":"44.5","testis":"74.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"855.4","Endometrial ciliated cells":"438.3","Ependymal cells":"436.4","Epididymal efferent duct ciliated cells":"433.1","Fallopian tube ciliated cells":"575.3","Late primary spermatocytes":"1594.4","Respiratory ciliated cells":"679.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Ciliated cells":"679.8","Spermatogenic cell types":"1594.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"151.9","ependymal cell":"472.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"4.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042995":null,"HPA048454":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"}},{"Gene":"CFAP221","Gene synonym":["FAP221","PCDP1"],"Ensembl":"ENSG00000163075","Gene description":"Cilia and flagella associated protein 221","Uniprot":["Q4G0U5"],"Chromosome":"2","Position":"119544432-119662251","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Calmodulin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"27.8","testis":"23.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"165.9","Distal convoluted tubule cells":"178.8","Early spermatids":"171.6","Endometrial ciliated cells":"265.2","Ependymal cells":"688.0","Epididymal efferent duct ciliated cells":"332.8","Fallopian tube ciliated cells":"448.4","Late primary spermatocytes":"203.2","Late spermatids":"489.2","Loop of henle epithelial cells":"209.4","Respiratory ciliated cells":"574.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"688.0","Renal nephron cells":"209.4","Spermatogenic cell types":"489.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"756.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"3.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"8268","Protein cell type specific Intensity":{"Fallopian tube cells":"826796.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"61343","Protein tissue specific Intensity":{"fallopian tube":"6134271.0"},"Antibody":["HPA042501","HPA054164"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium","Primary cilium tip","Connecting piece","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Primary cilium","Primary cilium tip","Connecting piece","Flagellar centriole"],"Subcellular additional location":null,"Antibody RRID":{"HPA042501":null,"HPA054164":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.89e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.92e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"CFAP251","Gene synonym":["CaM-IP4","MGC33630","WDR66"],"Ensembl":"ENSG00000158023","Gene description":"Cilia and flagella associated protein 251","Uniprot":["Q8TBY9"],"Chromosome":"12","Position":"121918592-122003927","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"19.0","fallopian tube":"20.9","testis":"18.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"151.3","Endometrial ciliated cells":"207.5","Ependymal cells":"363.9","Epididymal efferent duct ciliated cells":"169.1","Fallopian tube ciliated cells":"185.0","Respiratory ciliated cells":"444.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"444.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"379.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"plasmacytoid DC":"1.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"dendritic cells":"1.6"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"19.0"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA039902":null,"HPA040005":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.43e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.85e-6"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA049684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"CFAP298","Gene synonym":["C21orf48","C21orf59","CILD26","DNAAF16","FBB18","FLJ20467","Kur"],"Ensembl":"ENSG00000159079","Gene description":"Cilia and flagella associated protein 298","Uniprot":["P57076"],"Chromosome":"21","Position":"32592079-32612603","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"99.2","Endometrial ciliated cells":"101.2","Epididymal efferent duct ciliated cells":"128.0","Fallopian tube ciliated cells":"170.8","Late primary spermatocytes":"308.8","Respiratory ciliated cells":"134.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"170.8","Spermatogenic cell types":"308.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":11,"Subcellular main location":["Basal body","Cytosol","Principal piece"],"Subcellular additional location":["Nucleoplasm","Microtubules","Primary cilium transition zone","Centrosome"],"Antibody RRID":{"CAB034170":null,"HPA018453":null,"HPA019055":null,"HPA028849":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"}},{"Gene":"CFAP299","Gene synonym":["C4orf22"],"Ensembl":"ENSG00000197826","Gene description":"Cilia and flagella associated protein 299","Uniprot":["Q6V702"],"Chromosome":"4","Position":"80335730-80963750","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"18.6","testis":"25.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"388.6","Endometrial ciliated cells":"1250.7","Ependymal cells":"5123.3","Epididymal efferent duct ciliated cells":"1020.3","Fallopian tube ciliated cells":"1252.2","Respiratory ciliated cells":"3061.6","Respiratory deuterosomal cells":"401.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Ciliated cells":"5123.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"ependymal cell":"5547.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.3"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"14364","Protein cell type specific Intensity":{"Fallopian tube cells":"1436436.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4476","Protein tissue specific Intensity":{"fallopian tube":"447626.1"},"Antibody":["HPA043383"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":3,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043383":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-1"}},{"Gene":"CFAP300","Gene synonym":["C11orf70","DNAAF17","FBB5","MGC13040"],"Ensembl":"ENSG00000137691","Gene description":"Cilia and flagella associated protein 300","Uniprot":["Q9BRQ4"],"Chromosome":"11","Position":"102047437-102084554","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"23.0","fallopian tube":"27.4","testis":"28.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early primary spermatocytes":"171.6","Early spermatids":"317.0","Endometrial ciliated cells":"157.0","Ependymal cells":"145.6","Epididymal efferent duct ciliated cells":"147.3","Fallopian tube ciliated cells":"228.0","Late primary spermatocytes":"553.9","Respiratory ciliated cells":"339.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"339.7","Spermatogenic cell types":"553.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"64.8","ependymal cell":"170.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Primary cilium","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA038585":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Nuclear bodies","Primary cilium","Cytosol"],"Antibody RRID":{"HPA008994":null,"HPA017061":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Flagellar centriole"],"Subcellular additional location":["Nuclear membrane","Cytosol","Mid piece","Principal piece"],"Antibody RRID":{"HPA038127":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"}},{"Gene":"CFAP44","Gene synonym":["FLJ11142","WDR52"],"Ensembl":"ENSG00000206530","Gene description":"Cilia and flagella associated protein 44","Uniprot":["Q96MT7"],"Chromosome":"3","Position":"113286930-113441610","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"609.4","Ependymal cells":"1353.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Ciliated cells":"1353.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"526.2","ependymal cell":"1447.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA067258":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Basal body","Cytosol"],"Antibody RRID":{"HPA042204":null,"HPA043618":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"}},{"Gene":"CFAP46","Gene synonym":["bA288G11.4","bA288G11.5","bB137A17.2","bB137A17.3","C10orf123","C10orf124","C10orf92","C10orf93","DKFZp434A1721","FLJ25954","TTC40"],"Ensembl":"ENSG00000171811","Gene description":"Cilia and flagella associated protein 46","Uniprot":["Q8IYW2"],"Chromosome":"10","Position":"132808392-132942823","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"29.3","testis":"39.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"181.4","Cone photoreceptor cells":"111.8","Endometrial ciliated cells":"290.2","Ependymal cells":"592.2","Epididymal efferent duct ciliated cells":"261.9","Fallopian tube ciliated cells":"249.6","Respiratory ciliated cells":"430.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"592.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"519.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","Annulus"],"Subcellular additional location":null,"Antibody RRID":{"HPA037786":null,"HPA038034":null,"HPA038867":null,"HPA038868":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - 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Respiratory ciliated cells","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"642830.2","Smooth muscle cells":"2298675.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"1004439.8"},"Antibody":["HPA044633","HPA054859"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044633":null,"HPA054859":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"}},{"Gene":"CFAP52","Gene synonym":["FLJ37528","WDR16","WDRPUH"],"Ensembl":"ENSG00000166596","Gene description":"Cilia and flagella associated protein 52","Uniprot":["Q8N1V2"],"Chromosome":"17","Position":"9576627-9643447","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Heterotaxy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"37.4","fallopian tube":"54.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"118.5","Endometrial ciliated cells":"225.8","Ependymal cells":"555.1","Epididymal efferent duct ciliated cells":"250.1","Fallopian tube ciliated cells":"370.3","Late primary spermatocytes":"88.6","Respiratory ciliated cells":"504.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"555.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"591.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Primary cilium","Centriolar satellite","Basal body"],"Antibody RRID":{"HPA023247":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"}},{"Gene":"CFAP53","Gene synonym":["CCDC11","FLJ32743"],"Ensembl":"ENSG00000172361","Gene description":"Cilia and flagella associated protein 53","Uniprot":["Q96M91"],"Chromosome":"18","Position":"50227193-50266495","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Ciliopathy","Disease variant","Heterotaxy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"choroid plexus":"19.4","fallopian tube":"26.8","testis":"76.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"699.4","Endometrial ciliated cells":"414.7","Epididymal efferent duct ciliated cells":"409.2","Fallopian tube ciliated cells":"446.2","Late primary spermatocytes":"1365.9","Late spermatids":"741.6","Respiratory ciliated cells":"538.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Ciliated cells":"538.9","Spermatogenic cell types":"1365.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"50.0","ependymal cell":"181.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"8.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":23,"Subcellular main location":["Basal body","Cytosol"],"Subcellular additional location":["Nucleoplasm","Nuclear membrane"],"Antibody RRID":{"HPA066142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"}},{"Gene":"CFAP54","Gene synonym":["C12orf55","C12orf63","FLJ31514","FLJ44112"],"Ensembl":"ENSG00000188596","Gene description":"Cilia and flagella associated protein 54","Uniprot":["Q96N23"],"Chromosome":"12","Position":"96489571-96875555","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"6.5","retina":"5.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1724.1","Endometrial ciliated cells":"604.5","Ependymal cells":"3174.7","Epididymal efferent duct ciliated cells":"438.2","Fallopian tube ciliated cells":"695.9","Respiratory ciliated cells":"1426.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Ciliated cells":"3174.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1391.7","ependymal cell":"3403.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Plasma cells","Stomach - Plasma cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"20040","Protein cell type specific Intensity":{"Fallopian tube cells":"2004009.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"848827.5"},"Antibody":["HPA039897"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Microtubules","Cytokinetic bridge","Primary cilium"],"Subcellular additional location":["Basal body","Cytosol"],"Antibody RRID":{"HPA039897":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"}},{"Gene":"CFAP57","Gene synonym":["FLJ32000","WDR65"],"Ensembl":"ENSG00000243710","Gene description":"Cilia and flagella associated protein 57","Uniprot":["Q96MR6"],"Chromosome":"1","Position":"43172330-43254358","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"13.2","fallopian tube":"22.0","testis":"14.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"47.6","Endometrial ciliated cells":"118.3","Ependymal cells":"114.6","Epididymal efferent duct ciliated cells":"86.9","Fallopian tube ciliated cells":"188.0","Late primary spermatocytes":"75.3","Late spermatids":"40.6","Respiratory ciliated cells":"232.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"232.8","Spermatogenic cell types":"75.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"42.1","ependymal cell":"126.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"23.2"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"4.1","lymphoma":"3.7"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Lung - Respiratory ciliated cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"245291","Protein cell type specific Intensity":{"Fallopian tube cells":"11196073.7","Microglia and Neuropil":"37862170.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"162563","Protein tissue specific Intensity":{"fallopian tube":"16256284.5"},"Antibody":["HPA002736","HPA028623","HPA028629"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Primary cilium","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA002736":null,"HPA028623":null,"HPA028629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"}},{"Gene":"CFAP58","Gene synonym":["bA554P13.1","C10orf80","CCDC147","FLJ35908"],"Ensembl":"ENSG00000120051","Gene description":"Cilia and flagella associated protein 58","Uniprot":["Q5T655"],"Chromosome":"10","Position":"104353833-104455102","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"7.9","testis":"12.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"46.5","Endometrial ciliated cells":"52.2","Ependymal cells":"207.0","Epididymal efferent duct ciliated cells":"60.9","Fallopian tube ciliated cells":"132.2","Late primary spermatocytes":"107.6","Late spermatids":"77.6","Myonuclei":"35.8","Neutrophils":"50.5","Respiratory ciliated cells":"171.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"207.0","Neutrophils":"50.5","Spermatogenic cell types":"107.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"15","RNA single nuclei brain specific nCPM":{"ependymal cell":"221.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"2.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"21","RNA blood lineage specific nTPM":{"granulocytes":"2.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"2.6"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"89251","Protein cell type specific Intensity":{"Fallopian tube cells":"14244905.0","T-cells":"3605351.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"71889","Protein tissue specific Intensity":{"fallopian tube":"7188872.9"},"Antibody":["HPA036555","HPA071938"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Calyx","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":5,"Subcellular main location":["Principal piece"],"Subcellular additional location":["Calyx"],"Antibody RRID":{"HPA036555":null,"HPA071938":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CFAP61","Gene synonym":["C20orf26","CaM-IP3","dJ1002M8.3","DKFZP434K156"],"Ensembl":"ENSG00000089101","Gene description":"Cilia and flagella associated protein 61","Uniprot":["Q8NHU2"],"Chromosome":"20","Position":"20052514-20360703","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"11.4","heart muscle":"11.6","skeletal muscle":"26.0","testis":"14.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"286.5","Choroid plexus epithelial cells":"315.0","Early spermatids":"143.2","Endometrial ciliated cells":"199.6","Ependymal cells":"600.0","Epididymal efferent duct ciliated cells":"149.4","Fallopian tube ciliated cells":"198.1","Late spermatids":"215.1","Myonuclei":"226.9","Respiratory ciliated cells":"476.7","Somatotrophs":"242.4","Thymic myoid cells":"477.2","Thyrotrophs":"207.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"600.0","Myocytes":"286.5","Pituitary endocrine cells":"242.4","Spermatogenic cell types":"215.1","Stromal cells":"477.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"246.0","ependymal cell":"616.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.8","skin cancer":"5.0"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol","Principal piece"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA009079":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"CFAP65","Gene synonym":["CCDC108","DKFZp434O0527","MGC35338"],"Ensembl":"ENSG00000181378","Gene description":"Cilia and flagella associated protein 65","Uniprot":["Q6ZU64"],"Chromosome":"2","Position":"219002846-219041527","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"8.9","fallopian tube":"24.2","retina":"8.5","testis":"8.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"270.4","Endometrial ciliated cells":"76.0","Ependymal cells":"201.5","Epididymal efferent duct ciliated cells":"88.6","Fallopian tube ciliated cells":"128.4","Late primary spermatocytes":"167.1","Late spermatids":"308.7","Neuroendocrine cells":"54.8","Respiratory ciliated cells":"182.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"201.5","Spermatogenic cell types":"308.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"230.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"}},{"Gene":"CFAP69","Gene synonym":["C7orf63","FAP69","FLJ21062"],"Ensembl":"ENSG00000105792","Gene description":"Cilia and flagella associated protein 69","Uniprot":["A5D8W1"],"Chromosome":"7","Position":"90245174-90311063","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Olfaction","Sensory transduction","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"50.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"287.0","Endometrial ciliated cells":"369.8","Ependymal cells":"506.6","Epididymal efferent duct ciliated cells":"288.3","Fallopian tube ciliated cells":"338.3","Prostatic glandular cells":"537.7","Respiratory ciliated cells":"394.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"506.6","Glandular cells":"537.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"286.4","ependymal cell":"559.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"22.6"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"41.9"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"13.0"},"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA062883":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"}},{"Gene":"CFAP70","Gene synonym":["FLJ25765","TTC18"],"Ensembl":"ENSG00000156042","Gene description":"Cilia and flagella associated protein 70","Uniprot":[],"Chromosome":"10","Position":"73253762-73358864","Protein class":["Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"56.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"484.7","Endometrial ciliated cells":"408.0","Ependymal cells":"1125.6","Epididymal efferent duct ciliated cells":"248.0","Fallopian tube ciliated cells":"359.7","Respiratory ciliated cells":"673.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"1125.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"423.7","ependymal cell":"1161.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"3.6"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Centrosome","Basal body","Cytosol"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA037582":null,"HPA070304":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"CFAP74","Gene synonym":["C1orf222","FLJ45476","KIAA1751"],"Ensembl":"ENSG00000142609","Gene description":"Cilia and flagella associated protein 74","Uniprot":["Q9C0B2"],"Chromosome":"1","Position":"1921951-2003837","Protein class":["Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"3.6","fallopian tube":"6.5","testis":"4.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"72.6","Differentiating spermatogonia":"26.5","Endometrial ciliated cells":"75.5","Ependymal cells":"112.0","Epididymal efferent duct ciliated cells":"59.6","Fallopian tube ciliated cells":"94.4","Late primary spermatocytes":"26.9","Late spermatids":"35.0","Microglia":"35.7","Respiratory ciliated cells":"185.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"185.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"106.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028521":null,"HPA029274":null,"HPA030240":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021329":null,"HPA061069":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"}},{"Gene":"CFAP91","Gene synonym":["AAT-1","AAT1","AAT1alpha","C3orf15","CaM-IP2","MAATS1","SPATA26"],"Ensembl":"ENSG00000183833","Gene description":"Cilia and flagella associated protein 91","Uniprot":["Q7Z4T9"],"Chromosome":"3","Position":"119703022-119767102","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"15.4","fallopian tube":"13.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"324.2","Late primary spermatocytes":"243.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"324.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"2.3","ependymal cell":"4.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA074084":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.37e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"}},{"Gene":"CFAP92","Gene synonym":["FAP92","FLJ43738","KIAA1257"],"Ensembl":"ENSG00000114656","Gene description":"Cilia and flagella associated protein 92 (putative)","Uniprot":["Q9ULG3"],"Chromosome":"3","Position":"128909866-129002690","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"23.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"209.0","Ependymal cells":"147.7","Epicardial cells":"145.5","Late primary spermatocytes":"204.5","Late spermatids":"320.6","Oocytes":"87.5","Respiratory ciliated cells":"90.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"145.5","Ciliated cells":"147.7","Spermatogenic cell types":"320.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"164.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"neutrophil":"34.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"46","RNA blood lineage specific nTPM":{"granulocytes":"34.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042811":null,"HPA048445":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"CFAP95","Gene synonym":["C9orf135"],"Ensembl":"ENSG00000204711","Gene description":"Cilia and flagella associated protein 95","Uniprot":["Q5VTT2"],"Chromosome":"9","Position":"69820817-69906227","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"27.5","fallopian tube":"34.6","testis":"15.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"98.3","Cone photoreceptor cells":"72.5","Early spermatids":"137.3","Endometrial ciliated cells":"268.0","Epididymal efferent duct ciliated cells":"251.0","Fallopian tube ciliated cells":"535.1","Lactotrophs":"106.4","Late primary spermatocytes":"236.3","Respiratory ciliated cells":"505.2","Thyrotrophs":"89.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"535.1","Pituitary endocrine cells":"106.4","Spermatogenic cell types":"236.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"97.8","ependymal cell":"80.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"3.4","Testicular Germ Cell Tumor (TCGA)":"8.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"13.8"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"naive CD4 T-cell":"1.2","naive CD8 T-cell":"1.7","T-reg":"1.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"T-cells":"1.7"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"testis cancer":"4.1"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Pituitary gland - Lactotropes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"46540","Protein cell type specific Intensity":{"Fallopian tube cells":"4654044.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3252","Protein tissue specific Intensity":{"fallopian tube":"325215.0"},"Antibody":["HPA021261","HPA021325"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA021261":null,"HPA021325":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"}},{"Gene":"CFAP97","Gene synonym":["DKFZp434F1728","hmw","KIAA1430"],"Ensembl":"ENSG00000164323","Gene description":"Cilia and flagella associated protein 97","Uniprot":["Q9P2B7"],"Chromosome":"4","Position":"185159665-185209504","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"244.4","Late primary spermatocytes":"462.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"462.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1932274.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"16416","Protein tissue specific Intensity":{"fallopian tube":"1641646.9"},"Antibody":["HPA049446","HPA053335"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":10,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Primary cilium","Cytosol"],"Antibody RRID":{"HPA049446":null,"HPA053335":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.76e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.60e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.13e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"}},{"Gene":"CFAP97D1","Gene synonym":["C17orf105"],"Ensembl":"ENSG00000231256","Gene description":"CFAP97 domain containing 1","Uniprot":["B2RV13"],"Chromosome":"17","Position":"43780435-43787620","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"25","RNA tissue specific nTPM":{"testis":"12.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"1825.3","Late spermatids":"2392.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"596","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2392.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023071","HPA053028"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA023071":null,"HPA053028":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CFAP99","Gene synonym":[],"Ensembl":"ENSG00000206113","Gene description":"Cilia and flagella associated protein 99","Uniprot":["D6REC4"],"Chromosome":"4","Position":"2418974-2462942","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"15.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"24.3","Cone photoreceptor cells":"16.6","Endometrial ciliated cells":"33.3","Ependymal cells":"53.8","Epididymal efferent duct ciliated cells":"25.2","Fallopian tube ciliated cells":"33.7","Late primary spermatocytes":"45.7","Late spermatids":"27.7","Respiratory ciliated cells":"67.4","Rod photoreceptor cells":"16.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"67.4","Neuronal cells":"16.8","Spermatogenic cell types":"45.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"18.0","ependymal cell":"56.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Microtubules","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle"],"Antibody RRID":{"HPA071642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"}},{"Gene":"CFTR","Gene synonym":["ABC35","ABCC7","CF","CFTR\/MRP","dJ760C5.1","MRP7","TNR-CFTR"],"Ensembl":"ENSG00000001626","Gene description":"CF transmembrane conductance regulator","Uniprot":["P13569"],"Chromosome":"7","Position":"117287120-117715971","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel","Isomerase"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"gallbladder":"47.0","intestine":"42.2","pancreas":"187.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enteric stem cells":"290.2","Pancreatic duct cells":"3336.0","Respiratory ionocytes":"767.1","Salivary acinar cells":"332.1","Salivary ionocytes":"1519.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ductal cells":"3336.0","Ionocytes":"1519.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"247.2"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"42.5","Kidney Chromophobe (TCGA)":"86.1","Pancreatic Adenocarcinoma (TCGA)":"43.4","Rectum Adenocarcinoma (TCGA)":"43.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"24.2","Gastric cancer":"9.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":373,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB001951":null,"HPA021939":null,"HPA079652":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.43e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.02e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"}},{"Gene":"CGRRF1","Gene synonym":["CGR19","RNF197"],"Ensembl":"ENSG00000100532","Gene description":"Cell growth regulator with ring finger domain 1","Uniprot":["Q99675"],"Chromosome":"14","Position":"54509812-54539292","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell cycle","Growth arrest"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"127.4","Late primary spermatocytes":"221.8","Platelets":"221.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"221.6","Spermatogenic cell types":"221.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"5840","Protein cell type specific Intensity":{"Neutrophils":"584004.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"50","Protein tissue specific Intensity":{"cerebral cortex":"5011.1"},"Antibody":["HPA002930"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA002930":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.99e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.47e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"}},{"Gene":"CHAC2","Gene synonym":["GCG1"],"Ensembl":"ENSG00000143942","Gene description":"ChaC glutathione specific gamma-glutamylcyclotransferase 2","Uniprot":["Q8WUX2"],"Chromosome":"2","Position":"53767804-53775196","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"34.7","Late primary spermatocytes":"65.4","Plasma cells":"35.8","Respiratory ionocytes":"30.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"65.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA049235":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.81e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"}},{"Gene":"CHAF1B","Gene synonym":["CAF-1","CAF1","CAF1A","CAF1P60","MPHOSPH7","MPP7"],"Ensembl":"ENSG00000159259","Gene description":"Chromatin assembly factor 1 subunit B","Uniprot":["Q13112"],"Chromosome":"21","Position":"36385392-36419015","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","DNA damage","DNA repair","DNA replication"],"Molecular function":["Chaperone","Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"14.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"29.8","Erythrocyte progenitors":"28.0","Respiratory deuterosomal cells":"40.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"40.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1740938.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1069033.6"},"Antibody":["HPA021679","CAB033604"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":57,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB033604":null,"HPA021679":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.14e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.29e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.56e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.30e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"}},{"Gene":"CHCHD5","Gene synonym":["C2orf9","MGC11104","MIC14","MIX14"],"Ensembl":"ENSG00000125611","Gene description":"Coiled-coil-helix-coiled-coil-helix domain containing 5","Uniprot":["Q9BSY4"],"Chromosome":"2","Position":"112584240-112589275","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"330.1","Late spermatids":"379.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"379.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"68192.4","Distal tubules":"197823.0","Fallopian tube cells":"171516.2","Large ducts":"59804.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"1241160.1","kidney":"340314.5"},"Antibody":["HPA038263"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038263":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"}},{"Gene":"CHCHD6","Gene synonym":["CHCM1","MGC13016","Mic25","MICOS25","PPP1R23"],"Ensembl":"ENSG00000159685","Gene description":"Coiled-coil-helix-coiled-coil-helix domain containing 6","Uniprot":["Q9BRQ6"],"Chromosome":"3","Position":"126704240-126960420","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"62.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hofbauer cells":"387.6","Late primary spermatocytes":"255.6","Melanocytes":"455.3","Oocytes":"225.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"387.6","Pigment cells":"455.3","Spermatogenic cell types":"255.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"33431986.5"},"Antibody":["HPA047673","HPA051975"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":30,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA047673":null,"HPA051975":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.47e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"}},{"Gene":"CHCT1","Gene synonym":["C17orf64"],"Ensembl":"ENSG00000141371","Gene description":"CHD1 helical C-terminal domain containing 1","Uniprot":["Q86WR6"],"Chromosome":"17","Position":"60392429-60431426","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"219","RNA tissue specific nTPM":{"testis":"125.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"1117.4","Late primary spermatocytes":"1033.5","Late spermatids":"690.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"89","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1117.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"7.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"2.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"2.5","granulocytes":"1.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"1.0"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044415"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA044415":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHDH","Gene synonym":[],"Ensembl":"ENSG00000016391","Gene description":"Choline dehydrogenase","Uniprot":["Q8NE62"],"Chromosome":"3","Position":"53812335-53846419","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"35.1","liver":"33.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"64.1","Enteric stem cells":"69.7","Enterocytes":"66.8","Hepatocytes":"68.2","Late spermatids":"76.2","Paneth cells":"65.7","Proximal tubule cells":"132.8","Tuft cells":"138.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"132.8","Secretory gland support":"138.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"80.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"14","RNA blood cell specific nTPM":{"basophil":"3.0","T-reg":"1.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"granulocytes":"3.0","T-cells":"1.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Minor Salivary Gland - Smooth muscle cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"109930872.2","Proximal tubules":"415350651.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036632","HPA036633","HPA058130"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA036632":null,"HPA036633":null,"HPA058130":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.91e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"}},{"Gene":"CHKA","Gene synonym":["CHK","CKI"],"Ensembl":"ENSG00000110721","Gene description":"Choline kinase alpha","Uniprot":["P35790"],"Chromosome":"11","Position":"68052859-68121444","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"6.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"497725.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"1180206.9","salivary gland":"4040374.3","Stomach":"1710325.1"},"Antibody":["HPA024153","CAB072803"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":2,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB072803":null,"HPA024153":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"}},{"Gene":"CHMP3","Gene synonym":["CGI-149","NEDF","VPS24"],"Ensembl":"ENSG00000115561","Gene description":"Charged multivesicular body protein 3","Uniprot":["Q9Y3E7"],"Chromosome":"2","Position":"86503430-86563479","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis","Cell cycle","Cell division","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"443.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"443.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015673","HPA073383"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015673":null,"HPA073383":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.82e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"}},{"Gene":"CHPT1","Gene synonym":["CPT1"],"Ensembl":"ENSG00000111666","Gene description":"Choline phosphotransferase 1","Uniprot":["Q8WUD6"],"Chromosome":"12","Position":"101696947-101744140","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"1239.4","Salivary acinar cells":"703.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1239.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"basophil":"36.8","eosinophil":"14.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"36.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"126329.1","cerebral cortex":"205121.4","fallopian tube":"286909.9","salivary gland":"426401.6"},"Antibody":["HPA067643"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":6,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA067643":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.63e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"}},{"Gene":"CHRM2","Gene synonym":[],"Ensembl":"ENSG00000181072","Gene description":"Cholinergic receptor muscarinic 2","Uniprot":["P08172"],"Chromosome":"7","Position":"136868652-137020255","Protein class":["Disease related genes","FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"33.8","intestine":"19.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"56.0","Brain inhibitory neurons":"218.2","Cardiomyocytes":"545.5","Other brain neurons":"206.1","Retinal amacrine cells":"155.7","Smooth muscle cells":"101.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"545.5","Neuronal cells":"218.2","Smooth muscle cells":"101.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"1544.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"11.0"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatic stellate cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"7542.6"},"Antibody":["CAB022338","HPA029795"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB022338":null,"HPA029795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHRM4","Gene synonym":[],"Ensembl":"ENSG00000180720","Gene description":"Cholinergic receptor muscarinic 4","Uniprot":["P08173"],"Chromosome":"11","Position":"46383789-46391776","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.6","intestine":"5.8","lymphoid tissue":"14.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"6.2","Early spermatids":"2.5","Goblet cells":"14.8","Late primary spermatocytes":"8.0","Late spermatids":"10.0","Neuroendocrine cells":"3.5","Pancreatic islet cells":"5.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Goblet cells":"14.8","Neuronal cells":"6.2","Pancreatic islet cells":"5.8","Spermatogenic cell types":"10.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"basal ganglia":"44.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Skin - Keratinocyte (granular)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"basal ganglia":"22.1"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"27280.9"},"Antibody":["CAB022444","HPA072083"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Golgi apparatus","Plasma membrane","Primary cilium","Primary cilium tip"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Plasma membrane","Primary cilium","Primary cilium tip"],"Antibody RRID":{"CAB022444":null,"HPA072083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHRM5","Gene synonym":[],"Ensembl":"ENSG00000184984","Gene description":"Cholinergic receptor muscarinic 5","Uniprot":["P08912"],"Chromosome":"15","Position":"33968497-34067458","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"7.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"60.6","Cardiomyocytes":"78.1","Epicardial cells":"204.7","Extravillous trophoblasts":"41.1","Oligodendrocytes":"88.9","Other brain neurons":"44.0","Retinal bipolar cells":"68.5","Retinal ganglion cells":"42.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"204.7","Glial cells":"88.9","Myocytes":"78.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"130.6","oligodendrocyte":"137.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013172":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHRNA1","Gene synonym":["CHRNA"],"Ensembl":"ENSG00000138435","Gene description":"Cholinergic receptor nicotinic alpha 1 subunit","Uniprot":["P02708"],"Chromosome":"2","Position":"174747592-174787935","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["Congenital myasthenic syndrome","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"skeletal muscle":"160.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Myonuclei":"62.1","Myosatellite cells":"166.5","Thymic myoid cells":"55.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Myocytes":"62.1","Stem cells":"166.5","Stromal cells":"55.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"60.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"11.1"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"15","RNA brain regional specific nTPM":{"cerebral cortex":"27.1","hippocampal formation":"11.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"16","RNA cell line specific nTPM":{"Sarcoma":"107.0"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA071554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - 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Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Pancreas - Beta cells","Pituitary gland - Corticotropes","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"588","Protein cell type specific Intensity":{"Microglia and Neuropil":"93632.2","Neurons":"24049.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHRNB3","Gene synonym":[],"Ensembl":"ENSG00000147432","Gene description":"Cholinergic receptor nicotinic beta 3 subunit","Uniprot":["Q05901"],"Chromosome":"8","Position":"42697366-42737407","Protein class":["FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"2.5","pancreas":"1.7","retina":"3.5","testis":"1.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"7.7","Epicardial cells":"13.6","Other brain neurons":"5.4","Retinal amacrine cells":"30.0","Retinal ganglion cells":"69.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"69.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"mammillary body":"27.8","upper rhombic lip":"32.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.3"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"cerebellum":"25.9","midbrain":"22.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"Rhabdoid":"2.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHRNB4","Gene synonym":[],"Ensembl":"ENSG00000117971","Gene description":"Cholinergic receptor nicotinic beta 4 subunit","Uniprot":["P30926"],"Chromosome":"15","Position":"78624111-78727754","Protein class":["FDA approved drug targets","Predicted membrane proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"2.3","lymphoid tissue":"2.7","retina":"2.6","testis":"5.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"177.4","Late spermatids":"135.3","Oocytes":"152.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Oocytes":"152.0","Spermatogenic cell types":"177.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"6.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"35","RNA cell line specific nTPM":{"Neuroblastoma":"34.5"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"olfactory bulb":"5.3","pons and medulla":"1.4","thalamus":"4.2"},"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059484"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA059484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CHST1","Gene synonym":["C6ST","KSGal6ST"],"Ensembl":"ENSG00000175264","Gene description":"Carbohydrate sulfotransferase 1","Uniprot":["O43916"],"Chromosome":"11","Position":"45647689-45665622","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism","Inflammatory response"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"41.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"42.5","Astrocytes":"61.0","Bergmann glia":"22.7","Brain excitatory neurons":"25.7","Early spermatids":"66.0","Lacrimal acinar cells":"67.0","Late primary spermatocytes":"211.1","Other brain neurons":"24.4","Podocytes":"24.8","Salivary acinar cells":"22.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"67.0","Adrenal endocrine cells":"42.5","Glial cells":"61.0","Spermatogenic cell types":"211.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA060313":null,"HPA072592":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.39e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"CHST13","Gene synonym":["C4ST3"],"Ensembl":"ENSG00000180767","Gene description":"Carbohydrate sulfotransferase 13","Uniprot":["Q8NET6"],"Chromosome":"3","Position":"126524155-126543291","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"liver":"54.8","testis":"16.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"77.7","Late primary spermatocytes":"290.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"290.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer intratelencephalic":"1.2","hippocampal CA4":"1.5","hippocampal dentate gyrus":"1.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"29.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"eosinophil":"155.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"155.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"14.2"},"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Liver - Hepatocytes","Minor Salivary Gland - Macrophages","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"1330720.8","Macrophages":"1864897.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2390","Protein tissue specific Intensity":{"liver":"238954.1"},"Antibody":["HPA067960"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9300","Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA067960":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"}},{"Gene":"CHST8","Gene synonym":["GALNAC4ST-1"],"Ensembl":"ENSG00000124302","Gene description":"Carbohydrate sulfotransferase 8","Uniprot":["Q9H2A9"],"Chromosome":"19","Position":"33621953-33773509","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"brain":"17.4","pituitary gland":"61.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"157.8","Gonadotrophs":"217.8","Granulosa cells":"66.5","Lactotrophs":"473.0","Late spermatids":"132.7","Platelets":"69.1","Retinal ganglion cells":"123.6","Somatotrophs":"340.7","Thyrotrophs":"126.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"123.6","Pituitary endocrine cells":"473.0","Spermatogenic cell types":"132.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"181.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"9.1","Glioblastoma Multiforme (TCGA)":"11.8","Testicular Germ Cell Tumor (TCGA)":"6.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"12.0"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Beta cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016004"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":42,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016004":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CIAPIN1","Gene synonym":["CIAE2"],"Ensembl":"ENSG00000005194","Gene description":"Cytokine induced apoptosis inhibitor 1","Uniprot":["Q6FI81"],"Chromosome":"16","Position":"57428187-57447420","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"117.9","Early primary spermatocytes":"155.2","Late primary spermatocytes":"356.4","Oocytes":"142.8","Syncytiotrophoblasts":"132.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"356.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"20000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":17,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041350":null,"HPA042182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.52e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.22e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"}},{"Gene":"CIB1","Gene synonym":["CIB","KIP","SIP2-28"],"Ensembl":"ENSG00000185043","Gene description":"Calcium and integrin binding 1","Uniprot":["Q99828"],"Chromosome":"15","Position":"90229975-90234047","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Angiogenesis","Apoptosis","Cell adhesion","Cell cycle","Cell division","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"615.3","Fallopian tube ciliated cells":"911.2","Late spermatids":"2494.8","Respiratory ciliated cells":"963.3","Salivary duct cells":"645.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"963.3","Spermatogenic cell types":"2494.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"74.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2168590.5","Neutrophils":"1141557.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB012991","HPA042413","HPA048825","HPA074310"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":45,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"CAB012991":null,"HPA042413":null,"HPA048825":null,"HPA074310":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.34e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.69e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.07e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"}},{"Gene":"CIB2","Gene synonym":["DFNB48","KIP2","USH1J"],"Ensembl":"ENSG00000136425","Gene description":"Calcium and integrin binding family member 2","Uniprot":["O75838"],"Chromosome":"15","Position":"78104606-78131535","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Deafness","Disease variant","Non-syndromic deafness","Retinitis pigmentosa","Usher syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"46.8","lymphoid tissue":"44.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"501.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"501.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"48","RNA blood cell specific nTPM":{"plasmacytoid DC":"18.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"48","RNA blood lineage specific nTPM":{"dendritic cells":"18.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"45.5"},"RNA tissue cell type enrichment":["Skin - Inner root sheath cells","Skin - Outer root sheath cells","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"5755582.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036697"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Primary cilium transition zone","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium transition zone","Centrosome","Cytosol"],"Antibody RRID":{"HPA036697":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"}},{"Gene":"CIB4","Gene synonym":[],"Ensembl":"ENSG00000157884","Gene description":"Calcium and integrin binding family member 4","Uniprot":["A0PJX0"],"Chromosome":"2","Position":"26581205-26641366","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"16.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Adrenal cortex cells":"81.5","Early spermatids":"142.6","Late primary spermatocytes":"197.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"81.5","Spermatogenic cell types":"197.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"7.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"2.5","Thyroid Carcinoma (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036130","HPA036131"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036130":null,"HPA036131":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CIBAR1","Gene synonym":["BARMR1","FAM92A","FAM92A1","FLJ38979"],"Ensembl":"ENSG00000188343","Gene description":"CBY1 interacting BAR domain containing 1","Uniprot":["A1XBS5"],"Chromosome":"8","Position":"93698561-93731527","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"102.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1493.3","Late primary spermatocytes":"999.5","Late spermatids":"952.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1493.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"144.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"3.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"11062641.6","Oocytes":"15767481.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"16955","Protein tissue specific Intensity":{"fallopian tube":"1695537.0"},"Antibody":["HPA034760","HPA058942"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA034760":null,"HPA058942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.84e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.57e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.21e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"}},{"Gene":"CILP2","Gene synonym":["MGC45771"],"Ensembl":"ENSG00000160161","Gene description":"Cartilage intermediate layer protein 2","Uniprot":["Q8IUL8"],"Chromosome":"19","Position":"19538248-19546659","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"2.3","testis":"5.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"21.5","Late primary spermatocytes":"51.8","Late spermatids":"29.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"51.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"2.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":"4","RNA pig brain regional specific nTPM":{"medulla oblongata":"3.5","spinal cord":"9.6"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"35528406.8","Smooth muscle cells":"24401708.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"60777006.5","skeletal muscle":"47865235.8"},"Antibody":["HPA041847"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to extracellular matrix","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041847":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"}},{"Gene":"CINP","Gene synonym":["MGC849"],"Ensembl":"ENSG00000100865","Gene description":"Cyclin dependent kinase 2 interacting protein","Uniprot":["Q9BW66"],"Chromosome":"14","Position":"102341102-102362916","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA repair","DNA replication","Ribosome biogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"121.8","Late primary spermatocytes":"192.3","Late spermatids":"173.7","Oocytes":"133.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"192.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"2115796.6","Glomeruli":"2156807.7","Oocytes":"3674654.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"2323312.2"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":44,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.51e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"}},{"Gene":"CIP2A","Gene synonym":["KIAA1524"],"Ensembl":"ENSG00000163507","Gene description":"Cellular inhibitor of PP2A","Uniprot":["Q8TCG1"],"Chromosome":"3","Position":"108549864-108589644","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["DNA damage"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"48.6","Erythrocyte progenitors":"68.7","Late primary spermatocytes":"110.3","Megakaryocyte progenitors":"53.7","Monocyte progenitors":"119.1","Neutrophil progenitors":"87.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"68.7","Mononuclear phagocytes":"119.1","Neutrophils":"87.3","Spermatogenic cell types":"110.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1593707.2","Large ducts":"2233887.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"25016605.3","lymphoid tissue":"35468575.7"},"Antibody":["HPA039570"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":19,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane","Centrosome","Basal body"],"Antibody RRID":{"HPA039570":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.14e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.37e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.50e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"}},{"Gene":"CIR1","Gene synonym":["CIR"],"Ensembl":"ENSG00000138433","Gene description":"Corepressor interacting with RBPJ, CIR1","Uniprot":["Q86X95"],"Chromosome":"2","Position":"174348022-174395712","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing","Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"560.4","Neutrophils":"583.9","Oocytes":"580.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"583.9","Oocytes":"580.2","Spermatogenic cell types":"560.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"188.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"188.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"3022867.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015784","HPA061442"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":14,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA015784":null,"HPA061442":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"}},{"Gene":"CIROP","Gene synonym":["LMLN2"],"Ensembl":"ENSG00000283654","Gene description":"Ciliated left-right organizer metallopeptidase","Uniprot":["A0A1B0GTW7"],"Chromosome":"14","Position":"23099062-23104989","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Disease variant","Heterotaxy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"No human protein\/transcript evidence","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Epicardial cells":"2.3","Oligodendrocytes":"1.3","Platelets":"2.8","Retinal amacrine cells":"3.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"2.3","Glial cells":"1.3","Neuronal cells":"3.5","Platelets":"2.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"1.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CISD1","Gene synonym":["C10orf70","MDS029","mitoNEET","ZCD1"],"Ensembl":"ENSG00000122873","Gene description":"CDGSH iron sulfur domain 1","Uniprot":["Q9NZ45"],"Chromosome":"10","Position":"58269162-58289586","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"77.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"501.3","Gastric progenitor cells":"346.1","Late primary spermatocytes":"399.8","Late spermatids":"479.0","Parietal cells":"388.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"501.3","Spermatogenic cell types":"479.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":8,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA074383":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - 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Adrenal cortex cells","Colon - Enteric glia cells","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"20454031.5","Pancreas epithelial cells":"21057642.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"34034607.5"},"Antibody":["HPA019082","HPA048812","HPA075506"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":18,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019082":null,"HPA048812":null,"HPA075506":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.82e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.77e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.30e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"}},{"Gene":"CIZ1","Gene synonym":["LSFR1","ZNF356"],"Ensembl":"ENSG00000148337","Gene description":"CDKN1A interacting zinc finger protein 1","Uniprot":["Q9ULV3"],"Chromosome":"9","Position":"128161251-128204383","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Dystonia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"115.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"6005509.8","Neurons":"4977762.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"3573513.5"},"Antibody":["HPA020380","HPA020387"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA020380":null,"HPA020387":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"}},{"Gene":"CKLF","Gene synonym":["C32","CKLF1","CKLF3","CKLF4","HSPC224","UCK-1"],"Ensembl":"ENSG00000217555","Gene description":"Chemokine like factor","Uniprot":["Q9UBR5"],"Chromosome":"16","Position":"66552563-66566251","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Chemotaxis"],"Molecular function":["Cytokine"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"196.5","Early primary spermatocytes":"186.0","Gastric progenitor cells":"439.6","Hofbauer cells":"205.7","Late primary spermatocytes":"361.3","Mast cells":"258.9","Megakaryocytes":"210.2","Neutrophils":"399.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"399.4","Proliferating cells":"439.6","Spermatogenic cell types":"361.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"163.9","leukocyte":"171.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1394.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":31700,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA062779":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.29e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"}},{"Gene":"CKS2","Gene synonym":[],"Ensembl":"ENSG00000123975","Gene description":"CDC28 protein kinase regulatory subunit 2","Uniprot":["P33552"],"Chromosome":"9","Position":"89311195-89316703","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"167.0","testis":"175.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"609.6","Early primary spermatocytes":"577.8","Extravillous trophoblasts":"422.1","Gastric progenitor cells":"480.6","Granulosa cells":"440.4","Late primary spermatocytes":"1009.5","Migrating cytotrophoblasts":"346.0","Oocytes":"741.4","Undifferentiated spermatogonia":"337.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"741.4","Spermatogenic cell types":"1009.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"188.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2903","Protein cell type specific Intensity":{"Granulosa cells":"389024.3","Oocytes":"191525.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"8024136.2"},"Antibody":["HPA003424","HPA030762"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":26,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA003424":null,"HPA030762":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.86e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.78e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.45e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.99e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"CLBA1","Gene synonym":["C14orf79"],"Ensembl":"ENSG00000140104","Gene description":"Clathrin binding box of aftiphilin containing 1","Uniprot":["Q96F83"],"Chromosome":"14","Position":"104985775-105010482","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"36.6","Endometrial ciliated cells":"52.0","Fallopian tube ciliated cells":"54.0","Late primary spermatocytes":"47.9","Respiratory ciliated cells":"44.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"54.0","Spermatogenic cell types":"47.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"31.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042052","HPA061117","HPA078556"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA042052":null,"HPA061117":null,"HPA078556":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"}},{"Gene":"CLCA2","Gene synonym":["CLCRG2"],"Ensembl":"ENSG00000137975","Gene description":"Chloride channel accessory 2","Uniprot":["Q9UQC9"],"Chromosome":"1","Position":"86424171-86456553","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Cell adhesion","Ion transport","Transport"],"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"43.0","esophagus":"110.4","skin 1":"83.8","vagina":"53.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"124.1","Esophageal apical cells":"411.2","Esophageal basal cells":"217.0","Esophageal suprabasal cells":"480.0","Ocular epithelial cells":"204.0","Prostatic hillock cells":"155.5","Respiratory basal cells":"100.8","Respiratory deuterosomal cells":"85.0","Respiratory secretory cells":"172.7","Suprabasal keratinocytes":"216.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"411.2","Barrier epithelial cells":"204.0","Basal cells":"217.0","Secretory cells":"172.7","Suprabasal cells":"480.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"61.6","Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"121.1","Head and Neck Squamous Cell Carcinoma (TCGA)":"233.8","Lung Squamous Cell Carcinoma (TCGA)":"108.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"breast cancer":"24.6","Esophageal cancer":"13.5","Gallbladder cancer":"13.2","head and neck cancer":"29.1"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Urothelial cells","Skin - Mitotic cells (Skin)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"98017","Protein cell type specific Intensity":{"Keratinocytes":"9801661.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"33535","Protein tissue specific Intensity":{"skin":"3353472.2"},"Antibody":["HPA047192"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Cell Junctions"],"Secretome location":"Intracellular and membrane","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"54000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":null,"Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA047192":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.12e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CLCNKA","Gene synonym":["hClC-Ka"],"Ensembl":"ENSG00000186510","Gene description":"Chloride voltage-gated channel Ka","Uniprot":["P51800"],"Chromosome":"1","Position":"16018875-16034050","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel"],"Disease involvement":["Bartter syndrome","Deafness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"kidney":"332.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"160.5","Epididymal clear cells":"42.9","Gonadotrophs":"86.4","Late spermatids":"394.7","Loop of henle epithelial cells":"187.8","Renal collecting duct intercalated cells":"123.9","Renal connecting tubule cells":"99.9","Respiratory ionocytes":"40.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"123.9","Pituitary endocrine cells":"86.4","Renal nephron cells":"187.8","Spermatogenic cell types":"394.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"29.3","choroid plexus epithelial cell":"22.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"24","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"64.6"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"7","RNA brain regional specific nTPM":{"cerebellum":"3.9","choroid plexus":"9.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"thyroid cancer":"7.5"},"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary gland ductal cells","Pituitary gland - Gonadotropes","Skin - Eccrine sweat gland cells","Stomach - Parietal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"8309110.9","Large ducts":"4008499.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"271492.4","intestine":"322253.5"},"Antibody":["HPA057717"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057717":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CLDN16","Gene synonym":["HOMG3","PCLN1"],"Ensembl":"ENSG00000113946","Gene description":"Claudin 16","Uniprot":["Q9Y5I7"],"Chromosome":"3","Position":"190322541-190412138","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary hypomagnesemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"kidney":"59.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"83.1","Epicardial cells":"34.1","Epididymal basal cells":"122.2","Epididymal efferent duct ciliated cells":"66.7","Loop of henle epithelial cells":"89.9","Ocular epithelial cells":"194.0","Respiratory ciliated cells":"99.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"194.0","Basal cells":"122.2","Ciliated cells":"99.2","Renal nephron cells":"89.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"64.3"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"13","RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"68.9","Thyroid Carcinoma (TCGA)":"59.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"ovarian cancer":"120.3","Uterine cancer":"175.0"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal cortex cells","Kidney - Ascending Loop of Henle cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"17568","Protein cell type specific Intensity":{"Distal tubules":"1756785.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA056020"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056020":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"}},{"Gene":"CLDN17","Gene synonym":["MGC126552","MGC126554"],"Ensembl":"ENSG00000156282","Gene description":"Claudin 17","Uniprot":["P56750"],"Chromosome":"21","Position":"30165565-30166805","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"cervix":"6.4","esophagus":"6.1","salivary gland":"5.5","vagina":"6.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"21","RNA single cell type specific nCPM":{"Esophageal apical cells":"95.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"21","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"95.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"3.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"77","Protein tissue specific Intensity":{"intestine":"7721.5"},"Antibody":["HPA045903"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045903":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CLDN34","Gene synonym":[],"Ensembl":"ENSG00000234469","Gene description":"Claudin 34","Uniprot":["H7C241"],"Chromosome":"X","Position":"9967358-9968352","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"11.3","Late primary spermatocytes":"10.1","Late spermatids":"8.3","Retinal ganglion cells":"3.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Neuronal cells":"3.9","Spermatogenic cell types":"11.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CLDND1","Gene synonym":["C3orf4","Z38"],"Ensembl":"ENSG00000080822","Gene description":"Claudin domain containing 1","Uniprot":["Q9NY35"],"Chromosome":"3","Position":"98497912-98523066","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"brain":"1440.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"693.2","Extravillous trophoblasts":"235.1","Late primary spermatocytes":"267.7","Oligodendrocytes":"681.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"693.2","Glial cells":"681.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"911.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1249314.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"25154895.1"},"Antibody":["HPA029841"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA029841":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.53e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"}},{"Gene":"CLDND2","Gene synonym":["MGC33839"],"Ensembl":"ENSG00000160318","Gene description":"Claudin domain containing 2","Uniprot":["Q8NHS1"],"Chromosome":"19","Position":"51367098-51369003","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"43.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"19","RNA single cell type specific nCPM":{"Early spermatids":"263.8","Late primary spermatocytes":"282.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"43","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"282.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"1.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":24,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA056971":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.33e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":10,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035814":null,"HPA035815":null,"HPA061385":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.74e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"CLEC4F","Gene synonym":["CLECSF13","FLJ39110","KCLR"],"Ensembl":"ENSG00000152672","Gene description":"C-type lectin domain family 4 member F","Uniprot":["Q8N1N0"],"Chromosome":"2","Position":"70808643-70820599","Protein class":["Predicted membrane proteins"],"Biological process":["Endocytosis"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"16.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"22.3","Cone photoreceptor cells":"12.4","Macrophages":"7.1","monocytes":"2.8","Platelets":"2.8","Renal collecting duct intercalated cells":"3.6","Retinal ganglion cells":"7.7","Retinal horizontal cells":"4.0","Rod photoreceptor cells":"16.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"dendritic cells":"22.3","Mononuclear phagocytes":"7.1","Neuronal cells":"16.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"leukocyte":"4.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"intermediate monocyte":"6.0","non-classical monocyte":"4.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"monocytes":"6.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.5","lymphoma":"3.8"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA056101":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.56e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CLEC9A","Gene synonym":["CD370","DNGR-1","HEEE9341","UNQ9341"],"Ensembl":"ENSG00000197992","Gene description":"C-type lectin domain containing 9A","Uniprot":["Q6UXN8"],"Chromosome":"12","Position":"10030678-10066031","Protein class":["CD markers","Predicted membrane proteins"],"Biological process":["Endocytosis"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.1","lymphoid tissue":"7.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"cDC":"87.9","Hematopoietic stem cells":"50.0","Microglia":"114.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"dendritic cells":"87.9","Glial cells":"114.4","Stem cells":"50.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"35","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"137.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"4.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"96","RNA blood cell specific nTPM":{"myeloid DC":"22.0","neutrophil":"7.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"96","RNA blood lineage specific nTPM":{"dendritic cells":"22.0","granulocytes":"7.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"3.6","Myeloma":"3.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CLGN","Gene synonym":[],"Ensembl":"ENSG00000153132","Gene description":"Calmegin","Uniprot":["O14967"],"Chromosome":"4","Position":"140388453-140427661","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"55.7","testis":"106.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"156.6","Early spermatids":"104.9","Endometrial ciliated cells":"118.7","Fallopian tube ciliated cells":"165.3","Late primary spermatocytes":"756.8","Late spermatids":"70.4","M\u00fcller glia":"197.7","Prostatic glandular cells":"141.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"165.3","Glandular cells":"141.4","Glial cells":"197.7","Spermatogenic cell types":"756.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"31.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"40.4"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Pituitary gland - Lactotropes","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"14250759.9","Cardiomyocytes":"18721655.7","Fallopian tube cells":"5542927.7","Pancreatic islets":"16216763.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"9926550.6"},"Antibody":["CAB020709","HPA048761","HPA058627"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Equatorial segment","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":62,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Equatorial segment","Mid piece"],"Antibody RRID":{"CAB020709":null,"HPA048761":null,"HPA058627":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.53e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.80e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"}},{"Gene":"CLHC1","Gene synonym":["C2orf63","FLJ31438"],"Ensembl":"ENSG00000162994","Gene description":"Clathrin heavy chain linker domain containing 1","Uniprot":["Q8NHS4"],"Chromosome":"2","Position":"55172547-55232563","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"190.1","Ependymal cells":"229.8","Respiratory ciliated cells":"138.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"229.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"257.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Nucleoli fibrillar center","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA045418":null,"HPA053557":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.76e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"}},{"Gene":"CLIC5","Gene synonym":["DFNB102"],"Ensembl":"ENSG00000112782","Gene description":"Chloride intracellular channel 5","Uniprot":["Q9NZA1"],"Chromosome":"6","Position":"45880827-46080348","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Hearing","Ion transport","Sensory transduction","Transport","Vision"],"Molecular function":["Chloride channel","Ion channel","Oxidoreductase","Voltage-gated channel"],"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"96.2","skeletal muscle":"271.2","tongue":"91.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Alveolar cells type 1":"992.7","Podocytes":"3048.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Alveolar cells":"992.7","Renal nephron cells":"3048.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"endothelial cell":"204.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"26.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"5.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"T-cells":"5.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"11.2","ovarian cancer":"13.8"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"750000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 57: Podocytes - Glomerular filtration","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"HPA074371":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.59e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"}},{"Gene":"CLIP1","Gene synonym":["CLIP","CLIP-170","CLIP170","CYLN1","RSN"],"Ensembl":"ENSG00000130779","Gene description":"CAP-Gly domain containing linker protein 1","Uniprot":["P30622"],"Chromosome":"12","Position":"122271432-122422669","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"283.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1160.0","Myonuclei":"1170.5","Syncytiotrophoblasts":"1160.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1160.0","Myocytes":"1170.5","Trophoblast cells":"1160.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"83895062.6"},"Antibody":["CAB004399","HPA026678"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubule ends","Cytosol","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5000","Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":70,"Subcellular main location":["Microtubule ends","Mid piece"],"Subcellular additional location":["Cytosol","Principal piece"],"Antibody RRID":{"CAB004399":null,"HPA026678":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.56e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.50e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"CLIP4","Gene synonym":["FLJ21069","RSNL2"],"Ensembl":"ENSG00000115295","Gene description":"CAP-Gly domain containing linker protein family member 4","Uniprot":["Q8N3C7"],"Chromosome":"2","Position":"29097705-29199777","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"284.8","Podocytes":"577.9","Retinal pigment epithelial cells":"336.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"577.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"24.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"377315.8","Neurons":"675248.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043366","HPA056246"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":15,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA043366":null,"HPA056246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"}},{"Gene":"CLNK","Gene synonym":["MIST"],"Ensembl":"ENSG00000109684","Gene description":"Cytokine dependent hematopoietic cell linker","Uniprot":["Q7Z7G1"],"Chromosome":"4","Position":"10486395-10684768","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"6.1","lymphoid tissue":"2.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"312.8","Epididymal clear cells":"485.8","Renal collecting duct intercalated cells":"2616.1","Respiratory ionocytes":"1051.6","Salivary ionocytes":"879.7","Somatotrophs":"625.7","Thymocytes":"211.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"2616.1","Ionocytes":"1051.6","Pituitary endocrine cells":"625.7","Reproductive supporting cells":"485.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"15.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"23","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"63.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"3.4"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":9,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035671":null,"HPA035672":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"}},{"Gene":"CLPP","Gene synonym":[],"Ensembl":"ENSG00000125656","Gene description":"Caseinolytic mitochondrial matrix peptidase proteolytic subunit","Uniprot":["Q16740"],"Chromosome":"19","Position":"6361531-6370242","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":["Deafness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"214.8","Esophageal suprabasal cells":"169.9","Late spermatids":"313.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"313.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5700","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":237,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA010649":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"}},{"Gene":"CLPX","Gene synonym":[],"Ensembl":"ENSG00000166855","Gene description":"Caseinolytic mitochondrial matrix peptidase chaperone subunit X","Uniprot":["O76031"],"Chromosome":"15","Position":"65148219-65185342","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"218.5","Late spermatids":"423.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"423.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":19,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Cytosol","Equatorial segment","Perinuclear theca"],"Antibody RRID":{"HPA040262":null,"HPA048199":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.57e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"}},{"Gene":"CLTCL1","Gene synonym":["CHC22","CLH22","CLTCL","CLTD"],"Ensembl":"ENSG00000070371","Gene description":"Clathrin heavy chain like 1","Uniprot":["P53675"],"Chromosome":"22","Position":"19179473-19291719","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skeletal muscle":"180.9","testis":"45.3","tongue":"57.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"131.7","Myonuclei":"629.8","Neutrophil progenitors":"463.3","Retinal ganglion cells":"239.5","Somatotrophs":"147.2","Thymic myoid cells":"500.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"629.8","Neutrophils":"463.3","Stromal cells":"500.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"classical monocyte":"2.1","neutrophil":"5.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"20","RNA blood lineage specific nTPM":{"granulocytes":"5.2","monocytes":"2.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":13,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA075327":null,"HPA075795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.53e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.40e-4"}},{"Gene":"CLUAP1","Gene synonym":["CFAP22","FAP22","FLJ13297","IFT38","KIAA0643"],"Ensembl":"ENSG00000103351","Gene description":"Clusterin associated protein 1","Uniprot":["Q96AJ1"],"Chromosome":"16","Position":"3500976-3539048","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"163.4","Fallopian tube ciliated cells":"137.2","Late primary spermatocytes":"222.2","Respiratory ciliated cells":"218.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"218.0","Spermatogenic cell types":"222.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1254104.4","Fallopian tube cells":"3351883.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"43091","Protein tissue specific Intensity":{"fallopian tube":"4309141.4"},"Antibody":["HPA036976","HPA044191"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Actin filaments","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":46,"Subcellular main location":["Nucleoplasm","Primary cilium"],"Subcellular additional location":["Vesicles","Actin filaments"],"Antibody RRID":{"HPA036976":null,"HPA044191":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.33e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"}},{"Gene":"CLVS1","Gene synonym":["C6orf212L","CRALBPL","MGC34646","RLBP1L1"],"Ensembl":"ENSG00000177182","Gene description":"Clavesin 1","Uniprot":["Q8IUQ0"],"Chromosome":"8","Position":"61057158-61501645","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.6","retina":"4.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"145.3","Brain inhibitory neurons":"199.5","Corticotrophs":"141.2","Ependymal cells":"150.0","Gonadotrophs":"149.3","Lactotrophs":"147.3","M\u00fcller glia":"200.3","Oligodendrocyte progenitor cells":"123.6","Other brain neurons":"181.4","Retinal amacrine cells":"66.3","Retinal ganglion cells":"69.5","Somatotrophs":"72.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"150.0","Glial cells":"200.3","Neuronal cells":"199.5","Pituitary endocrine cells":"149.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"7.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.8","Neuroblastoma":"2.7"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA076650":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"}},{"Gene":"CLXN","Gene synonym":["EFCAB1","FLJ11767","ODAD5"],"Ensembl":"ENSG00000034239","Gene description":"Calaxin","Uniprot":["Q9HAE3"],"Chromosome":"8","Position":"48710789-48735311","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"choroid plexus":"51.3","fallopian tube":"86.1","testis":"35.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"621.6","Endometrial ciliated cells":"210.8","Ependymal cells":"268.0","Epididymal efferent duct ciliated cells":"347.5","Fallopian tube ciliated cells":"451.3","Late primary spermatocytes":"227.1","Late spermatids":"735.6","Respiratory ciliated cells":"517.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Ciliated cells":"517.7","Spermatogenic cell types":"735.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"30","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"103.8","ependymal cell":"312.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"13.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"2.9"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"70767","Protein cell type specific Intensity":{"Fallopian tube cells":"7076669.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"31975","Protein tissue specific Intensity":{"fallopian tube":"3197519.8"},"Antibody":["HPA023527"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023527":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.80e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"}},{"Gene":"CMC1","Gene synonym":["C3orf68","MGC61571"],"Ensembl":"ENSG00000187118","Gene description":"C-X9-C motif containing 1","Uniprot":["Q7Z7K0"],"Chromosome":"3","Position":"28241584-28325142","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"NK-cells":"491.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"NK-cells":"491.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"162.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Spleen - NK-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"2010391.1","kidney":"1106148.6"},"Antibody":["HPA043333"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043333":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.23e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"}},{"Gene":"CMC2","Gene synonym":["C16orf61","DC13","MGC45036"],"Ensembl":"ENSG00000103121","Gene description":"C-X9-C motif containing 2","Uniprot":["Q9NRP2"],"Chromosome":"16","Position":"80966448-81020270","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"77.9","Brain excitatory neurons":"95.0","Brain inhibitory neurons":"85.1","Distal convoluted tubule cells":"70.2","Early primary spermatocytes":"71.6","Late primary spermatocytes":"93.4","Late spermatids":"134.9","Oligodendrocyte progenitor cells":"80.9","Oligodendrocytes":"111.4","Other brain neurons":"84.7","Parietal cells":"88.4","Renal collecting duct intercalated cells":"73.3","Renal connecting tubule cells":"76.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"88.4","Glial cells":"111.4","Neuronal cells":"95.0","Spermatogenic cell types":"134.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"2924660.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"12275459.0","liver":"5281112.3"},"Antibody":["HPA006871","HPA007253","CAB026396"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB026396":null,"HPA006871":null,"HPA007253":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.18e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"}},{"Gene":"CMPK2","Gene synonym":["NDK","TYKi","UMP-CMPK2"],"Ensembl":"ENSG00000134326","Gene description":"Cytidine\/uridine monophosphate kinase 2","Uniprot":["Q5EBM0"],"Chromosome":"2","Position":"6840570-6866635","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Pyrimidine biosynthesis"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"6.1","salivary gland":"8.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"20.7","Fallopian tube ciliated cells":"18.6","Foveolar cells":"31.3","Hofbauer cells":"36.6","Kupffer cells":"35.9","Respiratory ciliated cells":"21.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"31.3","Mononuclear phagocytes":"36.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"33.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"8.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"5.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"5.7"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"4953128.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"9324302.0"},"Antibody":["HPA041430","HPA062191"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041430":null,"HPA062191":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CMSS1","Gene synonym":["C3orf26","MGC4308"],"Ensembl":"ENSG00000184220","Gene description":"Cms1 ribosomal small subunit homolog","Uniprot":["Q9BQ75"],"Chromosome":"3","Position":"99817837-100181732","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"1947.7","Ependymal cells":"1030.2","Epicardial cells":"777.8","Myonuclei":"2411.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1030.2","Myocytes":"2411.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"1170.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"897097.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"8155","Protein tissue specific Intensity":{"lymphoid tissue":"815549.3"},"Antibody":["HPA042820"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane","Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":30,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Nuclear membrane","Mitochondria"],"Antibody RRID":{"HPA042820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.06e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.21e-5"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA013801":null,"HPA017136":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.08e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"CMTM2","Gene synonym":["CKLFSF2","FLJ25732","MGC39436"],"Ensembl":"ENSG00000140932","Gene description":"CKLF like MARVEL transmembrane domain containing 2","Uniprot":["Q8TAZ6"],"Chromosome":"16","Position":"66579448-66588275","Protein class":["Predicted membrane proteins"],"Biological process":["Chemotaxis"],"Molecular function":["Cytokine"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"421","RNA tissue specific nTPM":{"testis":"616.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"3468.8","Late primary spermatocytes":"4321.6","Late spermatids":"3910.0","Neutrophils":"1005.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4321.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"neutrophil":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Heart muscle - Neutrophils","Lung - Neutrophils_2","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.09e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CMTR2","Gene synonym":["AFT","FLJ11171","FTSJD1","MTr2"],"Ensembl":"ENSG00000180917","Gene description":"Cap methyltransferase 2","Uniprot":["Q8IYT2"],"Chromosome":"16","Position":"71281389-71289715","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["mRNA capping","mRNA processing"],"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"22.2","Bergmann glia":"25.9","Choroid plexus epithelial cells":"34.7","Distal convoluted tubule cells":"36.0","Microglia":"54.7","Oligodendrocyte progenitor cells":"22.6","Oligodendrocytes":"24.6","Other brain neurons":"21.1","Podocytes":"20.4","Proximal tubule cells":"24.6","Renal collecting duct intercalated cells":"22.8","Renal connecting tubule cells":"23.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"34.7","Glial cells":"54.7","Renal nephron cells":"36.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":15,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"HPA041700":null,"HPA048265":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.93e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"CNBD1","Gene synonym":["FLJ35802"],"Ensembl":"ENSG00000176571","Gene description":"Cyclic nucleotide binding domain containing 1","Uniprot":["Q8NA66"],"Chromosome":"8","Position":"86866415-87615219","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"4.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"248.9","Late primary spermatocytes":"383.7","Late spermatids":"155.7","Retinal pigment epithelial cells":"375.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Pigment cells":"375.1","Spermatogenic cell types":"383.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"23.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA025037":null,"HPA027469":null,"HPA027786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNBD2","Gene synonym":["C20orf152","CNMPD1","dJ954P9.1"],"Ensembl":"ENSG00000149646","Gene description":"Cyclic nucleotide binding domain containing 2","Uniprot":["Q96M20"],"Chromosome":"20","Position":"35954564-36030700","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"24.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"353.2","Epididymal principal cells":"65.4","Late primary spermatocytes":"153.4","Late spermatids":"146.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"353.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043182"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Actin filaments","Cytosol","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoli","Mid piece"],"Subcellular additional location":["Actin filaments","Cytosol"],"Antibody RRID":{"HPA043182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"CNDP1","Gene synonym":["CN1","CPGL2","HsT2308","MGC10825"],"Ensembl":"ENSG00000150656","Gene description":"Carnosine dipeptidase 1","Uniprot":["Q96KN2"],"Chromosome":"18","Position":"74534500-74587212","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"56.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Oligodendrocytes":"739.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"739.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"32","RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"259.7","oligodendrocyte":"905.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"1.1"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":9400000000,"Blood concentration - Conc. blood MS [pg\/L]":"2500000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA008933":null,"HPA073283":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNGA3","Gene synonym":["ACHM2","CCNC1","CCNCa","CNCG3","CNG3"],"Ensembl":"ENSG00000144191","Gene description":"Cyclic nucleotide gated channel subunit alpha 3","Uniprot":["Q16281"],"Chromosome":"2","Position":"98346188-98398601","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Sensory transduction","Sodium transport","Transport","Vision"],"Molecular function":["Calcium channel","Ion channel","Ligand-gated ion channel","Sodium channel"],"Disease involvement":["Disease variant","Leber congenital amaurosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"4.7","intestine":"5.1","pituitary gland":"10.0","retina":"5.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"16.2","Cone photoreceptor cells":"43.5","Early spermatids":"12.1","Lactotrophs":"57.5","Late primary spermatocytes":"14.2","Late spermatids":"11.5","Other brain neurons":"11.5","Somatotrophs":"40.3","Thyrotrophs":"43.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"16.2","Neuronal cells":"43.5","Pituitary endocrine cells":"57.5","Spermatogenic cell types":"14.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"11.5","choroid plexus epithelial cell":"10.8","ependymal cell":"10.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"15.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Neuroblastoma":"1.5"},"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Lung - Respiratory ciliated cells","Pancreas - Alpha cells","Pancreas - Beta cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"6","RNA mouse brain regional specific nTPM":{"basal ganglia":"1.8","hypothalamus":"1.9"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"402","Protein cell type specific Intensity":{"Smooth muscle cells":"40156.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049378","CAB079025"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Approved","Subcellular location":["Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":1,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"CAB079025":null,"HPA049378":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.79e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNGA4","Gene synonym":["CNCA2","CNG5","CNGB2","OCNC2","OCNCb"],"Ensembl":"ENSG00000132259","Gene description":"Cyclic nucleotide gated channel subunit alpha 4","Uniprot":["Q8IV77"],"Chromosome":"11","Position":"6234765-6244479","Protein class":["Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Olfaction","Sensory transduction","Transport"],"Molecular function":["Calcium channel","Ion channel","Ligand-gated ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"fallopian tube":"16.2","testis":"5.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"21.5","Cone photoreceptor cells":"16.6","Early spermatids":"20.0","Ependymal cells":"18.9","Epididymal basal cells":"20.3","Erythrocyte progenitors":"18.9","Fallopian tube ciliated cells":"16.5","Late primary spermatocytes":"22.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"22.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"20.8"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"256","Protein tissue specific Intensity":{"fallopian tube":"15859.1","intestine":"39539.9","ovary":"21318.3"},"Antibody":["HPA074128"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":10,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA074128":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"}},{"Gene":"CNGB3","Gene synonym":["ACHM1","ACHM3","RMCH"],"Ensembl":"ENSG00000170289","Gene description":"Cyclic nucleotide gated channel subunit beta 3","Uniprot":["Q9NQW8"],"Chromosome":"8","Position":"86553977-86743675","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Sensory transduction","Transport","Vision"],"Molecular function":["Ion channel","Ligand-gated ion channel"],"Disease involvement":["Disease variant","Stargardt disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"3.9","retina":"11.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Cardiomyocytes":"297.5","Cone photoreceptor cells":"855.0","Retinal pigment epithelial cells":"771.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Myocytes":"297.5","Neuronal cells":"855.0","Pigment cells":"771.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"29.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057244":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNIH2","Gene synonym":["CNIH-2","Cnil","MGC50896"],"Ensembl":"ENSG00000174871","Gene description":"Cornichon family AMPA receptor auxiliary protein 2","Uniprot":["Q6PI25"],"Chromosome":"11","Position":"66278175-66285301","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"brain":"424.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"37.0","Brain inhibitory neurons":"32.7","Early spermatids":"82.0","Ependymal cells":"24.7","Late primary spermatocytes":"50.6","Late spermatids":"34.2","Neuroendocrine cells":"24.0","Other brain neurons":"52.0","Pancreatic islet cells":"107.8","Respiratory ciliated cells":"31.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"31.8","Neuronal cells":"52.0","Pancreatic islet cells":"107.8","Spermatogenic cell types":"82.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"130.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"39.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"11.9"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.26e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":29,"Subcellular main location":["Actin filaments"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA017732":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.12e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.27e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.80e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.58e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"CNOT10","Gene synonym":["FLJ12890","FLJ13165"],"Ensembl":"ENSG00000182973","Gene description":"CCR4-NOT transcription complex subunit 10","Uniprot":["Q9H9A5"],"Chromosome":"3","Position":"32685145-32773875","Protein class":["Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing","Transcription","Transcription regulation","Translation regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035614","HPA041450"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":26,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035614":null,"HPA041450":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.65e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.43e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.57e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"}},{"Gene":"CNOT11","Gene synonym":["C2orf29","C40"],"Ensembl":"ENSG00000158435","Gene description":"CCR4-NOT transcription complex subunit 11","Uniprot":["Q9UKZ1"],"Chromosome":"2","Position":"101252886-101270316","Protein class":["Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing","Transcription","Transcription regulation","Translation regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"657202.6","Oocytes":"1437734.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"85000.9","lung":"319712.2","lymphoid tissue":"102204.5","salivary gland":"85946.2"},"Antibody":["HPA069823","HPA074943"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":58,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA069823":null,"HPA074943":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"}},{"Gene":"CNPY3","Gene synonym":["CAG4A","TNRC5"],"Ensembl":"ENSG00000137161","Gene description":"Canopy FGF signaling regulator 3","Uniprot":["Q9BT09"],"Chromosome":"6","Position":"42929480-42939294","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":["Chaperone"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"253.1","Hofbauer cells":"344.4","Kupffer cells":"182.4","monocytes":"199.6","Neutrophils":"215.2","pDCs":"281.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"281.6","Mononuclear phagocytes":"344.4","Trophoblast cells":"253.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"129.5","leukocyte":"49.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"4696169.5"},"Antibody":["HPA016560"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Plasma membrane"],"Secretome location":"Intracellular and membrane","Secretome function":"Immunity","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":38,"Subcellular main location":["Endoplasmic reticulum","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA016560":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"}},{"Gene":"CNTD1","Gene synonym":["CNTD","FLJ40137"],"Ensembl":"ENSG00000176563","Gene description":"Cyclin N-terminal domain containing 1","Uniprot":["Q8N815"],"Chromosome":"17","Position":"42798800-42811587","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"39.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"159.6","Early spermatids":"61.3","Gastric chief cells":"55.7","Late primary spermatocytes":"181.0","Late spermatids":"174.3","Mucous neck cells":"54.7","Parietal cells":"111.4","Respiratory ciliated cells":"50.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"111.4","Spermatogenic cell types":"181.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA072363"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA072363":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":16,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA019654":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"71000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA001397":null,"HPA012497":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNTN4","Gene synonym":["BIG-2"],"Ensembl":"ENSG00000144619","Gene description":"Contactin 4","Uniprot":["Q8IWV2"],"Chromosome":"3","Position":"2098813-3057959","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"21.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"779.0","Brain inhibitory neurons":"845.6","Lactotrophs":"1420.6","Medullary thymic epithelial cells":"1024.9","Pituicytes\/FSCs":"1263.3","Pituitary stem cells":"2322.6","Podocytes":"677.0","Retinal amacrine cells":"757.9","Retinal bipolar cells":"1297.8","Retinal horizontal cells":"2341.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1263.3","Neuronal cells":"2341.9","Pituitary endocrine cells":"1420.6","Stem cells":"2322.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"5.2","Rhabdoid":"5.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"23000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNTN6","Gene synonym":["NB-3"],"Ensembl":"ENSG00000134115","Gene description":"Contactin 6","Uniprot":["Q9UQ52"],"Chromosome":"3","Position":"1092658-1404217","Protein class":["Predicted membrane proteins"],"Biological process":["Cell adhesion","Notch signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"3.2","brain":"8.8","thyroid gland":"9.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"444.8","Alveolar cells type 1":"224.0","Brain excitatory neurons":"185.8","Brain inhibitory neurons":"73.4","Oligodendrocyte progenitor cells":"80.2","Oocytes":"69.1","Other brain neurons":"72.3","Pituicytes\/FSCs":"144.9","Retinal amacrine cells":"67.6","Transitional alveolar cells":"79.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"444.8","Alveolar cells":"224.0","Glial cells":"144.9","Neuronal cells":"185.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"532.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"15","RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"11.5","Thyroid Carcinoma (TCGA)":"5.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"1.5","thyroid cancer":"1.9"},"RNA tissue cell type enrichment":["Lung - 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Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.74e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7600000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031859":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CNTRL","Gene synonym":["CEP1","CEP110"],"Ensembl":"ENSG00000119397","Gene description":"Centriolin","Uniprot":["Q7Z7A1"],"Chromosome":"9","Position":"121074660-121177729","Protein class":["Cancer-related genes","Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"20.3","testis":"28.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"406.1","Ependymal cells":"253.1","Fallopian tube ciliated cells":"257.8","Late primary spermatocytes":"401.9","Monocyte progenitors":"413.7","Neutrophil progenitors":"332.1","Respiratory ciliated cells":"315.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"413.7","Spermatogenic cell types":"406.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":5,"Subcellular main location":["Centrosome","Basal body","Flagellar centriole"],"Subcellular additional location":["Golgi apparatus","Plasma membrane","Centriolar satellite","Cytosol"],"Antibody RRID":{"HPA020468":null,"HPA020480":null,"HPA051583":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"}},{"Gene":"CNTROB","Gene synonym":["LIP8","PP1221"],"Ensembl":"ENSG00000170037","Gene description":"Centrobin, centriole duplication and spindle assembly protein","Uniprot":["Q8N137"],"Chromosome":"17","Position":"7932101-7949920","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"72.7","Early primary spermatocytes":"49.2","Late primary spermatocytes":"47.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Stromal cells":"72.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":20,"Subcellular main location":["Centrosome","Basal body","Flagellar centriole"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023319":null,"HPA023320":null,"HPA023321":null,"HPA023325":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"COA4","Gene synonym":["CHCHD8","CMC3","E2IG2"],"Ensembl":"ENSG00000181924","Gene description":"Cytochrome c oxidase assembly factor 4 homolog","Uniprot":["Q9NYJ1"],"Chromosome":"11","Position":"73872667-73876901","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"250.8","Gastric progenitor cells":"261.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"108","Protein cell type specific Intensity":{"Proximal tubules":"10778.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040126"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5100","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":2,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA040126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.37e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.47e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"}},{"Gene":"COA8","Gene synonym":["APOP-1","APOPT1","C14orf153","MGC2562"],"Ensembl":"ENSG00000256053","Gene description":"Cytochrome c oxidase assembly factor 8","Uniprot":["Q96IL0"],"Chromosome":"14","Position":"103562960-103607523","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"114.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"285.1","Late primary spermatocytes":"116.3","Late spermatids":"574.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"574.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.07e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"}},{"Gene":"COG8","Gene synonym":["DOR1","FLJ22315"],"Ensembl":"ENSG00000213380","Gene description":"Component of oligomeric golgi complex 8","Uniprot":["Q96MW5"],"Chromosome":"16","Position":"69320140-69339583","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Congenital disorder of glycosylation"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"43.4","Epicardial cells":"52.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"52.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"4645470.0"},"Antibody":["HPA041406","HPA049429"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":22,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA041406":null,"HPA049429":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.51e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.26e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.15e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.52e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"}},{"Gene":"COIL","Gene synonym":["CLN80","p80-coilin"],"Ensembl":"ENSG00000121058","Gene description":"Coilin","Uniprot":["P38432"],"Chromosome":"17","Position":"56938199-56961050","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"92.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"223.7","Late primary spermatocytes":"267.2","Late spermatids":"905.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"905.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":109,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm","Nucleoli fibrillar center"],"Antibody RRID":{"CAB017524":null,"CAB069400":null,"HPA027885":null,"HPA068537":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.17e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.84e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"}},{"Gene":"COL11A1","Gene synonym":["CO11A1","COLL6","DFNA37","STL2"],"Ensembl":"ENSG00000060718","Gene description":"Collagen type XI alpha 1 chain","Uniprot":["P12107"],"Chromosome":"1","Position":"102876467-103108872","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Cataract","Deafness","Disease variant","Dwarfism","Ectodermal dysplasia","Non-syndromic deafness","Stickler syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"18.9","retina":"8.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"91.8","Brain inhibitory neurons":"90.1","M\u00fcller glia":"99.1","Oligodendrocyte progenitor cells":"684.0","Oligodendrocytes":"161.0","Pituicytes\/FSCs":"432.5","Pituitary stem cells":"202.4","Retinal amacrine cells":"159.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"684.0","Neuronal cells":"159.6","Stem cells":"202.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"855.2","oligodendrocyte precursor cell":"815.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"32.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"252.9"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"540000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA058335":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.28e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.84e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.66e-8"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"COL22A1","Gene synonym":[],"Ensembl":"ENSG00000169436","Gene description":"Collagen type XXII alpha 1 chain","Uniprot":["Q8NFW1"],"Chromosome":"8","Position":"138588235-138914041","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"pituitary gland":"40.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"74.5","Bergmann glia":"230.1","Early spermatids":"66.2","Epididymal basal cells":"50.1","Gonadotrophs":"411.7","Lactotrophs":"101.0","Late spermatids":"52.3","M\u00fcller glia":"93.2","Oocytes":"96.7","Pituitary stem cells":"73.2","Somatotrophs":"49.4","Thyrotrophs":"203.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"230.1","Oocytes":"96.7","Pituitary endocrine cells":"411.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"226.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Breast - T-cells","Colon - Enteric glia cells","Minor Salivary Gland - Minor salivary glandular cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"1651001.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"4317623.6"},"Antibody":["HPA024830"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Vesicles"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 20: Pituitary gland - Hormone signaling","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA024830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.75e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.75e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.33e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.44e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.01e-6"}},{"Gene":"COL25A1","Gene synonym":[],"Ensembl":"ENSG00000188517","Gene description":"Collagen type XXV alpha 1 chain","Uniprot":["Q9BXS0"],"Chromosome":"4","Position":"108808725-109302752","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Heparin-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"20.3","testis":"16.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Pituicytes\/FSCs":"9594.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Glial cells":"9594.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"930.6","mammillary body":"849.5","medium spiny neuron":"694.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"4.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":1,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA029107":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.33e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.70e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"}},{"Gene":"COL2A1","Gene synonym":["AOM","SEDC","STL1"],"Ensembl":"ENSG00000139219","Gene description":"Collagen type II alpha 1 chain","Uniprot":["P02458"],"Chromosome":"12","Position":"47972967-48004554","Protein class":["Cancer-related genes","Disease related genes","FDA approved drug targets","Human disease related genes","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Cataract","Deafness","Disease variant","Dwarfism","FDA approved drug targets","Stickler syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"epididymis":"18.0","pituitary gland":"8.8","retina":"5.2","stomach 1":"11.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"15.4","Epididymal principal cells":"58.3","Gonadotrophs":"41.0","Granulosa cells":"19.5","M\u00fcller glia":"26.2","Neuroendocrine cells":"42.7","Parietal cells":"127.3","Pituitary stem cells":"18.6","Retinal amacrine cells":"41.6","Tuft cells":"34.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enteroendocrine cells":"42.7","Gastric glandular cells":"127.3","Neuronal cells":"41.6","Pituitary endocrine cells":"41.0","Reproductive supporting cells":"58.3","Secretory gland support":"34.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"2.8","hippocampal dentate gyrus":"5.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"22.3","Prostate Adenocarcinoma (TCGA)":"19.7","Skin Cutaneous Melanoma (TCGA)":"14.8","Testicular Germ Cell Tumor (TCGA)":"22.7","Uterine Corpus Endometrial Carcinoma (TCGA)":"8.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"liver cancer":"78.5"},"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"1678676.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"22822072.9"},"Antibody":["CAB002214","HPA055753"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"No annotated function","CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB002214":null,"HPA055753":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"COL6A5","Gene synonym":["COL29A1","FLJ35880","VWA4"],"Ensembl":"ENSG00000172752","Gene description":"Collagen type VI alpha 5 chain","Uniprot":[],"Chromosome":"3","Position":"130345516-130484846","Protein class":["Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lung":"5.5","skin 1":"4.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"8.4","Erythrocyte progenitors":"3.3","Fibroblasts":"3.7","Late primary spermatocytes":"4.9","Late spermatids":"12.1","Megakaryocyte-Erythroid progenitors":"10.4","Other brain neurons":"5.7","Undifferentiated spermatogonia":"8.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Erythrocytes":"3.3","Fibroblasts":"3.7","Megakaryocytes":"10.4","Neuronal cells":"5.7","Spermatogenic cell types":"12.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"29","RNA single nuclei brain specific nCPM":{"thalamic excitatory":"27.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"midbrain":"3.3","thalamus":"1.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"lymphoma":"4.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":null,"Protein cell type distribution":null,"Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":null,"Protein tissue distribution":null,"Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043138"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"55000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA074749":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":144,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA034633":null,"HPA049223":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.41e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.84e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"}},{"Gene":"COMMD3","Gene synonym":["BUP","C10orf8"],"Ensembl":"ENSG00000148444","Gene description":"COMM domain containing 3","Uniprot":["Q9UBI1"],"Chromosome":"10","Position":"22316386-22320306","Protein class":["Predicted intracellular proteins"],"Biological process":["Ion transport","Sodium transport","Transcription","Transcription regulation","Transport","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"290.1","Late primary spermatocytes":"81.5","Late spermatids":"67.1","Parietal cells":"54.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"290.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":45,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036584":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":92,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"HPA039935":null,"HPA066957":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":61,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035887":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.09e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"}},{"Gene":"COMP","Gene synonym":["EDM1","EPD1","MED","PSACH","THBS5"],"Ensembl":"ENSG00000105664","Gene description":"Cartilage oligomeric matrix protein","Uniprot":["P49747"],"Chromosome":"19","Position":"18782773-18791305","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Apoptosis","Cell adhesion"],"Molecular function":["Heparin-binding"],"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"blood vessel":"333.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"35.2","Endometrial glandular cells":"61.6","Epididymal basal cells":"205.9","Epididymal principal cells":"21.2","Fibroblasts":"76.4","Late primary spermatocytes":"56.7","Late spermatids":"148.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Basal cells":"205.9","Fibroblasts":"76.4","Glandular cells":"61.6","Spermatogenic cell types":"148.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"109.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"2.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Bladder cancer":"6.7","Gastric cancer":"4.2","ovarian cancer":"12.3","Rhabdoid":"5.1"},"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1400000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":7,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA077555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - 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Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052552"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA052552":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.68e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"}},{"Gene":"COPS3","Gene synonym":["CSN3","SGN3"],"Ensembl":"ENSG00000141030","Gene description":"COP9 signalosome subunit 3","Uniprot":["Q9UNS2"],"Chromosome":"17","Position":"17246616-17281273","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"359.6","Oocytes":"221.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"359.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"29135107.4"},"Antibody":["HPA021997","HPA050557"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"95000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":138,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021997":null,"HPA050557":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"}},{"Gene":"COPS5","Gene synonym":["CSN5","JAB1","MOV-34","SGN5"],"Ensembl":"ENSG00000121022","Gene description":"COP9 signalosome subunit 5","Uniprot":["Q92905"],"Chromosome":"8","Position":"67043079-67083783","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"453.3","Late primary spermatocytes":"387.5","Late spermatids":"757.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"757.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":241,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB004242":null,"HPA004845":null,"HPA051531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.36e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.16e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.64e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":25,"Subcellular main location":["Nucleoli","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA049487":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.72e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.98e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"}},{"Gene":"COQ6","Gene synonym":["CGI-10"],"Ensembl":"ENSG00000119723","Gene description":"Coenzyme Q6, monooxygenase","Uniprot":["Q9Y2Z9"],"Chromosome":"14","Position":"73949926-73963670","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubiquinone biosynthesis"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Deafness","Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"219.4","Late spermatids":"64.5","Myonuclei":"62.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"62.8","Spermatogenic cell types":"219.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"112692574.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"29253841.8"},"Antibody":["HPA051371"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051371":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"}},{"Gene":"COQ9","Gene synonym":["C16orf49","DKFZP434K046"],"Ensembl":"ENSG00000088682","Gene description":"Coenzyme Q9","Uniprot":["O75208"],"Chromosome":"16","Position":"57447425-57461270","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Ubiquinone biosynthesis"],"Molecular function":null,"Disease involvement":["Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"239.3","tongue":"225.2"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"226135536.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"253238672.9","skeletal muscle":"150442315.0"},"Antibody":["HPA040918"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":46,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040918":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.65e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.69e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.95e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"}},{"Gene":"CORT","Gene synonym":["MGC32686","SST2"],"Ensembl":"ENSG00000241563","Gene description":"Cortistatin","Uniprot":["O00230"],"Chromosome":"1","Position":"10450031-10451998","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"33","RNA tissue specific nTPM":{"brain":"66.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"2.2","Brain inhibitory neurons":"15.7","Early spermatids":"4.3","Ependymal cells":"2.6","Hepatic stellate cells":"6.5","Late primary spermatocytes":"5.1","Late spermatids":"8.1","Oligodendrocytes":"1.9","Other brain neurons":"3.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"15.7","Spermatogenic cell types":"8.1","Stellate cells":"6.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"MGE interneuron":"67.7","splatter":"109.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"}},{"Gene":"COX10","Gene synonym":[],"Ensembl":"ENSG00000006695","Gene description":"Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10","Uniprot":["Q12887"],"Chromosome":"17","Position":"14069490-14231736","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Heme biosynthesis","Lipid metabolism"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Leigh syndrome","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"40.5","tongue":"41.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"191.3","Late spermatids":"181.4","Myonuclei":"158.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"191.3","Spermatogenic cell types":"181.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA032005":null,"HPA032006":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"}},{"Gene":"COX5A","Gene synonym":[],"Ensembl":"ENSG00000178741","Gene description":"Cytochrome c oxidase subunit 5A","Uniprot":["P20674"],"Chromosome":"15","Position":"74919791-74938083","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"1666.8","skeletal muscle":"1561.5","tongue":"1618.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"1154.4","Enteric stem cells":"1034.6","Enteric transient amplifying cells":"1176.7","Enterocytes":"1107.1","Esophageal apical cells":"2058.2","Esophageal suprabasal cells":"1112.9","Late primary spermatocytes":"1221.0","Late spermatids":"1085.7","Parietal cells":"1967.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2058.2","Gastric glandular cells":"1967.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"200000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":33,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA027526":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.41e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA062394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"}},{"Gene":"COX6B2","Gene synonym":["COXVIB2","CT59","FLJ32865"],"Ensembl":"ENSG00000160471","Gene description":"Cytochrome c oxidase subunit 6B2","Uniprot":["Q6YFQ2"],"Chromosome":"19","Position":"55349306-55354719","Protein class":["Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"87.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"7.9","Early primary spermatocytes":"27.6","Early spermatids":"13.2","Late primary spermatocytes":"65.2","Respiratory deuterosomal cells":"6.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"65.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"3.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"12.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035014":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"67000","Blood expression cluster":"Cluster 6: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":19,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB016244":null,"HPA014295":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.23e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"COX8C","Gene synonym":["COX8-3"],"Ensembl":"ENSG00000187581","Gene description":"Cytochrome c oxidase subunit 8C","Uniprot":["Q7Z4L0"],"Chromosome":"14","Position":"93347182-93348356","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"189","RNA tissue specific nTPM":{"testis":"71.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"50.2","Early primary spermatocytes":"175.1","Early spermatids":"327.9","Late primary spermatocytes":"192.1","Late spermatids":"865.5","Oocytes":"96.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"865.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Lung Squamous Cell Carcinoma (TCGA)":"1.1","Ovary Serous Cystadenocarcinoma (TCGA)":"3.6","Testicular Germ Cell Tumor (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA003127":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CPA5","Gene synonym":[],"Ensembl":"ENSG00000158525","Gene description":"Carboxypeptidase A5","Uniprot":["Q8WXQ8"],"Chromosome":"7","Position":"130344816-130368730","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"30.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"258.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"258.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"mammillary body":"1.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory CD4 T-cell":"16.9","naive CD8 T-cell":"42.6","T-reg":"56.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"101","RNA blood lineage specific nTPM":{"T-cells":"56.6"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"26","RNA cell line specific nTPM":{"Sarcoma":"27.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA020322":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CPA6","Gene synonym":["CPAH"],"Ensembl":"ENSG00000165078","Gene description":"Carboxypeptidase A6","Uniprot":["Q8N4T0"],"Chromosome":"8","Position":"67422038-67746378","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"2.2","prostate":"2.6","retina":"2.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal prostatic cells":"683.9","Colonocytes":"228.4","Enteric stem cells":"263.0","Enteric transient amplifying cells":"207.6","M\u00fcller glia":"503.4","Prostatic club cells":"937.5","Prostatic hillock cells":"1177.7","Urothelial cells":"143.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1177.7","Basal cells":"683.9","Glandular cells":"937.5","Glial cells":"503.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"101.8","midbrain-derived inhibitory":"94.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"1.5","liver cancer":"1.9"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CPD","Gene synonym":["GP180"],"Ensembl":"ENSG00000108582","Gene description":"Carboxypeptidase D","Uniprot":["O75976"],"Chromosome":"17","Position":"30378927-30469989","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Neutrophils":"3285.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Neutrophils":"3285.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"443.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"25.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1200000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA052796":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.88e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA072513":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CPLX2","Gene synonym":["CPX-2","DKFZp547D155"],"Ensembl":"ENSG00000145920","Gene description":"Complexin 2","Uniprot":["Q6PUV4"],"Chromosome":"5","Position":"175796310-175884021","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Exocytosis","Mast cell degranulation","Neurogenesis","Neurotransmitter transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"461.7","epididymis":"121.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"53.2","Brain excitatory neurons":"109.1","Brain inhibitory neurons":"67.3","Corticotrophs":"82.7","Early spermatids":"48.4","Epididymal principal cells":"95.9","Gonadotrophs":"53.9","Lactotrophs":"74.6","Late spermatids":"131.4","Neuroendocrine cells":"39.1","Other brain neurons":"77.2","Pancreatic islet cells":"122.5","Retinal amacrine cells":"126.0","Retinal horizontal cells":"76.1","Somatotrophs":"80.6","Thyrotrophs":"68.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"126.0","Pancreatic islet cells":"122.5","Pituitary endocrine cells":"82.7","Reproductive supporting cells":"95.9","Spermatogenic cell types":"131.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"44.8","Neuroblastoma":"66.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":5,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA071191":null,"HPA074390":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"}},{"Gene":"CPNE8","Gene synonym":[],"Ensembl":"ENSG00000139117","Gene description":"Copine 8","Uniprot":["Q86YQ8"],"Chromosome":"12","Position":"38646822-38907430","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Lymphatic endothelial cells":"304.3","Podocytes":"864.4","Vascular endothelial cells":"401.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"864.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"566.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Lung - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"7453791.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2927593.3"},"Antibody":["HPA038600"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038600":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.99e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.60e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.00e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.62e-4"}},{"Gene":"CPS1","Gene synonym":["GATD6"],"Ensembl":"ENSG00000021826","Gene description":"Carbamoyl-phosphate synthase 1","Uniprot":["P31327"],"Chromosome":"2","Position":"210477682-210679107","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Urea cycle"],"Molecular function":["Allosteric enzyme","Ligase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"994.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"20","RNA single cell type specific nCPM":{"Hepatocytes":"2626.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Hepatocytes":"2626.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"45.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"16","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"133.0","Lung Adenocarcinoma (TCGA)":"39.0","Stomach Adenocarcinoma (TCGA)":"34.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"121.4"},"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Kidney - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"11367000368.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"6202872108.8"},"Antibody":["CAB003781","HPA021400"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Nucleoli rim","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":4,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"CAB003781":null,"HPA021400":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.37e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.38e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"}},{"Gene":"CPSF3","Gene synonym":["CPSF-73","CPSF73","YSH1"],"Ensembl":"ENSG00000119203","Gene description":"Cleavage and polyadenylation specific factor 3","Uniprot":["Q9UKF6"],"Chromosome":"2","Position":"9423651-9473101","Protein class":["Disease related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing"],"Molecular function":["Endonuclease","Hydrolase","Nuclease","Ribonucleoprotein","RNA-binding"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"114.7","Early spermatids":"156.7","Late primary spermatocytes":"366.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"366.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Macrophages","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"7562549.0"},"Antibody":["HPA034657"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.98e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.33e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.12e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"CPT1B","Gene synonym":["CPT1-M","M-CPT1"],"Ensembl":"ENSG00000205560","Gene description":"Carnitine palmitoyltransferase 1B","Uniprot":["Q92523"],"Chromosome":"22","Position":"50568861-50578465","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism","Transport"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"heart muscle":"226.2","skeletal muscle":"136.9","testis":"75.9","tongue":"212.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"12.8","Bergmann glia":"6.8","Brain excitatory neurons":"7.5","Brain inhibitory neurons":"10.6","Ependymal cells":"5.5","Epididymal efferent duct ciliated cells":"5.5","Foveolar cells":"14.8","Late primary spermatocytes":"5.8","Late spermatids":"21.4","Microglia":"5.5","Oligodendrocyte progenitor cells":"7.1","Oligodendrocytes":"12.1","Other brain neurons":"5.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"14.8","Glial cells":"12.8","Neuronal cells":"10.6","Spermatogenic cell types":"21.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"57.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"138772979.1","Cardiomyocytes":"239428940.2","Skeletal myofibers":"139909467.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"108317456.5","skeletal muscle":"53939650.3"},"Antibody":["HPA079265"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA079265":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.21e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.86e-5"}},{"Gene":"CPTP","Gene synonym":["GLTPD1","MGC10334"],"Ensembl":"ENSG00000224051","Gene description":"Ceramide-1-phosphate transfer protein","Uniprot":["Q5TA50"],"Chromosome":"1","Position":"1324756-1328896","Protein class":["Predicted intracellular proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"82.0","Early spermatids":"66.3","Enterocytes":"65.5","Esophageal apical cells":"272.7","Esophageal suprabasal cells":"67.2","Late primary spermatocytes":"137.3","Late spermatids":"286.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"272.7","Spermatogenic cell types":"286.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"536497.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"616799.3"},"Antibody":["HPA056832"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol","Perinuclear theca","Flagellar centriole","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":null,"Subcellular main location":["Cytosol","Flagellar centriole","Mid piece"],"Subcellular additional location":["Perinuclear theca"],"Antibody RRID":{"HPA056832":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.56e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"}},{"Gene":"CPXCR1","Gene synonym":["CT77"],"Ensembl":"ENSG00000147183","Gene description":"CPX chromosome region candidate 1","Uniprot":["Q8N123"],"Chromosome":"X","Position":"88747225-88754785","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"52","RNA tissue specific nTPM":{"testis":"6.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"70.9","Late primary spermatocytes":"74.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"79","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"74.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"24000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA043249":null,"HPA048148":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB005337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.21e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"}},{"Gene":"CRAT","Gene synonym":["CAT1"],"Ensembl":"ENSG00000095321","Gene description":"Carnitine O-acetyltransferase","Uniprot":["P43155"],"Chromosome":"9","Position":"129094142-129111189","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Fatty acid metabolism","Lipid metabolism","Transport"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"206.8","tongue":"188.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"191.2","Enterocytes":"142.3","Esophageal apical cells":"123.9","Late primary spermatocytes":"299.2","Late spermatids":"977.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"977.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"432770076.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"164873122.4"},"Antibody":["HPA019230","HPA020260","HPA022815"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4300","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019230":null,"HPA020260":null,"HPA022815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.96e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.16e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.15e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"}},{"Gene":"CRBN","Gene synonym":["MRT2","MRT2A"],"Ensembl":"ENSG00000113851","Gene description":"Cereblon","Uniprot":["Q96SW2"],"Chromosome":"3","Position":"3144628-3179727","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Transporters"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"340.3","Oocytes":"350.0","Platelets":"337.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"350.0","Platelets":"337.4","Spermatogenic cell types":"340.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"309.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045910"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":56,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045910":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.75e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"}},{"Gene":"CREB1","Gene synonym":[],"Ensembl":"ENSG00000118260","Gene description":"CAMP responsive element binding protein 1","Uniprot":["P16220"],"Chromosome":"2","Position":"207529737-207605988","Protein class":["Cancer-related genes","Disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Differentiation","Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"620.7","Neutrophils":"618.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"618.2","Spermatogenic cell types":"620.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"9563996.5","T-cells":"13798318.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"18236141.8"},"Antibody":["CAB003803","HPA019150","HPA072073"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":54,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Basal body","Cytosol"],"Antibody RRID":{"CAB003803":null,"HPA019150":null,"HPA072073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.47e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"CREB3","Gene synonym":["Luman","LZIP","sLZIP"],"Ensembl":"ENSG00000107175","Gene description":"CAMP responsive element binding protein 3","Uniprot":["O43889"],"Chromosome":"9","Position":"35732598-35736999","Protein class":["Predicted membrane proteins","Transcription factors"],"Biological process":["Chemotaxis","Host-virus interaction","Transcription","Transcription regulation","Unfolded protein response"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"192.7","Late spermatids":"692.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"692.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate glandular cells","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030978","HPA077421"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Plasma membrane","Primary cilium","Primary cilium tip","Primary cilium transition zone","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":48,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles","Plasma membrane","Primary cilium","Primary cilium tip","Primary cilium transition zone","Centrosome","Basal body"],"Antibody RRID":{"HPA030978":null,"HPA077421":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.54e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.80e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.08e-6"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"}},{"Gene":"CREM","Gene synonym":["hCREM-2"],"Ensembl":"ENSG00000095794","Gene description":"CAMP responsive element modulator","Uniprot":["Q03060"],"Chromosome":"10","Position":"35126791-35212958","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"194.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"2296.4","Late primary spermatocytes":"1684.7","Late spermatids":"1024.5","Mast cells":"724.0","Neutrophils":"739.9","NK-cells":"691.5","pDCs":"804.0","T-cells":"873.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2296.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"130763.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001818","CAB018352"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB018352":null,"HPA001818":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.09e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"}},{"Gene":"CRH","Gene synonym":["CRF","CRH1"],"Ensembl":"ENSG00000147571","Gene description":"Corticotropin releasing hormone","Uniprot":["P06850"],"Chromosome":"8","Position":"66176376-66178464","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"brain":"52.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Pancreatic islet cells":"148.3","Syncytiotrophoblasts":"249.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Pancreatic islet cells":"148.3","Trophoblast cells":"249.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"CGE interneuron":"168.6","LAMP5-LHX6 and Chandelier":"52.1","thalamic excitatory":"81.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"63.7"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"medulla oblongata":"317.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"17","RNA cell line specific nTPM":{"Rhabdoid":"960.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"84278.1","Pancreatic islets":"105562.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"12177","Protein tissue specific Intensity":{"cerebral cortex":"1537691.3","Stomach":"897670.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Hormone","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":10000,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 13: Syncytiotrophoblasts - Placental remodeling & endocrine func.","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CRIP3","Gene synonym":["bA480N24.2","TLP","TLP-A"],"Ensembl":"ENSG00000146215","Gene description":"Cysteine rich protein 3","Uniprot":["Q6Q6R5"],"Chromosome":"6","Position":"43299710-43308826","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"15.2","heart muscle":"22.8","testis":"24.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"7.2","Bergmann glia":"5.9","Brain inhibitory neurons":"4.3","Cardiomyocytes":"8.1","cDC":"4.3","Cholangiocytes":"5.9","Early primary spermatocytes":"4.7","Ependymal cells":"4.0","Epididymal efferent duct absorptive cells":"4.8","Late primary spermatocytes":"7.2","Late spermatids":"14.3","Oligodendrocyte progenitor cells":"7.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"7.2","Myocytes":"8.1","Spermatogenic cell types":"14.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"11.5","Liver Hepatocellular Carcinoma (TCGA)":"13.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"16","RNA blood cell specific nTPM":{"myeloid DC":"44.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"16","RNA blood lineage specific nTPM":{"dendritic cells":"44.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"3.7"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA036198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"}},{"Gene":"CRISP1","Gene synonym":["AEGL1","ARP","CRISP-1","HSCRISP1D","HSCRISP1G","HUMARP"],"Ensembl":"ENSG00000124812","Gene description":"Cysteine rich secretory protein 1","Uniprot":["P54107"],"Chromosome":"6","Position":"49834257-49877096","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"epididymis":"1486.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Epididymal principal cells":"940.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"940.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028445","HPA030534"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028445":null,"HPA030534":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CRISP2","Gene synonym":["CRISP-2","CT36","GAPDL5","TPX1"],"Ensembl":"ENSG00000124490","Gene description":"Cysteine rich secretory protein 2","Uniprot":["P16562"],"Chromosome":"6","Position":"49692358-49713590","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"testis":"482.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"40585.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"681","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"40585.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"2.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"1.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Intercalated cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Pancreas - Ductal cells","Pituitary gland - Corticotropes","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031248"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1700000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031248":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CRPPA","Gene synonym":["hCG_1745121","ISPD","Nip"],"Ensembl":"ENSG00000214960","Gene description":"CDP-L-ribitol pyrophosphorylase A","Uniprot":["A4D126"],"Chromosome":"7","Position":"16087525-16502504","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":["Congenital muscular dystrophy","Disease variant","Dystroglycanopathy","Limb-girdle muscular dystrophy","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"8.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1329.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"1329.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1374.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"29","RNA blood cell specific nTPM":{"basophil":"13.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"29","RNA blood lineage specific nTPM":{"granulocytes":"13.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"3015713.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"287692.6"},"Antibody":["HPA053554"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":null,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA053554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.47e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.44e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"}},{"Gene":"CRYBA2","Gene synonym":[],"Ensembl":"ENSG00000163499","Gene description":"Crystallin beta A2","Uniprot":["P53672"],"Chromosome":"2","Position":"218990189-218993422","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Eye lens protein"],"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"16.2","pituitary gland":"13.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"26","RNA single cell type specific nCPM":{"Neuroendocrine cells":"938.2","Pancreatic islet cells":"1063.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"26","RNA single cell type group specific nCPM":{"Enteroendocrine cells":"938.2","Pancreatic islet cells":"1063.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"lower rhombic lip":"5.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"21","RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"50.8"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"midbrain":"23.4","pons":"10.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"4.7","Neuroblastoma":"4.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Prostate - Prostate glandular cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"pons and medulla":"4.3"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"14723","Protein cell type specific Intensity":{"Pancreatic islets":"1472324.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA062293"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA062293":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":2,"Subcellular main location":["Nucleoplasm","Microtubules","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB026378":null,"HPA030948":null,"HPA030949":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.66e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.38e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA075635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":11,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB034129":null,"HPA019120":null,"HPA029399":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.91e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"61000","Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":26,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Endoplasmic reticulum","Golgi apparatus","Plasma membrane"],"Antibody RRID":{"HPA018846":null,"HPA052221":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.14e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.39e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"}},{"Gene":"CSMD1","Gene synonym":["KIAA1890","PPP1R24"],"Ensembl":"ENSG00000183117","Gene description":"CUB and Sushi multiple domains 1","Uniprot":["Q96PZ7"],"Chromosome":"8","Position":"2935353-4994972","Protein class":["Plasma proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"4.0","retina":"1.4","testis":"2.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"4078.4","Brain inhibitory neurons":"4301.0","Conjunctival goblet cells":"1040.8","Oligodendrocyte progenitor cells":"7057.9","Other brain neurons":"2052.0","Sertoli cells":"2669.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"7057.9","Neuronal cells":"4301.0","Reproductive supporting cells":"2669.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA029007":null,"HPA029008":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":467,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"}},{"Gene":"CSNK2B","Gene synonym":["Ckb1","Ckb2"],"Ensembl":"ENSG00000204435","Gene description":"Casein kinase 2 beta","Uniprot":["P67870"],"Chromosome":"6","Position":"31665227-31670343","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"331.2","Esophageal apical cells":"306.2","Gastric progenitor cells":"289.7","Late primary spermatocytes":"720.3","Oocytes":"308.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"720.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"429.0"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"6211074.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004349","HPA005944","CAB013087","CAB016059","HPA070343"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Perinuclear theca","Calyx","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"71000","Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":399,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Perinuclear theca","Calyx","Mid piece"],"Antibody RRID":{"CAB004349":null,"CAB013087":null,"CAB016059":null,"HPA005944":null,"HPA070343":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"}},{"Gene":"CSNKA2IP","Gene synonym":[],"Ensembl":"ENSG00000283434","Gene description":"Casein kinase 2 subunit alpha' interacting protein","Uniprot":["A0A1B0GTH6"],"Chromosome":"3","Position":"88338416-88467594","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"219","RNA tissue specific nTPM":{"testis":"21.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"163.2","Late primary spermatocytes":"99.5","Late spermatids":"414.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"61","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"414.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CSPG5","Gene synonym":["NGC"],"Ensembl":"ENSG00000114646","Gene description":"Chondroitin sulfate proteoglycan 5","Uniprot":["O95196"],"Chromosome":"3","Position":"47562238-47580792","Protein class":["Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Differentiation","Growth regulation","Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"20","RNA tissue specific nTPM":{"brain":"103.3","choroid plexus":"53.4","retina":"26.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"53.6","Astrocytes":"83.5","Choroid plexus epithelial cells":"49.0","M\u00fcller glia":"107.8","Oligodendrocyte progenitor cells":"318.5","Other brain neurons":"39.3","Respiratory ionocytes":"55.9","Retinal pigment epithelial cells":"225.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"318.5","Pigment cells":"225.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"315.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"18","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"165.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"14.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1706679.9","Microglia and Neuropil":"3358444.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"101835","Protein tissue specific Intensity":{"cerebral cortex":"10183537.4"},"Antibody":["HPA071779","HPA076601"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles","Plasma membrane","Cytosol"],"Secretome location":"Secreted in brain","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":5,"Subcellular main location":["Golgi apparatus","Vesicles","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA071779":null,"HPA076601":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.58e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1993246.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"64232","Protein tissue specific Intensity":{"fallopian tube":"6423173.8"},"Antibody":["HPA056174"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Primary cilium","Centriolar satellite","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":10,"Subcellular main location":["Centriolar satellite","Centrosome","Basal body"],"Subcellular additional location":["Vesicles","Primary cilium"],"Antibody RRID":{"HPA056174":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.51e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045617":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"}},{"Gene":"CSTF1","Gene synonym":[],"Ensembl":"ENSG00000101138","Gene description":"Cleavage stimulation factor subunit 1","Uniprot":["Q05048"],"Chromosome":"20","Position":"56392371-56406362","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"108.8","Oocytes":"101.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"101.3","Spermatogenic cell types":"108.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":22,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB019270":null,"HPA047275":null,"HPA065000":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.28e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"}},{"Gene":"CSTPP1","Gene synonym":["C11orf49","FLJ22210","MGC4707"],"Ensembl":"ENSG00000149179","Gene description":"Centriolar satellite-associated tubulin polyglutamylase complex regulator 1","Uniprot":["Q9H6J7"],"Chromosome":"11","Position":"46936689-47164385","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"592.2","Respiratory ciliated cells":"554.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"592.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Skin - Keratinocyte (other)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"833366.5","Neurons":"452214.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3895","Protein tissue specific Intensity":{"fallopian tube":"389482.9"},"Antibody":["HPA040051","HPA040280"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":5,"Subcellular main location":["Primary cilium","Basal body","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040051":null,"HPA040280":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.59e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"}},{"Gene":"CT83","Gene synonym":["CXorf61","FLJ20611","FLJ22913","KK-LC-1"],"Ensembl":"ENSG00000204019","Gene description":"Cancer\/testis antigen 83","Uniprot":["Q5H943"],"Chromosome":"X","Position":"116461686-116462976","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"25","RNA tissue specific nTPM":{"testis":"66.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"4893.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"272","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4893.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"15.9","Stomach Adenocarcinoma (TCGA)":"13.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"37.9"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CTDP1","Gene synonym":["FCP1"],"Ensembl":"ENSG00000060069","Gene description":"CTD phosphatase subunit 1","Uniprot":["Q9Y5B0"],"Chromosome":"18","Position":"79679803-79754503","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Cataract","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"78.4","Late primary spermatocytes":"83.8","Neutrophils":"147.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"147.6","Spermatogenic cell types":"83.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"4263420.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"8459666.6"},"Antibody":["CAB032641","HPA040394","HPA070389"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 18: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB032641":null,"HPA040394":null,"HPA070389":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.72e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"CTNNA2","Gene synonym":["CAP-R","CT114"],"Ensembl":"ENSG00000066032","Gene description":"Catenin alpha 2","Uniprot":["P26232"],"Chromosome":"2","Position":"79185231-80648861","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell adhesion","Differentiation"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"88.2","epididymis":"63.3","retina":"74.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"4909.1","Brain excitatory neurons":"1496.6","Brain inhibitory neurons":"1505.5","Ependymal cells":"2811.9","Lactotrophs":"1020.6","M\u00fcller glia":"3578.2","Oligodendrocyte progenitor cells":"1929.3","Other brain neurons":"1832.8","Pituitary stem cells":"1217.0","Retinal ganglion cells":"1263.1","Sertoli cells":"1950.8","Somatotrophs":"1078.2","Thyrotrophs":"1652.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2811.9","Glial cells":"4909.1","Neuronal cells":"1832.8","Pituitary endocrine cells":"1652.5","Reproductive supporting cells":"1950.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"42.1","Kidney Chromophobe (TCGA)":"11.6","Uterine Corpus Endometrial Carcinoma (TCGA)":"11.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"96","RNA blood cell specific nTPM":{"basophil":"55.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"558","RNA blood lineage specific nTPM":{"granulocytes":"55.7"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"cervical cancer":"7.4","Myeloma":"8.7","Neuroblastoma":"23.0"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"30156541.6","Macrophages":"28026644.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"122270562.1"},"Antibody":["CAB037175"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB037175":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"}},{"Gene":"CTNNA3","Gene synonym":["MGC26194","VR22"],"Ensembl":"ENSG00000183230","Gene description":"Catenin alpha 3","Uniprot":["Q9UI47"],"Chromosome":"10","Position":"65912457-67763637","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":["Cardiomyopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"13.7","tongue":"14.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Bergmann glia":"2992.1","Cardiomyocytes":"3863.2","Myonuclei":"5423.3","Oligodendrocytes":"5017.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Glial cells":"5017.4","Myocytes":"5423.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"2815.9","oligodendrocyte":"7394.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Colon - Enteric glia cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"42719609.8","Cardiomyocytes":"93586238.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"57612020.6"},"Antibody":["HPA061818"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA061818":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.70e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CTNNBIP1","Gene synonym":["ICAT","MGC15093"],"Ensembl":"ENSG00000178585","Gene description":"Catenin beta interacting protein 1","Uniprot":["Q9NSA3"],"Chromosome":"1","Position":"9848276-9910336","Protein class":["Predicted intracellular proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"168.6","skin 1":"410.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Esophageal apical cells":"3781.6","Esophageal suprabasal cells":"1436.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"3781.6","Suprabasal cells":"1436.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"13.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Endothelial cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary gland basal cells","Prostate - Prostate glandular cells","Skin - Keratinocyte (granular)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"7878918.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"18007230.1"},"Antibody":["HPA067089"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":23,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA067089":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.90e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.04e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.50e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"}},{"Gene":"CTNNBL1","Gene synonym":["C20orf33","FLJ21108","NAP","NYD-SP19","P14","P14L"],"Ensembl":"ENSG00000132792","Gene description":"Catenin beta like 1","Uniprot":["Q8WYA6"],"Chromosome":"20","Position":"37693955-37872129","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Adaptive immunity","Immunity","mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"410.9","Late primary spermatocytes":"279.0","Mast cells":"513.8","Megakaryocyte-Erythroid progenitors":"461.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mast cells":"513.8","Megakaryocytes":"461.3","Spermatogenic cell types":"410.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA004742","HPA027906","HPA027907"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":60,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"HPA004742":null,"HPA027906":null,"HPA027907":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.07e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"}},{"Gene":"CTNND2","Gene synonym":["GT24","NPRAP"],"Ensembl":"ENSG00000169862","Gene description":"Catenin delta 2","Uniprot":["Q9UQB3"],"Chromosome":"5","Position":"10971836-11904446","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell adhesion","Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":["Autism","Autism spectrum disorder","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"72.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"4013.2","Bergmann glia":"3618.1","Brain excitatory neurons":"1243.8","Brain inhibitory neurons":"1098.2","Choroid plexus epithelial cells":"945.3","Lactotrophs":"776.6","Oligodendrocyte progenitor cells":"2053.7","Oligodendrocytes":"920.0","Other brain neurons":"880.8","Pituicytes\/FSCs":"1102.3","Retinal amacrine cells":"856.5","Retinal ganglion cells":"726.2","Somatotrophs":"1227.7","Thyrotrophs":"911.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"945.3","Glial cells":"4013.2","Neuronal cells":"1243.8","Pituitary endocrine cells":"1227.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"16","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"58.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"5.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Breast - Breast glandular cells","Lung - Alveolar cells type 1","Prostate - Prostate glandular cells","Skin - Outer root sheath cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"31760533.6","Microglia and Neuropil":"39670728.9","Neurons":"11527555.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"38282734.5"},"Antibody":["HPA015077","CAB037339","HPA071124"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cell Junctions","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":4,"Subcellular main location":["Nucleoplasm","Cell Junctions"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB037339":null,"HPA015077":null,"HPA071124":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"}},{"Gene":"CTNS","Gene synonym":["CTNS-LSB","PQLC4","SLC66A4"],"Ensembl":"ENSG00000040531","Gene description":"Cystinosin, lysosomal cystine transporter","Uniprot":["O60931"],"Chromosome":"17","Position":"3636459-3663103","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Melanin biosynthesis","Protein transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"100.7","Epicardial cells":"104.6","Platelets":"134.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"104.6","Myocytes":"100.7","Platelets":"134.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"34.3","granulocytes":"28.2","monocytes":"10.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate basal glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA074687"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA074687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8200000","Blood expression cluster":"Cluster 27: T-cells - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Endoplasmic reticulum","Plasma membrane"],"Antibody RRID":{"CAB002141":null,"HPA031431":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.95e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":241,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"CAB002676":null,"HPA029882":null,"HPA064584":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.25e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"}},{"Gene":"CUL2","Gene synonym":[],"Ensembl":"ENSG00000108094","Gene description":"Cullin 2","Uniprot":["Q13617"],"Chromosome":"10","Position":"35008504-35127006","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"417.8","Late primary spermatocytes":"181.5","Late spermatids":"290.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"417.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"10846950.2"},"Antibody":["CAB002677","HPA024578"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"14000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":136,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB002677":null,"HPA024578":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.30e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"}},{"Gene":"CUL3","Gene synonym":[],"Ensembl":"ENSG00000036257","Gene description":"Cullin 3","Uniprot":["Q13618"],"Chromosome":"2","Position":"224470150-224585397","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Cilium biogenesis\/degradation","ER-Golgi transport","Mitosis","Transport","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Autism spectrum disorder","Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"193.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"728.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB002678","HPA072059"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Microtubules","Cytokinetic bridge"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"69000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":858,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Microtubules","Cytokinetic bridge"],"Antibody RRID":{"CAB002678":null,"HPA072059":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.06e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.36e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"}},{"Gene":"CUTC","Gene synonym":["CGI-32"],"Ensembl":"ENSG00000119929","Gene description":"CutC copper transporter","Uniprot":["Q9NTM9"],"Chromosome":"10","Position":"99702558-99756134","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skeletal muscle":"361.4","tongue":"190.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"191.1","Late primary spermatocytes":"185.8","Myonuclei":"339.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"339.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"16920720.6","Skeletal myofibers":"20994179.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"7598394.7","skeletal muscle":"11663068.4"},"Antibody":["HPA038619","HPA058231"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":15,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA038619":null,"HPA058231":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-3"}},{"Gene":"CUX2","Gene synonym":["CDP2","CUTL2","KIAA0293"],"Ensembl":"ENSG00000111249","Gene description":"Cut like homeobox 2","Uniprot":["O14529"],"Chromosome":"12","Position":"111034165-111350554","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.7","choroid plexus":"10.3","liver":"19.7","prostate":"10.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1328.7","Hepatocytes":"629.0","pDCs":"576.9","Prostatic glandular cells":"760.8","Retinal amacrine cells":"615.7","Retinal horizontal cells":"571.0","Thymic myoid cells":"720.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1328.7","dendritic cells":"576.9","Glandular cells":"760.8","Hepatocytes":"629.0","Neuronal cells":"615.7","Stromal cells":"720.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"984.0","mammillary body":"524.1","upper-layer intratelencephalic":"516.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"7.1","Prostate Adenocarcinoma (TCGA)":"17.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"70","RNA blood cell specific nTPM":{"plasmacytoid DC":"7.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"70","RNA blood lineage specific nTPM":{"dendritic cells":"7.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"8.6","lymphoma":"7.0","Neuroblastoma":"13.8"},"RNA tissue cell type enrichment":["Pituitary gland - Corticotropes","Prostate - Prostate glandular cells","Skin - Sebaceous gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"379","Protein cell type specific Intensity":{"Neurons":"37862.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"236","Protein tissue specific Intensity":{"lung":"23583.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CWC15","Gene synonym":["AD002","C11orf5","Cwf15","HSPC148"],"Ensembl":"ENSG00000150316","Gene description":"CWC15 spliceosome associated protein homolog","Uniprot":["Q9P013"],"Chromosome":"11","Position":"94962620-94973586","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"922.7","Late primary spermatocytes":"642.2","Oocytes":"552.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"552.6","Spermatogenic cell types":"922.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"11245090.8"},"Antibody":["HPA039878"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":50,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA039878":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.78e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.46e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"CWC25","Gene synonym":["CCDC49","FLJ20291"],"Ensembl":"ENSG00000273559","Gene description":"CWC25 spliceosome associated protein homolog","Uniprot":["Q9NXE8"],"Chromosome":"17","Position":"38800441-38825355","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"58.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"78.3","Oocytes":"73.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"28.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"110532.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"24","Protein tissue specific Intensity":{"bone marrow":"2649.8","lymphoid tissue":"2234.0"},"Antibody":["CAB014874","HPA062997"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":3,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB014874":null,"HPA062997":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"CWC27","Gene synonym":["NY-CO-10","SDCCAG-10","SDCCAG10"],"Ensembl":"ENSG00000153015","Gene description":"CWC27 spliceosome associated cyclophilin","Uniprot":["Q6UX04"],"Chromosome":"5","Position":"64766368-65102412","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Dwarfism","Intellectual disability","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"412.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"412.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"3340883.6","Neurons":"2332774.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"4540494.9"},"Antibody":["HPA020344","HPA024149","HPA065809"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA020344":null,"HPA024149":null,"HPA065809":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.75e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.60e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.67e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.17e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"}},{"Gene":"CWF19L1","Gene synonym":["FLJ10998","hDrn1"],"Ensembl":"ENSG00000095485","Gene description":"CWF19 like cell cycle control factor 1","Uniprot":["Q69YN2"],"Chromosome":"10","Position":"100232298-100267680","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"3196297.6"},"Antibody":["HPA036889","HPA036890"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":11,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA036889":null,"HPA036890":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.96e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"}},{"Gene":"CXorf58","Gene synonym":["FLJ25444"],"Ensembl":"ENSG00000165182","Gene description":"Chromosome X open reading frame 58","Uniprot":["Q96LI9"],"Chromosome":"X","Position":"23908006-23939509","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"3.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"10.8","Early primary spermatocytes":"29.1","Early spermatids":"21.3","Hematopoietic stem cells":"9.7","Late primary spermatocytes":"42.4","Late spermatids":"9.1","Undifferentiated spermatogonia":"11.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"42.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"6.6","leukocyte":"8.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031542","HPA031543","HPA031544"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA031542":null,"HPA031543":null,"HPA031544":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CXorf66","Gene synonym":["RP11-35F15.2","SGPX"],"Ensembl":"ENSG00000203933","Gene description":"Chromosome X open reading frame 66","Uniprot":["Q5JRM2"],"Chromosome":"X","Position":"139955728-139965521","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"22","RNA tissue specific nTPM":{"testis":"12.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"135.4","Late primary spermatocytes":"95.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"272","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"135.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":9,"Subcellular main location":["Perinuclear theca","Calyx","Annulus"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA048517":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CXXC5","Gene synonym":["HSPC195","RINF","WID"],"Ensembl":"ENSG00000171604","Gene description":"CXXC finger protein 5","Uniprot":["Q7LFL8"],"Chromosome":"5","Position":"139647299-139683882","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"146.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"770.3","Esophageal apical cells":"296.2","Late primary spermatocytes":"311.8","Late spermatids":"250.5","Retinal horizontal cells":"288.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"770.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"MAIT T-cell":"30.1","memory B-cell":"85.4","naive B-cell":"97.1","NK-cell":"72.1","plasmacytoid DC":"59.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036508":null,"HPA058148":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"}},{"Gene":"CYB5D2","Gene synonym":["MGC32124"],"Ensembl":"ENSG00000167740","Gene description":"Cytochrome b5 domain containing 2","Uniprot":["Q8WUJ1"],"Chromosome":"17","Position":"4143168-4187310","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Neurogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"226.2","Platelets":"149.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"226.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"79897.3","Distal tubules":"200105.8","Microglia and Neuropil":"167988.6","Neurons":"218091.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"257","Protein tissue specific Intensity":{"cerebral cortex":"25729.0"},"Antibody":["HPA011032","HPA042299"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Plasma membrane"],"Secretome location":"Secreted to blood","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":12,"Subcellular main location":["Endoplasmic reticulum","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA011032":null,"HPA042299":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.52e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.65e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.53e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.33e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"}},{"Gene":"CYB5R2","Gene synonym":[],"Ensembl":"ENSG00000166394","Gene description":"Cytochrome b5 reductase 2","Uniprot":["Q6BCY4"],"Chromosome":"11","Position":"7665100-7677222","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Steroid biosynthesis","Steroid metabolism","Sterol biosynthesis","Sterol metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"129.1","testis":"127.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"248.3","Late primary spermatocytes":"297.7","Late spermatids":"1009.7","Rod photoreceptor cells":"70.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1009.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"10.8","oligodendrocyte":"17.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"eosinophil":"6.1","memory B-cell":"10.6","naive B-cell":"2.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"B-cells":"10.6","granulocytes":"6.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Spleen - Fibroblasts_1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"7085052.2"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038962","HPA061707"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":6,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA038962":null,"HPA061707":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018992":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Calyx"],"Subcellular additional location":["Perinuclear theca"],"Antibody RRID":{"HPA070355":null,"HPA078303":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Calyx"],"Subcellular additional location":["Perinuclear theca"],"Antibody RRID":{"HPA062456":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":141,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":["Nucleoplasm","Primary cilium transition zone","Basal body","Principal piece"],"Antibody RRID":{"CAB011713":null,"HPA050095":null,"HPA077163":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.60e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":17,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB000355":null,"HPA051194":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CYP26C1","Gene synonym":[],"Ensembl":"ENSG00000187553","Gene description":"Cytochrome P450 family 26 subfamily C member 1","Uniprot":["Q6V0L0"],"Chromosome":"10","Position":"93060798-93069540","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant","Ectodermal dysplasia"],"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"2.3","Epididymal clear cells":"4.1","Innate lymphoid cells":"4.7","Microglia":"12.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"2.3","Glial cells":"12.7","Innate lymphoid cells":"4.7","Reproductive supporting cells":"4.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"14.8"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA013547":null,"HPA013970":null,"HPA015066":null,"HPA074424":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"CYP2J2","Gene synonym":[],"Ensembl":"ENSG00000134716","Gene description":"Cytochrome P450 family 2 subfamily J member 2","Uniprot":["P51589"],"Chromosome":"1","Position":"59893308-59926773","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Isomerase","Monooxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"heart muscle":"83.9","intestine":"78.5","liver":"136.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"146.0","Cardiomyocytes":"306.1","Cytotrophoblasts":"134.8","Enterocytes":"149.6","Esophageal apical cells":"161.4","Hepatocytes":"69.0","Migrating cytotrophoblasts":"117.6","Myonuclei":"95.6","Oligodendrocytes":"80.2","Respiratory secretory cells":"96.6","Syncytiotrophoblasts":"311.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"161.4","Enterocytes":"149.6","Glial cells":"146.0","Myocytes":"306.1","Trophoblast cells":"311.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"77.1","Bergmann glia":"181.5","oligodendrocyte":"127.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"112.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"2.9","naive CD8 T-cell":"2.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"13.3"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"1095077.4","Hepatocytes":"3633804.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"4381430.9"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.16e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.44e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.77e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"}},{"Gene":"CYP2R1","Gene synonym":[],"Ensembl":"ENSG00000186104","Gene description":"Cytochrome P450 family 2 subfamily R member 1","Uniprot":["Q6VVX0"],"Chromosome":"11","Position":"14877440-14892231","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"97.2","Early spermatids":"216.7","Late primary spermatocytes":"105.8","Late spermatids":"146.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"216.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate basal glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"70151.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3314","Protein tissue specific Intensity":{"salivary gland":"331368.6"},"Antibody":["HPA042949"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 49: Non-specific - Transcription","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042949":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"}},{"Gene":"CYP3A43","Gene synonym":[],"Ensembl":"ENSG00000021461","Gene description":"Cytochrome P450 family 3 subfamily A member 43","Uniprot":["Q9HB55"],"Chromosome":"7","Position":"99828013-99866093","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"liver":"38.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Hepatocytes":"66.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Hepatocytes":"66.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"13","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"3.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA066463":null,"HPA072245":null,"HPA075539":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DACH1","Gene synonym":["DACH"],"Ensembl":"ENSG00000276644","Gene description":"Dachshund family transcription factor 1","Uniprot":["Q9UI36"],"Chromosome":"13","Position":"71437966-71867204","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"19.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"849.9","Distal convoluted tubule cells":"1034.1","Gonadotrophs":"783.7","M\u00fcller glia":"1078.8","Neutrophil progenitors":"1979.1","Neutrophils":"955.5","Paneth cells":"858.6","Podocytes":"5507.1","Renal connecting tubule cells":"750.7","Retinal horizontal cells":"753.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1979.1","Renal nephron cells":"5507.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"827.9","medium spiny neuron":"810.4","pericyte":"1190.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Rectum Adenocarcinoma (TCGA)":"15.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"basophil":"6.0","eosinophil":"11.3","NK-cell":"5.7","plasmacytoid DC":"9.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"29","RNA blood lineage specific nTPM":{"dendritic cells":"9.3","granulocytes":"11.3","NK-cells":"5.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"10.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Adrenal gland - Adrenal cortex cells","Liver - Hepatic stellate cells","Pituitary gland - Thyrotropes","Skin - Outer root sheath cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"basal ganglia":"38.8"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"6","RNA pig brain regional specific nTPM":{"basal ganglia":"45.2"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"1205802.0","Glomeruli":"562980.5","Neutrophils":"363390.8","Proximal tubules":"760659.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"13863","Protein tissue specific Intensity":{"fallopian tube":"1154272.2","lung":"1310735.1","lymphoid tissue":"1458611.5","ovary":"1621565.6"},"Antibody":["HPA012672","HPA012938","HPA073222"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 57: Podocytes - Glomerular filtration","Interactions":12,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA012672":null,"HPA012938":null,"HPA073222":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.89e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.01e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.13e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"}},{"Gene":"DALRD3","Gene synonym":["FLJ10496"],"Ensembl":"ENSG00000178149","Gene description":"DALR anticodon binding domain containing 3","Uniprot":["Q5D0E6"],"Chromosome":"3","Position":"49015488-49022293","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"149.3","Enterocytes":"172.2","Epicardial cells":"193.3","Fallopian tube ciliated cells":"166.7","Late primary spermatocytes":"243.0","Late spermatids":"452.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"452.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1916","Protein cell type specific Intensity":{"Fallopian tube cells":"120436.0","Granulosa cells":"92004.9","Oocytes":"362392.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036862"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA036862":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.06e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"DAW1","Gene synonym":["DNAAF18","FLJ25955","ODA16","WDR69"],"Ensembl":"ENSG00000123977","Gene description":"Dynein assembly factor with WD repeats 1","Uniprot":["Q8N136"],"Chromosome":"2","Position":"227871054-227924344","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"55.4","fallopian tube":"30.8","testis":"48.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"145.8","Early spermatids":"105.7","Ependymal cells":"309.4","Epididymal efferent duct ciliated cells":"135.1","Fallopian tube ciliated cells":"183.6","Late primary spermatocytes":"388.1","Late spermatids":"331.7","Respiratory ciliated cells":"225.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"309.4","Spermatogenic cell types":"388.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"138.1","ependymal cell":"340.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"2.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"10.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA046118":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DAZAP1","Gene synonym":["MGC19907"],"Ensembl":"ENSG00000071626","Gene description":"DAZ associated protein 1","Uniprot":["Q96EP5"],"Chromosome":"19","Position":"1407569-1435687","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"83000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Midbody","Cytosol"],"Antibody RRID":{"HPA004201":null,"HPA004631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"}},{"Gene":"DBF4","Gene synonym":["ASK","chif","DBF4A","ZDBF1"],"Ensembl":"ENSG00000006634","Gene description":"DBF4 zinc finger","Uniprot":["Q9UBU7"],"Chromosome":"7","Position":"87876216-87909553","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","DNA replication"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"testis":"14.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"314.8","Late primary spermatocytes":"1165.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1165.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":15,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA042923":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.43e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"}},{"Gene":"DBI","Gene synonym":["ACBD1","ACBP"],"Ensembl":"ENSG00000155368","Gene description":"Diazepam binding inhibitor, acyl-CoA binding protein","Uniprot":["P07108"],"Chromosome":"2","Position":"119366924-119372550","Protein class":["Cancer-related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"1417.2","Esophageal apical cells":"4467.2","Esophageal basal cells":"1821.2","Esophageal suprabasal cells":"4734.8","Hepatocytes":"2459.3","Suprabasal keratinocytes":"1642.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"4467.2","Suprabasal cells":"4734.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"151.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1952.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051428":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.00e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":31,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA024160":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.25e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA068351":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"DCAF5","Gene synonym":["BCRG2","BCRP2","D14S1461E","KIAA1824","WDR22"],"Ensembl":"ENSG00000139990","Gene description":"DDB1 and CUL4 associated factor 5","Uniprot":["Q96JK2"],"Chromosome":"14","Position":"69050881-69153150","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":37,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA041575":null,"HPA048098":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA074904":null,"HPA075774":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.80e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"}},{"Gene":"DCAF7","Gene synonym":["HAN11","SWAN-1","WDR68"],"Ensembl":"ENSG00000136485","Gene description":"DDB1 and CUL4 associated factor 7","Uniprot":["P61962"],"Chromosome":"17","Position":"63550222-63594286","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"46.3","Bergmann glia":"56.1","Brain excitatory neurons":"59.2","Brain inhibitory neurons":"57.7","Choroid plexus epithelial cells":"79.7","Distal convoluted tubule cells":"78.9","Loop of henle epithelial cells":"72.9","Microglia":"91.9","Oligodendrocyte progenitor cells":"61.0","Oligodendrocytes":"66.1","Other brain neurons":"52.5","Papillary tip epithelial cells":"66.6","Podocytes":"69.2","Proximal tubule cells":"89.3","Renal collecting duct intercalated cells":"82.6","Renal collecting duct principal cells":"75.6","Renal connecting tubule cells":"76.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"79.7","Ductal cells":"82.6","Glial cells":"91.9","Neuronal cells":"59.2","Renal nephron cells":"89.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":186,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA022948":null,"HPA022962":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.45e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.18e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"}},{"Gene":"DCC","Gene synonym":["IGDCC1","NTN1R1"],"Ensembl":"ENSG00000187323","Gene description":"DCC netrin 1 receptor","Uniprot":["P43146"],"Chromosome":"18","Position":"52340197-53535903","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Apoptosis"],"Molecular function":["Developmental protein","Receptor"],"Disease involvement":["Cancer-related genes","Disease variant","Intellectual disability","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"3.0","testis":"7.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"744.0","Brain inhibitory neurons":"1141.3","Corticotrophs":"2012.7","Early spermatids":"414.9","Late spermatids":"291.7","Oligodendrocyte progenitor cells":"1894.5","Other brain neurons":"646.5","Plasma cells":"382.2","Retinal amacrine cells":"543.0","Thyrotrophs":"568.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"1894.5","Neuronal cells":"1141.3","Pituitary endocrine cells":"2012.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"3187.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.1","Lung Squamous Cell Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bone cancer":"6.9","Myeloma":"23.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":39,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Centriolar satellite","Centrosome","Basal body"],"Antibody RRID":{"HPA055376":null,"HPA069552":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DCDC1","Gene synonym":["DCDC5","FLJ46154"],"Ensembl":"ENSG00000170959","Gene description":"Doublecortin domain containing 1","Uniprot":["M0R2J8"],"Chromosome":"11","Position":"30830369-31369810","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"2.6","fallopian tube":"2.7","liver":"2.6","retina":"2.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"751.7","Endometrial ciliated cells":"582.3","Ependymal cells":"1942.2","Epididymal efferent duct ciliated cells":"377.7","Fallopian tube ciliated cells":"549.1","Respiratory ciliated cells":"1301.0","Retinal ganglion cells":"861.4","Somatotrophs":"293.0","Thyrotrophs":"297.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"1942.2","Neuronal cells":"861.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"630.8","ependymal cell":"2099.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DCDC2","Gene synonym":["DCDC2A","DFNB66","KIAA1154","NPHP19","RU2"],"Ensembl":"ENSG00000146038","Gene description":"Doublecortin domain containing 2","Uniprot":["Q9UHG0"],"Chromosome":"6","Position":"24171755-24358059","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Neurogenesis"],"Molecular function":null,"Disease involvement":["Ciliopathy","Deafness","Disease variant","Nephronophthisis","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"19.5","kidney":"20.4","pancreas":"24.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"391.8","Distal convoluted tubule cells":"1047.2","Endometrial ciliated cells":"820.7","Endometrial glandular cells":"606.1","Endometrial luminal cells":"365.8","Ependymal cells":"369.9","Epididymal efferent duct absorptive cells":"796.2","Epididymal efferent duct ciliated cells":"781.1","Loop of henle epithelial cells":"373.0","Pancreatic duct cells":"574.2","Proximal tubule cells":"415.6","Renal collecting duct principal cells":"385.0","Renal connecting tubule cells":"1441.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"820.7","Ductal cells":"1441.3","Glandular cells":"606.1","Renal nephron cells":"1047.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"384.7","ependymal cell":"400.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"36.9"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"33.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"45.3","ovarian cancer":"38.7"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":26,"Subcellular main location":["Microtubules","Cytosol"],"Subcellular additional location":["Mitotic spindle","Centriolar satellite","Acrosome","Equatorial segment","Principal piece"],"Antibody RRID":{"HPA031582":null,"HPA031583":null,"HPA031584":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"}},{"Gene":"DCDC2B","Gene synonym":[],"Ensembl":"ENSG00000222046","Gene description":"Doublecortin domain containing 2B","Uniprot":["A2VCK2"],"Chromosome":"1","Position":"32209089-32216192","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"fallopian tube":"26.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"40.8","Epididymal efferent duct ciliated cells":"85.2","Fallopian tube ciliated cells":"148.5","Respiratory ciliated cells":"152.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"152.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"1.0","Uterine Corpus Endometrial Carcinoma (TCGA)":"3.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"30188","Protein cell type specific Intensity":{"Fallopian tube cells":"3018771.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"68790","Protein tissue specific Intensity":{"fallopian tube":"6878966.6"},"Antibody":["HPA045832"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045832":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"}},{"Gene":"DCHS1","Gene synonym":["CDH25","CDHR6","FIB1","FLJ11790","KIAA1773","PCDH16"],"Ensembl":"ENSG00000166341","Gene description":"Dachsous cadherin-related 1","Uniprot":["Q96JQ0"],"Chromosome":"11","Position":"6621330-6655809","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"15.7","Bergmann glia":"32.0","Decidual stromal cells":"15.8","Endometrial stromal cells":"19.3","Fibroblasts":"14.8","Granulosa cells":"12.2","Lymphatic endothelial cells":"25.4","Melanocytes":"15.1","Oligodendrocyte progenitor cells":"14.6","Ovarian stromal cells":"11.0","Pituicytes\/FSCs":"14.8","Smooth muscle cells":"15.2","Vascular endothelial cells":"30.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Endothelial cells":"30.8","Glial cells":"32.0","Stromal cells":"19.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"12.8","Neuroblastoma":"28.7"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA017970":null,"HPA050246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.08e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.05e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - 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Adrenal medulla cells","Kidney - Fibroblasts","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA064159"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA064159":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DCLK3","Gene synonym":["DCAMKL3","DCDC3C","KIAA1765"],"Ensembl":"ENSG00000163673","Gene description":"Doublecortin like kinase 3","Uniprot":["Q9C098"],"Chromosome":"3","Position":"36712421-36764553","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.8","testis":"2.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"21.3","Brain inhibitory neurons":"16.3","Cone photoreceptor cells":"10.4","Corticotrophs":"24.6","Early spermatids":"31.9","Lactotrophs":"14.6","Late primary spermatocytes":"60.6","Retinal amacrine cells":"20.9","Somatotrophs":"23.1","Thyrotrophs":"47.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"21.3","Neuronal cells":"20.9","Pituitary endocrine cells":"47.9","Spermatogenic cell types":"60.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"45.7","medium spiny neuron":"38.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"1.4"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA040685":null,"HPA053234":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.05e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.78e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"}},{"Gene":"DCUN1D1","Gene synonym":["DCUN1L1","RP42","SCCRO","SCRO","Tes3"],"Ensembl":"ENSG00000043093","Gene description":"Defective in cullin neddylation 1 domain containing 1","Uniprot":["Q96GG9"],"Chromosome":"3","Position":"182938074-182985953","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"231.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Late spermatids":"24837.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"92","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"24837.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"280000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":35,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035911":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.70e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.57e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.29e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"}},{"Gene":"DDA1","Gene synonym":["C19orf58","MGC2594","PCIA1"],"Ensembl":"ENSG00000130311","Gene description":"DET1 and DDB1 associated 1","Uniprot":["Q9BW61"],"Chromosome":"19","Position":"17309518-17323298","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"151.9","Early spermatids":"473.3","Esophageal apical cells":"245.7","Extravillous trophoblasts":"196.5","Late primary spermatocytes":"293.2","Late spermatids":"158.8","Migrating cytotrophoblasts":"202.1","Syncytiotrophoblasts":"306.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"245.7","Spermatogenic cell types":"473.3","Trophoblast cells":"306.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":71,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA042134":null,"HPA055272":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"DDC","Gene synonym":["AADC"],"Ensembl":"ENSG00000132437","Gene description":"Dopa decarboxylase","Uniprot":["P20711"],"Chromosome":"7","Position":"50458436-50565405","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Catecholamine biosynthesis"],"Molecular function":["Decarboxylase","Lyase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"156.1","kidney":"294.0","retina":"162.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"63.8","Enterocytes":"32.7","Neuroendocrine cells":"32.9","Proximal tubule cells":"16.3","Retinal bipolar cells":"10.7","Retinal ganglion cells":"11.6","Retinal horizontal cells":"14.0","Rod photoreceptor cells":"108.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"63.8","Enterocytes":"32.7","Enteroendocrine cells":"32.9","Neuronal cells":"108.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"splatter":"1.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"9","RNA brain regional specific nTPM":{"midbrain":"179.5","pons":"59.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"108.9"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enterocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skin - Sebaceous gland cells","Testis - Early spermatids","Thyroid gland - Parafollicular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"5","RNA pig brain regional specific nTPM":{"midbrain":"97.7","pons":"40.1"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"247774790.0","Proximal tubules":"563507020.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"38239545.2","kidney":"25826158.2","lymphoid tissue":"25297803.5","ovary":"10522444.5"},"Antibody":["HPA017742"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Actin filaments","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":["Actin filaments"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA017742":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.83e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-4"}},{"Gene":"DDHD1","Gene synonym":["iPLA1alpha","KIAA1705","PA-PLA1","PAPLA1","SPG28"],"Ensembl":"ENSG00000100523","Gene description":"DDHD domain containing 1","Uniprot":["Q8NEL9"],"Chromosome":"14","Position":"53036745-53153323","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism","Phospholipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"28.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"358.4","Gonadotrophs":"238.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"358.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"11265758.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"3255998.2"},"Antibody":["HPA049870"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049870":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.03e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"}},{"Gene":"DDI1","Gene synonym":["FLJ36017"],"Ensembl":"ENSG00000170967","Gene description":"DNA damage inducible 1 homolog 1","Uniprot":["Q8WTU0"],"Chromosome":"11","Position":"104036640-104039196","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Aspartyl protease","Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"241","RNA tissue specific nTPM":{"testis":"24.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"393.2","Late primary spermatocytes":"259.4","Late spermatids":"1504.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"330","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1504.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA079511"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA079511":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DDIT4L","Gene synonym":["REDD2","Rtp801L"],"Ensembl":"ENSG00000145358","Gene description":"DNA damage inducible transcript 4 like","Uniprot":["Q96D03"],"Chromosome":"4","Position":"100185870-100190782","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"skeletal muscle":"303.4","tongue":"99.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"76.7","Endometrial secretory cells":"19.1","Extravillous trophoblasts":"25.9","Hofbauer cells":"27.4","Myonuclei":"53.6","Salivary basal cells":"20.4","Salivary duct cells":"28.6","Salivary ionocytes":"18.1","Thymic myoid cells":"96.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Goblet cells":"76.7","Myocytes":"53.6","Stromal cells":"96.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"15.1","medium spiny neuron":"13.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"32.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"8.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":171,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Actin filaments"],"Antibody RRID":{"HPA050903":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":47,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB037229":null,"CAB037284":null,"HPA046380":null,"HPA066668":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.26e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"}},{"Gene":"DDX20","Gene synonym":["DP103","GEMIN3"],"Ensembl":"ENSG00000064703","Gene description":"DEAD-box helicase 20","Uniprot":["Q9UHI6"],"Chromosome":"1","Position":"111754832-111775602","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["DNA-binding","Helicase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"38.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"815.0","Late primary spermatocytes":"480.9","Late spermatids":"1199.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1199.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":79,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"CAB015427":null,"HPA005516":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"}},{"Gene":"DDX25","Gene synonym":["GRTH"],"Ensembl":"ENSG00000109832","Gene description":"DEAD-box helicase 25","Uniprot":["Q9UHL0"],"Chromosome":"11","Position":"125903348-125943702","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","mRNA transport","Spermatogenesis","Translation regulation","Transport"],"Molecular function":["Developmental protein","Helicase","Hydrolase","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"21.8","retina":"20.2","testis":"85.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"297.3","Epicardial cells":"352.5","Late primary spermatocytes":"626.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"352.5","Spermatogenic cell types":"626.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"8.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"5.9"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020137":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.01e-6"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"}},{"Gene":"DDX27","Gene synonym":["dJ686N3.1","DRS1"],"Ensembl":"ENSG00000124228","Gene description":"DEAD-box helicase 27","Uniprot":[],"Chromosome":"20","Position":"49219347-49244077","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"201.3","Late spermatids":"187.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":36,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA047087":null,"HPA053455":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.92e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.42e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"}},{"Gene":"DDX39A","Gene synonym":["BAT1L","DDX39","DDXL","URH49"],"Ensembl":"ENSG00000123136","Gene description":"DExD-box helicase 39A","Uniprot":["O00148"],"Chromosome":"19","Position":"14408798-14419383","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["Helicase","Hydrolase","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"155.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"226.7","Early spermatids":"288.1","Esophageal basal cells":"179.1","Late primary spermatocytes":"529.6","Late spermatids":"380.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"529.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"270000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":43,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA055334":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.68e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"}},{"Gene":"DDX4","Gene synonym":["VASA"],"Ensembl":"ENSG00000152670","Gene description":"DEAD-box helicase 4","Uniprot":["Q9NQI0"],"Chromosome":"5","Position":"55738017-55817157","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","RNA-mediated gene silencing","Spermatogenesis"],"Molecular function":["Developmental protein","Helicase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"113","RNA tissue specific nTPM":{"testis":"139.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"129.4","Early primary spermatocytes":"289.6","Early spermatids":"700.2","Late primary spermatocytes":"676.5","Late spermatids":"240.8","Oocytes":"138.2","Respiratory ionocytes":"109.2","Undifferentiated spermatogonia":"168.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"700.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"14.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"40","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"7.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland ductal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"981477","Protein cell type specific Intensity":{"Oocytes":"98147674.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB026170","HPA037763","HPA037764"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB026170":null,"HPA037763":null,"HPA037764":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DDX52","Gene synonym":["ROK1"],"Ensembl":"ENSG00000278053","Gene description":"DExD-box helicase 52","Uniprot":["Q9Y2R4"],"Chromosome":"17","Position":"37609739-37643446","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Helicase","Hydrolase","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"195.2","Endometrial glandular cells":"159.8","Late spermatids":"91.6","Renal collecting duct intercalated cells":"103.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"159.8","Spermatogenic cell types":"195.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"DDX53","Gene synonym":["CAGE","CT26"],"Ensembl":"ENSG00000184735","Gene description":"DEAD-box helicase 53","Uniprot":["Q86TM3"],"Chromosome":"X","Position":"22999960-23003589","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Helicase","Hydrolase","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"51","RNA tissue specific nTPM":{"testis":"5.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"60.5","Late primary spermatocytes":"43.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"60.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"1.4","prostate cancer":"1.0"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA003186":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":8,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA064486":null,"HPA065101":null,"HPA073628":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":20,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038975":null,"HPA038976":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA079460":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DEFB124","Gene synonym":["DEFB-24"],"Ensembl":"ENSG00000180383","Gene description":"Defensin beta 124","Uniprot":["Q8NES8"],"Chromosome":"20","Position":"31465471-31476757","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Antibiotic","Antimicrobial","Defensin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"12.4","Endometrial stromal cells":"10.6","Epicardial cells":"4.5","Epididymal principal cells":"5.7","Fallopian tube ciliated cells":"16.8","Pericytes":"15.9","Respiratory ciliated cells":"8.0","Vascular smooth muscle cells":"3.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"4.5","Ciliated cells":"16.8","Mural cells":"15.9","Reproductive supporting cells":"5.7","Stromal cells":"12.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"2.6","vascular associated smooth muscle cell":"1.8"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"9.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":13,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020481":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"}},{"Gene":"DENND2D","Gene synonym":["FLJ22457","RP5-1180E21.2"],"Ensembl":"ENSG00000162777","Gene description":"DENN domain containing 2D","Uniprot":["Q9H6A0"],"Chromosome":"1","Position":"111185969-111204535","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"87.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"219.8","Esophageal suprabasal cells":"99.3","Hofbauer cells":"108.2","Late primary spermatocytes":"76.9","Late spermatids":"88.7","NK-cells":"111.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"219.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"leukocyte":"96.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"gdT-cell":"237.2","MAIT T-cell":"204.6","memory CD4 T-cell":"172.4","memory CD8 T-cell":"243.8","naive CD4 T-cell":"266.2","naive CD8 T-cell":"257.5","NK-cell":"279.1","T-reg":"79.7"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"NK-cells":"279.1","T-cells":"266.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 27: T-cells - Unknown function","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":3,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043630":null,"HPA048642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.82e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"}},{"Gene":"DENND5B","Gene synonym":["MGC24039"],"Ensembl":"ENSG00000170456","Gene description":"DENN domain containing 5B","Uniprot":["Q6ZUT9"],"Chromosome":"12","Position":"31382226-31591136","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Lactotrophs":"482.6","Myonuclei":"456.2","Thyrotrophs":"468.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"1.4","naive B-cell":"1.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"52.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA038865":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":15,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA038255":null,"HPA072558":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"}},{"Gene":"DEPDC4","Gene synonym":["DEP.4","FLJ33505"],"Ensembl":"ENSG00000166153","Gene description":"DEP domain containing 4","Uniprot":["Q8N2C3"],"Chromosome":"12","Position":"100203669-100267079","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"2.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"38.4","Epicardial cells":"40.9","Late spermatids":"31.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"40.9","Myocytes":"38.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA039323":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DEPDC7","Gene synonym":[],"Ensembl":"ENSG00000121690","Gene description":"DEP domain containing 7","Uniprot":["Q96QD5"],"Chromosome":"11","Position":"33015876-33033582","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"intestine":"27.3","kidney":"18.2","liver":"69.2","testis":"26.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"38.6","Early spermatids":"179.7","Enterocytes":"45.1","Extravillous trophoblasts":"77.2","Hepatocytes":"41.2","Late primary spermatocytes":"150.8","Oocytes":"36.8","Schwann cells":"35.0","Tuft cells":"57.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Secretory gland support":"57.6","Spermatogenic cell types":"179.7","Trophoblast cells":"77.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"8.1","committed oligodendrocyte precursor":"9.2","oligodendrocyte":"14.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"6.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA015800":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.35e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"}},{"Gene":"DERL2","Gene synonym":["CGI-101","derlin-2","F-LAN-1","F-LANa","FLANa"],"Ensembl":"ENSG00000072849","Gene description":"Derlin 2","Uniprot":["Q9GZP9"],"Chromosome":"17","Position":"5471254-5486811","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Host-virus interaction","Unfolded protein response"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"217.2","Late primary spermatocytes":"305.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"305.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"402921.6"},"Antibody":["CAB037287","HPA048957","HPA056551"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":62,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB037287":null,"HPA048957":null,"HPA056551":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.29e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"}},{"Gene":"DERL3","Gene synonym":["C22orf14","derlin-3","FLJ43842","IZP6","MGC71803"],"Ensembl":"ENSG00000099958","Gene description":"Derlin 3","Uniprot":["Q96Q80"],"Chromosome":"22","Position":"23834503-23839128","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"41.2","pancreas":"41.6","salivary gland":"34.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Plasma cells":"800.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Plasma cells":"800.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"14.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"14","RNA blood cell specific nTPM":{"plasmacytoid DC":"187.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"14","RNA blood lineage specific nTPM":{"dendritic cells":"187.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Myeloma":"39.7"},"RNA tissue cell type enrichment":["Adipose visceral - Plasma cells","Breast - Plasma cells","Lung - Plasma cells","Minor Salivary Gland - Plasma cells","Spleen - Plasma cells","Stomach - Plasma cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"2059401.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"202894.7","lymphoid tissue":"282790.8"},"Antibody":["CAB037234","HPA049306"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":14,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB037234":null,"HPA049306":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.85e-6"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"}},{"Gene":"DESI1","Gene synonym":["D15Wsu75e","DESI-1","FAM152B","POST","PPPDE2"],"Ensembl":"ENSG00000100418","Gene description":"Desumoylating isopeptidase 1","Uniprot":["Q6ICB0"],"Chromosome":"22","Position":"41598028-41621043","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"935.5","Esophageal apical cells":"584.8","Esophageal suprabasal cells":"225.6","Late primary spermatocytes":"444.3","Late spermatids":"809.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"584.8","Spermatogenic cell types":"935.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"11859946.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"7913419.6"},"Antibody":["HPA053415"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytokinetic bridge","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Cytokinetic bridge"],"Antibody RRID":{"HPA053415":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"}},{"Gene":"DESI2","Gene synonym":["C1orf121","CGI-146","DESI-2","FAM152A","FLJ21998","PNAS-4","PPPDE1"],"Ensembl":"ENSG00000121644","Gene description":"Desumoylating isopeptidase 2","Uniprot":["Q9BSY9"],"Chromosome":"1","Position":"244653103-244709033","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"226.6","Late primary spermatocytes":"294.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"294.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"5699425.3","skeletal muscle":"4188785.1"},"Antibody":["HPA049950"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049950":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"}},{"Gene":"DEUP1","Gene synonym":["CCDC67","FLJ25393"],"Ensembl":"ENSG00000165325","Gene description":"Deuterosome assembly protein 1","Uniprot":["Q05D60"],"Chromosome":"11","Position":"93329971-93438487","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"fallopian tube":"4.5","testis":"15.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"80.4","Early spermatids":"234.6","Fallopian tube ciliated cells":"63.6","Late primary spermatocytes":"337.8","Late spermatids":"244.1","Respiratory ciliated cells":"61.9","Respiratory deuterosomal cells":"115.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"115.1","Myocytes":"80.4","Spermatogenic cell types":"337.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"30.5","ependymal cell":"48.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"1.2"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2864","Protein cell type specific Intensity":{"Fallopian tube cells":"286382.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":40,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DGAT1","Gene synonym":["ARGP1","DGAT"],"Ensembl":"ENSG00000185000","Gene description":"Diacylglycerol O-acyltransferase 1","Uniprot":["O75907"],"Chromosome":"8","Position":"144314584-144326910","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Lipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"41.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"20.4","Astrocytes":"19.0","Bergmann glia":"14.3","Brain excitatory neurons":"15.2","Brain inhibitory neurons":"14.9","Choroid plexus epithelial cells":"14.0","Enterocytes":"21.0","Oligodendrocyte progenitor cells":"23.7","Oligodendrocytes":"13.2","Other brain neurons":"11.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"20.4","Enterocytes":"21.0","Glial cells":"23.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"1305326.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2363676.6"},"Antibody":["CAB032853"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Nucleoli rim","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":6,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Nucleoli","Nucleoli rim"],"Antibody RRID":{"CAB032853":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"}},{"Gene":"DGAT2","Gene synonym":[],"Ensembl":"ENSG00000062282","Gene description":"Diacylglycerol O-acyltransferase 2","Uniprot":["Q96PD7"],"Chromosome":"11","Position":"75759512-75801535","Protein class":["Enzymes","FDA approved drug targets","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Glycerol metabolism","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"adipose tissue":"447.0","breast":"135.2","liver":"309.8","skin 1":"147.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"313.4","Early primary spermatocytes":"66.6","Early spermatids":"355.5","Esophageal apical cells":"187.1","Hepatocytes":"144.6","Late primary spermatocytes":"134.4","Late spermatids":"110.7","Neutrophils":"399.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Adipocytes":"313.4","Apical squamous epithelial cells":"187.1","Hepatocytes":"144.6","Neutrophils":"399.2","Spermatogenic cell types":"355.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"16.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"96.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"eosinophil":"138.1","neutrophil":"350.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"16","RNA blood lineage specific nTPM":{"granulocytes":"350.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Liver - Hepatocytes","Lung - Neutrophils_2","Skin - Keratinocyte (granular)","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"basal ganglia":"30.0"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"397261.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3365","Protein tissue specific Intensity":{"liver":"336540.5"},"Antibody":["HPA013351"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":null,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA013351":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.18e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"}},{"Gene":"DGKA","Gene synonym":["DAGK","DAGK1","DGK-alpha"],"Ensembl":"ENSG00000065357","Gene description":"Diacylglycerol kinase alpha","Uniprot":["P23743"],"Chromosome":"12","Position":"55927319-55954027","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"184.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"96.8","Esophageal apical cells":"200.1","Ocular epithelial cells":"87.6","Prostatic hillock cells":"84.8","Thymocytes":"75.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"200.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"68.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"T-cells":"87.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 6: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Mitochondria"],"Antibody RRID":{"HPA041645":null,"HPA045462":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.00e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"}},{"Gene":"DGKE","Gene synonym":["DAGK6","DGK"],"Ensembl":"ENSG00000153933","Gene description":"Diacylglycerol kinase epsilon","Uniprot":["P52429"],"Chromosome":"17","Position":"56834107-56869567","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Disease variant","Hemolytic uremic syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"31.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"97.9","Cone photoreceptor cells":"159.4","Lactotrophs":"118.8","Retinal bipolar cells":"243.3","Rod photoreceptor cells":"212.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"243.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Lactotropes","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"9283913.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"40648580.6"},"Antibody":["HPA017167"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":3,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017167":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.60e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"}},{"Gene":"DGKI","Gene synonym":["DGK-IOTA"],"Ensembl":"ENSG00000157680","Gene description":"Diacylglycerol kinase iota","Uniprot":["O75912"],"Chromosome":"7","Position":"137381037-137847092","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"11.5","retina":"6.3","thyroid gland":"14.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"615.7","Brain inhibitory neurons":"859.8","Choroid plexus epithelial cells":"1778.5","Lactotrophs":"505.5","Respiratory ionocytes":"2131.1","Retinal amacrine cells":"584.2","Retinal bipolar cells":"933.2","Retinal horizontal cells":"1067.8","Salivary ionocytes":"4573.5","Thyrotrophs":"726.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1778.5","Ionocytes":"4573.5","Neuronal cells":"1067.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"9.8","Thyroid Carcinoma (TCGA)":"2.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"9.5"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland ductal cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"4080648.6","Neurons":"4270637.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"79849","Protein tissue specific Intensity":{"cerebral cortex":"7984895.9"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.58e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DHFR","Gene synonym":[],"Ensembl":"ENSG00000228716","Gene description":"Dihydrofolate reductase","Uniprot":["P00374"],"Chromosome":"5","Position":"80626226-80654983","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Essential proteins","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Methotrexate resistance","One-carbon metabolism"],"Molecular function":["Oxidoreductase","RNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"446.4","Loop of henle epithelial cells":"307.4","Papillary tip epithelial cells":"244.2","Podocytes":"325.7","Proximal tubule cells":"882.7","Renal collecting duct intercalated cells":"455.3","Renal collecting duct principal cells":"228.4","Renal connecting tubule cells":"429.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ductal cells":"455.3","Renal nephron cells":"882.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Liver - Hepatocytes","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"3145367.5","Hepatocytes":"1978962.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"5641349.9","intestine":"5613307.5","liver":"3984922.3","skin":"4888245.9"},"Antibody":["CAB037129","HPA051465"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":49,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB037129":null,"HPA051465":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"DHRS11","Gene synonym":["MGC4172","SDR24C1"],"Ensembl":"ENSG00000278535","Gene description":"Dehydrogenase\/reductase 11","Uniprot":["Q6UWP2"],"Chromosome":"17","Position":"36591879-36600804","Protein class":["Enzymes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Lipid metabolism","Steroid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"intestine":"203.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"6.0","Brain excitatory neurons":"10.5","Brain inhibitory neurons":"13.1","Choroid plexus epithelial cells":"12.1","Colonocytes":"6.2","Distal convoluted tubule cells":"8.6","Enterocytes":"10.7","Ependymal cells":"7.1","Loop of henle epithelial cells":"6.8","Other brain neurons":"14.0","Renal collecting duct intercalated cells":"6.5","Renal connecting tubule cells":"8.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"12.1","Ductal cells":"8.4","Enterocytes":"10.7","Neuronal cells":"14.0","Renal nephron cells":"8.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary gland basal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"10228484.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"100990168.8"},"Antibody":["HPA041226","HPA048236","HPA053623"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":"Secreted to digestive system","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"51000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA041226":null,"HPA048236":null,"HPA053623":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"}},{"Gene":"DHRS7B","Gene synonym":["CGI-93","DKFZp566O084","MGC8916","SDR32C1"],"Ensembl":"ENSG00000109016","Gene description":"Dehydrogenase\/reductase 7B","Uniprot":["Q6IAN0"],"Chromosome":"17","Position":"21123364-21193265","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"207.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"14634249.3"},"Antibody":["HPA012132","HPA016873"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cell Junctions","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":29,"Subcellular main location":["Plasma membrane","Cell Junctions","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA012132":null,"HPA016873":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.96e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-4"}},{"Gene":"DHRS7C","Gene synonym":["SDR32C2"],"Ensembl":"ENSG00000184544","Gene description":"Dehydrogenase\/reductase 7C","Uniprot":["A6NNS2"],"Chromosome":"17","Position":"9771434-9791592","Protein class":["Enzymes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"64","RNA tissue specific nTPM":{"heart muscle":"102.3","skeletal muscle":"288.6","tongue":"342.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"4.2","Corticotrophs":"5.0","Early spermatids":"7.9","Late primary spermatocytes":"3.7","Late spermatids":"27.7","Myonuclei":"22.4","Thymic myoid cells":"4.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"22.4","Spermatogenic cell types":"27.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"thalamus":"1.7"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"96071","Protein cell type specific Intensity":{"Capillaries":"3528327.7","Cardiomyocytes":"12177461.0","Skeletal myofibers":"13115550.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"10783079.8"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":null,"Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DHRS9","Gene synonym":["3alpha-HSD","RDH15","RDHL","RETSDR8","SDR9C4"],"Ensembl":"ENSG00000073737","Gene description":"Dehydrogenase\/reductase 9","Uniprot":["Q9BPW9"],"Chromosome":"2","Position":"169064789-169096167","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism","Steroid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"50.2","intestine":"66.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"385.2","Conjunctival goblet cells":"116.5","Early spermatids":"158.8","Esophageal apical cells":"427.1","Foveolar cells":"161.7","Goblet cells":"136.5","Late primary spermatocytes":"112.6","Mast cells":"120.7","Microglia":"113.7","Neutrophil progenitors":"120.4","Neutrophils":"155.1","Respiratory ciliated cells":"115.8","Respiratory secretory cells":"186.2","Syncytiotrophoblasts":"577.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"427.1","Enterocytes":"385.2","Trophoblast cells":"577.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"49","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"119.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"61.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"basophil":"259.3","eosinophil":"99.5","neutrophil":"77.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"259.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"144.7","pancreatic cancer":"82.9"},"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Spleen - Neutrophils_2","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036491","HPA036667"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036491":null,"HPA036667":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.63e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"}},{"Gene":"DHX16","Gene synonym":["DBP2","DDX16","Prp2","PRPF2"],"Ensembl":"ENSG00000204560","Gene description":"DEAH-box helicase 16","Uniprot":["O60231"],"Chromosome":"6","Position":"30653119-30673006","Protein class":["Disease related genes","Enzymes","Essential proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Immunity","Innate immunity","mRNA processing","mRNA splicing"],"Molecular function":["Helicase","Hydrolase"],"Disease involvement":["Disease variant","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"78.3","Late primary spermatocytes":"131.6","Late spermatids":"57.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"131.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"7795010.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"4529186.2"},"Antibody":["HPA051455"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":40,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA051455":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.05e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.56e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"}},{"Gene":"DHX30","Gene synonym":["DDX30","FLJ11214","KIAA0890"],"Ensembl":"ENSG00000132153","Gene description":"DExH-box helicase 30","Uniprot":["Q7L2E3"],"Chromosome":"3","Position":"47802909-47850195","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":["Helicase","Hydrolase","RNA-binding"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"229.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"229.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"124586502.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034806"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"38000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":89,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA034806":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"}},{"Gene":"DHX32","Gene synonym":["DDX32","DHLP1","FLJ10694","FLJ10889"],"Ensembl":"ENSG00000089876","Gene description":"DEAH-box helicase 32 (putative)","Uniprot":["Q7L7V1"],"Chromosome":"10","Position":"125836337-125896436","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Helicase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"280.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"280.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate basal glandular cells","Spleen - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"4976645.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1519340.9","pancreas":"1253143.8"},"Antibody":["HPA048872"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048872":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"}},{"Gene":"DHX57","Gene synonym":["DDX57"],"Ensembl":"ENSG00000163214","Gene description":"DExH-box helicase 57","Uniprot":["Q6P158"],"Chromosome":"2","Position":"38797729-38875934","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Helicase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"202.5","Late spermatids":"625.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"625.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"10715709.7","Neurons":"7502922.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"2360600.2"},"Antibody":["HPA036160","HPA036161"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":52,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036160":null,"HPA036161":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.01e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"}},{"Gene":"DIAPH3","Gene synonym":["AN","AUNA1","DRF3","FLJ34705","NSDAN"],"Ensembl":"ENSG00000139734","Gene description":"Diaphanous related formin 3","Uniprot":["Q9NSV4"],"Chromosome":"13","Position":"59665583-60163928","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Deafness","Neuropathy","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"6.7","testis":"17.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"135.7","Early spermatids":"534.8","Erythrocyte progenitors":"291.6","Extravillous trophoblasts":"183.3","Late primary spermatocytes":"390.1","Megakaryocyte progenitors":"150.9","Mesothelial cells":"200.1","Migrating cytotrophoblasts":"152.9","Monocyte progenitors":"230.4","Neutrophil progenitors":"186.1","Parietal cells":"281.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"291.6","Gastric glandular cells":"281.1","Spermatogenic cell types":"534.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"105.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"27575","Protein cell type specific Intensity":{"Granulosa cells":"2568532.0","Oocytes":"2946450.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA032151"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":8,"Subcellular main location":["Plasma membrane","Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA032151":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.37e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.38e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.75e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.87e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"}},{"Gene":"DIO1","Gene synonym":["TXDI1"],"Ensembl":"ENSG00000211452","Gene description":"Iodothyronine deiodinase 1","Uniprot":["P49895"],"Chromosome":"1","Position":"53891239-53911086","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Thyroid hormones biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"42","RNA tissue specific nTPM":{"kidney":"135.2","liver":"173.3","thyroid gland":"243.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Hepatocytes":"78.1","Proximal tubule cells":"81.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Hepatocytes":"78.1","Renal nephron cells":"81.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"70.8","Thyroid Carcinoma (TCGA)":"85.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"12","RNA cell line specific nTPM":{"breast cancer":"3.8","liver cancer":"2.5","prostate cancer":"4.9","thyroid cancer":"9.2"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.51e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DIO2","Gene synonym":["SELENOY","SelY","TXDI2"],"Ensembl":"ENSG00000211448","Gene description":"Iodothyronine deiodinase 2","Uniprot":["Q92813"],"Chromosome":"14","Position":"80197526-80387757","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Thyroid hormones biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"153.7","thyroid gland":"332.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Esophageal apical cells":"2054.0","Extravillous trophoblasts":"1049.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2054.0","Trophoblast cells":"1049.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"85.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"95.8","Brain cancer":"82.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 33: Thyroid gland - Tissue development","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":4,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA048002":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"}},{"Gene":"DIS3","Gene synonym":["dis3p","EXOSC11","KIAA1008","RRP44"],"Ensembl":"ENSG00000083520","Gene description":"DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease","Uniprot":["Q9Y2L1"],"Chromosome":"13","Position":"72752169-72782096","Protein class":["Cancer-related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":["Endonuclease","Exonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"165.4","Late spermatids":"222.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"222.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"4572963.5","intestine":"8704225.1","lymphoid tissue":"6966096.1","pancreas":"4226699.3"},"Antibody":["HPA039281","HPA058762"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":46,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039281":null,"HPA058762":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"}},{"Gene":"DIS3L2","Gene synonym":["FAM6A","FLJ36974","MGC42174"],"Ensembl":"ENSG00000144535","Gene description":"DIS3 like 3'-5' exoribonuclease 2","Uniprot":["Q8IYB7"],"Chromosome":"2","Position":"231961245-232344350","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Exonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":["Disease variant","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"8646098.1"},"Antibody":["HPA035796","HPA035797"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035796":null,"HPA035797":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.35e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"}},{"Gene":"DISC1","Gene synonym":[],"Ensembl":"ENSG00000162946","Gene description":"DISC1 scaffold protein","Uniprot":["Q9NRI5"],"Chromosome":"1","Position":"231626790-232041272","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Neurogenesis","Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":["Schizophrenia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"20.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"3199.9","Microglia":"1143.7","Neutrophils":"600.1","Oligodendrocyte progenitor cells":"792.5","Rod photoreceptor cells":"866.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1143.7","Myocytes":"3199.9","Neuronal cells":"866.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1466.3","oligodendrocyte precursor cell":"865.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1730","Protein tissue specific Intensity":{"lymphoid tissue":"172955.2"},"Antibody":["HPA048911"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Intermediate filaments","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":178,"Subcellular main location":["Intermediate filaments","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA048911":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.81e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"}},{"Gene":"DISP2","Gene synonym":["C15orf36","DISPB","HsT16908","KIAA1742","LINC00594"],"Ensembl":"ENSG00000140323","Gene description":"Dispatched RND transporter family member 2","Uniprot":["A7MBM2"],"Chromosome":"15","Position":"40358219-40378621","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"17","RNA tissue specific nTPM":{"brain":"25.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"21.3","Brain excitatory neurons":"45.7","Brain inhibitory neurons":"30.8","Colonocytes":"26.8","Enteric stem cells":"13.5","Enteric transient amplifying cells":"13.8","Enterocytes":"19.8","Goblet cells":"35.6","Neuroendocrine cells":"20.9","Other brain neurons":"34.3","Paneth cells":"38.7","Retinal amacrine cells":"22.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"26.8","Goblet cells":"35.6","Neuronal cells":"45.7","Secretory gland support":"38.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"96.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"881906.9","Microglia and Neuropil":"252494.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1779","Protein tissue specific Intensity":{"cerebral cortex":"177924.2"},"Antibody":["HPA059903"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA059903":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.15e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.63e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DIXDC1","Gene synonym":["Dixin","KIAA1735"],"Ensembl":"ENSG00000150764","Gene description":"DIX domain containing 1","Uniprot":["Q155Q3"],"Chromosome":"11","Position":"111927144-112022653","Protein class":["Predicted intracellular proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Actin-binding","Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"223.2","Cone photoreceptor cells":"252.6","Ependymal cells":"245.0","Proximal tubule cells":"235.5","Respiratory ciliated cells":"295.9","Rod photoreceptor cells":"253.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"295.9","Neuronal cells":"253.0","Renal nephron cells":"235.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"eosinophil":"5.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"granulocytes":"5.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Fibroblasts_2","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"98302.8","Pancreas epithelial cells":"153796.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"543898.1","cerebral cortex":"2022896.8","fallopian tube":"1028689.6","Stomach":"736146.0"},"Antibody":["HPA039424","HPA039658","HPA061366"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039424":null,"HPA039658":null,"HPA061366":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"}},{"Gene":"DKK4","Gene synonym":[],"Ensembl":"ENSG00000104371","Gene description":"Dickkopf WNT signaling pathway inhibitor 4","Uniprot":["Q9UBT3"],"Chromosome":"8","Position":"42374063-42377229","Protein class":["Predicted secreted proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"4.6","intestine":"2.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Esophageal apical cells":"36.7","Ocular epithelial cells":"20.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"36.7","Barrier epithelial cells":"20.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"160.3"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"8.4"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"28","RNA cell line specific nTPM":{"breast cancer":"169.4"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland basal cells","Pituitary gland - Thyrotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052916"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052916":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"}},{"Gene":"DKKL1","Gene synonym":["CT34","SGY-1"],"Ensembl":"ENSG00000104901","Gene description":"Dickkopf like acrosomal protein 1","Uniprot":["Q9UK85"],"Chromosome":"19","Position":"49361783-49375116","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"299","RNA tissue specific nTPM":{"testis":"352.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"116","RNA single cell type specific nCPM":{"Early spermatids":"2507.9","Late primary spermatocytes":"1665.2","Late spermatids":"3112.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"168","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3112.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"3.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"8.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"memory B-cell":"1.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"B-cells":"1.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB025410","HPA047194"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Acrosome","Equatorial segment","Mid piece"],"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":42,"Subcellular main location":["Vesicles","Acrosome","Equatorial segment"],"Subcellular additional location":["Mid piece"],"Antibody RRID":{"CAB025410":null,"HPA047194":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"}},{"Gene":"DLEC1","Gene synonym":["CFAP81","DLC1","FAP81"],"Ensembl":"ENSG00000008226","Gene description":"DLEC1 cilia and flagella associated protein","Uniprot":["Q9Y238"],"Chromosome":"3","Position":"38039205-38124025","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"14.4","fallopian tube":"17.9","pituitary gland":"9.2","testis":"12.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"96.8","Endometrial ciliated cells":"106.7","Ependymal cells":"238.7","Epididymal efferent duct ciliated cells":"67.2","Fallopian tube ciliated cells":"137.6","Respiratory ciliated cells":"210.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"238.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"76.9","ependymal cell":"243.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019077":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"}},{"Gene":"DLG2","Gene synonym":["chapsyn-110","PPP1R58","PSD-93","PSD93"],"Ensembl":"ENSG00000150672","Gene description":"Discs large MAGUK scaffold protein 2","Uniprot":["Q15700"],"Chromosome":"11","Position":"83455012-85628335","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"46.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"3711.7","Brain inhibitory neurons":"3586.7","Cone photoreceptor cells":"6564.3","Oligodendrocyte progenitor cells":"2976.1","Oligodendrocytes":"4673.4","Other brain neurons":"2372.4","Pituicytes\/FSCs":"4337.8","Podocytes":"2874.7","Retinal bipolar cells":"12775.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"4673.4","Neuronal cells":"12775.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"10.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Bone cancer":"45.9"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":18,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB072341":null,"HPA021307":null,"HPA023896":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DLG4","Gene synonym":["PSD-95","PSD95","SAP-90","SAP90"],"Ensembl":"ENSG00000132535","Gene description":"Discs large MAGUK scaffold protein 4","Uniprot":["P78352"],"Chromosome":"17","Position":"7187187-7219841","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"211.2","retina":"200.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"48.6","Cone photoreceptor cells":"209.1","Retinal bipolar cells":"64.8","Rod photoreceptor cells":"141.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"209.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"28.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1336960","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"104196307.5","Microglia and Neuropil":"173269346.2","Neurons":"123622273.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"197582381.6"},"Antibody":["CAB001999","CAB002000","HPA010122","HPA071006"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Plasma membrane","Primary cilium","Primary cilium tip","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":78,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body"],"Subcellular additional location":["Plasma membrane","Primary cilium","Primary cilium tip","Cytosol"],"Antibody RRID":{"CAB001999":null,"CAB002000":null,"HPA010122":null,"HPA071006":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"}},{"Gene":"DLGAP2","Gene synonym":["C8orf68","DAP-2","ERICH1-AS1"],"Ensembl":"ENSG00000198010","Gene description":"DLG associated protein 2","Uniprot":["Q9P1A6"],"Chromosome":"8","Position":"737628-1708476","Protein class":["Nuclear receptors","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"6.1","testis":"11.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Bergmann glia":"277.3","Brain excitatory neurons":"864.3","Brain inhibitory neurons":"871.2","Other brain neurons":"389.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"277.3","Neuronal cells":"871.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"1.5"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Kidney - Proximal tubular cells","Pituitary gland - Somatotropes","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"7342488.2","Microglia and Neuropil":"24725234.8","Neurons":"6853212.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"188785","Protein tissue specific Intensity":{"cerebral cortex":"18878508.2"},"Antibody":["HPA030320"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030320":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DLGAP5","Gene synonym":["DLG1","DLG7","HURP","KIAA0008"],"Ensembl":"ENSG00000126787","Gene description":"DLG associated protein 5","Uniprot":["Q15398"],"Chromosome":"14","Position":"55148112-55191608","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"28.0","lymphoid tissue":"39.1","testis":"16.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"39.3","Early primary spermatocytes":"58.4","Erythrocyte progenitors":"233.0","Late primary spermatocytes":"71.9","Megakaryocyte progenitors":"81.2","Monocyte progenitors":"161.5","Neutrophil progenitors":"63.2","Oocytes":"280.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"233.0","Mononuclear phagocytes":"161.5","Oocytes":"280.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"5.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"5.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"13245803.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1532","Protein tissue specific Intensity":{"bone marrow":"153184.0"},"Antibody":["HPA005546","HPA071028"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitotic spindle","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":22,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Mitotic spindle"],"Antibody RRID":{"HPA005546":null,"HPA071028":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.43e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.92e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.02e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.64e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.30e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.28e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.12e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"DMAC2L","Gene synonym":["ATP5S","ATPW","HSU79253"],"Ensembl":"ENSG00000125375","Gene description":"Distal membrane arm assembly component 2 like","Uniprot":["Q99766"],"Chromosome":"14","Position":"50312324-50335558","Protein class":["Predicted intracellular proteins"],"Biological process":["ATP synthesis","Hydrogen ion transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"312.4","Late primary spermatocytes":"242.4","Late spermatids":"191.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"312.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"25496814.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"13100351.8"},"Antibody":["HPA062690"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA062690":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.27e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"}},{"Gene":"DMBT1","Gene synonym":["Gp-340","GP340","hensin","muclin","SALSA","vomeroglandin"],"Ensembl":"ENSG00000187908","Gene description":"Deleted in malignant brain tumors 1","Uniprot":["Q9UGM3"],"Chromosome":"10","Position":"122560665-122643736","Protein class":["Disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Antiviral defense","Differentiation","Host-virus interaction","Protein transport","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"19","RNA tissue specific nTPM":{"intestine":"1551.2","salivary gland":"487.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"357.6","Enteric stem cells":"135.1","Enteric transient amplifying cells":"307.8","Enterocytes":"142.7","Gastric progenitor cells":"717.7","Lacrimal acinar cells":"1081.6","Paneth cells":"228.2","Salivary acinar cells":"664.7","Salivary myoepithelial cells":"156.0","Submucosal glandular cells":"644.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"1081.6","Alveolar cells":"357.6","Glandular cells":"644.8","Proliferating cells":"717.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"5.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"194.1","Lung Adenocarcinoma (TCGA)":"109.7","Pancreatic Adenocarcinoma (TCGA)":"132.2","Rectum Adenocarcinoma (TCGA)":"107.3","Stomach Adenocarcinoma (TCGA)":"321.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"pancreatic cancer":"26.1"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Urothelial cells","Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"209995855.0"},"Antibody":["HPA040778"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centriolar satellite"],"Secretome location":"Secreted in other tissues","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":4,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":null,"Antibody RRID":{"HPA040778":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"DMRTB1","Gene synonym":[],"Ensembl":"ENSG00000143006","Gene description":"DMRT like family B with proline rich C-terminal 1","Uniprot":["Q96MA1"],"Chromosome":"1","Position":"53459399-53467488","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"73","RNA tissue specific nTPM":{"testis":"59.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"221.2","Early primary spermatocytes":"196.9","Early spermatids":"44.2","Late primary spermatocytes":"210.7","Late spermatids":"207.1","Oocytes":"55.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"221.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"64","RNA cell line specific nTPM":{"Gastric cancer":"6.4"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036490":null,"HPA058553":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DNAAF1","Gene synonym":["CILD13","DAU1","FLJ25330","LRRC50","ODA7","swt"],"Ensembl":"ENSG00000154099","Gene description":"Dynein axonemal assembly factor 1","Uniprot":["Q8NEP3"],"Chromosome":"16","Position":"84145287-84178767","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"23.0","fallopian tube":"21.4","testis":"42.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"156.3","Endometrial ciliated cells":"459.5","Ependymal cells":"656.2","Epididymal efferent duct ciliated cells":"312.7","Fallopian tube ciliated cells":"415.2","Late primary spermatocytes":"187.4","Plasma cells":"146.9","Respiratory ciliated cells":"768.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"768.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"686.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"38.8"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"choroid plexus":"18.4","medulla oblongata":"7.5","midbrain":"13.3","pons":"6.6","spinal cord":"4.6"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"2.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"1.0"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 78: Plasma cells - Antibody production & ER-stress response","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA074239":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":69,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035335":null,"HPA035336":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"}},{"Gene":"DNAAF11","Gene synonym":["CILD19","LRRC6","LRTP","tilB","TSLRP"],"Ensembl":"ENSG00000129295","Gene description":"Dynein axonemal assembly factor 11","Uniprot":["Q86X45"],"Chromosome":"8","Position":"132570416-132675592","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"46.5","testis":"24.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"315.3","Early spermatids":"189.2","Endometrial ciliated cells":"266.9","Ependymal cells":"440.4","Epididymal efferent duct ciliated cells":"207.8","Fallopian tube ciliated cells":"261.4","Late primary spermatocytes":"361.0","Respiratory ciliated cells":"397.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"440.4","Spermatogenic cell types":"361.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"485.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"2.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"2.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"8.9"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":9,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA028043":null,"HPA028058":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.58e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.27e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"}},{"Gene":"DNAAF2","Gene synonym":["C14orf104","CILD10","FLJ10563","KTU","PF13"],"Ensembl":"ENSG00000165506","Gene description":"Dynein axonemal assembly factor 2","Uniprot":["Q9NVR5"],"Chromosome":"14","Position":"49625174-49635244","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"7338789.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"29175","Protein tissue specific Intensity":{"fallopian tube":"3490829.9","lymphoid tissue":"2344122.3"},"Antibody":["HPA002894","HPA004113"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Golgi apparatus","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":8,"Subcellular main location":["Basal body","Cytosol"],"Subcellular additional location":["Nucleoli","Golgi apparatus","Primary cilium"],"Antibody RRID":{"HPA002894":null,"HPA004113":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.49e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.18e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"}},{"Gene":"DNAAF3","Gene synonym":["C19orf51","CILD2","FLJ36139","FLJ40069","PCD","PF22"],"Ensembl":"ENSG00000167646","Gene description":"Dynein axonemal assembly factor 3","Uniprot":["Q8N9W5"],"Chromosome":"19","Position":"55158661-55166722","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"fallopian tube":"38.3","testis":"61.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"99.5","Early spermatids":"51.5","Endometrial ciliated cells":"10.8","Ependymal cells":"23.6","Fallopian tube ciliated cells":"24.6","Late primary spermatocytes":"10.6","Late spermatids":"10.6","Respiratory ciliated cells":"50.7","Respiratory deuterosomal cells":"14.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Ciliated cells":"50.7","Myocytes":"99.5","Spermatogenic cell types":"51.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"23.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"15.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"11443119.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"22599","Protein tissue specific Intensity":{"fallopian tube":"2259949.6"},"Antibody":["HPA043222"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA043222":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"}},{"Gene":"DNAAF4","Gene synonym":["CILD25","DYX1C1","EKN1","FLJ37882"],"Ensembl":"ENSG00000256061","Gene description":"Dynein axonemal assembly factor 4","Uniprot":["Q8WXU2"],"Chromosome":"15","Position":"55410525-55508234","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Neurogenesis"],"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"27.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"39.0","Bergmann glia":"48.0","Brain excitatory neurons":"41.6","Brain inhibitory neurons":"51.1","Choroid plexus epithelial cells":"125.8","Distal convoluted tubule cells":"48.1","Endometrial ciliated cells":"33.9","Ependymal cells":"195.6","Loop of henle epithelial cells":"51.9","Other brain neurons":"68.0","Papillary tip epithelial cells":"39.2","Podocytes":"42.6","Proximal tubule cells":"56.3","Renal collecting duct principal cells":"71.9","Renal connecting tubule cells":"51.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"195.6","Ductal cells":"71.9","Glial cells":"48.0","Neuronal cells":"68.0","Renal nephron cells":"56.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"201.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"38302","Protein cell type specific Intensity":{"Fallopian tube cells":"3830158.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"151504","Protein tissue specific Intensity":{"fallopian tube":"15150436.4"},"Antibody":["HPA051048","HPA070577"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol","Connecting piece","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":7,"Subcellular main location":["Cytosol","Mid piece"],"Subcellular additional location":["Plasma membrane","Connecting piece","Principal piece"],"Antibody RRID":{"HPA051048":null,"HPA070577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"}},{"Gene":"DNAAF6","Gene synonym":["CXorf41","MGC35261","NYSAR97","PIH1D3","TWISTER"],"Ensembl":"ENSG00000080572","Gene description":"Dynein axonemal assembly factor 6","Uniprot":["Q9NQM4"],"Chromosome":"X","Position":"107206611-107244247","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"choroid plexus":"3.8","fallopian tube":"10.2","testis":"11.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"174.4","Endometrial ciliated cells":"61.1","Ependymal cells":"32.7","Epididymal efferent duct ciliated cells":"40.3","Fallopian tube ciliated cells":"97.0","Late primary spermatocytes":"147.7","Respiratory ciliated cells":"150.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"35","RNA single cell type group specific nCPM":{"Ciliated cells":"150.0","Spermatogenic cell types":"174.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"ependymal cell":"45.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"4.0"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7185","Protein cell type specific Intensity":{"Fallopian tube cells":"718548.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3816","Protein tissue specific Intensity":{"fallopian tube":"381559.0"},"Antibody":["HPA051099","HPA072496"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Primary cilium","Primary cilium tip","Basal body","Cytosol","Acrosome","Equatorial segment"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":11,"Subcellular main location":["Golgi apparatus","Primary cilium","Acrosome"],"Subcellular additional location":["Nucleoplasm","Primary cilium tip","Basal body","Cytosol","Equatorial segment"],"Antibody RRID":{"HPA051099":null,"HPA072496":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"}},{"Gene":"DNAAF8","Gene synonym":["C16orf71","DKFZp686H2240","FLJ43261"],"Ensembl":"ENSG00000166246","Gene description":"Dynein axonemal assembly factor 8","Uniprot":["Q8IYS4"],"Chromosome":"16","Position":"4734344-4749396","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"21.2","testis":"73.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"45.0","Early spermatids":"30.5","Ependymal cells":"38.9","Epididymal efferent duct ciliated cells":"38.6","Fallopian tube ciliated cells":"50.2","Late primary spermatocytes":"241.7","Late spermatids":"98.6","Respiratory ciliated cells":"68.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"68.4","Spermatogenic cell types":"241.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"17.0","ependymal cell":"49.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049468":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"}},{"Gene":"DNAH1","Gene synonym":["DNAHC1","HDHC7","HL-11","HL11","XLHSRF-1"],"Ensembl":"ENSG00000114841","Gene description":"Dynein axonemal heavy chain 1","Uniprot":["Q9P2D7"],"Chromosome":"3","Position":"52316319-52400492","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"106.7","Respiratory ciliated cells":"101.1","Tuft cells":"46.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"106.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"106.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036805":null,"HPA036806":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.22e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.72e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA039066":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DNAH12","Gene synonym":["DHC3","DLP12","DNAH12L","DNAH7L","Dnahc3","DNHD2","FLJ40427","FLJ44290","hdhc3","HL-19"],"Ensembl":"ENSG00000174844","Gene description":"Dynein axonemal heavy chain 12","Uniprot":["Q6ZR08"],"Chromosome":"3","Position":"57293699-57544344","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Motor protein"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"8.7","fallopian tube":"9.7","lung":"3.5","testis":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"457.4","Endometrial ciliated cells":"1090.3","Ependymal cells":"1304.3","Epididymal efferent duct ciliated cells":"350.9","Fallopian tube ciliated cells":"851.1","Respiratory ciliated cells":"2668.6","Respiratory deuterosomal cells":"235.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"23","RNA single cell type group specific nCPM":{"Ciliated cells":"2668.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"31","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"367.3","ependymal cell":"1354.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Centrosome","Mid piece","Principal piece"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037493":null,"HPA058203":null,"HPA061365":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"}},{"Gene":"DNAH14","Gene synonym":["C1orf67","DKFZp781B1548","Dnahc14","HL-18","HL18","MGC27277"],"Ensembl":"ENSG00000185842","Gene description":"Dynein axonemal heavy chain 14","Uniprot":["Q0VDD8"],"Chromosome":"1","Position":"224896262-225399292","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"18.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"359.7","Gonadotrophs":"374.6","Lactotrophs":"479.0","Retinal amacrine cells":"372.0","Somatotrophs":"438.7","Thyrotrophs":"448.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"479.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA027718":null,"HPA028545":null,"HPA031379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.46e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"}},{"Gene":"DNAH17","Gene synonym":["DNAHL1","DNEL2","FLJ40457"],"Ensembl":"ENSG00000187775","Gene description":"Dynein axonemal heavy chain 17","Uniprot":["Q9UFH2"],"Chromosome":"17","Position":"78423697-78577396","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"retina":"2.3","testis":"5.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"223.6","Early spermatids":"69.5","Late primary spermatocytes":"58.8","Late spermatids":"59.3","monocytes":"43.9","Neutrophils":"94.8","Retinal bipolar cells":"312.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"312.1","Neutrophils":"94.8","Spermatogenic cell types":"69.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"76.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"2.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA024354":null,"HPA076261":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DNAH2","Gene synonym":["DNHD3","FLJ46675","KIAA1503"],"Ensembl":"ENSG00000183914","Gene description":"Dynein axonemal heavy chain 2","Uniprot":["Q9P225"],"Chromosome":"17","Position":"7717744-7833742","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"12.3","parathyroid gland":"9.9","retina":"19.2","testis":"6.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"56.8","Ependymal cells":"204.4","Epicardial cells":"38.7","Epididymal efferent duct ciliated cells":"44.1","Fallopian tube ciliated cells":"108.0","Respiratory ciliated cells":"255.2","Rod photoreceptor cells":"256.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"255.2","Neuronal cells":"256.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"211.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":4,"Subcellular main location":["Microtubules","Primary cilium","Flagellar centriole","End piece"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Basal body"],"Antibody RRID":{"HPA067103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.90e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"}},{"Gene":"DNAH6","Gene synonym":["Dnahc6","DNHL1","FLJ37357","HL-2"],"Ensembl":"ENSG00000115423","Gene description":"Dynein axonemal heavy chain 6","Uniprot":["Q9C0G6"],"Chromosome":"2","Position":"84516455-84819589","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"5.0","fallopian tube":"5.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1073.6","Corticotrophs":"299.0","Endometrial ciliated cells":"537.7","Ependymal cells":"1671.8","Epididymal efferent duct ciliated cells":"371.4","Fallopian tube ciliated cells":"649.1","Respiratory ciliated cells":"1137.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"1671.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"779.6","ependymal cell":"1841.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Plasma membrane","Centriolar satellite","Basal body","Connecting piece","Mid piece"],"Subcellular additional location":["Primary cilium tip","Calyx"],"Antibody RRID":{"HPA036391":null,"HPA061401":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"}},{"Gene":"DNAH7","Gene synonym":["KIAA0944"],"Ensembl":"ENSG00000118997","Gene description":"Dynein axonemal heavy chain 7","Uniprot":["Q8WXX0"],"Chromosome":"2","Position":"195737703-196068837","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"19.8","testis":"10.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"361.4","Choroid plexus epithelial cells":"1118.9","Endometrial ciliated cells":"860.4","Ependymal cells":"1863.8","Epididymal efferent duct ciliated cells":"576.7","Fallopian tube ciliated cells":"737.9","Respiratory ciliated cells":"1361.5","Somatotrophs":"327.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"1863.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"912.2","ependymal cell":"2037.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Annulus"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA034724":null,"HPA044070":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"}},{"Gene":"DNAH8","Gene synonym":["hdhc9"],"Ensembl":"ENSG00000124721","Gene description":"Dynein axonemal heavy chain 8","Uniprot":["Q96JB1"],"Chromosome":"6","Position":"38715311-39030792","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"2.4","prostate":"2.0","testis":"7.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"36.3","Early primary spermatocytes":"66.0","Early spermatids":"30.0","Foveolar cells":"29.9","Late primary spermatocytes":"85.4","Late spermatids":"20.9","Plasma cells":"16.2","Prostatic glandular cells":"28.2","Undifferentiated spermatogonia":"42.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"29.9","Glandular cells":"28.2","Spermatogenic cell types":"85.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"23.4","hippocampal dentate gyrus":"13.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"7.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"basophil":"2.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"2.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"2.5"},"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA028447":null,"HPA030108":null,"HPA030109":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DNAH9","Gene synonym":["DNAH17L","Dnahc9","DNAL1","DYH9","HL-20","HL20","KIAA0357"],"Ensembl":"ENSG00000007174","Gene description":"Dynein axonemal heavy chain 9","Uniprot":["Q9NYC9"],"Chromosome":"17","Position":"11598470-11969748","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.5","choroid plexus":"11.9","fallopian tube":"33.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"346.2","Endometrial ciliated cells":"690.8","Ependymal cells":"3138.6","Epididymal efferent duct ciliated cells":"595.6","Fallopian tube ciliated cells":"904.2","Respiratory ciliated cells":"1781.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"26","RNA single cell type group specific nCPM":{"Ciliated cells":"3138.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"12","RNA single nuclei brain specific nCPM":{"ependymal cell":"3176.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"13.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Bone cancer":"1.9","skin cancer":"1.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Flagellar centriole","End piece"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020639":null,"HPA052641":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.75e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"}},{"Gene":"DNAI1","Gene synonym":["CILD1","DIC1","PCD"],"Ensembl":"ENSG00000122735","Gene description":"Dynein axonemal intermediate chain 1","Uniprot":["Q9UI46"],"Chromosome":"9","Position":"34457414-34520988","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"65.4","fallopian tube":"31.9","testis":"31.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"296.0","Endometrial ciliated cells":"278.0","Ependymal cells":"572.4","Epididymal efferent duct ciliated cells":"251.0","Fallopian tube ciliated cells":"296.2","Gonadotrophs":"145.2","Lactotrophs":"95.2","Late primary spermatocytes":"155.1","Respiratory ciliated cells":"495.3","Somatotrophs":"127.3","Thyrotrophs":"128.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"572.4","Pituitary endocrine cells":"145.2","Spermatogenic cell types":"155.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"228.9","ependymal cell":"610.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"9.5"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"59.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"1.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Primary cilium","Mid piece","End piece"],"Subcellular additional location":["Vesicles","Principal piece"],"Antibody RRID":{"HPA021649":null,"HPA021843":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"}},{"Gene":"DNAI2","Gene synonym":["CILD9","DIC2"],"Ensembl":"ENSG00000171595","Gene description":"Dynein axonemal intermediate chain 2","Uniprot":["Q9GZS0"],"Chromosome":"17","Position":"74274234-74314884","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"28.6","testis":"18.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"169.2","Ependymal cells":"212.4","Epididymal efferent duct ciliated cells":"187.2","Fallopian tube ciliated cells":"253.1","Late primary spermatocytes":"124.2","Respiratory ciliated cells":"480.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"480.2","Spermatogenic cell types":"124.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"216.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"1.2","Uterine Corpus Endometrial Carcinoma (TCGA)":"1.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"NK-cell":"3.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"NK-cells":"3.8"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Connecting piece","Mid piece"],"Subcellular additional location":["Calyx"],"Antibody RRID":{"CAB006245":null,"HPA027105":null,"HPA050565":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"DNAI3","Gene synonym":["DIC3","FLJ30067","NYD-SP29","WDR63"],"Ensembl":"ENSG00000162643","Gene description":"Dynein axonemal intermediate chain 3","Uniprot":["Q8IWG1"],"Chromosome":"1","Position":"84999147-85133138","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"adrenal gland":"20.6","choroid plexus":"40.0","fallopian tube":"13.6","testis":"17.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"179.5","Choroid plexus epithelial cells":"149.2","Endometrial ciliated cells":"212.6","Ependymal cells":"450.8","Epicardial cells":"138.7","Epididymal efferent duct ciliated cells":"219.1","Fallopian tube ciliated cells":"281.9","Gonadotrophs":"103.1","Late primary spermatocytes":"148.8","Melanocytes":"363.6","Respiratory ciliated cells":"285.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"179.5","Ciliated cells":"450.8","Pigment cells":"363.6","Spermatogenic cell types":"148.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"143.1","ependymal cell":"501.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"7.8","Uterine Corpus Endometrial Carcinoma (TCGA)":"6.8"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"49.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"3.3"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Connecting piece"],"Subcellular additional location":["Perinuclear theca","Calyx","Mid piece"],"Antibody RRID":{"HPA038526":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"}},{"Gene":"DNAI4","Gene synonym":["DIC4","FLJ23129","WDR78"],"Ensembl":"ENSG00000152763","Gene description":"Dynein axonemal intermediate chain 4","Uniprot":["Q5VTH9"],"Chromosome":"1","Position":"66812885-66924856","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"19.4","fallopian tube":"26.1","testis":"32.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"541.2","Endometrial ciliated cells":"267.4","Ependymal cells":"819.2","Epididymal efferent duct ciliated cells":"375.6","Fallopian tube ciliated cells":"470.1","Late primary spermatocytes":"302.8","Respiratory ciliated cells":"665.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"819.2","Spermatogenic cell types":"302.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"433.6","ependymal cell":"884.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"NK-cell":"3.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"NK-cells":"3.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA054315":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.70e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.55e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"DNAI7","Gene synonym":["CASC1","CFAP94","FLJ10921","LAS1","PPP1R54"],"Ensembl":"ENSG00000118307","Gene description":"Dynein axonemal intermediate chain 7","Uniprot":["Q6TDU7"],"Chromosome":"12","Position":"25108289-25195162","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"13.5","fallopian tube":"13.2","testis":"21.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"355.5","Early spermatids":"373.3","Endometrial ciliated cells":"198.2","Ependymal cells":"589.2","Epididymal efferent duct ciliated cells":"201.5","Fallopian tube ciliated cells":"348.6","Late primary spermatocytes":"315.9","Respiratory ciliated cells":"503.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"589.2","Spermatogenic cell types":"373.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"317.6","ependymal cell":"660.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"4.2"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA039662":null,"HPA040141":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.89e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.15e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.51e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"}},{"Gene":"DNAJA1","Gene synonym":["dj-2","hdj-2","HSJ2","HSPF4","NEDD7"],"Ensembl":"ENSG00000086061","Gene description":"DnaJ heat shock protein family (Hsp40) member A1","Uniprot":["P31689"],"Chromosome":"9","Position":"33025273-33039907","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001306","CAB033665"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"93000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":112,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Microtubules"],"Antibody RRID":{"CAB033665":null,"HPA001306":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"}},{"Gene":"DNAJB1","Gene synonym":["Hsp40","HSPF1","RSPH16B","Sis1"],"Ensembl":"ENSG00000132002","Gene description":"DnaJ heat shock protein family (Hsp40) member B1","Uniprot":["P25685"],"Chromosome":"19","Position":"14514769-14560391","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":["Chaperone"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct absorptive cells":"1640.6","Esophageal apical cells":"2850.7","Pancreatic duct cells":"2411.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2850.7","Ductal cells":"2411.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"153.4","leukocyte":"169.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"90329820.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017450","HPA063247"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"32000","Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":106,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB017450":null,"HPA063247":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.95e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"DNAJB12","Gene synonym":["DJ10","FLJ20027"],"Ensembl":"ENSG00000148719","Gene description":"DnaJ heat shock protein family (Hsp40) member B12","Uniprot":["Q9NXW2"],"Chromosome":"10","Position":"72332830-72355149","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Host-virus interaction"],"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"347.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"347.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"21987181.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"8526146.6"},"Antibody":["HPA010642","HPA072702"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":31,"Subcellular main location":["Nuclear membrane","Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA010642":null,"HPA072702":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"DNAJB13","Gene synonym":["RSPH16A","TSARG6"],"Ensembl":"ENSG00000187726","Gene description":"DnaJ heat shock protein family (Hsp40) member B13","Uniprot":["P59910"],"Chromosome":"11","Position":"73951026-73970366","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Chaperone"],"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"25.4","fallopian tube":"50.1","testis":"18.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"52.8","Early spermatids":"76.8","Endometrial ciliated cells":"170.5","Ependymal cells":"110.1","Epididymal efferent duct ciliated cells":"141.0","Fallopian tube ciliated cells":"273.2","Late primary spermatocytes":"91.4","Late spermatids":"80.8","Oocytes":"41.4","Respiratory ciliated cells":"137.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"273.2","Spermatogenic cell types":"91.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"23","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"40.5","ependymal cell":"113.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"21.4","Uterine Corpus Endometrial Carcinoma (TCGA)":"25.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"23.9"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"125354","Protein cell type specific Intensity":{"Fallopian tube cells":"12535350.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"108377","Protein tissue specific Intensity":{"fallopian tube":"10837675.2"},"Antibody":["HPA052465","HPA061330"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoli","Nucleoli rim","Mitotic chromosome","Vesicles","Plasma membrane","Primary cilium","Primary cilium tip","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":10,"Subcellular main location":["Plasma membrane","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Nucleoli","Nucleoli rim","Mitotic chromosome","Vesicles","Primary cilium","Primary cilium tip"],"Antibody RRID":{"HPA052465":null,"HPA061330":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"}},{"Gene":"DNAJB9","Gene synonym":["MDG1"],"Ensembl":"ENSG00000128590","Gene description":"DnaJ heat shock protein family (Hsp40) member B9","Uniprot":["Q9UBS3"],"Chromosome":"7","Position":"108569867-108574850","Protein class":["Predicted intracellular proteins"],"Biological process":["Unfolded protein response"],"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"391.2","Epididymal efferent duct absorptive cells":"317.7","Epididymal principal cells":"332.4","Late primary spermatocytes":"292.0","Late spermatids":"289.7","Plasma cells":"397.8","Syncytiotrophoblasts":"828.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"828.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"67768.9","Neurons":"183709.9","Oocytes":"139195.8","Pancreas epithelial cells":"123086.1","Pancreatic islets":"219362.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"336418.4","salivary gland":"286458.4"},"Antibody":["HPA040967","HPA041553"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":65,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040967":null,"HPA041553":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.74e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"}},{"Gene":"DNAJC10","Gene synonym":["ERdj5","PDIA19"],"Ensembl":"ENSG00000077232","Gene description":"DnaJ heat shock protein family (Hsp40) member C10","Uniprot":["Q8IXB1"],"Chromosome":"2","Position":"182716255-182794464","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"107.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"434.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"434.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"35495818.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"22118229.2"},"Antibody":["HPA031111"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031111":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.35e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.91e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"}},{"Gene":"DNAJC15","Gene synonym":["DNAJD1","MCJ"],"Ensembl":"ENSG00000120675","Gene description":"DnaJ heat shock protein family (Hsp40) member C15","Uniprot":["Q9Y5T4"],"Chromosome":"13","Position":"43023203-43114213","Protein class":["Disease related genes","Predicted membrane proteins"],"Biological process":["Protein transport","Translocation","Transport"],"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"437.9","Extravillous trophoblasts":"438.1","Gastric progenitor cells":"437.1","Late primary spermatocytes":"731.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"731.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1334","Protein tissue specific Intensity":{"salivary gland":"133413.4"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"DNAJC18","Gene synonym":["MGC29463"],"Ensembl":"ENSG00000170464","Gene description":"DnaJ heat shock protein family (Hsp40) member C18","Uniprot":["Q9H819"],"Chromosome":"5","Position":"139408588-139444491","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"73.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"503.4","Late spermatids":"1921.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"40","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1921.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"8.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Lung - Endothelial cells","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1985","Protein cell type specific Intensity":{"Neurons":"198541.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036538","HPA060154"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cell Junctions","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":3,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036538":null,"HPA060154":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.00e-8"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"}},{"Gene":"DNAJC2","Gene synonym":["MPHOSPH11","MPP11","ZRF1","ZUO1","zuotin"],"Ensembl":"ENSG00000105821","Gene description":"DnaJ heat shock protein family (Hsp40) member C2","Uniprot":["Q99543"],"Chromosome":"7","Position":"103312289-103344830","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Chaperone","Chromatin regulator"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"218.9","Late primary spermatocytes":"353.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"353.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"61.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"11233627.4"},"Antibody":["HPA020454"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":145,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020454":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.66e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.90e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"}},{"Gene":"DNAJC21","Gene synonym":["DNAJA5","GS3","JJJ1"],"Ensembl":"ENSG00000168724","Gene description":"DnaJ heat shock protein family (Hsp40) member C21","Uniprot":["Q5F1R6"],"Chromosome":"5","Position":"34929559-34958964","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":11,"Subcellular main location":["Nucleoli","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040789":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.96e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"}},{"Gene":"DNAJC24","Gene synonym":["DPH4","JJJ3","ZCSL3"],"Ensembl":"ENSG00000170946","Gene description":"DnaJ heat shock protein family (Hsp40) member C24","Uniprot":["Q6P3W2"],"Chromosome":"11","Position":"31369840-31432835","Protein class":["Predicted intracellular proteins"],"Biological process":["Electron transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"218.9","Late primary spermatocytes":"139.1","Late spermatids":"356.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"356.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"165","Protein tissue specific Intensity":{"Stomach":"16480.1"},"Antibody":["HPA020025","HPA025237"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 27: T-cells - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020025":null,"HPA025237":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.99e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.94e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"DNAJC27","Gene synonym":["RabJS","RBJ"],"Ensembl":"ENSG00000115137","Gene description":"DnaJ heat shock protein family (Hsp40) member C27","Uniprot":["Q9NZQ0"],"Chromosome":"2","Position":"24943636-24972094","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"20.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Granulosa cells":"128.1","Vascular smooth muscle cells":"109.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":6,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036815":null,"HPA036816":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.57e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"DNAJC28","Gene synonym":["C21orf55","C21orf78"],"Ensembl":"ENSG00000177692","Gene description":"DnaJ heat shock protein family (Hsp40) member C28","Uniprot":["Q9NX36"],"Chromosome":"21","Position":"33485530-33491716","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"6.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"3.0","Bergmann glia":"5.5","Brain excitatory neurons":"4.4","Brain inhibitory neurons":"4.0","Choroid plexus epithelial cells":"5.1","Distal convoluted tubule cells":"2.7","Early spermatids":"3.1","Late primary spermatocytes":"3.2","Loop of henle epithelial cells":"3.3","Oligodendrocyte progenitor cells":"2.6","Oligodendrocytes":"3.7","Other brain neurons":"4.1","Podocytes":"3.6","Proximal tubule cells":"4.4","Renal collecting duct principal cells":"2.6","Renal connecting tubule cells":"3.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"5.1","Ductal cells":"3.6","Glial cells":"5.5","Neuronal cells":"4.4","Renal nephron cells":"4.4","Spermatogenic cell types":"3.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"1644664.6","Neurons":"3665819.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018003","HPA030076","HPA077153"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":1,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA018003":null,"HPA030076":null,"HPA077153":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.27e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DNAJC30","Gene synonym":["WBSCR18"],"Ensembl":"ENSG00000176410","Gene description":"DnaJ heat shock protein family (Hsp40) member C30","Uniprot":["Q96LL9"],"Chromosome":"7","Position":"73680918-73683453","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["ATP synthesis"],"Molecular function":["Chaperone"],"Disease involvement":["Disease variant","Leber hereditary optic neuropathy","Primary mitochondrial disease","Williams-Beuren syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"124.4","Late primary spermatocytes":"133.2","Late spermatids":"360.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"360.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"410315.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"680365.6"},"Antibody":["HPA017318"],"Reliability (IH)":null,"Reliability (Mouse Brain)":"Supported","Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":82,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA017318":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.57e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.40e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.56e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"}},{"Gene":"DNAJC5B","Gene synonym":["CSP-beta","MGC26226"],"Ensembl":"ENSG00000147570","Gene description":"DnaJ heat shock protein family (Hsp40) member C5 beta","Uniprot":["Q9UF47"],"Chromosome":"8","Position":"66021553-66101245","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"57.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"1214.9","Late spermatids":"4363.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"141","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4363.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"CGE interneuron":"3.3","lower rhombic lip":"1.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"white matter":"1.2"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"5.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"5.8"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"15.5","Rhabdoid":"5.2"},"RNA tissue cell type enrichment":["Lung - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 17: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"}},{"Gene":"DNAJC5G","Gene synonym":["CSP-gamma","FLJ40417"],"Ensembl":"ENSG00000163793","Gene description":"DnaJ heat shock protein family (Hsp40) member C5 gamma","Uniprot":["Q8N7S2"],"Chromosome":"2","Position":"27275433-27281499","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"epididymis":"44.2","testis":"21.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"30.6","Differentiating spermatogonia":"37.7","Early primary spermatocytes":"136.6","Early spermatids":"60.9","Epididymal principal cells":"180.2","Late primary spermatocytes":"184.1","Late spermatids":"122.1","Sertoli cells":"44.8","Undifferentiated spermatogonia":"42.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"180.2","Spermatogenic cell types":"184.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"amygdala excitatory":"14.3","deep-layer intratelencephalic":"22.2","hippocampal dentate gyrus":"24.5","miscellaneous":"6.3","upper-layer intratelencephalic":"24.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041445"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041445":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"DNAL1","Gene synonym":["1700010H15RiK","C14orf168","CILD16","MGC12435"],"Ensembl":"ENSG00000119661","Gene description":"Dynein axonemal light chain 1","Uniprot":["Q4LDG9"],"Chromosome":"14","Position":"73644875-73703732","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"51.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"306.5","Endometrial ciliated cells":"161.4","Ependymal cells":"116.2","Epididymal efferent duct ciliated cells":"138.1","Fallopian tube ciliated cells":"188.8","Late primary spermatocytes":"521.6","Respiratory ciliated cells":"231.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"231.7","Spermatogenic cell types":"521.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"144.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1220524.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"34679","Protein tissue specific Intensity":{"cerebral cortex":"2782646.2","fallopian tube":"4153079.9"},"Antibody":["HPA053129","HPA060974"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centriolar satellite","Centrosome","Basal body","Cytosol","Acrosome","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Nucleoplasm","Basal body","Cytosol","Principal piece"],"Subcellular additional location":["Centriolar satellite","Centrosome","Acrosome","Mid piece","End piece"],"Antibody RRID":{"HPA053129":null,"HPA060974":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.72e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.28e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"}},{"Gene":"DNAL4","Gene synonym":["dJ327J16","PIG27"],"Ensembl":"ENSG00000100246","Gene description":"Dynein axonemal light chain 4","Uniprot":["O96015"],"Chromosome":"22","Position":"38778508-38794198","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"246.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"58","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"246.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"5359","Protein cell type specific Intensity":{"Fallopian tube cells":"535924.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1606","Protein tissue specific Intensity":{"cerebral cortex":"202418.3","fallopian tube":"118807.8"},"Antibody":["HPA003647"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Primary cilium transition zone","Centrosome","Basal body","Cytosol","Acrosome","Equatorial segment","Perinuclear theca","Calyx","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":24,"Subcellular main location":["Centrosome","Basal body","Acrosome"],"Subcellular additional location":["Nucleoplasm","Nucleoli","Primary cilium transition zone","Cytosol","Equatorial segment","Perinuclear theca","Calyx","Principal piece"],"Antibody RRID":{"HPA003647":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"}},{"Gene":"DNALI1","Gene synonym":["dJ423B22.5","hp28","P28"],"Ensembl":"ENSG00000163879","Gene description":"Dynein axonemal light intermediate chain 1","Uniprot":["O14645"],"Chromosome":"1","Position":"37556919-37566857","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"75.0","fallopian tube":"51.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"657.8","Endometrial ciliated cells":"336.5","Epididymal efferent duct ciliated cells":"363.9","Fallopian tube ciliated cells":"391.2","Late primary spermatocytes":"514.2","Late spermatids":"1404.5","Respiratory ciliated cells":"447.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Ciliated cells":"447.7","Spermatogenic cell types":"1404.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"70.6","ependymal cell":"177.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"8.1"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":63,"Subcellular main location":["Primary cilium","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Nucleoplasm","Microtubules","Cytokinetic bridge","Mitotic spindle"],"Antibody RRID":{"HPA028305":null,"HPA031633":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.56e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.17e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"DNASE2B","Gene synonym":["DLAD"],"Ensembl":"ENSG00000137976","Gene description":"Deoxyribonuclease 2 beta","Uniprot":["Q8WZ79"],"Chromosome":"1","Position":"84398484-84415018","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Endonuclease","Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"25","RNA tissue specific nTPM":{"salivary gland":"160.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Lacrimal acinar cells":"33.5","Salivary acinar cells":"98.4","Salivary myoepithelial cells":"52.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Acinar cells":"98.4","Secretory gland support":"52.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"19.4","Skin Cutaneous Melanoma (TCGA)":"5.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"8.4","prostate cancer":"4.1"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":1,"Subcellular main location":["Mid piece"],"Subcellular additional location":["Annulus"],"Antibody RRID":{"HPA039698":null,"HPA040267":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.65e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"43000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":12,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA064121":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.01e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"DNTT","Gene synonym":["TDT"],"Ensembl":"ENSG00000107447","Gene description":"DNA nucleotidylexotransferase","Uniprot":["P04053"],"Chromosome":"10","Position":"96304409-96338564","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Terminal addition"],"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"lymphoid tissue":"306.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Thymocytes":"160.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"T-cells":"160.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"2.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"225.7"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036532":null,"HPA044194":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DNTTIP1","Gene synonym":["C20orf167","dJ447F3.4","Tdif1"],"Ensembl":"ENSG00000101457","Gene description":"Deoxynucleotidyltransferase terminal interacting protein 1","Uniprot":["Q9H147"],"Chromosome":"20","Position":"45791954-45811427","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"160.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"125.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"43.4","granulocytes":"125.6","monocytes":"51.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"907447.3","Granulosa cells":"695323.7","Keratinocytes":"473943.5","Neutrophils":"1855753.3","T-cells":"725248.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"4308537.8","intestine":"5907355.1"},"Antibody":["HPA045496"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli rim","Mitotic chromosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":35,"Subcellular main location":["Nucleoli","Nucleoli rim","Mitotic chromosome"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA045496":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.26e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.82e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.76e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"}},{"Gene":"DOC2A","Gene synonym":[],"Ensembl":"ENSG00000149927","Gene description":"Double C2 domain alpha","Uniprot":["Q14183"],"Chromosome":"16","Position":"30005514-30023270","Protein class":["Predicted intracellular proteins"],"Biological process":["Exocytosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"91.7","testis":"35.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"363.6","Ependymal cells":"226.0","Late primary spermatocytes":"130.5","Late spermatids":"407.6","Respiratory ciliated cells":"146.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"226.0","Spermatogenic cell types":"407.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"222.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"20.6","Kidney Renal Papillary Cell Carcinoma (TCGA)":"20.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":12,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA065676":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"}},{"Gene":"DONSON","Gene synonym":["B17","C21orf60","C2TA","DKFZP434M035"],"Ensembl":"ENSG00000159147","Gene description":"DNA replication fork stabilization factor DONSON","Uniprot":["Q9NYP3"],"Chromosome":"21","Position":"33559542-33588706","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Cardiomyocytes":"513.7","Epicardial cells":"745.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"745.9","Myocytes":"513.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":6,"Subcellular main location":["Nucleoplasm","Cell Junctions"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039558":null,"HPA049033":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.60e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"}},{"Gene":"DOT1L","Gene synonym":["DOT1","KIAA1814","KMT4"],"Ensembl":"ENSG00000104885","Gene description":"DOT1 like histone lysine methyltransferase","Uniprot":["Q8TEK3"],"Chromosome":"19","Position":"2163933-2232578","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chromatin regulator","DNA-binding","Methyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"49.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"140.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"159","Protein cell type specific Intensity":{"Granulosa cells":"15925.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011875","HPA071217","HPA074977"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA011875":null,"HPA071217":null,"HPA074977":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.87e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.69e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"}},{"Gene":"DPCD","Gene synonym":["DKFZP566F084","RP11-529I10.4"],"Ensembl":"ENSG00000166171","Gene description":"Deleted in primary ciliary dyskinesia homolog (mouse)","Uniprot":["Q9BVM2"],"Chromosome":"10","Position":"101570560-101609662","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"141.8","testis":"135.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"497.6","Epididymal efferent duct ciliated cells":"254.8","Fallopian tube ciliated cells":"310.1","Late primary spermatocytes":"886.4","Late spermatids":"1610.2","Respiratory ciliated cells":"316.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1610.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"20.3","intermediate monocyte":"22.3","myeloid DC":"29.7","non-classical monocyte":"9.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"14","RNA blood lineage specific nTPM":{"dendritic cells":"29.7","monocytes":"22.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Liver - Vascular endothelial cells","Lung - Respiratory ciliated cells","Pituitary gland - Somatotropes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"30968165.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"51421","Protein tissue specific Intensity":{"fallopian tube":"5142050.1"},"Antibody":["HPA036603","HPA036604"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane","Mitotic spindle","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":16,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Plasma membrane","Mitotic spindle","Primary cilium"],"Antibody RRID":{"HPA036603":null,"HPA036604":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"}},{"Gene":"DPEP2NB","Gene synonym":[],"Ensembl":"ENSG00000263201","Gene description":"DPEP2 neighbor","Uniprot":["A0A0U1RQF7"],"Chromosome":"16","Position":"68013436-68015911","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"3.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Syncytiotrophoblasts":"84.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Trophoblast cells":"84.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"1.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"granulocytes":"1.0"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":29,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA066790":null,"HPA070601":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035287":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.26e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"DPP4","Gene synonym":["ADCP2","CD26","DPPIV"],"Ensembl":"ENSG00000197635","Gene description":"Dipeptidyl peptidase 4","Uniprot":["P27487"],"Chromosome":"2","Position":"161992245-162074394","Protein class":["CD markers","Enzymes","FDA approved drug targets","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins","Transporters"],"Biological process":["Cell adhesion","Host-virus interaction"],"Molecular function":["Aminopeptidase","Hydrolase","Protease","Receptor","Serine protease"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"130.0","parathyroid gland":"146.6","placenta":"126.0","prostate":"100.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"112.8","Cytotrophoblasts":"202.9","Endometrial glandular cells":"162.5","Enterocytes":"347.6","Migrating cytotrophoblasts":"186.2","Neuroendocrine cells":"100.9","Prostatic glandular cells":"367.3","Salivary acinar cells":"190.5","Syncytiotrophoblasts":"238.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"190.5","Enterocytes":"347.6","Glandular cells":"367.3","Trophoblast cells":"238.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"38.5","leukocyte":"104.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"108.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"52.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"T-cells":"52.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"54.4"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":643000000,"Blood concentration - Conc. blood MS [pg\/L]":"84000000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":143,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB045970":null,"HPA068778":null,"HPA071236":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.36e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.32e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.06e-4"},"Cancer prognostics - 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Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"70522614.0"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA021282","CAB025541","HPA059381"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":"Secreted - unknown location","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2000000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"CAB025541":null,"HPA021282":null,"HPA059381":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"}},{"Gene":"DPP8","Gene synonym":["DP8","DPRP1","FLJ14920","FLJ20283","MGC26191","MSTP141"],"Ensembl":"ENSG00000074603","Gene description":"Dipeptidyl peptidase 8","Uniprot":["Q6V1X1"],"Chromosome":"15","Position":"65442463-65517704","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":["Aminopeptidase","Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"7237909.4"},"Antibody":["HPA008706"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008706":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.31e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.77e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.18e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"}},{"Gene":"DPY19L1","Gene synonym":["KIAA0877"],"Ensembl":"ENSG00000173852","Gene description":"Dpy-19 like C-mannosyltransferase 1","Uniprot":["Q2PZI1"],"Chromosome":"7","Position":"34927292-35038271","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"207.7","Early spermatids":"287.2","Platelets":"222.7","Sertoli cells":"160.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"287.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"375.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"2144217.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3034","Protein tissue specific Intensity":{"cerebral cortex":"223479.6","fallopian tube":"404513.5","lymphoid tissue":"282308.7"},"Antibody":["HPA059139"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":15,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA059139":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.40e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"}},{"Gene":"DPY19L2","Gene synonym":["FLJ32949","SPATA34"],"Ensembl":"ENSG00000177990","Gene description":"Dpy-19 like 2","Uniprot":["Q6NUT2"],"Chromosome":"12","Position":"63558913-63668939","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","Glycosyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"78.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"519.9","Distal convoluted tubule cells":"234.2","Ependymal cells":"176.5","Late spermatids":"174.3","Oligodendrocyte progenitor cells":"161.4","Pituitary stem cells":"192.8","Renal collecting duct intercalated cells":"335.1","Renal connecting tubule cells":"455.5","Somatotrophs":"163.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"455.5","Myocytes":"519.9","Renal nephron cells":"234.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"1.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"1.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA071264":null,"HPA078305":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.31e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.42e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.63e-4"}},{"Gene":"DPYS","Gene synonym":["DHPase"],"Ensembl":"ENSG00000147647","Gene description":"Dihydropyrimidinase","Uniprot":["Q14117"],"Chromosome":"8","Position":"104330324-104467055","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"40","RNA tissue specific nTPM":{"kidney":"186.1","liver":"446.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Hepatocytes":"686.5","Medullary thymic epithelial cells":"559.3","Mesothelial cells":"321.4","Proximal tubule cells":"389.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"321.4","Hepatocytes":"686.5","Renal nephron cells":"389.5","Secretory gland support":"559.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"thalamic excitatory":"106.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"126.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"1.2"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal cortex cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"171503651.6","Hepatocytes":"195859527.7","Proximal tubules":"201115522.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"323527270.6"},"Antibody":["HPA024785","HPA070814"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"750000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024785":null,"HPA070814":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.90e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.00e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DR1","Gene synonym":["NC2-BETA","NC2B","NCB2"],"Ensembl":"ENSG00000117505","Gene description":"Down-regulator of transcription 1","Uniprot":["Q01658"],"Chromosome":"1","Position":"93345907-93369493","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"283.0","Megakaryocytes":"185.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"283.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":75,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA050785":null,"HPA055308":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.52e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"}},{"Gene":"DRAP1","Gene synonym":["NC2-alpha"],"Ensembl":"ENSG00000175550","Gene description":"DR1 associated protein 1","Uniprot":["Q14919"],"Chromosome":"11","Position":"65919274-65921563","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"601.0","Esophageal apical cells":"426.3","Esophageal suprabasal cells":"472.9","Suprabasal keratinocytes":"791.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Suprabasal cells":"791.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"4859983.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"2405358.9"},"Antibody":["HPA006790"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA006790":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.26e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.94e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.42e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"}},{"Gene":"DRC1","Gene synonym":["C2orf39","CCDC164","CILD21","FLJ32660","MGC16372"],"Ensembl":"ENSG00000157856","Gene description":"Dynein regulatory complex subunit 1","Uniprot":["Q96MC2"],"Chromosome":"2","Position":"26401920-26456711","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"23.0","fallopian tube":"36.9","testis":"19.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"204.2","Early spermatids":"165.1","Endometrial ciliated cells":"218.8","Ependymal cells":"306.0","Epididymal efferent duct ciliated cells":"165.8","Fallopian tube ciliated cells":"293.7","Late primary spermatocytes":"116.8","Late spermatids":"499.1","Respiratory ciliated cells":"383.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Ciliated cells":"383.6","Spermatogenic cell types":"499.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"151.4","ependymal cell":"321.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"7.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"89","RNA blood cell specific nTPM":{"neutrophil":"8.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"89","RNA blood lineage specific nTPM":{"granulocytes":"8.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.9"},"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"10.3"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"216916","Protein cell type specific Intensity":{"Fallopian tube cells":"21691576.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"16736570.8"},"Antibody":["HPA051247"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium transition zone"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm","Primary cilium transition zone"],"Subcellular additional location":null,"Antibody RRID":{"HPA051247":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"}},{"Gene":"DRC3","Gene synonym":["CFAP134","DKFZP586M1120","LRRC48"],"Ensembl":"ENSG00000171962","Gene description":"Dynein regulatory complex subunit 3","Uniprot":["Q9H069"],"Chromosome":"17","Position":"17972813-18016889","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"25.1","fallopian tube":"57.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"84.9","Endometrial ciliated cells":"206.1","Ependymal cells":"311.1","Epididymal efferent duct ciliated cells":"238.8","Fallopian tube ciliated cells":"354.4","Respiratory ciliated cells":"459.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"459.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"340.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA036040":null,"HPA036041":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.53e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"}},{"Gene":"DRC7","Gene synonym":["C16orf50","CCDC135","CFAP50","DKFZp434I099","FAP50"],"Ensembl":"ENSG00000159625","Gene description":"Dynein regulatory complex subunit 7","Uniprot":["Q8IY82"],"Chromosome":"16","Position":"57694793-57731805","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"choroid plexus":"11.7","fallopian tube":"19.8","testis":"43.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"110.7","Endometrial ciliated cells":"54.4","Ependymal cells":"105.0","Epididymal efferent duct ciliated cells":"53.3","Fallopian tube ciliated cells":"74.0","Late primary spermatocytes":"179.0","Late spermatids":"206.8","Respiratory ciliated cells":"138.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"138.3","Spermatogenic cell types":"206.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"120.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"10.7","Uterine Corpus Endometrial Carcinoma (TCGA)":"8.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"basophil":"10.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"43","RNA blood lineage specific nTPM":{"granulocytes":"10.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.0"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"22625","Protein cell type specific Intensity":{"Fallopian tube cells":"2262544.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"31154","Protein tissue specific Intensity":{"fallopian tube":"3115440.8"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"}},{"Gene":"DRD2","Gene synonym":[],"Ensembl":"ENSG00000149295","Gene description":"Dopamine receptor D2","Uniprot":["P14416"],"Chromosome":"11","Position":"113409605-113475691","Protein class":["FDA approved drug targets","G-protein coupled receptors","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"62.0","pituitary gland":"56.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"51.3","Lactotrophs":"356.3","Other brain neurons":"27.3","Retinal horizontal cells":"162.3","Thyrotrophs":"87.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Neuronal cells":"162.3","Pituitary endocrine cells":"356.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"medium spiny neuron":"148.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"basal ganglia":"163.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"7.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pituitary gland - Lactotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"10","RNA mouse brain regional specific nTPM":{"basal ganglia":"205.4"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":"4","RNA pig brain regional specific nTPM":{"basal ganglia":"192.0"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"12842","Protein tissue specific Intensity":{"skeletal muscle":"1284210.2"},"Antibody":["HPA015139","HPA015691"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":"Supported","Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015139":null,"HPA015691":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DRG1","Gene synonym":["NEDD3"],"Ensembl":"ENSG00000185721","Gene description":"Developmentally regulated GTP binding protein 1","Uniprot":["Q9Y295"],"Chromosome":"22","Position":"31399604-31530634","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Dwarfism","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"149.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"703.5","Late primary spermatocytes":"1074.6","Late spermatids":"871.0","Oocytes":"419.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Oocytes":"419.1","Spermatogenic cell types":"1074.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":241,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001218":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.12e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.38e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.41e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.93e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.68e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"86000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":18,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA022128":null,"HPA074188":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DSG4","Gene synonym":["CDHF13","LAH"],"Ensembl":"ENSG00000175065","Gene description":"Desmoglein 4","Uniprot":["Q86SJ6"],"Chromosome":"18","Position":"31376777-31414912","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":["Disease variant","Hypotrichosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skin 1":"2.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"3.6","Colonocytes":"2.4","Early spermatids":"1.8","Epicardial cells":"2.3","Esophageal apical cells":"2.3","Esophageal suprabasal cells":"1.6","Late primary spermatocytes":"3.2","Late spermatids":"2.1","Medullary thymic epithelial cells":"7.2","Neuroendocrine cells":"2.2","Ocular epithelial cells":"1.9","Paneth cells":"7.7","Prostatic hillock cells":"2.9","Suprabasal keratinocytes":"5.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"2.9","Basal cells":"3.6","Secretory gland support":"7.7","Spermatogenic cell types":"3.2","Suprabasal cells":"5.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"colorectal cancer":"1.8"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"73000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059456":null,"HPA079244":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DSN1","Gene synonym":["C20orf172","dJ469A13.2","hKNL-3","KNL3","MIS13"],"Ensembl":"ENSG00000149636","Gene description":"DSN1 component of MIS12 kinetochore complex","Uniprot":["Q9H410"],"Chromosome":"20","Position":"36751791-36773818","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Chromosome partition","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"87.2","Differentiating spermatogonia":"81.1","Early primary spermatocytes":"147.5","Migrating cytotrophoblasts":"72.6","Oocytes":"101.3","Syncytiotrophoblasts":"90.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"147.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":51,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Nuclear bodies","Kinetochore","Cytosol"],"Antibody RRID":{"HPA002813":null,"HPA030627":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"}},{"Gene":"DTHD1","Gene synonym":["FLJ16686"],"Ensembl":"ENSG00000197057","Gene description":"Death domain containing 1","Uniprot":["Q6ZMT9"],"Chromosome":"4","Position":"36281616-36347511","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"12.9","lymphoid tissue":"3.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"560.8","Ependymal cells":"1132.4","Epididymal efferent duct ciliated cells":"279.5","Fallopian tube ciliated cells":"464.3","NK-cells":"206.0","Respiratory ciliated cells":"978.6","T-cells":"128.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"1132.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"1239.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"3.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"3.4"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"}},{"Gene":"DTL","Gene synonym":["CDT2","DCAF2","L2DTL","RAMP"],"Ensembl":"ENSG00000143476","Gene description":"Denticleless E3 ubiquitin protein ligase homolog","Uniprot":["Q9NZJ0"],"Chromosome":"1","Position":"212035553-212107400","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","DNA damage","DNA replication","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"13.8","intestine":"4.5","lymphoid tissue":"13.2","placenta":"3.7","testis":"12.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"54.5","Early primary spermatocytes":"78.0","Erythrocyte progenitors":"141.9","Extravillous trophoblasts":"38.6","Late primary spermatocytes":"59.5","Megakaryocyte progenitors":"117.8","Megakaryocyte-Erythroid progenitors":"49.9","Migrating cytotrophoblasts":"42.6","Monocyte progenitors":"102.1","Neutrophil progenitors":"77.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"141.9","Megakaryocytes":"117.8","Mononuclear phagocytes":"102.1","Neutrophils":"77.7","Spermatogenic cell types":"78.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"2.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"T-cells":"2.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"10144","Protein cell type specific Intensity":{"Granulosa cells":"1014440.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028016","HPA032023","HPA032031"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":36,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA028016":null,"HPA032023":null,"HPA032031":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.93e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.52e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.51e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"}},{"Gene":"DUS1L","Gene synonym":["DUS1","PP3111"],"Ensembl":"ENSG00000169718","Gene description":"Dihydrouridine synthase 1 like","Uniprot":["Q6P1R4"],"Chromosome":"17","Position":"82057506-82065887","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"155.1","Late spermatids":"227.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"227.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA023384":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.02e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.07e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.41e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042560":null,"HPA043528":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.07e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"DUS3L","Gene synonym":["DUS3","FLJ13896"],"Ensembl":"ENSG00000141994","Gene description":"Dihydrouridine synthase 3 like","Uniprot":["Q96G46"],"Chromosome":"19","Position":"5784832-5791225","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["mRNA processing","tRNA processing"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"130.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"130.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA041854":null,"HPA041944":null,"HPA062846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"}},{"Gene":"DUSP10","Gene synonym":["MKP-5","MKP5"],"Ensembl":"ENSG00000143507","Gene description":"Dual specificity phosphatase 10","Uniprot":["Q9Y6W6"],"Chromosome":"1","Position":"221701424-221742089","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"30.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"126.3","Mast cells":"210.8","Salivary ionocytes":"171.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mast cells":"210.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"238.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"19.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":15,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA016758":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.48e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.87e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"}},{"Gene":"DUSP13","Gene synonym":["BEDP","DUSP13A","DUSP13B","FLJ32450","MDSP","TMDP"],"Ensembl":"ENSG00000079393","Gene description":"Dual specificity phosphatase 13","Uniprot":["Q6B8I1","Q9UII6"],"Chromosome":"10","Position":"75094432-75109221","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"240.9","testis":"50.8","tongue":"104.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"441.8","Late primary spermatocytes":"265.8","Late spermatids":"83.1","Myonuclei":"140.7","Thymic myoid cells":"35.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Myocytes":"140.7","Spermatogenic cell types":"441.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"2.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"pons":"3.2"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"14","RNA blood cell specific nTPM":{"neutrophil":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"14","RNA blood lineage specific nTPM":{"granulocytes":"1.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"3.6"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DUSP15","Gene synonym":["bA243J16.5","bA243J16.6","C20orf57","FLJ20645","VHY"],"Ensembl":"ENSG00000149599","Gene description":"Dual specificity phosphatase 15","Uniprot":["Q9H1R2"],"Chromosome":"20","Position":"31847637-31870664","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"208.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1777.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1777.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"144.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"7.4"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3242","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"324168.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2888","Protein tissue specific Intensity":{"cerebral cortex":"288753.4"},"Antibody":["HPA076649"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA076649":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.44e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.35e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"}},{"Gene":"DUSP18","Gene synonym":["DUSP20"],"Ensembl":"ENSG00000167065","Gene description":"Dual specificity phosphatase 18","Uniprot":["Q8NEJ0"],"Chromosome":"22","Position":"30652051-30667887","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"225.7","Early spermatids":"143.8","Ependymal cells":"111.9","Fallopian tube ciliated cells":"97.6","Late primary spermatocytes":"119.8","Late spermatids":"643.9","Respiratory ciliated cells":"173.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Alveolar cells":"225.7","Ciliated cells":"173.2","Spermatogenic cell types":"643.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"126.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB034070":null,"HPA051349":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA021501":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"DUXB","Gene synonym":[],"Ensembl":"ENSG00000282757","Gene description":"Double homeobox B","Uniprot":["A0A1W2PPF3"],"Chromosome":"16","Position":"75693893-75701461","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"5.1","Cardiomyocytes":"8.7","Cone photoreceptor cells":"6.2","Epicardial cells":"9.1","Fibro-adipogenic progenitors":"7.6","Mesothelial cells":"3.3","Myonuclei":"5.6","Myosatellite cells":"4.2","Oocytes":"9.2","Retinal ganglion cells":"3.9","Retinal horizontal cells":"4.0","Rod photoreceptor cells":"3.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"9.1","Fibro-adipogenic progenitors":"7.6","Myocytes":"8.7","Neuronal cells":"6.2","Oocytes":"9.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DXO","Gene synonym":["DOM3Z"],"Ensembl":"ENSG00000204348","Gene description":"Decapping exoribonuclease","Uniprot":["O77932"],"Chromosome":"6","Position":"31969810-31972290","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Exonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Early spermatids":"502.4","Late primary spermatocytes":"176.7","Late spermatids":"342.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"21","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"502.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":15,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA046708":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"}},{"Gene":"DYDC1","Gene synonym":["bA36D19.5","DPY30D1"],"Ensembl":"ENSG00000170788","Gene description":"DPY30 domain containing 1","Uniprot":["Q8WWB3"],"Chromosome":"10","Position":"80336105-80356755","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"testis":"114.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"809.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"809.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"43.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"basophil":"1.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"1.7"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":26,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA037790":null,"HPA037791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"}},{"Gene":"DYDC2","Gene synonym":["bA36D19.6","MGC16186"],"Ensembl":"ENSG00000133665","Gene description":"DPY30 domain containing 2","Uniprot":["Q96IM9"],"Chromosome":"10","Position":"80344745-80368073","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"25.3","fallopian tube":"91.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"51.4","Endometrial ciliated cells":"218.3","Ependymal cells":"82.8","Epididymal efferent duct ciliated cells":"183.8","Fallopian tube ciliated cells":"296.1","Late primary spermatocytes":"81.9","Late spermatids":"49.6","Respiratory ciliated cells":"261.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Ciliated cells":"296.1","Spermatogenic cell types":"81.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"ependymal cell":"132.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"13.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":9,"Subcellular main location":["Vesicles","Principal piece"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA038006":null,"HPA038007":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"}},{"Gene":"DYM","Gene synonym":["DMC","FLJ20071","SMC"],"Ensembl":"ENSG00000141627","Gene description":"Dymeclin","Uniprot":["Q7RTS9"],"Chromosome":"18","Position":"49036387-49461347","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":20,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA043551":null,"HPA049187":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.25e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.11e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.46e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"}},{"Gene":"DYNC2I1","Gene synonym":["CFAP163","DIC6","FAP163","FLJ10300","WDR60"],"Ensembl":"ENSG00000126870","Gene description":"Dynein 2 intermediate chain 1","Uniprot":["Q8WVS4"],"Chromosome":"7","Position":"158856558-158956747","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"575.7","Endometrial ciliated cells":"489.5","Ependymal cells":"695.7","Late primary spermatocytes":"888.4","Respiratory ciliated cells":"501.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"695.7","Spermatogenic cell types":"888.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"7466323.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"4325544.4","ovary":"2076325.4"},"Antibody":["HPA020607","HPA021316"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":28,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Primary cilium","Cytosol"],"Antibody RRID":{"HPA020607":null,"HPA021316":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"}},{"Gene":"DYNC2I2","Gene synonym":["bA216B9.3","CFAP133","DIC5","FAP133","MGC20486","WDR34"],"Ensembl":"ENSG00000119333","Gene description":"Dynein 2 intermediate chain 2","Uniprot":["Q96EX3"],"Chromosome":"9","Position":"128633653-128656847","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"165.9","Enterocytes":"154.5","Fallopian tube ciliated cells":"155.7","Late primary spermatocytes":"156.4","Late spermatids":"367.9","Oocytes":"165.8","Respiratory ciliated cells":"195.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"367.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"37.9","ependymal cell":"40.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"35.9","naive B-cell":"53.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"53.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 17: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":35,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body"],"Subcellular additional location":["Nucleoli","Nuclear bodies","Primary cilium","Cytosol"],"Antibody RRID":{"HPA040764":null,"HPA041091":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.09e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.31e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.97e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.23e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"}},{"Gene":"DYNC2LI1","Gene synonym":["CGI-60","D2LIC","DKFZP564A033","LIC3"],"Ensembl":"ENSG00000138036","Gene description":"Dynein cytoplasmic 2 light intermediate chain 1","Uniprot":["Q8TCX1"],"Chromosome":"2","Position":"43774039-43810010","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Developmental protein","Motor protein"],"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"202.5","Late primary spermatocytes":"330.9","Respiratory ciliated cells":"225.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"330.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"92.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"15.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":15,"Subcellular main location":["Cytosol","Mid piece"],"Subcellular additional location":["Primary cilium","Basal body","Equatorial segment","Perinuclear theca","Principal piece","Annulus"],"Antibody RRID":{"HPA062905":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.48e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"}},{"Gene":"DYNLRB2","Gene synonym":["DNCL2B","DNLC2B","ROBLD2"],"Ensembl":"ENSG00000168589","Gene description":"Dynein light chain roadblock-type 2","Uniprot":["Q8TF09"],"Chromosome":"16","Position":"80540734-80550811","Protein class":["Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"54.7","fallopian tube":"57.1","testis":"157.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"2370.8","Epididymal efferent duct ciliated cells":"768.5","Fallopian tube ciliated cells":"637.5","Late primary spermatocytes":"2421.1","Late spermatids":"1174.1","Respiratory ciliated cells":"729.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Ciliated cells":"768.5","Spermatogenic cell types":"2421.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"313.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"2.7"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1071","Protein cell type specific Intensity":{"Fallopian tube cells":"107149.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"45866","Protein tissue specific Intensity":{"fallopian tube":"4586591.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.81e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"DYNLT2","Gene synonym":["TCTE3","TCTEX1D3","TCTEX2","Tctex4"],"Ensembl":"ENSG00000184786","Gene description":"Dynein light chain Tctex-type 2","Uniprot":["Q8IZS6"],"Chromosome":"6","Position":"169740109-169751587","Protein class":["Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"146","RNA tissue specific nTPM":{"testis":"16.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"144.6","Late primary spermatocytes":"316.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"28","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"316.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"DYNLT2B","Gene synonym":["MGC33212","TCTEX1D2"],"Ensembl":"ENSG00000213123","Gene description":"Dynein light chain Tctex-type 2B","Uniprot":["Q8WW35"],"Chromosome":"3","Position":"196291219-196318299","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Differentiating spermatogonia":"115.9","Early primary spermatocytes":"347.0","Early spermatids":"198.9","Endometrial ciliated cells":"202.4","Epididymal efferent duct ciliated cells":"360.9","Fallopian tube ciliated cells":"423.9","Late primary spermatocytes":"242.4","Respiratory ciliated cells":"338.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"423.9","Spermatogenic cell types":"347.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"29.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"22.0","dendritic cells":"16.2","T-cells":"25.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1541","Protein cell type specific Intensity":{"Fallopian tube cells":"154149.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"8530411.0"},"Antibody":["HPA049555"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Mitotic spindle","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":28,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Mitotic spindle","Basal body","Cytosol"],"Antibody RRID":{"HPA049555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"}},{"Gene":"DYRK3","Gene synonym":["hYAK3-2","RED","REDK"],"Ensembl":"ENSG00000143479","Gene description":"Dual specificity tyrosine phosphorylation regulated kinase 3","Uniprot":["O43781"],"Chromosome":"1","Position":"206635536-206684419","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"44.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"214.0","Erythrocyte progenitors":"91.0","Late primary spermatocytes":"364.5","Salivary basal cells":"89.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"364.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"70.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"2.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland ductal cells","Skeletal muscle - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1075","Protein cell type specific Intensity":{"Skeletal myofibers":"107516.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA075041"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA075041":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.25e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"}},{"Gene":"DYRK4","Gene synonym":[],"Ensembl":"ENSG00000010219","Gene description":"Dual specificity tyrosine phosphorylation regulated kinase 4","Uniprot":["Q9NR20"],"Chromosome":"12","Position":"4562208-4615302","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"34.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"338.6","Late spermatids":"446.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"446.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"12.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028065","HPA056073"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":9,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA028065":null,"HPA056073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"}},{"Gene":"DZANK1","Gene synonym":["ANKRD64","bA189K21.8","C20orf12","C20orf84","dJ568F9.2","FLJ10600","FLJ30892"],"Ensembl":"ENSG00000089091","Gene description":"Double zinc ribbon and ankyrin repeat domains 1","Uniprot":["Q9NVP4"],"Chromosome":"20","Position":"18383367-18467281","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"99.9","Ependymal cells":"226.4","Fallopian tube ciliated cells":"117.4","Respiratory ciliated cells":"195.3","Somatotrophs":"75.7","Thyrotrophs":"106.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"226.4","Pituitary endocrine cells":"106.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"239.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"19.9"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"86569","Protein cell type specific Intensity":{"Fallopian tube cells":"8656889.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"11592","Protein tissue specific Intensity":{"fallopian tube":"889468.3","liver":"1429007.6"},"Antibody":["HPA059478"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059478":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.77e-6"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.85e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"DZIP1","Gene synonym":["DZIP","KIAA0996"],"Ensembl":"ENSG00000134874","Gene description":"DAZ interacting zinc finger protein 1","Uniprot":["Q86YF9"],"Chromosome":"13","Position":"95578202-95644706","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"369.3","Late primary spermatocytes":"525.4","Late spermatids":"1213.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1213.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"20.6"},"RNA tissue cell type enrichment":["Breast - Fibroblasts","Heart muscle - Fibroblasts","Liver - Hepatic stellate cells","Prostate - Fibroblasts","Skeletal muscle - Fibroblasts","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054891","HPA057272"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":7,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA054891":null,"HPA057272":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"E2F2","Gene synonym":["E2F-2"],"Ensembl":"ENSG00000007968","Gene description":"E2F transcription factor 2","Uniprot":["Q14209"],"Chromosome":"1","Position":"23506438-23531233","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Cell cycle","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"23.7","esophagus":"8.3","lymphoid tissue":"14.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"32.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"32.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"2.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"4.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"22.1"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB016313":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.26e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.00e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"}},{"Gene":"E2F7","Gene synonym":[],"Ensembl":"ENSG00000165891","Gene description":"E2F transcription factor 7","Uniprot":["Q96AV8"],"Chromosome":"12","Position":"77021248-77065569","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Cell cycle","DNA damage","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"4.7","lymphoid tissue":"7.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"54.3","Endometrial ciliated cells":"47.6","Ependymal cells":"43.8","Late spermatids":"112.0","Monocyte progenitors":"26.0","Respiratory deuterosomal cells":"64.3","Urothelial cells":"58.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"58.3","Ciliated cells":"64.3","Spermatogenic cell types":"112.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"19","RNA single nuclei brain specific nCPM":{"ependymal cell":"48.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Primary cilium tip","Cytosol"],"Antibody RRID":{"HPA063960":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.02e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.46e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":17,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA064882":null,"HPA076614":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":70,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA059516":null,"HPA060569":null,"HPA069538":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"}},{"Gene":"EAF2","Gene synonym":["BM040","TRAITS","U19"],"Ensembl":"ENSG00000145088","Gene description":"ELL associated factor 2","Uniprot":["Q96CJ1"],"Chromosome":"3","Position":"121835183-121886526","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Transcription","Transcription regulation"],"Molecular function":["Activator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"67.8","lymphoid tissue":"50.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"121.8","Hematopoietic stem cells":"119.9","Megakaryocytes":"185.4","Monocyte progenitors":"131.0","Neutrophil progenitors":"216.4","Plasma cells":"365.5","Prostatic glandular cells":"178.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"216.4","Plasma cells":"365.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"104.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in all","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"Leukemia":"31.8","lymphoma":"51.9","Myeloma":"61.4"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA008411":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - 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Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"3078792.4","lung":"1931211.5"},"Antibody":["HPA021153","HPA021154","CAB072810","CAB072811","CAB072812"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":27,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB072810":null,"CAB072811":null,"CAB072812":null,"HPA021153":null,"HPA021154":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.70e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"}},{"Gene":"EBLN1","Gene synonym":[],"Ensembl":"ENSG00000223601","Gene description":"Endogenous Bornavirus like nucleoprotein 1","Uniprot":["P0CF75"],"Chromosome":"10","Position":"22208475-22218015","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"1.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"15","RNA single cell type specific nCPM":{"Early spermatids":"17.6","Late primary spermatocytes":"23.8","Late spermatids":"12.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"60","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"23.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EBNA1BP2","Gene synonym":["EBP2","NOBP","P40"],"Ensembl":"ENSG00000117395","Gene description":"EBNA1 binding protein 2","Uniprot":["Q99848"],"Chromosome":"1","Position":"43164175-43270936","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatocytes":"396.9","Proximal tubule cells":"388.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"396.9","Renal nephron cells":"388.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in all","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Adrenocortical cancer":"1042.1"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9300","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":74,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Mitotic chromosome"],"Antibody RRID":{"HPA026512":null,"HPA028277":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.91e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"}},{"Gene":"ECRG4","Gene synonym":["augurin","C2orf40"],"Ensembl":"ENSG00000119147","Gene description":"ECRG4 augurin precursor","Uniprot":["Q9H1Z8"],"Chromosome":"2","Position":"106063246-106078155","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"412.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"885.2","Early spermatids":"1213.9","Late primary spermatocytes":"238.8","Late spermatids":"226.9","Pericytes":"418.8","Respiratory ciliated cells":"590.0","Vascular smooth muscle cells":"238.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"590.0","Mural cells":"418.8","Secretory gland support":"885.2","Spermatogenic cell types":"1213.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"314.7","ependymal cell":"101.8"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"12","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"295.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"10","RNA brain regional specific nTPM":{"choroid plexus":"467.0"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"8.5","naive CD8 T-cell":"7.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"83","RNA blood lineage specific nTPM":{"T-cells":"8.5"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Spleen - Fibroblasts_1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008546"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"180000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA008546":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.13e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.90e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"}},{"Gene":"ECT2L","Gene synonym":["ARHGEF32","C6orf91","FBXO49","LFDH"],"Ensembl":"ENSG00000203734","Gene description":"Epithelial cell transforming 2 like","Uniprot":["Q008S8"],"Chromosome":"6","Position":"138795911-138904070","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"fallopian tube":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"971.2","Endometrial ciliated cells":"79.4","Ependymal cells":"226.3","Fallopian tube ciliated cells":"226.5","Respiratory ciliated cells":"568.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"568.6","Myocytes":"971.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"276.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"163212","Protein cell type specific Intensity":{"Fallopian tube cells":"16321239.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"3363893.6"},"Antibody":["HPA035488"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA035488":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EDARADD","Gene synonym":[],"Ensembl":"ENSG00000186197","Gene description":"EDAR associated death domain","Uniprot":["Q8WWZ3"],"Chromosome":"1","Position":"236348257-236502915","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Ectodermal dysplasia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"urinary bladder":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"87.2","Epididymal basal cells":"80.4","Mast cells":"139.0","Pancreatic islet cells":"71.9","Papillary tip epithelial cells":"143.4","Renal collecting duct intercalated cells":"125.4","Respiratory basal cells":"100.7","Syncytiotrophoblasts":"62.2","Urothelial cells":"112.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"112.3","Ductal cells":"125.4","Mast cells":"139.0","Renal nephron cells":"143.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"leukocyte":"22.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"basophil":"49.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"49.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary gland basal cells","Stomach - Parietal cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"51252.9","Pancreatic islets":"105310.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018836"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA018836":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"}},{"Gene":"EDDM13","Gene synonym":[],"Ensembl":"ENSG00000267710","Gene description":"Epididymal protein 13","Uniprot":["A0A1B0GTR0"],"Chromosome":"19","Position":"56272748-56310454","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"142","RNA tissue specific nTPM":{"epididymis":"93.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Epididymal principal cells":"1798.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"1798.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EEF1AKMT2","Gene synonym":["C10orf138","Efm4","METTL10"],"Ensembl":"ENSG00000203791","Gene description":"EEF1A lysine methyltransferase 2","Uniprot":["Q5JPI9"],"Chromosome":"10","Position":"124748149-124791887","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"12.6","Late primary spermatocytes":"35.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"35.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA050138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.02e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"EEF1AKMT4","Gene synonym":[],"Ensembl":"ENSG00000284753","Gene description":"EEF1A lysine methyltransferase 4","Uniprot":["P0DPD7"],"Chromosome":"3","Position":"184249672-184258759","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"3.5","Brain excitatory neurons":"2.4","Brain inhibitory neurons":"2.3","Choroid plexus epithelial cells":"2.3","Early spermatids":"2.6","Late primary spermatocytes":"4.7","Late spermatids":"4.5","Melanocytes":"2.0","Microglia":"2.0","Mucous neck cells":"2.0","Other brain neurons":"4.0","Parietal cells":"1.8","Suprabasal keratinocytes":"5.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"3.5","Neuronal cells":"4.0","Spermatogenic cell types":"4.7","Suprabasal cells":"5.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA062215":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.89e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.94e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.47e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"}},{"Gene":"EEF1E1","Gene synonym":["AIMP3","P18"],"Ensembl":"ENSG00000124802","Gene description":"Eukaryotic translation elongation factor 1 epsilon 1","Uniprot":["O43324"],"Chromosome":"6","Position":"8073360-8102559","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"212.3","Late spermatids":"222.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"222.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"38935175.9"},"Antibody":["HPA027901","HPA057866"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"29000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":23,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA027901":null,"HPA057866":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.97e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.53e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"}},{"Gene":"EEFSEC","Gene synonym":["EFSEC","SELB"],"Ensembl":"ENSG00000132394","Gene description":"Eukaryotic elongation factor, selenocysteine-tRNA specific","Uniprot":["P57772"],"Chromosome":"3","Position":"128153481-128408646","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"51.0","Brain inhibitory neurons":"52.6","Choroid plexus epithelial cells":"89.6","Distal convoluted tubule cells":"60.7","Loop of henle epithelial cells":"52.7","Microglia":"93.0","Oligodendrocyte progenitor cells":"66.9","Other brain neurons":"51.5","Podocytes":"52.4","Proximal tubule cells":"113.6","Renal collecting duct intercalated cells":"65.9","Renal collecting duct principal cells":"49.7","Renal connecting tubule cells":"66.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"89.6","Ductal cells":"66.2","Glial cells":"93.0","Renal nephron cells":"113.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035795"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4200","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.21e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"}},{"Gene":"EFCAB10","Gene synonym":[],"Ensembl":"ENSG00000185055","Gene description":"EF-hand calcium binding domain 10","Uniprot":["A6NFE3"],"Chromosome":"7","Position":"105565120-105600875","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"12.0","fallopian tube":"27.9","testis":"22.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"230.0","Endometrial ciliated cells":"155.1","Ependymal cells":"83.5","Epididymal efferent duct ciliated cells":"100.3","Fallopian tube ciliated cells":"201.7","Late primary spermatocytes":"279.6","Late spermatids":"106.2","Oocytes":"529.6","Respiratory ciliated cells":"236.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"236.3","Oocytes":"529.6","Spermatogenic cell types":"279.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"105.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"13.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"26230","Protein cell type specific Intensity":{"Fallopian tube cells":"2623047.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"21155","Protein tissue specific Intensity":{"fallopian tube":"2115460.4"},"Antibody":["HPA019751"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019751":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"EFCAB11","Gene synonym":["C14orf143"],"Ensembl":"ENSG00000140025","Gene description":"EF-hand calcium binding domain 11","Uniprot":["Q9BUY7"],"Chromosome":"14","Position":"89794669-89954777","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"35.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"486.1","Late primary spermatocytes":"281.8","Late spermatids":"366.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"486.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"2.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"14.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"81","Protein cell type specific Intensity":{"Fallopian tube cells":"8113.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051209"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cell Junctions","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":["Cell Junctions","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA051209":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.32e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"}},{"Gene":"EFCAB12","Gene synonym":["C3orf25"],"Ensembl":"ENSG00000172771","Gene description":"EF-hand calcium binding domain 12","Uniprot":["Q6NXP0"],"Chromosome":"3","Position":"129401321-129428651","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"10.2","fallopian tube":"18.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"51.9","Early spermatids":"40.7","Endometrial ciliated cells":"61.1","Ependymal cells":"130.6","Epididymal efferent duct ciliated cells":"35.3","Fallopian tube ciliated cells":"72.0","Late spermatids":"29.9","Respiratory ciliated cells":"91.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"130.6","Spermatogenic cell types":"40.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"148.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"5.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"1.2"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"11.8"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"18","Protein tissue specific Intensity":{"fallopian tube":"1800.2"},"Antibody":["HPA037694","HPA057532"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Midbody ring"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Midbody ring"],"Antibody RRID":{"HPA037694":null,"HPA057532":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"}},{"Gene":"EFCAB13","Gene synonym":["C17orf57","FLJ40342"],"Ensembl":"ENSG00000178852","Gene description":"EF-hand calcium binding domain 13","Uniprot":["Q8IY85"],"Chromosome":"17","Position":"47323290-47441312","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"19.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"147.6","Cardiomyocytes":"173.6","Early primary spermatocytes":"192.7","Early spermatids":"246.9","Epicardial cells":"347.9","Fibro-adipogenic progenitors":"126.5","Late spermatids":"278.3","Podocytes":"268.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"347.9","Renal nephron cells":"268.9","Spermatogenic cell types":"278.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"125.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"11.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3264","Protein cell type specific Intensity":{"Granulosa cells":"326444.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB002501","HPA021633","HPA023249","HPA026561"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"CAB002501":null,"HPA021633":null,"HPA023249":null,"HPA026561":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.56e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.07e-4"},"Cancer prognostics - 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Gastric mucous cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1718074.9","Distal tubules":"1366565.3","Pancreas epithelial cells":"3284656.9","Pancreatic islets":"2326821.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2801239.9","pancreas":"1235086.0"},"Antibody":["HPA011224","HPA011938"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"70000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":9,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli","Golgi apparatus"],"Antibody RRID":{"HPA011224":null,"HPA011938":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.80e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.89e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.42e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"}},{"Gene":"EFCAB2","Gene synonym":["CFAP200","DRC8","MGC12458"],"Ensembl":"ENSG00000203666","Gene description":"EF-hand calcium binding domain 2","Uniprot":["Q5VUJ9"],"Chromosome":"1","Position":"244969682-245127164","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"564.8","Ependymal cells":"865.0","Fallopian tube ciliated cells":"471.8","Myonuclei":"558.6","Respiratory ciliated cells":"700.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"865.0","Myocytes":"558.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"878.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"5.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol","Mid piece"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA031206":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"EFCAB3","Gene synonym":["FLJ25818"],"Ensembl":"ENSG00000172421","Gene description":"EF-hand calcium binding domain 3","Uniprot":["Q8N7B9"],"Chromosome":"17","Position":"62343941-62416480","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"5.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"139.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"139.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"5.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1577","Protein cell type specific Intensity":{"Pancreatic islets":"157682.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046862"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046862":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.99e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EFCAB5","Gene synonym":["FLJ46247"],"Ensembl":"ENSG00000176927","Gene description":"EF-hand calcium binding domain 5","Uniprot":["A4FU69"],"Chromosome":"17","Position":"29929200-30108452","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"8.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cardiomyocytes":"146.4","Early primary spermatocytes":"61.8","Early spermatids":"201.3","Late primary spermatocytes":"207.1","Late spermatids":"167.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Myocytes":"146.4","Spermatogenic cell types":"207.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"2.4","eosinophil":"3.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA022852":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EFCAB6","Gene synonym":["dJ185D5.1","DJBP","FLJ23588","HSCBCIP1","KIAA1672"],"Ensembl":"ENSG00000186976","Gene description":"EF-hand calcium binding domain 6","Uniprot":["Q5THR3"],"Chromosome":"22","Position":"43528744-43812337","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"fallopian tube":"7.2","testis":"22.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"305.6","Early spermatids":"473.2","Endometrial ciliated cells":"226.3","Ependymal cells":"733.1","Fallopian tube ciliated cells":"223.7","Late spermatids":"802.6","Respiratory ciliated cells":"516.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"733.1","Spermatogenic cell types":"802.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"239.0","ependymal cell":"804.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA003098":null,"HPA018946":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EFCAB7","Gene synonym":["KIAA1799","RP4-534K7.1"],"Ensembl":"ENSG00000203965","Gene description":"EF-hand calcium binding domain 7","Uniprot":["A8K855"],"Chromosome":"1","Position":"63523372-63572693","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"92.2","Late primary spermatocytes":"138.8","Thymic myoid cells":"239.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"138.8","Stromal cells":"239.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"10.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":2,"Subcellular main location":["Primary cilium","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA029611":null,"HPA029612":null,"HPA029613":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.32e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"}},{"Gene":"EFCAB8","Gene synonym":[],"Ensembl":"ENSG00000215529","Gene description":"EF-hand calcium binding domain 8","Uniprot":["A8MWE9"],"Chromosome":"20","Position":"32858923-32961845","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"3.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"11.3","Epididymal clear cells":"8.2","Innate lymphoid cells":"12.2","Late primary spermatocytes":"18.2","Neutrophils":"18.0","Pancreatic islet cells":"8.4","Pituitary stem cells":"15.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"18.0","Spermatogenic cell types":"18.2","Stem cells":"15.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB034246":null,"HPA042751":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear bodies","Vesicles","Connecting piece"],"Antibody RRID":{"HPA034835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"}},{"Gene":"EFHC1","Gene synonym":["EJM","EJM1","FLJ10466","POC9","RIB72"],"Ensembl":"ENSG00000096093","Gene description":"EF-hand domain containing 1","Uniprot":["Q5JVL4"],"Chromosome":"6","Position":"52362123-52529886","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"32.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"352.3","Endometrial ciliated cells":"432.2","Ependymal cells":"456.8","Epididymal efferent duct ciliated cells":"481.4","Fallopian tube ciliated cells":"483.2","Respiratory ciliated cells":"663.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"663.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"353.8","ependymal cell":"505.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"6.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":64,"Subcellular main location":["Plasma membrane","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Cytosol","Equatorial segment"],"Antibody RRID":{"HPA035307":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":85,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034492":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"EFL1","Gene synonym":["EFTUD1","FAM42A","FLJ13119","HsT19294","RIA1"],"Ensembl":"ENSG00000140598","Gene description":"Elongation factor like GTPase 1","Uniprot":["Q7Z2Z2"],"Chromosome":"15","Position":"82130206-82262773","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis","Ribosome biogenesis"],"Molecular function":["Elongation factor","Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"10952617.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"4708674.3"},"Antibody":["HPA039654","HPA047110","HPA052345"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"14000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039654":null,"HPA047110":null,"HPA052345":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.86e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-3"}},{"Gene":"EFNB3","Gene synonym":["EPLG8","LERK-8"],"Ensembl":"ENSG00000108947","Gene description":"Ephrin B3","Uniprot":["Q15768"],"Chromosome":"17","Position":"7705202-7711372","Protein class":["Cancer-related genes","Predicted membrane proteins"],"Biological process":["Differentiation","Host-virus interaction","Neurogenesis"],"Molecular function":["Developmental protein","Host cell receptor for virus entry","Receptor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"41.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"11.9","Brain inhibitory neurons":"19.1","Early spermatids":"9.4","Ependymal cells":"22.0","Epididymal efferent duct ciliated cells":"17.2","Hepatic stellate cells":"12.9","Other brain neurons":"21.6","Pancreatic islet cells":"10.0","Respiratory ciliated cells":"24.4","Retinal amacrine cells":"8.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"24.4","Neuronal cells":"21.6","Stellate cells":"12.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"25.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"17.5"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Colon enteroendocrine cells","Liver - Hepatic stellate cells","Lung - Respiratory ciliated cells","Prostate - Prostate basal glandular cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1456869.1","Microglia and Neuropil":"2081206.7","Neurons":"734390.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2263591.5"},"Antibody":["HPA001623"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5600","Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA001623":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"}},{"Gene":"EGF","Gene synonym":[],"Ensembl":"ENSG00000138798","Gene description":"Epidermal growth factor","Uniprot":["P01133"],"Chromosome":"4","Position":"109912883-110013766","Protein class":["Cancer-related genes","Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted membrane proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets","Primary hypomagnesemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"kidney":"102.9","pancreas":"84.4","skeletal muscle":"26.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"4773.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Renal nephron cells":"4773.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"46.4","lower rhombic lip":"44.0"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"27.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary glandular cells","Pancreas - Exocrine glandular cells","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"7630368.7","Pancreas epithelial cells":"3293515.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"389","Protein tissue specific Intensity":{"kidney":"38908.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"980000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.39e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EGLN2","Gene synonym":["HIFPH1","PHD1"],"Ensembl":"ENSG00000269858","Gene description":"Egl-9 family hypoxia inducible factor 2","Uniprot":["Q96KS0"],"Chromosome":"19","Position":"40798996-40808434","Protein class":["Enzymes","FDA approved drug targets","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"223.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1.0","Late primary spermatocytes":"2.1","Platelets":"2.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"2.8","Spermatogenic cell types":"2.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA056649":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"EHBP1","Gene synonym":["KIAA0903","NACSIN"],"Ensembl":"ENSG00000115504","Gene description":"EH domain binding protein 1","Uniprot":["Q8NDI1"],"Chromosome":"2","Position":"62673851-63046487","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Endocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"1746.1","Schwann cells":"1537.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"1746.1","Glial cells":"1537.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"3925622.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"56836078.1"},"Antibody":["HPA035468","HPA035469"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":5,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035468":null,"HPA035469":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.95e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"}},{"Gene":"EID3","Gene synonym":["FLJ25832","NSE4B","NSMCE4B"],"Ensembl":"ENSG00000255150","Gene description":"EP300 interacting inhibitor of differentiation 3","Uniprot":["Q8N140"],"Chromosome":"12","Position":"104303739-104305205","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"57.2"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"8.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"11.7"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059367"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":20,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA059367":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"}},{"Gene":"EIF2B2","Gene synonym":["EIF-2Bbeta","EIF2B","EIF2Bbeta"],"Ensembl":"ENSG00000119718","Gene description":"Eukaryotic translation initiation factor 2B subunit beta","Uniprot":["P49770"],"Chromosome":"14","Position":"75002921-75012366","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"111.8","Syncytiotrophoblasts":"245.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"111.8","Trophoblast cells":"245.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"4434438.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005841","CAB037105","HPA048028"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Focal adhesion sites"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":41,"Subcellular main location":["Plasma membrane","Focal adhesion sites"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB037105":null,"HPA005841":null,"HPA048028":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"}},{"Gene":"EIF2B3","Gene synonym":["EIF-2B","EIF2Bgamma"],"Ensembl":"ENSG00000070785","Gene description":"Eukaryotic translation initiation factor 2B subunit gamma","Uniprot":["Q9NR50"],"Chromosome":"1","Position":"44850522-44986722","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"444.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"444.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024213","HPA024218","HPA024219"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5900","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":32,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA024213":null,"HPA024218":null,"HPA024219":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.16e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.74e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"EIF2B4","Gene synonym":["DKFZP586J0119","EIF-2B","EIF2B","EIF2Bdelta"],"Ensembl":"ENSG00000115211","Gene description":"Eukaryotic translation initiation factor 2B subunit delta","Uniprot":["Q9UI10"],"Chromosome":"2","Position":"27364352-27370338","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":["Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"223.8","Esophageal apical cells":"110.9","Late primary spermatocytes":"126.2","Late spermatids":"419.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"110.9","Spermatogenic cell types":"419.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Skin - Hair cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"35020295.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB032234","HPA068855"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":22,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB032234":null,"HPA068855":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.61e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"}},{"Gene":"EIF2D","Gene synonym":["LGTN"],"Ensembl":"ENSG00000143486","Gene description":"Eukaryotic translation initiation factor 2D","Uniprot":["P41214"],"Chromosome":"1","Position":"206571292-206612465","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028220"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA028220":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"}},{"Gene":"EIF2S2","Gene synonym":["EIF2","EIF2beta","PPP1R67"],"Ensembl":"ENSG00000125977","Gene description":"Eukaryotic translation initiation factor 2 subunit beta","Uniprot":["P20042"],"Chromosome":"20","Position":"34088309-34112243","Protein class":["Cancer-related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"682.7","Syncytiotrophoblasts":"691.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB034415","HPA041262","HPA041332","HPA065768"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"190000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":71,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB034415":null,"HPA041262":null,"HPA041332":null,"HPA065768":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.96e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.58e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.33e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"}},{"Gene":"EIF2S3B","Gene synonym":["eIF-2-gamma2","eIF2gA"],"Ensembl":"ENSG00000180574","Gene description":"Eukaryotic translation initiation factor 2 subunit gamma B","Uniprot":["Q2VIR3"],"Chromosome":"12","Position":"10505602-10523135","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Hydrolase","Initiation factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"7.1","Early primary spermatocytes":"13.8","Early spermatids":"8.6","Goblet cells":"12.1","Hepatic stellate cells":"6.5","Late primary spermatocytes":"9.5","Undifferentiated spermatogonia":"8.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Goblet cells":"12.1","Spermatogenic cell types":"13.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"120000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":123,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049250":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"42000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":139,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041997":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.53e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"}},{"Gene":"EIF3H","Gene synonym":["eIF3-gamma","eIF3-p40","EIF3S3"],"Ensembl":"ENSG00000147677","Gene description":"Eukaryotic translation initiation factor 3 subunit H","Uniprot":["O15372"],"Chromosome":"8","Position":"116642130-116766925","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1458.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1458.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"72000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":119,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA023117":null,"HPA023553":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.29e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.23e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-3"}},{"Gene":"EIF4E","Gene synonym":["EIF4E1","EIF4EL1","EIF4F"],"Ensembl":"ENSG00000151247","Gene description":"Eukaryotic translation initiation factor 4E","Uniprot":["P06730"],"Chromosome":"4","Position":"98879276-98929133","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","mRNA transport","Protein biosynthesis","Translation regulation","Transport"],"Molecular function":["Initiation factor","RNA-binding"],"Disease involvement":["Autism","Autism spectrum disorder","Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"320.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004077","CAB016316","HPA068358"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol","Cytoplasmic bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"160000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":102,"Subcellular main location":["Cytosol","Cytoplasmic bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB004077":null,"CAB016316":null,"HPA068358":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.29e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"}},{"Gene":"EIF4E2","Gene synonym":["4EHP","EIF4EL3","IF4e"],"Ensembl":"ENSG00000135930","Gene description":"Eukaryotic translation initiation factor 4E family member 2","Uniprot":["O60573"],"Chromosome":"2","Position":"232550659-232583644","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis","RNA-mediated gene silencing","Translation regulation"],"Molecular function":["Initiation factor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"277.5","Late spermatids":"489.4","Myonuclei":"253.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"489.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019253","HPA077074"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":73,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA019253":null,"HPA077074":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.59e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"}},{"Gene":"EIF4EBP3","Gene synonym":["4E-BP3"],"Ensembl":"ENSG00000243056","Gene description":"Eukaryotic translation initiation factor 4E binding protein 3","Uniprot":["O60516"],"Chromosome":"5","Position":"140547662-140549576","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Translation regulation"],"Molecular function":["Protein synthesis inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"17.0","Enteric stem cells":"23.6","Enteric transient amplifying cells":"15.8","Enterocytes":"34.0","Epididymal clear cells":"36.7","Epididymal efferent duct absorptive cells":"36.1","Epididymal efferent duct ciliated cells":"21.0","Fallopian tube ciliated cells":"14.9","Foveolar cells":"14.3","Gastric chief cells":"29.5","Mucous neck cells":"15.6","Paneth cells":"19.3","Parietal cells":"38.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"36.1","Enterocytes":"34.0","Gastric glandular cells":"38.9","Reproductive supporting cells":"36.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"38.6"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045537"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045537":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"}},{"Gene":"EIF4ENIF1","Gene synonym":["2610509L04Rik","4E-T","Clast4","FLJ21601"],"Ensembl":"ENSG00000184708","Gene description":"Eukaryotic translation initiation factor 4E nuclear import factor 1","Uniprot":["Q9NRA8"],"Chromosome":"22","Position":"31436977-31496108","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Protein transport","RNA-mediated gene silencing","Translation regulation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"156.1","Oocytes":"128.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"156.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":46,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001619":null,"HPA002078":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.63e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.36e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"EIF4G3","Gene synonym":["eIF4GII"],"Ensembl":"ENSG00000075151","Gene description":"Eukaryotic translation initiation factor 4 gamma 3","Uniprot":["O43432"],"Chromosome":"1","Position":"20806292-21177285","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis","Translation regulation"],"Molecular function":["Initiation factor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"2146.1","Neutrophil progenitors":"1639.9","Neutrophils":"1801.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2146.1","Neutrophils":"1801.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"73262548.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"3661109.4"},"Antibody":["HPA025031","HPA025039","HPA025041"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"60000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":34,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA025031":null,"HPA025039":null,"HPA025041":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.31e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"EIF5A2","Gene synonym":[],"Ensembl":"ENSG00000163577","Gene description":"Eukaryotic translation initiation factor 5A2","Uniprot":["Q9GZV4"],"Chromosome":"3","Position":"170888418-170908644","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Protein biosynthesis"],"Molecular function":["Elongation factor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"26.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"379.9","Late primary spermatocytes":"187.0","Late spermatids":"1292.1","Parietal cells":"242.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1292.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Liver - Vascular endothelial cells","Skeletal muscle - Endothelial cells","Stomach - Parietal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029090"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":14,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA029090":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.85e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"}},{"Gene":"EIF5AL1","Gene synonym":["bA342M3.3","EIF5AP1"],"Ensembl":"ENSG00000253626","Gene description":"Eukaryotic translation initiation factor 5A like 1","Uniprot":["Q6IS14"],"Chromosome":"10","Position":"79512533-79516440","Protein class":["Essential proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Protein biosynthesis"],"Molecular function":["Elongation factor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"9.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"35.6","Enteric stem cells":"36.1","Enteric transient amplifying cells":"44.6","Esophageal basal cells":"34.1","Esophageal suprabasal cells":"27.2","Foveolar cells":"26.4","Goblet cells":"35.6","Late primary spermatocytes":"62.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"44.6","Spermatogenic cell types":"62.2"},"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA074052"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 17: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA074052":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"}},{"Gene":"EIF6","Gene synonym":["b(2)gcn","EIF3A","ITGB4BP","p27BBP"],"Ensembl":"ENSG00000242372","Gene description":"Eukaryotic translation initiation factor 6","Uniprot":["P56537"],"Chromosome":"20","Position":"35278907-35284985","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis","Ribosome biogenesis"],"Molecular function":["Initiation factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"184.9","Esophageal apical cells":"314.0","Esophageal suprabasal cells":"203.5","Gastric progenitor cells":"191.0","Suprabasal keratinocytes":"258.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"314.0","Suprabasal cells":"258.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040873"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"650000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":53,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA040873":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.21e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.14e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.72e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"}},{"Gene":"EIPR1","Gene synonym":["EIPR-1","TSSC1"],"Ensembl":"ENSG00000032389","Gene description":"EARP complex and GARP complex interacting protein 1","Uniprot":["Q53HC9"],"Chromosome":"2","Position":"3188925-3377830","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":37,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Intermediate filaments"],"Antibody RRID":{"HPA031231":null,"HPA031232":null,"HPA031233":null,"HPA031234":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.08e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"}},{"Gene":"ELAPOR1","Gene synonym":["EIG121","KIAA1324","maba1"],"Ensembl":"ENSG00000116299","Gene description":"Endosome-lysosome associated apoptosis and autophagy regulator 1","Uniprot":["Q6UXG2"],"Chromosome":"1","Position":"109113679-109206781","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"147.7","salivary gland":"156.2","stomach 1":"83.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"466.9","Goblet cells":"332.0","Gonadotrophs":"313.6","Lacrimal acinar cells":"485.5","Lactotrophs":"452.9","Mucous neck cells":"297.6","Pancreatic islet cells":"392.9","Paneth cells":"506.6","Prostatic glandular cells":"738.4","Salivary acinar cells":"524.0","Somatotrophs":"379.1","Thyrotrophs":"360.2","Tuft cells":"299.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"524.0","Glandular cells":"738.4","Pituitary endocrine cells":"466.9","Secretory gland support":"506.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"79.6","Prostate Adenocarcinoma (TCGA)":"78.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"neutrophil":"65.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"65.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"34.8"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Colon enterocytes","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"57665951.4","Pancreatic islets":"90205519.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"17408524.0","pancreas":"53835646.8","salivary gland":"26598431.7"},"Antibody":["HPA029869","HPA070749"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA029869":null,"HPA070749":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.59e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.10e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"}},{"Gene":"ELAPOR2","Gene synonym":["EIG121L","FLJ31340","KIAA1324L"],"Ensembl":"ENSG00000164659","Gene description":"Endosome-lysosome associated apoptosis and autophagy regulator family member 2","Uniprot":["A8MWY0"],"Chromosome":"7","Position":"86876906-87059654","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lung":"20.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"298.1","Corticotrophs":"217.9","Lactotrophs":"240.1","Late spermatids":"147.9","Oligodendrocytes":"362.8","Somatotrophs":"159.6","Thyrotrophs":"164.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"298.1","Glial cells":"362.8","Pituitary endocrine cells":"240.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"511.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"1.9","NK-cells":"2.3","T-cells":"2.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"2866887.8","Astrocytes and Neuropil":"3519033.8","Microglia and Neuropil":"1327399.5","Neurons":"4089560.8","Oocytes":"1131610.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"246008.5","lung":"219271.2"},"Antibody":["HPA044527","HPA076093"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":3,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA044527":null,"HPA076093":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":197,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"CAB005256":null,"HPA046298":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":2,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB004442":null,"HPA043047":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ELF2","Gene synonym":["EU32","NERF","NERF-1A","NERF-1B","NERF-2"],"Ensembl":"ENSG00000109381","Gene description":"E74 like ETS transcription factor 2","Uniprot":["Q15723"],"Chromosome":"4","Position":"139028112-139177218","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Neutrophils":"4633.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neutrophils":"4633.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA006057":null,"HPA071166":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.79e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA000781":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.31e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ELL3","Gene synonym":["FLJ22637"],"Ensembl":"ENSG00000128886","Gene description":"Elongation factor for RNA polymerase II 3","Uniprot":["Q9HB65"],"Chromosome":"15","Position":"43772605-43777315","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"54.0","skin 1":"25.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"6.9","Colonocytes":"1.3","Enteric stem cells":"1.0","Enteric transient amplifying cells":"1.8","Enterocytes":"2.7","Ependymal cells":"1.2","Goblet cells":"1.2","Parietal cells":"1.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"6.9","Enterocytes":"2.7","Gastric glandular cells":"1.8","Proliferating cells":"1.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"10.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"8","RNA brain regional specific nTPM":{"choroid plexus":"11.0"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"11.2","naive B-cell":"17.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"17.0"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"lymphoma":"72.9"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":11,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Mitotic chromosome"],"Antibody RRID":{"HPA028938":null,"HPA073494":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"ELMO3","Gene synonym":["CED-12","CED12","ELMO-3","FLJ13824"],"Ensembl":"ENSG00000102890","Gene description":"Engulfment and cell motility 3","Uniprot":["Q96BJ8"],"Chromosome":"16","Position":"67199111-67204029","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Phagocytosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"97.3","Colonocytes":"63.7","Enteric transient amplifying cells":"46.9","Enterocytes":"87.9","Foveolar cells":"45.6","Late spermatids":"67.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"87.9","Secretory cells":"97.3","Spermatogenic cell types":"67.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"7.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA021484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 55: Breast - Lactation","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":61,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA005910":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.67e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"51000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":112,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoli","Cell Junctions"],"Antibody RRID":{"HPA078113":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045606":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.88e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"}},{"Gene":"ELP5","Gene synonym":["C17orf81","DERP6"],"Ensembl":"ENSG00000170291","Gene description":"Elongator acetyltransferase complex subunit 5","Uniprot":["Q8TE02"],"Chromosome":"17","Position":"7251416-7259940","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"160.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"188.8","Late primary spermatocytes":"284.8","Late spermatids":"742.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"742.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023279":null,"HPA052411":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":47,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042372":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":32,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA062681":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":67,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010029":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"EMC8","Gene synonym":["C16orf2","C16orf4","COX4NB","FAM158B","NOC4"],"Ensembl":"ENSG00000131148","Gene description":"ER membrane protein complex subunit 8","Uniprot":["O43402"],"Chromosome":"16","Position":"85771758-85799608","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"248.1","Late primary spermatocytes":"187.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"248.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049476"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":90,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA049476":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"}},{"Gene":"EME1","Gene synonym":["FLJ31364","MMS4L","SLX2A"],"Ensembl":"ENSG00000154920","Gene description":"Essential meiotic structure-specific endonuclease 1","Uniprot":["Q96AY2"],"Chromosome":"17","Position":"50373220-50381483","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"4.1","epididymis":"6.0","testis":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"17.0","Early primary spermatocytes":"16.0","Epicardial cells":"31.8","Epididymal principal cells":"63.9","Megakaryocyte progenitors":"11.2","Megakaryocytes":"12.4","Oocytes":"9.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"31.8","Reproductive supporting cells":"63.9","Spermatogenic cell types":"17.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"34","RNA blood cell specific nTPM":{"basophil":"18.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"34","RNA blood lineage specific nTPM":{"granulocytes":"18.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Kidney - Fibroblasts","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB016127","HPA021202","HPA023854"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB016127":null,"HPA021202":null,"HPA023854":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.16e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.91e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.24e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.88e-6"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"}},{"Gene":"EML6","Gene synonym":["FLJ42562"],"Ensembl":"ENSG00000214595","Gene description":"EMAP like 6","Uniprot":["Q6ZMW3"],"Chromosome":"2","Position":"54723499-54972025","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"8.9","retina":"11.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"193.3","Brain excitatory neurons":"283.8","Brain inhibitory neurons":"258.7","Ependymal cells":"371.0","Gonadotrophs":"187.4","Lactotrophs":"175.7","Other brain neurons":"219.0","Retinal bipolar cells":"171.7","Retinal horizontal cells":"246.4","Rod photoreceptor cells":"194.2","Somatotrophs":"183.8","Thyrotrophs":"192.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"371.0","Glial cells":"193.3","Neuronal cells":"283.8","Pituitary endocrine cells":"192.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"9.7","Neuroblastoma":"7.2"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA062808":null,"HPA068759":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.26e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":11,"Subcellular main location":["Mid piece"],"Subcellular additional location":["Cytosol","Principal piece"],"Antibody RRID":{"HPA037593":null,"HPA037594":null,"HPA061503":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037938":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"}},{"Gene":"ENOX1","Gene synonym":["cCNOX","CNOX","FLJ10094","PIG38"],"Ensembl":"ENSG00000120658","Gene description":"Ecto-NOX disulfide-thiol exchanger 1","Uniprot":["Q8TC92"],"Chromosome":"13","Position":"43213130-43786972","Protein class":["Predicted intracellular proteins"],"Biological process":["Biological rhythms","Electron transport","Transport"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"470.5","Brain inhibitory neurons":"519.6","Cardiomyocytes":"333.9","Early spermatids":"357.7","Late spermatids":"418.0","Loop of henle epithelial cells":"338.1","Medullary thymic epithelial cells":"420.0","Oligodendrocytes":"793.2","Other brain neurons":"300.6","Retinal amacrine cells":"550.5","Retinal ganglion cells":"378.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"793.2","Neuronal cells":"550.5","Secretory gland support":"420.0","Spermatogenic cell types":"418.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"13.8"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":6,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA038355":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":null,"Subcellular main location":["Nucleoli rim"],"Subcellular additional location":null,"Antibody RRID":{"HPA042466":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":31,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029303":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.58e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA006659":null,"HPA050674":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.49e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"}},{"Gene":"EPB41L3","Gene synonym":["4.1B","DAL1","KIAA0987"],"Ensembl":"ENSG00000082397","Gene description":"Erythrocyte membrane protein band 4.1 like 3","Uniprot":["Q9Y2J2"],"Chromosome":"18","Position":"5392381-5630700","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Apoptosis"],"Molecular function":["Actin-binding"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"461.6","Enterocytes":"471.9","Esophageal apical cells":"440.7","Kupffer cells":"452.0","Late spermatids":"459.7","Macrophages":"479.3","monocytes":"600.8","Proximal tubule cells":"557.9","Retinal amacrine cells":"527.1","Retinal ganglion cells":"591.0","Sertoli cells":"461.0","Syncytiotrophoblasts":"542.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"600.8","Neuronal cells":"591.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"7.7","non-classical monocyte":"12.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"monocytes":"12.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"380000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":59,"Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":["Primary cilium","Basal body"],"Antibody RRID":{"HPA028605":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.61e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":1,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA014420":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.55e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA027497":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EPHA5","Gene synonym":["CEK7","EHK1","Hek7","TYRO4"],"Ensembl":"ENSG00000145242","Gene description":"EPH receptor A5","Uniprot":["P54756"],"Chromosome":"4","Position":"65319563-65670495","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Neurogenesis"],"Molecular function":["Kinase","Receptor","Transferase","Tyrosine-protein kinase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"10.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"106.4","Brain excitatory neurons":"296.3","Brain inhibitory neurons":"137.5","Lactotrophs":"275.0","Melanocytes":"120.9","Oligodendrocyte progenitor cells":"111.6","Other brain neurons":"205.9","Prostatic glandular cells":"290.2","Retinal amacrine cells":"100.2","Retinal ganglion cells":"258.8","Somatotrophs":"134.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"290.2","Glial cells":"111.6","Neuronal cells":"296.3","Pigment cells":"120.9","Pituitary endocrine cells":"275.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"930.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.7","Prostate Adenocarcinoma (TCGA)":"1.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"10.7","Sarcoma":"21.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"98000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":13,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"HPA034528":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EPHA6","Gene synonym":["FLJ35246"],"Ensembl":"ENSG00000080224","Gene description":"EPH receptor A6","Uniprot":["Q9UF33"],"Chromosome":"3","Position":"96814581-97761532","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Receptor","Transferase","Tyrosine-protein kinase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"3.8","testis":"7.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Astrocytes":"312.0","Brain excitatory neurons":"909.0","Brain inhibitory neurons":"983.4","Early spermatids":"481.9","Gonadotrophs":"309.6","Late primary spermatocytes":"392.9","Late spermatids":"463.7","Other brain neurons":"709.8","Retinal amacrine cells":"382.3","Retinal ganglion cells":"668.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"312.0","Neuronal cells":"983.4","Pituitary endocrine cells":"309.6","Spermatogenic cell types":"481.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"3566.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"2.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"11.1","prostate cancer":"7.6","Rhabdoid":"7.2"},"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"36000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":10,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA007397":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EPM2A","Gene synonym":["LD","LDE"],"Ensembl":"ENSG00000112425","Gene description":"EPM2A glucan phosphatase, laforin","Uniprot":["O95278"],"Chromosome":"6","Position":"145382535-145736023","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Autophagy","Carbohydrate metabolism","Glycogen metabolism"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Disease variant","Epilepsy","Glycogen storage disease","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"71.9","tongue":"74.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"147.6","Myonuclei":"294.0","Retinal horizontal cells":"238.4","Tuft cells":"760.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"294.0","Neuronal cells":"238.4","Secretory gland support":"760.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"2.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA053643":null,"HPA055468":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.46e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.13e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.02e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"}},{"Gene":"EPPK1","Gene synonym":["EPIPL1"],"Ensembl":"ENSG00000261150","Gene description":"Epiplakin 1","Uniprot":["P58107"],"Chromosome":"8","Position":"143857324-143878467","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skin 1":"15.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"83.9","Basal keratinocytes":"124.4","Gastric progenitor cells":"70.5","Ocular epithelial cells":"101.2","Suprabasal keratinocytes":"207.3","Urothelial cells":"48.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"83.9","Barrier epithelial cells":"101.2","Basal cells":"124.4","Suprabasal cells":"207.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"31.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"27.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 9: Skin - Hair follicle development","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":23,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA066808":null,"HPA067357":null,"HPA069333":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"}},{"Gene":"EQTN","Gene synonym":["AFAF","C9orf11","equatorin","SPACA8"],"Ensembl":"ENSG00000120160","Gene description":"Equatorin","Uniprot":["Q9NQ60"],"Chromosome":"9","Position":"27284654-27297150","Protein class":["Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"52","RNA tissue specific nTPM":{"testis":"35.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"18","RNA single cell type specific nCPM":{"Early spermatids":"757.8","Late primary spermatocytes":"553.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"196","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"757.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"5.1","oligodendrocyte":"5.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Plasma membrane","Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA015089":null,"HPA015504":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ERCC4","Gene synonym":["FANCQ","RAD1","XPF"],"Ensembl":"ENSG00000175595","Gene description":"ERCC excision repair 4, endonuclease catalytic subunit","Uniprot":["Q92889"],"Chromosome":"16","Position":"13920138-13952348","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding","Endonuclease","Hydrolase","Nuclease"],"Disease involvement":["Cancer-related genes","Cockayne syndrome","Disease variant","Dwarfism","Fanconi anemia","Xeroderma pigmentosum"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"17.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"264.6","Late spermatids":"220.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"264.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":27,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB000156":null,"HPA045828":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.59e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"}},{"Gene":"ERCC5","Gene synonym":["ERCM2","XPGC"],"Ensembl":"ENSG00000134899","Gene description":"ERCC excision repair 5, endonuclease","Uniprot":["P28715"],"Chromosome":"13","Position":"102845831-102875995","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding","Endonuclease","Hydrolase","Nuclease"],"Disease involvement":["Cancer-related genes","Cockayne syndrome","Deafness","Disease variant","Dwarfism","Xeroderma pigmentosum"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Astrocytes":"25.7","Bergmann glia":"39.3","Brain excitatory neurons":"42.7","Brain inhibitory neurons":"44.2","Choroid plexus epithelial cells":"35.6","Ependymal cells":"15.8","Microglia":"49.0","Oligodendrocyte progenitor cells":"34.1","Oligodendrocytes":"45.0","Other brain neurons":"35.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"35.6","Glial cells":"49.0","Neuronal cells":"44.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA045845":null,"HPA050374":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.22e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"120467.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029328"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":35,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA029328":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"ERFE","Gene synonym":["C1QTNF15","CTRP15","FAM132B","FLJ37034"],"Ensembl":"ENSG00000178752","Gene description":"Erythroferrone","Uniprot":["Q4G0M1"],"Chromosome":"2","Position":"238158970-238168900","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"14.1","testis":"12.4","thyroid gland":"23.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"52.0","Late primary spermatocytes":"67.9","Myosatellite cells":"25.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"67.9","Stem cells":"25.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"6.8","miscellaneous":"2.9","upper rhombic lip":"3.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"31.9","Thyroid Carcinoma (TCGA)":"49.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Uterine cancer":"25.9"},"RNA tissue cell type enrichment":["Breast - Endothelial cells","Spleen - Erythrocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1601","Protein cell type specific Intensity":{"Oocytes":"160127.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Hormone","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":277000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.43e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.34e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.74e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.12e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"}},{"Gene":"ERGIC2","Gene synonym":["Erv41","PTX1"],"Ensembl":"ENSG00000087502","Gene description":"ERGIC and golgi 2","Uniprot":["Q96RQ1"],"Chromosome":"12","Position":"29337352-29381189","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["ER-Golgi transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"393.0","Late primary spermatocytes":"282.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"393.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":38,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":["Nucleoli rim"],"Antibody RRID":{"HPA049695":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-3"},"Cancer prognostics - 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Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"22902288.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015242","HPA015968"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":205,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015242":null,"HPA015968":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.44e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.19e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"}},{"Gene":"ERI1","Gene synonym":["3'HEXO","THEX1"],"Ensembl":"ENSG00000104626","Gene description":"Exoribonuclease 1","Uniprot":["Q8IV48"],"Chromosome":"8","Position":"9002147-9116746","Protein class":["Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing","rRNA processing"],"Molecular function":["Exonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":["Disease variant","Dwarfism","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"34.0","Ependymal cells":"31.1","Microglia":"28.8","Neutrophils":"30.7","Renal collecting duct principal cells":"30.1","Rod photoreceptor cells":"29.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":11,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB033838":null,"HPA055548":null,"HPA056074":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.89e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"}},{"Gene":"ERI3","Gene synonym":["FLJ22943","PINT1","PRNPIP"],"Ensembl":"ENSG00000117419","Gene description":"ERI1 exoribonuclease family member 3","Uniprot":["O43414"],"Chromosome":"1","Position":"44221070-44355260","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Exonuclease","Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"1634.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1634.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"12140573.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"6778563.0"},"Antibody":["HPA027147","HPA029895"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA027147":null,"HPA029895":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.15e-5"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.50e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.94e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"}},{"Gene":"ERICH2","Gene synonym":[],"Ensembl":"ENSG00000204334","Gene description":"Glutamate rich 2","Uniprot":["A1L162"],"Chromosome":"2","Position":"170766878-170798977","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"choroid plexus":"45.3","testis":"155.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"2878.1","Late primary spermatocytes":"1068.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"21","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2878.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"33.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"olfactory bulb":"33.6"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA061010"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":4,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA061010":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.51e-7"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.41e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.70e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"}},{"Gene":"ERICH3","Gene synonym":["C1orf173","DKFZp547I048","RP11-653A5.1"],"Ensembl":"ENSG00000178965","Gene description":"Glutamate rich 3","Uniprot":["Q5RHP9"],"Chromosome":"1","Position":"74568117-74673792","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"10.4","fallopian tube":"16.3","testis":"22.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"320.0","Endometrial ciliated cells":"283.1","Ependymal cells":"236.5","Epididymal efferent duct ciliated cells":"296.7","Fallopian tube ciliated cells":"554.7","Lactotrophs":"141.6","Late primary spermatocytes":"252.8","Late spermatids":"532.9","Respiratory ciliated cells":"984.9","Thyrotrophs":"140.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"984.9","Spermatogenic cell types":"532.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Rhabdoid":"4.0"},"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Liver - Hepatocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"83646336.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"124221159.1"},"Antibody":["HPA028655","HPA072916"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nuclear membrane","Nucleoli","Endoplasmic reticulum","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nuclear membrane","Endoplasmic reticulum"],"Subcellular additional location":["Nucleoli","Primary cilium"],"Antibody RRID":{"HPA028655":null,"HPA072916":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"}},{"Gene":"ERICH4","Gene synonym":["C19orf69","LOC100170765"],"Ensembl":"ENSG00000204978","Gene description":"Glutamate rich 4","Uniprot":["A6NGS2"],"Chromosome":"19","Position":"41443156-41444765","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"intestine":"40.0","kidney":"15.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"14","RNA single cell type specific nCPM":{"Enterocytes":"190.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Enterocytes":"190.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"31","RNA single nuclei brain specific nCPM":{"endothelial cell":"5.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Minor Salivary Gland - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"174803.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2425","Protein tissue specific Intensity":{"kidney":"242456.3"},"Antibody":["HPA042632","HPA048484"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA042632":null,"HPA048484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048373":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":52,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031501":null,"HPA031502":null,"HPA031503":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.94e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"}},{"Gene":"ERLIN1","Gene synonym":["C10orf69","Erlin-1","KE04","SPFH1","SPG62"],"Ensembl":"ENSG00000107566","Gene description":"ER lipid raft associated 1","Uniprot":["O75477"],"Chromosome":"10","Position":"100150094-100186033","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Cholesterol metabolism","Lipid metabolism","Steroid metabolism","Sterol metabolism"],"Molecular function":null,"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"106.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Monocyte progenitors":"142.2","Neutrophil progenitors":"215.5","Neutrophils":"150.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"215.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Urothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"25599907.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011252"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":56,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA011252":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.35e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.49e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"}},{"Gene":"ERMARD","Gene synonym":["C6orf70","dJ266L20.3","FLJ11152"],"Ensembl":"ENSG00000130023","Gene description":"ER membrane associated RNA degradation","Uniprot":["Q5T6L9"],"Chromosome":"6","Position":"169751622-169781600","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"37.8","Early spermatids":"41.3","Ependymal cells":"40.2","Late primary spermatocytes":"52.1","Late spermatids":"65.0","Oocytes":"170.4","Podocytes":"46.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"170.4","Spermatogenic cell types":"65.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041741"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041741":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"}},{"Gene":"ERMP1","Gene synonym":["FLJ23309","FXNA","KIAA1815"],"Ensembl":"ENSG00000099219","Gene description":"Endoplasmic reticulum metallopeptidase 1","Uniprot":["Q7Z2K6"],"Chromosome":"9","Position":"5749832-5879537","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"20.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"486.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"486.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"1.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland ductal cells","Skin - Mitotic cells (Skin)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"186586949.0"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA055582"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":56,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055582":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"}},{"Gene":"ERO1B","Gene synonym":["ERO1-L(beta)","Ero1beta","ERO1LB"],"Ensembl":"ENSG00000086619","Gene description":"Endoplasmic reticulum oxidoreductase 1 beta","Uniprot":["Q86YB8"],"Chromosome":"1","Position":"236214681-236282019","Protein class":["Predicted intracellular proteins"],"Biological process":["Electron transport","Transport"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"pancreas":"172.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric chief cells":"323.2","Pancreatic acinar cells":"430.8","Pancreatic islet cells":"742.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pancreatic islet cells":"742.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"68747035.6","Pancreatic islets":"274600071.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"47693047.8"},"Antibody":["HPA028085"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028085":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.11e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"}},{"Gene":"ERVW-1","Gene synonym":["envW","ERVWE1","HERV-7q","HERV-W","HERV-W-ENV","HERVW"],"Ensembl":"ENSG00000242950","Gene description":"Endogenous retrovirus group W member 1, envelope","Uniprot":["Q9UQF0"],"Chromosome":"7","Position":"92468380-92477986","Protein class":["Essential proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"placenta":"51.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cytotrophoblasts":"306.9","Syncytiotrophoblasts":"1171.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Trophoblast cells":"1171.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"40","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"61.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Sarcoma":"24.7","testis cancer":"24.2"},"RNA tissue cell type enrichment":["Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"47000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-3"}},{"Gene":"ESCO1","Gene synonym":["EFO1","ESO1","KIAA1911"],"Ensembl":"ENSG00000141446","Gene description":"Establishment of sister chromatid cohesion N-acetyltransferase 1","Uniprot":["Q5FWF5"],"Chromosome":"18","Position":"21529284-21600884","Protein class":["Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"233.4","Neutrophils":"225.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3548","Protein cell type specific Intensity":{"Granulosa cells":"354790.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042497"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042497":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"ESPL1","Gene synonym":["ESP1","KIAA0165","SEPA"],"Ensembl":"ENSG00000135476","Gene description":"Extra spindle pole bodies like 1, separase","Uniprot":["Q14674"],"Chromosome":"12","Position":"53268299-53293638","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Chromosome partition"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"8.0","esophagus":"14.2","lymphoid tissue":"9.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Esophageal apical cells":"161.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"161.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"16.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"5125","Protein cell type specific Intensity":{"Granulosa cells":"512518.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"14171","Protein tissue specific Intensity":{"intestine":"1417091.0"},"Antibody":["CAB012185","HPA073188"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB012185":null,"HPA073188":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.77e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"}},{"Gene":"ESR1","Gene synonym":["ER-alpha","Era","ESR","NR3A1"],"Ensembl":"ENSG00000091831","Gene description":"Estrogen receptor 1","Uniprot":["P03372"],"Chromosome":"6","Position":"151656691-152129619","Protein class":["Cancer-related genes","Disease related genes","FDA approved drug targets","Human disease related genes","Nuclear receptors","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Receptor"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets","Osteoporosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"80.7","endometrium 1":"103.7","fallopian tube":"61.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"391.0","Breast hormone-responsive cells":"507.0","Endometrial ciliated cells":"572.2","Endometrial glandular cells":"463.2","Endometrial luminal cells":"449.7","Endometrial stromal cells":"737.2","Epicardial cells":"436.6","Epididymal efferent duct absorptive cells":"946.8","Fallopian secretory cells":"405.0","Gonadotrophs":"1651.4","Hepatocytes":"394.3","Lactotrophs":"377.5","Retinal horizontal cells":"803.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"946.8","Neuronal cells":"803.4","Pituitary endocrine cells":"1651.4","Stromal cells":"737.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"132.3","Uterine Corpus Endometrial Carcinoma (TCGA)":"57.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"20.8"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Kidney - Fibroblasts","Liver - Hepatocytes","Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"880002.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2472","Protein tissue specific Intensity":{"fallopian tube":"247248.4"},"Antibody":["CAB000037","HPA000449","HPA000450","CAB055099","CAB072858"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":572,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB000037":null,"CAB055099":null,"CAB072858":null,"HPA000449":null,"HPA000450":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.01e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.29e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.09e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"}},{"Gene":"ESRP2","Gene synonym":["FLJ21918","RBM35B"],"Ensembl":"ENSG00000103067","Gene description":"Epithelial splicing regulatory protein 2","Uniprot":["Q9H6T0"],"Chromosome":"16","Position":"68229033-68238102","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"64.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"46.9","Esophageal apical cells":"142.2","Esophageal suprabasal cells":"100.3","Late spermatids":"141.9","Syncytiotrophoblasts":"71.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"142.2","Spermatogenic cell types":"141.9","Suprabasal cells":"100.3","Trophoblast cells":"71.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"2.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Breast - Breast glandular cells","Colon - Colon enterocytes","Lung - Alveolar cells type 2","Pituitary gland - Corticotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"6081214.0","Hepatocytes":"6530836.9","Keratinocytes":"10056851.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"1327934.3","lung":"1010642.1","pancreas":"356088.2","salivary gland":"1239678.1"},"Antibody":["HPA040751","HPA048597","HPA048618"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA040751":null,"HPA048597":null,"HPA048618":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.27e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"ESRRG","Gene synonym":["ERR-gamma","ERRg","NR3B3"],"Ensembl":"ENSG00000196482","Gene description":"Estrogen related receptor gamma","Uniprot":["P62508"],"Chromosome":"1","Position":"216503246-217137755","Protein class":["FDA approved drug targets","Nuclear receptors","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"27.1","parathyroid gland":"43.5","retina":"33.5","stomach 1":"33.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"2711.2","Distal convoluted tubule cells":"6180.5","Loop of henle epithelial cells":"3812.1","Parietal cells":"1371.9","Renal collecting duct intercalated cells":"3411.9","Renal connecting tubule cells":"4138.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"4138.3","Glial cells":"2711.2","Renal nephron cells":"6180.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"2637.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"18.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"14.7"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Prostate - Prostate glandular cells","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Skin - Eccrine sweat gland cells","Stomach - Parietal cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"650078.5","Distal tubules":"1523943.6","Large ducts":"2068782.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"602","Protein tissue specific Intensity":{"salivary gland":"60150.6"},"Antibody":["HPA044678"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":25,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044678":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.35e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"}},{"Gene":"ETDA","Gene synonym":[],"Ensembl":"ENSG00000238210","Gene description":"Embryonic testis differentiation homolog A","Uniprot":["Q3ZM63"],"Chromosome":"X","Position":"135252061-135253583","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"testis":"16.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Early spermatids":"49.5","Late primary spermatocytes":"53.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"47","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"53.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ETDB","Gene synonym":["LINC00633"],"Ensembl":"ENSG00000224107","Gene description":"Embryonic testis differentiation homolog B","Uniprot":["P0DPP9"],"Chromosome":"X","Position":"135118955-135120526","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"31","RNA tissue specific nTPM":{"testis":"11.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"16.7","Late primary spermatocytes":"15.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"28","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"16.7"},"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ETFRF1","Gene synonym":["LYRM5"],"Ensembl":"ENSG00000205707","Gene description":"Electron transfer flavoprotein regulatory factor 1","Uniprot":["Q6IPR1"],"Chromosome":"12","Position":"25195216-25209645","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"220.2","Late primary spermatocytes":"714.0","Parietal cells":"275.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"714.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"107.2"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"6237617.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"3738352.9"},"Antibody":["HPA044255"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044255":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.85e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.74e-4"}},{"Gene":"EVA1C","Gene synonym":["B18","B19","C21orf63","C21orf64","FAM176C","PRED34"],"Ensembl":"ENSG00000166979","Gene description":"Eva-1 homolog C","Uniprot":["P58658"],"Chromosome":"21","Position":"32412006-32515397","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"412.9","Respiratory ciliated cells":"420.4","Respiratory secretory cells":"410.2","Vascular endothelial cells":"442.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"373.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"1.1","gdT-cell":"3.1","MAIT T-cell":"3.8","memory CD4 T-cell":"3.2","memory CD8 T-cell":"3.2","naive CD8 T-cell":"1.6","NK-cell":"3.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"1.1","NK-cells":"3.2","T-cells":"3.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Skeletal muscle - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"96127","Protein cell type specific Intensity":{"Fallopian tube cells":"9385868.2","Macrophages":"9839559.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"94372","Protein tissue specific Intensity":{"fallopian tube":"11260543.0","ovary":"7613776.3"},"Antibody":["HPA015720","HPA029944","CAB034174","HPA076996"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB034174":null,"HPA015720":null,"HPA029944":null,"HPA076996":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"}},{"Gene":"EVI5L","Gene synonym":[],"Ensembl":"ENSG00000142459","Gene description":"Ecotropic viral integration site 5 like","Uniprot":["Q96CN4"],"Chromosome":"19","Position":"7830218-7864976","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"41.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"102.1","Oligodendrocyte progenitor cells":"85.5","Oligodendrocytes":"92.8","Retinal amacrine cells":"72.9","Retinal horizontal cells":"70.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"92.8","Spermatogenic cell types":"102.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"5821995.6","cerebral cortex":"11627109.0"},"Antibody":["HPA043099"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA043099":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"EVX2","Gene synonym":[],"Ensembl":"ENSG00000174279","Gene description":"Even-skipped homeobox 2","Uniprot":["Q03828"],"Chromosome":"2","Position":"176077472-176083962","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"prostate":"1.2","seminal vesicle":"1.5","testis":"2.8","vagina":"1.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"14.1","Late spermatids":"7.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"14.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"pons":"2.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"1.1"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"13","RNA mouse brain regional specific nTPM":{"midbrain":"1.3","pons and medulla":"1.1"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041576"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041576":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EWSR1","Gene synonym":["EWS"],"Ensembl":"ENSG00000182944","Gene description":"EWS RNA binding protein 1","Uniprot":["Q01844"],"Chromosome":"22","Position":"29268009-29300525","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Calmodulin-binding","Repressor","RNA-binding"],"Disease involvement":["Cancer-related genes","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":138,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"CAB004230":null,"HPA051771":null,"HPA062953":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.65e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":13,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Intermediate filaments"],"Antibody RRID":{"HPA002906":null,"HPA005848":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"}},{"Gene":"EXOC5","Gene synonym":["SEC10","SEC10L1","SEC10P"],"Ensembl":"ENSG00000070367","Gene description":"Exocyst complex component 5","Uniprot":["O00471"],"Chromosome":"14","Position":"57200507-57268905","Protein class":["Essential proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Exocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":65,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA020485":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":81,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA024792":null,"HPA065103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.93e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"}},{"Gene":"EXOSC8","Gene synonym":["bA421P11.3","CIP3","EAP2","OIP2","p9","RRP43","Rrp43p"],"Ensembl":"ENSG00000120699","Gene description":"Exosome component 8","Uniprot":["Q96B26"],"Chromosome":"13","Position":"36998816-37025881","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"265.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"265.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":96,"Subcellular main location":["Nucleoli fibrillar center","Mitotic chromosome"],"Subcellular additional location":["Nucleoplasm","Vesicles","Cytosol"],"Antibody RRID":{"CAB034240":null,"HPA039702":null,"HPA043942":null,"HPA075230":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.42e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"}},{"Gene":"EXOSC9","Gene synonym":["p5","p6","PM\/Scl-75","PMSCL1","RRP45","Rrp45p"],"Ensembl":"ENSG00000123737","Gene description":"Exosome component 9","Uniprot":["Q06265"],"Chromosome":"4","Position":"121801318-121817021","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"106.0","Early spermatids":"131.2","Late primary spermatocytes":"313.4","Oocytes":"101.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"313.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":38,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB070171":null,"HPA041838":null,"HPA048257":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.81e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"}},{"Gene":"EXPH5","Gene synonym":["SLAC2-B"],"Ensembl":"ENSG00000110723","Gene description":"Exophilin 5","Uniprot":["Q8NEV8"],"Chromosome":"11","Position":"108505435-108593768","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Epidermolysis bullosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"15.1","skin 1":"24.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"272.9","Endometrial ciliated cells":"345.9","Endometrial glandular cells":"405.3","Ependymal cells":"251.4","Podocytes":"908.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"405.3","Renal nephron cells":"908.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"275.4","choroid plexus epithelial cell":"159.6","ependymal cell":"220.0","upper rhombic lip":"208.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"cerebellum":"144.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"cerebellum":"20.9","cerebral cortex":"6.7"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"8","RNA pig brain regional specific nTPM":{"cerebellum":"41.9"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"11909887.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB080597","CAB080733"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB080597":null,"CAB080733":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":9,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Vesicles","Primary cilium"],"Antibody RRID":{"HPA028917":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.69e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Endothelial cells","Kidney - Fibroblasts","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1576679.0","Fallopian tube cells":"418814.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"429","Protein tissue specific Intensity":{"fallopian tube":"42907.9"},"Antibody":["HPA004805","HPA038771","HPA038772"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA004805":null,"HPA038771":null,"HPA038772":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EYS","Gene synonym":["bA166P24.2","bA307F22.3","bA74E24.1","C6orf178","C6orf179","C6orf180","dJ1018A4.2","dJ303F19.1","EGFL10","EGFL11","RP25","SPAM"],"Ensembl":"ENSG00000188107","Gene description":"Eyes shut homolog","Uniprot":["Q5T1H1"],"Chromosome":"6","Position":"63719980-65707226","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"37","RNA tissue specific nTPM":{"retina":"23.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"6630.6","Rod photoreceptor cells":"4150.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Neuronal cells":"6630.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"421.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"2.4"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol","Flagellar centriole"],"Subcellular additional location":null,"Antibody RRID":{"HPA027103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"EZH2","Gene synonym":["ENX-1","EZH1","KMT6","KMT6A"],"Ensembl":"ENSG00000106462","Gene description":"Enhancer of zeste 2 polycomb repressive complex 2 subunit","Uniprot":["Q15910"],"Chromosome":"7","Position":"148807257-148884321","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Methyltransferase","Repressor","Transferase"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"23.9","lymphoid tissue":"34.1","testis":"24.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"263.2","Late primary spermatocytes":"222.2","Megakaryocyte progenitors":"167.3","Monocyte progenitors":"269.0","Neutrophil progenitors":"246.2","Respiratory deuterosomal cells":"180.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"7.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":275,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB009589":null,"HPA029131":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.91e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.43e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"}},{"Gene":"F5","Gene synonym":[],"Ensembl":"ENSG00000198734","Gene description":"Coagulation factor V","Uniprot":["P12259"],"Chromosome":"1","Position":"169511951-169586588","Protein class":["Candidate cardiovascular disease genes","Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Blood coagulation","Hemostasis"],"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets","Thrombophilia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"77.1","liver":"164.8","placenta":"44.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"163.8","Cholangiocytes":"72.0","Choroid plexus epithelial cells":"441.9","Cytotrophoblasts":"122.6","Epididymal efferent duct ciliated cells":"103.7","Hepatocytes":"487.0","Neutrophils":"312.3","Podocytes":"90.9","Syncytiotrophoblasts":"73.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"441.9","Hepatocytes":"487.0","Myocytes":"163.8","Neutrophils":"312.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"358.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"78.0"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"22","RNA brain regional specific nTPM":{"choroid plexus":"306.3"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"classical monocyte":"4.1","eosinophil":"8.1","neutrophil":"7.0","T-reg":"6.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"8.1","monocytes":"4.1","T-cells":"6.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"17.9"},"RNA tissue cell type enrichment":["Kidney - Podocytes","Liver - Hepatocytes","Lung - Neutrophils_2","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Urothelial cells","Skin - Eccrine sweat gland cells","Spleen - Neutrophils_2","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"basal ganglia":"2.7","hippocampal formation":"6.6","pons and medulla":"4.4","thalamus":"5.5"},"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"7","RNA pig brain regional specific nTPM":{"amygdala":"53.1","basal ganglia":"46.2","cerebral cortex":"89.3","hippocampal formation":"80.9","olfactory bulb":"37.0"},"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"3601785.2","Macrophages":"3402072.6","T-cells":"3720174.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"15998991.2"},"Antibody":["HPA002036"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":"Secreted to blood","Secretome function":"Blood coagulation","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":7670000000,"Blood concentration - Conc. blood MS [pg\/L]":"5500000000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":4,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA002036":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.66e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.55e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"}},{"Gene":"FAAH","Gene synonym":["FAAH-1"],"Ensembl":"ENSG00000117480","Gene description":"Fatty acid amide hydrolase","Uniprot":["O00519"],"Chromosome":"1","Position":"46394317-46413848","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"84.5","Late primary spermatocytes":"157.1","Late spermatids":"222.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"222.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"106.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"29.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"32.7"},"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Breast - Breast glandular cells","Breast - Breast glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"51609559.4","Proximal tubules":"27723883.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA007425"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":6,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA007425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.86e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.65e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.51e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.21e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"}},{"Gene":"FAAP24","Gene synonym":["C19orf40","FLJ46828","MGC32020"],"Ensembl":"ENSG00000131944","Gene description":"FA core complex associated protein 24","Uniprot":["Q9BTP7"],"Chromosome":"19","Position":"32972209-32978229","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"14.6","Early primary spermatocytes":"12.8","Extravillous trophoblasts":"19.8","Late primary spermatocytes":"42.2","Late spermatids":"17.6","Migrating cytotrophoblasts":"13.0","Oocytes":"13.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"42.2","Trophoblast cells":"19.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041168"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA041168":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.68e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"}},{"Gene":"FABP12","Gene synonym":[],"Ensembl":"ENSG00000197416","Gene description":"Fatty acid binding protein 12","Uniprot":["A6NFH5"],"Chromosome":"8","Position":"81524981-81590139","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"retina":"52.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"163.5","Early spermatids":"118.8","Esophageal basal cells":"47.9","Esophageal suprabasal cells":"58.2","Late primary spermatocytes":"38.9","Late spermatids":"207.1","Rod photoreceptor cells":"314.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"314.9","Spermatogenic cell types":"207.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"1.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"1.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044041":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FAF1","Gene synonym":["CGI-03","hFAF1","HFAF1s","UBXD12","UBXN3A"],"Ensembl":"ENSG00000185104","Gene description":"Fas associated factor 1","Uniprot":["Q9UNN5"],"Chromosome":"1","Position":"50437028-50960267","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"22000","Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":77,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Acrosome","Equatorial segment","Perinuclear theca"],"Antibody RRID":{"CAB072814":null,"HPA018253":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.14e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"}},{"Gene":"FAHD2A","Gene synonym":["CGI-105"],"Ensembl":"ENSG00000115042","Gene description":"Fumarylacetoacetate hydrolase domain containing 2A","Uniprot":["Q96GK7"],"Chromosome":"2","Position":"95402708-95416616","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"107.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"60.3","Enterocytes":"64.9","Lacrimal acinar cells":"76.1","Late spermatids":"52.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"76.1","Enterocytes":"64.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"110187864.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"96097917.6"},"Antibody":["HPA042145","HPA044987","CAB045971","CAB045972"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB045971":null,"CAB045972":null,"HPA042145":null,"HPA044987":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"FAHD2B","Gene synonym":["DKFZp434N062"],"Ensembl":"ENSG00000144199","Gene description":"Fumarylacetoacetate hydrolase domain containing 2B","Uniprot":["Q6P2I3"],"Chromosome":"2","Position":"97083583-97094882","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"259.1","Epididymal principal cells":"117.6","Late primary spermatocytes":"120.2","Late spermatids":"302.7","Oocytes":"96.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Oocytes":"96.7","Reproductive supporting cells":"117.6","Spermatogenic cell types":"302.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042145":null,"HPA044987":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.55e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"}},{"Gene":"FAIM2","Gene synonym":["KIAA0950","LFG","LFG2","LIFEGUARD","NMP35","TMBIM2"],"Ensembl":"ENSG00000135472","Gene description":"Fas apoptotic inhibitory molecule 2","Uniprot":["Q9BWQ8"],"Chromosome":"12","Position":"49866896-49904217","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"309.1","parathyroid gland":"91.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"127.6","Bergmann glia":"56.5","Brain excitatory neurons":"104.1","Brain inhibitory neurons":"147.0","Early spermatids":"189.5","Ependymal cells":"108.9","Late primary spermatocytes":"179.9","Late spermatids":"57.9","Oligodendrocyte progenitor cells":"63.4","Oligodendrocytes":"102.3","Other brain neurons":"148.6","Retinal amacrine cells":"94.3","Retinal bipolar cells":"106.1","Retinal horizontal cells":"138.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"127.6","Ciliated cells":"108.9","Glial cells":"102.3","Neuronal cells":"148.6","Spermatogenic cell types":"189.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"74.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"3.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"T-cells":"3.0"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"38.5"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Kidney - Fibroblasts","Lung - Fibroblasts_2","Minor Salivary Gland - Fibroblasts","Pituitary gland - Undifferentiated cells (Pituitary gland)","Prostate - Fibroblasts","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"948","Protein cell type specific Intensity":{"Microglia and Neuropil":"94779.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"16582","Protein tissue specific Intensity":{"cerebral cortex":"1658191.9"},"Antibody":["HPA018790","HPA048800"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Intermediate filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":4,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA018790":null,"HPA048800":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA021459":null,"HPA079514":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":12,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035869":null,"HPA035870":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.07e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.91e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"}},{"Gene":"FAM117A","Gene synonym":[],"Ensembl":"ENSG00000121104","Gene description":"Family with sequence similarity 117 member A","Uniprot":["Q9C073"],"Chromosome":"17","Position":"49710332-49789180","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"72.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"193.6","Erythrocyte progenitors":"168.3","Hematopoietic stem cells":"207.2","Megakaryocyte-Erythroid progenitors":"255.4","NK-cells":"102.8","Thymocytes":"169.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"193.6","Megakaryocytes":"255.4","Stem cells":"207.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"141.1","leukocyte":"120.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"choroid plexus":"76.6"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"50.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"62.9"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA022531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.43e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041644":null,"HPA042100":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.39e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"}},{"Gene":"FAM135A","Gene synonym":["FLJ20176","KIAA1411"],"Ensembl":"ENSG00000082269","Gene description":"Family with sequence similarity 135 member A","Uniprot":["Q9P2D6"],"Chromosome":"6","Position":"70412941-70561174","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"28.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"770.5","Prostatic glandular cells":"762.7","Retinal horizontal cells":"1274.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"770.5","Glandular cells":"762.7","Neuronal cells":"1274.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA031743":null,"HPA031744":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.86e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.23e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.37e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"}},{"Gene":"FAM135B","Gene synonym":["C8ORFK32"],"Ensembl":"ENSG00000147724","Gene description":"Family with sequence similarity 135 member B","Uniprot":["Q49AJ0"],"Chromosome":"8","Position":"138130023-138497261","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"adrenal gland":"2.5","brain":"6.6","retina":"9.1","testis":"3.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"159.6","Bergmann glia":"163.3","Brain excitatory neurons":"210.0","Brain inhibitory neurons":"262.3","Cone photoreceptor cells":"604.5","Early spermatids":"517.9","Ependymal cells":"252.5","Lactotrophs":"230.7","Late primary spermatocytes":"226.0","Late spermatids":"210.7","Retinal bipolar cells":"706.4","Thyrotrophs":"270.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"252.5","Neuronal cells":"706.4","Pituitary endocrine cells":"270.1","Spermatogenic cell types":"517.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Pancreas - Alpha cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"521","Protein cell type specific Intensity":{"Microglia and Neuropil":"45190.1","Neurons":"59031.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023911","HPA023950","HPA024815"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":3,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023911":null,"HPA023950":null,"HPA024815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FAM149B1","Gene synonym":["KIAA0974"],"Ensembl":"ENSG00000138286","Gene description":"Family with sequence similarity 149 member B1","Uniprot":["Q96BN6"],"Chromosome":"10","Position":"73168119-73244504","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039189":null,"HPA039859":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.91e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"}},{"Gene":"FAM151A","Gene synonym":["C1orf179","MGC27169"],"Ensembl":"ENSG00000162391","Gene description":"Family with sequence similarity 151 member A","Uniprot":["Q8WW52"],"Chromosome":"1","Position":"54609181-54623556","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"intestine":"68.2","kidney":"163.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Cardiomyocytes":"233.8","Enterocytes":"469.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Enterocytes":"469.9","Myocytes":"233.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"16.8","ependymal cell":"12.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"15.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"2.7","Gastric cancer":"2.6","liver cancer":"2.7"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6900","Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016840":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"FAM161A","Gene synonym":["FLJ13305","RP28"],"Ensembl":"ENSG00000170264","Gene description":"FAM161 centrosomal protein A","Uniprot":["Q3B820"],"Chromosome":"2","Position":"61824848-61854143","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"retina":"26.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"157.4","Late primary spermatocytes":"168.2","Late spermatids":"474.9","Respiratory ciliated cells":"107.6","Retinal pigment epithelial cells":"162.0","Rod photoreceptor cells":"395.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"395.5","Pigment cells":"162.0","Spermatogenic cell types":"474.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":125,"Subcellular main location":["Centrosome","Basal body","Flagellar centriole"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA032119":null,"HPA064830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"}},{"Gene":"FAM161B","Gene synonym":["C14orf44","FLJ31697"],"Ensembl":"ENSG00000156050","Gene description":"FAM161 centrosomal protein B","Uniprot":["Q96MY7"],"Chromosome":"14","Position":"73931501-73950414","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"35.3","Early spermatids":"85.7","Late spermatids":"195.4","Retinal ganglion cells":"34.8","Rod photoreceptor cells":"31.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"195.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"35.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"19.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"28303","Protein cell type specific Intensity":{"Fallopian tube cells":"2830309.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"27498","Protein tissue specific Intensity":{"fallopian tube":"2749838.3"},"Antibody":["HPA019125"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":54,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA019125":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"}},{"Gene":"FAM163A","Gene synonym":["C1orf76","MGC16664","NDSP"],"Ensembl":"ENSG00000143340","Gene description":"Family with sequence similarity 163 member A","Uniprot":["Q96GL9"],"Chromosome":"1","Position":"179743291-179816198","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"14.9","pituitary gland":"29.7","testis":"12.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Lactotrophs":"923.4","Somatotrophs":"490.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"923.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"164.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"pons":"44.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"15","RNA cell line specific nTPM":{"Adrenocortical cancer":"45.6","Neuroblastoma":"56.7"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":26,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FAM167A","Gene synonym":["C8orf13","DIORA-1"],"Ensembl":"ENSG00000154319","Gene description":"Family with sequence similarity 167 member A","Uniprot":["Q96KS9"],"Chromosome":"8","Position":"11421476-11475908","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"23.9","thyroid gland":"49.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"32.4","Basal prostatic cells":"6.9","Bergmann glia":"43.3","Choroid plexus epithelial cells":"17.7","Ependymal cells":"9.1","Late spermatids":"8.3","Loop of henle epithelial cells":"8.6","Mucous neck cells":"7.9","Renal collecting duct principal cells":"6.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"17.7","Glial cells":"43.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"39.3","Bergmann glia":"54.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"16.1","Thyroid Carcinoma (TCGA)":"29.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"32.4"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 33: Thyroid gland - Tissue development","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":45,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA023915":null,"HPA030426":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037900":null,"HPA037902":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":132,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA019539":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA053222":null,"HPA055440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"}},{"Gene":"FAM181A","Gene synonym":["C14orf152"],"Ensembl":"ENSG00000140067","Gene description":"Family with sequence similarity 181 member A","Uniprot":["Q8N9Y4"],"Chromosome":"14","Position":"93918894-93929608","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"13.9","testis":"32.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Astrocytes":"10.1","Bergmann glia":"13.4","Ependymal cells":"20.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Ciliated cells":"20.5","Glial cells":"13.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"astrocyte":"11.6","Bergmann glia":"20.6","ependymal cell":"27.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.2","Ovary Serous Cystadenocarcinoma (TCGA)":"5.1","Uterine Corpus Endometrial Carcinoma (TCGA)":"3.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001603":null,"HPA018522":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"}},{"Gene":"FAM184A","Gene synonym":["C6orf60","FLJ13942"],"Ensembl":"ENSG00000111879","Gene description":"Family with sequence similarity 184 member A","Uniprot":["Q8NB25"],"Chromosome":"6","Position":"118959763-119149387","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"255.6","Astrocytes":"327.2","Bergmann glia":"334.5","Corticotrophs":"292.7","Cytotrophoblasts":"228.5","Ependymal cells":"471.1","Pituicytes\/FSCs":"305.2","Pituitary stem cells":"228.7","Respiratory ciliated cells":"225.1","Salivary myoepithelial cells":"263.9","Syncytiotrophoblasts":"794.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"471.1","Glial cells":"334.5","Trophoblast cells":"794.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"12.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"8.9"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":16,"Subcellular main location":["Centriolar satellite","Basal body","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA034571":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA047128":null,"HPA064735":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":1,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Centrosome","Basal body"],"Antibody RRID":{"HPA039736":null,"HPA040028":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":6,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA038182":null,"HPA062025":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":28,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA051840":null,"HPA062239":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.46e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"}},{"Gene":"FAM227A","Gene synonym":[],"Ensembl":"ENSG00000184949","Gene description":"Family with sequence similarity 227 member A","Uniprot":["F5H4B4"],"Chromosome":"22","Position":"38578118-38656629","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"4.7","testis":"4.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"207.7","Early spermatids":"144.3","Endometrial ciliated cells":"175.8","Ependymal cells":"303.9","Epididymal efferent duct ciliated cells":"88.6","Fallopian tube ciliated cells":"136.5","Lactotrophs":"81.3","Late spermatids":"88.1","Respiratory ciliated cells":"363.7","Respiratory deuterosomal cells":"79.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"363.7","Pituitary endocrine cells":"81.3","Spermatogenic cell types":"144.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"162.7","ependymal cell":"321.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA003077":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"}},{"Gene":"FAM227B","Gene synonym":["C15orf33","FLJ32800"],"Ensembl":"ENSG00000166262","Gene description":"Family with sequence similarity 227 member B","Uniprot":["Q96M60"],"Chromosome":"15","Position":"49326962-49620929","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"614.6","Epicardial cells":"413.9","Fibro-adipogenic progenitors":"352.7","Myonuclei":"192.3","Oocytes":"225.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"413.9","Fibro-adipogenic progenitors":"352.7","Myocytes":"614.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"167.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049774":null,"HPA061695":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.12e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.28e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.63e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"}},{"Gene":"FAM228A","Gene synonym":["C2orf84","FLJ30851"],"Ensembl":"ENSG00000186453","Gene description":"Family with sequence similarity 228 member A","Uniprot":["Q86W67"],"Chromosome":"2","Position":"24175053-24200849","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"17","RNA tissue specific nTPM":{"testis":"33.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"52.7","Early spermatids":"66.7","Late primary spermatocytes":"249.2","Late spermatids":"15.6","Oocytes":"69.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Oocytes":"69.1","Spermatogenic cell types":"249.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Adipocytes (Breast)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA075817"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":16,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA075817":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.93e-4"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FAM228B","Gene synonym":[],"Ensembl":"ENSG00000219626","Gene description":"Family with sequence similarity 228 member B","Uniprot":["P0C875"],"Chromosome":"2","Position":"24076526-24169640","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"137.8","Late spermatids":"129.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Liver - Hepatic stellate cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"246","Protein cell type specific Intensity":{"Fallopian tube cells":"24632.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052598","HPA063357"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA052598":null,"HPA063357":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.59e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"}},{"Gene":"FAM229B","Gene synonym":["C6orf225","DKFZp586F0922","LOC619208"],"Ensembl":"ENSG00000203778","Gene description":"Family with sequence similarity 229 member B","Uniprot":["Q4G0N7"],"Chromosome":"6","Position":"112087591-112102790","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"427.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"3604.4","Late primary spermatocytes":"2623.1","Late spermatids":"10748.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"10748.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"96.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036068"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Golgi apparatus"],"Antibody RRID":{"HPA036068":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.88e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"}},{"Gene":"FAM237A","Gene synonym":[],"Ensembl":"ENSG00000235118","Gene description":"Family with sequence similarity 237 member A","Uniprot":["A0A1B0GTK4"],"Chromosome":"2","Position":"206642487-206649365","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"1.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"5.2","Late primary spermatocytes":"8.3","Late spermatids":"3.8","Other brain neurons":"2.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"2.4","Spermatogenic cell types":"8.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"3.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052490":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":2080000,"Blood concentration - Conc. blood MS [pg\/L]":"85000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":7,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB034131":null,"HPA015885":null,"HPA029777":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.29e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA000610":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA043271":null,"HPA067321":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"}},{"Gene":"FAM81B","Gene synonym":["FLJ25333"],"Ensembl":"ENSG00000153347","Gene description":"Family with sequence similarity 81 member B","Uniprot":["Q96LP2"],"Chromosome":"5","Position":"95391366-95450454","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"choroid plexus":"58.9","fallopian tube":"45.4","testis":"78.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"175.1","Early spermatids":"955.3","Endometrial ciliated cells":"213.5","Ependymal cells":"238.0","Epididymal efferent duct ciliated cells":"382.8","Fallopian tube ciliated cells":"458.0","Late primary spermatocytes":"323.4","Late spermatids":"2644.1","Respiratory ciliated cells":"395.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2644.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"31","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"187.0","ependymal cell":"292.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"11.2"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"34.5"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"62","RNA blood cell specific nTPM":{"basophil":"6.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"62","RNA blood lineage specific nTPM":{"granulocytes":"6.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.3"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA072554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - 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Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-8"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA051207":null,"HPA064657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"FAM8A1","Gene synonym":["AHCP"],"Ensembl":"ENSG00000137414","Gene description":"Family with sequence similarity 8 member A1","Uniprot":["Q9UBU6"],"Chromosome":"6","Position":"17600302-17611719","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"911.1","Late primary spermatocytes":"267.0","Late spermatids":"269.3","Neutrophil progenitors":"121.9","Neutrophils":"240.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neutrophils":"240.2","Spermatogenic cell types":"911.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"5.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":25,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA044698":null,"HPA073675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.70e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.32e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":10,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Cytokinetic bridge","Primary cilium"],"Antibody RRID":{"HPA048198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"}},{"Gene":"FANCC","Gene synonym":["FA3","FAC","FACC"],"Ensembl":"ENSG00000158169","Gene description":"FA complementation group C","Uniprot":["Q00597"],"Chromosome":"9","Position":"95099054-95426796","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Fanconi anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"23.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"495.0","Myonuclei":"298.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"495.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"basophil":"10.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"10.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017793","HPA030771"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":48,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB017793":null,"HPA030771":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.08e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.70e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"}},{"Gene":"FANCF","Gene synonym":["FAF"],"Ensembl":"ENSG00000183161","Gene description":"FA complementation group F","Uniprot":["Q9NPI8"],"Chromosome":"11","Position":"22622533-22625823","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Fanconi anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"173.2","Late primary spermatocytes":"113.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"173.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA008899":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.00e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"}},{"Gene":"FANCM","Gene synonym":["FAAP250","KIAA1596"],"Ensembl":"ENSG00000187790","Gene description":"FA complementation group M","Uniprot":["Q8IYD8"],"Chromosome":"14","Position":"45135930-45200890","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding","Helicase","Hydrolase"],"Disease involvement":["Disease variant","Premature ovarian failure"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"6.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"101.8","Late spermatids":"345.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"345.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA055144":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.72e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.92e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"}},{"Gene":"FANK1","Gene synonym":[],"Ensembl":"ENSG00000203780","Gene description":"Fibronectin type III and ankyrin repeat domains 1","Uniprot":["Q8TC84"],"Chromosome":"10","Position":"125896564-126009592","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"64.6","fallopian tube":"32.9","testis":"56.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"370.0","Early spermatids":"691.1","Endometrial ciliated cells":"340.5","Ependymal cells":"605.1","Epididymal efferent duct ciliated cells":"369.8","Fallopian tube ciliated cells":"337.9","Late primary spermatocytes":"505.0","Late spermatids":"815.4","Respiratory ciliated cells":"685.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"685.5","Spermatogenic cell types":"815.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"295.4","ependymal cell":"642.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"16","RNA blood cell specific nTPM":{"T-reg":"61.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"614","RNA blood lineage specific nTPM":{"T-cells":"61.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"51368","Protein cell type specific Intensity":{"Capillaries":"7513021.6","Fallopian tube cells":"2760639.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038413"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038413":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":108000000,"Blood concentration - Conc. blood MS [pg\/L]":"58000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059739":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.63e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.40e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.77e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"}},{"Gene":"FAR2","Gene synonym":["FLJ10462","MLSTD1","SDR10E2"],"Ensembl":"ENSG00000064763","Gene description":"Fatty acyl-CoA reductase 2","Uniprot":["Q96K12"],"Chromosome":"12","Position":"29149016-29341121","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"18.1","intestine":"21.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"713.9","Microglia":"267.0","Neutrophil progenitors":"903.9","Neutrophils":"523.8","Syncytiotrophoblasts":"641.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"713.9","Neutrophils":"903.9","Trophoblast cells":"641.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"39.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Macrophages","Prostate - Endothelial cells","Skin - Sebaceous gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"341","Protein tissue specific Intensity":{"skin":"34065.8"},"Antibody":["HPA015884"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":4,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA015884":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.91e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.81e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"}},{"Gene":"FARS2","Gene synonym":["dJ236A3.1","FARS1","mtPheRS"],"Ensembl":"ENSG00000145982","Gene description":"Phenylalanyl-tRNA synthetase 2, mitochondrial","Uniprot":["O95363"],"Chromosome":"6","Position":"5261044-5829192","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"890.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"890.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018148","HPA028836"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":63,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018148":null,"HPA028836":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.38e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"FARSB","Gene synonym":["FARSLB","FRSB","PheHB"],"Ensembl":"ENSG00000116120","Gene description":"Phenylalanyl-tRNA synthetase subunit beta","Uniprot":["Q9NSD9"],"Chromosome":"2","Position":"222566899-222656092","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase"],"Disease involvement":["Disease variant","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oocytes":"202.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"202.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"526350415.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036677","HPA036678","HPA061398"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"37000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036677":null,"HPA036678":null,"HPA061398":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.22e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.60e-13"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.30e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.39e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"}},{"Gene":"FAT2","Gene synonym":["CDHF8","CDHR9","HFAT2","MEGF1"],"Ensembl":"ENSG00000086570","Gene description":"FAT atypical cadherin 2","Uniprot":["Q9NYQ8"],"Chromosome":"5","Position":"151504092-151591331","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"223.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"86.8","Basal prostatic cells":"55.9","Brain excitatory neurons":"110.4","Esophageal basal cells":"54.0","Esophageal suprabasal cells":"76.1","Ocular epithelial cells":"123.9","Papillary tip epithelial cells":"53.8","Prostatic hillock cells":"85.1","Respiratory basal cells":"108.1","Suprabasal keratinocytes":"110.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"123.9","Basal cells":"108.1","Neuronal cells":"110.4","Suprabasal cells":"110.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"upper rhombic lip":"379.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"21.5","Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"50.3","Head and Neck Squamous Cell Carcinoma (TCGA)":"53.2","Lung Squamous Cell Carcinoma (TCGA)":"29.1"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"cerebellum":"234.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Esophageal cancer":"27.8","Gallbladder cancer":"40.3","head and neck cancer":"50.9"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland basal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"18","RNA mouse brain regional specific nTPM":{"cerebellum":"32.0"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":"58","RNA pig brain regional specific nTPM":{"cerebellum":"313.3"},"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1540827.9","Keratinocytes":"6012186.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3923","Protein tissue specific Intensity":{"salivary gland":"304514.9","Stomach":"480101.4"},"Antibody":["CAB033680","HPA044656"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"250000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB033680":null,"HPA044656":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":8,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA023677":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.00e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.87e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"}},{"Gene":"FBLL1","Gene synonym":["LOC345630"],"Ensembl":"ENSG00000188573","Gene description":"Fibrillarin like 1","Uniprot":["A6NHQ2"],"Chromosome":"5","Position":"168529305-168530634","Protein class":["Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":["Methyltransferase","Ribonucleoprotein","RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"41.4","pituitary gland":"17.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"31.9","Brain excitatory neurons":"7.8","Brain inhibitory neurons":"8.9","Corticotrophs":"6.3","Late primary spermatocytes":"6.7","Other brain neurons":"13.7","Pancreatic islet cells":"15.3","Retinal amacrine cells":"5.2","Thyrotrophs":"7.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"31.9","Neuronal cells":"13.7","Pancreatic islet cells":"15.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"9.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Neuroblastoma":"23.6"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":null,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA049546":null,"HPA077724":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"}},{"Gene":"FBN2","Gene synonym":["CCA","DA9"],"Ensembl":"ENSG00000138829","Gene description":"Fibrillin 2","Uniprot":["P35556"],"Chromosome":"5","Position":"128257909-128659185","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"placenta":"63.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"721.7","Cardiomyocytes":"232.1","Cytotrophoblasts":"1452.5","Migrating cytotrophoblasts":"435.8","Pituitary stem cells":"485.1","Syncytiotrophoblasts":"379.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"721.7","Stem cells":"485.1","Trophoblast cells":"1452.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"117.3","midbrain-derived inhibitory":"237.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"2.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"monocytes":"2.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"46.8"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4700000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Primary cilium"],"Antibody RRID":{"CAB026401":null,"HPA012853":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044117":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.21e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"}},{"Gene":"FBXL13","Gene synonym":["CFAP169","DRC6","Fbl13","MGC21636"],"Ensembl":"ENSG00000161040","Gene description":"F-box and leucine rich repeat protein 13","Uniprot":["Q8NEE6"],"Chromosome":"7","Position":"102811189-103074839","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"stomach 1":"4.8","testis":"3.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"267.6","Ependymal cells":"459.4","Epicardial cells":"293.4","Fallopian tube ciliated cells":"328.2","Late spermatids":"747.8","Mucous neck cells":"243.6","Neutrophils":"625.4","Respiratory ciliated cells":"467.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"467.8","Neutrophils":"625.4","Spermatogenic cell types":"747.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"495.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"51","RNA blood cell specific nTPM":{"eosinophil":"14.8","neutrophil":"56.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"148","RNA blood lineage specific nTPM":{"granulocytes":"56.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057232":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FBXL14","Gene synonym":["Fbl14","MGC40195"],"Ensembl":"ENSG00000171823","Gene description":"F-box and leucine rich repeat protein 14","Uniprot":["Q8N1E6"],"Chromosome":"12","Position":"1565993-1594581","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"93.2","Late spermatids":"129.9","Pancreatic duct cells":"78.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"129.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053889":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"FBXL16","Gene synonym":["C16orf22","Fbl16","MGC33974"],"Ensembl":"ENSG00000127585","Gene description":"F-box and leucine rich repeat protein 16","Uniprot":["Q8N461"],"Chromosome":"16","Position":"692498-705808","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"17","RNA tissue specific nTPM":{"brain":"504.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"37.8","Brain inhibitory neurons":"46.3","Corticotrophs":"19.0","Esophageal apical cells":"27.8","Lactotrophs":"17.2","Other brain neurons":"24.1","Retinal amacrine cells":"22.4","Retinal bipolar cells":"33.2","Retinal horizontal cells":"24.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"27.8","Neuronal cells":"46.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"22.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"32.1"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039504":null,"HPA056354":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.17e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.64e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.87e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.82e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FBXL2","Gene synonym":["FBL2","FBL3"],"Ensembl":"ENSG00000153558","Gene description":"F-box and leucine rich repeat protein 2","Uniprot":["Q9UKC9"],"Chromosome":"3","Position":"33277025-33403662","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["Calmodulin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"312.3","Endometrial ciliated cells":"347.1","Ependymal cells":"316.1","Epididymal efferent duct ciliated cells":"282.5","Respiratory ciliated cells":"331.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"347.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"14374","Protein tissue specific Intensity":{"cerebral cortex":"1437439.9"},"Antibody":["HPA003240","HPA061783"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":20,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA003240":null,"HPA061783":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"}},{"Gene":"FBXO10","Gene synonym":["FBX10"],"Ensembl":"ENSG00000147912","Gene description":"F-box protein 10","Uniprot":["Q9UK96"],"Chromosome":"9","Position":"37510892-37576380","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Apoptosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"27.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"36.0","Epididymal principal cells":"9.7","Gonadotrophs":"12.9","Late primary spermatocytes":"9.8","Late spermatids":"42.2","Tuft cells":"11.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"42.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"2.1","naive B-cell":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"2.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":3,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA002863":null,"HPA072721":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.81e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"}},{"Gene":"FBXO15","Gene synonym":["FBX15","MGC39671"],"Ensembl":"ENSG00000141665","Gene description":"F-box protein 15","Uniprot":["Q8NCQ5"],"Chromosome":"18","Position":"74073353-74147843","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"3.8","testis":"7.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"59.9","Endometrial ciliated cells":"66.3","Ependymal cells":"233.3","Epididymal efferent duct ciliated cells":"81.8","Fallopian tube ciliated cells":"85.2","Late primary spermatocytes":"71.0","Respiratory ciliated cells":"143.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"233.3","Spermatogenic cell types":"71.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"237.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"1.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"T-cells":"1.6"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"FBXO16","Gene synonym":["FBX16"],"Ensembl":"ENSG00000214050","Gene description":"F-box protein 16","Uniprot":["Q8IX29"],"Chromosome":"8","Position":"28348287-28490278","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"17.3","pituitary gland":"16.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"111.8","Corticotrophs":"226.9","Epididymal principal cells":"141.0","Gonadotrophs":"221.7","Lactotrophs":"264.6","Rod photoreceptor cells":"193.7","Somatotrophs":"275.1","Thyrotrophs":"222.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"193.7","Pituitary endocrine cells":"275.1","Reproductive supporting cells":"141.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"plasmacytoid DC":"8.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"dendritic cells":"8.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Prostate - Prostate glandular cells","Skin - Outer root sheath cells","Spleen - Plasma cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"3303","Protein cell type specific Intensity":{"Fallopian tube cells":"397150.5","Pancreas epithelial cells":"263416.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"731","Protein tissue specific Intensity":{"fallopian tube":"73119.9"},"Antibody":["HPA058676","HPA076472"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":9,"Subcellular main location":["Nucleoplasm","Vesicles","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA058676":null,"HPA076472":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"FBXO25","Gene synonym":["FBX25"],"Ensembl":"ENSG00000147364","Gene description":"F-box protein 25","Uniprot":["Q8TCJ0"],"Chromosome":"8","Position":"406428-477967","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"91.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"317.5","Early spermatids":"536.1","Late primary spermatocytes":"1195.1","Late spermatids":"375.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1195.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7630","Protein cell type specific Intensity":{"Skeletal myofibers":"763002.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.06e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.73e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA046657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.72e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"}},{"Gene":"FBXO36","Gene synonym":["Fbx36","FLJ37592"],"Ensembl":"ENSG00000153832","Gene description":"F-box protein 36","Uniprot":["Q8NEA4"],"Chromosome":"2","Position":"229922302-230013119","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"113.9","Endometrial ciliated cells":"101.7","Ependymal cells":"117.5","Fallopian tube ciliated cells":"105.1","Late primary spermatocytes":"176.8","Respiratory ciliated cells":"172.4","Rod photoreceptor cells":"94.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"172.4","Neuronal cells":"113.9","Spermatogenic cell types":"176.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"20.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA053865":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.83e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"}},{"Gene":"FBXO43","Gene synonym":["Fbx43"],"Ensembl":"ENSG00000156509","Gene description":"F-box protein 43","Uniprot":["Q4G163"],"Chromosome":"8","Position":"100133351-100145817","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Meiosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"3.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"38.8","Early spermatids":"9.7","Late primary spermatocytes":"41.1","Late spermatids":"10.8","Megakaryocyte progenitors":"12.4","Monocyte progenitors":"12.2","Neutrophil progenitors":"10.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"12.4","Mononuclear phagocytes":"12.2","Neutrophils":"10.8","Spermatogenic cell types":"41.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"5.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"cerebral cortex":"1.3"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024292","HPA024295","HPA024824"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":37,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA040730":null,"HPA075467":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.87e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.25e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.61e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.16e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"}},{"Gene":"FBXO7","Gene synonym":["Fbx","FBX7","PARK15"],"Ensembl":"ENSG00000100225","Gene description":"F-box protein 7","Uniprot":["Q9Y3I1"],"Chromosome":"22","Position":"32474676-32498829","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant","Neurodegeneration","Parkinson disease","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"263.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"332.1","Erythrocytes":"347.7","Late spermatids":"1098.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1098.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"310000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":99,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB034296":null,"HPA032113":null,"HPA032114":null,"HPA057352":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.53e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.97e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"}},{"Gene":"FBXW10","Gene synonym":["C17orf1","C17orf1A","Fbw10","HREP","SM2SH2"],"Ensembl":"ENSG00000171931","Gene description":"F-box and WD repeat domain containing 10","Uniprot":["Q5XX13"],"Chromosome":"17","Position":"18744026-18779349","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"9.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"62.8","Late primary spermatocytes":"30.6","Late spermatids":"19.8","Respiratory ciliated cells":"9.1","Retinal ganglion cells":"7.7","Tuft cells":"11.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"62.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"3.7","liver cancer":"1.6"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA013332":null,"HPA047457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.87e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.49e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.22e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"FCAMR","Gene synonym":["CD351","FCA\/MR","Fcalpha\/muR","FKSG87"],"Ensembl":"ENSG00000162897","Gene description":"Fc alpha and mu receptor","Uniprot":["Q8WWV6"],"Chromosome":"1","Position":"206957965-206970625","Protein class":["CD markers","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"kidney":"35.6","lymphoid tissue":"24.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Paneth cells":"3.9","Proximal tubule cells":"10.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Renal nephron cells":"10.9","Secretory gland support":"3.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"20.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1500000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056505":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FCRL3","Gene synonym":["CD307c","FCRH3","IFGP3","IRTA3","SPAP2","SPAP2a","SPAP2b","SPAP2c","SPAP2d","SPAP2e"],"Ensembl":"ENSG00000160856","Gene description":"Fc receptor like 3","Uniprot":["Q96P31"],"Chromosome":"1","Position":"157674321-157700769","Protein class":["CD markers","Disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Fertilization"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"lymphoid tissue":"46.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"54.9","Early spermatids":"10.1","Hepatic stellate cells":"6.5","Late primary spermatocytes":"4.8","Late spermatids":"15.5","NK-cells":"47.1","T-cells":"10.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"54.9","NK-cells":"47.1","Spermatogenic cell types":"15.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"63","RNA single nuclei brain specific nCPM":{"leukocyte":"33.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"35.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"54","RNA blood lineage specific nTPM":{"B-cells":"35.4","NK-cells":"20.5","T-cells":"19.1"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"81","RNA cell line specific nTPM":{"lymphoma":"17.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048022":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FCRL5","Gene synonym":["BXMAS1","CD307e","FCRH5","IRTA2"],"Ensembl":"ENSG00000143297","Gene description":"Fc receptor like 5","Uniprot":["Q96RD9"],"Chromosome":"1","Position":"157513377-157552515","Protein class":["CD markers","Disease related genes","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Fertilization"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"lymphoid tissue":"34.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"114.5","Early spermatids":"62.1","Late primary spermatocytes":"38.1","Plasma cells":"350.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"114.5","Plasma cells":"350.1","Spermatogenic cell types":"62.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"18","RNA single nuclei brain specific nCPM":{"leukocyte":"6.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"17","RNA blood cell specific nTPM":{"memory B-cell":"13.0","naive B-cell":"14.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"B-cells":"14.2"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"12","RNA cell line specific nTPM":{"lymphoma":"20.4","Myeloma":"7.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":169000000,"Blood concentration - Conc. blood MS [pg\/L]":"12000000","Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.47e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.64e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":3,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039012":null,"HPA061375":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"}},{"Gene":"FEM1B","Gene synonym":[],"Ensembl":"ENSG00000169018","Gene description":"Fem-1 homolog B","Uniprot":["Q9UK73"],"Chromosome":"15","Position":"68277745-68295862","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"899.5","Late primary spermatocytes":"377.8","Late spermatids":"364.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"899.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":28,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA041920":null,"HPA042192":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.73e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.69e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"}},{"Gene":"FEM1C","Gene synonym":["EUROIMAGE686608","EUROIMAGE783647","FEM1A","KIAA1785"],"Ensembl":"ENSG00000145780","Gene description":"Fem-1 homolog C","Uniprot":["Q96JP0"],"Chromosome":"5","Position":"115520908-115544775","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"59.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"146.7","Neutrophil progenitors":"122.2","Neutrophils":"149.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA059919":null,"HPA060977":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"}},{"Gene":"FER1L5","Gene synonym":["DKFZp434I0121"],"Ensembl":"ENSG00000249715","Gene description":"Fer-1 like family member 5","Uniprot":["A0AVI2"],"Chromosome":"2","Position":"96642737-96704887","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"4.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"28.1","Early spermatids":"102.6","Ependymal cells":"27.0","Late primary spermatocytes":"62.3","Pituicytes\/FSCs":"32.8","Renal collecting duct principal cells":"20.0","Renal connecting tubule cells":"19.4","Respiratory ciliated cells":"18.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"28.1","Glial cells":"32.8","Spermatogenic cell types":"102.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"7603","Protein tissue specific Intensity":{"heart muscle":"426754.7","kidney":"1105708.2","liver":"748559.2"},"Antibody":["HPA049568"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA049568":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FER1L6","Gene synonym":["C8ORFK23"],"Ensembl":"ENSG00000214814","Gene description":"Fer-1 like family member 6","Uniprot":["Q2WGJ9"],"Chromosome":"8","Position":"123851987-124120061","Protein class":["Plasma proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"stomach 1":"40.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Foveolar cells":"1012.8","Goblet cells":"1164.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Gastric glandular cells":"1012.8","Goblet cells":"1164.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"38.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"5.9","Stomach Adenocarcinoma (TCGA)":"7.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"1.5","pancreatic cancer":"2.0"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Cytosol"],"Antibody RRID":{"HPA054117":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FETUB","Gene synonym":[],"Ensembl":"ENSG00000090512","Gene description":"Fetuin B","Uniprot":["Q9UGM5"],"Chromosome":"3","Position":"186635969-186653141","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Fertilization"],"Molecular function":["Metalloenzyme inhibitor","Metalloprotease inhibitor","Protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"27","RNA tissue specific nTPM":{"liver":"219.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Esophageal apical cells":"70.4","Hepatocytes":"55.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"70.4","Hepatocytes":"55.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"44.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Ascending Loop of Henle cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"234308.2"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035132","HPA035133"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":"Secreted to blood","Secretome function":"Enzyme inhibitor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":47500000000,"Blood concentration - Conc. blood MS [pg\/L]":"2500000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":6,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035132":null,"HPA035133":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FEZF1","Gene synonym":["ZNF312B"],"Ensembl":"ENSG00000128610","Gene description":"FEZ family zinc finger 1","Uniprot":["A0PJY2"],"Chromosome":"7","Position":"122301303-122310691","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding","Repressor"],"Disease involvement":["Disease variant","Hypogonadotropic hypogonadism","Kallmann syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.1","pituitary gland":"3.0","testis":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"35.9","Late primary spermatocytes":"20.1","Oocytes":"4.6","Other brain neurons":"3.4","Pituicytes\/FSCs":"9.2","Retinal bipolar cells":"6.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"9.2","Proliferating cells":"35.9","Spermatogenic cell types":"20.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"amygdala excitatory":"1.4","astrocyte":"1.8","ependymal cell":"1.4","splatter":"1.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"38","RNA brain regional specific nTPM":{"hypothalamus":"270.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"Bone cancer":"53.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"11","RNA mouse brain regional specific nTPM":{"hypothalamus":"11.7"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"14","RNA pig brain regional specific nTPM":{"hypothalamus":"9.6"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA064639","HPA073693"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA064639":null,"HPA073693":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FGA","Gene synonym":[],"Ensembl":"ENSG00000171560","Gene description":"Fibrinogen alpha chain","Uniprot":["P02671"],"Chromosome":"4","Position":"154583126-154590742","Protein class":["Cancer-related genes","Candidate cardiovascular disease genes","Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted secreted proteins"],"Biological process":["Adaptive immunity","Blood coagulation","Hemostasis","Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":["Amyloidosis","Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"384","RNA tissue specific nTPM":{"liver":"17201.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"44","RNA single cell type specific nCPM":{"Hepatocytes":"17123.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"44","RNA single cell type group specific nCPM":{"Hepatocytes":"17123.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"21","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"5313.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"liver cancer":"180.5"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Stomach - Parietal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"801939120.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB016776","HPA051370","HPA064755"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Endoplasmic reticulum"],"Secretome location":"Secreted to blood","Secretome function":"Blood coagulation","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":407000000,"Blood concentration - Conc. blood MS [pg\/L]":"210000000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 53: Liver - Plasma proteins","Brain expression cluster":null,"Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":15,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB016776":null,"HPA051370":null,"HPA064755":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"}},{"Gene":"FGD3","Gene synonym":["FLJ00004","ZFYVE5"],"Ensembl":"ENSG00000127084","Gene description":"FYVE, RhoGEF and PH domain containing 3","Uniprot":["Q5JSP0"],"Chromosome":"9","Position":"92947523-93036236","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"37.3","lymphoid tissue":"32.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"113.5","Late spermatids":"227.5","Microglia":"84.4","Neutrophil progenitors":"217.7","Neutrophils":"683.2","NK-cells":"136.2","Oocytes":"87.5","T-cells":"113.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"683.2","Spermatogenic cell types":"227.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"102.0","leukocyte":"187.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"27.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"23.9"},"RNA tissue cell type enrichment":["Pituitary gland - T-cells","Prostate - T-cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"12825055.7","Neutrophils":"15123572.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"5643545.8"},"Antibody":["HPA020963","HPA021018"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4400","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":2,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020963":null,"HPA021018":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-7"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"}},{"Gene":"FGD4","Gene synonym":["CMT4H","frabin","FRABP","ZFYVE6"],"Ensembl":"ENSG00000139132","Gene description":"FYVE, RhoGEF and PH domain containing 4","Uniprot":["Q96M96"],"Chromosome":"12","Position":"32399558-32646050","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding","Guanine-nucleotide releasing factor"],"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"monocytes":"1393.7","Neutrophil progenitors":"1727.6","Neutrophils":"4466.3","Rod photoreceptor cells":"1140.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"4466.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1071.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"35.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"classical monocyte":"3.5","eosinophil":"8.2","intermediate monocyte":"5.8","myeloid DC":"3.4","neutrophil":"5.2","non-classical monocyte":"5.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"3.4","granulocytes":"8.2","monocytes":"5.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Parietal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039235"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Actin filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":null,"Subcellular main location":["Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA039235":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"}},{"Gene":"FGF14","Gene synonym":["FHF4","SCA27"],"Ensembl":"ENSG00000102466","Gene description":"Fibroblast growth factor 14","Uniprot":["Q92915"],"Chromosome":"13","Position":"101710804-102402457","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"9.6","cervix":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"1489.2","Bergmann glia":"4868.1","Brain excitatory neurons":"2868.2","Brain inhibitory neurons":"2907.9","Ependymal cells":"863.3","Oligodendrocyte progenitor cells":"2827.5","Other brain neurons":"1401.8","Respiratory ciliated cells":"854.5","Retinal horizontal cells":"855.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"1489.2","Glial cells":"4868.1","Neuronal cells":"2907.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"5.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.2","Neuroblastoma":"4.0"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adrenal gland - Adrenal medulla cells","Prostate - Fibroblasts","Skeletal muscle - Fibroblasts","Spleen - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049828"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":2,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA049828":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FGL1","Gene synonym":["HFREP-1","HPS"],"Ensembl":"ENSG00000104760","Gene description":"Fibrinogen like 1","Uniprot":["Q08830"],"Chromosome":"8","Position":"17864380-17910365","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"liver":"3863.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Hepatocytes":"7991.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Hepatocytes":"7991.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"165.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"20","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"1379.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Gastric cancer":"14.9","liver cancer":"57.2"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"4934497.4","Pancreatic islets":"1926565.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"15973261.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Immunity","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":33700000,"Blood concentration - Conc. blood MS [pg\/L]":"250000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"}},{"Gene":"FH","Gene synonym":[],"Ensembl":"ENSG00000091483","Gene description":"Fumarate hydratase","Uniprot":["P07954"],"Chromosome":"1","Position":"241497511-241519799","Protein class":["Cancer-related genes","Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Tricarboxylic acid cycle"],"Molecular function":["Lyase"],"Disease involvement":["Cancer-related genes","Disease variant","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"252.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"196.9","Late primary spermatocytes":"207.8","Syncytiotrophoblasts":"199.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"207.8","Trophoblast cells":"199.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"536593961.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"562463050.0"},"Antibody":["CAB017785","HPA025770","HPA025948","HPA027341","CAB080323"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2300000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":20,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB017785":null,"CAB080323":null,"HPA025770":null,"HPA025948":null,"HPA027341":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.63e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.42e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.52e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"}},{"Gene":"FHAD1","Gene synonym":["KIAA1937"],"Ensembl":"ENSG00000142621","Gene description":"Forkhead associated phosphopeptide binding domain 1","Uniprot":["B1AJZ9"],"Chromosome":"1","Position":"15236521-15400283","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"9.9","fallopian tube":"14.6","testis":"12.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"158.6","Early spermatids":"449.8","Endometrial ciliated cells":"459.5","Ependymal cells":"463.6","Epididymal efferent duct ciliated cells":"417.2","Fallopian tube ciliated cells":"335.5","Late primary spermatocytes":"155.8","Late spermatids":"616.3","Respiratory ciliated cells":"681.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"681.4","Spermatogenic cell types":"616.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"472.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA054284":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"FHDC1","Gene synonym":["INF1","KIAA1727"],"Ensembl":"ENSG00000137460","Gene description":"FH2 domain containing 1","Uniprot":["Q9C0D6"],"Chromosome":"4","Position":"152936323-152979671","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"16.5","thyroid gland":"14.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"110.6","Prostatic glandular cells":"54.8","Syncytiotrophoblasts":"196.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"110.6","Trophoblast cells":"196.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"39.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"8327","Protein cell type specific Intensity":{"Alveolar cell types":"1001591.0","Granulosa cells":"663816.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"3348971.7"},"Antibody":["HPA008527","HPA008603"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Primary cilium","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":null,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA008527":null,"HPA008603":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"FHIP2A","Gene synonym":["bA106M7.3","FAM160B1","KIAA1600"],"Ensembl":"ENSG00000151553","Gene description":"FHF complex subunit HOOK interacting protein 2A","Uniprot":["Q5W0V3"],"Chromosome":"10","Position":"114821744-114899832","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"50.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"141.6","Neutrophils":"160.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"160.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2513340.1"},"Antibody":["HPA043624"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":7,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA043624":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"}},{"Gene":"FHL5","Gene synonym":["ACT","dJ393D12.2","FLJ33049"],"Ensembl":"ENSG00000112214","Gene description":"Four and a half LIM domains 5","Uniprot":["Q5TD97"],"Chromosome":"6","Position":"96562548-96618626","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"blood vessel":"244.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1427.3","Late spermatids":"1946.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1946.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"pericyte":"419.1","vascular associated smooth muscle cell":"579.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"11.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Adrenal gland - Fibroblasts","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Smooth muscle cells","Prostate - Endothelial cells","Skin - Endothelial cells","Stomach - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Smooth muscle cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5224","Protein tissue specific Intensity":{"ovary":"522438.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":68,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.62e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.64e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FIBP","Gene synonym":["FGFIBP"],"Ensembl":"ENSG00000172500","Gene description":"FGF1 intracellular binding protein","Uniprot":["O43427"],"Chromosome":"11","Position":"65883740-65888531","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1043.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1043.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"59000478.5"},"Antibody":["HPA011729"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA011729":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.08e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"FICD","Gene synonym":["HIP13","HYPE"],"Ensembl":"ENSG00000198855","Gene description":"FIC domain protein adenylyltransferase","Uniprot":["Q9BVA6"],"Chromosome":"12","Position":"108515277-108525837","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Unfolded protein response"],"Molecular function":["Hydrolase","Nucleotidyltransferase","Transferase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"87.7","Epididymal principal cells":"56.8","Late spermatids":"76.4","Plasma cells":"45.1","Retinal pigment epithelial cells":"72.5","Syncytiotrophoblasts":"46.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pigment cells":"72.5","Reproductive supporting cells":"56.8","Spermatogenic cell types":"87.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"2164213.1","Pancreatic islets":"1592909.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3060","Protein tissue specific Intensity":{"pancreas":"305963.4"},"Antibody":["HPA021390","HPA071134"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA021390":null,"HPA071134":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"FILIP1L","Gene synonym":["DOC-1","GIP130"],"Ensembl":"ENSG00000168386","Gene description":"Filamin A interacting protein 1 like","Uniprot":["Q4L180"],"Chromosome":"3","Position":"99828811-100114513","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"191.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"930.7","Epicardial cells":"1043.8","Late spermatids":"2461.5","Myonuclei":"5255.7","Vascular smooth muscle cells":"638.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"5255.7","Spermatogenic cell types":"2461.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"564.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"3.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"34.9","Rhabdoid":"38.7"},"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Kidney - Fibroblasts","Liver - Hepatic stellate cells","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"7","RNA mouse brain regional specific nTPM":{"olfactory bulb":"18.0"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"73110833.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"9459032.7","Stomach":"8839841.7"},"Antibody":["HPA043133"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA043133":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"FKBP3","Gene synonym":["FKBP-25","FKBP25"],"Ensembl":"ENSG00000100442","Gene description":"FKBP prolyl isomerase 3","Uniprot":["Q00688"],"Chromosome":"14","Position":"45115599-45135319","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase","Rotamase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"397.6","tongue":"347.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"410.8","Late spermatids":"621.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"621.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"275639622.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"238788727.1"},"Antibody":["HPA000864","CAB012232","CAB012520"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"460000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":15,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB012232":null,"CAB012520":null,"HPA000864":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.90e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"}},{"Gene":"FKBP4","Gene synonym":["FKBP52","FKBP59"],"Ensembl":"ENSG00000004478","Gene description":"FKBP prolyl isomerase 4","Uniprot":["Q02790"],"Chromosome":"12","Position":"2794970-2805423","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Isomerase","Rotamase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"260.5","Esophageal apical cells":"252.2","Esophageal basal cells":"242.0","Esophageal suprabasal cells":"243.2","Late primary spermatocytes":"283.0","Migrating cytotrophoblasts":"230.3","Syncytiotrophoblasts":"276.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006148","CAB017441","HPA062857"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"600000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":57,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB017441":null,"HPA006148":null,"HPA062857":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.21e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.18e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.68e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"}},{"Gene":"FKBP6","Gene synonym":["FKBP36","PPIase"],"Ensembl":"ENSG00000077800","Gene description":"FKBP prolyl isomerase family member 6 (inactive)","Uniprot":["O75344"],"Chromosome":"7","Position":"73328161-73358637","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","RNA-mediated gene silencing","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant","Williams-Beuren syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"152","RNA tissue specific nTPM":{"testis":"53.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Differentiating spermatogonia":"33.5","Early primary spermatocytes":"126.1","Early spermatids":"39.3","Late primary spermatocytes":"125.3","Late spermatids":"31.7","Oocytes":"41.4","Undifferentiated spermatogonia":"34.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Oocytes":"41.4","Spermatogenic cell types":"126.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"2.1","oligodendrocyte":"1.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"1.1"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1711","Protein cell type specific Intensity":{"Oocytes":"171137.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041414","HPA061109"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli fibrillar center","Microtubules","Cytokinetic bridge","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":51,"Subcellular main location":["Nucleoli fibrillar center","Cytosol"],"Subcellular additional location":["Microtubules","Cytokinetic bridge"],"Antibody RRID":{"HPA041414":null,"HPA061109":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FKBP7","Gene synonym":["FKBP23"],"Ensembl":"ENSG00000079150","Gene description":"FKBP prolyl isomerase 7","Uniprot":["Q9Y680"],"Chromosome":"2","Position":"178463664-178478600","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase","Rotamase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"52.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"168.2","Early spermatids":"259.3","Fibroblasts":"52.8","Hepatic stellate cells":"58.1","Late primary spermatocytes":"76.0","Late spermatids":"65.1","Leydig cells":"53.6","Ovarian stromal cells":"88.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"259.3","Stromal cells":"168.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Adrenal gland - Fibroblasts","Breast - Fibroblasts","Kidney - Fibroblasts","Prostate - Fibroblasts","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"10711758.1","Oocytes":"18016949.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"77722406.2"},"Antibody":["HPA008707"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":61,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA008707":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.67e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"}},{"Gene":"FLACC1","Gene synonym":["ALS2CR12"],"Ensembl":"ENSG00000155749","Gene description":"Flagellum associated containing coiled-coil domains 1","Uniprot":["Q96Q35"],"Chromosome":"2","Position":"201288271-201357398","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"8.5","testis":"16.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"66.7","Choroid plexus epithelial cells":"88.8","Early spermatids":"101.3","Ependymal cells":"168.9","Epididymal efferent duct ciliated cells":"87.3","Fallopian tube ciliated cells":"64.3","Late primary spermatocytes":"124.3","Respiratory ciliated cells":"146.9","Retinal bipolar cells":"61.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"168.9","Myocytes":"66.7","Neuronal cells":"61.2","Spermatogenic cell types":"124.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"180.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"3.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7891","Protein tissue specific Intensity":{"skeletal muscle":"789056.3"},"Antibody":["HPA035793"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol","Connecting piece","Mid piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":9,"Subcellular main location":["Cytosol","Connecting piece","Mid piece","Annulus"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA035793":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"}},{"Gene":"FLAD1","Gene synonym":["FAD1","PP591"],"Ensembl":"ENSG00000160688","Gene description":"Flavin adenine dinucleotide synthetase 1","Uniprot":["Q8NFF5"],"Chromosome":"1","Position":"154983338-154993111","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"126.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"126.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":9,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Cytokinetic bridge","Primary cilium","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA028476":null,"HPA028486":null,"HPA028563":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"}},{"Gene":"FLII","Gene synonym":["FLI","Fli1","FLIL","MGC39265"],"Ensembl":"ENSG00000177731","Gene description":"FLII actin remodeling protein","Uniprot":["Q13045"],"Chromosome":"17","Position":"18244815-18258738","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Actin-binding","Activator"],"Disease involvement":["Cardiomyopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"239.7"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA007084","HPA008903","CAB016132"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":40,"Subcellular main location":["Nucleoplasm","Centriolar satellite","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB016132":null,"HPA007084":null,"HPA008903":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.11e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"}},{"Gene":"FLT1","Gene synonym":["FLT","VEGFR1"],"Ensembl":"ENSG00000102755","Gene description":"Fms related receptor tyrosine kinase 1","Uniprot":["P17948"],"Chromosome":"13","Position":"28300346-28495145","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Plasma proteins","Predicted membrane proteins","Predicted secreted proteins","RAS pathway related proteins"],"Biological process":["Angiogenesis","Chemotaxis","Differentiation"],"Molecular function":["Developmental protein","Kinase","Receptor","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"placenta":"394.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"308.8","Extravillous trophoblasts":"1644.7","Late spermatids":"279.5","Migrating cytotrophoblasts":"449.7","M\u00fcller glia":"545.6","Neutrophils":"284.2","Syncytiotrophoblasts":"1703.8","Vascular endothelial cells":"1218.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Endothelial cells":"1218.5","Glial cells":"545.6","Trophoblast cells":"1703.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"12","RNA single nuclei brain specific nCPM":{"endothelial cell":"3142.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"123.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"15.1","testis cancer":"39.8"},"RNA tissue cell type enrichment":["Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Liver - Vascular endothelial cells","Minor Salivary Gland - Endothelial cells","Pituitary gland - Endothelial cells","Prostate - Endothelial cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"17418439.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1602","Protein tissue specific Intensity":{"skeletal muscle":"160212.6"},"Antibody":["HPA011740","HPA014290","CAB068189","CAB068190"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Actin filaments","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"Receptor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":876000,"Blood concentration - Conc. blood MS [pg\/L]":"300000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":21,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Actin filaments","Cytosol"],"Antibody RRID":{"CAB068189":null,"CAB068190":null,"HPA011740":null,"HPA014290":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.90e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.13e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"}},{"Gene":"FMC1","Gene synonym":["C7orf55","HSPC268"],"Ensembl":"ENSG00000164898","Gene description":"Formation of mitochondrial complex V assembly factor 1 homolog","Uniprot":["Q96HJ9"],"Chromosome":"7","Position":"139339457-139346328","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"559.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"559.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"17360835.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045663","HPA050553"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA045663":null,"HPA050553":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.43e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.40e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.39e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"}},{"Gene":"FMN1","Gene synonym":["DKFZP686C2281","FLJ45135","FMN","LD","MGC125288","MGC125289"],"Ensembl":"ENSG00000248905","Gene description":"Formin 1","Uniprot":["Q68DA7"],"Chromosome":"15","Position":"32765544-33194714","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"27.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"1531.9","Distal convoluted tubule cells":"817.3","Lactotrophs":"412.1","Macrophages":"547.7","Melanocytes":"970.4","Microglia":"316.0","monocytes":"500.9","Retinal bipolar cells":"702.3","Retinal ganglion cells":"332.2","Rod photoreceptor cells":"358.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"547.7","Neuronal cells":"1531.9","Pigment cells":"970.4","Renal nephron cells":"817.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"52.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"skin cancer":"45.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Adrenal gland - Macrophages","Heart muscle - Macrophages","Pituitary gland - Lactotropes","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"784290.3","Fallopian tube cells":"1590200.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"33","Protein tissue specific Intensity":{"fallopian tube":"3292.1"},"Antibody":["HPA005465","HPA046786"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA005465":null,"HPA046786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.16e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"}},{"Gene":"FMO5","Gene synonym":[],"Ensembl":"ENSG00000131781","Gene description":"Flavin containing dimethylaniline monoxygenase 5","Uniprot":["P49326"],"Chromosome":"1","Position":"147175351-147243050","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"638.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"234.4","Cardiomyocytes":"237.9","Cholangiocytes":"220.6","Enterocytes":"163.2","Gastric chief cells":"214.0","Hepatocytes":"434.2","Lacrimal acinar cells":"152.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"434.2","Myocytes":"237.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"158.3","Lung Adenocarcinoma (TCGA)":"41.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"9.0"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Liver - Hepatocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"180105681.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"194876995.9"},"Antibody":["HPA012373"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":null,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA012373":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":54,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Aggresome"],"Antibody RRID":{"HPA041341":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"FNIP2","Gene synonym":["FNIPL","KIAA1450","MAPO1"],"Ensembl":"ENSG00000052795","Gene description":"Folliculin interacting protein 2","Uniprot":["Q9P278"],"Chromosome":"4","Position":"158769026-158908050","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"452.5","Endometrial glandular cells":"424.9","Macrophages":"530.6","monocytes":"610.2","Renal collecting duct intercalated cells":"426.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"610.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"52.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"intermediate monocyte":"3.3","myeloid DC":"2.1","non-classical monocyte":"7.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"dendritic cells":"2.1","monocytes":"7.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"308538.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"4505377.2"},"Antibody":["HPA042779","HPA052758","HPA072420"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"HPA042779":null,"HPA052758":null,"HPA072420":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.76e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"FOXB1","Gene synonym":["FKH5","HFKH-5"],"Ensembl":"ENSG00000171956","Gene description":"Forkhead box B1","Uniprot":["Q99853"],"Chromosome":"15","Position":"60004234-60061730","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"3.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"10.4","Early spermatids":"18.0","Endometrial ciliated cells":"7.9","Endometrial glandular cells":"5.5","Ependymal cells":"5.8","Fallopian tube ciliated cells":"5.4","Late primary spermatocytes":"36.1","Late spermatids":"6.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"7.9","Glial cells":"10.4","Spermatogenic cell types":"36.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"astrocyte":"26.7","ependymal cell":"18.0","mammillary body":"56.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"T-reg":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"T-cells":"1.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"3.3","prostate cancer":"3.1"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"hypothalamus":"6.6"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA073369"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":5,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA073369":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.82e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.99e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA012836":null,"HPA069839":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"}},{"Gene":"FOXJ1","Gene synonym":["FKHL13","HFH-4","HFH4"],"Ensembl":"ENSG00000129654","Gene description":"Forkhead box J1","Uniprot":["Q92949"],"Chromosome":"17","Position":"76136333-76141245","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Cilium biogenesis\/degradation","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes","Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"70.2","fallopian tube":"50.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"268.0","Ependymal cells":"145.6","Epididymal efferent duct ciliated cells":"287.9","Fallopian tube ciliated cells":"585.9","Respiratory ciliated cells":"276.1","Respiratory deuterosomal cells":"150.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Ciliated cells":"585.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"204.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"118.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"41.4"},"RNA tissue cell type enrichment":["Lung - 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Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.59e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.87e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":57,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA017998":null,"HPA018864":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.98e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.00e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"}},{"Gene":"FOXL2NB","Gene synonym":["C3orf72","FLJ43329"],"Ensembl":"ENSG00000206262","Gene description":"FOXL2 neighbor","Uniprot":["Q6ZUU3"],"Chromosome":"3","Position":"138947217-138953990","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"21.4","ovary":"53.7","parathyroid gland":"30.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"9.2","Endometrial stromal cells":"8.5","Gonadotrophs":"46.4","Granulosa cells":"24.3","Oocytes":"9.2","Ovarian stromal cells":"17.5","Smooth muscle cells":"7.3","Thyrotrophs":"11.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"9.2","Pituitary endocrine cells":"46.4","Reproductive supporting cells":"24.3","Stromal cells":"17.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"17","RNA single nuclei brain specific nCPM":{"endothelial cell":"15.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":null,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA061017":null,"HPA071790":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"}},{"Gene":"FOXM1","Gene synonym":["FKHL16","HFH-11","HNF-3","INS-1","MPHOSPH2","MPP2","TGT3","trident"],"Ensembl":"ENSG00000111206","Gene description":"Forkhead box M1","Uniprot":["Q08050"],"Chromosome":"12","Position":"2857680-2877174","Protein class":["Cancer-related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Cell cycle","DNA damage","DNA repair","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"23.6","lymphoid tissue":"30.0","testis":"20.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enteric transient amplifying cells":"34.1","Epicardial cells":"31.8","Erythrocyte progenitors":"60.9","Esophageal basal cells":"25.8","Late primary spermatocytes":"25.5","Late spermatids":"33.9","Megakaryocyte progenitors":"48.5","Monocyte progenitors":"62.4","Neutrophil progenitors":"31.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"60.9","Megakaryocytes":"48.5","Mononuclear phagocytes":"62.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":39,"Subcellular main location":["Nucleoplasm","Nucleoli","Nucleoli rim"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB017832":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.50e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.03e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.30e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.32e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.18e-5"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":3,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA050018":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"}},{"Gene":"FOXP2","Gene synonym":["CAGH44","SPCH1","TNRC10"],"Ensembl":"ENSG00000128573","Gene description":"Forkhead box P2","Uniprot":["O15409"],"Chromosome":"7","Position":"114086327-114693772","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"17.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Loop of henle epithelial cells":"691.4","Microglia":"864.9","M\u00fcller glia":"619.6","Myonuclei":"1201.1","Myosatellite cells":"538.8","Respiratory basal cells":"696.9","Respiratory ciliated cells":"747.7","Salivary acinar cells":"506.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"1201.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"2928.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000382":null,"HPA000383":null,"HPA001679":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":58,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029154":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"}},{"Gene":"FREM1","Gene synonym":["C9orf143","C9orf145","C9orf154","DKFZp686M16108","FLJ25461","TILRR"],"Ensembl":"ENSG00000164946","Gene description":"FRAS1 related extracellular matrix 1","Uniprot":["Q5H8C1"],"Chromosome":"9","Position":"14737152-14910995","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Developmental protein"],"Disease involvement":["Craniosynostosis","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"34.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"199.1","Distal convoluted tubule cells":"529.0","Early spermatids":"162.0","Ependymal cells":"157.3","Fibro-adipogenic progenitors":"261.5","Hematopoietic stem cells":"182.0","Late spermatids":"202.6","Megakaryocyte progenitors":"213.0","Megakaryocyte-Erythroid progenitors":"508.4","Renal collecting duct intercalated cells":"515.6","Renal collecting duct principal cells":"201.9","Renal connecting tubule cells":"475.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"515.6","Megakaryocytes":"508.4","Renal nephron cells":"529.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"258.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"4.9","Rhabdoid":"5.9"},"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Liver - Hepatic stellate cells","Minor Salivary Gland - Fibroblasts","Skeletal muscle - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"4438668.9","Distal tubules":"13444598.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"44320","Protein tissue specific Intensity":{"kidney":"4431997.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to extracellular matrix","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7100","Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"}},{"Gene":"FRMD3","Gene synonym":["EPB41L4O","MGC20553"],"Ensembl":"ENSG00000172159","Gene description":"FERM domain containing 3","Uniprot":["A2A2Y4"],"Chromosome":"9","Position":"83242990-83538546","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"79.6","skeletal muscle":"76.1","tongue":"69.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"367.7","Corticotrophs":"823.1","Distal convoluted tubule cells":"715.2","Enterocytes":"395.9","Goblet cells":"416.9","Pericytes":"584.5","Platelets":"458.4","Podocytes":"1018.5","Proximal tubule cells":"367.1","Retinal bipolar cells":"1020.4","Retinal horizontal cells":"851.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"1020.4","Pituitary endocrine cells":"823.1","Renal nephron cells":"1018.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"1293.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"50.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"2.0","intermediate monocyte":"3.4","neutrophil":"2.5","non-classical monocyte":"1.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"2.5","monocytes":"3.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Enteric glia cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Endothelial cells","Prostate - Endothelial cells","Skin - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"1636267.4","Cardiomyocytes":"3970982.7","Glomeruli":"1785806.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1402","Protein tissue specific Intensity":{"heart muscle":"137308.1","skeletal muscle":"142997.2"},"Antibody":["HPA017285"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":11,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA017285":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.79e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.46e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.15e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"}},{"Gene":"FRMD4A","Gene synonym":["bA295P9.4","FLJ10210","FRMD4","KIAA1294"],"Ensembl":"ENSG00000151474","Gene description":"FERM domain containing 4A","Uniprot":["Q9P2Q2"],"Chromosome":"10","Position":"13643706-14462142","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"53.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"1054.9","Brain excitatory neurons":"1602.3","Brain inhibitory neurons":"1640.9","Microglia":"6042.4","Oligodendrocytes":"1922.0","Other brain neurons":"1235.5","Retinal amacrine cells":"1094.6","Retinal ganglion cells":"1147.2","Thyrotrophs":"975.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"6042.4","Neuronal cells":"1640.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"8967.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"2.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"2.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Colon - Enteric glia cells","Liver - Vascular endothelial cells","Skeletal muscle - Endothelial cells","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"5235566.0","Oocytes":"4528398.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1783574.7","cerebral cortex":"1285330.8"},"Antibody":["HPA038449"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA038449":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.47e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.81e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.99e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"}},{"Gene":"FRMD5","Gene synonym":["MGC14161"],"Ensembl":"ENSG00000171877","Gene description":"FERM domain containing 5","Uniprot":["Q7Z6J6"],"Chromosome":"15","Position":"43870761-44195271","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"17.5","heart muscle":"43.6","retina":"18.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"625.2","Brain inhibitory neurons":"599.4","M\u00fcller glia":"564.5","Oligodendrocyte progenitor cells":"474.8","Oligodendrocytes":"2998.8","Pituicytes\/FSCs":"956.4","Retinal amacrine cells":"1920.8","Retinal bipolar cells":"458.9","Retinal ganglion cells":"795.7","Retinal pigment epithelial cells":"567.0","Schwann cells":"899.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"2998.8","Neuronal cells":"1920.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"3046.2","oligodendrocyte":"3359.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"15.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Colon - Enteric glia cells","Heart muscle - Cardiomyocytes","Pituitary gland - Undifferentiated cells (Pituitary gland)","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"572367.4","Oocytes":"221261.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"5010","Protein tissue specific Intensity":{"cerebral cortex":"482153.7","heart muscle":"519839.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.16e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.11e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.28e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"}},{"Gene":"FRMD6","Gene synonym":["C14orf31","EX1","MGC17921","willin"],"Ensembl":"ENSG00000139926","Gene description":"FERM domain containing 6","Uniprot":["Q96NE9"],"Chromosome":"14","Position":"51489100-51730727","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"452.9","Esophageal apical cells":"568.9","Esophageal basal cells":"263.4","Esophageal suprabasal cells":"537.8","Late spermatids":"769.2","Ocular epithelial cells":"333.2","Prostatic hillock cells":"406.9","Suprabasal keratinocytes":"604.3","Urothelial cells":"430.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"568.9","Barrier epithelial cells":"430.5","Basal cells":"452.9","Spermatogenic cell types":"769.2","Suprabasal cells":"604.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"617.3","pericyte":"346.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"1045782.0","Macrophages":"1807517.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"4732.4","intestine":"12160.5","lymphoid tissue":"8662.9"},"Antibody":["HPA001297"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":28,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA001297":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.82e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.56e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.04e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"FRMPD2","Gene synonym":["MGC35285","PDZD5C","PDZK5C"],"Ensembl":"ENSG00000170324","Gene description":"FERM and PDZ domain containing 2","Uniprot":["Q68DX3"],"Chromosome":"10","Position":"48153088-48274696","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"retina":"22.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"115.8","Bergmann glia":"130.1","Choroid plexus epithelial cells":"123.3","Cone photoreceptor cells":"399.5","Endometrial ciliated cells":"316.9","Ependymal cells":"553.8","Epididymal efferent duct ciliated cells":"170.4","Fallopian tube ciliated cells":"104.5","Late spermatids":"86.8","Respiratory ciliated cells":"231.9","Retinal bipolar cells":"121.0","Rod photoreceptor cells":"217.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"553.8","Glial cells":"130.1","Neuronal cells":"399.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"180.6","Bergmann glia":"148.4","ependymal cell":"612.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"prostate cancer":"2.5"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Kidney - Ascending Loop of Henle cells","Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3416","Protein cell type specific Intensity":{"Fallopian tube cells":"341563.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"176","Protein tissue specific Intensity":{"fallopian tube":"17593.9"},"Antibody":["HPA046389","HPA052208"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA046389":null,"HPA052208":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FSCB","Gene synonym":["C14orf155","DKFZP434F1017"],"Ensembl":"ENSG00000189139","Gene description":"Fibrous sheath CABYR binding protein","Uniprot":["Q5H9T9"],"Chromosome":"14","Position":"44504149-44507283","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"288","RNA tissue specific nTPM":{"testis":"28.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"341.3","Late spermatids":"1312.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"161","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1312.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"choroid plexus":"2.5","white matter":"1.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003546"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Flagellar centriole","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA003546":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FSD1L","Gene synonym":["CCDC10","CSDUFD1","FSD1CL","FSD1NL"],"Ensembl":"ENSG00000106701","Gene description":"Fibronectin type III and SPRY domain containing 1 like","Uniprot":["Q9BXM9"],"Chromosome":"9","Position":"105447796-105552433","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"40.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"848.7","Ependymal cells":"214.1","Gonadotrophs":"233.0","Rod photoreceptor cells":"308.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"848.7","Pituitary endocrine cells":"233.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Prostate - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"8465862.4","Fallopian tube cells":"2729712.0","Large ducts":"4271908.6","Microglia and Neuropil":"7362261.8","Neurons":"5191847.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"19937521.5","intestine":"10844250.5"},"Antibody":["HPA035138"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Golgi apparatus","Vesicles"],"Antibody RRID":{"HPA035138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"}},{"Gene":"FSIP1","Gene synonym":["FLJ35989"],"Ensembl":"ENSG00000150667","Gene description":"Fibrous sheath interacting protein 1","Uniprot":["Q8NA03"],"Chromosome":"15","Position":"39588357-39782841","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"intestine":"10.3","testis":"6.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"234.9","Epicardial cells":"666.3","Platelets":"139.2","Salivary myoepithelial cells":"175.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"666.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"264.3"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"16.2","Colon Adenocarcinoma (TCGA)":"9.6","Rectum Adenocarcinoma (TCGA)":"5.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"4.0"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoplasm","Flagellar centriole","Annulus"],"Subcellular additional location":null,"Antibody RRID":{"HPA041002":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.92e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FSIP2","Gene synonym":["FLJ34780"],"Ensembl":"ENSG00000188738","Gene description":"Fibrous sheath interacting protein 2","Uniprot":["Q5CZC0"],"Chromosome":"2","Position":"185738804-185833290","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"intestine":"1.3","stomach 1":"2.4","testis":"5.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"83.9","Cardiomyocytes":"187.4","Early spermatids":"220.0","Epicardial cells":"166.0","Foveolar cells":"172.9","Goblet cells":"85.9","Late primary spermatocytes":"396.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"166.0","Gastric glandular cells":"172.9","Myocytes":"187.4","Spermatogenic cell types":"396.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"1.2"},"RNA tissue cell type enrichment":["Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"7","RNA pig brain regional specific nTPM":{"spinal cord":"1.1"},"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"65142.5","Pancreas epithelial cells":"44182.2","T-cells":"37025.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"6492500.7","skin":"7101521.8"},"Antibody":["HPA036139"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle","Primary cilium","Basal body","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":2,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Primary cilium","Basal body","Mid piece"],"Antibody RRID":{"HPA036139":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FTMT","Gene synonym":["MtF"],"Ensembl":"ENSG00000181867","Gene description":"Ferritin mitochondrial","Uniprot":["Q8N4E7"],"Chromosome":"5","Position":"121851882-121852833","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Iron storage"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"486","RNA tissue specific nTPM":{"testis":"48.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"822.4","Late primary spermatocytes":"489.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"342","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"822.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"FUCA1","Gene synonym":[],"Ensembl":"ENSG00000179163","Gene description":"Alpha-L-fucosidase 1","Uniprot":["P04066"],"Chromosome":"1","Position":"23845077-23868290","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Glycosidase","Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"187.6","Cytotrophoblasts":"240.8","Enterocytes":"209.3","Fallopian tube ciliated cells":"173.3","Hofbauer cells":"180.2","Kupffer cells":"250.1","Syncytiotrophoblasts":"250.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"250.1","Trophoblast cells":"250.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Lung - Macrophages","Pancreas - Macrophages","Spleen - Macrophages","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"36024276.8","Pancreatic islets":"34370732.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046542","HPA056371"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"40000000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":5,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA046542":null,"HPA056371":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.91e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"0.00e+0"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.64e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"}},{"Gene":"FUT10","Gene synonym":[],"Ensembl":"ENSG00000172728","Gene description":"Fucosyltransferase 10","Uniprot":["Q6P4F1"],"Chromosome":"8","Position":"33370824-33473146","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"234.4","Late primary spermatocytes":"165.1","Late spermatids":"433.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"433.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm","Endoplasmic reticulum","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA053970":null,"HPA058655":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.51e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"}},{"Gene":"FUT11","Gene synonym":["MGC33202"],"Ensembl":"ENSG00000196968","Gene description":"Fucosyltransferase 11","Uniprot":["Q495W5"],"Chromosome":"10","Position":"73772276-73780251","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"225.5","Esophageal apical cells":"254.1","Late spermatids":"371.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"254.1","Spermatogenic cell types":"371.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1918209.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014033"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear membrane","Golgi apparatus"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"560000","Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":2,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA014033":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.09e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"}},{"Gene":"FXR1","Gene synonym":[],"Ensembl":"ENSG00000114416","Gene description":"FMR1 autosomal homolog 1","Uniprot":["P51114"],"Chromosome":"3","Position":"180868141-180982753","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Myogenesis","Spermatogenesis"],"Molecular function":["Developmental protein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skeletal muscle":"741.3","tongue":"425.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1104.9","Late primary spermatocytes":"869.8","Late spermatids":"2893.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2893.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018246","HPA055475"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":131,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA018246":null,"HPA055475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.29e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.39e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.53e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.58e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.68e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.84e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.49e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"FYB1","Gene synonym":["ADAP","FYB","FYB-120\/130","SLAP-130"],"Ensembl":"ENSG00000082074","Gene description":"FYN binding protein 1","Uniprot":["O15117"],"Chromosome":"5","Position":"39105252-39274528","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"50.1","lymphoid tissue":"105.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Kupffer cells":"865.0","Macrophages":"459.2","Megakaryocyte progenitors":"387.6","Megakaryocytes":"636.7","Microglia":"985.5","monocytes":"698.2","Neutrophil progenitors":"1172.2","Neutrophils":"2831.2","Platelets":"899.6","T-cells":"587.4","Tuft cells":"1798.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"985.5","Mononuclear phagocytes":"865.0","Neutrophils":"2831.2","Platelets":"899.6","Secretory gland support":"1798.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"36","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1253.7","leukocyte":"822.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1680.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"20.1","Leukemia":"33.9"},"RNA tissue cell type enrichment":["Adrenal gland - Macrophages","Breast - T-cells","Prostate - T-cells","Skin - T-cells","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"19892746.8","T-cells":"40603849.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"19400042.8"},"Antibody":["CAB025336","HPA026796","HPA067427"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4400000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":14,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB025336":null,"HPA026796":null,"HPA067427":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"FYB2","Gene synonym":["ARAP","C1orf168","FLJ43208","RP4-758N20.2"],"Ensembl":"ENSG00000187889","Gene description":"FYN binding protein 2","Uniprot":["Q5VWT5"],"Chromosome":"1","Position":"56718789-56819696","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"10.6","fallopian tube":"12.9","liver":"16.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"234.1","Choroid plexus epithelial cells":"943.3","Epididymal clear cells":"381.7","Pituitary stem cells":"284.0","Renal collecting duct intercalated cells":"794.9","Renal collecting duct principal cells":"419.5","Renal connecting tubule cells":"264.6","Respiratory ciliated cells":"372.6","Respiratory ionocytes":"561.4","Respiratory secretory cells":"281.7","Retinal pigment epithelial cells":"567.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"943.3","Ductal cells":"794.9","Ionocytes":"561.4","Pigment cells":"567.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"33","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"702.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"6.3"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"13","RNA brain regional specific nTPM":{"choroid plexus":"31.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Colon enterocytes","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Lung - Respiratory ciliated cells","Pancreas - Alpha cells","Prostate - Prostate glandular cells","Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"hippocampal formation":"2.1"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"365692.1","Fallopian tube cells":"567255.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"745","Protein tissue specific Intensity":{"fallopian tube":"74477.6"},"Antibody":["HPA054923"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Perinuclear theca","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":["Perinuclear theca","Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA054923":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"}},{"Gene":"FZR1","Gene synonym":["CDC20C","CDH1","FZR","FZR2","HCDH","HCDH1","KIAA1242"],"Ensembl":"ENSG00000105325","Gene description":"Fizzy and cell division cycle 20 related 1","Uniprot":["Q9UM11"],"Chromosome":"19","Position":"3506311-3538334","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA repair","Mitosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"93.5","Late primary spermatocytes":"144.7","Late spermatids":"307.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"307.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"880190.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7643","Protein tissue specific Intensity":{"lymphoid tissue":"764254.4"},"Antibody":["HPA043536"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":127,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA043536":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"}},{"Gene":"G2E3","Gene synonym":["FLJ20333","KIAA1333","PHF7B"],"Ensembl":"ENSG00000092140","Gene description":"G2\/M-phase specific E3 ubiquitin protein ligase","Uniprot":["Q7L622"],"Chromosome":"14","Position":"30559158-30620064","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Apoptosis","Ubl conjugation pathway"],"Molecular function":["Developmental protein","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"39.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"1181.9","Late spermatids":"356.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1181.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001601"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":8,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus","Vesicles"],"Antibody RRID":{"HPA001601":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.74e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"}},{"Gene":"G6PC2","Gene synonym":["IGRP"],"Ensembl":"ENSG00000152254","Gene description":"Glucose-6-phosphatase catalytic subunit 2","Uniprot":["Q9NQR9"],"Chromosome":"2","Position":"168901291-168910000","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Gluconeogenesis"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"70","RNA tissue specific nTPM":{"pancreas":"29.1","retina":"11.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oligodendrocyte progenitor cells":"1.2","Pancreatic islet cells":"1.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1.2","Pancreatic islet cells":"1.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"2.2","hippocampal CA4":"2.6","hippocampal dentate gyrus":"3.7","pericyte":"2.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"76","RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"11.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - Beta cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"9353","Protein cell type specific Intensity":{"Pancreatic islets":"935301.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"6471","Protein tissue specific Intensity":{"heart muscle":"647080.4"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GAA","Gene synonym":[],"Ensembl":"ENSG00000171298","Gene description":"Alpha glucosidase","Uniprot":["P10253"],"Chromosome":"17","Position":"80101556-80119881","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosidase","Hydrolase"],"Disease involvement":["Disease variant","FDA approved drug targets","Glycogen storage disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"200.7","Epididymal principal cells":"135.2","Extravillous trophoblasts":"235.6","Kupffer cells":"163.0","Late primary spermatocytes":"142.9","Syncytiotrophoblasts":"198.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"163.0","Trophoblast cells":"235.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"99.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"66.6","eosinophil":"22.9","intermediate monocyte":"50.3","myeloid DC":"39.8","neutrophil":"27.1","non-classical monocyte":"69.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"dendritic cells":"39.8","granulocytes":"27.1","monocytes":"69.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Macrophages","Spleen - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"59317097.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"392801304.6"},"Antibody":["HPA026970","HPA029126"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5200000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":38,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA026970":null,"HPA029126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"}},{"Gene":"GAB4","Gene synonym":[],"Ensembl":"ENSG00000215568","Gene description":"GRB2 associated binding protein family member 4","Uniprot":["Q2WGN9"],"Chromosome":"22","Position":"16961936-17008222","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"1.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"3.8","Early spermatids":"9.2","Late primary spermatocytes":"10.9","Late spermatids":"42.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"36","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"42.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GABARAP","Gene synonym":["ATG8A","MM46"],"Ensembl":"ENSG00000170296","Gene description":"GABA type A receptor-associated protein","Uniprot":["O95166"],"Chromosome":"17","Position":"7240008-7242449","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Apoptosis","Autophagy","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"268.2","Enteric stem cells":"212.7","Enteric transient amplifying cells":"204.7","Enterocytes":"334.8","Epididymal clear cells":"185.8","Epididymal efferent duct absorptive cells":"205.6","Epididymal efferent duct ciliated cells":"207.3","Epididymal principal cells":"235.3","Gastric chief cells":"340.7","Goblet cells":"247.0","Mucous neck cells":"185.2","Neuroendocrine cells":"252.7","Parietal cells":"371.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"334.8","Gastric glandular cells":"371.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA065883"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":105,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA065883":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.78e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"GABRA1","Gene synonym":["EJM5"],"Ensembl":"ENSG00000022355","Gene description":"Gamma-aminobutyric acid type A receptor subunit alpha1","Uniprot":["P14867"],"Chromosome":"5","Position":"161847063-161899981","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"30","RNA tissue specific nTPM":{"brain":"52.4","retina":"16.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Brain excitatory neurons":"184.1","Brain inhibitory neurons":"156.6","Other brain neurons":"71.8","Retinal bipolar cells":"224.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Neuronal cells":"224.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"583.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"breast cancer":"3.7"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Skin - Inner root sheath cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"6249677.5","Microglia and Neuropil":"14913206.4","Neurons":"6970800.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"289166","Protein tissue specific Intensity":{"cerebral cortex":"28916613.5"},"Antibody":["CAB022502","HPA029363","HPA055746"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":14,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB022502":null,"HPA029363":null,"HPA055746":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GABRA4","Gene synonym":[],"Ensembl":"ENSG00000109158","Gene description":"Gamma-aminobutyric acid type A receptor subunit alpha4","Uniprot":["P48169"],"Chromosome":"4","Position":"46918900-46993581","Protein class":["FDA approved drug targets","Predicted membrane proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"9.3","heart muscle":"2.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"36.5","Bergmann glia":"131.4","Brain excitatory neurons":"74.9","Brain inhibitory neurons":"152.5","Cardiomyocytes":"51.5","Corticotrophs":"24.4","Lactotrophs":"57.4","Other brain neurons":"59.3","Thyrotrophs":"35.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Glial cells":"131.4","Myocytes":"51.5","Neuronal cells":"152.5","Pituitary endocrine cells":"57.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Colon - Colon enteroendocrine cells","Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2226","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"115469.6","Microglia and Neuropil":"364534.7","Neurons":"187843.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"10960","Protein tissue specific Intensity":{"cerebral cortex":"1096050.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GALNT3","Gene synonym":["GalNAc-T3","HFTC","HHS"],"Ensembl":"ENSG00000115339","Gene description":"Polypeptide N-acetylgalactosaminyltransferase 3","Uniprot":["Q14435"],"Chromosome":"2","Position":"165747588-165794659","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"stomach 1":"73.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"269.8","Goblet cells":"249.3","Late primary spermatocytes":"248.6","Ocular epithelial cells":"298.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"118.3","leukocyte":"72.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"50.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"34000","Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA007613":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1100000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":9,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":["Nucleoli","Vesicles"],"Antibody RRID":{"HPA008963":null,"HPA009035":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA012638":null,"HPA073461":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GALR1","Gene synonym":["GALNR","GALNR1"],"Ensembl":"ENSG00000166573","Gene description":"Galanin receptor 1","Uniprot":["P47211"],"Chromosome":"18","Position":"77249848-77277900","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"1.4","pituitary gland":"1.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Pituitary stem cells":"577.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Stem cells":"577.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"99.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.7","Kidney Chromophobe (TCGA)":"2.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"1.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"hypothalamus":"5.2"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA074584"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA074584":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"40000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":31,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA029386":null,"HPA029387":null,"HPA074882":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.72e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.06e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"}},{"Gene":"GARIN2","Gene synonym":["C14orf54","FAM71D","GARI-L2"],"Ensembl":"ENSG00000172717","Gene description":"Golgi associated RAB2 interactor family member 2","Uniprot":["Q8N9W8"],"Chromosome":"14","Position":"67189393-67228550","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"26","RNA tissue specific nTPM":{"testis":"22.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"311.7","Late spermatids":"432.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"26","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"432.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"1.5"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GAS2","Gene synonym":[],"Ensembl":"ENSG00000148935","Gene description":"Growth arrest specific 2","Uniprot":["O43903"],"Chromosome":"11","Position":"22625509-22813001","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Cell cycle","Cell shape","Growth arrest"],"Molecular function":null,"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"37.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"227.0","Gonadotrophs":"461.0","Hepatocytes":"291.4","Myonuclei":"744.7","Retinal ganglion cells":"173.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"291.4","Myocytes":"744.7","Pituitary endocrine cells":"461.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"14.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Myeloma":"64.1"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Pituitary gland - Gonadotropes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"7640843.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"1234735.9","Stomach":"982393.8"},"Antibody":["HPA058904"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA058904":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.42e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"}},{"Gene":"GAS2L3","Gene synonym":[],"Ensembl":"ENSG00000139354","Gene description":"Growth arrest specific 2 like 3","Uniprot":["Q86XJ1"],"Chromosome":"12","Position":"100573683-100628288","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"67.8","Enteric transient amplifying cells":"65.7","Goblet cells":"73.3","Hofbauer cells":"78.2","Macrophages":"104.3","Melanocytes":"54.3","Monocyte progenitors":"66.2","monocytes":"56.3","Schwann cells":"203.6","Syncytiotrophoblasts":"101.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"203.6","Mononuclear phagocytes":"104.3","Trophoblast cells":"101.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"26.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"1.3","myeloid DC":"1.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"1.5","monocytes":"1.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Spleen - Macrophages","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":"4","RNA pig brain regional specific nTPM":{"spinal cord":"18.9"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"227","Protein tissue specific Intensity":{"liver":"22711.2"},"Antibody":["HPA048593"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048593":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.82e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.28e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"}},{"Gene":"GAS8","Gene synonym":["DRC4","GAS11"],"Ensembl":"ENSG00000141013","Gene description":"Growth arrest specific 8","Uniprot":["O95995"],"Chromosome":"16","Position":"90019629-90044975","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"220.7","Fallopian tube ciliated cells":"108.0","Late spermatids":"408.8","Respiratory ciliated cells":"124.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"124.9","Spermatogenic cell types":"408.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"311632","Protein cell type specific Intensity":{"Fallopian tube cells":"31163175.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"68618","Protein tissue specific Intensity":{"fallopian tube":"6861831.3"},"Antibody":["HPA041311","HPA048238"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus","Vesicles","Plasma membrane","Primary cilium","Cytosol","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":99,"Subcellular main location":["Golgi apparatus","Plasma membrane","Primary cilium","Cytosol","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA041311":null,"HPA048238":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.37e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"GBX1","Gene synonym":[],"Ensembl":"ENSG00000164900","Gene description":"Gastrulation brain homeobox 1","Uniprot":["Q14549"],"Chromosome":"7","Position":"151148009-151174745","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"skeletal muscle":"10.6","testis":"7.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early primary spermatocytes":"134.6","Myonuclei":"289.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"23","RNA single cell type group specific nCPM":{"Myocytes":"289.8","Spermatogenic cell types":"134.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"2.1","fibroblast":"2.5","splatter":"3.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055783":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":null,"Protein cell type distribution":null,"Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":null,"Protein tissue distribution":null,"Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB034098","HPA045855","HPA052227"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"CAB034098":null,"HPA045855":null,"HPA052227":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GCNT3","Gene synonym":["C2\/4GnT","C2GnT-M","C2GnT2"],"Ensembl":"ENSG00000140297","Gene description":"Glucosaminyl (N-acetyl) transferase 3, mucin type","Uniprot":["O95395"],"Chromosome":"15","Position":"59594875-59640239","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"gallbladder":"71.0","intestine":"133.9","salivary gland":"54.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"268.9","Conjunctival goblet cells":"133.0","Endometrial glandular cells":"163.2","Endometrial luminal cells":"83.6","Enteric transient amplifying cells":"68.5","Enterocytes":"179.7","Esophageal apical cells":"146.9","Foveolar cells":"82.9","Gastric progenitor cells":"85.9","Oocytes":"87.5","Papillary tip epithelial cells":"74.2","Renal collecting duct principal cells":"127.4","Salivary acinar cells":"86.8","Salivary duct cells":"113.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"146.9","Ductal cells":"127.4","Enterocytes":"268.9","Glandular cells":"163.2","Goblet cells":"133.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"107.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"52.0","pancreatic cancer":"51.3"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":6,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA011154":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.52e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.09e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"}},{"Gene":"GCSAML","Gene synonym":["C1orf150","FLJ44728"],"Ensembl":"ENSG00000169224","Gene description":"Germinal center associated signaling and motility like","Uniprot":["Q5JQS6"],"Chromosome":"1","Position":"247507058-247577690","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.9","prostate":"5.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"23.8","Hematopoietic stem cells":"44.6","Late primary spermatocytes":"29.9","Mast cells":"228.9","Megakaryocyte progenitors":"66.0","Megakaryocytes":"117.5","Platelets":"82.9","Prostatic glandular cells":"57.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"57.1","Mast cells":"228.9","Megakaryocytes":"117.5","Platelets":"82.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"4.9","upper rhombic lip":"13.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"3.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"670","RNA blood cell specific nTPM":{"basophil":"228.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"670","RNA blood lineage specific nTPM":{"granulocytes":"228.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"13","RNA cell line specific nTPM":{"Leukemia":"24.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA027507":null,"HPA027510":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA054182":null,"HPA063265":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GDF5","Gene synonym":["BMP14","CDMP1"],"Ensembl":"ENSG00000125965","Gene description":"Growth differentiation factor 5","Uniprot":["P43026"],"Chromosome":"20","Position":"35433347-35454746","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Chondrogenesis"],"Molecular function":["Cytokine","Growth factor"],"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"salivary gland":"9.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"3.0","Pituicytes\/FSCs":"10.2","Salivary acinar cells":"11.3","Submucosal glandular cells":"3.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"11.3","Glial cells":"10.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"fibroblast":"15.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"6.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"12.4"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015648":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":9,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA069146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GDPD1","Gene synonym":["FLJ37451","GDE4"],"Ensembl":"ENSG00000153982","Gene description":"Glycerophosphodiester phosphodiesterase domain containing 1","Uniprot":["Q8N9F7"],"Chromosome":"17","Position":"59220467-59275970","Protein class":["Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"11.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"54.3","Brain excitatory neurons":"78.6","Brain inhibitory neurons":"74.7","Early primary spermatocytes":"112.4","Early spermatids":"82.9","Ependymal cells":"55.7","Megakaryocyte-Erythroid progenitors":"71.5","Oligodendrocyte progenitor cells":"58.6","Other brain neurons":"55.2","Retinal ganglion cells":"81.1","Tuft cells":"69.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"71.5","Neuronal cells":"81.1","Spermatogenic cell types":"112.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.58e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.56e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"}},{"Gene":"GDPGP1","Gene synonym":["C15orf58"],"Ensembl":"ENSG00000183208","Gene description":"GDP-D-glucose phosphorylase 1","Uniprot":["Q6ZNW5"],"Chromosome":"15","Position":"90233808-90245811","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor","Hydrolase","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"6.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"4.6","Mesothelial cells":"1.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1.6","Myocytes":"4.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"8747781.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1509883.0","intestine":"2069107.7","kidney":"1816107.1","lymphoid tissue":"544143.4"},"Antibody":["HPA048189","HPA059841"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA048189":null,"HPA059841":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"}},{"Gene":"GEMIN2","Gene synonym":["SIP1"],"Ensembl":"ENSG00000092208","Gene description":"Gem nuclear organelle associated protein 2","Uniprot":["O14893"],"Chromosome":"14","Position":"39114285-39136973","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"58.6","Late spermatids":"64.8","Oocytes":"73.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"73.7","Spermatogenic cell types":"64.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"2235327.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB015426","HPA046570","HPA057114"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":45,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"CAB015426":null,"HPA046570":null,"HPA057114":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.48e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"}},{"Gene":"GEMIN4","Gene synonym":["DKFZP434B131","DKFZP434D174","HC56","HCAP1","HHRF-1","p97"],"Ensembl":"ENSG00000179409","Gene description":"Gem nuclear organelle associated protein 4","Uniprot":["P57678"],"Chromosome":"17","Position":"744421-753999","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"155.1","Late primary spermatocytes":"135.6","Late spermatids":"246.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"246.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"817748.6"},"Antibody":["HPA065699","HPA067891"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":103,"Subcellular main location":["Nuclear bodies","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA065699":null,"HPA067891":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.76e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.15e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"}},{"Gene":"GEMIN6","Gene synonym":["FLJ23459"],"Ensembl":"ENSG00000152147","Gene description":"Gem nuclear organelle associated protein 6","Uniprot":["Q8WXD5"],"Chromosome":"2","Position":"38751534-38785002","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"131.2","Late primary spermatocytes":"286.9","Late spermatids":"60.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"286.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"496118.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"808850.6"},"Antibody":["HPA035726","HPA035727"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":53,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA035726":null,"HPA035727":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.22e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-1"}},{"Gene":"GET1","Gene synonym":["CHD5","WRB"],"Ensembl":"ENSG00000182093","Gene description":"Guided entry of tail-anchored proteins factor 1","Uniprot":["O00258"],"Chromosome":"21","Position":"39377698-39428528","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"135.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"24.1","Bergmann glia":"28.0","Brain excitatory neurons":"43.1","Brain inhibitory neurons":"45.1","Choroid plexus epithelial cells":"64.4","Early spermatids":"40.0","Ependymal cells":"83.9","Late spermatids":"22.1","Oligodendrocyte progenitor cells":"30.4","Oligodendrocytes":"54.7","Other brain neurons":"63.2","Podocytes":"63.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"83.9","Glial cells":"54.7","Neuronal cells":"63.2","Renal nephron cells":"63.2","Spermatogenic cell types":"40.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"5305786.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"3095183.1"},"Antibody":["HPA018527"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":32,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018527":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.28e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"}},{"Gene":"GFI1B","Gene synonym":["ZNF163B"],"Ensembl":"ENSG00000165702","Gene description":"Growth factor independent 1B transcriptional repressor","Uniprot":["Q5VTD9"],"Chromosome":"9","Position":"132944000-132991687","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator","Developmental protein","DNA-binding","Repressor"],"Disease involvement":["Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"bone marrow":"36.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"190.6","Erythrocyte progenitors":"140.5","Late spermatids":"83.8","Megakaryocyte progenitors":"81.1","Megakaryocytes":"327.6","Platelets":"456.8","Tuft cells":"46.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Erythrocytes":"140.5","Megakaryocytes":"327.6","Platelets":"456.8","Spermatogenic cell types":"190.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"19","RNA blood cell specific nTPM":{"basophil":"195.8","eosinophil":"396.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"26","RNA blood lineage specific nTPM":{"granulocytes":"396.6"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"25","RNA cell line specific nTPM":{"Leukemia":"46.9"},"RNA tissue cell type enrichment":["Liver - Erythroid cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2893","Protein tissue specific Intensity":{"bone marrow":"289341.1"},"Antibody":["CAB004420","HPA006291"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":27,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB004420":null,"HPA006291":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GFOD2","Gene synonym":["FLJ23802","MGC11335"],"Ensembl":"ENSG00000141098","Gene description":"Glucose-fructose oxidoreductase domain containing 2","Uniprot":["Q3B7J2"],"Chromosome":"16","Position":"67674531-67719339","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"58.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"111.8","Esophageal apical cells":"429.7","Neutrophil progenitors":"104.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"429.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040939":null,"HPA041112":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.22e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.75e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"}},{"Gene":"GFPT1","Gene synonym":["GFA","GFAT","GFAT1","GFPT"],"Ensembl":"ENSG00000198380","Gene description":"Glutamine--fructose-6-phosphate transaminase 1","Uniprot":["Q06210"],"Chromosome":"2","Position":"69319780-69387250","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Biological rhythms"],"Molecular function":["Aminotransferase","Transferase"],"Disease involvement":["Congenital myasthenic syndrome","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Goblet cells":"461.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"248983423.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"149175280.2","pancreas":"167639165.6"},"Antibody":["HPA047240"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"67000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":7,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA047240":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.38e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"}},{"Gene":"GGA1","Gene synonym":[],"Ensembl":"ENSG00000100083","Gene description":"Golgi associated, gamma adaptin ear containing, ARF binding protein 1","Uniprot":["Q9UJY5"],"Chromosome":"22","Position":"37608725-37633564","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"176.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"171.4","Late primary spermatocytes":"238.7","Late spermatids":"304.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"304.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"9082040.9"},"Antibody":["HPA048280","HPA051016"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":53,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA048280":null,"HPA051016":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.98e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.17e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"}},{"Gene":"GGH","Gene synonym":["GATD10"],"Ensembl":"ENSG00000137563","Gene description":"Gamma-glutamyl hydrolase","Uniprot":["Q92820"],"Chromosome":"8","Position":"63014881-63039407","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"117.3","liver":"176.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"652.2","Differentiating spermatogonia":"176.0","Early spermatids":"531.8","Extravillous trophoblasts":"371.8","Hepatocytes":"214.1","Late primary spermatocytes":"180.3","Late spermatids":"184.8","Migrating cytotrophoblasts":"251.5","Oocytes":"336.2","Syncytiotrophoblasts":"882.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"336.2","Spermatogenic cell types":"531.8","Trophoblast cells":"882.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"plasmacytoid DC":"30.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"30.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"400000000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":114,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"CAB019296":null,"HPA025226":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"}},{"Gene":"GGN","Gene synonym":["FLJ35713","MGC33369"],"Ensembl":"ENSG00000179168","Gene description":"Gametogenetin","Uniprot":["Q86UU5"],"Chromosome":"19","Position":"38384267-38388082","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"33","RNA tissue specific nTPM":{"testis":"90.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"36","RNA single cell type specific nCPM":{"Early spermatids":"536.8","Late primary spermatocytes":"578.2","Late spermatids":"1224.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"57","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1224.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"266","Protein cell type specific Intensity":{"Oocytes":"26631.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA078224"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":15,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA078224":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GGNBP2","Gene synonym":["DIF-3","DIF3","FLJ21230","FLJ22561","LZK1","ZFP403","ZNF403"],"Ensembl":"ENSG00000278311","Gene description":"Gametogenetin binding protein 2","Uniprot":["Q9H3C7"],"Chromosome":"17","Position":"36544912-36589848","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"332.6","Late primary spermatocytes":"577.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"577.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":2,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA018914":null,"HPA073392":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.76e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"}},{"Gene":"GGPS1","Gene synonym":["GGPPS1"],"Ensembl":"ENSG00000152904","Gene description":"Geranylgeranyl diphosphate synthase 1","Uniprot":["O95749"],"Chromosome":"1","Position":"235327350-235344532","Protein class":["Disease related genes","Enzymes","Essential proteins","FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Isoprene biosynthesis","Lipid metabolism"],"Molecular function":["Transferase"],"Disease involvement":["Congenital muscular dystrophy","Deafness","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"197.6","Early spermatids":"117.6","Epicardial cells":"332.0","Late primary spermatocytes":"101.7","Late spermatids":"884.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"332.0","Myocytes":"197.6","Spermatogenic cell types":"884.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"4037374.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029472","HPA050727"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":10,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA029472":null,"HPA050727":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"}},{"Gene":"GGTLC1","Gene synonym":["dJ831C21.1","dJ831C21.2","GGTLA3","GGTLA4"],"Ensembl":"ENSG00000149435","Gene description":"Gamma-glutamyltransferase light chain 1","Uniprot":["Q9BX51"],"Chromosome":"20","Position":"23985050-23988779","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"lung":"31.2","testis":"17.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Alveolar cells type 1":"202.5","Late primary spermatocytes":"85.4","Late spermatids":"226.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"76","RNA single cell type group specific nCPM":{"Alveolar cells":"202.5","Spermatogenic cell types":"226.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"15","RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"30.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7950","Protein cell type specific Intensity":{"Capillaries":"795047.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045635","HPA047534"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045635":null,"HPA047534":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GHITM","Gene synonym":["DERP2","HSPC282","My021","PTD010","TMBIM5"],"Ensembl":"ENSG00000165678","Gene description":"Growth hormone inducible transmembrane protein","Uniprot":["Q9H3K2"],"Chromosome":"10","Position":"84139482-84154841","Protein class":["Predicted membrane proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1201.2","Late spermatids":"3986.8","Parietal cells":"1085.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Gastric glandular cells":"1085.5","Spermatogenic cell types":"3986.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"8826582.9"},"Antibody":["HPA016464","HPA061664"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":57,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA016464":null,"HPA061664":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.08e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"}},{"Gene":"GID4","Gene synonym":["C17orf39","VID24"],"Ensembl":"ENSG00000141034","Gene description":"GID complex subunit 4 homolog","Uniprot":["Q8IVV7"],"Chromosome":"17","Position":"18039408-18068405","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"67.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"845.7","Late spermatids":"1672.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1672.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"59.7"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"202234.5","Neurons":"64043.9","Pancreas epithelial cells":"126086.9","Pancreatic islets":"154050.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"13587","Protein tissue specific Intensity":{"cerebral cortex":"1358703.9"},"Antibody":["HPA044348"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":42,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA044348":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.69e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.59e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"}},{"Gene":"GINM1","Gene synonym":["C6orf72","dJ12G14.2"],"Ensembl":"ENSG00000055211","Gene description":"Glycosylated integral membrane protein 1","Uniprot":["Q9NU53"],"Chromosome":"6","Position":"149566294-149591748","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"698.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"698.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"40","Protein cell type specific Intensity":{"Proximal tubules":"3992.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"3446842.2"},"Antibody":["HPA017210","HPA041679"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"89000","Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":["Nucleoli fibrillar center","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA017210":null,"HPA041679":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.49e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"}},{"Gene":"GINS1","Gene synonym":["KIAA0186","PSF1"],"Ensembl":"ENSG00000101003","Gene description":"GINS complex subunit 1","Uniprot":["Q14691"],"Chromosome":"20","Position":"25391008-25452700","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA replication"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"6.8","testis":"8.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"52.3","Early primary spermatocytes":"66.1","Early spermatids":"100.6","Erythrocyte progenitors":"55.9","Late primary spermatocytes":"74.0","Megakaryocyte progenitors":"48.8","Monocyte progenitors":"47.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"55.9","Megakaryocytes":"48.8","Mononuclear phagocytes":"47.6","Spermatogenic cell types":"100.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1496468.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"169","Protein tissue specific Intensity":{"bone marrow":"16947.0"},"Antibody":["HPA051185"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA051185":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.07e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.44e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.59e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.88e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.30e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"}},{"Gene":"GIT1","Gene synonym":[],"Ensembl":"ENSG00000108262","Gene description":"GIT ArfGAP 1","Uniprot":["Q9Y2X7"],"Chromosome":"17","Position":"29573475-29594054","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"127.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"98.2","Late primary spermatocytes":"99.3","Late spermatids":"134.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"134.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"27000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":80,"Subcellular main location":["Focal adhesion sites","Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA004059":null,"HPA004186":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.04e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.26e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"}},{"Gene":"GJA8","Gene synonym":["CAE","CAE1","CX50","CZP1"],"Ensembl":"ENSG00000121634","Gene description":"Gap junction protein alpha 8","Uniprot":["P48165"],"Chromosome":"1","Position":"147902795-147909269","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"52","RNA tissue specific nTPM":{"testis":"5.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Late primary spermatocytes":"82.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"60","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"82.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":108,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014715":null,"HPA062940":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GJA9","Gene synonym":["CX58","CX59","GJA10"],"Ensembl":"ENSG00000131233","Gene description":"Gap junction protein alpha 9","Uniprot":["P57773"],"Chromosome":"1","Position":"38874069-38881587","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":null,"Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA067850":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GJB6","Gene synonym":["CX30","DFNA3","ED2","EDH","HED"],"Ensembl":"ENSG00000121742","Gene description":"Gap junction protein beta 6","Uniprot":["O95452"],"Chromosome":"13","Position":"20221962-20232365","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Hearing"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Ectodermal dysplasia","Non-syndromic deafness","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"159.8","esophagus":"212.4","vagina":"163.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Esophageal apical cells":"1619.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1619.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"27","RNA single nuclei brain specific nCPM":{"astrocyte":"82.3","fibroblast":"27.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"261.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"2.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"2.6"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bladder cancer":"34.8","cervical cancer":"81.6","Esophageal cancer":"26.2","Gastric cancer":"21.1","head and neck cancer":"45.4"},"RNA tissue cell type enrichment":["Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"8208","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"356139.5","Microglia and Neuropil":"1285412.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"34","Protein tissue specific Intensity":{"cerebral cortex":"3361.5"},"Antibody":["HPA014846"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":11,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA014846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"}},{"Gene":"GJB7","Gene synonym":["bA136M9.1","CX25"],"Ensembl":"ENSG00000164411","Gene description":"Gap junction protein beta 7","Uniprot":["Q6PEY0"],"Chromosome":"6","Position":"87282980-87329278","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"fallopian tube":"6.6","pituitary gland":"5.0","placenta":"2.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"32.9","Cytotrophoblasts":"24.6","Endometrial ciliated cells":"21.2","Epididymal efferent duct ciliated cells":"29.8","Fallopian tube ciliated cells":"23.1","Gonadotrophs":"83.4","Migrating cytotrophoblasts":"16.2","Respiratory ciliated cells":"21.1","Syncytiotrophoblasts":"14.9","Thymocytes":"16.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"29.8","Myocytes":"32.9","Pituitary endocrine cells":"83.4","Trophoblast cells":"24.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Esophageal cancer":"2.2"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014392"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA014392":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GK","Gene synonym":["GK1","GKD"],"Ensembl":"ENSG00000198814","Gene description":"Glycerol kinase","Uniprot":["P32189"],"Chromosome":"X","Position":"30653359-30731462","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Glycerol metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"82.3","kidney":"98.4","liver":"66.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"3826.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"3826.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"neutrophil":"160.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"160.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Proximal tubular cells","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"125247855.7","Proximal tubules":"123285158.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"39753318.2"},"Antibody":["HPA060687"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA060687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.19e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"}},{"Gene":"GK2","Gene synonym":["GKP2","GKTA"],"Ensembl":"ENSG00000196475","Gene description":"Glycerol kinase 2","Uniprot":["Q14410"],"Chromosome":"4","Position":"79406361-79408228","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Glycerol metabolism","Spermatogenesis"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"837","RNA tissue specific nTPM":{"testis":"83.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"31","RNA single cell type specific nCPM":{"Early spermatids":"541.9","Late primary spermatocytes":"671.1","Late spermatids":"205.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"131","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"671.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA060687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GK3P","Gene synonym":["GKP3","GKTB"],"Ensembl":"ENSG00000229894","Gene description":"Glycerol kinase 3 pseudogene","Uniprot":["Q14409"],"Chromosome":"4","Position":"165277807-165279704","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Glycerol metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"testis":"12.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"20","RNA single cell type specific nCPM":{"Early spermatids":"79.7","Late primary spermatocytes":"75.1","Late spermatids":"34.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"25","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"79.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"59","Protein cell type specific Intensity":{"Proximal tubules":"5867.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA060687"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA060687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GKAP1","Gene synonym":["FKSG21","GKAP42"],"Ensembl":"ENSG00000165113","Gene description":"G kinase anchoring protein 1","Uniprot":["Q5VSY0"],"Chromosome":"9","Position":"83739425-83829516","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skeletal muscle":"47.1","testis":"187.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"1297.6","Late primary spermatocytes":"1878.8","Late spermatids":"667.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1878.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":["Centriolar satellite","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035117":null,"HPA035118":null,"HPA066173":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.86e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.52e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.60e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"}},{"Gene":"GLB1L","Gene synonym":["MGC10771"],"Ensembl":"ENSG00000163521","Gene description":"Galactosidase beta 1 like","Uniprot":["Q6UWU2"],"Chromosome":"2","Position":"219236598-219245478","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Glycosidase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"48.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"48.0","Ependymal cells":"29.3","Epididymal efferent duct ciliated cells":"34.8","Fallopian tube ciliated cells":"40.8","Late primary spermatocytes":"191.8","Late spermatids":"27.9","Respiratory ciliated cells":"44.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"191.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"38.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1386","Protein cell type specific Intensity":{"Fallopian tube cells":"128065.5","Glomeruli":"111712.3","Oocytes":"76675.9","Pancreatic islets":"220290.0","Proximal tubules":"156007.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043058"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted - unknown location","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043058":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":10,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA001674":null,"HPA005987":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"}},{"Gene":"GLE1","Gene synonym":["GLE1L","hGLE1","LCCS1"],"Ensembl":"ENSG00000119392","Gene description":"GLE1 RNA export mediator","Uniprot":["Q53GS7"],"Chromosome":"9","Position":"128504655-128543874","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"103.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":56,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA041689":null,"HPA043538":null,"HPA061560":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"}},{"Gene":"GLIPR1L1","Gene synonym":["MGC26856"],"Ensembl":"ENSG00000173401","Gene description":"GLIPR1 like 1","Uniprot":["Q6UWM5"],"Chromosome":"12","Position":"75334670-75370560","Protein class":["Predicted secreted proteins"],"Biological process":["Fertilization"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"53","RNA tissue specific nTPM":{"testis":"28.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"113.1","Cardiomyocytes":"315.6","Early spermatids":"220.7","Epicardial cells":"68.2","Fibro-adipogenic progenitors":"82.3","Late primary spermatocytes":"503.2","Myonuclei":"67.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"113.1","Myocytes":"315.6","Spermatogenic cell types":"503.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042095":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":52,"Subcellular main location":["Nuclear bodies","Plasma membrane"],"Subcellular additional location":["Golgi apparatus","Centrosome"],"Antibody RRID":{"CAB080541":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GLRA3","Gene synonym":[],"Ensembl":"ENSG00000145451","Gene description":"Glycine receptor alpha 3","Uniprot":["O75311"],"Chromosome":"4","Position":"174636920-174829247","Protein class":["FDA approved drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Chloride channel","Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"5.2","breast":"1.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"31.9","Brain excitatory neurons":"59.5","Brain inhibitory neurons":"33.8","Breast hormone-responsive cells":"55.4","Early spermatids":"42.0","Gonadotrophs":"63.0","Late spermatids":"30.7","Other brain neurons":"72.9","Pancreatic islet cells":"26.8","Retinal amacrine cells":"116.2","Somatotrophs":"18.5","Thyrotrophs":"31.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"31.9","Luminal cells":"55.4","Neuronal cells":"116.2","Pituitary endocrine cells":"63.0","Spermatogenic cell types":"42.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"amygdala excitatory":"161.0","upper-layer intratelencephalic":"145.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"2.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"1.4"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA078885":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA023087":null,"HPA057224":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.26e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.77e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"}},{"Gene":"GLRX3","Gene synonym":["bA500G10.4","GLRX4","GRX3","GRX4","PICOT","TXNL2"],"Ensembl":"ENSG00000108010","Gene description":"Glutaredoxin 3","Uniprot":["O76003"],"Chromosome":"10","Position":"130136391-130184521","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"319.3","Late primary spermatocytes":"367.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"67586211.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028941"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"670000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":118,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028941":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.05e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.86e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.53e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.17e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.19e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"}},{"Gene":"GLT1D1","Gene synonym":["FLJ31978"],"Ensembl":"ENSG00000151948","Gene description":"Glycosyltransferase 1 domain containing 1","Uniprot":["Q96MS3"],"Chromosome":"12","Position":"128853427-128984968","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"26.5","choroid plexus":"20.0","liver":"25.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Neutrophil progenitors":"680.3","Neutrophils":"2708.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Neutrophils":"2708.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"9.1","Testicular Germ Cell Tumor (TCGA)":"4.5","Thyroid Carcinoma (TCGA)":"7.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"36.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"36.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"3.3"},"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Colon - Colon enteroendocrine cells","Lung - Neutrophils_2","Spleen - Neutrophils_2","Stomach - Neutrophils","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"125628.5","Microglia and Neuropil":"197481.4","T-cells":"258069.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"249","Protein tissue specific Intensity":{"cerebral cortex":"20163.6","lymphoid tissue":"29571.4"},"Antibody":["HPA039051","HPA039052"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039051":null,"HPA039052":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GLT6D1","Gene synonym":["GLTDC1"],"Ensembl":"ENSG00000204007","Gene description":"Glycosyltransferase 6 domain containing 1","Uniprot":["Q7Z4J2"],"Chromosome":"9","Position":"135623648-135639540","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"testis":"4.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"45.0","Endometrial glandular cells":"9.4","Late primary spermatocytes":"6.9","Late spermatids":"15.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"45.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"1.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023424"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023424":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":28,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA008808":null,"HPA010588":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"GLTP","Gene synonym":[],"Ensembl":"ENSG00000139433","Gene description":"Glycolipid transfer protein","Uniprot":["Q9NZD2"],"Chromosome":"12","Position":"109850945-109880541","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"314.7","skin 1":"257.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"3041.5","Esophageal suprabasal cells":"1065.1","Suprabasal keratinocytes":"637.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"3041.5","Suprabasal cells":"1065.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"229.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"319.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland basal cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"42204094.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"67178726.7"},"Antibody":["HPA056461","HPA065503"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA056461":null,"HPA065503":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.47e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.13e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-4"}},{"Gene":"GMCL1","Gene synonym":["BTBD13","FLJ13057","GCL1","SPATA29"],"Ensembl":"ENSG00000087338","Gene description":"Germ cell-less 1, spermatogenesis associated","Uniprot":["Q96IK5"],"Chromosome":"2","Position":"69829660-69881384","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"375.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"375.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"93.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":68,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039579":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-1"},"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039579":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043663":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GMNN","Gene synonym":["Gem"],"Ensembl":"ENSG00000112312","Gene description":"Geminin DNA replication inhibitor","Uniprot":["O75496"],"Chromosome":"6","Position":"24774931-24786099","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["DNA replication inhibitor"],"Disease involvement":["Cancer-related genes","Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"218.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"235.2","Endometrial luminal cells":"312.7","Enteric stem cells":"250.5","Enteric transient amplifying cells":"215.1","Late primary spermatocytes":"247.0","Oocytes":"432.9","Pancreatic duct cells":"215.2","Prostatic glandular cells":"197.4","Urothelial cells":"185.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Luminal cells":"312.7","Oocytes":"432.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Basal body","Cytosol"],"Antibody RRID":{"CAB011458":null,"CAB047327":null,"CAB047328":null,"HPA049977":null,"HPA054597":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"}},{"Gene":"GMPS","Gene synonym":["GATD7"],"Ensembl":"ENSG00000163655","Gene description":"Guanine monophosphate synthase","Uniprot":["P49915"],"Chromosome":"3","Position":"155870650-155944020","Protein class":["Disease related genes","Enzymes","Essential proteins","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["GMP biosynthesis","Purine biosynthesis"],"Molecular function":["Ligase"],"Disease involvement":["Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"93.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"228.7","Late primary spermatocytes":"467.6","Late spermatids":"267.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"467.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"110412924.5"},"Antibody":["HPA046630"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"53000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":10,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA046630":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.26e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.28e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.44e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.26e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.78e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.88e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.90e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.37e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-3"}},{"Gene":"GNA11","Gene synonym":["FBH","FBH2","FHH2","HHC2"],"Ensembl":"ENSG00000088256","Gene description":"G protein subunit alpha 11","Uniprot":["P29992"],"Chromosome":"19","Position":"3094362-3123999","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction"],"Molecular function":["Hydrolase","Transducer"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"219.0","Enterocytes":"313.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"313.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"5.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048886"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048886":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"}},{"Gene":"GNA14","Gene synonym":[],"Ensembl":"ENSG00000156049","Gene description":"G protein subunit alpha 14","Uniprot":["O95837"],"Chromosome":"9","Position":"77423079-77648322","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"374.8","Choroid plexus epithelial cells":"319.0","Goblet cells":"195.6","Myosatellite cells":"269.5","Pituitary stem cells":"290.4","Prostatic club cells":"157.3","Respiratory ciliated cells":"657.0","Respiratory deuterosomal cells":"167.9","Transitional alveolar cells":"160.4","Tuft cells":"184.5","Vascular endothelial cells":"292.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"657.0","Glial cells":"374.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"291.4","choroid plexus epithelial cell":"281.8","hippocampal dentate gyrus":"273.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"96","RNA blood cell specific nTPM":{"basophil":"27.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"96","RNA blood lineage specific nTPM":{"granulocytes":"27.4"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Bone cancer":"14.9","Rhabdoid":"4.5"},"RNA tissue cell type enrichment":["Skin - Endothelial cells","Spleen - Fibroblasts_1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"123934.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"12022154.5","ovary":"12875407.8"},"Antibody":["HPA048886"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048886":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.88e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA045393":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA071345":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.50e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":36,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB032623":null,"HPA043651":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"}},{"Gene":"GNL1","Gene synonym":["HSR1"],"Ensembl":"ENSG00000204590","Gene description":"G protein nucleolar 1 (putative)","Uniprot":["P36915"],"Chromosome":"6","Position":"30541381-30556489","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"39.6","Early spermatids":"45.2","Late primary spermatocytes":"63.0","Late spermatids":"125.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"125.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5500","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB033575":null,"HPA043338":null,"HPA050455":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"}},{"Gene":"GNPAT","Gene synonym":["DAP-AT","DAPAT","DHAPAT"],"Ensembl":"ENSG00000116906","Gene description":"Glyceronephosphate O-acyltransferase","Uniprot":["O15228"],"Chromosome":"1","Position":"231241207-231277973","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Cataract","Disease variant","Dwarfism","Rhizomelic chondrodysplasia punctata"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"214.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"214.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":8,"Subcellular main location":["Vesicles","Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA039130":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"220000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044647":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.41e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"}},{"Gene":"GOLGA4","Gene synonym":["GCP2","GOLG","golgin-240","p230"],"Ensembl":"ENSG00000144674","Gene description":"Golgin A4","Uniprot":["Q13439"],"Chromosome":"3","Position":"37243191-37366879","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":10,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035102":null,"HPA040675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.79e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.32e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"}},{"Gene":"GOLGA6A","Gene synonym":["GLP","GOLGA6"],"Ensembl":"ENSG00000159289","Gene description":"Golgin A6 family member A","Uniprot":["Q9NYA3"],"Chromosome":"15","Position":"74069857-74082550","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"12.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"27.9","Late primary spermatocytes":"20.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"31","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"27.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044978","HPA050087","HPA072134"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":69,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB017456":null,"HPA048956":null,"HPA054472":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"}},{"Gene":"GOT1","Gene synonym":["AST","AST1","SGOT"],"Ensembl":"ENSG00000120053","Gene description":"Glutamic-oxaloacetic transaminase 1","Uniprot":["P17174"],"Chromosome":"10","Position":"99396870-99430624","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Amino-acid biosynthesis"],"Molecular function":["Aminotransferase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"478.6","skeletal muscle":"458.7","tongue":"944.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"304.7","Retinal ganglion cells":"239.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Skin - Eccrine sweat gland cells","Stomach - Parietal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"1136365382.3","Skeletal myofibers":"1672980888.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1072998185.6"},"Antibody":["HPA064532","HPA072629"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"43000000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA064532":null,"HPA072629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.47e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.63e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"}},{"Gene":"GOT1L1","Gene synonym":["MGC33309"],"Ensembl":"ENSG00000169154","Gene description":"Glutamic-oxaloacetic transaminase 1 like 1","Uniprot":["Q8NHS2"],"Chromosome":"8","Position":"37934281-37940124","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Aminotransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"32","RNA tissue specific nTPM":{"testis":"13.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"92.0","Late primary spermatocytes":"83.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"82","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"92.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028778":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8300000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":5,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA047611":null,"HPA066482":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025943":null,"HPA018858":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.69e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPANK1","Gene synonym":["ANKRD59","BAT4","D6S54E","G5","GPATCH10"],"Ensembl":"ENSG00000204438","Gene description":"G-patch domain and ankyrin repeats 1","Uniprot":["O95872"],"Chromosome":"6","Position":"31661228-31666283","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"28.7","Early primary spermatocytes":"61.9","Late primary spermatocytes":"95.8","Late spermatids":"28.1","Oocytes":"41.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"41.4","Spermatogenic cell types":"95.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":69,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA006301":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - 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Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"13967027.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029414"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029414":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.21e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"}},{"Gene":"GPATCH11","Gene synonym":["CCDC75","CENP-Y","CENPY","FLJ38348"],"Ensembl":"ENSG00000152133","Gene description":"G-patch domain containing 11","Uniprot":[],"Chromosome":"2","Position":"37084518-37099244","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"106.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"106.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":null,"Protein cell type distribution":null,"Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":null,"Protein tissue distribution":null,"Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038231","HPA038232"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":28,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038231":null,"HPA038232":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.82e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-1"}},{"Gene":"GPATCH2","Gene synonym":["CT110","FLJ10252","GPATC2","Pfa1","PPP1R30"],"Ensembl":"ENSG00000092978","Gene description":"G-patch domain containing 2","Uniprot":["Q9NW75"],"Chromosome":"1","Position":"217426992-217631090","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"319.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027181","HPA027322"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":12,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA027181":null,"HPA027322":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"}},{"Gene":"GPATCH2L","Gene synonym":["C14orf118","FLJ10033","FLJ20689"],"Ensembl":"ENSG00000089916","Gene description":"G-patch domain containing 2 like","Uniprot":["Q9NWQ4"],"Chromosome":"14","Position":"76151916-76254342","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"153","Protein cell type specific Intensity":{"Neurons":"15332.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"431","Protein tissue specific Intensity":{"ovary":"43073.7"},"Antibody":["HPA018856"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA018856":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.08e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"}},{"Gene":"GPC2","Gene synonym":["cerebroglycan","DKFZp547M109","FLJ38962"],"Ensembl":"ENSG00000213420","Gene description":"Glypican 2","Uniprot":["Q8N158"],"Chromosome":"7","Position":"100169606-100177381","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"4.8","skin 1":"5.5","testis":"11.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"8.6","Early primary spermatocytes":"11.2","Early spermatids":"42.3","Late primary spermatocytes":"13.5","Late spermatids":"7.7","Microglia":"6.4","Neuroendocrine cells":"6.3","Oligodendrocyte progenitor cells":"17.5","Thymocytes":"9.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"17.5","Spermatogenic cell types":"42.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"8.4","oligodendrocyte precursor cell":"16.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"13.0","Testicular Germ Cell Tumor (TCGA)":"8.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"45.6"},"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2096","Protein cell type specific Intensity":{"Pancreas epithelial cells":"209608.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB025423"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025423":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"GPD2","Gene synonym":[],"Ensembl":"ENSG00000115159","Gene description":"Glycerol-3-phosphate dehydrogenase 2","Uniprot":["P43304"],"Chromosome":"2","Position":"156435290-156613735","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"504.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"504.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"classical monocyte":"3.3","eosinophil":"1.7","intermediate monocyte":"1.6","myeloid DC":"2.7","neutrophil":"1.1","non-classical monocyte":"2.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"2.7","granulocytes":"1.7","monocytes":"3.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"449448986.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008012","HPA045506"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"240000","Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA008012":null,"HPA045506":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.02e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"}},{"Gene":"GPN1","Gene synonym":["ATPBD1A","MBDIN","NTPBP","RPAP4","XAB1"],"Ensembl":"ENSG00000198522","Gene description":"GPN-loop GTPase 1","Uniprot":["Q9HCN4"],"Chromosome":"2","Position":"27628247-27651511","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"85.7","Late primary spermatocytes":"95.3","Late spermatids":"114.3","Oocytes":"73.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"114.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036793","HPA036794","CAB037303"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":79,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"CAB037303":null,"HPA036793":null,"HPA036794":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.55e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.90e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.20e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"}},{"Gene":"GPN3","Gene synonym":["ATPBD1C","MGC14560"],"Ensembl":"ENSG00000111231","Gene description":"GPN-loop GTPase 3","Uniprot":["Q9UHW5"],"Chromosome":"12","Position":"110452486-110469268","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"139.9","Hofbauer cells":"140.8","Late primary spermatocytes":"235.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"235.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"56.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1467","Protein cell type specific Intensity":{"Oocytes":"146670.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"13","Protein tissue specific Intensity":{"lymphoid tissue":"1288.5"},"Antibody":["HPA039764","HPA047793"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":49,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039764":null,"HPA047793":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.55e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.15e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.35e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.15e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"}},{"Gene":"GPR135","Gene synonym":["HUMNPIIY20","PAFR"],"Ensembl":"ENSG00000181619","Gene description":"G protein-coupled receptor 135","Uniprot":["Q8IZ08"],"Chromosome":"14","Position":"59429022-59465380","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"59.3","Choroid plexus epithelial cells":"54.5","Ependymal cells":"79.4","Lactotrophs":"46.6","Proximal tubule cells":"85.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"79.4","Renal nephron cells":"85.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045337"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR137","Gene synonym":["C11orf4","GPR137A","TM7SF1L1"],"Ensembl":"ENSG00000173264","Gene description":"G protein-coupled receptor 137","Uniprot":["Q96N19"],"Chromosome":"11","Position":"64270062-64289500","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"188.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"175.9","Late primary spermatocytes":"315.7","Late spermatids":"1055.4","Syncytiotrophoblasts":"156.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1055.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Actin filaments"],"Antibody RRID":{"HPA062871":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.25e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.29e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"}},{"Gene":"GPR150","Gene synonym":["PGR11"],"Ensembl":"ENSG00000178015","Gene description":"G protein-coupled receptor 150","Uniprot":["Q8NGU9"],"Chromosome":"5","Position":"95620087-95622142","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.5","pancreas":"6.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"3.3","Extravillous trophoblasts":"8.5","Gastric chief cells":"6.6","Hofbauer cells":"6.4","Innate lymphoid cells":"2.8","Late primary spermatocytes":"5.8","Mast cells":"2.6","Mucous neck cells":"2.4","Oocytes":"4.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"6.6","Mononuclear phagocytes":"6.4","Spermatogenic cell types":"5.8","Trophoblast cells":"8.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR156","Gene synonym":["GABABL","PGR28"],"Ensembl":"ENSG00000175697","Gene description":"G protein-coupled receptor 156","Uniprot":["Q8NFN8"],"Chromosome":"3","Position":"120164645-120285222","Protein class":["G-protein coupled receptors","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"2.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"34.8","Early spermatids":"30.4","Ependymal cells":"32.4","Late primary spermatocytes":"21.5","Late spermatids":"38.1","M\u00fcller glia":"34.3","Oligodendrocyte progenitor cells":"20.6","Retinal ganglion cells":"30.9","Undifferentiated spermatogonia":"26.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"32.4","Glial cells":"34.3","Neuronal cells":"30.9","Spermatogenic cell types":"38.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"31.0","oligodendrocyte precursor cell":"27.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA028642":null,"HPA028644":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR158","Gene synonym":["KIAA1136"],"Ensembl":"ENSG00000151025","Gene description":"G protein-coupled receptor 158","Uniprot":["Q5T848"],"Chromosome":"10","Position":"25174802-25602229","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"10.1","retina":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"423.7","Brain inhibitory neurons":"537.9","Corticotrophs":"201.2","Gonadotrophs":"278.9","Lactotrophs":"853.1","M\u00fcller glia":"237.2","Oligodendrocyte progenitor cells":"427.9","Other brain neurons":"365.6","Retinal amacrine cells":"336.3","Retinal ganglion cells":"262.7","Retinal horizontal cells":"1149.9","Somatotrophs":"465.4","Thyrotrophs":"379.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"427.9","Neuronal cells":"1149.9","Pituitary endocrine cells":"853.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"prostate cancer":"10.9"},"RNA tissue cell type enrichment":["Adrenal gland - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR160","Gene synonym":["GPCR1","GPCR150"],"Ensembl":"ENSG00000173890","Gene description":"G protein-coupled receptor 160","Uniprot":["Q9UJ42"],"Chromosome":"3","Position":"170037995-170085392","Protein class":["G-protein coupled receptors","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"102.0","parathyroid gland":"203.7","retina":"96.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enteric stem cells":"293.5","Enteric transient amplifying cells":"238.9","Enterocytes":"406.4","Gastric chief cells":"338.5","Gastric progenitor cells":"230.7","Mucous neck cells":"210.2","Neuroendocrine cells":"277.7","Neutrophil progenitors":"252.4","Neutrophils":"407.0","Paneth cells":"243.6","Rod photoreceptor cells":"675.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"406.4","Neuronal cells":"675.4","Neutrophils":"407.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"41.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA006970":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.25e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"}},{"Gene":"GPR18","Gene synonym":[],"Ensembl":"ENSG00000125245","Gene description":"G protein-coupled receptor 18","Uniprot":["Q14330"],"Chromosome":"13","Position":"99254732-99261744","Protein class":["G-protein coupled receptors","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"9.1","lymphoid tissue":"36.3","testis":"12.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"58.4","Cardiomyocytes":"67.2","Early spermatids":"231.6","Late spermatids":"301.2","NK-cells":"31.4","T-cells":"31.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"301.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"13.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"65.5","NK-cells":"53.1","T-cells":"42.0"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"17","RNA cell line specific nTPM":{"Leukemia":"6.7","lymphoma":"26.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013873":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.83e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.32e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR19","Gene synonym":[],"Ensembl":"ENSG00000183150","Gene description":"G protein-coupled receptor 19","Uniprot":["Q15760"],"Chromosome":"12","Position":"12660890-12696207","Protein class":["G-protein coupled receptors","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"7.8","pituitary gland":"7.4","testis":"3.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"18.0","Bergmann glia":"14.4","Brain excitatory neurons":"20.9","Brain inhibitory neurons":"20.7","Early primary spermatocytes":"29.3","Ependymal cells":"16.9","Gonadotrophs":"15.4","Lactotrophs":"25.5","Oligodendrocyte progenitor cells":"19.5","Other brain neurons":"17.7","Retinal amacrine cells":"17.0","Somatotrophs":"26.3","Thyrotrophs":"17.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"16.9","Glial cells":"19.5","Neuronal cells":"20.9","Pituitary endocrine cells":"26.3","Spermatogenic cell types":"29.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"12.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"6.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"granulocytes":"2.9","T-cells":"6.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"26.3"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013955":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":27,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA022111":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"GPR65","Gene synonym":["hTDAG8","TDAG8"],"Ensembl":"ENSG00000140030","Gene description":"G protein-coupled receptor 65","Uniprot":["Q8IYL9"],"Chromosome":"14","Position":"88005135-88014811","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":["Apoptosis"],"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"11.9","lymphoid tissue":"9.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"73.1","Innate lymphoid cells":"134.6","Kupffer cells":"168.1","Macrophages":"63.5","Mast cells":"547.0","monocytes":"70.3","Neutrophils":"241.0","NK-cells":"216.8","pDCs":"113.5","T-cells":"143.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Innate lymphoid cells":"134.6","Mast cells":"547.0","Mononuclear phagocytes":"168.1","Neutrophils":"241.0","NK-cells":"216.8","T-cells":"143.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"35","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"43.3","leukocyte":"99.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"3.6","lymphoma":"7.1"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA072624":null,"HPA077397":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR68","Gene synonym":["OGR1"],"Ensembl":"ENSG00000119714","Gene description":"G protein-coupled receptor 68","Uniprot":["Q15743"],"Chromosome":"14","Position":"91232532-91253925","Protein class":["Disease related genes","G-protein coupled receptors","Human disease related genes","Potential drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Amelogenesis imperfecta","Disease variant","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pituitary gland":"11.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"28.8","Epicardial cells":"36.4","Hofbauer cells":"47.3","Innate lymphoid cells":"59.7","NK-cells":"26.5","Somatotrophs":"27.7","T-cells":"28.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"36.4","Innate lymphoid cells":"59.7","Mononuclear phagocytes":"47.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"29.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"22.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"NK-cells":"20.2","T-cells":"22.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pituitary gland - Somatotropes","Skeletal muscle - Fibroblasts","Spleen - T-cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"11776","Protein cell type specific Intensity":{"Microglia and Neuropil":"2128854.3","Neurons":"547649.5","T-cells":"856310.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"22416","Protein tissue specific Intensity":{"lymphoid tissue":"2241631.2"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 104: Brain endothelial cells - Blood brain barrier","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.30e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"GPR87","Gene synonym":["GPR95"],"Ensembl":"ENSG00000138271","Gene description":"G protein-coupled receptor 87","Uniprot":["Q9BY21"],"Chromosome":"3","Position":"151294086-151316820","Protein class":["G-protein coupled receptors","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"42.1","skin 1":"37.4","vagina":"27.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"70.6","Cytotrophoblasts":"67.3","Epididymal basal cells":"378.7","Esophageal apical cells":"295.7","Esophageal basal cells":"74.4","Esophageal suprabasal cells":"139.4","Migrating cytotrophoblasts":"100.0","Ocular epithelial cells":"98.0","Suprabasal keratinocytes":"98.3","Syncytiotrophoblasts":"315.8","Urothelial cells":"127.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"295.7","Barrier epithelial cells":"127.3","Basal cells":"378.7","Suprabasal cells":"139.4","Trophoblast cells":"315.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"9.1"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"34.9","Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"61.7","Head and Neck Squamous Cell Carcinoma (TCGA)":"64.5","Lung Squamous Cell Carcinoma (TCGA)":"58.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"70.8","head and neck cancer":"95.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":null,"Subcellular main location":["Lipid droplets","Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA066313":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GPR89A","Gene synonym":["UNQ192"],"Ensembl":"ENSG00000117262","Gene description":"G protein-coupled receptor 89A","Uniprot":["B7ZAQ6"],"Chromosome":"1","Position":"145607988-145670650","Protein class":["Predicted membrane proteins"],"Biological process":["Ion transport","Protein transport","Transport"],"Molecular function":["Ion channel","Voltage-gated channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Tuft cells":"172.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Secretory gland support":"172.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":6,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA076096":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.74e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.18e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"GPRC5D","Gene synonym":[],"Ensembl":"ENSG00000111291","Gene description":"G protein-coupled receptor class C group 5 member D","Uniprot":["Q9NZD1"],"Chromosome":"12","Position":"12940575-12952170","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skin 1":"26.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"10.2","Early spermatids":"10.0","Endometrial luminal cells":"23.8","Epicardial cells":"100.1","Esophageal apical cells":"12.0","Late spermatids":"25.9","Plasma cells":"37.8","Urothelial cells":"10.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"100.1","Luminal cells":"23.8","Plasma cells":"37.8","Spermatogenic cell types":"25.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1.7","choroid plexus epithelial cell":"2.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"memory B-cell":"14.7","naive B-cell":"4.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"B-cells":"14.7"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"20","RNA cell line specific nTPM":{"Myeloma":"60.8"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 9: Skin - Hair follicle development","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA071909":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.23e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":7,"Subcellular main location":["Plasma membrane","Microtubules"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle"],"Antibody RRID":{"HPA038129":null,"HPA070760":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.29e-4"}},{"Gene":"GPS2","Gene synonym":[],"Ensembl":"ENSG00000132522","Gene description":"G protein pathway suppressor 2","Uniprot":["Q13227"],"Chromosome":"17","Position":"7311324-7315564","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":["Activator","Repressor"],"Disease involvement":["Cancer-related genes","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"35.7","Bergmann glia":"41.6","Brain excitatory neurons":"40.4","Brain inhibitory neurons":"33.9","Choroid plexus epithelial cells":"17.3","Ependymal cells":"23.3","Late spermatids":"22.6","Microglia":"38.6","Oligodendrocyte progenitor cells":"30.5","Oligodendrocytes":"42.9","Other brain neurons":"33.8","Papillary tip epithelial cells":"19.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"23.3","Glial cells":"42.9","Neuronal cells":"40.4","Renal nephron cells":"19.0","Spermatogenic cell types":"22.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":70,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA067540":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"}},{"Gene":"GPSM2","Gene synonym":["DFNB82","LGN","Pins"],"Ensembl":"ENSG00000121957","Gene description":"G protein signaling modulator 2","Uniprot":["P81274"],"Chromosome":"1","Position":"108875350-108934545","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Transport"],"Molecular function":null,"Disease involvement":["Deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"tongue":"50.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"178.0","Esophageal apical cells":"233.7","Fibro-adipogenic progenitors":"217.5","Myosatellite cells":"175.4","Oligodendrocyte progenitor cells":"245.8","Oligodendrocytes":"193.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"264.3","oligodendrocyte precursor cell":"294.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"eosinophil":"2.8","T-reg":"1.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"2.8","T-cells":"1.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7164","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"716448.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"148","Protein tissue specific Intensity":{"intestine":"14820.1"},"Antibody":["HPA007327","HPA008408","CAB018962"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":15,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"CAB018962":null,"HPA007327":null,"HPA008408":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.89e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.14e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.05e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.34e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.66e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"}},{"Gene":"GRAMD1C","Gene synonym":["DKFZp434C0328"],"Ensembl":"ENSG00000178075","Gene description":"GRAM domain containing 1C","Uniprot":["Q8IYS0"],"Chromosome":"3","Position":"113828182-113947174","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"322.7","Endometrial glandular cells":"267.2","Late spermatids":"153.6","Pituitary stem cells":"182.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"267.2","Glial cells":"322.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"343.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"memory B-cell":"2.7","naive B-cell":"3.0","neutrophil":"2.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"B-cells":"3.0","granulocytes":"2.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Liver - Hepatocytes","Stomach - Parietal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"590582.7","Fallopian tube cells":"168535.9","Large ducts":"250460.4","Neurons":"435048.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA012316"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":8,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA012316":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Actin filaments","Primary cilium","Cytosol"],"Antibody RRID":{"HPA059960":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.54e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"}},{"Gene":"GRIA1","Gene synonym":["GluA1","GLUR1","GLURA"],"Ensembl":"ENSG00000155511","Gene description":"Glutamate ionotropic receptor AMPA type subunit 1","Uniprot":["P42261"],"Chromosome":"5","Position":"153489615-153813869","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["Disease variant","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"54.8","retina":"29.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Bergmann glia":"3894.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"3894.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"3812.0","hippocampal CA4":"4632.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"16","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"23.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"6.7"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Lung - Fibroblasts_1","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Stomach - Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"54607","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3982687.8","Microglia and Neuropil":"8853788.8","Neurons":"3545624.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"49088","Protein tissue specific Intensity":{"cerebral cortex":"4908794.9"},"Antibody":["HPA035202"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035202":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GRID2","Gene synonym":["GluD2","GluR-delta-2"],"Ensembl":"ENSG00000152208","Gene description":"Glutamate ionotropic receptor delta type subunit 2","Uniprot":["O43424"],"Chromosome":"4","Position":"92303966-93810157","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"10.5","testis":"31.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Bergmann glia":"16983.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"16983.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"18167.2","cerebellar inhibitory":"19185.0"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"5.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"88.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"5","RNA pig brain regional specific nTPM":{"cerebellum":"99.3"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2725","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"297503.0","Microglia and Neuropil":"247586.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1110","Protein tissue specific Intensity":{"cerebral cortex":"137305.4","salivary gland":"84692.7"},"Antibody":["HPA056253","HPA058538"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056253":null,"HPA058538":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.60e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":3,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA014623":null,"HPA073879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GRIN2B","Gene synonym":["GluN2B","NMDAR2B"],"Ensembl":"ENSG00000273079","Gene description":"Glutamate ionotropic receptor NMDA type subunit 2B","Uniprot":["Q13224"],"Chromosome":"12","Position":"13437942-13982002","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","RAS pathway related proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"17","RNA tissue specific nTPM":{"brain":"6.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"677.9","Brain inhibitory neurons":"895.2","Oligodendrocyte progenitor cells":"253.8","Other brain neurons":"372.0","Pituitary stem cells":"97.1","Retinal amacrine cells":"169.6","Retinal ganglion cells":"104.3","Tuft cells":"184.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"253.8","Neuronal cells":"895.2","Secretory gland support":"184.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"1.1","Rectum Adenocarcinoma (TCGA)":"1.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"1.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":26,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Primary cilium","Primary cilium tip","Primary cilium transition zone","Basal body"],"Antibody RRID":{"HPA052160":null,"HPA069762":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GRIN3A","Gene synonym":["GluN3A"],"Ensembl":"ENSG00000198785","Gene description":"Glutamate ionotropic receptor NMDA type subunit 3A","Uniprot":["Q8TCU5"],"Chromosome":"9","Position":"101569352-101738647","Protein class":["FDA approved drug targets","Predicted membrane proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"7.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"49.3","Brain inhibitory neurons":"108.2","Epicardial cells":"13.6","Other brain neurons":"47.6","Prostatic glandular cells":"18.6","Retinal amacrine cells":"23.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"108.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"410.7","MGE interneuron":"314.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"4.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"3.1","prostate cancer":"3.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GRINA","Gene synonym":["HNRGW","LFG1","NMDARA1","TMBIM3"],"Ensembl":"ENSG00000178719","Gene description":"Glutamate ionotropic receptor NMDA type subunit associated protein 1","Uniprot":["Q7Z429"],"Chromosome":"8","Position":"143990056-143993415","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"283.0","Hepatocytes":"227.7","Kupffer cells":"285.9","Late spermatids":"756.4","Neutrophils":"397.2","Syncytiotrophoblasts":"294.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"397.2","Spermatogenic cell types":"756.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Heart muscle - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036980","HPA036981"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":6,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036980":null,"HPA036981":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"}},{"Gene":"GRIP1","Gene synonym":[],"Ensembl":"ENSG00000155974","Gene description":"Glutamate receptor interacting protein 1","Uniprot":["Q9Y3R0"],"Chromosome":"12","Position":"66347431-67069162","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"15.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"744.6","Brain inhibitory neurons":"1318.6","Lactotrophs":"769.9","Papillary tip epithelial cells":"833.7","Renal collecting duct intercalated cells":"1374.8","Renal collecting duct principal cells":"3017.4","Renal connecting tubule cells":"1419.6","Retinal amacrine cells":"1979.7","Retinal horizontal cells":"1037.7","Syncytiotrophoblasts":"964.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"3017.4","Neuronal cells":"1979.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"4821.4","MGE interneuron":"2856.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"myeloid DC":"4.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"4.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Pituitary gland - Lactotropes","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1342975.5","Microglia and Neuropil":"1005033.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7610","Protein tissue specific Intensity":{"cerebral cortex":"761025.3"},"Antibody":["HPA038856"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":30,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038856":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"}},{"Gene":"GRK3","Gene synonym":["ADRBK2","BARK2"],"Ensembl":"ENSG00000100077","Gene description":"G protein-coupled receptor kinase 3","Uniprot":["P35626"],"Chromosome":"22","Position":"25564675-25729294","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"19.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"987.4","B-cells":"311.8","cDC":"375.7","Macrophages":"315.6","Microglia":"315.8","monocytes":"338.4","Podocytes":"311.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"987.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"classical monocyte":"2.3","eosinophil":"2.4","intermediate monocyte":"3.8","memory B-cell":"2.4","myeloid DC":"1.7","naive B-cell":"2.8","non-classical monocyte":"4.3","plasmacytoid DC":"1.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"38.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Colon - Colon enteroendocrine cells","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"948456.0","T-cells":"972594.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"9427837.7"},"Antibody":["HPA000804"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA000804":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"}},{"Gene":"GRK4","Gene synonym":["GPRK2L","GPRK4"],"Ensembl":"ENSG00000125388","Gene description":"G protein-coupled receptor kinase 4","Uniprot":["P32298"],"Chromosome":"4","Position":"2963571-3040760","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"39.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"219.4","Early primary spermatocytes":"182.6","Early spermatids":"371.1","Late primary spermatocytes":"432.2","Late spermatids":"753.9","Retinal ganglion cells":"173.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"219.4","Spermatogenic cell types":"753.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Pituitary gland - Somatotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA057023"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol","Calyx"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":3,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Calyx"],"Antibody RRID":{"HPA057023":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.01e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GRM5","Gene synonym":["GPRC1E","mGlu5","MGLUR5","PPP1R86"],"Ensembl":"ENSG00000168959","Gene description":"Glutamate metabotropic receptor 5","Uniprot":["P41594"],"Chromosome":"11","Position":"88504576-89065982","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"13.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"929.7","Brain excitatory neurons":"870.3","Brain inhibitory neurons":"1299.0","Early spermatids":"267.4","Endometrial ciliated cells":"230.1","Gonadotrophs":"304.4","Lactotrophs":"291.9","Oligodendrocyte progenitor cells":"1160.3","Other brain neurons":"430.4","Retinal amacrine cells":"220.1","Retinal bipolar cells":"713.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"1160.3","Neuronal cells":"1299.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"2.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Gallbladder cancer":"2.6"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GRM7","Gene synonym":["GLUR7","GPRC1G","mGlu7","MGLUR7","PPP1R87"],"Ensembl":"ENSG00000196277","Gene description":"Glutamate metabotropic receptor 7","Uniprot":["Q14831"],"Chromosome":"3","Position":"6770001-7741533","Protein class":["Disease related genes","G-protein coupled receptors","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Sensory transduction"],"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Cardiomyopathy","Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"5.3","parathyroid gland":"4.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"1138.1","Brain excitatory neurons":"1036.8","Brain inhibitory neurons":"1029.7","Oligodendrocyte progenitor cells":"1533.4","Other brain neurons":"753.5","Respiratory ciliated cells":"276.1","Retinal amacrine cells":"909.6","Retinal bipolar cells":"816.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"1138.1","Glial cells":"1533.4","Neuronal cells":"1036.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"mammillary body":"3463.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051481":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.99e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":251,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB016263":null,"CAB080481":null,"CAB080483":null,"CAB080485":null,"CAB080488":null,"CAB080489":null,"HPA006495":null,"HPA028017":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-3"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"}},{"Gene":"GSKIP","Gene synonym":["C14orf129"],"Ensembl":"ENSG00000100744","Gene description":"GSK3B interacting protein","Uniprot":["Q9P0R6"],"Chromosome":"14","Position":"96363452-96387288","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"440.7","Esophageal apical cells":"336.0","Late spermatids":"419.0","Oocytes":"165.8","Syncytiotrophoblasts":"151.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"336.0","Spermatogenic cell types":"440.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043054","HPA046782"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":10,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA043054":null,"HPA046782":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.91e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"}},{"Gene":"GSTCD","Gene synonym":["FLJ13273"],"Ensembl":"ENSG00000138780","Gene description":"Glutathione S-transferase C-terminal domain containing","Uniprot":["Q8NEC7"],"Chromosome":"4","Position":"105708778-105847725","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"311.7","Epicardial cells":"200.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"200.1","Spermatogenic cell types":"311.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"5.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"373660.6","Keratinocytes":"364048.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"59165.3"},"Antibody":["HPA046160","HPA061782"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA046160":null,"HPA061782":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.35e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"}},{"Gene":"GSTM3","Gene synonym":["GST5"],"Ensembl":"ENSG00000134202","Gene description":"Glutathione S-transferase mu 3","Uniprot":["P21266"],"Chromosome":"1","Position":"109733932-109741038","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"93.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1991.2","Late primary spermatocytes":"3268.9","Late spermatids":"6017.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6017.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"155.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"2.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"98846492.9","Distal tubules":"103932349.1","Oocytes":"170057232.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017130","HPA035190","CAB040583","HPA055972"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Cytokinetic bridge","Primary cilium","Primary cilium tip","Primary cilium transition zone","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"650000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":36,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Microtubules","Cytokinetic bridge","Primary cilium","Primary cilium tip","Primary cilium transition zone"],"Antibody RRID":{"CAB017130":null,"CAB040583":null,"HPA035190":null,"HPA055972":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.00e-6"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"250000","Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA004701":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA074358":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"GTF2A2","Gene synonym":["HsT18745","TFIIA"],"Ensembl":"ENSG00000140307","Gene description":"General transcription factor IIA subunit 2","Uniprot":["P52657"],"Chromosome":"15","Position":"59638062-59657541","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"457.5","Early spermatids":"806.0","Esophageal apical cells":"465.9","Late primary spermatocytes":"2591.5","Late spermatids":"1039.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2591.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":16,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044897":null,"HPA077202":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.49e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":60,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA022793":null,"HPA028707":null,"HPA070752":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":69,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB004637":null,"HPA046660":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"}},{"Gene":"GTF2H5","Gene synonym":["bA120J8.2","C6orf175","FLJ30544","TFB5","TFIIH","TTD","TTD-A","TTDA"],"Ensembl":"ENSG00000272047","Gene description":"General transcription factor IIH subunit 5","Uniprot":["Q6ZYL4"],"Chromosome":"6","Position":"158168350-158199344","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":["Disease variant","Ichthyosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"355.7","Esophageal apical cells":"475.2","Esophageal suprabasal cells":"392.1","Late primary spermatocytes":"494.9","Parietal cells":"397.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"494.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":32,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.36e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA056179":null,"HPA061345":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.73e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.79e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.08e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.16e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"}},{"Gene":"GTPBP8","Gene synonym":["HSPC135"],"Ensembl":"ENSG00000163607","Gene description":"GTP binding protein 8 (putative)","Uniprot":["Q8N3Z3"],"Chromosome":"3","Position":"112990984-113015060","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"140.8","Late primary spermatocytes":"151.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"140.8","Spermatogenic cell types":"151.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA034831":null,"HPA058631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"}},{"Gene":"GTSE1","Gene synonym":["B99","GTSE-1","Lnc_bc060912"],"Ensembl":"ENSG00000075218","Gene description":"G2 and S-phase expressed 1","Uniprot":["Q9NYZ3"],"Chromosome":"22","Position":"46296870-46330810","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"10.5","lymphoid tissue":"18.2","testis":"7.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"49.4","Early primary spermatocytes":"71.6","Enteric transient amplifying cells":"43.5","Erythrocyte progenitors":"65.6","Esophageal basal cells":"32.4","Extravillous trophoblasts":"40.4","Gastric progenitor cells":"35.9","Hofbauer cells":"42.5","Late primary spermatocytes":"42.0","Megakaryocyte progenitors":"68.4","Migrating cytotrophoblasts":"33.8","Monocyte progenitors":"158.1","Neutrophil progenitors":"52.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"65.6","Megakaryocytes":"68.4","Mononuclear phagocytes":"158.1","Spermatogenic cell types":"71.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"158","Protein cell type specific Intensity":{"Granulosa cells":"15776.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1421","Protein tissue specific Intensity":{"fallopian tube":"213398.3","skin":"70796.3"},"Antibody":["HPA029457"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Primary cilium","Primary cilium tip","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":21,"Subcellular main location":["Plasma membrane","Centrosome"],"Subcellular additional location":["Nucleoplasm","Primary cilium","Primary cilium tip","Basal body","Cytosol"],"Antibody RRID":{"HPA029457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.05e-5"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.96e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.71e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.08e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.20e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.82e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.23e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.28e-5"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038876":null,"HPA038877":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"}},{"Gene":"GUCA1C","Gene synonym":["GCAP3"],"Ensembl":"ENSG00000138472","Gene description":"Guanylate cyclase activator 1C","Uniprot":["O95843"],"Chromosome":"3","Position":"108907792-108953879","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"retina":"274.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"596.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Neuronal cells":"596.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"7.7","hippocampal CA4":"27.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"14","RNA cell line specific nTPM":{"Kidney cancer":"6.9"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":["Focal adhesion sites"],"Subcellular additional location":null,"Antibody RRID":{"HPA041597":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"560000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA036322":null,"HPA036323":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"}},{"Gene":"GYG1","Gene synonym":["GYG"],"Ensembl":"ENSG00000163754","Gene description":"Glycogenin 1","Uniprot":["P46976"],"Chromosome":"3","Position":"148991408-149031775","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Glycogen biosynthesis"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Glycogen storage disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"535.2","tongue":"333.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"609.9","Late spermatids":"617.9","Neutrophil progenitors":"583.7","Neutrophils":"608.9","Oocytes":"1201.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neutrophils":"608.9","Oocytes":"1201.9","Spermatogenic cell types":"617.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"169.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":13,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA030497":null,"HPA073229":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.82e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.20e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"GZF1","Gene synonym":["dJ322G13.2","ZBTB23","ZNF336"],"Ensembl":"ENSG00000125812","Gene description":"GDNF inducible zinc finger protein 1","Uniprot":["Q9H116"],"Chromosome":"20","Position":"23362182-23373062","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"42.9","Neutrophils":"39.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":6,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA024520":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037992":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA041189":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"}},{"Gene":"H2AZ1","Gene synonym":["H2A.Z","H2AFZ","H2AZ"],"Ensembl":"ENSG00000164032","Gene description":"H2A.Z variant histone 1","Uniprot":["P0C0S5"],"Chromosome":"4","Position":"99948086-99950355","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"1384.9","Esophageal basal cells":"1905.9","Extravillous trophoblasts":"1621.5","Migrating cytotrophoblasts":"1125.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"1905.9","Trophoblast cells":"1621.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 41: Non-specific - Nucleosome assembly","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":48,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA042205":null,"HPA043013":null,"HPA048671":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"40000000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":46,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB037166":null,"CAB037187":null,"CAB037221":null,"HPA042570":null,"HPA050968":null,"HPA064058":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":24,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA042570":null,"HPA050968":null,"HPA064058":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"}},{"Gene":"HACE1","Gene synonym":["KIAA1320"],"Ensembl":"ENSG00000085382","Gene description":"HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1","Uniprot":["Q8IYU2"],"Chromosome":"6","Position":"104728094-104859919","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"28.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"126.3","Retinal horizontal cells":"144.2","Rod photoreceptor cells":"160.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"160.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"12533070.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"2304184.1"},"Antibody":["HPA046071"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":14,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA046071":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.63e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"}},{"Gene":"HACL1","Gene synonym":["2-HPCL","HPCL","PHYH2"],"Ensembl":"ENSG00000131373","Gene description":"2-hydroxyacyl-CoA lyase 1","Uniprot":["Q9UJ83"],"Chromosome":"3","Position":"15560699-15601852","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"115.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"115.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"12097347.9","Oocytes":"12658766.9","Proximal tubules":"9475205.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"8871938.2"},"Antibody":["HPA035496","HPA035497","HPA073760"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035496":null,"HPA035497":null,"HPA073760":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.53e-6"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"}},{"Gene":"HAGH","Gene synonym":["GLO2","GLXII","HAGH1"],"Ensembl":"ENSG00000063854","Gene description":"Hydroxyacylglutathione hydrolase","Uniprot":["Q16775"],"Chromosome":"16","Position":"1795620-1827157","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"429.4","Oocytes":"280.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"429.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Smooth muscle cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"276179364.3"},"Antibody":["HPA043041","HPA061143"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2200000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043041":null,"HPA061143":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.92e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.82e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"}},{"Gene":"HAPSTR1","Gene synonym":["C16orf72","FLJ41272","PRO0149","TAPR1"],"Ensembl":"ENSG00000182831","Gene description":"HUWE1 associated protein modifying stress responses","Uniprot":["Q14CZ0"],"Chromosome":"16","Position":"9091644-9121635","Protein class":["Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"100.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"258.3","Late spermatids":"1080.7","Neutrophils":"369.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Neutrophils":"369.7","Spermatogenic cell types":"1080.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3625","Protein cell type specific Intensity":{"Neurons":"362517.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041568","HPA067492"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":36,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA041568":null,"HPA067492":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.98e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"}},{"Gene":"HARBI1","Gene synonym":["C11orf77","FLJ32675"],"Ensembl":"ENSG00000180423","Gene description":"Harbinger transposase derived 1","Uniprot":["Q96MB7"],"Chromosome":"11","Position":"46602861-46617909","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"11.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"92.7","Early spermatids":"92.2","Epicardial cells":"45.5","Late primary spermatocytes":"34.8","Late spermatids":"110.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"45.5","Myocytes":"92.7","Spermatogenic cell types":"110.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038671","HPA045457"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038671":null,"HPA045457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"}},{"Gene":"HASPIN","Gene synonym":["GSG2"],"Ensembl":"ENSG00000177602","Gene description":"Histone H3 associated protein kinase","Uniprot":["Q8TF76"],"Chromosome":"17","Position":"3723903-3726699","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Chromatin regulator","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"5.7","lymphoid tissue":"5.0","testis":"6.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"3.8","Early primary spermatocytes":"3.7","Early spermatids":"17.2","Erythrocyte progenitors":"5.0","Extravillous trophoblasts":"3.6","Late primary spermatocytes":"34.1","Late spermatids":"9.7","Megakaryocyte progenitors":"6.6","Monocyte progenitors":"7.1","Plasma cells":"3.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"34.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Breast - T-cells","Colon - Mitotic cells (Colon)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Prostate - T-cells","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"84","Protein cell type specific Intensity":{"Neutrophils":"8395.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"14","Protein tissue specific Intensity":{"intestine":"1387.8"},"Antibody":["HPA027422","HPA030698"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA027422":null,"HPA030698":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.69e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.25e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"}},{"Gene":"HAUS6","Gene synonym":["dgt6","FAM29A","FLJ20060","KIAA1574"],"Ensembl":"ENSG00000147874","Gene description":"HAUS augmin like complex subunit 6","Uniprot":["Q7Z4H7"],"Chromosome":"9","Position":"19053141-19102904","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"88.0","Early spermatids":"132.1","Erythrocyte progenitors":"101.5","Late primary spermatocytes":"92.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"101.5","Spermatogenic cell types":"132.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"13831080.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1770683.9","lymphoid tissue":"462250.7"},"Antibody":["HPA020960","HPA020965"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Centriolar satellite","Cytosol","Acrosome","Connecting piece","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":33,"Subcellular main location":["Centriolar satellite","Cytosol","Acrosome"],"Subcellular additional location":["Nuclear speckles","Connecting piece","Mid piece","Principal piece"],"Antibody RRID":{"HPA020960":null,"HPA020965":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.60e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.06e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"}},{"Gene":"HAVCR1","Gene synonym":["CD365","HAVCR","HAVCR-1","KIM1","TIM-1","TIM1","TIMD1"],"Ensembl":"ENSG00000113249","Gene description":"Hepatitis A virus cellular receptor 1","Uniprot":["Q96D42"],"Chromosome":"5","Position":"157026742-157069396","Protein class":["CD markers","Predicted membrane proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["Host cell receptor for virus entry","Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"intestine":"4.3","kidney":"6.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Proximal tubule cells":"70.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Renal nephron cells":"70.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"9.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"13","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"56.0","Kidney Renal Papillary Cell Carcinoma (TCGA)":"69.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"2.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Kidney cancer":"194.7"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA007173","CAB075697"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB075697":null,"HPA007173":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.21e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"}},{"Gene":"HAX1","Gene synonym":["HAX-1","HCLSBP1","HS1BP1"],"Ensembl":"ENSG00000143575","Gene description":"HCLS1 associated protein X-1","Uniprot":["O00165"],"Chromosome":"1","Position":"154272355-154275875","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"302.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA055141","HPA075289"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":46,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA055141":null,"HPA075289":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.25e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.45e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.45e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"}},{"Gene":"HBP1","Gene synonym":[],"Ensembl":"ENSG00000105856","Gene description":"HMG-box transcription factor 1","Uniprot":["O60381"],"Chromosome":"7","Position":"107168961-107202522","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"487.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"487.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":11,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB032824":null,"HPA020225":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.86e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.98e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"HCFC2","Gene synonym":["HCF-2"],"Ensembl":"ENSG00000111727","Gene description":"Host cell factor C2","Uniprot":["Q9Y5Z7"],"Chromosome":"12","Position":"104064531-104106524","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"235.9","Late primary spermatocytes":"334.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"334.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA006227":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-3"}},{"Gene":"HDAC4","Gene synonym":["BDMR","HA6116","HD4","HDAC-4","HDAC-A","HDACA","KIAA0288"],"Ensembl":"ENSG00000068024","Gene description":"Histone deacetylase 4","Uniprot":["P56524"],"Chromosome":"2","Position":"239048168-239401654","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Hydrolase","Repressor"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"33.2","tongue":"24.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"1091.2","Neutrophils":"672.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"1091.2","Neutrophils":"672.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"32.0","neutrophil":"47.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"47.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Fibroblasts","Minor Salivary Gland - Endothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"12833788.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048723","HPA071448"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":89,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA048723":null,"HPA071448":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.12e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.36e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"}},{"Gene":"HDAC9","Gene synonym":["HD7","HDAC","HDAC7B","KIAA0744","MITR"],"Ensembl":"ENSG00000048052","Gene description":"Histone deacetylase 9","Uniprot":["Q9UKV0"],"Chromosome":"7","Position":"18086949-19002416","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Hydrolase","Repressor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"2648.6","cDC":"1768.4","Choroid plexus epithelial cells":"4756.6","Corticotrophs":"1277.6","Microglia":"1354.3","Retinal ganglion cells":"1031.4","Thyrotrophs":"1737.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"2648.6","Ciliated cells":"4756.6","dendritic cells":"1768.4","Pituitary endocrine cells":"1737.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"3812.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"73.7"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"B-cells":"53.2","dendritic cells":"73.7","monocytes":"24.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Prostate - Smooth muscle cells","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"326658.1","Neurons":"898211.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"231","Protein tissue specific Intensity":{"lymphoid tissue":"23059.6"},"Antibody":["HPA028926"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitotic chromosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitotic chromosome"],"Antibody RRID":{"HPA028926":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"}},{"Gene":"HDDC2","Gene synonym":["C6orf74","CGI-130","dJ167O5.2"],"Ensembl":"ENSG00000111906","Gene description":"HD domain containing 2","Uniprot":["Q7Z4H3"],"Chromosome":"6","Position":"125219962-125302078","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"156.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"334.3","Myonuclei":"265.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"334.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035677"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":3,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035677":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"}},{"Gene":"HDGFL1","Gene synonym":["dJ309H15.1","Hdgfrp1","HRP-1","PWWP1"],"Ensembl":"ENSG00000112273","Gene description":"HDGF like 1","Uniprot":["Q5TGJ6"],"Chromosome":"6","Position":"22569566-22571666","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"212","RNA tissue specific nTPM":{"testis":"87.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"3.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"38","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"48","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"33.0"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"1.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Gallbladder cancer":"1.1"},"RNA tissue cell type enrichment":["Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"323","Protein cell type specific Intensity":{"Oocytes":"32337.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045679","HPA063707"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA045679":null,"HPA063707":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HDGFL2","Gene synonym":["Hdgfrp2","HRP2"],"Ensembl":"ENSG00000167674","Gene description":"HDGF like 2","Uniprot":["Q7Z4V5"],"Chromosome":"19","Position":"4472297-4502208","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Myogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"85.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"5.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"16656171.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"58601133.6"},"Antibody":["HPA042559","HPA044208"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria","Cytosol"],"Antibody RRID":{"HPA042559":null,"HPA044208":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.01e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"}},{"Gene":"HDLBP","Gene synonym":["HBP","VGL"],"Ensembl":"ENSG00000115677","Gene description":"High density lipoprotein binding protein","Uniprot":["Q00341"],"Chromosome":"2","Position":"241227264-241317061","Protein class":["Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cholesterol metabolism","Lipid metabolism","Lipid transport","Steroid metabolism","Sterol metabolism","Transport"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"735.3","Late spermatids":"710.9","Pancreatic acinar cells":"733.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"746120818.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"285859457.0","Stomach":"625390361.4"},"Antibody":["HPA004189","CAB026457","HPA070707"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"53000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":73,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"CAB026457":null,"HPA004189":null,"HPA070707":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.79e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.63e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.52e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"}},{"Gene":"HEATR4","Gene synonym":["MGC48595"],"Ensembl":"ENSG00000187105","Gene description":"HEAT repeat containing 4","Uniprot":["Q86WZ0"],"Chromosome":"14","Position":"73478484-73558947","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"66.2","Cardiomyocytes":"141.9","Early spermatids":"157.7","Late primary spermatocytes":"164.6","Late spermatids":"104.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"141.9","Spermatogenic cell types":"164.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2141","Protein cell type specific Intensity":{"Fallopian tube cells":"214057.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003642","HPA079348"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA003642":null,"HPA079348":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HEATR9","Gene synonym":["C17orf66","FLJ32830"],"Ensembl":"ENSG00000270379","Gene description":"HEAT repeat containing 9","Uniprot":["A2RTY3"],"Chromosome":"17","Position":"35854946-35868891","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"testis":"9.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"7.9","Late primary spermatocytes":"4.4","Late spermatids":"4.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"7.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"5.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023129":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":6,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA007203":null,"HPA007593":null,"HPA007609":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.33e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"}},{"Gene":"HEMGN","Gene synonym":["CT155","EDAG","NDR"],"Ensembl":"ENSG00000136929","Gene description":"Hemogen","Uniprot":["Q9BXL5"],"Chromosome":"9","Position":"97926791-97944856","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"232.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1790.2","Erythrocyte progenitors":"544.5","Erythrocytes":"326.5","Hematopoietic stem cells":"174.2","Late spermatids":"2277.6","Megakaryocyte progenitors":"166.5","Megakaryocytes":"463.6","Platelets":"412.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2277.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"5.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"28","RNA blood lineage specific nTPM":{"granulocytes":"2.2","NK-cells":"2.0","T-cells":"5.1"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"14.2"},"RNA tissue cell type enrichment":["Liver - Erythroid cells","Lung - Neutrophils_1","Spleen - Erythrocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"31924","Protein cell type specific Intensity":{"Neutrophils":"3192379.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"509847","Protein tissue specific Intensity":{"bone marrow":"50984659.5"},"Antibody":["HPA019572","HPA019604","HPA019606"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA019572":null,"HPA019604":null,"HPA019606":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HENMT1","Gene synonym":["C1orf59","FLJ30525","HEN1"],"Ensembl":"ENSG00000162639","Gene description":"HEN methyltransferase 1","Uniprot":["Q5T8I9"],"Chromosome":"1","Position":"108648290-108661526","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing"],"Molecular function":["Methyltransferase","RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"67.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"71.6","Early primary spermatocytes":"150.0","Late primary spermatocytes":"181.4","Oocytes":"405.2","Undifferentiated spermatogonia":"119.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Oocytes":"405.2","Spermatogenic cell types":"181.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Plasma membrane","Focal adhesion sites"],"Subcellular additional location":null,"Antibody RRID":{"HPA028464":null,"HPA028497":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":null,"Subcellular main location":["Vesicles","Mitotic spindle"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA012381":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HERPUD2","Gene synonym":["FLJ22313"],"Ensembl":"ENSG00000122557","Gene description":"HERPUD family member 2","Uniprot":["Q9BSE4"],"Chromosome":"7","Position":"35632659-35697459","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Unfolded protein response"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"373.0","Late spermatids":"984.6","Neutrophils":"228.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"984.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":16,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":null,"Antibody RRID":{"HPA015630":null,"HPA076087":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.73e-6"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.48e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.80e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"HEXIM2","Gene synonym":["FLJ32384"],"Ensembl":"ENSG00000168517","Gene description":"HEXIM P-TEFb complex subunit 2","Uniprot":["Q96MH2"],"Chromosome":"17","Position":"45160700-45170040","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"43.5","testis":"32.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"164.0","Early spermatids":"131.7","Late primary spermatocytes":"169.2","Late spermatids":"426.1","Oocytes":"78.3","Platelets":"124.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"164.0","Platelets":"124.2","Spermatogenic cell types":"426.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":65,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA023323":null,"HPA028455":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.90e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA059673":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.51e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HHLA2","Gene synonym":["B7-H5","B7-H7","B7H7","B7y"],"Ensembl":"ENSG00000114455","Gene description":"HERV-H LTR-associating 2","Uniprot":["Q9UM44"],"Chromosome":"3","Position":"108296529-108378285","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"intestine":"129.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Colonocytes":"491.1","Enterocytes":"691.1","Respiratory ciliated cells":"234.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"234.1","Enterocytes":"691.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"11.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"49.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"2.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"12.4","Rhabdoid":"15.4"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055478":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"}},{"Gene":"HIGD2B","Gene synonym":["HIGD2BP"],"Ensembl":"ENSG00000175202","Gene description":"HIG1 hypoxia inducible domain family member 2B","Uniprot":["Q4VC39"],"Chromosome":"15","Position":"72675798-72686182","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"3.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early primary spermatocytes":"10.7","Early spermatids":"13.5","Late primary spermatocytes":"41.4","Late spermatids":"12.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"26","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"41.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1500000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":18,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA044577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.42e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":4,"Subcellular main location":["Nucleoli","Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA027914":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.74e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.62e-7"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"HIPK1","Gene synonym":["KIAA0630","MGC26642","MGC33446","MGC33548","Myak","Nbak2"],"Ensembl":"ENSG00000163349","Gene description":"Homeodomain interacting protein kinase 1","Uniprot":["Q86Z02"],"Chromosome":"1","Position":"113929324-113977869","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"134.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Fallopian tube ciliated cells":"293.5","Neutrophil progenitors":"548.7","Neutrophils":"470.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"548.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016664"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":8,"Subcellular main location":["Nucleoplasm","Basal body","Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA016664":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.55e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.47e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"}},{"Gene":"HIPK4","Gene synonym":["FLJ32818"],"Ensembl":"ENSG00000160396","Gene description":"Homeodomain interacting protein kinase 4","Uniprot":["Q8NE63"],"Chromosome":"19","Position":"40379271-40390181","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"brain":"9.0","testis":"17.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"40.5","Early spermatids":"78.1","Epididymal basal cells":"36.2","Late primary spermatocytes":"96.4","Late spermatids":"39.5","Myonuclei":"26.5","Oocytes":"64.5","Retinal ganglion cells":"27.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"36.2","Oocytes":"64.5","Secretory gland support":"40.5","Spermatogenic cell types":"96.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"34.3","medium spiny neuron":"35.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"192","Protein cell type specific Intensity":{"Collecting ducts":"11621.4","Distal tubules":"26841.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HIRIP3","Gene synonym":[],"Ensembl":"ENSG00000149929","Gene description":"HIRA interacting protein 3","Uniprot":["Q9BW71"],"Chromosome":"16","Position":"29992330-29996074","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"84.8","Late primary spermatocytes":"160.9","Megakaryocyte progenitors":"66.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"160.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"231452.6","T-cells":"535852.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"2644477.7"},"Antibody":["HPA051897","HPA063205"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA051897":null,"HPA063205":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"HJURP","Gene synonym":["DKFZp762E1312","FAKTS","hFLEG1","URLC9"],"Ensembl":"ENSG00000123485","Gene description":"Holliday junction recognition protein","Uniprot":["Q8NCD3"],"Chromosome":"2","Position":"233833416-233854566","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Chaperone","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"44.7","lymphoid tissue":"28.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"27.2","Early spermatids":"17.5","Enteric transient amplifying cells":"22.5","Erythrocyte progenitors":"53.1","Extravillous trophoblasts":"18.4","Gastric progenitor cells":"20.5","Late primary spermatocytes":"58.7","Megakaryocyte progenitors":"36.2","Monocyte progenitors":"65.5","Neutrophil progenitors":"24.7","Oocytes":"96.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"53.1","Megakaryocytes":"36.2","Mononuclear phagocytes":"65.5","Oocytes":"96.7","Spermatogenic cell types":"58.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"7526","Protein cell type specific Intensity":{"Capillaries":"898163.3","Glomeruli":"606937.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"3122355.3"},"Antibody":["HPA008436","HPA027261"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":24,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA008436":null,"HPA027261":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.25e-12"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.64e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"}},{"Gene":"HJV","Gene synonym":["haemojuvelin","hemojuvelin","HFE2","HFE2A","JH","RGMC"],"Ensembl":"ENSG00000168509","Gene description":"Hemojuvelin BMP co-receptor","Uniprot":["Q6ZVN8"],"Chromosome":"1","Position":"146017468-146036746","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"liver":"223.7","skeletal muscle":"553.9","tongue":"271.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Hepatocytes":"192.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Hepatocytes":"192.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"81","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"160.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"1.1"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"67000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HK1","Gene synonym":[],"Ensembl":"ENSG00000156515","Gene description":"Hexokinase 1","Uniprot":["P19367"],"Chromosome":"10","Position":"69269984-69401884","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Glycolysis","Immunity","Inflammatory response","Innate immunity"],"Molecular function":["Allosteric enzyme","Kinase","Transferase"],"Disease involvement":["Cancer-related genes","Charcot-Marie-Tooth disease","Disease variant","Hereditary hemolytic anemia","Intellectual disability","Neurodegeneration","Neuropathy","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"441.9","Late spermatids":"1797.7","Retinal horizontal cells":"717.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"717.2","Spermatogenic cell types":"1797.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2400000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":18,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB010052":null,"HPA007043":null,"HPA007044":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-6"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.43e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"}},{"Gene":"HK3","Gene synonym":[],"Ensembl":"ENSG00000160883","Gene description":"Hexokinase 3","Uniprot":["P52790"],"Chromosome":"5","Position":"176880869-176899346","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Glycolysis"],"Molecular function":["Allosteric enzyme","Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"122.3","lymphoid tissue":"72.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hofbauer cells":"35.9","Kupffer cells":"82.0","Late primary spermatocytes":"17.5","Macrophages":"18.2","Monocyte progenitors":"22.5","monocytes":"56.0","Neutrophil progenitors":"102.7","Neutrophils":"120.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"82.0","Neutrophils":"120.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"leukocyte":"14.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"571.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"571.4","monocytes":"201.4"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"Leukemia":"2.9","Neuroblastoma":"1.0"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2300000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056743":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.70e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HMBOX1","Gene synonym":["FLJ21616","HNF1LA","HOT1","PBHNF"],"Ensembl":"ENSG00000147421","Gene description":"Homeobox containing 1","Uniprot":["Q6NT76"],"Chromosome":"8","Position":"28890395-29064764","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"456.2","Pituicytes\/FSCs":"386.5","Renal collecting duct intercalated cells":"419.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":84,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"CAB070418":null,"HPA055855":null,"HPA058586":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.19e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"}},{"Gene":"HMCN1","Gene synonym":["ARMD1","FBLN6","FIBL-6","FIBL6"],"Ensembl":"ENSG00000143341","Gene description":"Hemicentin 1","Uniprot":["Q96RW7"],"Chromosome":"1","Position":"185734391-186190949","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Cell cycle","Cell division","Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Age-related macular degeneration","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"blood vessel":"66.0","lung":"19.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"132.6","Distal convoluted tubule cells":"252.6","Fibro-adipogenic progenitors":"371.7","Lacrimal acinar cells":"190.2","Lymphatic endothelial cells":"148.6","Melanocytes":"210.6","Pituicytes\/FSCs":"763.6","Retinal horizontal cells":"236.4","Salivary duct cells":"252.3","Schwann cells":"170.3","Transitional alveolar cells":"244.2","Vascular endothelial cells":"221.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Fibro-adipogenic progenitors":"371.7","Glial cells":"763.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"endothelial cell":"397.0"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"77.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"64.8","skin cancer":"50.9"},"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Colon - Enteric glia cells","Pancreas - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"olfactory bulb":"13.2"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"93354572.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"214184720.1","intestine":"114667667.9"},"Antibody":["HPA008220","HPA051677"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7400000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":1,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008220":null,"HPA051677":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.15e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.53e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"}},{"Gene":"HMCN2","Gene synonym":["DKFZp434P0216","FLJ23816"],"Ensembl":"ENSG00000148357","Gene description":"Hemicentin 2","Uniprot":["Q8NDA2"],"Chromosome":"9","Position":"130265760-130434123","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Sensory transduction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"endometrium 1":"21.4","intestine":"37.0","skeletal muscle":"23.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Fibro-adipogenic progenitors":"521.0","Myosatellite cells":"810.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Fibro-adipogenic progenitors":"521.0","Stem cells":"810.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"splatter":"17.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"pons":"9.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"5.4","Sarcoma":"3.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA053903":null,"HPA070647":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-6"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.60e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.01e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HMGA2","Gene synonym":["BABL","HMGIC","LIPO"],"Ensembl":"ENSG00000149948","Gene description":"High mobility group AT-hook 2","Uniprot":["P52926"],"Chromosome":"12","Position":"65824460-65966291","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Cell cycle","Cell division","DNA condensation","Growth regulation","Mitosis","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","Dwarfism","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"4.6","testis":"3.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial secretory cells":"167.9","Erythrocyte progenitors":"149.9","Granulosa cells":"85.2","Hematopoietic stem cells":"427.5","Megakaryocyte progenitors":"108.4","Megakaryocyte-Erythroid progenitors":"153.6","Pituicytes\/FSCs":"455.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"455.3","Secretory cells":"167.9","Stem cells":"427.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"11.4","deep-layer near-projecting":"30.0","ependymal cell":"18.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"236815.2","Granulosa cells":"168092.9","Oocytes":"85682.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"570241.6"},"Antibody":["CAB017809","HPA039076"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":23,"Subcellular main location":["Nucleoplasm","Nucleoli","Nucleoli rim"],"Subcellular additional location":null,"Antibody RRID":{"CAB017809":null,"HPA039076":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.74e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.00e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"}},{"Gene":"HMMR","Gene synonym":["CD168","RHAMM"],"Ensembl":"ENSG00000072571","Gene description":"Hyaluronan mediated motility receptor","Uniprot":["O75330"],"Chromosome":"5","Position":"163460203-163491941","Protein class":["CD markers","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"19.4","lymphoid tissue":"25.4","testis":"25.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"51.0","Differentiating spermatogonia":"46.8","Early primary spermatocytes":"47.6","Early spermatids":"72.2","Enteric transient amplifying cells":"64.6","Erythrocyte progenitors":"127.5","Extravillous trophoblasts":"65.0","Late primary spermatocytes":"171.3","Late spermatids":"96.8","Megakaryocyte progenitors":"115.9","Migrating cytotrophoblasts":"57.5","Monocyte progenitors":"155.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"127.5","Megakaryocytes":"115.9","Mononuclear phagocytes":"155.5","Spermatogenic cell types":"171.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2531","Protein cell type specific Intensity":{"Granulosa cells":"253070.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7133","Protein tissue specific Intensity":{"bone marrow":"713294.0"},"Antibody":["CAB002433","HPA040025","HPA043926","HPA061524"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Microtubules","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":27,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"CAB002433":null,"HPA040025":null,"HPA043926":null,"HPA061524":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.62e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.22e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.18e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.04e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.90e-10"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.47e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.79e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.82e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.43e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"}},{"Gene":"HNF1B","Gene synonym":["HNF1beta","LFB3","MODY5","TCF2","VHNF1"],"Ensembl":"ENSG00000275410","Gene description":"HNF1 homeobox B","Uniprot":["P35680"],"Chromosome":"17","Position":"37686431-37745059","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Diabetes mellitus","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"67.4","pancreas":"33.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"178.2","Loop of henle epithelial cells":"254.6","Papillary tip epithelial cells":"75.3","Proximal tubule cells":"132.2","Renal collecting duct intercalated cells":"195.6","Renal collecting duct principal cells":"170.1","Renal connecting tubule cells":"225.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ductal cells":"225.0","Renal nephron cells":"254.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"1.5"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"46.3","Kidney Renal Papillary Cell Carcinoma (TCGA)":"131.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"49.9"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB068192":null,"HPA002083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"HNF4A","Gene synonym":["HNF4","MODY","MODY1","NR2A1","TCF14"],"Ensembl":"ENSG00000101076","Gene description":"Hepatocyte nuclear factor 4 alpha","Uniprot":["P41235"],"Chromosome":"20","Position":"44355699-44432845","Protein class":["Disease related genes","Human disease related genes","Nuclear receptors","Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Receptor","Repressor"],"Disease involvement":["Diabetes mellitus","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"intestine":"96.1","kidney":"42.7","liver":"112.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"443.6","Enteric stem cells":"432.7","Enteric transient amplifying cells":"348.2","Enterocytes":"333.4","Foveolar cells":"210.3","Gastric progenitor cells":"182.0","Goblet cells":"235.7","Hepatocytes":"281.9","Neuroendocrine cells":"168.2","Paneth cells":"355.8","Proximal tubule cells":"216.9","Tuft cells":"196.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"443.6","Goblet cells":"235.7","Hepatocytes":"281.9","Proliferating cells":"348.2","Secretory gland support":"355.8","Stem cells":"432.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"30","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"43.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"117.4","Rectum Adenocarcinoma (TCGA)":"129.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"10","RNA brain regional specific nTPM":{"choroid plexus":"32.2"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Bile duct cancer":"19.2","colorectal cancer":"57.4","Gastric cancer":"33.3","liver cancer":"41.4"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":38,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB019417":null,"HPA004712":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"}},{"Gene":"HNF4G","Gene synonym":["NR2A2"],"Ensembl":"ENSG00000164749","Gene description":"Hepatocyte nuclear factor 4 gamma","Uniprot":["Q14541"],"Chromosome":"8","Position":"75407914-75566834","Protein class":["Nuclear receptors","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"intestine":"108.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"210.7","Colonocytes":"272.8","Enteric stem cells":"253.4","Enteric transient amplifying cells":"264.9","Enterocytes":"771.5","Foveolar cells":"168.7","Goblet cells":"290.7","Neuroendocrine cells":"197.9","Pancreatic acinar cells":"190.9","Paneth cells":"375.1","Proximal tubule cells":"156.0","Tuft cells":"172.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"771.5","Goblet cells":"290.7","Proliferating cells":"264.9","Secretory gland support":"375.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"79.3","Bergmann glia":"82.1","ependymal cell":"75.9","oligodendrocyte precursor cell":"42.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"17.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Gonadotropes","Prostate - Urothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"379","Protein cell type specific Intensity":{"Proximal tubules":"37921.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3982","Protein tissue specific Intensity":{"intestine":"398175.7"},"Antibody":["HPA005438","HPA010610"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytokinetic bridge","Mitotic spindle","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Cytosol"],"Antibody RRID":{"HPA005438":null,"HPA010610":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.30e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.67e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"HNRNPF","Gene synonym":["HNRPF"],"Ensembl":"ENSG00000169813","Gene description":"Heterogeneous nuclear ribonucleoprotein F","Uniprot":["P52597"],"Chromosome":"10","Position":"43385617-43409186","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016884","HPA069667"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"620000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":106,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA016884":null,"HPA069667":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"}},{"Gene":"HNRNPLL","Gene synonym":["HNRPLL"],"Ensembl":"ENSG00000143889","Gene description":"Heterogeneous nuclear ribonucleoprotein L like","Uniprot":["Q8WVV9"],"Chromosome":"2","Position":"38561969-38603586","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"222.9","Neutrophil progenitors":"529.9","Pituicytes\/FSCs":"310.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"310.0","Neutrophils":"529.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"26623211.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046084"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":22,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria","Cytosol"],"Antibody RRID":{"HPA046084":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.49e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"}},{"Gene":"HOATZ","Gene synonym":["C11orf88","FLJ46266"],"Ensembl":"ENSG00000183644","Gene description":"HOATZ cilia and flagella associated protein","Uniprot":["Q6PI97"],"Chromosome":"11","Position":"111514778-111537043","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"choroid plexus":"158.9","fallopian tube":"80.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"870.4","Epididymal efferent duct ciliated cells":"431.9","Fallopian tube ciliated cells":"1079.5","Late primary spermatocytes":"310.9","Respiratory ciliated cells":"1027.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"64","RNA single cell type group specific nCPM":{"Ciliated cells":"1079.5","Spermatogenic cell types":"310.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"235.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"14.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"68.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"5.2","Kidney cancer":"2.8"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"11.7"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"8858","Protein cell type specific Intensity":{"Fallopian tube cells":"885805.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"30220","Protein tissue specific Intensity":{"fallopian tube":"3021959.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.40e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.44e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"}},{"Gene":"HOOK1","Gene synonym":["HK1"],"Ensembl":"ENSG00000134709","Gene description":"Hook microtubule tethering protein 1","Uniprot":["Q9UJC3"],"Chromosome":"1","Position":"59814786-59876322","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Protein transport","Spermatogenesis","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"46.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"786.4","Late spermatids":"1305.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1305.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"6.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Colon enterocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary gland basal cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"22359937.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"34795775.7"},"Antibody":["HPA018537","HPA018820"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":58,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018537":null,"HPA018820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"HPA003074":null,"HPA043880":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"}},{"Gene":"HOXA3","Gene synonym":["HOX1","HOX1E"],"Ensembl":"ENSG00000105997","Gene description":"Homeobox A3","Uniprot":["O43365"],"Chromosome":"7","Position":"27106184-27152583","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct absorptive cells":"41.7","Hematopoietic stem cells":"43.7","Late spermatids":"92.4","Loop of henle epithelial cells":"62.5","Renal connecting tubule cells":"65.2","Tuft cells":"57.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"65.2","Renal nephron cells":"62.5","Secretory gland support":"57.6","Spermatogenic cell types":"92.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"10.2","lower rhombic lip":"21.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"33.4"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"19","RNA brain regional specific nTPM":{"medulla oblongata":"22.4","pons":"16.4","spinal cord":"19.8","white matter":"14.6"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"}},{"Gene":"HOXA5","Gene synonym":["HOX1","HOX1C"],"Ensembl":"ENSG00000106004","Gene description":"Homeobox A5","Uniprot":["P20719"],"Chromosome":"7","Position":"27141052-27143681","Protein class":["Cancer-related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"77.6","epididymis":"46.2","fallopian tube":"55.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"2.5","Basal prostatic cells":"3.9","Breast lactating cells":"1.5","Breast myoepithelial cells":"4.3","Epididymal efferent duct absorptive cells":"2.5","Epididymal principal cells":"1.1","Fibroblasts":"1.4","Hematopoietic stem cells":"1.9","Innate lymphoid cells":"2.2","Prostatic club cells":"1.1","Smooth muscle cells":"1.6","Thymic myoid cells":"1.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"2.5","Basal cells":"3.9","Ductal cells":"2.5","Secretory gland support":"4.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"46","RNA brain regional specific nTPM":{"medulla oblongata":"84.5","pons":"22.5","spinal cord":"52.7","white matter":"35.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"220","RNA mouse brain regional specific nTPM":{"pons and medulla":"22.0"},"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":"33","RNA pig brain regional specific nTPM":{"medulla oblongata":"5.7","spinal cord":"21.4"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"234061.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"95","Protein tissue specific Intensity":{"lung":"9490.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"}},{"Gene":"HOXD8","Gene synonym":["HOX4","HOX4E"],"Ensembl":"ENSG00000175879","Gene description":"Homeobox D8","Uniprot":["P13378"],"Chromosome":"2","Position":"176129694-176132695","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"94.1","kidney":"71.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"82.0","Early primary spermatocytes":"52.2","Early spermatids":"94.5","Epididymal efferent duct absorptive cells":"52.8","Epididymal efferent duct ciliated cells":"55.8","Epididymal principal cells":"143.1","Fallopian tube ciliated cells":"39.5","Late primary spermatocytes":"166.0","Leydig cells":"39.4","Lymphatic endothelial cells":"87.5","Peritubular myoid cells":"47.5","Renal connecting tubule cells":"47.0","Vascular endothelial cells":"35.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Endothelial cells":"87.5","Renal nephron cells":"82.0","Reproductive supporting cells":"143.1","Spermatogenic cell types":"166.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"40.2"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"11","RNA brain regional specific nTPM":{"medulla oblongata":"3.3","spinal cord":"8.6","white matter":"12.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"27.5"},"RNA tissue cell type enrichment":["Breast - Endothelial cells","Minor Salivary Gland - Endothelial cells","Prostate - Endothelial cells","Spleen - Endothelial cells","Stomach - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"71","RNA pig brain regional specific nTPM":{"spinal cord":"45.9"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"6188","Protein cell type specific Intensity":{"Collecting ducts":"806418.3","Distal tubules":"622307.0","Fallopian tube cells":"427649.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.81e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.21e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.82e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"HPSE2","Gene synonym":["HPA2","HPR2","UFS"],"Ensembl":"ENSG00000172987","Gene description":"Heparanase 2 (inactive)","Uniprot":["Q8WWQ2"],"Chromosome":"10","Position":"98457077-99235862","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"28.1","cervix":"29.6","vagina":"21.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"295.5","Astrocytes":"1765.3","Early primary spermatocytes":"386.7","Endometrial stromal cells":"759.1","Ependymal cells":"688.3","Melanocytes":"245.2","Pituicytes\/FSCs":"232.7","Smooth muscle cells":"330.2","Undifferentiated spermatogonia":"190.4","Vascular smooth muscle cells":"189.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"688.3","Glial cells":"1765.3","Stromal cells":"759.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"astrocyte":"2414.9","ependymal cell":"844.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"6.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Leukemia":"7.4","prostate cancer":"2.1"},"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044603":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - 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Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023004","HPA023393","HPA024430"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":5,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA023004":null,"HPA023393":null,"HPA024430":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.97e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.26e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.43e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA064126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"}},{"Gene":"HSBP1","Gene synonym":[],"Ensembl":"ENSG00000230989","Gene description":"Heat shock factor binding protein 1","Uniprot":["O75506"],"Chromosome":"16","Position":"83719311-83819737","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct ciliated cells":"381.1","Esophageal apical cells":"1104.8","Esophageal suprabasal cells":"385.0","Late primary spermatocytes":"854.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1104.8","Spermatogenic cell types":"854.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":31,"Subcellular main location":["Nuclear speckles","Plasma membrane"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA006121":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.57e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.21e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"}},{"Gene":"HSF1","Gene synonym":["HSTF1"],"Ensembl":"ENSG00000185122","Gene description":"Heat shock transcription factor 1","Uniprot":["Q00613"],"Chromosome":"8","Position":"144291591-144314720","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["DNA damage","DNA repair","Host-virus interaction","mRNA processing","mRNA transport","Stress response","Transcription","Transcription regulation","Transport"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"20.0","Bergmann glia":"22.5","Brain excitatory neurons":"19.6","Choroid plexus epithelial cells":"30.2","Distal convoluted tubule cells":"41.8","Ependymal cells":"21.0","Loop of henle epithelial cells":"36.4","Microglia":"25.7","Oligodendrocytes":"21.8","Other brain neurons":"23.1","Papillary tip epithelial cells":"44.9","Podocytes":"29.2","Proximal tubule cells":"34.1","Renal collecting duct intercalated cells":"45.6","Renal collecting duct principal cells":"45.4","Renal connecting tubule cells":"46.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"30.2","Ductal cells":"46.5","Glial cells":"25.7","Neuronal cells":"23.1","Renal nephron cells":"44.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"8252894.5","Macrophages":"5994415.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1603015.0","fallopian tube":"1102261.7","intestine":"2239642.1","liver":"1417841.2"},"Antibody":["CAB004239","HPA008888"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":117,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB004239":null,"HPA008888":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.74e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.53e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"}},{"Gene":"HSF2BP","Gene synonym":["MEILB2"],"Ensembl":"ENSG00000160207","Gene description":"Heat shock transcription factor 2 binding protein","Uniprot":["O75031"],"Chromosome":"21","Position":"43529186-43659488","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Premature ovarian failure"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"22.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"45.8","Early primary spermatocytes":"87.5","Early spermatids":"107.0","Late primary spermatocytes":"48.3","Late spermatids":"45.3","Retinal ganglion cells":"23.2","Undifferentiated spermatogonia":"30.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"107.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"19.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":232,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA031724":null,"HPA075775":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.78e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.08e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"}},{"Gene":"HSF5","Gene synonym":["FLJ40311"],"Ensembl":"ENSG00000176160","Gene description":"Heat shock transcription factor 5","Uniprot":["Q4G112"],"Chromosome":"17","Position":"58420167-58488408","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Meiosis","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"41","RNA tissue specific nTPM":{"testis":"45.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"50.3","Early spermatids":"35.5","Hematopoietic stem cells":"25.2","Late primary spermatocytes":"135.2","Late spermatids":"17.0","Megakaryocyte-Erythroid progenitors":"16.7","pDCs":"26.5","Retinal ganglion cells":"27.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"135.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"1.3","T-cells":"1.1"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016440","HPA063613"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA016440":null,"HPA063613":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"89000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":133,"Subcellular main location":["Vesicles","Flagellar centriole","Annulus"],"Subcellular additional location":["Perinuclear theca","Calyx"],"Antibody RRID":{"HPA000798":null,"HPA052504":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"}},{"Gene":"HSPA4L","Gene synonym":["APG-1","HSPH3","Osp94"],"Ensembl":"ENSG00000164070","Gene description":"Heat shock protein family A (Hsp70) member 4 like","Uniprot":["O95757"],"Chromosome":"4","Position":"127781821-127840733","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"101.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"539.2","Late primary spermatocytes":"409.6","Late spermatids":"1609.1","Pancreatic duct cells":"240.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1609.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"1.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"640000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":41,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome","Perinuclear theca","Calyx"],"Antibody RRID":{"CAB034450":null,"HPA039149":null,"HPA061446":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.32e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.64e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"HSPB7","Gene synonym":["cvHSP"],"Ensembl":"ENSG00000173641","Gene description":"Heat shock protein family B (small) member 7","Uniprot":["Q9UBY9"],"Chromosome":"1","Position":"16014028-16019594","Protein class":["Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"3567.7","skeletal muscle":"2065.4","tongue":"1148.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"493.7","Late spermatids":"129.5","Myonuclei":"231.9","Smooth muscle cells":"81.1","Thymic myoid cells":"581.9","Vascular smooth muscle cells":"76.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"493.7","Stromal cells":"581.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"pericyte":"9.2","vascular associated smooth muscle cell":"26.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"33.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"15.8","Brain cancer":"8.8","thyroid cancer":"8.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Lung - Smooth muscle cells","Prostate - Smooth muscle cells","Spleen - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"99493019.0","Skeletal myofibers":"225439492.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1690094305.3","skeletal muscle":"1757425677.4"},"Antibody":["HPA027639"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"50000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA027639":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.53e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"HSPB9","Gene synonym":["CT51"],"Ensembl":"ENSG00000260325","Gene description":"Heat shock protein family B (small) member 9","Uniprot":["Q9BQS6"],"Chromosome":"17","Position":"42122804-42123352","Protein class":["Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"65.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1561.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"86","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1561.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"5.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053091"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA053091":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HSPBAP1","Gene synonym":["FLJ22623","PASS1"],"Ensembl":"ENSG00000169087","Gene description":"HSPB1 associated protein 1","Uniprot":["Q96EW2"],"Chromosome":"3","Position":"122739999-122793831","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Microglia":"153.5","Myonuclei":"151.2","Neutrophils":"343.5","Syncytiotrophoblasts":"108.4","Thymic myoid cells":"110.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"343.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"197.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":8,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA044930":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":6,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA006417":null,"HPA024321":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.40e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.72e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB017467":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HTR7","Gene synonym":["5-HT7"],"Ensembl":"ENSG00000148680","Gene description":"5-hydroxytryptamine receptor 7","Uniprot":["P34969"],"Chromosome":"10","Position":"90740823-90858039","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"parathyroid gland":"12.3","testis":"8.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"23.4","Brain inhibitory neurons":"19.7","cDC":"42.1","Hepatic stellate cells":"45.2","Hofbauer cells":"15.0","Late primary spermatocytes":"21.6","Macrophages":"30.1","monocytes":"16.0","Other brain neurons":"25.0","Undifferentiated spermatogonia":"25.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"dendritic cells":"42.1","Mononuclear phagocytes":"30.1","Neuronal cells":"25.0","Spermatogenic cell types":"25.7","Stellate cells":"45.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"134.7","mammillary body":"335.5"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"3.1","Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"2.5","Head and Neck Squamous Cell Carcinoma (TCGA)":"5.0","Lung Squamous Cell Carcinoma (TCGA)":"2.5","Testicular Germ Cell Tumor (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"myeloid DC":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"dendritic cells":"1.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Vesicles","Primary cilium"],"Antibody RRID":{"CAB080587":null,"HPA065367":null,"HPA073617":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"HVCN1","Gene synonym":["Hv1","MGC15619","VSOP"],"Ensembl":"ENSG00000122986","Gene description":"Hydrogen voltage gated channel 1","Uniprot":["Q96D96"],"Chromosome":"12","Position":"110627841-110704950","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Fertilization","Hydrogen ion transport","Immunity","Innate immunity","Ion transport","Transport"],"Molecular function":["Ion channel","Voltage-gated channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"choroid plexus":"505.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"209.1","Cardiomyocytes":"105.0","Choroid plexus epithelial cells":"294.4","Early spermatids":"94.6","Late primary spermatocytes":"217.4","Late spermatids":"100.7","Oocytes":"368.4","pDCs":"118.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"209.1","Ciliated cells":"294.4","Oocytes":"368.4","Spermatogenic cell types":"217.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"264.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"choroid plexus":"319.2"},"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"14","RNA cell line specific nTPM":{"Leukemia":"33.4","lymphoma":"48.2","Myeloma":"30.4"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039329":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"}},{"Gene":"HYCC1","Gene synonym":["DRCTNNB1A","FAM126A","HCC","hyccin"],"Ensembl":"ENSG00000122591","Gene description":"Hyccin PI4KA lipid kinase complex subunit 1","Uniprot":["Q9BYI3"],"Chromosome":"7","Position":"22889371-23014130","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cataract","Disease variant","Leukodystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"252.8","Esophageal apical cells":"248.7","Melanocytes":"257.2","Pituicytes\/FSCs":"570.7","Retinal pigment epithelial cells":"264.3","Schwann cells":"248.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"570.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"324.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Fibroblasts","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"1498605.6","Cardiomyocytes":"969113.3","Skeletal myofibers":"2442560.5","Smooth muscle cells":"2735448.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"2664955.7"},"Antibody":["HPA042873"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":12,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042873":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.47e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.27e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"}},{"Gene":"HYDIN","Gene synonym":["CILD5","DKFZp434D0513","KIAA1864","PPP1R31"],"Ensembl":"ENSG00000157423","Gene description":"HYDIN axonemal central pair apparatus protein","Uniprot":["Q4G0P3"],"Chromosome":"16","Position":"70802084-71230722","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"5.0","retina":"6.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"620.2","Endometrial ciliated cells":"524.9","Ependymal cells":"1646.9","Epididymal efferent duct ciliated cells":"529.2","Fallopian tube ciliated cells":"563.0","Respiratory ciliated cells":"1047.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"1646.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"500.8","ependymal cell":"1758.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"24733020.2","Neutrophils":"17889298.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"2349966.3","bone marrow":"4344167.9","intestine":"6919540.7","lung":"3514139.6"},"Antibody":["HPA046282","HPA067155"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytokinetic bridge","Mitotic spindle","Primary cilium","Cytosol","Equatorial segment"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Cytokinetic bridge","Primary cilium","Cytosol","Equatorial segment"],"Subcellular additional location":["Nucleoplasm","Mitotic spindle"],"Antibody RRID":{"HPA046282":null,"HPA067155":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.10e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"}},{"Gene":"HYKK","Gene synonym":["AGPHD1","LOC123688"],"Ensembl":"ENSG00000188266","Gene description":"Hydroxylysine kinase","Uniprot":["A2RU49"],"Chromosome":"15","Position":"78507564-78537372","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"44.5","Late spermatids":"51.7","Myosatellite cells":"68.5","Respiratory basal cells":"33.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"44.5","Spermatogenic cell types":"51.7","Stem cells":"68.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"3.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"T-cells":"3.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"222278.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040706"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Aggresome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":2,"Subcellular main location":["Nucleoplasm","Vesicles","Aggresome","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040706":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.95e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"HYLS1","Gene synonym":["FLJ32915"],"Ensembl":"ENSG00000198331","Gene description":"HYLS1 centriolar and ciliogenesis associated","Uniprot":["Q96M11"],"Chromosome":"11","Position":"125883614-125900646","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"24.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"67.7","Early spermatids":"136.4","Late primary spermatocytes":"119.1","Late spermatids":"82.5","Oocytes":"128.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Oocytes":"128.9","Spermatogenic cell types":"136.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Mitotic cells (Skin)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"401","Protein cell type specific Intensity":{"Fallopian tube cells":"40148.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041210"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041210":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.21e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"}},{"Gene":"HYOU1","Gene synonym":["Grp170","HSP12A","ORP150"],"Ensembl":"ENSG00000149428","Gene description":"Hypoxia up-regulated 1","Uniprot":["Q9Y4L1"],"Chromosome":"11","Position":"119044188-119057227","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Stress response"],"Molecular function":["Chaperone"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"35.9","Early spermatids":"34.9","Late spermatids":"29.9","Other brain neurons":"30.0","Plasma cells":"36.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"35.9","Plasma cells":"36.5","Spermatogenic cell types":"34.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Macrophages","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"277905567.5","Pancreas epithelial cells":"621080363.4","Pancreatic islets":"801106655.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"408049415.4"},"Antibody":["HPA049296"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"59000000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 78: Plasma cells - Antibody production & ER-stress response","Interactions":54,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049296":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.25e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.86e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"}},{"Gene":"IAH1","Gene synonym":[],"Ensembl":"ENSG00000134330","Gene description":"Isoamyl acetate hydrolyzing esterase 1 (putative)","Uniprot":["Q2TAA2"],"Chromosome":"2","Position":"9473658-9496543","Protein class":["Predicted intracellular proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"419.8","Epicardial cells":"370.7","Late primary spermatocytes":"542.3","Late spermatids":"756.6","Oocytes":"718.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"370.7","Oocytes":"718.4","Spermatogenic cell types":"756.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040523","HPA076040"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"120000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA040523":null,"HPA076040":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.45e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.87e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.14e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"}},{"Gene":"IAPP","Gene synonym":["AMYLIN","DAP","IAP"],"Ensembl":"ENSG00000121351","Gene description":"Islet amyloid polypeptide","Uniprot":["P10997"],"Chromosome":"12","Position":"21354959-21379980","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"54","RNA tissue specific nTPM":{"pancreas":"157.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"42","RNA single cell type specific nCPM":{"Pancreatic islet cells":"1972.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"42","RNA single cell type group specific nCPM":{"Pancreatic islet cells":"1972.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"endothelial cell":"1.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"40","RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"36.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"2.4","thyroid cancer":"1.6"},"RNA tissue cell type enrichment":["Pancreas - Beta cells","Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"61104","Protein cell type specific Intensity":{"Capillaries":"3938038.8","Fallopian tube cells":"8282706.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB000352","HPA053194"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":"Secreted to blood","Secretome function":"Hormone","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":606000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB000352":null,"HPA053194":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA030555":null,"HPA030556":null,"HPA030557":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":8,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017646":null,"HPA061452":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"}},{"Gene":"IDE","Gene synonym":[],"Ensembl":"ENSG00000119912","Gene description":"Insulin degrading enzyme","Uniprot":["P14735"],"Chromosome":"10","Position":"92451684-92574096","Protein class":["Enzymes","FDA approved drug targets","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["Allosteric enzyme","Host cell receptor for virus entry","Hydrolase","Metalloprotease","Protease","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"330000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA063478":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"}},{"Gene":"IFT122","Gene synonym":["FAP80","SPG","WDR10","WDR10p","WDR140"],"Ensembl":"ENSG00000163913","Gene description":"Intraflagellar transport 122","Uniprot":["Q9HBG6"],"Chromosome":"3","Position":"129429607-129520510","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Developmental protein"],"Disease involvement":["Ciliopathy","Disease variant","Ectodermal dysplasia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"44.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"275.9","Early primary spermatocytes":"212.7","Early spermatids":"175.7","Ependymal cells":"152.2","Late primary spermatocytes":"164.0","Late spermatids":"231.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"275.9","Spermatogenic cell types":"231.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":25,"Subcellular main location":["Primary cilium transition zone","Cytosol","Mid piece"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA041815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.53e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.15e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"IFT140","Gene synonym":["gs114","KIAA0590","WDTC2"],"Ensembl":"ENSG00000187535","Gene description":"Intraflagellar transport 140","Uniprot":["Q96RY7"],"Chromosome":"16","Position":"1510427-1612072","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"97.3","Respiratory ciliated cells":"144.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"144.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"3.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"57366024.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"10631311.8"},"Antibody":["HPA042197"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":32,"Subcellular main location":["Basal body"],"Subcellular additional location":["Nucleoplasm","Mitochondria"],"Antibody RRID":{"HPA042197":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-4"}},{"Gene":"IFT172","Gene synonym":["BBS20","NPHP17","osm-1","SLB","wim"],"Ensembl":"ENSG00000138002","Gene description":"Intraflagellar transport 172","Uniprot":["Q9UG01"],"Chromosome":"2","Position":"27444377-27489805","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Obesity","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"659.7","Late spermatids":"924.8","Respiratory ciliated cells":"290.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"290.5","Spermatogenic cell types":"924.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"40460479.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"8335027.4","lymphoid tissue":"6140459.6"},"Antibody":["HPA044893"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":46,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044893":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.02e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.03e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"}},{"Gene":"IFT20","Gene synonym":[],"Ensembl":"ENSG00000109083","Gene description":"Intraflagellar transport 20","Uniprot":["Q8IY31"],"Chromosome":"17","Position":"28328325-28335489","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"212.5","Early spermatids":"254.5","Late primary spermatocytes":"245.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"254.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":73,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Mitotic spindle","Basal body","Flagellar centriole","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA021376":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"}},{"Gene":"IFT22","Gene synonym":["DKFZp761N0823","FAP9","FLJ13225","FLJ14117","RABL5"],"Ensembl":"ENSG00000128581","Gene description":"Intraflagellar transport 22","Uniprot":["Q9H7X7"],"Chromosome":"7","Position":"101310914-101321823","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"69.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"521.4","Epididymal efferent duct ciliated cells":"293.0","Fallopian tube ciliated cells":"310.8","Late primary spermatocytes":"776.8","Late spermatids":"2180.3","Respiratory ciliated cells":"286.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2180.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"3241668.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"5902479.6","lung":"4929654.3"},"Antibody":["HPA042930"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Mitotic spindle","Primary cilium","Basal body","Cytosol","Flagellar centriole","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":56,"Subcellular main location":["Microtubules","Cytosol"],"Subcellular additional location":["Mitotic spindle","Primary cilium","Basal body","Flagellar centriole","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA042930":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.35e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"}},{"Gene":"IFT27","Gene synonym":["BBS19","FAP156","RABL4","RAYL"],"Ensembl":"ENSG00000100360","Gene description":"Intraflagellar transport 27","Uniprot":["Q9BW83"],"Chromosome":"22","Position":"36758202-36776256","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Differentiation","Protein transport","Spermatogenesis","Transport"],"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"127.1","Epididymal efferent duct ciliated cells":"316.5","Fallopian tube ciliated cells":"278.1","Late primary spermatocytes":"137.9","Respiratory ciliated cells":"306.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"316.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"141.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"6108966.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"6490310.8","Stomach":"1643251.8"},"Antibody":["HPA048791"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":45,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.70e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"}},{"Gene":"IFT43","Gene synonym":["C14orf179","FLJ32173","MGC16028"],"Ensembl":"ENSG00000119650","Gene description":"Intraflagellar transport 43","Uniprot":["Q96FT9"],"Chromosome":"14","Position":"75902136-76084585","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Ectodermal dysplasia","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Fallopian tube ciliated cells":"383.0","Respiratory ciliated cells":"366.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"383.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2545844.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"22081","Protein tissue specific Intensity":{"fallopian tube":"2208052.3"},"Antibody":["HPA003438"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle","Primary cilium","Centriolar satellite","Basal body","Perinuclear theca","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":27,"Subcellular main location":["Microtubules","Primary cilium","Principal piece","End piece"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Centriolar satellite","Basal body","Perinuclear theca"],"Antibody RRID":{"HPA003438":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"}},{"Gene":"IFT57","Gene synonym":["ESRRBL1","FLJ10147","HIPPI","MHS4R2"],"Ensembl":"ENSG00000114446","Gene description":"Intraflagellar transport 57","Uniprot":["Q9NWB7"],"Chromosome":"3","Position":"108160812-108222435","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Apoptosis","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Ciliopathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1871.3","Epididymal efferent duct ciliated cells":"472.6","Fallopian tube ciliated cells":"599.9","Late primary spermatocytes":"901.9","Late spermatids":"3984.0","Respiratory ciliated cells":"798.6","Transitional alveolar cells":"526.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3984.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"155.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"42.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"7301922.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"24300031.3"},"Antibody":["HPA035514","HPA035515"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Primary cilium","Primary cilium transition zone","Centriolar satellite","Basal body","Cytosol","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":68,"Subcellular main location":["Golgi apparatus","Primary cilium","Basal body","Mid piece"],"Subcellular additional location":["Primary cilium transition zone","Centriolar satellite","Cytosol"],"Antibody RRID":{"HPA035514":null,"HPA035515":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"}},{"Gene":"IFT74","Gene synonym":["CCDC2","CMG-1","CMG1","FLJ22621"],"Ensembl":"ENSG00000096872","Gene description":"Intraflagellar transport 74","Uniprot":["Q96LB3"],"Chromosome":"9","Position":"26947039-27066134","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Developmental protein"],"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Joubert syndrome","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"425.8","Respiratory ciliated cells":"242.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"425.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":50,"Subcellular main location":["Golgi apparatus","Centriolar satellite","Basal body"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020247":null,"HPA026684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"}},{"Gene":"IFT81","Gene synonym":["CDV-1R","CDV1","MGC4027"],"Ensembl":"ENSG00000122970","Gene description":"Intraflagellar transport 81","Uniprot":["Q8WYA0"],"Chromosome":"12","Position":"110124335-110218793","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"184.2","Early primary spermatocytes":"243.9","Ependymal cells":"194.2","Fallopian tube ciliated cells":"218.9","Respiratory ciliated cells":"287.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"287.7","Spermatogenic cell types":"243.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"215.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":45,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Primary cilium","Centrosome","Basal body"],"Antibody RRID":{"HPA019087":null,"HPA020051":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"}},{"Gene":"IFT88","Gene synonym":["D13S1056E","hTg737","MGC26259","Tg737","TTC10"],"Ensembl":"ENSG00000032742","Gene description":"Intraflagellar transport 88","Uniprot":["Q13099"],"Chromosome":"13","Position":"20567138-20691444","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"65.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"375.3","Ependymal cells":"505.2","Late primary spermatocytes":"332.7","Respiratory ciliated cells":"454.2","Rod photoreceptor cells":"390.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"505.2","Neuronal cells":"390.2","Spermatogenic cell types":"375.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"558.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"19746931.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"1811302.7","ovary":"5194437.6"},"Antibody":["HPA078625"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle","Primary cilium","Centriolar satellite","Basal body","Connecting piece","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":49,"Subcellular main location":["Microtubules","Primary cilium","End piece"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Centriolar satellite","Basal body","Connecting piece","Mid piece","Principal piece"],"Antibody RRID":{"HPA078625":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.29e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"}},{"Gene":"IFTAP","Gene synonym":["C11orf74","FLJ38678","HEPIS","NWC"],"Ensembl":"ENSG00000166352","Gene description":"Intraflagellar transport associated protein","Uniprot":["Q86VG3"],"Chromosome":"11","Position":"36594369-36675695","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"255.0","Early spermatids":"162.4","Epididymal efferent duct ciliated cells":"160.7","Fallopian tube ciliated cells":"184.6","Late primary spermatocytes":"332.3","Late spermatids":"242.6","Respiratory ciliated cells":"186.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"255.0","Spermatogenic cell types":"332.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"197.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"109295.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044880"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Aggresome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Aggresome"],"Antibody RRID":{"HPA044880":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"}},{"Gene":"IGBP1P2","Gene synonym":[],"Ensembl":"ENSG00000266826","Gene description":"Immunoglobulin (CD79A) binding protein 1 pseudogene 2","Uniprot":[],"Chromosome":"17","Position":"58660424-58692045","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"32","RNA tissue specific nTPM":{"testis":"8.3"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":null,"Protein cell type distribution":null,"Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":null,"Protein tissue distribution":null,"Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA000634","HPA001004"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Primary cilium","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":null,"Interactions":null,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Cytokinetic bridge","Basal body"],"Antibody RRID":{"HPA000634":null,"HPA001004":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IGF2BP2","Gene synonym":["IMP-2","p62"],"Ensembl":"ENSG00000073792","Gene description":"Insulin like growth factor 2 mRNA binding protein 2","Uniprot":["Q9Y6M1"],"Chromosome":"3","Position":"185643130-185825042","Protein class":["Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA transport","Translation regulation","Transport"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"863.1","Endometrial glandular cells":"803.4","Endometrial luminal cells":"1276.8","Endometrial secretory cells":"726.3","Rod photoreceptor cells":"512.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"863.1","Glandular cells":"803.4","Luminal cells":"1276.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"93.2","endothelial cell":"91.7","upper rhombic lip":"109.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"2.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Endothelial cells","Prostate - Fibroblasts","Spleen - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"40598943.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"7636592.3"},"Antibody":["CAB017126","HPA035145"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":56,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB017126":null,"HPA035145":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.28e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.38e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.24e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.15e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.04e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"IGF2BP3","Gene synonym":["CT98","IMP-3","IMP3"],"Ensembl":"ENSG00000136231","Gene description":"Insulin like growth factor 2 mRNA binding protein 3","Uniprot":["O00425"],"Chromosome":"7","Position":"23310209-23470491","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA transport","Translation regulation","Transport"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"6.9","placenta":"27.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"295.3","Esophageal apical cells":"143.8","Extravillous trophoblasts":"348.8","Gastric progenitor cells":"125.6","Hofbauer cells":"186.9","Megakaryocytes":"74.2","Migrating cytotrophoblasts":"213.1","Oocytes":"78.3","Platelets":"278.4","Syncytiotrophoblasts":"240.3","Undifferentiated spermatogonia":"74.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"143.8","Mononuclear phagocytes":"186.9","Platelets":"278.4","Proliferating cells":"125.6","Trophoblast cells":"348.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"23.7","LAMP5-LHX6 and Chandelier":"38.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"136110153.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"93","Protein tissue specific Intensity":{"skin":"9295.2"},"Antibody":["HPA002037","HPA076951"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6900","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":122,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA002037":null,"HPA076951":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.81e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.08e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.24e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.63e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.15e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"}},{"Gene":"IGFL2","Gene synonym":["UNQ645"],"Ensembl":"ENSG00000204866","Gene description":"IGF like family member 2","Uniprot":["Q6UWQ7"],"Chromosome":"19","Position":"46143106-46161298","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"skin 1":"39.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"2.8","Decidual stromal cells":"3.1","Differentiating spermatogonia":"6.8","Early primary spermatocytes":"7.2","Early spermatids":"6.2","Enteric transient amplifying cells":"2.5","Esophageal suprabasal cells":"2.6","Late primary spermatocytes":"7.1","Late spermatids":"6.8","Mesothelial cells":"2.4","Migrating cytotrophoblasts":"4.7","Retinal ganglion cells":"3.9","Suprabasal keratinocytes":"9.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"3.9","Spermatogenic cell types":"7.2","Suprabasal cells":"9.2","Trophoblast cells":"4.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"35.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Rhabdoid":"102.4"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA059137":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IGHMBP2","Gene synonym":["CATF1","CMT2S","HCSA","HMN6","SMARD1","SMUBP2","ZFAND7"],"Ensembl":"ENSG00000132740","Gene description":"Immunoglobulin mu DNA binding protein 2","Uniprot":["P38935"],"Chromosome":"11","Position":"68903863-68940602","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Helicase","Hydrolase","Ribonucleoprotein","RNA-binding","tRNA-binding"],"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"89.3","Late primary spermatocytes":"119.7","Late spermatids":"60.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"119.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"898273.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"127880.1","Stomach":"251907.5"},"Antibody":["HPA058367","HPA060994"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA058367":null,"HPA060994":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"}},{"Gene":"IGLL1","Gene synonym":["14.1","CD179B","IGL5","IGLL","IGVPB"],"Ensembl":"ENSG00000128322","Gene description":"Immunoglobulin lambda like polypeptide 1","Uniprot":["P15814"],"Chromosome":"22","Position":"23573125-23580302","Protein class":["CD markers","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"66.3","testis":"24.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"98.1","Late primary spermatocytes":"57.6","Late spermatids":"274.4","Neutrophil progenitors":"18.7","Thymocytes":"116.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"274.4","T-cells":"116.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"3.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"3.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"memory B-cell":"12.0","naive B-cell":"14.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"B-cells":"14.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"13","RNA cell line specific nTPM":{"Leukemia":"379.0","lymphoma":"146.4"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1200000000","Blood expression cluster":"Cluster 17: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA051134":null,"HPA071406":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IGLV3-21","Gene synonym":[],"Ensembl":"ENSG00000211662","Gene description":"Immunoglobulin lambda variable 3-21","Uniprot":["P80748"],"Chromosome":"22","Position":"22711689-22713203","Protein class":["Immunoglobulin genes","Predicted secreted proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"1697.1","urinary bladder":"725.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Plasma cells":"83.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Plasma cells":"83.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"337","RNA blood cell specific nTPM":{"memory B-cell":"433.3","naive B-cell":"225.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"444","RNA blood lineage specific nTPM":{"B-cells":"433.3"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"15","RNA cell line specific nTPM":{"Myeloma":"691.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA046377":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":66,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA045690":null,"HPA069534":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"}},{"Gene":"IK","Gene synonym":["RED","RER"],"Ensembl":"ENSG00000113141","Gene description":"IK cytokine","Uniprot":["Q13123"],"Chromosome":"5","Position":"140647058-140662480","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"373.9","Endometrial ciliated cells":"508.0","Epididymal efferent duct ciliated cells":"448.7","Esophageal apical cells":"432.1","Fallopian tube ciliated cells":"913.2","Late primary spermatocytes":"731.6","Oocytes":"359.2","Respiratory ciliated cells":"651.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"913.2","Spermatogenic cell types":"731.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":61,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA048798":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.45e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.27e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":157,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA024377":null,"HPA073266":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.02e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.07e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"}},{"Gene":"IKZF4","Gene synonym":["Eos","ZNFN1A4"],"Ensembl":"ENSG00000123411","Gene description":"IKAROS family zinc finger 4","Uniprot":["Q9H2S9"],"Chromosome":"12","Position":"56007659-56038435","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"T-reg":"1.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"T-cells":"1.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046270","HPA049016"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":14,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA046270":null,"HPA049016":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"}},{"Gene":"IL12RB2","Gene synonym":[],"Ensembl":"ENSG00000081985","Gene description":"Interleukin 12 receptor subunit beta 2","Uniprot":["Q99665"],"Chromosome":"1","Position":"67307364-67398724","Protein class":["Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"6.2","skeletal muscle":"3.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"116.0","Epididymal basal cells":"56.9","Hematopoietic stem cells":"104.8","Hofbauer cells":"63.4","Innate lymphoid cells":"84.7","Medullary thymic epithelial cells":"79.2","Myonuclei":"141.7","NK-cells":"355.6","T-cells":"135.9","Thymic myoid cells":"57.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"141.7","NK-cells":"355.6","T-cells":"135.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA1-3":"110.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"18.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"gdT-cell":"4.8","NK-cell":"15.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"41","RNA blood lineage specific nTPM":{"NK-cells":"15.9","T-cells":"4.8"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"4.0","skin cancer":"5.2"},"RNA tissue cell type enrichment":["Adipose visceral - Macrophages","Heart muscle - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"1.4"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024168"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":"Intracellular and membrane","Secretome function":"Receptor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA024168":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.72e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.44e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.96e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.66e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL13","Gene synonym":["ALRH","BHR1","IL-13","MGC116786","MGC116788","MGC116789","P600"],"Ensembl":"ENSG00000169194","Gene description":"Interleukin 13","Uniprot":["P35225"],"Chromosome":"5","Position":"132656263-132661110","Protein class":["Cancer-related genes","Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Cytokine"],"Disease involvement":["Cancer-related genes","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"45","RNA tissue specific nTPM":{"testis":"23.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"90.7","Late primary spermatocytes":"138.5","Late spermatids":"375.5","Mast cells":"87.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"375.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"45","RNA cell line specific nTPM":{"lymphoma":"4.8"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Interleukin","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":40000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL13RA2","Gene synonym":["CD213a2","CT19","IL-13R","IL13BP"],"Ensembl":"ENSG00000123496","Gene description":"Interleukin 13 receptor subunit alpha 2","Uniprot":["Q14627"],"Chromosome":"X","Position":"115003975-115019977","Protein class":["Cancer-related genes","CD markers","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"30.5","testis":"28.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"42.6","Early spermatids":"354.7","Epididymal basal cells":"100.1","Late primary spermatocytes":"184.4","Late spermatids":"69.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Basal cells":"100.1","Spermatogenic cell types":"354.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"14.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"34.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"hypothalamus":"24.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"77.2","Sarcoma":"84.5","skin cancer":"80.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Liver - Sinusoid Endothelial cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"7.0"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045831","HPA067363"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":12,"Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA045831":null,"HPA067363":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"}},{"Gene":"IL17D","Gene synonym":["FLJ30846","IL-17D","IL-27","IL27"],"Ensembl":"ENSG00000172458","Gene description":"Interleukin 17D","Uniprot":["Q8TAD2"],"Chromosome":"13","Position":"20702127-20723098","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Cytokine"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"148.9","skeletal muscle":"122.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"96.1","Bergmann glia":"139.0","Late spermatids":"53.1","M\u00fcller glia":"22.3","Myonuclei":"84.8","Oligodendrocyte progenitor cells":"30.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"139.0","Myocytes":"84.8","Spermatogenic cell types":"53.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"114.6","Bergmann glia":"142.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"73.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Fibroblasts","Minor Salivary Gland - Fibroblasts","Prostate - Fibroblasts","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"41178","Protein cell type specific Intensity":{"Smooth muscle cells":"4117787.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"2429874.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Interleukin","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":25000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"}},{"Gene":"IL17F","Gene synonym":["IL-17F","ML-1","ML1"],"Ensembl":"ENSG00000112116","Gene description":"Interleukin 17F","Uniprot":["Q96PD4"],"Chromosome":"6","Position":"52236681-52245689","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted secreted proteins"],"Biological process":["Adaptive immunity","Immunity","Inflammatory response","Innate immunity"],"Molecular function":["Cytokine"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"2.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Innate lymphoid cells":"4.1","T-cells":"8.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Innate lymphoid cells":"4.1","T-cells":"8.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"85","RNA cell line specific nTPM":{"lymphoma":"18.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":30000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL17RD","Gene synonym":["FLJ35755","IL-17RD","IL17RLM","SEF"],"Ensembl":"ENSG00000144730","Gene description":"Interleukin 17 receptor D","Uniprot":["Q8NFM7"],"Chromosome":"3","Position":"57089982-57170306","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["Disease variant","Hypogonadotropic hypogonadism","Kallmann syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"59.4","Choroid plexus epithelial cells":"107.7","Early spermatids":"32.2","Fibro-adipogenic progenitors":"57.2","Late primary spermatocytes":"31.7","Late spermatids":"42.4","Leydig cells":"41.0","Peritubular myoid cells":"45.1","Pituicytes\/FSCs":"33.8","Pituitary stem cells":"51.3","Podocytes":"79.2","Proximal tubule cells":"37.7","Salivary myoepithelial cells":"37.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"107.7","Fibro-adipogenic progenitors":"57.2","Renal nephron cells":"79.2","Secretory gland support":"59.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"85.5","endothelial cell":"76.8","fibroblast":"55.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"14.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA039577":null,"HPA043550":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.32e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.17e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.88e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"}},{"Gene":"IL20RB","Gene synonym":["DIRS1","FNDC6","IL-20R2","MGC34923"],"Ensembl":"ENSG00000174564","Gene description":"Interleukin 20 receptor subunit beta","Uniprot":["Q6UXL0"],"Chromosome":"3","Position":"136946230-137011085","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"cervix":"58.4","esophagus":"121.1","skin 1":"165.8","vagina":"74.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"102.4","Early spermatids":"60.7","Esophageal apical cells":"547.3","Esophageal basal cells":"174.1","Esophageal suprabasal cells":"273.2","Ocular epithelial cells":"87.7","Suprabasal keratinocytes":"142.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"547.3","Basal cells":"174.1","Suprabasal cells":"273.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"87.7","Head and Neck Squamous Cell Carcinoma (TCGA)":"80.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"56.6","head and neck cancer":"79.1"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":14,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA063914":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.16e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.26e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL21","Gene synonym":["IL-21","Za11"],"Ensembl":"ENSG00000138684","Gene description":"Interleukin 21","Uniprot":["Q9HBE4"],"Chromosome":"4","Position":"122610108-122621066","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Cytokine"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"lymphoid tissue":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"16.8","Late primary spermatocytes":"8.7","Late spermatids":"8.6","T-cells":"3.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"16.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"6043605.5","Glomeruli":"2655414.5","Neurons":"3568973.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"744803.7","pancreas":"1845287.9"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Interleukin","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":55700,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL21R","Gene synonym":["CD360"],"Ensembl":"ENSG00000103522","Gene description":"Interleukin 21 receptor","Uniprot":["Q9HBE5"],"Chromosome":"16","Position":"27402174-27452042","Protein class":["Cancer-related genes","CD markers","Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"7.1","lymphoid tissue":"22.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"25.3","cDC":"42.2","Innate lymphoid cells":"27.4","Kupffer cells":"22.5","NK-cells":"109.0","pDCs":"36.2","Plasma cells":"21.4","T-cells":"96.6","Thymic myoid cells":"65.3","Thymocytes":"20.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"42.2","NK-cells":"109.0","Stromal cells":"65.3","T-cells":"96.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"leukocyte":"66.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"53.9","Myeloma":"24.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042296":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"IL23A","Gene synonym":["IL-23","IL-23A","IL23P19","P19","SGRF"],"Ensembl":"ENSG00000110944","Gene description":"Interleukin 23 subunit alpha","Uniprot":["Q9NPF7"],"Chromosome":"12","Position":"56334174-56340410","Protein class":["FDA approved drug targets","Predicted secreted proteins"],"Biological process":["Antiviral defense","Immunity","Inflammatory response","Innate immunity","Tissue remodeling"],"Molecular function":["Cytokine"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"urinary bladder":"41.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"54.9","Early primary spermatocytes":"34.9","Endometrial secretory cells":"18.8","Epididymal basal cells":"54.8","Esophageal apical cells":"18.1","Innate lymphoid cells":"24.9","Late primary spermatocytes":"37.7","monocytes":"19.8","Plasma cells":"17.1","Urothelial cells":"22.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"54.8","dendritic cells":"54.9","Spermatogenic cell types":"37.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"MAIT T-cell":"14.2","memory B-cell":"19.0","memory CD4 T-cell":"25.8","memory CD8 T-cell":"12.5","naive B-cell":"21.6","naive CD4 T-cell":"28.2","naive CD8 T-cell":"17.7","T-reg":"15.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"B-cells":"21.6","T-cells":"28.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":11000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA001554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056427":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA068114":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.29e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL4I1","Gene synonym":["FIG1"],"Ensembl":"ENSG00000104951","Gene description":"Interleukin 4 induced 1","Uniprot":["Q96RQ9"],"Chromosome":"19","Position":"49889654-49929539","Protein class":["Enzymes","Metabolic proteins","Predicted secreted proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"lymphoid tissue":"17.1","testis":"27.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"244.4","Early spermatids":"67.2","Fallopian secretory cells":"139.8","Innate lymphoid cells":"379.1","Late primary spermatocytes":"124.3","Macrophages":"48.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"dendritic cells":"244.4","Innate lymphoid cells":"379.1","Secretory cells":"139.8","Spermatogenic cell types":"124.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"4.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"66.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"103.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"monocytes":"36.6","T-cells":"103.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"33.1","Myeloma":"18.6"},"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":3,"Subcellular main location":["Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA045598":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"}},{"Gene":"IL5RA","Gene synonym":["CD125","CDw125","IL5R"],"Ensembl":"ENSG00000091181","Gene description":"Interleukin 5 receptor subunit alpha","Uniprot":["Q01344"],"Chromosome":"3","Position":"3066324-3126613","Protein class":["CD markers","FDA approved drug targets","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"5.9","fallopian tube":"10.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"22.4","Corticotrophs":"23.0","Endometrial ciliated cells":"52.6","Ependymal cells":"90.1","Epididymal efferent duct ciliated cells":"44.9","Fallopian tube ciliated cells":"52.6","Late primary spermatocytes":"37.7","Mast cells":"71.9","Plasma cells":"39.7","Respiratory ciliated cells":"97.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"97.1","Mast cells":"71.9","Plasma cells":"39.7","Spermatogenic cell types":"37.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"101.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"3.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"190","RNA blood cell specific nTPM":{"basophil":"179.4","eosinophil":"356.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"253","RNA blood lineage specific nTPM":{"granulocytes":"356.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"2.7","Myeloma":"8.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"61000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"}},{"Gene":"IL7","Gene synonym":["IL-7"],"Ensembl":"ENSG00000104432","Gene description":"Interleukin 7","Uniprot":["P13232"],"Chromosome":"8","Position":"78675743-78805523","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Cytokine","Growth factor"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"158.3","Early spermatids":"156.7","Endometrial ciliated cells":"142.1","Epicardial cells":"259.3","Fibro-adipogenic progenitors":"191.2","Late primary spermatocytes":"135.6","Late spermatids":"246.7","Lymphatic endothelial cells":"202.9","Respiratory ciliated cells":"135.6","Retinal ganglion cells":"177.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"259.3","Endothelial cells":"202.9","Spermatogenic cell types":"246.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"9.8","naive B-cell":"8.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019590"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Interleukin","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":60700,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019590":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"}},{"Gene":"IMMP1L","Gene synonym":["FLJ25059","IMMP1"],"Ensembl":"ENSG00000148950","Gene description":"Inner mitochondrial membrane peptidase subunit 1","Uniprot":["Q96LU5"],"Chromosome":"11","Position":"31432401-31509645","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"593","Protein cell type specific Intensity":{"Distal tubules":"59347.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038372","HPA058308"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038372":null,"HPA058308":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.82e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"}},{"Gene":"INA","Gene synonym":["NEF5","NF-66"],"Ensembl":"ENSG00000148798","Gene description":"Internexin neuronal intermediate filament protein alpha","Uniprot":["Q16352"],"Chromosome":"10","Position":"103277138-103290346","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"116.7","pituitary gland":"38.6","retina":"90.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"47.9","Brain inhibitory neurons":"54.3","Cone photoreceptor cells":"51.8","Corticotrophs":"60.8","Early spermatids":"35.3","Gonadotrophs":"43.7","Lactotrophs":"36.8","Late primary spermatocytes":"46.5","Late spermatids":"37.7","Other brain neurons":"78.0","Pancreatic islet cells":"66.9","Retinal amacrine cells":"30.4","Retinal bipolar cells":"49.3","Retinal ganglion cells":"42.5","Retinal horizontal cells":"38.1","Rod photoreceptor cells":"39.1","Thyrotrophs":"25.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"78.0","Pancreatic islet cells":"66.9","Pituitary endocrine cells":"60.8","Spermatogenic cell types":"46.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"mammillary body":"160.5"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"22.9","Glioblastoma Multiforme (TCGA)":"7.8","Testicular Germ Cell Tumor (TCGA)":"29.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"58.9","Neuroblastoma":"66.0"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Pancreas - Beta cells","Pituitary gland - Lactotropes","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Thyroid gland - Parafollicular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"844569005.5","Microglia and Neuropil":"472938759.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1241034126.4"},"Antibody":["CAB002059","HPA007572","HPA008057"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Intermediate filaments","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"600000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":15,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB002059":null,"HPA007572":null,"HPA008057":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.37e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"}},{"Gene":"INAFM2","Gene synonym":["LINC00984","OGU1"],"Ensembl":"ENSG00000259330","Gene description":"InaF motif containing 2","Uniprot":["P0DMQ5"],"Chromosome":"15","Position":"40323692-40326715","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Platelets":"385.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Platelets":"385.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"2.7"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"1.1","granulocytes":"2.7","monocytes":"1.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"85000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.90e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.16e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"}},{"Gene":"ING1","Gene synonym":["p24ING1c","p33","p33ING1","p33ING1b","p47","p47ING1a"],"Ensembl":"ENSG00000153487","Gene description":"Inhibitor of growth family member 1","Uniprot":["Q9UK53"],"Chromosome":"13","Position":"110712736-110723339","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"267.1","Extravillous trophoblasts":"109.7","Late primary spermatocytes":"111.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"267.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"565577.9","T-cells":"468091.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB016136","CAB017773","HPA052591"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":28,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Endoplasmic reticulum","Cytosol"],"Antibody RRID":{"CAB016136":null,"CAB017773":null,"HPA052591":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"}},{"Gene":"ING2","Gene synonym":["ING1L","p33ING2"],"Ensembl":"ENSG00000168556","Gene description":"Inhibitor of growth family member 2","Uniprot":["Q9H160"],"Chromosome":"4","Position":"183505058-183512429","Protein class":["Predicted intracellular proteins"],"Biological process":["Growth regulation","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct ciliated cells":"162.4","Esophageal apical cells":"145.8","Extravillous trophoblasts":"128.3","Granulosa cells":"159.0","Late primary spermatocytes":"155.0","Ovarian stromal cells":"146.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":51,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA019486":null,"HPA021517":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.14e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"INHBC","Gene synonym":[],"Ensembl":"ENSG00000175189","Gene description":"Inhibin subunit beta C","Uniprot":["P55103"],"Chromosome":"12","Position":"57434784-57452062","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Growth factor","Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"138","RNA tissue specific nTPM":{"liver":"154.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Hepatocytes":"44.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Hepatocytes":"44.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"69","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"41.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"4.9"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"32000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA050755":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.67e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"INO80B","Gene synonym":["hIes2","HMGA1L4","HMGIYL4","IES2","PAP-1BP","PAPA-1","ZNHIT4"],"Ensembl":"ENSG00000115274","Gene description":"INO80 complex subunit B","Uniprot":["Q9C086"],"Chromosome":"2","Position":"74455087-74457944","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"4.2","Bergmann glia":"5.2","Brain excitatory neurons":"5.3","Brain inhibitory neurons":"4.6","Ependymal cells":"6.5","Megakaryocytes":"6.2","Microglia":"4.2","Oligodendrocyte progenitor cells":"3.6","Oligodendrocytes":"5.1","Other brain neurons":"7.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"6.5","Glial cells":"5.2","Megakaryocytes":"6.2","Neuronal cells":"7.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":83,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Nuclear bodies"],"Antibody RRID":{"HPA070644":null,"HPA078274":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":42,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Vesicles","Cytosol"],"Antibody RRID":{"HPA041731":null,"HPA049060":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.43e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"}},{"Gene":"INO80E","Gene synonym":["CCDC95","FLJ90652"],"Ensembl":"ENSG00000169592","Gene description":"INO80 complex subunit E","Uniprot":["Q8NBZ0"],"Chromosome":"16","Position":"29995715-30005793","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"295","Protein cell type specific Intensity":{"T-cells":"29504.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"301588.1","ovary":"253108.3"},"Antibody":["HPA043146"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":63,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli rim"],"Antibody RRID":{"HPA043146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"}},{"Gene":"INPP1","Gene synonym":[],"Ensembl":"ENSG00000151689","Gene description":"Inositol polyphosphate-1-phosphatase","Uniprot":["P49441"],"Chromosome":"2","Position":"190343570-190371665","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"898.1","Esophageal suprabasal cells":"352.2","Late spermatids":"1284.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1284.7","Suprabasal cells":"352.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"96.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"96.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Lung - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"15761843.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"61879971.5"},"Antibody":["HPA036698","HPA036699"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"49000","Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":5,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036698":null,"HPA036699":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-3"}},{"Gene":"INPP4B","Gene synonym":[],"Ensembl":"ENSG00000109452","Gene description":"Inositol polyphosphate-4-phosphatase type II B","Uniprot":["O15327"],"Chromosome":"4","Position":"142023160-142847432","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"881.1","Decidual stromal cells":"811.9","Endometrial stromal cells":"1103.0","Hematopoietic stem cells":"2670.7","Megakaryocyte progenitors":"1008.6","Melanocytes":"1699.8","Other brain neurons":"859.0","Pericytes":"1081.0","Urothelial cells":"816.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pigment cells":"1699.8","Stem cells":"2670.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"4297.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory CD4 T-cell":"30.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Liver - Hepatic stellate cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"1960453.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037681","HPA037682"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":1,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA037681":null,"HPA037682":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.09e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.37e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.59e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"}},{"Gene":"INPP5K","Gene synonym":["SKIP"],"Ensembl":"ENSG00000132376","Gene description":"Inositol polyphosphate-5-phosphatase K","Uniprot":["Q9BT40"],"Chromosome":"17","Position":"1494577-1516742","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Cataract","Congenital muscular dystrophy","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"137.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"612.1","Retinal pigment epithelial cells":"929.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Pigment cells":"929.3","Spermatogenic cell types":"612.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"50.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Minor Salivary Gland - Minor salivary glandular cells","Skin - Keratinocyte (granular)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"2216930.6","cerebral cortex":"766046.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 99: Retinal pigment epithelial cells - Retinol metabolism","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.72e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.19e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"}},{"Gene":"INSC","Gene synonym":[],"Ensembl":"ENSG00000188487","Gene description":"INSC spindle orientation adaptor protein","Uniprot":["Q1MX18"],"Chromosome":"11","Position":"15112424-15247208","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"parathyroid gland":"23.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"11.1","Foveolar cells":"18.9","Neutrophil progenitors":"9.8","Oligodendrocyte progenitor cells":"12.1","Oocytes":"13.8","Prostatic club cells":"29.9","Schwann cells":"117.2","Thyrotrophs":"13.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"29.9","Glial cells":"117.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"19.0","oligodendrocyte precursor cell":"14.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"5.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"3.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adrenal gland - Adrenal medulla cells","Colon - Enteric glia cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"449732.5"},"Antibody":["HPA039769"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039769":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"INSL6","Gene synonym":["RIF1"],"Ensembl":"ENSG00000120210","Gene description":"Insulin like 6","Uniprot":["Q9Y581"],"Chromosome":"9","Position":"5123880-5185647","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"retina":"6.1","testis":"14.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"71.6","Cardiomyocytes":"186.3","cDC":"43.9","Early primary spermatocytes":"50.0","Early spermatids":"142.0","Epicardial cells":"186.5","Late primary spermatocytes":"136.0","Myonuclei":"82.7","Undifferentiated spermatogonia":"64.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"186.5","Myocytes":"186.3","Spermatogenic cell types":"142.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"23","RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"20.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021364":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"INTS1","Gene synonym":["DKFZp586J0619","INT1","KIAA1440","NET28"],"Ensembl":"ENSG00000164880","Gene description":"Integrator complex subunit 1","Uniprot":["Q8N201"],"Chromosome":"7","Position":"1470277-1504389","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":64,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA021658":null,"HPA053009":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.48e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"}},{"Gene":"INTS6","Gene synonym":["DBI-1","DDX26","DDX26A","DICE1","HDB","INT6","Notchl2"],"Ensembl":"ENSG00000102786","Gene description":"Integrator complex subunit 6","Uniprot":["Q9UL03"],"Chromosome":"13","Position":"51354077-51454264","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal basal cells":"696.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":37,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Actin filaments"],"Antibody RRID":{"HPA001552":null,"HPA001846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.70e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"INTS7","Gene synonym":["C1orf73","DKFZP434B168","INT7"],"Ensembl":"ENSG00000143493","Gene description":"Integrator complex subunit 7","Uniprot":["Q9NVH2"],"Chromosome":"1","Position":"211940399-212035557","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Megakaryocyte-Erythroid progenitors":"108.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":15,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA072611":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.48e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"}},{"Gene":"IPO13","Gene synonym":["IMP13","KIAA0724","RANBP13"],"Ensembl":"ENSG00000117408","Gene description":"Importin 13","Uniprot":["O94829"],"Chromosome":"1","Position":"43946950-43968022","Protein class":["Essential proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"121.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"49.3","Late primary spermatocytes":"68.8","Late spermatids":"157.4","Oligodendrocytes":"83.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"83.1","Spermatogenic cell types":"157.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"104.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":48,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB070425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.81e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.82e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"}},{"Gene":"IPO4","Gene synonym":["FLJ23338","Imp4"],"Ensembl":"ENSG00000196497","Gene description":"Importin 4","Uniprot":["Q8TEX9"],"Chromosome":"14","Position":"24180219-24188869","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"55.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"2.3","Bergmann glia":"2.0","Brain excitatory neurons":"1.5","Brain inhibitory neurons":"1.5","Choroid plexus epithelial cells":"1.8","Distal convoluted tubule cells":"1.1","Ependymal cells":"3.2","Loop of henle epithelial cells":"1.2","Oligodendrocyte progenitor cells":"1.6","Oligodendrocytes":"1.8","Other brain neurons":"1.7","Proximal tubule cells":"1.5","Renal collecting duct principal cells":"1.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"3.2","Ductal cells":"1.5","Glial cells":"2.3","Neuronal cells":"1.7","Renal nephron cells":"1.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"86247085.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039043","HPA064572"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"38000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":47,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039043":null,"HPA064572":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.46e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.60e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"}},{"Gene":"IPO5","Gene synonym":["IMB3","KPNB3","MGC2068","PSE1","RANBP5"],"Ensembl":"ENSG00000065150","Gene description":"Importin 5","Uniprot":["O00410"],"Chromosome":"13","Position":"97953658-98024296","Protein class":["Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"196.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1447.9","Late primary spermatocytes":"586.0","Late spermatids":"3125.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3125.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB009110","HPA040983","HPA056548"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear membrane","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"770000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":114,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Golgi apparatus","Cytosol"],"Antibody RRID":{"CAB009110":null,"HPA040983":null,"HPA056548":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.06e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"}},{"Gene":"IPO8","Gene synonym":["IMP8","RANBP8"],"Ensembl":"ENSG00000133704","Gene description":"Importin 8","Uniprot":["O15397"],"Chromosome":"12","Position":"30628988-30695869","Protein class":["Disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Aortic aneurysm","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"22358279.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018439","HPA023765"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":77,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","End piece"],"Antibody RRID":{"HPA018439":null,"HPA023765":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.89e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"}},{"Gene":"IPP","Gene synonym":["KLHL27"],"Ensembl":"ENSG00000197429","Gene description":"Intracisternal A particle-promoted polypeptide","Uniprot":["Q9Y573"],"Chromosome":"1","Position":"45694324-45750653","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1219730.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA075545"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA075545":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.47e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.64e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"}},{"Gene":"IQANK1","Gene synonym":["FAM83H-AS1","onco-lncRNA-3"],"Ensembl":"ENSG00000203499","Gene description":"IQ motif and ankyrin repeat containing 1","Uniprot":["A8MXQ7"],"Chromosome":"8","Position":"143734139-143790645","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"39.7","skin 1":"27.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"7.2","Choroid plexus epithelial cells":"17.5","Distal convoluted tubule cells":"12.9","Ependymal cells":"59.8","Late primary spermatocytes":"7.5","Loop of henle epithelial cells":"17.2","Papillary tip epithelial cells":"39.9","Proximal tubule cells":"10.0","Renal collecting duct intercalated cells":"10.3","Renal collecting duct principal cells":"34.5","Renal connecting tubule cells":"17.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"59.8","Ductal cells":"34.5","Renal nephron cells":"39.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"69.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"}},{"Gene":"IQCA1L","Gene synonym":["IQCA1P1","TCAG_9762"],"Ensembl":"ENSG00000278685","Gene description":"IQ motif containing with AAA domain 1 like","Uniprot":["A6NCM1"],"Chromosome":"7","Position":"151190873-151205496","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"22","RNA tissue specific nTPM":{"testis":"4.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"22","RNA single cell type specific nCPM":{"Early spermatids":"30.5","Late primary spermatocytes":"49.9","Late spermatids":"38.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"28","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"49.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IQCC","Gene synonym":["FLJ10547"],"Ensembl":"ENSG00000160051","Gene description":"IQ motif containing C","Uniprot":["Q4KMZ1"],"Chromosome":"1","Position":"32205671-32208682","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"8.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"10.6","Breast lactating cells":"17.6","Early primary spermatocytes":"22.3","Epicardial cells":"22.7","Fallopian tube ciliated cells":"10.9","Late primary spermatocytes":"13.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"22.7","Secretory cells":"17.6","Spermatogenic cell types":"22.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA028602":null,"HPA028686":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-4"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"}},{"Gene":"IQCD","Gene synonym":["CFAP84","DRC10"],"Ensembl":"ENSG00000166578","Gene description":"IQ motif containing D","Uniprot":["Q96DY2"],"Chromosome":"12","Position":"113195441-113221094","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"20.8","fallopian tube":"20.7","testis":"42.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"140.2","Endometrial ciliated cells":"94.5","Ependymal cells":"62.9","Epididymal efferent duct ciliated cells":"102.8","Esophageal apical cells":"88.5","Fallopian tube ciliated cells":"172.3","Late primary spermatocytes":"240.9","Late spermatids":"134.6","Respiratory ciliated cells":"179.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"88.5","Ciliated cells":"179.1","Spermatogenic cell types":"240.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"30.5","ependymal cell":"71.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"15.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.9","plasmacytoid DC":"1.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"1.4","granulocytes":"1.9","monocytes":"1.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA046810":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.76e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"}},{"Gene":"IQCE","Gene synonym":["KIAA1023"],"Ensembl":"ENSG00000106012","Gene description":"IQ motif containing E","Uniprot":["Q6IPM2"],"Chromosome":"7","Position":"2558972-2614733","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"561.7","Late primary spermatocytes":"185.1","Late spermatids":"557.6","Respiratory ciliated cells":"137.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"561.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"3.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"2.4","granulocytes":"3.8","monocytes":"1.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"4737329.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"6382","Protein tissue specific Intensity":{"fallopian tube":"638208.7"},"Antibody":["HPA019515"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane","Plasma membrane","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":9,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Nuclear membrane","Primary cilium"],"Antibody RRID":{"HPA019515":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"}},{"Gene":"IQCG","Gene synonym":["CFAP122","DKFZp434B227","DRC9"],"Ensembl":"ENSG00000114473","Gene description":"IQ motif containing G","Uniprot":["Q9H095"],"Chromosome":"3","Position":"197889077-197960142","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Calmodulin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"51.6","fallopian tube":"49.6","testis":"41.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"300.1","Endometrial ciliated cells":"300.1","Ependymal cells":"327.4","Epididymal efferent duct ciliated cells":"327.8","Fallopian tube ciliated cells":"352.3","Granulosa cells":"454.2","Late primary spermatocytes":"255.2","Late spermatids":"666.1","Mesothelial cells":"236.0","Respiratory ciliated cells":"426.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"426.4","Reproductive supporting cells":"454.2","Spermatogenic cell types":"666.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"356.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"119585","Protein cell type specific Intensity":{"Fallopian tube cells":"11958510.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"25835","Protein tissue specific Intensity":{"fallopian tube":"2583477.2"},"Antibody":["HPA042787","HPA051981"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Actin filaments","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":null,"Subcellular main location":["Actin filaments","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042787":null,"HPA051981":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles","Mid piece"],"Antibody RRID":{"HPA040845":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.46e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"}},{"Gene":"IQCK","Gene synonym":["FLJ36575","MGC35048"],"Ensembl":"ENSG00000174628","Gene description":"IQ motif containing K","Uniprot":["Q8N0W5"],"Chromosome":"16","Position":"19716456-19858467","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"227.3","Bergmann glia":"230.0","Cone photoreceptor cells":"227.7","Ependymal cells":"353.7","Fallopian tube ciliated cells":"230.7","Respiratory ciliated cells":"333.1","Rod photoreceptor cells":"339.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"353.7","Glial cells":"230.0","Neuronal cells":"339.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"389.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA026792":null,"HPA048786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"}},{"Gene":"IQCM","Gene synonym":[],"Ensembl":"ENSG00000234828","Gene description":"IQ motif containing M","Uniprot":["A0A1B0GVH7"],"Chromosome":"4","Position":"149351709-149896233","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"4.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"80.2","Early spermatids":"180.4","Enteric stem cells":"29.7","Enteric transient amplifying cells":"44.0","Goblet cells":"93.4","Late primary spermatocytes":"231.1","Late spermatids":"26.9","Tuft cells":"92.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"80.2","Goblet cells":"93.4","Secretory gland support":"92.2","Spermatogenic cell types":"231.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"12.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IQCN","Gene synonym":["KIAA1683"],"Ensembl":"ENSG00000130518","Gene description":"IQ motif containing N","Uniprot":["Q9H0B3"],"Chromosome":"19","Position":"18257098-18274500","Protein class":["Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"30.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"113.7","Early spermatids":"122.1","Late spermatids":"141.7","Medullary thymic epithelial cells":"127.2","Transitional alveolar cells":"115.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"19598","Protein tissue specific Intensity":{"fallopian tube":"1959777.4"},"Antibody":["HPA042409"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Acrosome","Equatorial segment"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":10,"Subcellular main location":["Acrosome","Equatorial segment"],"Subcellular additional location":null,"Antibody RRID":{"HPA042409":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"}},{"Gene":"IQGAP2","Gene synonym":[],"Ensembl":"ENSG00000145703","Gene description":"IQ motif containing GTPase activating protein 2","Uniprot":["Q13576"],"Chromosome":"5","Position":"76403285-76708132","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Calmodulin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"105.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1327.8","Hematopoietic stem cells":"1342.6","Neutrophil progenitors":"821.6","Neutrophils":"1152.9","NK-cells":"960.4","Podocytes":"1896.0","Salivary ionocytes":"816.4","Thymocytes":"1528.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"1896.0","T-cells":"1528.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"335.0","fibroblast":"321.8","leukocyte":"868.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"21.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Liver - Hepatocytes","Pituitary gland - Undifferentiated cells (Pituitary gland)","Prostate - Prostate glandular cells","Skeletal muscle - Macrophages","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"hippocampal formation":"30.5"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"569857356.0","Hepatocytes":"531931549.2","Large ducts":"789055579.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"238514496.6"},"Antibody":["CAB004241","HPA037403","HPA037404"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1700000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":19,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB004241":null,"HPA037403":null,"HPA037404":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.85e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.50e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.89e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"}},{"Gene":"IQUB","Gene synonym":["FLJ35834"],"Ensembl":"ENSG00000164675","Gene description":"IQ motif and ubiquitin domain containing","Uniprot":["Q8NA54"],"Chromosome":"7","Position":"123452193-123535077","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"31.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"92.4","Early spermatids":"255.6","Endometrial ciliated cells":"142.3","Ependymal cells":"181.7","Fallopian tube ciliated cells":"151.8","Late primary spermatocytes":"393.6","Late spermatids":"258.8","Oocytes":"119.7","Renal collecting duct principal cells":"79.9","Renal connecting tubule cells":"98.1","Respiratory ciliated cells":"222.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"222.0","Ductal cells":"98.1","Oocytes":"119.7","Spermatogenic cell types":"393.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"93.1","ependymal cell":"213.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"2.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":58,"Subcellular main location":["Nuclear speckles","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA049626":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"}},{"Gene":"IRAK1BP1","Gene synonym":["AIP70","SIMPL"],"Ensembl":"ENSG00000146243","Gene description":"Interleukin 1 receptor associated kinase 1 binding protein 1","Uniprot":["Q5VVH5"],"Chromosome":"6","Position":"78867551-78946440","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"19975","Protein cell type specific Intensity":{"Fallopian tube cells":"1997461.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"296","Protein tissue specific Intensity":{"fallopian tube":"29579.9"},"Antibody":["HPA035742","HPA035743"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":8,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035742":null,"HPA035743":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.01e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"}},{"Gene":"ISCA1","Gene synonym":["HBLD2","hIscA","ISA1","MGC4276"],"Ensembl":"ENSG00000135070","Gene description":"Iron-sulfur cluster assembly 1","Uniprot":["Q9BUE6"],"Chromosome":"9","Position":"86264546-86283102","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"896.4","Late primary spermatocytes":"321.5","Late spermatids":"770.4","Megakaryocytes":"408.0","Platelets":"307.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"408.0","Spermatogenic cell types":"896.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042789":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.73e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.15e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.99e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.27e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"}},{"Gene":"ISLR2","Gene synonym":["KIAA1465"],"Ensembl":"ENSG00000167178","Gene description":"Immunoglobulin superfamily containing leucine rich repeat 2","Uniprot":["Q6UXK2"],"Chromosome":"15","Position":"74100311-74138540","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"15.5","heart muscle":"4.4","testis":"12.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"121.7","Late spermatids":"180.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"180.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"35.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"6.8"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"87.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Neuroblastoma":"44.6","thyroid cancer":"16.4"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"12621","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1201204.4","Microglia and Neuropil":"1865077.1","Neurons":"720158.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"88452","Protein tissue specific Intensity":{"cerebral cortex":"8845161.2"},"Antibody":["HPA012930","HPA067333"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA012930":null,"HPA067333":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"}},{"Gene":"ISOC2","Gene synonym":["FLJ23469"],"Ensembl":"ENSG00000063241","Gene description":"Isochorismatase domain containing 2","Uniprot":["Q96AB3"],"Chromosome":"19","Position":"55452985-55462343","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"262.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"231.4","Esophageal basal cells":"200.2","Hepatocytes":"322.3","Late primary spermatocytes":"316.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"322.3","Spermatogenic cell types":"316.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA043142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"}},{"Gene":"ITCH","Gene synonym":["AIP4"],"Ensembl":"ENSG00000078747","Gene description":"Itchy E3 ubiquitin protein ligase","Uniprot":["Q96J02"],"Chromosome":"20","Position":"34363235-34511773","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Antiviral defense","Apoptosis","Host-virus interaction","Immunity","Innate immunity","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"103.4","Bergmann glia":"133.0","Brain excitatory neurons":"107.4","Brain inhibitory neurons":"100.6","Choroid plexus epithelial cells":"286.1","Distal convoluted tubule cells":"226.0","Ependymal cells":"107.5","Loop of henle epithelial cells":"180.7","Microglia":"187.9","Oligodendrocyte progenitor cells":"123.6","Oligodendrocytes":"360.6","Papillary tip epithelial cells":"207.9","Podocytes":"211.1","Proximal tubule cells":"258.0","Renal collecting duct intercalated cells":"194.8","Renal collecting duct principal cells":"188.9","Renal connecting tubule cells":"219.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"286.1","Ductal cells":"219.6","Glial cells":"360.6","Neuronal cells":"107.4","Renal nephron cells":"258.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA021126","HPA049032","CAB072824","CAB072825"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":141,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB072824":null,"CAB072825":null,"HPA021126":null,"HPA049032":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.00e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.48e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.26e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.27e-7"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"}},{"Gene":"ITGAE","Gene synonym":["CD103","HUMINAE"],"Ensembl":"ENSG00000083457","Gene description":"Integrin subunit alpha E","Uniprot":["P38570"],"Chromosome":"17","Position":"3714628-3801188","Protein class":["CD markers","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Integrin","Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"6.1","intestine":"5.5","lung":"6.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"152.1","Esophageal suprabasal cells":"158.5","Late primary spermatocytes":"210.1","NK-cells":"152.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"73.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory CD8 T-cell":"3.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"T-cells":"3.7"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"Leukemia":"1.7","lymphoma":"2.5"},"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"137","Protein tissue specific Intensity":{"intestine":"13703.0"},"Antibody":["HPA036313","HPA052147"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"94000","Blood expression cluster":"Cluster 27: T-cells - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036313":null,"HPA052147":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":45,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA028463":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.51e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"}},{"Gene":"ITK","Gene synonym":["EMT","LYK","PSCTK2"],"Ensembl":"ENSG00000113263","Gene description":"IL2 inducible T cell kinase","Uniprot":["Q08881"],"Chromosome":"5","Position":"157142933-157255185","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":["Kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"lymphoid tissue":"53.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"74.1","Innate lymphoid cells":"135.9","Mast cells":"125.3","NK-cells":"295.4","T-cells":"564.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Innate lymphoid cells":"135.9","Mast cells":"125.3","NK-cells":"295.4","T-cells":"564.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"55","RNA single nuclei brain specific nCPM":{"leukocyte":"398.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"22","RNA blood cell specific nTPM":{"gdT-cell":"39.0","MAIT T-cell":"26.3","memory CD4 T-cell":"55.6","memory CD8 T-cell":"53.5","naive CD4 T-cell":"77.6","naive CD8 T-cell":"63.5","NK-cell":"28.7","T-reg":"70.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"22","RNA blood lineage specific nTPM":{"NK-cells":"28.7","T-cells":"77.6"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"23","RNA cell line specific nTPM":{"Leukemia":"7.3","lymphoma":"4.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 39: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":26,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA060674":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.31e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.83e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ITPKA","Gene synonym":["IP3-3KA","IP3KA"],"Ensembl":"ENSG00000137825","Gene description":"Inositol-trisphosphate 3-kinase A","Uniprot":["P23677"],"Chromosome":"15","Position":"41493393-41503551","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Calmodulin-binding","Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"57.3","intestine":"17.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"300.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"300.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"miscellaneous":"32.8","upper-layer intratelencephalic":"53.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"MAIT T-cell":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"T-cells":"1.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040454":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.71e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA024103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038104":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IZUMO3","Gene synonym":["bA20A20.1","C9orf134"],"Ensembl":"ENSG00000205442","Gene description":"IZUMO family member 3","Uniprot":["Q5VZ72"],"Chromosome":"9","Position":"24542952-24545946","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"130","RNA tissue specific nTPM":{"testis":"12.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"69","RNA single cell type specific nCPM":{"Early spermatids":"211.8","Late primary spermatocytes":"189.0","Late spermatids":"142.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"124","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"211.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"lower rhombic lip":"8.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"1.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"17","RNA cell line specific nTPM":{"Sarcoma":"5.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Acrosome","Equatorial segment"],"Subcellular additional location":null,"Antibody RRID":{"HPA045722":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IZUMO4","Gene synonym":["C19orf36"],"Ensembl":"ENSG00000099840","Gene description":"IZUMO family member 4","Uniprot":["Q1ZYL8"],"Chromosome":"19","Position":"2096429-2099593","Protein class":["Predicted intracellular proteins","Predicted secreted proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"testis":"430.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"21","RNA single cell type specific nCPM":{"Early spermatids":"1650.2","Late primary spermatocytes":"2332.3","Late spermatids":"4016.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"71","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4016.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"34.8","Bergmann glia":"55.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"lymphoma":"10.8","Myeloma":"6.9","Rhabdoid":"2.9"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Equatorial segment","Calyx","Connecting piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA048496":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"}},{"Gene":"JAKMIP2","Gene synonym":["JAMIP2","KIAA0555"],"Ensembl":"ENSG00000176049","Gene description":"Janus kinase and microtubule interacting protein 2","Uniprot":["Q96AA8"],"Chromosome":"5","Position":"147585438-147782775","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"18.2","pituitary gland":"7.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"276.6","Astrocytes":"250.4","Bergmann glia":"199.8","Brain excitatory neurons":"350.7","Brain inhibitory neurons":"248.1","Corticotrophs":"281.0","Ependymal cells":"328.7","Gonadotrophs":"458.3","Lactotrophs":"218.6","Oligodendrocyte progenitor cells":"195.6","Oligodendrocytes":"250.7","Other brain neurons":"235.6","Retinal amacrine cells":"195.7","Retinal ganglion cells":"367.0","Retinal horizontal cells":"394.7","Somatotrophs":"239.7","Thyrotrophs":"399.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"276.6","Ciliated cells":"328.7","Glial cells":"250.7","Neuronal cells":"394.7","Pituitary endocrine cells":"458.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"17.7","Lung Squamous Cell Carcinoma (TCGA)":"4.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"gdT-cell":"7.3","MAIT T-cell":"5.3","memory CD4 T-cell":"2.8","memory CD8 T-cell":"5.5","naive CD8 T-cell":"4.6","NK-cell":"7.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"NK-cells":"7.0","T-cells":"7.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"24.7"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":13,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA046929":null,"HPA065023":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.67e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"JHY","Gene synonym":["C11orf63","FLJ23554"],"Ensembl":"ENSG00000109944","Gene description":"Junctional cadherin complex regulator","Uniprot":["Q6NUN7"],"Chromosome":"11","Position":"122882683-122963862","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"16.1","testis":"33.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"215.1","Endometrial ciliated cells":"92.7","Ependymal cells":"163.7","Epididymal efferent duct ciliated cells":"86.9","Fallopian tube ciliated cells":"110.1","Late primary spermatocytes":"132.3","Late spermatids":"78.1","Podocytes":"76.9","Respiratory ciliated cells":"134.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"215.1","Spermatogenic cell types":"132.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"161.5","ependymal cell":"180.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA039612":null,"HPA040344":null,"HPA077658":null,"HPA077748":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.10e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.68e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.33e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"}},{"Gene":"JKAMP","Gene synonym":["C14orf100","CDA06","HSPC213","HSPC327","JAMP"],"Ensembl":"ENSG00000050130","Gene description":"JNK1\/MAPK8 associated membrane protein","Uniprot":["Q9P055"],"Chromosome":"14","Position":"59484443-59505410","Protein class":["Cancer-related genes","Predicted membrane proteins"],"Biological process":["Unfolded protein response"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"169.7","Late primary spermatocytes":"206.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"206.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031172","HPA071650"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA031172":null,"HPA071650":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.71e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.32e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"}},{"Gene":"JMJD4","Gene synonym":["FLJ12517"],"Ensembl":"ENSG00000081692","Gene description":"Jumonji domain containing 4","Uniprot":["Q9H9V9"],"Chromosome":"1","Position":"227730425-227735411","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"53.3","Cardiomyocytes":"76.1","Early spermatids":"68.1","Epicardial cells":"84.1","Late primary spermatocytes":"91.0","Late spermatids":"331.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"84.1","Spermatogenic cell types":"331.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"82373.6","Granulosa cells":"74727.3","Oocytes":"69060.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027260","HPA052861"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA027260":null,"HPA052861":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"}},{"Gene":"JPT1","Gene synonym":["ARM2","HN1","HN1A"],"Ensembl":"ENSG00000189159","Gene description":"Jupiter microtubule associated homolog 1","Uniprot":["Q9UK76"],"Chromosome":"17","Position":"75135248-75168281","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"394.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1314.5","Esophageal apical cells":"1438.3","Esophageal suprabasal cells":"1069.5","Extravillous trophoblasts":"2151.7","Gastric progenitor cells":"975.4","Late primary spermatocytes":"2043.7","Late spermatids":"1773.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1438.3","Spermatogenic cell types":"2043.7","Suprabasal cells":"1069.5","Trophoblast cells":"2151.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"773.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2209597.3","Granulosa cells":"2286149.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"38546537.9"},"Antibody":["HPA011097","HPA059729","HPA076731"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Microtubules","Cytokinetic bridge","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"41000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":9,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Microtubules","Cytokinetic bridge"],"Antibody RRID":{"HPA011097":null,"HPA059729":null,"HPA076731":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.89e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.16e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.88e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.87e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"}},{"Gene":"KANSL1L","Gene synonym":["C2orf67","FLJ23861","FLJ32349","KIAA1267L","MSL1v2"],"Ensembl":"ENSG00000144445","Gene description":"KAT8 regulatory NSL complex subunit 1 like","Uniprot":["A0AUZ9"],"Chromosome":"2","Position":"210021421-210171409","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"parathyroid gland":"187.0"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043102","HPA046790"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043102":null,"HPA046790":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.00e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"}},{"Gene":"KANSL3","Gene synonym":["FLJ10081","KIAA1310","NSL3","Rcd1"],"Ensembl":"ENSG00000114982","Gene description":"KAT8 regulatory NSL complex subunit 3","Uniprot":["Q9P2N6"],"Chromosome":"2","Position":"96593170-96642787","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"182.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"182.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA035017":null,"HPA035018":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.99e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.94e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"}},{"Gene":"KARS1","Gene synonym":["DFNB89","KARS","KARS2"],"Ensembl":"ENSG00000065427","Gene description":"Lysyl-tRNA synthetase 1","Uniprot":["Q15046"],"Chromosome":"16","Position":"75627474-75648643","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase","Transferase"],"Disease involvement":["Charcot-Marie-Tooth disease","Deafness","Disease variant","Intellectual disability","Neurodegeneration","Neuropathy","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"269.0","Late primary spermatocytes":"281.3","Late spermatids":"394.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"394.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041345","HPA041550"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"74000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":46,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA041345":null,"HPA041550":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.85e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.35e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":98,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019937":null,"HPA019940":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KAT5","Gene synonym":["cPLA2","ESA1","HTATIP","HTATIP1","PLIP","TIP60","ZC2HC5"],"Ensembl":"ENSG00000172977","Gene description":"Lysine acetyltransferase 5","Uniprot":["Q92993"],"Chromosome":"11","Position":"65711996-65719604","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transcription factors"],"Biological process":["DNA damage","DNA repair","Growth regulation","Host-virus interaction","Immunity","Innate immunity","Transcription","Transcription regulation"],"Molecular function":["Activator","Acyltransferase","Chromatin regulator","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Syncytiotrophoblasts":"152.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"152.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":288,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA016953":null,"HPA074328":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.81e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.57e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"KAT7","Gene synonym":["HBO1","HBOA","MYST2","ZC2HC7"],"Ensembl":"ENSG00000136504","Gene description":"Lysine acetyltransferase 7","Uniprot":["O95251"],"Chromosome":"17","Position":"49788624-49835026","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["DNA damage","DNA repair","DNA replication","Transcription","Transcription regulation"],"Molecular function":["Acyltransferase","Chromatin regulator","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"5095459.5","Pancreas epithelial cells":"5083154.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2017439.6"},"Antibody":["HPA044470","HPA071116"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":61,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA044470":null,"HPA071116":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.36e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.01e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":18,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA036207":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.88e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"}},{"Gene":"KATNAL1","Gene synonym":["MGC2599"],"Ensembl":"ENSG00000102781","Gene description":"Katanin catalytic subunit A1 like 1","Uniprot":["Q9BW62"],"Chromosome":"13","Position":"30202630-30307551","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"220.3","Ependymal cells":"152.5","Late primary spermatocytes":"155.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"220.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":21,"Subcellular main location":["Centrosome","Cytosol"],"Subcellular additional location":["Mitotic spindle","Mitochondria"],"Antibody RRID":{"HPA039759":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.64e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.50e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"KATNAL2","Gene synonym":["DKFZP667C165","MGC33211"],"Ensembl":"ENSG00000167216","Gene description":"Katanin catalytic subunit A1 like 2","Uniprot":["Q8IYT4"],"Chromosome":"18","Position":"46917492-47103478","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"11.7","testis":"12.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"129.0","Choroid plexus epithelial cells":"298.5","Distal convoluted tubule cells":"114.0","Ependymal cells":"254.7","Late primary spermatocytes":"163.7","Loop of henle epithelial cells":"114.8","Renal connecting tubule cells":"133.4","Respiratory ciliated cells":"126.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"298.5","Spermatogenic cell types":"163.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"271.6","ependymal cell":"257.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"27.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"17713018.8","Hepatocytes":"20970697.3","Large ducts":"20005245.0","Pancreas epithelial cells":"41112325.8","T-cells":"15799162.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"16071293.9"},"Antibody":["HPA040712","HPA042029"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Intermediate filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":3,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA040712":null,"HPA042029":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.95e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.45e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.95e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"}},{"Gene":"KATNB1","Gene synonym":[],"Ensembl":"ENSG00000140854","Gene description":"Katanin regulatory subunit B1","Uniprot":["Q9BVA0"],"Chromosome":"16","Position":"57735739-57757244","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":["Disease variant","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"105.9","Fallopian tube ciliated cells":"47.4","Late primary spermatocytes":"135.2","Respiratory ciliated cells":"54.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"135.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2233955.4","Microglia and Neuropil":"2797558.7","Neurons":"3032581.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"804254.1","intestine":"2443296.7"},"Antibody":["HPA041165","HPA041839"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Microtubules","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":25,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane","Microtubules"],"Antibody RRID":{"HPA041165":null,"HPA041839":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.88e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"}},{"Gene":"KATNIP","Gene synonym":["JBTS26","KIAA0556"],"Ensembl":"ENSG00000047578","Gene description":"Katanin interacting protein","Uniprot":["O60303"],"Chromosome":"16","Position":"27550133-27780344","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"260.1","Cone photoreceptor cells":"225.6","Endometrial ciliated cells":"224.7","Fallopian tube ciliated cells":"217.5","Respiratory ciliated cells":"336.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"336.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"14.3","eosinophil":"3.6","neutrophil":"10.0","NK-cell":"5.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"14.3","NK-cells":"5.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2233714.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"21796","Protein tissue specific Intensity":{"fallopian tube":"2179575.3"},"Antibody":["HPA035089","HPA035090"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium","Centriolar satellite","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":8,"Subcellular main location":["Nucleoplasm","Basal body"],"Subcellular additional location":["Primary cilium","Centriolar satellite"],"Antibody RRID":{"HPA035089":null,"HPA035090":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.69e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-3"}},{"Gene":"KBTBD3","Gene synonym":["BKLHD3"],"Ensembl":"ENSG00000182359","Gene description":"Kelch repeat and BTB domain containing 3","Uniprot":["Q8NAB2"],"Chromosome":"11","Position":"106051098-106077459","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"115.2","Late primary spermatocytes":"90.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"115.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"7421","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1071573.3","Microglia and Neuropil":"667669.0","Neurons":"487173.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"14323","Protein tissue specific Intensity":{"cerebral cortex":"1432315.5"},"Antibody":["HPA047385"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047385":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.65e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.78e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"}},{"Gene":"KCMF1","Gene synonym":["DEBT91","DKFZP434L1021","PCMF","ZZZ1"],"Ensembl":"ENSG00000176407","Gene description":"Potassium channel modulatory factor 1","Uniprot":["Q9P0J7"],"Chromosome":"2","Position":"84971093-85059472","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"425.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"3162128.8"},"Antibody":["HPA030383","HPA030384"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":36,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA030383":null,"HPA030384":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.24e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.21e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"}},{"Gene":"KCNA10","Gene synonym":["Kv1.8"],"Ensembl":"ENSG00000143105","Gene description":"Potassium voltage-gated channel subfamily A member 10","Uniprot":["Q16322"],"Chromosome":"1","Position":"110517217-110519175","Protein class":["FDA approved drug targets","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":null,"Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNB2","Gene synonym":["Kv2.2"],"Ensembl":"ENSG00000182674","Gene description":"Potassium voltage-gated channel subfamily B member 2","Uniprot":["Q92953"],"Chromosome":"8","Position":"72537225-72938349","Protein class":["FDA approved drug targets","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.0","lymphoid tissue":"2.2","retina":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"338.9","Cone photoreceptor cells":"5059.4","Corticotrophs":"1310.8","Gonadotrophs":"593.3","Neuroendocrine cells":"864.1","Other brain neurons":"383.4","Pancreatic islet cells":"560.3","Pituitary stem cells":"793.2","Retinal amacrine cells":"469.4","Somatotrophs":"481.7","Thyrotrophs":"359.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enteroendocrine cells":"864.1","Neuronal cells":"5059.4","Pituitary endocrine cells":"1310.8","Stem cells":"793.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"miscellaneous":"1482.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.8"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Pancreas - Beta cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"150","Protein tissue specific Intensity":{"cerebral cortex":"15022.4"},"Antibody":["HPA065970"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Plasma membrane","Midbody"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoli","Midbody"],"Antibody RRID":{"HPA065970":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNC1","Gene synonym":["Kv3.1"],"Ensembl":"ENSG00000129159","Gene description":"Potassium voltage-gated channel subfamily C member 1","Uniprot":["P48547"],"Chromosome":"11","Position":"17734774-17856804","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"brain":"98.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"118.4","Brain inhibitory neurons":"85.5","Cardiomyocytes":"48.7","Epicardial cells":"81.9","Other brain neurons":"56.3","Retinal amacrine cells":"310.8","Retinal bipolar cells":"69.1","Retinal ganglion cells":"108.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"81.9","Neuronal cells":"310.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"3.3","neutrophil":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"3.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"7.7"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":2,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA047634":null,"HPA048249":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNF1","Gene synonym":["IK8","KCNF","kH1","Kv5.1"],"Ensembl":"ENSG00000162975","Gene description":"Potassium voltage-gated channel modifier subfamily F member 1","Uniprot":["Q9H3M0"],"Chromosome":"2","Position":"10911934-10914225","Protein class":["Plasma proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"brain":"45.3","choroid plexus":"23.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"7.8","Brain inhibitory neurons":"10.7","Choroid plexus epithelial cells":"17.0","Extravillous trophoblasts":"22.9","Fallopian secretory cells":"5.1","Late spermatids":"5.8","Oligodendrocyte progenitor cells":"31.4","Other brain neurons":"7.7","Schwann cells":"4.9","Syncytiotrophoblasts":"10.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"17.0","Glial cells":"31.4","Neuronal cells":"10.7","Trophoblast cells":"22.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"46.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"11.5","lung cancer":"9.0"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":9,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Vesicles","Primary cilium transition zone"],"Antibody RRID":{"HPA014738":null,"HPA062278":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNH1","Gene synonym":["eag","eag1","h-eag","hEAG","Kv10.1"],"Ensembl":"ENSG00000143473","Gene description":"Potassium voltage-gated channel subfamily H member 1","Uniprot":["O95259"],"Chromosome":"1","Position":"210676823-211134165","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Calmodulin-binding","Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"brain":"15.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Respiratory ionocytes":"609.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ionocytes":"609.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"338.3","upper-layer intratelencephalic":"317.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"2.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Adrenocortical cancer":"20.7"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":5,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA014551":null,"HPA019445":null,"HPA076421":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.96e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNH5","Gene synonym":["eag2","H-EAG2","hEAG2","Kv10.2"],"Ensembl":"ENSG00000140015","Gene description":"Potassium voltage-gated channel subfamily H member 5","Uniprot":["Q8NCM2"],"Chromosome":"14","Position":"62699464-63102037","Protein class":["Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Calmodulin-binding","Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.1","retina":"4.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"127.6","Brain excitatory neurons":"89.8","Brain inhibitory neurons":"87.8","Choroid plexus epithelial cells":"357.0","Corticotrophs":"416.1","Mesothelial cells":"111.8","Oligodendrocyte progenitor cells":"119.3","Other brain neurons":"90.6","Pituitary stem cells":"95.2","Retinal amacrine cells":"498.5","Retinal bipolar cells":"417.9","Retinal pigment epithelial cells":"439.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"357.0","Neuronal cells":"498.5","Pigment cells":"439.1","Pituitary endocrine cells":"416.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"thalamic excitatory":"525.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"1.4","cervical cancer":"1.2"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA030487":null,"HPA072351":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNH7","Gene synonym":["erg3","HERG3","Kv11.3"],"Ensembl":"ENSG00000184611","Gene description":"Potassium voltage-gated channel subfamily H member 7","Uniprot":["Q9NS40"],"Chromosome":"2","Position":"162371407-162838767","Protein class":["FDA approved drug targets","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.4","retina":"1.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"529.4","Brain inhibitory neurons":"325.6","Corticotrophs":"928.1","Distal convoluted tubule cells":"184.3","Late spermatids":"359.2","Other brain neurons":"518.4","Retinal bipolar cells":"457.3","Retinal ganglion cells":"154.5","Retinal horizontal cells":"969.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"969.6","Pituitary endocrine cells":"928.1","Spermatogenic cell types":"359.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018039":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNJ15","Gene synonym":["IRKK","Kir1.3","Kir4.2"],"Ensembl":"ENSG00000157551","Gene description":"Potassium inwardly rectifying channel subfamily J member 15","Uniprot":["Q99712"],"Chromosome":"21","Position":"38155549-38307357","Protein class":["FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Voltage-gated channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"225.4","thyroid gland":"121.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"2664.8","Proximal tubule cells":"1013.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"2664.8","Renal nephron cells":"1013.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"1.5","fibroblast":"1.2","hippocampal CA1-3":"1.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"102.3","Thyroid Carcinoma (TCGA)":"124.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"21","RNA blood cell specific nTPM":{"neutrophil":"398.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"21","RNA blood lineage specific nTPM":{"granulocytes":"398.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"22.2","head and neck cancer":"20.7"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":3,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA016702":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.35e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.68e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"}},{"Gene":"KCNMA1","Gene synonym":["KCa1.1","mSLO1","SLO"],"Ensembl":"ENSG00000156113","Gene description":"Potassium calcium-activated channel subfamily M alpha 1","Uniprot":["Q12791"],"Chromosome":"10","Position":"76869601-77638369","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"1320.9","Kupffer cells":"870.1","Lacrimal acinar cells":"1058.0","Myonuclei":"1079.6","Neutrophils":"829.9","Oligodendrocyte progenitor cells":"1022.8","Retinal bipolar cells":"1789.6","Salivary acinar cells":"1516.9","Salivary ionocytes":"1694.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"1516.9","Ciliated cells":"1320.9","Ionocytes":"1694.7","Neuronal cells":"1789.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"2.5","non-classical monocyte":"1.7"},"RNA blood lineage specificity":"Lineage enhanced","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":{"monocytes":"2.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054648":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.61e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"}},{"Gene":"KCNQ5","Gene synonym":["Kv7.5"],"Ensembl":"ENSG00000185760","Gene description":"Potassium voltage-gated channel subfamily Q member 5","Uniprot":["Q9NR82"],"Chromosome":"6","Position":"72621792-73198853","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"4.0","brain":"12.5","skeletal muscle":"15.2","thyroid gland":"4.1","tongue":"11.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"531.8","B-cells":"506.7","Brain excitatory neurons":"956.2","Brain inhibitory neurons":"1755.9","Hematopoietic stem cells":"576.4","Innate lymphoid cells":"544.6","Medullary thymic epithelial cells":"645.7","Megakaryocyte progenitors":"626.4","Megakaryocyte-Erythroid progenitors":"1102.3","Myonuclei":"2577.1","Myosatellite cells":"503.5","Neutrophil progenitors":"822.6","Thymic myoid cells":"742.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"1102.3","Myocytes":"2577.1","Neuronal cells":"1755.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"5906.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Breast - Breast myoepithelial cells","Colon - Colon enteroendocrine cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1944","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"181003.3","Microglia and Neuropil":"208241.5","Neurons":"194018.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"12907","Protein tissue specific Intensity":{"cerebral cortex":"1290742.5"},"Antibody":["HPA016655"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cytoplasmic bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA016655":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNRG","Gene synonym":[],"Ensembl":"ENSG00000198553","Gene description":"Potassium channel regulator","Uniprot":["Q8N5I3"],"Chromosome":"13","Position":"50015254-50020922","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"fallopian tube":"33.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"51.8","Epicardial cells":"18.2","Epididymal efferent duct ciliated cells":"30.6","Fallopian tube ciliated cells":"110.8","Late primary spermatocytes":"29.0","Late spermatids":"20.3","Respiratory ciliated cells":"99.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"18.2","Ciliated cells":"110.8","Spermatogenic cell types":"29.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"6.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"4.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"34296","Protein cell type specific Intensity":{"Fallopian tube cells":"3429631.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"9259","Protein tissue specific Intensity":{"fallopian tube":"925900.1"},"Antibody":["HPA001027"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus","Vesicles","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA001027":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"}},{"Gene":"KCNT2","Gene synonym":["KCa4.2","SLICK","SLO2.1"],"Ensembl":"ENSG00000162687","Gene description":"Potassium sodium-activated channel subfamily T member 2","Uniprot":["Q6UVM3"],"Chromosome":"1","Position":"196225779-196609225","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"3.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"582.7","Brain inhibitory neurons":"211.0","Epicardial cells":"1150.7","Fibro-adipogenic progenitors":"268.3","Gonadotrophs":"602.7","Lactotrophs":"322.9","Mesothelial cells":"684.0","Oligodendrocyte progenitor cells":"388.3","Other brain neurons":"289.2","Thyrotrophs":"492.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1150.7","Glial cells":"582.7","Pituitary endocrine cells":"602.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"4.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA051218":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.67e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNU1","Gene synonym":["KCa5.1","Kcnma3","KCNMC1","Slo3"],"Ensembl":"ENSG00000215262","Gene description":"Potassium calcium-activated channel subfamily U member 1","Uniprot":["A8MYU2"],"Chromosome":"8","Position":"36784324-36936125","Protein class":["Human disease related genes","Predicted membrane proteins"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"testis":"6.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Adipocytes":"106.5","Early spermatids":"112.2","Late primary spermatocytes":"65.2","Late spermatids":"32.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Adipocytes":"106.5","Spermatogenic cell types":"112.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"5.1","choroid plexus epithelial cell":"4.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA063317"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":null,"Subcellular main location":["Plasma membrane","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA063317":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCNV2","Gene synonym":["Kv8.2"],"Ensembl":"ENSG00000168263","Gene description":"Potassium voltage-gated channel modifier subfamily V member 2","Uniprot":["Q8TDN2"],"Chromosome":"9","Position":"2717510-2730037","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel","Voltage-gated channel"],"Disease involvement":["Cone-rod dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"59","RNA tissue specific nTPM":{"retina":"268.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"732.8","Rod photoreceptor cells":"532.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neuronal cells":"732.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"90","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"9.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031131"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031131":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCP","Gene synonym":["CRIM2","FLJ33365","NET67"],"Ensembl":"ENSG00000135253","Gene description":"Kielin cysteine rich BMP regulator","Uniprot":["Q6ZWJ8"],"Chromosome":"7","Position":"128862042-128910719","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"kidney":"18.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"140.4","Enterocytes":"65.9","Epicardial cells":"86.4","Late spermatids":"52.8","Loop of henle epithelial cells":"105.1","Papillary tip epithelial cells":"101.0","Proximal tubule cells":"54.3","Renal collecting duct principal cells":"149.0","Renal connecting tubule cells":"60.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"86.4","Ductal cells":"149.0","Myocytes":"140.4","Renal nephron cells":"105.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"upper rhombic lip":"63.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"19.0"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"cerebellum":"3.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Gallbladder cancer":"13.0","Kidney cancer":"8.2"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"KCTD16","Gene synonym":["KIAA1317"],"Ensembl":"ENSG00000183775","Gene description":"Potassium channel tetramerization domain containing 16","Uniprot":["Q68DU8"],"Chromosome":"5","Position":"144170873-144485686","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"7.1","retina":"1.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"436.1","Brain excitatory neurons":"645.1","Brain inhibitory neurons":"589.1","Ependymal cells":"152.0","Loop of henle epithelial cells":"202.6","Oligodendrocyte progenitor cells":"491.9","Other brain neurons":"184.1","Proximal tubule cells":"141.4","Retinal bipolar cells":"121.8","Somatotrophs":"170.8","Thyrotrophs":"127.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"436.1","Glial cells":"491.9","Neuronal cells":"645.1","Renal nephron cells":"202.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"2240.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"3.6"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":3,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Vesicles","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA044590":null,"HPA050154":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.19e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KCTD17","Gene synonym":["FLJ12242"],"Ensembl":"ENSG00000100379","Gene description":"Potassium channel tetramerization domain containing 17","Uniprot":["Q8N5Z5"],"Chromosome":"22","Position":"37051739-37063390","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant","Dystonia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"147.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"27.6","Brain inhibitory neurons":"48.5","Corticotrophs":"34.4","Ependymal cells":"52.2","Late primary spermatocytes":"42.5","Late spermatids":"36.9","Lymphatic endothelial cells":"31.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"52.2","Neuronal cells":"48.5","Spermatogenic cell types":"42.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":39,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018459":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.68e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.75e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.99e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049310":null,"HPA053321":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-4"}},{"Gene":"KDELR2","Gene synonym":["ELP-1","ERD2.2"],"Ensembl":"ENSG00000136240","Gene description":"KDEL endoplasmic reticulum protein retention receptor 2","Uniprot":["P33947"],"Chromosome":"7","Position":"6445953-6484190","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["ER-Golgi transport","Protein transport","Transport"],"Molecular function":["Receptor"],"Disease involvement":["Disease variant","Osteogenesis imperfecta"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"406.1","Late primary spermatocytes":"486.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"486.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016459":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.30e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"}},{"Gene":"KDM3A","Gene synonym":["JHMD2A","JMJD1","JMJD1A","KIAA0742","TSGA"],"Ensembl":"ENSG00000115548","Gene description":"Lysine demethylase 3A","Uniprot":["Q9Y4C1"],"Chromosome":"2","Position":"86440647-86492716","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator","Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"115295.9","Keratinocytes":"152868.9","Large ducts":"352397.8","Pancreas epithelial cells":"461166.8","T-cells":"189353.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2824","Protein tissue specific Intensity":{"lymphoid tissue":"282368.3"},"Antibody":["HPA055543","HPA065162"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA055543":null,"HPA065162":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.48e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"}},{"Gene":"KDM4D","Gene synonym":["FLJ10251","JMJD2D"],"Ensembl":"ENSG00000186280","Gene description":"Lysine demethylase 4D","Uniprot":["Q6B0I6"],"Chromosome":"11","Position":"94973709-94999519","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Dioxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"testis":"31.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"41.2","Early spermatids":"92.2","Late primary spermatocytes":"244.9","Late spermatids":"55.4","Sertoli cells":"31.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"244.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"2.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"82","Protein tissue specific Intensity":{"lymphoid tissue":"8241.7"},"Antibody":["HPA055854","HPA064037"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA055854":null,"HPA064037":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"}},{"Gene":"KDM5B","Gene synonym":["CT31","JARID1B","PLU-1","PPP1R98","RBBP2H1A"],"Ensembl":"ENSG00000117139","Gene description":"Lysine demethylase 5B","Uniprot":["Q9UGL1"],"Chromosome":"1","Position":"202724495-202808487","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Dioxygenase","Oxidoreductase","Repressor"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"34.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Rod photoreceptor cells":"843.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"843.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Liver - Vascular endothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"816576.4","Pancreatic islets":"1811043.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"310261.4"},"Antibody":["HPA027179","HPA053723","CAB068193"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB068193":null,"HPA027179":null,"HPA053723":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.48e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"}},{"Gene":"KHDRBS3","Gene synonym":["Etle","etoile","SALP","SLM-2","SLM2","T-STAR"],"Ensembl":"ENSG00000131773","Gene description":"KH RNA binding domain containing, signal transduction associated 3","Uniprot":["O75525"],"Chromosome":"8","Position":"135457456-135656722","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","mRNA processing","Transcription","Transcription regulation"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"147.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"347.9","Breast lactating cells":"365.9","Early spermatids":"433.2","Late primary spermatocytes":"548.5","Microglia":"873.7","Oligodendrocyte progenitor cells":"831.5","Retinal bipolar cells":"450.4","Schwann cells":"656.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"873.7","Neuronal cells":"450.4","Spermatogenic cell types":"548.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"72.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"eosinophil":"1.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"1.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":55,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000275":null,"HPA000500":null,"HPA000981":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.85e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.37e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA015607":null,"HPA076313":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KIAA0408","Gene synonym":[],"Ensembl":"ENSG00000189367","Gene description":"KIAA0408","Uniprot":["Q6ZU52"],"Chromosome":"6","Position":"127438406-127459389","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"21.6","skeletal muscle":"26.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"7.8","Bergmann glia":"29.4","Brain excitatory neurons":"45.1","Brain inhibitory neurons":"43.4","Ependymal cells":"7.9","Myosatellite cells":"17.7","Oligodendrocyte progenitor cells":"24.6","Oligodendrocytes":"15.7","Other brain neurons":"39.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"29.4","Neuronal cells":"45.1","Stem cells":"17.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"8.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Neuroblastoma":"30.0"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":26,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA044035":null,"HPA053341":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA000846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":48,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Primary cilium","Basal body","Cytosol"],"Antibody RRID":{"HPA023057":null,"HPA023494":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.44e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"}},{"Gene":"KIAA0825","Gene synonym":["C5orf36","DKFZp686F0372","MGC34713"],"Ensembl":"ENSG00000185261","Gene description":"KIAA0825","Uniprot":["Q8IV33"],"Chromosome":"5","Position":"94150851-94618604","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"612.8","Ependymal cells":"1262.9","Lactotrophs":"447.8","Neutrophil progenitors":"474.8","Neutrophils":"2010.0","Respiratory ciliated cells":"825.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1262.9","Neuronal cells":"612.8","Neutrophils":"2010.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"1321.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"11.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"granulocytes":"11.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038030":null,"HPA038031":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":34,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Vesicles","Lipid droplets","Plasma membrane"],"Antibody RRID":{"HPA040946":null,"HPA048201":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"}},{"Gene":"KIAA2012","Gene synonym":[],"Ensembl":"ENSG00000182329","Gene description":"KIAA2012","Uniprot":[],"Chromosome":"2","Position":"202073255-202205188","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"fallopian tube":"8.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"98.8","Early spermatids":"76.6","Endometrial ciliated cells":"77.7","Ependymal cells":"770.3","Epididymal efferent duct ciliated cells":"171.2","Fallopian tube ciliated cells":"290.1","Respiratory ciliated cells":"495.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"770.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"835.8"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA077834":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.29e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"}},{"Gene":"KIF23","Gene synonym":["KNSL5","MKLP-1","MKLP1"],"Ensembl":"ENSG00000137807","Gene description":"Kinesin family member 23","Uniprot":["Q02241"],"Chromosome":"15","Position":"69414246-69448427","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Motor protein"],"Disease involvement":["Congenital dyserythropoietic anemia","Disease variant","Hereditary hemolytic anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"20.4","lymphoid tissue":"14.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"41.7","Differentiating spermatogonia":"34.8","Early primary spermatocytes":"45.5","Enteric transient amplifying cells":"33.7","Erythrocyte progenitors":"86.7","Extravillous trophoblasts":"49.4","Late primary spermatocytes":"60.8","Megakaryocyte progenitors":"36.1","Migrating cytotrophoblasts":"52.5","Monocyte progenitors":"74.3","Neutrophil progenitors":"36.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"86.7","Mononuclear phagocytes":"74.3","Spermatogenic cell types":"60.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"14.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"choroid plexus":"2.9"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"4.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"4.6","monocytes":"1.2","T-cells":"1.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Prostate - Smooth muscle cells","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"12385","Protein cell type specific Intensity":{"Granulosa cells":"1238504.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"948","Protein tissue specific Intensity":{"bone marrow":"94799.2"},"Antibody":["CAB010414","HPA045208","HPA068831"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Midbody ring","Mitotic spindle","Mid piece","Principal piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":78,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Midbody ring","Mitotic spindle","Mid piece","Principal piece","Annulus"],"Antibody RRID":{"CAB010414":null,"HPA045208":null,"HPA068831":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.72e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.37e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.80e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.19e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.08e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.82e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.85e-5"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"}},{"Gene":"KIF24","Gene synonym":["bA571F15.4","C9orf48","FLJ10933","FLJ43884"],"Ensembl":"ENSG00000186638","Gene description":"Kinesin family member 24","Uniprot":["Q5T7B8"],"Chromosome":"9","Position":"34252380-34329268","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"38.4","Differentiating spermatogonia":"41.2","Early primary spermatocytes":"46.0","Endometrial ciliated cells":"38.3","Ependymal cells":"76.2","Epicardial cells":"50.0","Erythrocyte progenitors":"35.6","Fallopian tube ciliated cells":"43.6","Late spermatids":"68.1","Respiratory ciliated cells":"60.4","Respiratory deuterosomal cells":"97.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"50.0","Ciliated cells":"97.4","Spermatogenic cell types":"68.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"93.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"basophil":"3.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"granulocytes":"3.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA020643":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.34e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.75e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"}},{"Gene":"KIF26B","Gene synonym":["FLJ10157"],"Ensembl":"ENSG00000162849","Gene description":"Kinesin family member 26B","Uniprot":["Q2KJY2"],"Chromosome":"1","Position":"245154985-245709432","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Developmental protein","Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"3.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"167.8","Brain inhibitory neurons":"183.5","Endometrial stromal cells":"217.7","Loop of henle epithelial cells":"156.0","Microglia":"244.9","Oligodendrocyte progenitor cells":"565.4","Other brain neurons":"141.3","Papillary tip epithelial cells":"212.1","Proximal tubule cells":"215.0","Renal collecting duct principal cells":"477.6","Renal connecting tubule cells":"237.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"477.6","Glial cells":"565.4","Stromal cells":"217.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"MGE interneuron":"774.3","oligodendrocyte precursor cell":"654.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"18","RNA blood cell specific nTPM":{"plasmacytoid DC":"1.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"dendritic cells":"1.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"18.4"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":2,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Plasma membrane","Cytokinetic bridge"],"Antibody RRID":{"HPA027709":null,"HPA028478":null,"HPA028561":null,"HPA028562":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.16e-7"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"KIF27","Gene synonym":["DKFZp434D0917"],"Ensembl":"ENSG00000165115","Gene description":"Kinesin family member 27","Uniprot":["Q86VH2"],"Chromosome":"9","Position":"83834099-83921465","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"24.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"265.0","Endometrial ciliated cells":"256.0","Ependymal cells":"312.1","Epididymal efferent duct ciliated cells":"266.1","Fallopian tube ciliated cells":"280.2","Neutrophils":"194.9","Respiratory ciliated cells":"296.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"312.1","Neutrophils":"194.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"281.1","ependymal cell":"337.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"16.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"16.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1052403.4","Distal tubules":"1521900.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"169","Protein tissue specific Intensity":{"lung":"16858.2"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.63e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"}},{"Gene":"KIF2A","Gene synonym":["HK2","KIF2"],"Ensembl":"ENSG00000068796","Gene description":"Kinesin family member 2A","Uniprot":["O00139"],"Chromosome":"5","Position":"62306162-62391025","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","Mitosis","Neurogenesis"],"Molecular function":["Developmental protein","Motor protein"],"Disease involvement":["Cancer-related genes","Disease variant","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Megakaryocytes":"457.4","Platelets":"1557.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Megakaryocytes":"457.4","Platelets":"1557.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"43041003.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"59279852.0"},"Antibody":["HPA004715","HPA004716"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Mitotic spindle","Centrosome","Basal body","Cytosol","Mid piece","Principal piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"350000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":42,"Subcellular main location":["Nucleoplasm","Nucleoli","Centrosome","Basal body","Annulus"],"Subcellular additional location":["Mitotic spindle","Cytosol","Mid piece","Principal piece"],"Antibody RRID":{"HPA004715":null,"HPA004716":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.89e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.96e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.38e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"KIF2B","Gene synonym":[],"Ensembl":"ENSG00000141200","Gene description":"Kinesin family member 2B","Uniprot":["Q8N4N8"],"Chromosome":"17","Position":"53822927-53825193","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"705","RNA tissue specific nTPM":{"testis":"70.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"127","RNA single cell type specific nCPM":{"Early spermatids":"817.0","Late primary spermatocytes":"239.8","Late spermatids":"765.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"171","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"817.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":5,"Subcellular main location":["Microtubules","Cytokinetic bridge","Mitotic spindle"],"Subcellular additional location":["Nucleoli","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA023081":null,"HPA023103":null,"HPA024795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KIF2C","Gene synonym":["CT139","KNSL6","MCAK"],"Ensembl":"ENSG00000142945","Gene description":"Kinesin family member 2C","Uniprot":["Q99661"],"Chromosome":"1","Position":"44739818-44767767","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Chromosome partition","Mitosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"31.1","lymphoid tissue":"34.8","testis":"72.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"3084.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3084.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"2.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":21,"Subcellular main location":["Nucleoplasm","Midbody","Centrosome"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB080091":null,"HPA006219":null,"HPA079172":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.25e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.49e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.27e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.57e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.26e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.70e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"}},{"Gene":"KIF3A","Gene synonym":["FLA10","KLP-20"],"Ensembl":"ENSG00000131437","Gene description":"Kinesin family member 3A","Uniprot":["Q9Y496"],"Chromosome":"5","Position":"132692628-132737638","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"40.4","retina":"31.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"194.0","Brain inhibitory neurons":"190.0","Gonadotrophs":"202.7","Other brain neurons":"195.2","Respiratory ciliated cells":"204.6","Retinal horizontal cells":"220.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"204.6","Neuronal cells":"220.4","Pituitary endocrine cells":"202.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"basophil":"68.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"68.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":31,"Subcellular main location":["Nucleoplasm","Primary cilium","Basal body","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB037085":null,"HPA063063":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.47e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"}},{"Gene":"KIF3B","Gene synonym":["FLA8","KIAA0359","KLP-11"],"Ensembl":"ENSG00000101350","Gene description":"Kinesin family member 3B","Uniprot":["O15066"],"Chromosome":"20","Position":"32277651-32335011","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Ciliopathy","Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"156.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"18223045.3","Neurons":"19182730.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"18320687.1"},"Antibody":["HPA007119"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium tip","Cytosol","Connecting piece","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":15,"Subcellular main location":["Nucleoplasm","Primary cilium tip","Flagellar centriole"],"Subcellular additional location":["Cytosol","Connecting piece"],"Antibody RRID":{"HPA007119":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"KIF4B","Gene synonym":[],"Ensembl":"ENSG00000226650","Gene description":"Kinesin family member 4B","Uniprot":["Q2VIQ3"],"Chromosome":"5","Position":"155013755-155018141","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding","Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"33","RNA tissue specific nTPM":{"testis":"3.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"2.1","Early spermatids":"4.5","Late primary spermatocytes":"22.4","Late spermatids":"6.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"22.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Nucleoplasm","Midbody"],"Subcellular additional location":["Acrosome","Equatorial segment","Mid piece","Principal piece"],"Antibody RRID":{"HPA034745":null,"HPA034746":null,"HPA061583":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KIF5B","Gene synonym":["KNS","KNS1","uKHC"],"Ensembl":"ENSG00000170759","Gene description":"Kinesin family member 5B","Uniprot":["P33176"],"Chromosome":"10","Position":"32009015-32056425","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"140000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":82,"Subcellular main location":["Centriolar satellite","Cytosol"],"Subcellular additional location":["End piece"],"Antibody RRID":{"CAB009846":null,"HPA037589":null,"HPA037590":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"}},{"Gene":"KIF6","Gene synonym":["C6orf102","dJ1043E3.1","dJ137F1.4","dJ188D3.1","DKFZp451I2418","MGC33317"],"Ensembl":"ENSG00000164627","Gene description":"Kinesin family member 6","Uniprot":["Q6ZMV9"],"Chromosome":"6","Position":"39329990-39725408","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.7","fallopian tube":"3.6","testis":"4.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"134.8","Ependymal cells":"454.0","Epididymal efferent duct ciliated cells":"81.8","Fallopian tube ciliated cells":"158.9","Oligodendrocytes":"325.1","Respiratory ciliated cells":"321.7","Rod photoreceptor cells":"85.4","Thyrotrophs":"85.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"454.0","Glial cells":"325.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"477.7","oligodendrocyte":"443.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.5","Skin Cutaneous Melanoma (TCGA)":"3.9","Uterine Corpus Endometrial Carcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"skin cancer":"9.6"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA038811":null,"HPA058624":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"}},{"Gene":"KIF9","Gene synonym":["MGC104186"],"Ensembl":"ENSG00000088727","Gene description":"Kinesin family member 9","Uniprot":["Q9HAQ2"],"Chromosome":"3","Position":"47227998-47283451","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"107.2","testis":"60.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"637.2","Endometrial ciliated cells":"460.6","Epididymal efferent duct ciliated cells":"753.0","Fallopian tube ciliated cells":"455.4","Late primary spermatocytes":"1062.5","Respiratory ciliated cells":"378.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"753.0","Spermatogenic cell types":"1062.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"154.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"15718","Protein cell type specific Intensity":{"Fallopian tube cells":"1571825.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"902557.3"},"Antibody":["HPA022031","HPA022033","HPA030429"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Primary cilium","Primary cilium tip","Cytosol","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":44,"Subcellular main location":["Primary cilium","Primary cilium tip","Cytosol"],"Subcellular additional location":["Mid piece"],"Antibody RRID":{"HPA022031":null,"HPA022033":null,"HPA030429":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.51e-7"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.28e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.19e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"}},{"Gene":"KIFC3","Gene synonym":[],"Ensembl":"ENSG00000140859","Gene description":"Kinesin family member C3","Uniprot":["Q9BVG8"],"Chromosome":"16","Position":"57758217-57863053","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Motor protein"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"168.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"594.1","Enterocytes":"295.0","Esophageal apical cells":"605.2","Late spermatids":"639.4","Loop of henle epithelial cells":"289.8","Platelets":"268.0","Proximal tubule cells":"402.6","Rod photoreceptor cells":"1050.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"605.2","Neuronal cells":"1050.4","Spermatogenic cell types":"639.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"200.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"620968.0","Keratinocytes":"584907.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"14","Protein tissue specific Intensity":{"salivary gland":"1393.1"},"Antibody":["HPA021240"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":75,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021240":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"}},{"Gene":"KISS1","Gene synonym":[],"Ensembl":"ENSG00000170498","Gene description":"KiSS-1 metastasis suppressor","Uniprot":["Q15726"],"Chromosome":"1","Position":"204190341-204196491","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Hypogonadotropic hypogonadism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"30","RNA tissue specific nTPM":{"placenta":"220.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"40","RNA single cell type specific nCPM":{"Syncytiotrophoblasts":"1419.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"40","RNA single cell type group specific nCPM":{"Trophoblast cells":"1419.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"2.6","deep-layer near-projecting":"2.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"25.5"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"hypothalamus":"19.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Adrenocortical cancer":"170.5"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Prostate - Prostate basal glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017775","HPA035542"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":"Secreted in female reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"590000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 13: Syncytiotrophoblasts - Placental remodeling & endocrine func.","Interactions":7,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB017775":null,"HPA035542":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"KIZ","Gene synonym":["C20orf19","HT013","NCRNA00153","PLK1S1"],"Ensembl":"ENSG00000088970","Gene description":"Kizuna centrosomal protein","Uniprot":["Q2M2Z5"],"Chromosome":"20","Position":"21125983-21246622","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"290.4","Oligodendrocyte progenitor cells":"298.8","Renal collecting duct principal cells":"252.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"298.8","Spermatogenic cell types":"290.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1866","Protein cell type specific Intensity":{"Fallopian tube cells":"186644.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"185638.0"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"}},{"Gene":"KLB","Gene synonym":[],"Ensembl":"ENSG00000134962","Gene description":"Klotho beta","Uniprot":["Q86Z14"],"Chromosome":"4","Position":"39406930-39451533","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"18.4","liver":"16.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"193.2","Goblet cells":"22.0","Hepatocytes":"54.1","Late primary spermatocytes":"73.8","Neuroendocrine cells":"24.9","Pancreatic acinar cells":"32.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"193.2","Hepatocytes":"54.1","Spermatogenic cell types":"73.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"splatter":"5.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"12","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"14.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"8.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Liver - Hepatocytes","Minor Salivary Gland - Adipocytes (Minor salivary gland)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"34767.1","Pancreas epithelial cells":"59823.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA021136"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"220000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":1,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA021136":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KLF17","Gene synonym":["FLJ40160","Zfp393","ZNF393"],"Ensembl":"ENSG00000171872","Gene description":"KLF transcription factor 17","Uniprot":["Q5JT82"],"Chromosome":"1","Position":"44118821-44135140","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"8.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"249.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"88","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"249.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"1.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"20","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"7.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Adrenocortical cancer":"3.6"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KLF4","Gene synonym":["EZF","GKLF"],"Ensembl":"ENSG00000136826","Gene description":"KLF transcription factor 4","Uniprot":["O43474"],"Chromosome":"9","Position":"107484852-107490482","Protein class":["Cancer-related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skin 1":"185.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast secretory cells":"465.6","Colonocytes":"645.1","Esophageal apical cells":"600.4","Goblet cells":"916.9","Ocular epithelial cells":"494.6","Suprabasal keratinocytes":"583.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Goblet cells":"916.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"101.2","fibroblast":"36.6","vascular associated smooth muscle cell":"47.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"1.0","non-classical monocyte":"1.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Microtubules","Cytosol"],"Antibody RRID":{"HPA002926":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.11e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"}},{"Gene":"KLF5","Gene synonym":["BTEB2","CKLF","IKLF"],"Ensembl":"ENSG00000102554","Gene description":"KLF transcription factor 5","Uniprot":["Q13887"],"Chromosome":"13","Position":"73054976-73077541","Protein class":["Cancer-related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"226.7","skin 1":"221.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"804.1","Colonocytes":"990.8","Endometrial glandular cells":"1230.0","Endometrial luminal cells":"900.8","Epididymal basal cells":"1194.1","Esophageal apical cells":"1306.4","Esophageal suprabasal cells":"909.1","Ocular epithelial cells":"1697.8","Suprabasal keratinocytes":"1076.7","Urothelial cells":"1022.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1306.4","Barrier epithelial cells":"1697.8","Basal cells":"1194.1","Glandular cells":"1230.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"61.3","medium spiny neuron":"50.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"20","RNA blood cell specific nTPM":{"basophil":"24.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"140","RNA blood lineage specific nTPM":{"granulocytes":"24.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Colon enterocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary gland basal cells","Prostate - Urothelial cells","Skin - Keratinocyte (other)","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"spinal cord":"30.7"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"756943.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040398"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":38,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Vesicles"],"Antibody RRID":{"HPA040398":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.49e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.40e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"}},{"Gene":"KLHDC10","Gene synonym":["KIAA0265","slim"],"Ensembl":"ENSG00000128607","Gene description":"Kelch domain containing 10","Uniprot":["Q6PID8"],"Chromosome":"7","Position":"130070534-130135705","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Spleen - Endothelial cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"914603.7","Fallopian tube cells":"868229.9","Hepatocytes":"2701518.1","Macrophages":"1721888.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020119"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA020119":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"}},{"Gene":"KLHDC3","Gene synonym":["dJ20C7.3","hPeas","PEAS"],"Ensembl":"ENSG00000124702","Gene description":"Kelch domain containing 3","Uniprot":["Q9BQ90"],"Chromosome":"6","Position":"43014103-43021298","Protein class":["Predicted intracellular proteins"],"Biological process":["Meiosis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"370.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"2541.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2541.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":28,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA030131":null,"HPA030132":null,"HPA030133":null,"HPA030134":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.20e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.14e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.64e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"}},{"Gene":"KLHDC4","Gene synonym":["DKFZp434G0522"],"Ensembl":"ENSG00000104731","Gene description":"Kelch domain containing 4","Uniprot":["Q8TBB5"],"Chromosome":"16","Position":"87696485-87765992","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"130.0","pDCs":"113.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":11,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Kinetochore"],"Antibody RRID":{"HPA041665":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"}},{"Gene":"KLHDC7A","Gene synonym":["FLJ38753"],"Ensembl":"ENSG00000179023","Gene description":"Kelch domain containing 7A","Uniprot":["Q5VTJ3"],"Chromosome":"1","Position":"18480930-18485974","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"18.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"10.5","Conjunctival goblet cells":"7.8","Epididymal efferent duct absorptive cells":"7.2","Epididymal efferent duct ciliated cells":"6.7","Esophageal apical cells":"6.5","Foveolar cells":"15.8","Hepatocytes":"8.5","Loop of henle epithelial cells":"7.1","Papillary tip epithelial cells":"7.3","Proximal tubule cells":"6.8","Renal collecting duct principal cells":"7.2","Respiratory ciliated cells":"9.7","Respiratory secretory cells":"6.3","Salivary duct cells":"8.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"10.5","Ductal cells":"8.5","Gastric glandular cells":"15.8","Hepatocytes":"8.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"9.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"21.5"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"12","RNA brain regional specific nTPM":{"choroid plexus":"18.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"9.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 68: Foveolar cells - Mucosal defense","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA056616":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":2,"Subcellular main location":["Nucleoplasm","Nucleoli","Nucleoli rim","Mitotic chromosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA043197":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.71e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"}},{"Gene":"KLHL10","Gene synonym":["FLJ32662"],"Ensembl":"ENSG00000161594","Gene description":"Kelch like family member 10","Uniprot":["Q6JEL2"],"Chromosome":"17","Position":"41835685-41848384","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"37","RNA tissue specific nTPM":{"testis":"55.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"66.7","Early spermatids":"358.8","Late primary spermatocytes":"223.7","Late spermatids":"900.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"900.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"605","Protein cell type specific Intensity":{"Alveolar cell types":"60455.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA067538"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":8,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA067538":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KLHL11","Gene synonym":["FLJ10572"],"Ensembl":"ENSG00000178502","Gene description":"Kelch like family member 11","Uniprot":["Q9NVR0"],"Chromosome":"17","Position":"41848518-41865423","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"158.2","Late spermatids":"58.6","Retinal horizontal cells":"34.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"158.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"145532.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023021","HPA052403","HPA054269"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA023021":null,"HPA052403":null,"HPA054269":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"}},{"Gene":"KLHL41","Gene synonym":["KBTBD10","Krp1","SARCOSIN"],"Ensembl":"ENSG00000239474","Gene description":"Kelch like family member 41","Uniprot":["O60662"],"Chromosome":"2","Position":"169509702-169526258","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Nemaline myopathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"42","RNA tissue specific nTPM":{"skeletal muscle":"4718.5","tongue":"3245.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Thymic myoid cells":"492.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Stromal cells":"492.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"27.1","Prostate Adenocarcinoma (TCGA)":"7.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"Sarcoma":"16.3"},"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"734600053.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"180137070.7"},"Antibody":["HPA021165","HPA021753","HPA021760"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":10,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA021165":null,"HPA021753":null,"HPA021760":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KLHL7","Gene synonym":["KLHL6","RP42","SBBI26"],"Ensembl":"ENSG00000122550","Gene description":"Kelch like family member 7","Uniprot":["Q8IXQ5"],"Chromosome":"7","Position":"23105758-23177914","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"47.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"302.5","Early spermatids":"757.5","Late primary spermatocytes":"295.8","Late spermatids":"382.0","Oocytes":"248.7","Sertoli cells":"322.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"322.5","Spermatogenic cell types":"757.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"1297308.2","Neurons":"390610.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5370","Protein tissue specific Intensity":{"lymphoid tissue":"537029.5"},"Antibody":["HPA029491","HPA029492"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":10,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA029491":null,"HPA029492":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.70e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.25e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"}},{"Gene":"KLK15","Gene synonym":["ACO","HSRNASPH","prostinogen"],"Ensembl":"ENSG00000174562","Gene description":"Kallikrein related peptidase 15","Uniprot":["Q9H2R5"],"Chromosome":"19","Position":"50825289-50837213","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"2.1","salivary gland":"3.7","testis":"1.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"6.9","Early primary spermatocytes":"15.5","Early spermatids":"6.0","Enteric stem cells":"5.5","Goblet cells":"45.0","Late primary spermatocytes":"17.6","Late spermatids":"13.9","Retinal horizontal cells":"8.0","Salivary duct cells":"14.2","Salivary ionocytes":"7.6","Undifferentiated spermatogonia":"6.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"14.2","Goblet cells":"45.0","Spermatogenic cell types":"17.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"38.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"2.4"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019802"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":84,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019802":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KLRK1","Gene synonym":["CD314","D12S2489E","KLR","NKG2-D","NKG2D"],"Ensembl":"ENSG00000213809","Gene description":"Killer cell lectin like receptor K1","Uniprot":["P26718"],"Chromosome":"12","Position":"10372353-10391874","Protein class":["Cancer-related genes","CD markers","Predicted membrane proteins","Transporters"],"Biological process":["Adaptive immunity","Differentiation","Immunity","Innate immunity"],"Molecular function":["Receptor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"20.8","lymphoid tissue":"39.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"NK-cells":"22.5","Oligodendrocyte progenitor cells":"25.1","Oligodendrocytes":"8.3","T-cells":"12.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Glial cells":"25.1","NK-cells":"22.5","T-cells":"12.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"leukocyte":"279.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"40","RNA blood cell specific nTPM":{"gdT-cell":"287.0","MAIT T-cell":"111.2","memory CD8 T-cell":"260.3","naive CD8 T-cell":"258.6","NK-cell":"335.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"49","RNA blood lineage specific nTPM":{"NK-cells":"335.6","T-cells":"287.0"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"15","RNA cell line specific nTPM":{"Leukemia":"9.9","lymphoma":"31.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"41000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":5,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB021896":null,"HPA068877":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.53e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.13e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"KMO","Gene synonym":[],"Ensembl":"ENSG00000117009","Gene description":"Kynurenine 3-monooxygenase","Uniprot":["O15229"],"Chromosome":"1","Position":"241532134-241595642","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Pyridine nucleotide biosynthesis"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"kidney":"29.3","liver":"85.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"65.5","cDC":"126.8","Endometrial glandular cells":"144.5","Hepatocytes":"108.3","Kupffer cells":"191.7","Macrophages":"203.4","monocytes":"288.9","pDCs":"64.6","Salivary ionocytes":"66.9","Syncytiotrophoblasts":"453.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"126.8","Glandular cells":"144.5","Mononuclear phagocytes":"288.9","Trophoblast cells":"453.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"CGE interneuron":"71.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"17.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"100","RNA blood cell specific nTPM":{"classical monocyte":"11.1","intermediate monocyte":"32.3","memory B-cell":"36.2","myeloid DC":"11.3","naive B-cell":"42.2","non-classical monocyte":"34.0","plasmacytoid DC":"24.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"122","RNA blood lineage specific nTPM":{"B-cells":"42.2","dendritic cells":"24.4","monocytes":"34.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"26.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031115":null,"HPA056942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"}},{"Gene":"KNCN","Gene synonym":["FLJ32011","KINO","L5"],"Ensembl":"ENSG00000162456","Gene description":"Kinocilin","Uniprot":["A6PVL3"],"Chromosome":"1","Position":"46545641-46551647","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"1.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"14.7","Late spermatids":"53.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"53.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"7.1","mammillary body":"5.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pituitary gland - Thyrotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KNSTRN","Gene synonym":["C15orf23","FLJ14502","kinastrin","SKAP","TRAF4AF1"],"Ensembl":"ENSG00000128944","Gene description":"Kinetochore localized astrin (SPAG5) binding protein","Uniprot":["Q9Y448"],"Chromosome":"15","Position":"40382721-40394288","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"59.0","thyroid gland":"51.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Early spermatids":"405.3","Late primary spermatocytes":"260.5","Late spermatids":"939.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"939.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Mitotic cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1501","Protein cell type specific Intensity":{"Granulosa cells":"150059.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5158","Protein tissue specific Intensity":{"bone marrow":"515819.6"},"Antibody":["HPA042027"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane","Mitotic spindle","Centriolar satellite"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":40,"Subcellular main location":["Mitotic spindle","Centriolar satellite"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA042027":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.79e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.28e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.92e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.28e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.08e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"}},{"Gene":"KPNA2","Gene synonym":["IPOA1","PTAC58","QIP2","RCH1","SRP1alpha"],"Ensembl":"ENSG00000182481","Gene description":"Karyopherin subunit alpha 2","Uniprot":["P52292"],"Chromosome":"17","Position":"68035636-68047364","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"195.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"805.7","Extravillous trophoblasts":"357.8","Late primary spermatocytes":"1344.4","Late spermatids":"324.4","Oocytes":"534.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"534.2","Spermatogenic cell types":"1344.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"7810773.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"2975022.7","bone marrow":"3145217.7"},"Antibody":["CAB015460","HPA041270"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":203,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB015460":null,"HPA041270":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.31e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.93e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.74e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.53e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.25e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.62e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.68e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"KPNA3","Gene synonym":["hSRP1","IPOA4","SRP1gamma","SRP4"],"Ensembl":"ENSG00000102753","Gene description":"Karyopherin subunit alpha 3","Uniprot":["O00505"],"Chromosome":"13","Position":"49699320-49792682","Protein class":["Human disease related genes","Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","Protein transport","Transport","Viral penetration into host nucleus","Virus entry into host cell"],"Molecular function":null,"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"136.2","tongue":"88.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"428.6","Rod photoreceptor cells":"382.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"26739455.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046852","HPA077643"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":112,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA046852":null,"HPA077643":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"}},{"Gene":"KPNA5","Gene synonym":["IPOA6","SRP6"],"Ensembl":"ENSG00000196911","Gene description":"Karyopherin subunit alpha 5","Uniprot":["O15131"],"Chromosome":"6","Position":"116681187-116741867","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"39.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"386.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"386.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"5469433.7","T-cells":"2365799.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"326194.8"},"Antibody":["CAB026464","HPA054037"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":32,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB026464":null,"HPA054037":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.30e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"}},{"Gene":"KRBOX1","Gene synonym":[],"Ensembl":"ENSG00000240747","Gene description":"KRAB box domain containing 1","Uniprot":["C9JBD0"],"Chromosome":"3","Position":"42936386-42942792","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"20","RNA tissue specific nTPM":{"testis":"191.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"5.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"2.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"NK-cell":"4.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"NK-cells":"4.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"325","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"40690.8","Microglia and Neuropil":"25802.6","Neurons":"31066.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046901"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA046901":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"}},{"Gene":"KRI1","Gene synonym":["FLJ12949"],"Ensembl":"ENSG00000129347","Gene description":"KRI1 homolog","Uniprot":["Q8N9T8"],"Chromosome":"19","Position":"10553085-10566031","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 49: Non-specific - Transcription","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":22,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA043110":null,"HPA043574":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.36e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1200000","Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":null,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB017091":null,"HPA012050":null,"HPA016959":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - 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NK-cells (Lung)","Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"7199958.2","Large ducts":"22777584.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"7340570.8"},"Antibody":["HPA065523"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":22,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA065523":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"29000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 9: Skin - Hair follicle development","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":30,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049778":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 9: Skin - Hair follicle development","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":44,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039798":null,"HPA049778":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KRTAP5-7","Gene synonym":["KRTAP5-3","KRTAP5.7"],"Ensembl":"ENSG00000244411","Gene description":"Keratin associated protein 5-7","Uniprot":["Q6L8G8"],"Chromosome":"11","Position":"71527267-71528669","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skin 1":"4.8","testis":"1.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1.1","Kupffer cells":"1.0","Late primary spermatocytes":"1.6","Late spermatids":"7.4","Retinal amacrine cells":"2.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"2.1","Spermatogenic cell types":"7.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"1.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":50,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KRTCAP2","Gene synonym":["KCP2"],"Ensembl":"ENSG00000163463","Gene description":"Keratinocyte associated protein 2","Uniprot":["Q8N6L1"],"Chromosome":"1","Position":"155169408-155173475","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"119.6","Gastric chief cells":"286.1","Late primary spermatocytes":"125.4","Parietal cells":"198.0","Plasma cells":"131.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"286.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"13.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.83e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.16e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.36e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"}},{"Gene":"KSR2","Gene synonym":["FLJ25965"],"Ensembl":"ENSG00000171435","Gene description":"Kinase suppressor of ras 2","Uniprot":["Q6VAB6"],"Chromosome":"12","Position":"117453012-117968990","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"5.4","pituitary gland":"7.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"425.9","Brain inhibitory neurons":"338.2","Corticotrophs":"531.7","Gonadotrophs":"642.3","Lactotrophs":"1078.3","Other brain neurons":"278.5","Renal collecting duct principal cells":"737.2","Retinal amacrine cells":"263.7","Somatotrophs":"887.3","Thyrotrophs":"906.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"737.2","Neuronal cells":"425.9","Pituitary endocrine cells":"1078.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":18,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035536":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"KTN1","Gene synonym":["CG1","KIAA0004","KNT"],"Ensembl":"ENSG00000126777","Gene description":"Kinectin 1","Uniprot":["Q86UP2"],"Chromosome":"14","Position":"55559072-55701526","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"36000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":32,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB015331":null,"HPA003178":null,"HPA017876":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.21e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.31e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.55e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"}},{"Gene":"KXD1","Gene synonym":["BORCS4","C19orf50","FLJ25480","KXDL","MGC2749"],"Ensembl":"ENSG00000105700","Gene description":"KxDL motif containing 1","Uniprot":["Q9BQD3"],"Chromosome":"19","Position":"18557762-18569387","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"236.1","Hofbauer cells":"146.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"236.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"6352","Protein cell type specific Intensity":{"Macrophages":"590693.3","Pancreas epithelial cells":"679668.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041507","HPA041599"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":90,"Subcellular main location":["Nucleoli fibrillar center","Centrosome","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041507":null,"HPA041599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"}},{"Gene":"KYNU","Gene synonym":[],"Ensembl":"ENSG00000115919","Gene description":"Kynureninase","Uniprot":["Q16719"],"Chromosome":"2","Position":"142877657-143055833","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Pyridine nucleotide biosynthesis"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"82.6","urinary bladder":"48.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"234.9","cDC":"837.5","Endometrial secretory cells":"330.9","Kupffer cells":"259.3","Macrophages":"585.3","Megakaryocyte-Erythroid progenitors":"251.1","monocytes":"1977.3","Syncytiotrophoblasts":"408.3","Urothelial cells":"346.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"837.5","Mononuclear phagocytes":"1977.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"15","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"180.0","endothelial cell":"66.6","leukocyte":"143.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"17","RNA blood cell specific nTPM":{"classical monocyte":"109.6","intermediate monocyte":"142.9","memory B-cell":"73.8","myeloid DC":"111.3","naive B-cell":"51.6","non-classical monocyte":"124.0","plasmacytoid DC":"77.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"19","RNA blood lineage specific nTPM":{"B-cells":"73.8","dendritic cells":"111.3","monocytes":"142.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Heart muscle - Macrophages","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skeletal muscle - Macrophages","Stomach - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"21102996.3","Hepatocytes":"38333072.5","Proximal tubules":"24266539.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"32613303.3"},"Antibody":["HPA031686"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"550000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA031686":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.56e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.51e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.85e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"}},{"Gene":"L2HGDH","Gene synonym":["C14orf160","FLJ12618"],"Ensembl":"ENSG00000087299","Gene description":"L-2-hydroxyglutarate dehydrogenase","Uniprot":["Q9H9P8"],"Chromosome":"14","Position":"50237563-50312229","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"18.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"211.2","Proximal tubule cells":"118.2","Rod photoreceptor cells":"157.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"211.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"8.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA065409","HPA069708"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA065409":null,"HPA069708":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.20e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"LACTB","Gene synonym":["FLJ14902","MRPL56"],"Ensembl":"ENSG00000103642","Gene description":"Lactamase beta","Uniprot":["P83111"],"Chromosome":"15","Position":"63121833-63142061","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase","Protease"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"151.9","Mast cells":"128.9","monocytes":"152.8","Neutrophils":"183.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"183.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Macrophages","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036361","HPA036362"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane","Mitotic chromosome","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":31,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear membrane","Mitotic chromosome","Cytosol"],"Antibody RRID":{"HPA036361":null,"HPA036362":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"LACTB2","Gene synonym":["CGI-83"],"Ensembl":"ENSG00000147592","Gene description":"Lactamase beta 2","Uniprot":["Q53H82"],"Chromosome":"8","Position":"70635318-70669185","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Endonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"89.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"251.2","Late primary spermatocytes":"666.3","Tuft cells":"172.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"666.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"16595418.3","Proximal tubules":"33281163.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044391","HPA053040"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"93000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus"],"Antibody RRID":{"HPA044391":null,"HPA053040":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.66e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"}},{"Gene":"LAMB4","Gene synonym":[],"Ensembl":"ENSG00000091128","Gene description":"Laminin subunit beta 4","Uniprot":["A4D0S4"],"Chromosome":"7","Position":"108023548-108130361","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"skin 1":"36.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"100.7","Cone photoreceptor cells":"20.7","Epicardial cells":"29.6","Late spermatids":"18.2","Loop of henle epithelial cells":"31.9","Mesothelial cells":"49.3","Migrating cytotrophoblasts":"28.5","Ocular epithelial cells":"18.4","Parietal cells":"19.4","Renal collecting duct intercalated cells":"19.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"49.3","Basal cells":"100.7","Renal nephron cells":"31.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"7.8"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"5.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"Bladder cancer":"2.8","cervical cancer":"1.3","Uterine cancer":"2.8"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA020242":null,"HPA024247":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LAMC2","Gene synonym":["BM600-100kDa","EBR2","EBR2A","kalinin-105kDa","LAMB2T","LAMNB2","nicein-100kDa"],"Ensembl":"ENSG00000058085","Gene description":"Laminin subunit gamma 2","Uniprot":["Q13753"],"Chromosome":"1","Position":"183186238-183245127","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Heparin-binding"],"Disease involvement":["Epidermolysis bullosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"urinary bladder":"36.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Epididymal basal cells":"5218.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Basal cells":"5218.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"8.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"403.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"511.2"},"RNA tissue cell type enrichment":["Breast - Breast myoepithelial cells","Liver - Cholangiocytes","Pancreas - Ductal cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"88691573.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"60706913.7"},"Antibody":["CAB004257","HPA024638","HPA046539","HPA046540","CAB078165"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Golgi apparatus"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Cell adhesion","CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"27000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":4,"Subcellular main location":["Endoplasmic reticulum","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB004257":null,"CAB078165":null,"HPA024638":null,"HPA046539":null,"HPA046540":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.73e-6"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.41e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"}},{"Gene":"LAMP3","Gene synonym":["CD208","DC-LAMP","DCLAMP","LAMP","TSC403"],"Ensembl":"ENSG00000078081","Gene description":"Lysosomal associated membrane protein 3","Uniprot":["Q9UQV4"],"Chromosome":"3","Position":"183122215-183163839","Protein class":["CD markers","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Host-virus interaction","Immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"lung":"207.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Alveolar cells type 2":"925.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Alveolar cells":"925.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"5.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"5.6","T-cells":"4.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - T-cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"461451","Protein cell type specific Intensity":{"Alveolar cell types":"46145069.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"3758053.9"},"Antibody":["CAB025133","HPA051467"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":32,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB025133":null,"HPA051467":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"}},{"Gene":"LANCL1","Gene synonym":["GPR69A","p40"],"Ensembl":"ENSG00000115365","Gene description":"LanC like glutathione S-transferase 1","Uniprot":["O43813"],"Chromosome":"2","Position":"210427131-210477652","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"161.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Lactotrophs":"221.7","Oligodendrocytes":"662.4","Pituicytes\/FSCs":"200.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"662.4","Pituitary endocrine cells":"221.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"992.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"62130637.2"},"Antibody":["HPA034994"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Primary cilium","Basal body","Flagellar centriole","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"22000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":23,"Subcellular main location":["Microtubules","Primary cilium","Basal body","End piece"],"Subcellular additional location":["Flagellar centriole"],"Antibody RRID":{"HPA034994":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"LANCL2","Gene synonym":["GPR69B","TASP"],"Ensembl":"ENSG00000132434","Gene description":"LanC like glutathione S-transferase 2","Uniprot":["Q9NS86"],"Chromosome":"7","Position":"55365337-55433737","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"85.3","Testicular Germ Cell Tumor (TCGA)":"21.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"21216859.8","Microglia and Neuropil":"21377525.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"59375461.1"},"Antibody":["HPA019711","HPA029535"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":7,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019711":null,"HPA029535":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.33e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.84e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.55e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"}},{"Gene":"LARGE2","Gene synonym":["FLJ35207","GYLTL1B","PP5656"],"Ensembl":"ENSG00000165905","Gene description":"LARGE xylosyl- and glucuronyltransferase 2","Uniprot":["Q8N3Y3"],"Chromosome":"11","Position":"45921621-45929096","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Multifunctional enzyme","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"34.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Breast lactating cells":"289.7","Cytotrophoblasts":"331.3","Migrating cytotrophoblasts":"95.2","Syncytiotrophoblasts":"139.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Secretory cells":"289.7","Trophoblast cells":"331.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"28.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"13","RNA brain regional specific nTPM":{"choroid plexus":"26.5"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"1.4","naive B-cell":"2.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"2.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"164620.2","Pancreatic islets":"201290.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"67","Protein tissue specific Intensity":{"intestine":"6680.4"},"Antibody":["HPA056621"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.21e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.70e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"}},{"Gene":"LARP1B","Gene synonym":["DKFZp434K245","DKFZp686E0316","FLJ10378","LARP2"],"Ensembl":"ENSG00000138709","Gene description":"La ribonucleoprotein 1B","Uniprot":["Q659C4"],"Chromosome":"4","Position":"128061286-128222931","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"612.9","Late primary spermatocytes":"570.4","Late spermatids":"744.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"744.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"2957973.6","Pancreas epithelial cells":"816710.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"621477.6"},"Antibody":["HPA036280"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":45,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036280":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.95e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.05e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"}},{"Gene":"LATS2","Gene synonym":[],"Ensembl":"ENSG00000150457","Gene description":"Large tumor suppressor kinase 2","Uniprot":["Q9NRM7"],"Chromosome":"13","Position":"20973036-21061586","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"250.1","Neutrophils":"446.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"446.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"124.1","fibroblast":"123.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039191","HPA049037"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":72,"Subcellular main location":["Centriolar satellite","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039191":null,"HPA049037":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.37e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.96e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.53e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"}},{"Gene":"LCA5L","Gene synonym":["C21orf13","MGC33295"],"Ensembl":"ENSG00000157578","Gene description":"Lebercilin LCA5 like","Uniprot":["O95447"],"Chromosome":"21","Position":"39405728-39445805","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"103.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"1231.7","Late primary spermatocytes":"1581.2","Late spermatids":"684.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1581.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"145.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"445","Protein cell type specific Intensity":{"Fallopian tube cells":"44480.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"14895","Protein tissue specific Intensity":{"Stomach":"1489516.4"},"Antibody":["HPA032010"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear speckles","Cytosol","Flagellar centriole","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":["Nucleoplasm","Nuclear speckles","Flagellar centriole","Mid piece"],"Subcellular additional location":["Cytosol","Principal piece","End piece"],"Antibody RRID":{"HPA032010":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"}},{"Gene":"LCMT1","Gene synonym":["CGI-68","PPMT1"],"Ensembl":"ENSG00000205629","Gene description":"Leucine carboxyl methyltransferase 1","Uniprot":["Q9UIC8"],"Chromosome":"16","Position":"25111731-25178231","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"247.6","Oocytes":"460.5","Syncytiotrophoblasts":"205.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"460.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Liver - Vascular endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"21780551.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041559","HPA043530"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":3,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041559":null,"HPA043530":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.60e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.06e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"}},{"Gene":"LCORL","Gene synonym":["FLJ30696","MLR1"],"Ensembl":"ENSG00000178177","Gene description":"Ligand dependent nuclear receptor corepressor like","Uniprot":["Q8N3X6"],"Chromosome":"4","Position":"17841187-18021876","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028794","HPA028795","HPA060033"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA028794":null,"HPA028795":null,"HPA060033":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.96e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"}},{"Gene":"LDHAL6A","Gene synonym":["LDH6A","MGC23940"],"Ensembl":"ENSG00000166800","Gene description":"Lactate dehydrogenase A like 6A","Uniprot":["Q6ZMR3"],"Chromosome":"11","Position":"18455824-18479601","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"8.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Oocytes":"327.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Oocytes":"327.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"2.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"47487702.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LDHAL6B","Gene synonym":["LDH6B","LDHAL6","LDHL"],"Ensembl":"ENSG00000171989","Gene description":"Lactate dehydrogenase A like 6B","Uniprot":["Q9BYZ2"],"Chromosome":"15","Position":"59206843-59208588","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"99","RNA tissue specific nTPM":{"testis":"38.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"20","RNA single cell type specific nCPM":{"Early primary spermatocytes":"59.8","Late primary spermatocytes":"197.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"159","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"197.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":24,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA053962":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LDHC","Gene synonym":["CT32"],"Ensembl":"ENSG00000166796","Gene description":"Lactate dehydrogenase C","Uniprot":["P07864"],"Chromosome":"11","Position":"18412318-18452063","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"179","RNA tissue specific nTPM":{"testis":"247.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"1059.7","Late primary spermatocytes":"4060.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"85","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4060.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":15,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA045442":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LDLRAD4","Gene synonym":["C18orf1"],"Ensembl":"ENSG00000168675","Gene description":"Low density lipoprotein receptor class A domain containing 4","Uniprot":["O15165"],"Chromosome":"18","Position":"13217498-13652755","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Signal transduction inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"56.3","lymphoid tissue":"42.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"2112.5","Cone photoreceptor cells":"1705.8","Microglia":"1783.7","Prostatic glandular cells":"1046.0","Thymocytes":"1652.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2112.5","Glial cells":"1783.7","Neuronal cells":"1705.8","T-cells":"1652.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"2320.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"31.0","lymphoma":"18.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA047633":null,"HPA065246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.17e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.24e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"}},{"Gene":"LECT2","Gene synonym":["chm-II","chm2"],"Ensembl":"ENSG00000145826","Gene description":"Leukocyte cell derived chemotaxin 2","Uniprot":["O14960"],"Chromosome":"5","Position":"135922279-135954983","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Chemotaxis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"53","RNA tissue specific nTPM":{"liver":"445.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"152.1","Hepatocytes":"107.3","Late primary spermatocytes":"103.5","Late spermatids":"63.8","Retinal horizontal cells":"28.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Hepatocytes":"107.3","Spermatogenic cell types":"152.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"14.0","midbrain-derived inhibitory":"9.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"55","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"101.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"761396.7","Smooth muscle cells":"2311006.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"1210265.8","liver":"563448.7"},"Antibody":["HPA043883","HPA058246"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":26500000,"Blood concentration - Conc. blood MS [pg\/L]":"1900000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA043883":null,"HPA058246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LEF1","Gene synonym":["TCF10","TCF1ALPHA","TCF7L3"],"Ensembl":"ENSG00000138795","Gene description":"Lymphoid enhancer binding factor 1","Uniprot":["Q9UJU2"],"Chromosome":"4","Position":"108047545-108168956","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"27","RNA tissue specific nTPM":{"lymphoid tissue":"325.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"94.1","Choroid plexus epithelial cells":"264.9","Endometrial stromal cells":"73.6","Ependymal cells":"107.5","Melanocytes":"213.5","Pituicytes\/FSCs":"72.1","Renal collecting duct intercalated cells":"255.8","T-cells":"142.3","Thymocytes":"347.2","Vascular endothelial cells":"82.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"264.9","Ductal cells":"255.8","Pigment cells":"213.5","T-cells":"347.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"1148.3","pericyte":"340.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"54.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"143.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"T-cells":"143.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"151.1"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Skin - Inner root sheath cells","Spleen - T-cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"thalamus":"22.6"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4326","Protein cell type specific Intensity":{"T-cells":"432598.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA002087","CAB019405"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 39: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":23,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB019405":null,"HPA002087":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.48e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"}},{"Gene":"LEKR1","Gene synonym":["FLJ16641"],"Ensembl":"ENSG00000197980","Gene description":"Leucine, glutamate and lysine rich 1","Uniprot":["Q6ZMV7"],"Chromosome":"3","Position":"156825481-157046129","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"12.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"149.4","Ependymal cells":"297.0","Epicardial cells":"143.3","Fallopian tube ciliated cells":"145.8","Late primary spermatocytes":"226.7","Respiratory ciliated cells":"317.6","Thyrotrophs":"116.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"143.3","Ciliated cells":"317.6","Spermatogenic cell types":"226.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"146.3","ependymal cell":"318.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044039","HPA047774"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA044039":null,"HPA047774":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.38e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"}},{"Gene":"LEMD2","Gene synonym":["dJ482C21.1","LEM2","NET25"],"Ensembl":"ENSG00000161904","Gene description":"LEM domain nuclear envelope protein 2","Uniprot":["Q8NC56"],"Chromosome":"6","Position":"33771202-33789130","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"47197944.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA017340"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":12,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA017340":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.45e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.27e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"LENG1","Gene synonym":[],"Ensembl":"ENSG00000105617","Gene description":"Leukocyte receptor cluster member 1","Uniprot":["Q96BZ8"],"Chromosome":"19","Position":"54155161-54159721","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"63.9","Late primary spermatocytes":"92.9","Oocytes":"87.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"87.5","Spermatogenic cell types":"92.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"9.1","Uterine Corpus Endometrial Carcinoma (TCGA)":"15.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1706283.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"835037.7","lymphoid tissue":"346802.5"},"Antibody":["HPA043541"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":76,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA043541":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"}},{"Gene":"LEPROTL1","Gene synonym":["my047","Vps55"],"Ensembl":"ENSG00000104660","Gene description":"Leptin receptor overlapping transcript like 1","Uniprot":["O95214"],"Chromosome":"8","Position":"30095408-30177208","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"296.1","Innate lymphoid cells":"242.2","Late primary spermatocytes":"257.7","NK-cells":"268.0","T-cells":"517.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"T-cells":"517.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"162.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047911"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":68,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047911":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.28e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.94e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.40e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"LETM2","Gene synonym":["FLJ25409","SLC55A2"],"Ensembl":"ENSG00000165046","Gene description":"Leucine zipper and EF-hand containing transmembrane protein 2","Uniprot":["Q2VYF4"],"Chromosome":"8","Position":"38386207-38409527","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"13.7","testis":"22.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"50.4","Epicardial cells":"175.1","Late primary spermatocytes":"131.6","Late spermatids":"75.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"175.1","Spermatogenic cell types":"131.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"neutrophil":"21.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"21.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"6","RNA pig brain regional specific nTPM":{"cerebellum":"32.2"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA025032"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA025032":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.45e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.21e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.97e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"}},{"Gene":"LEXM","Gene synonym":["C1orf177","FLJ40201","LEM"],"Ensembl":"ENSG00000162398","Gene description":"Lymphocyte expansion molecule","Uniprot":["Q3ZCV2"],"Chromosome":"1","Position":"54806063-54842252","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"11.9","testis":"4.5","vagina":"4.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Esophageal apical cells":"246.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"246.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"5.9","leukocyte":"6.1","medium spiny neuron":"10.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"1.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"3.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"692","Protein cell type specific Intensity":{"Fallopian tube cells":"33490.6","Large ducts":"105005.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035889","HPA035890"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035889":null,"HPA035890":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LGALS8","Gene synonym":["PCTA-1"],"Ensembl":"ENSG00000116977","Gene description":"Galectin 8","Uniprot":["O00214"],"Chromosome":"1","Position":"236518000-236552981","Protein class":["Predicted intracellular proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"319.2","Kupffer cells":"186.5","Late primary spermatocytes":"269.1","Late spermatids":"345.0","Platelets":"187.8","Syncytiotrophoblasts":"235.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"345.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"119.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":22,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA012734":null,"HPA030491":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LGR6","Gene synonym":["FLJ14471"],"Ensembl":"ENSG00000133067","Gene description":"Leucine rich repeat containing G protein-coupled receptor 6","Uniprot":["Q9HBX8"],"Chromosome":"1","Position":"202193799-202319781","Protein class":["G-protein coupled receptors","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"66.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Bergmann glia":"259.5","Pituicytes\/FSCs":"631.9","Pituitary stem cells":"231.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"631.9","Stem cells":"231.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"74.0","Bergmann glia":"226.5","ependymal cell":"95.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"27.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"gdT-cell":"15.5","memory CD8 T-cell":"9.1","naive CD8 T-cell":"4.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"37","RNA blood lineage specific nTPM":{"T-cells":"15.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"6.9","colorectal cancer":"8.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA008556":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.82e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"}},{"Gene":"LHPP","Gene synonym":["HDHD2B"],"Ensembl":"ENSG00000107902","Gene description":"Phospholysine phosphohistidine inorganic pyrophosphate phosphatase","Uniprot":["Q9H008"],"Chromosome":"10","Position":"124461823-124617888","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"388.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"211.5","Late spermatids":"297.8","Tuft cells":"149.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"297.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"280000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":8,"Subcellular main location":["Nuclear speckles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA009163":null,"HPA009269":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.19e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"LHX2","Gene synonym":["hLhx2","LH-2"],"Ensembl":"ENSG00000106689","Gene description":"LIM homeobox 2","Uniprot":["P50458"],"Chromosome":"9","Position":"124001670-124033301","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"82.0","retina":"31.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"72.8","Early spermatids":"48.6","Hepatic stellate cells":"25.8","Late spermatids":"36.5","M\u00fcller glia":"290.5","Pituicytes\/FSCs":"91.5","Retinal pigment epithelial cells":"123.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"290.5","Pigment cells":"123.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"amygdala excitatory":"41.0","astrocyte":"40.2","deep-layer intratelencephalic":"54.0","hippocampal CA1-3":"33.3","hippocampal CA4":"82.9","hippocampal dentate gyrus":"21.9","LAMP5-LHX6 and Chandelier":"23.5","miscellaneous":"38.9","thalamic excitatory":"21.3","upper-layer intratelencephalic":"42.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"38.4"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"amygdala":"63.8","basal ganglia":"64.6","cerebral cortex":"89.8","hippocampal formation":"86.1","white matter":"55.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"20.9"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"}},{"Gene":"LIAS","Gene synonym":["LAS"],"Ensembl":"ENSG00000121897","Gene description":"Lipoic acid synthetase","Uniprot":["O43766"],"Chromosome":"4","Position":"39459004-39485109","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"131.2","Late primary spermatocytes":"87.6","Late spermatids":"153.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"153.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA018842":null,"HPA019076":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":48,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB080348":null,"HPA006723":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.71e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3100","Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":3,"Subcellular main location":["Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA004184":null,"HPA063840":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.86e-6"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.67e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.12e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"}},{"Gene":"LIMD2","Gene synonym":["MGC10986"],"Ensembl":"ENSG00000136490","Gene description":"LIM domain containing 2","Uniprot":["Q9BT23"],"Chromosome":"17","Position":"63695888-63701172","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"105.8","lymphoid tissue":"207.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"4.2","cDC":"4.1","Gastric chief cells":"2.2","Innate lymphoid cells":"3.2","Kupffer cells":"5.1","Megakaryocyte progenitors":"1.7","Megakaryocyte-Erythroid progenitors":"3.2","monocytes":"4.3","Neutrophils":"6.3","NK-cells":"3.4","Plasma cells":"1.9","T-cells":"2.6","Thymocytes":"2.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"4.2","dendritic cells":"4.1","Mononuclear phagocytes":"5.1","Neutrophils":"6.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"2.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"136.6","lymphoma":"246.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA062432":null,"HPA075172":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.56e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"}},{"Gene":"LIN28A","Gene synonym":["CSDD1","FLJ12457","LIN-28","LIN28","ZCCHC1"],"Ensembl":"ENSG00000131914","Gene description":"Lin-28 homolog A","Uniprot":["Q9H9Z2"],"Chromosome":"1","Position":"26410817-26429728","Protein class":["Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"4.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"111.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"48","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"111.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"1.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"85","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"334.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"testis cancer":"277.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2943","Protein cell type specific Intensity":{"Oocytes":"294253.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB020785","HPA063074","HPA068814"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Cytosol","Rods & Rings"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":250,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli","Rods & Rings"],"Antibody RRID":{"CAB020785":null,"HPA063074":null,"HPA068814":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LIN28B","Gene synonym":["CSDD2","FLJ16517"],"Ensembl":"ENSG00000187772","Gene description":"Lin-28 homolog B","Uniprot":["Q6ZN17"],"Chromosome":"6","Position":"104936616-105083332","Protein class":["Predicted intracellular proteins"],"Biological process":["RNA-mediated gene silencing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"placenta":"61.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"68.3","Corticotrophs":"69.0","Cytotrophoblasts":"241.4","Extravillous trophoblasts":"287.0","Late spermatids":"45.2","Migrating cytotrophoblasts":"218.7","Retinal ganglion cells":"119.7","Syncytiotrophoblasts":"140.7","Undifferentiated spermatogonia":"45.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"119.7","Pituitary endocrine cells":"69.0","Trophoblast cells":"287.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"24","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"21.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"22.1","testis cancer":"41.0"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":17,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036630":null,"HPA061745":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LIN54","Gene synonym":["CXCDC1","DKFZp686L1814","JC8.6","MIP120","TCX1"],"Ensembl":"ENSG00000189308","Gene description":"Lin-54 DREAM MuvB core complex component","Uniprot":["Q6MZP7"],"Chromosome":"4","Position":"82909973-83012926","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"122.1","Monocyte progenitors":"132.4","Neutrophil progenitors":"191.4","Neutrophils":"194.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"194.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":27,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056606":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.26e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.00e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.12e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - 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Fibroblasts","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"23642548.6","Neurons":"32316519.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"42112410.2"},"Antibody":["HPA071562"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":32,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA071562":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.84e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.81e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"LINGO2","Gene synonym":["LERN3","LRRN6C"],"Ensembl":"ENSG00000174482","Gene description":"Leucine rich repeat and Ig domain containing 2","Uniprot":["Q7L985"],"Chromosome":"9","Position":"27937617-29213601","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"endometrium 1":"7.3","smooth muscle":"8.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"851.0","Brain excitatory neurons":"808.5","Brain inhibitory neurons":"862.6","Decidual stromal cells":"463.6","Endometrial stromal cells":"495.0","Gonadotrophs":"439.7","Hematopoietic stem cells":"483.3","NK-cells":"406.2","Other brain neurons":"722.3","Pancreatic islet cells":"684.8","Retinal amacrine cells":"388.7","Retinal bipolar cells":"886.9","Retinal ganglion cells":"803.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"851.0","Neuronal cells":"886.9","Pancreatic islet cells":"684.8","Stromal cells":"495.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"NK-cell":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"NK-cells":"1.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"11.9"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Pancreas - Beta cells","Pituitary gland - Corticotropes","Prostate - Fibroblasts","Spleen - NK-cells (Spleen)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"6328191.6","Microglia and Neuropil":"11831931.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"15475","Protein tissue specific Intensity":{"cerebral cortex":"1547451.3"},"Antibody":["HPA016633","CAB025361"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytoplasmic bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":4,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB025361":null,"HPA016633":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LIPJ","Gene synonym":["bA425M17.2","LIPL1"],"Ensembl":"ENSG00000204022","Gene description":"Lipase family member J","Uniprot":["Q5W064"],"Chromosome":"10","Position":"88586753-88606976","Protein class":["Predicted intracellular proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"6.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"40.5","Ependymal cells":"28.1","Late primary spermatocytes":"85.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"28.1","Spermatogenic cell types":"85.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"ependymal cell":"24.8"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA048594":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LIPT1","Gene synonym":["MGC12290","MGC13378"],"Ensembl":"ENSG00000144182","Gene description":"Lipoyltransferase 1","Uniprot":["Q9Y234"],"Chromosome":"2","Position":"99154955-99163157","Protein class":["Disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1.8","Endometrial secretory cells":"1.3","Gastric progenitor cells":"1.3","Hematopoietic stem cells":"1.5","Late primary spermatocytes":"2.8","pDCs":"1.3","Smooth muscle cells":"2.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Smooth muscle cells":"2.9","Spermatogenic cell types":"2.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034802":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.37e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.85e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"}},{"Gene":"LIPT2","Gene synonym":[],"Ensembl":"ENSG00000175536","Gene description":"Lipoyl(octanoyl) transferase 2","Uniprot":["A6NK58"],"Chromosome":"11","Position":"74490519-74493724","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Ligase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"50.7","Early primary spermatocytes":"28.8","Early spermatids":"61.0","Extravillous trophoblasts":"21.7","Late primary spermatocytes":"79.6","Late spermatids":"35.4","Oocytes":"36.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"50.7","Oocytes":"36.8","Spermatogenic cell types":"79.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"6039965.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"920","Protein tissue specific Intensity":{"cerebral cortex":"91956.2"},"Antibody":["HPA040249"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040249":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.81e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"}},{"Gene":"LLCFC1","Gene synonym":["C7orf34","CTM-1"],"Ensembl":"ENSG00000165131","Gene description":"LLLL and CFNLAS motif containing 1","Uniprot":["Q96L11"],"Chromosome":"7","Position":"142939343-142940868","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Fertilization"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"39","RNA tissue specific nTPM":{"testis":"61.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"31","RNA single cell type specific nCPM":{"Early spermatids":"10.8","Late primary spermatocytes":"4.0","Late spermatids":"6.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"48","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"10.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"1.0"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LMLN","Gene synonym":["Gp63","LMNL1","Msp"],"Ensembl":"ENSG00000185621","Gene description":"Leishmanolysin like peptidase","Uniprot":["Q96KR4"],"Chromosome":"3","Position":"197960200-198043720","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"130.7","Respiratory ciliated cells":"96.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"130.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"672","Protein tissue specific Intensity":{"bone marrow":"39726.0","lymphoid tissue":"94612.7"},"Antibody":["HPA016481","HPA028844"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Focal adhesion sites","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Focal adhesion sites"],"Antibody RRID":{"HPA016481":null,"HPA028844":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - 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Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"829716019.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"960103367.9"},"Antibody":["CAB005269","HPA050524","CAB079757","CAB079954"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"860000","Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":190,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB005269":null,"CAB079757":null,"CAB079954":null,"HPA050524":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.99e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.95e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.21e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.52e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"}},{"Gene":"LMNB2","Gene synonym":["LMN2"],"Ensembl":"ENSG00000176619","Gene description":"Lamin B2","Uniprot":["Q03252"],"Chromosome":"19","Position":"2427638-2456959","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability","Neurodegeneration","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"310.2","Extravillous trophoblasts":"98.9","Late primary spermatocytes":"128.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"310.2","Trophoblast cells":"98.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB022593","HPA047863","HPA062477"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"79000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":50,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB022593":null,"HPA047863":null,"HPA062477":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.74e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.94e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.89e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.08e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"}},{"Gene":"LMNTD1","Gene synonym":["FLJ36004","IFLTD1","Pas1c1"],"Ensembl":"ENSG00000152936","Gene description":"Lamin tail domain containing 1","Uniprot":["Q8N9Z9"],"Chromosome":"12","Position":"25409307-25648579","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"16.0","testis":"14.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"317.7","Early spermatids":"225.1","Endometrial ciliated cells":"404.5","Ependymal cells":"1131.5","Epididymal efferent duct ciliated cells":"319.0","Fallopian tube ciliated cells":"399.2","Respiratory ciliated cells":"989.7","Retinal pigment epithelial cells":"336.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1131.5","Glial cells":"317.7","Pigment cells":"336.8","Spermatogenic cell types":"225.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"Bergmann glia":"334.8","ependymal cell":"1170.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"4.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Pancreas - Beta cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2275","Protein cell type specific Intensity":{"Fallopian tube cells":"227460.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038640"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA038640":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"}},{"Gene":"LMX1A","Gene synonym":["LMX1","LMX1.1"],"Ensembl":"ENSG00000162761","Gene description":"LIM homeobox transcription factor 1 alpha","Uniprot":["Q8TE12"],"Chromosome":"1","Position":"165201867-165356715","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"19.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"570.4","Corticotrophs":"711.3","Neuroendocrine cells":"250.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"570.4","Enteroendocrine cells":"250.1","Pituitary endocrine cells":"711.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"27","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"452.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.0"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"9","RNA brain regional specific nTPM":{"choroid plexus":"43.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.0","Gastric cancer":"1.0"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":5,"Subcellular main location":["Nucleoplasm","Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA030088":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LNP1","Gene synonym":["NP3"],"Ensembl":"ENSG00000206535","Gene description":"Leukemia NUP98 fusion partner 1","Uniprot":["A1A4G5"],"Chromosome":"3","Position":"100401532-100456319","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"42.7","testis":"27.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"89.0","Early spermatids":"136.7","Late primary spermatocytes":"243.0","Retinal amacrine cells":"47.3","Retinal bipolar cells":"49.3","Retinal horizontal cells":"216.4","Rod photoreceptor cells":"62.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neuronal cells":"216.4","Spermatogenic cell types":"243.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"18.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"T-cells":"1.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":8,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nuclear speckles","Cytosol"],"Antibody RRID":{"HPA047926":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"LNPK","Gene synonym":["KIAA1715","LNP","LNP1","Ul"],"Ensembl":"ENSG00000144320","Gene description":"Lunapark, ER junction formation factor","Uniprot":["Q9C0E8"],"Chromosome":"2","Position":"175923882-176002839","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"305.1","Myonuclei":"221.0","Neutrophil progenitors":"339.9","Thymic myoid cells":"197.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"339.9","Spermatogenic cell types":"305.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":24,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Nucleoplasm","Connecting piece","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA014205":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.88e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.38e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.17e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"}},{"Gene":"LNX1","Gene synonym":["LNX","MPDZ","PDZRN2"],"Ensembl":"ENSG00000072201","Gene description":"Ligand of numb-protein X 1","Uniprot":["Q8TBB1"],"Chromosome":"4","Position":"53459301-53701405","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"252.4","Early spermatids":"246.9","Endometrial ciliated cells":"291.1","Endometrial glandular cells":"998.6","Endometrial luminal cells":"500.4","Esophageal apical cells":"652.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"652.3","Glandular cells":"998.6","Luminal cells":"500.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"5213","Protein cell type specific Intensity":{"Collecting ducts":"336710.7","Distal tubules":"430011.4","Large ducts":"985196.6","Neurons":"470981.0","Pancreas epithelial cells":"383622.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"258","Protein tissue specific Intensity":{"salivary gland":"25809.2"},"Antibody":["HPA002235","HPA071091"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cell Junctions","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":380,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA002235":null,"HPA071091":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.08e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.89e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"}},{"Gene":"LOXL1","Gene synonym":["LOL","LOXL"],"Ensembl":"ENSG00000129038","Gene description":"Lysyl oxidase like 1","Uniprot":["Q08397"],"Chromosome":"15","Position":"73925989-73952137","Protein class":["Disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Glaucoma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"67.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"164.7","Extravillous trophoblasts":"245.8","Fibroblasts":"60.4","Hepatic stellate cells":"213.0","Podocytes":"58.8","Retinal pigment epithelial cells":"85.3","Smooth muscle cells":"53.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"164.7","Stellate cells":"213.0","Trophoblast cells":"245.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"120.7","fibroblast":"31.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"26.2"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"3.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"34","RNA blood lineage specific nTPM":{"T-cells":"3.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"89.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Adrenal gland - Fibroblasts","Liver - Hepatic stellate cells","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"55776221.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"63106229.6"},"Antibody":["HPA042111","HPA063583"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Enzyme","CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":2,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA042111":null,"HPA063583":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.76e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.57e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"}},{"Gene":"LPAR6","Gene synonym":["P2RY5","P2Y5"],"Ensembl":"ENSG00000139679","Gene description":"Lysophosphatidic acid receptor 6","Uniprot":["P43657"],"Chromosome":"13","Position":"48389567-48444704","Protein class":["Disease related genes","G-protein coupled receptors","Human disease related genes","Potential drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Disease variant","Hypotrichosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"313.3","Early spermatids":"442.5","Epicardial cells":"343.4","Esophageal apical cells":"319.1","Late spermatids":"412.9","Macrophages":"227.8","Microglia":"893.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"893.3","Spermatogenic cell types":"442.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1088.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA028934":null,"HPA076273":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.44e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":18,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"}},{"Gene":"LPO","Gene synonym":["SPO"],"Ensembl":"ENSG00000167419","Gene description":"Lactoperoxidase","Uniprot":["P22079"],"Chromosome":"17","Position":"58218548-58268518","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Hydrogen peroxide"],"Molecular function":["Antimicrobial","Oxidoreductase","Peroxidase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"841","RNA tissue specific nTPM":{"salivary gland":"967.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"289.2","Lacrimal acinar cells":"184.8","Salivary acinar cells":"1162.3","Salivary myoepithelial cells":"330.1","Submucosal glandular cells":"66.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"1162.3","Secretory cells":"289.2","Secretory gland support":"330.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"21.8"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"midbrain":"5.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"1.4"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Skin - Sebaceous gland cells","Spleen - Neutrophils_1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"58011","Protein cell type specific Intensity":{"Large ducts":"5801119.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"365632952.9"},"Antibody":["HPA028688"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to digestive system","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028688":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRFN2","Gene synonym":["FIGLER2","KIAA1246","SALM1"],"Ensembl":"ENSG00000156564","Gene description":"Leucine rich repeat and fibronectin type III domain containing 2","Uniprot":["Q9ULH4"],"Chromosome":"6","Position":"40391591-40587364","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"6.3","retina":"2.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"865.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Neuronal cells":"865.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"2.1","Neuroblastoma":"4.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA076660":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRFN4","Gene synonym":["FIGLER6","MGC3103","SALM3."],"Ensembl":"ENSG00000173621","Gene description":"Leucine rich repeat and fibronectin type III domain containing 4","Uniprot":["Q6PJG9"],"Chromosome":"11","Position":"66856647-66860475","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"35.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"25.3","Late spermatids":"45.1","Podocytes":"26.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"45.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA077570":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029505":null,"HPA029506":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"}},{"Gene":"LRIT1","Gene synonym":["DKFZP434K091","FIGLER9","LRRC21","PAL"],"Ensembl":"ENSG00000148602","Gene description":"Leucine rich repeat, Ig-like and transmembrane domains 1","Uniprot":["Q9P2V4"],"Chromosome":"10","Position":"84231520-84241546","Protein class":["Predicted membrane proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"retina":"23.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"25.3","Late primary spermatocytes":"44.3","Late spermatids":"53.0","Retinal bipolar cells":"14.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"14.0","Spermatogenic cell types":"53.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"1.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":null,"Antibody RRID":{"HPA014296":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRIT3","Gene synonym":["CSNB1F","FIGLER4","FLJ44691"],"Ensembl":"ENSG00000183423","Gene description":"Leucine rich repeat, Ig-like and transmembrane domains 3","Uniprot":["Q3SXY7"],"Chromosome":"4","Position":"109848107-109872315","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Congenital stationary night blindness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"retina":"16.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"8.3","Ependymal cells":"4.5","M\u00fcller glia":"17.7","Retinal pigment epithelial cells":"17.1","Rod photoreceptor cells":"7.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"4.5","Glial cells":"17.7","Neuronal cells":"8.3","Pigment cells":"17.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"1.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRP1B","Gene synonym":["LRP-DIT","LRPDIT"],"Ensembl":"ENSG00000168702","Gene description":"LDL receptor related protein 1B","Uniprot":["Q9NZR2"],"Chromosome":"2","Position":"140231423-142131016","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Endocytosis"],"Molecular function":["Receptor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"9.4","thyroid gland":"5.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"4292.7","Bergmann glia":"4281.2","Brain excitatory neurons":"3314.8","Brain inhibitory neurons":"2318.8","Ependymal cells":"1416.4","Lactotrophs":"3235.0","Oligodendrocyte progenitor cells":"7072.9","Oligodendrocytes":"1743.4","Other brain neurons":"3835.1","Pituicytes\/FSCs":"2918.7","Pituitary stem cells":"2020.2","Retinal ganglion cells":"2078.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"7072.9","Neuronal cells":"3835.1","Pituitary endocrine cells":"3235.0","Stem cells":"2020.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"6.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"3.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3044397.4","Large ducts":"6737275.5","Microglia and Neuropil":"3239370.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"244963","Protein tissue specific Intensity":{"cerebral cortex":"24496300.9"},"Antibody":["HPA069094","HPA074788"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"98000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA069094":null,"HPA074788":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRP2BP","Gene synonym":["DKFZp761O0113"],"Ensembl":"ENSG00000109771","Gene description":"LRP2 binding protein","Uniprot":["Q9P2M1"],"Chromosome":"4","Position":"185363872-185395924","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pituitary gland":"16.4","retina":"26.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"103.8","Cone photoreceptor cells":"101.4","Ependymal cells":"248.6","Epicardial cells":"204.7","Retinal bipolar cells":"102.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"204.7","Ciliated cells":"248.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"274.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Lung - Alveolar cells type 2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3301","Protein cell type specific Intensity":{"Fallopian tube cells":"330133.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"894","Protein tissue specific Intensity":{"fallopian tube":"89391.3"},"Antibody":["HPA036664","HPA036665"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":18,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA036664":null,"HPA036665":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.43e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.62e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"}},{"Gene":"LRR1","Gene synonym":["LRR-1","MGC20689","PPIL5"],"Ensembl":"ENSG00000165501","Gene description":"Leucine rich repeat protein 1","Uniprot":["Q96L50"],"Chromosome":"14","Position":"49598761-49614672","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"27.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"103.9","Erythrocyte progenitors":"68.7","Late primary spermatocytes":"345.6","Late spermatids":"52.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"345.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"9.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"241","Protein tissue specific Intensity":{"cerebral cortex":"24108.9"},"Antibody":["HPA065703","HPA069364"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":17,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA065703":null,"HPA069364":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.29e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.87e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"LRRC1","Gene synonym":["dJ523E19.1","FLJ10775","FLJ11834","LANO"],"Ensembl":"ENSG00000137269","Gene description":"Leucine rich repeat containing 1","Uniprot":["Q9BTT6"],"Chromosome":"6","Position":"53794497-53924125","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"244.5","Endometrial glandular cells":"237.1","Lymphatic endothelial cells":"246.2","Pituicytes\/FSCs":"254.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"289.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":20,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA031603":null,"HPA031604":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.79e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.93e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.77e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.45e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"}},{"Gene":"LRRC10B","Gene synonym":[],"Ensembl":"ENSG00000204950","Gene description":"Leucine rich repeat containing 10B","Uniprot":["A6NIK2"],"Chromosome":"11","Position":"61508749-61511018","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"59.2","fallopian tube":"27.0","pituitary gland":"31.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"56.9","Ependymal cells":"32.4","Epididymal efferent duct ciliated cells":"49.5","Fallopian tube ciliated cells":"179.1","Pancreatic islet cells":"32.8","Respiratory ciliated cells":"225.3","Vascular smooth muscle cells":"38.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"225.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"37.9","medium spiny neuron":"20.7","vascular associated smooth muscle cell":"24.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"7.4"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"basal ganglia":"90.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"4.0","Sarcoma":"3.6"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA047619":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039256":null,"HPA076699":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039630":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":null,"Antibody RRID":{"HPA037766":null,"HPA057533":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.72e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"}},{"Gene":"LRRC27","Gene synonym":["KIAA1674"],"Ensembl":"ENSG00000148814","Gene description":"Leucine rich repeat containing 27","Uniprot":["Q9C0I9"],"Chromosome":"10","Position":"132332154-132381508","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"72.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"540.9","Late primary spermatocytes":"454.7","Late spermatids":"1552.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1552.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"129.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Mitochondria"],"Antibody RRID":{"HPA039378":null,"HPA040784":null,"HPA066130":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.76e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.95e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Primary cilium","Basal body"],"Antibody RRID":{"HPA035747":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA055237":null,"HPA058479":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRC37A3","Gene synonym":["FLJ34306","KIAA0563"],"Ensembl":"ENSG00000176809","Gene description":"Leucine rich repeat containing 37 member A3","Uniprot":["O60309"],"Chromosome":"17","Position":"64854130-64919480","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"27.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"143.1","Ependymal cells":"110.1","Loop of henle epithelial cells":"155.1","Papillary tip epithelial cells":"142.8","Proximal tubule cells":"141.5","Renal collecting duct intercalated cells":"120.3","Renal collecting duct principal cells":"184.7","Renal connecting tubule cells":"125.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"184.7","Renal nephron cells":"155.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"2.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA042121":null,"HPA043056":null,"HPA045090":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"}},{"Gene":"LRRC37B","Gene synonym":[],"Ensembl":"ENSG00000185158","Gene description":"Leucine rich repeat containing 37B","Uniprot":["Q96QE4"],"Chromosome":"17","Position":"32007383-32053504","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"110.0","Gonadotrophs":"80.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"110.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"2.0","NK-cells":"5.2","T-cells":"3.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA015135":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.08e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"}},{"Gene":"LRRC39","Gene synonym":["MGC14816","myomasp"],"Ensembl":"ENSG00000122477","Gene description":"Leucine rich repeat containing 39","Uniprot":["Q96DD0"],"Chromosome":"1","Position":"100148448-100178273","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Muscle protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"100.1","retina":"109.2","skeletal muscle":"403.8","tongue":"161.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"150.0","Cone photoreceptor cells":"302.2","Hofbauer cells":"246.8","Late primary spermatocytes":"281.5","Myonuclei":"784.4","Retinal amacrine cells":"90.3","Retinal horizontal cells":"138.2","Rod photoreceptor cells":"356.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"246.8","Myocytes":"784.4","Neuronal cells":"356.6","Spermatogenic cell types":"281.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"119.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA077159":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"}},{"Gene":"LRRC3B","Gene synonym":["LRP15"],"Ensembl":"ENSG00000179796","Gene description":"Leucine rich repeat containing 3B","Uniprot":["Q96PB8"],"Chromosome":"3","Position":"26622772-26717537","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"23.8","skeletal muscle":"8.8","testis":"6.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"443.4","Bergmann glia":"75.5","Brain excitatory neurons":"140.0","Brain inhibitory neurons":"61.5","Early spermatids":"69.0","Ependymal cells":"163.0","Late primary spermatocytes":"133.0","Medullary thymic epithelial cells":"112.8","Oligodendrocyte progenitor cells":"52.6","Other brain neurons":"97.3","Pituitary stem cells":"90.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"163.0","Glial cells":"443.4","Neuronal cells":"140.0","Secretory gland support":"112.8","Spermatogenic cell types":"133.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"382.8","upper rhombic lip":"346.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"8.4","Ovary Serous Cystadenocarcinoma (TCGA)":"2.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"2.4"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015568":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-1"}},{"Gene":"LRRC4","Gene synonym":["NAG14"],"Ensembl":"ENSG00000128594","Gene description":"Leucine rich repeat containing 4","Uniprot":["Q9HBW1"],"Chromosome":"7","Position":"128027071-128032107","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"28.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hofbauer cells":"46.7","Kupffer cells":"31.8","Neutrophils":"72.2","Ocular epithelial cells":"47.6","Respiratory ciliated cells":"74.3","Retinal horizontal cells":"32.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"47.6","Ciliated cells":"74.3","Mononuclear phagocytes":"46.7","Neutrophils":"72.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"neutrophil":"13.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"20","RNA blood lineage specific nTPM":{"granulocytes":"13.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"8.2"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"730000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":4,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA051100":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.88e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.88e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.17e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA039425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"}},{"Gene":"LRRC46","Gene synonym":["MGC16309"],"Ensembl":"ENSG00000141294","Gene description":"Leucine rich repeat containing 46","Uniprot":["Q96FV0"],"Chromosome":"17","Position":"47831634-47837719","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"73.8","testis":"49.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"126.8","Endometrial ciliated cells":"171.1","Ependymal cells":"87.6","Epididymal efferent duct ciliated cells":"183.8","Fallopian tube ciliated cells":"392.7","Late primary spermatocytes":"305.5","Late spermatids":"85.5","Respiratory ciliated cells":"318.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"42","RNA single cell type group specific nCPM":{"Ciliated cells":"392.7","Spermatogenic cell types":"305.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"ependymal cell":"107.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"14.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nuclear bodies","Primary cilium","Basal body"],"Antibody RRID":{"HPA074893":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.86e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"LRRC49","Gene synonym":["CSTPP2","FLJ20156","PGs4"],"Ensembl":"ENSG00000137821","Gene description":"Leucine rich repeat containing 49","Uniprot":["Q8IUZ0"],"Chromosome":"15","Position":"70853239-71053658","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"28.0","heart muscle":"52.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"187.2","Lactotrophs":"236.1","Late spermatids":"175.8","Retinal bipolar cells":"248.6","Somatotrophs":"213.0","Thyrotrophs":"298.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"187.2","Neuronal cells":"248.6","Pituitary endocrine cells":"298.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA015596":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.11e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA039949":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRC53","Gene synonym":[],"Ensembl":"ENSG00000162621","Gene description":"Leucine rich repeat containing 53","Uniprot":["A6NM62"],"Chromosome":"1","Position":"74469376-74512611","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"60","RNA single cell type specific nCPM":{"Cardiomyocytes":"771.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"60","RNA single cell type group specific nCPM":{"Myocytes":"771.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"amygdala excitatory":"5.9","deep-layer intratelencephalic":"5.4","hippocampal dentate gyrus":"20.7","upper-layer intratelencephalic":"16.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"1.2"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"LRRC59","Gene synonym":["FLJ21675","PRO1855"],"Ensembl":"ENSG00000108829","Gene description":"Leucine rich repeat containing 59","Uniprot":["Q96AG4"],"Chromosome":"17","Position":"50375059-50397523","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"356.4","Syncytiotrophoblasts":"293.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"356.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4000000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":122,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA030827":null,"HPA030829":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA039318":null,"HPA039763":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA046337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRC7","Gene synonym":["densin-180","KIAA1365"],"Ensembl":"ENSG00000033122","Gene description":"Leucine rich repeat containing 7","Uniprot":[],"Chromosome":"1","Position":"69567922-70151945","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"7.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"415.4","Brain excitatory neurons":"1307.9","Brain inhibitory neurons":"1786.4","Oligodendrocyte progenitor cells":"1214.3","Oligodendrocytes":"442.2","Other brain neurons":"760.9","Retinal bipolar cells":"762.2","Retinal ganglion cells":"312.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Glial cells":"1214.3","Neuronal cells":"1786.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"2.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":8,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm","Centrosome"],"Antibody RRID":{"HPA005625":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":19,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA046698":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035094":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRC74B","Gene synonym":[],"Ensembl":"ENSG00000187905","Gene description":"Leucine rich repeat containing 74B","Uniprot":["Q6ZQY2"],"Chromosome":"22","Position":"21045946-21064168","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"1.6","fallopian tube":"2.5","testis":"1.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"104.1","Endometrial ciliated cells":"39.5","Ependymal cells":"333.2","Epididymal efferent duct ciliated cells":"49.5","Fallopian tube ciliated cells":"52.5","Respiratory ciliated cells":"61.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"38","RNA single cell type group specific nCPM":{"Ciliated cells":"333.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"22","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"79.3","ependymal cell":"308.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049947":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRC8B","Gene synonym":["KIAA0231","TA-LRRP"],"Ensembl":"ENSG00000197147","Gene description":"Leucine rich repeat containing 8 VRAC subunit B","Uniprot":["Q6P9F7"],"Chromosome":"1","Position":"89524829-89597861","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"20.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"196.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA017950":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.48e-4"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.09e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"}},{"Gene":"LRRC8C","Gene synonym":["AD158"],"Ensembl":"ENSG00000171488","Gene description":"Leucine rich repeat containing 8 VRAC subunit C","Uniprot":["Q8TDW0"],"Chromosome":"1","Position":"89633072-89769903","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel"],"Disease involvement":["Disease variant","Dwarfism","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"4.9","Late spermatids":"9.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"9.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"1.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"9.0","monocytes":"6.6","T-cells":"11.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":5,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA029347":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"}},{"Gene":"LRRC9","Gene synonym":["FLJ46156"],"Ensembl":"ENSG00000131951","Gene description":"Leucine rich repeat containing 9","Uniprot":["Q6ZRR7"],"Chromosome":"14","Position":"59919713-60066817","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"2.5","testis":"5.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"111.1","Choroid plexus epithelial cells":"384.7","Early spermatids":"251.2","Ependymal cells":"885.1","Epicardial cells":"97.8","Epididymal efferent duct ciliated cells":"195.6","Late spermatids":"139.1","Prostatic glandular cells":"323.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"885.1","Glandular cells":"323.9","Spermatogenic cell types":"251.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"350.5","ependymal cell":"922.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"1.4","Prostate Adenocarcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"214960410.4"},"Antibody":["HPA040965","HPA041381","HPA077675"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Plasma membrane","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":["Nucleoplasm","Nuclear bodies"],"Antibody RRID":{"HPA040965":null,"HPA041381":null,"HPA077675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRCC1","Gene synonym":["CLERC","KIAA1764","VFL1"],"Ensembl":"ENSG00000133739","Gene description":"Leucine rich repeat and coiled-coil centrosomal protein 1","Uniprot":["Q9C099"],"Chromosome":"8","Position":"85107215-85146080","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"31.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"109.5","Early spermatids":"154.9","Erythrocyte progenitors":"96.4","Late primary spermatocytes":"389.0","Late spermatids":"246.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"389.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Vesicles","Primary cilium","Primary cilium tip","Cytosol"],"Antibody RRID":{"HPA012893":null,"HPA075880":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"}},{"Gene":"LRRD1","Gene synonym":["IMAGE:4798971"],"Ensembl":"ENSG00000240720","Gene description":"Leucine rich repeats and death domain containing 1","Uniprot":["A4D1F6"],"Chromosome":"7","Position":"92141643-92179531","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"29","RNA tissue specific nTPM":{"testis":"13.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"1.6","Early spermatids":"4.0","Late spermatids":"11.9","Loop of henle epithelial cells":"1.6","Papillary tip epithelial cells":"1.1","Podocytes":"1.5","Proximal tubule cells":"1.6","Renal collecting duct intercalated cells":"2.2","Renal collecting duct principal cells":"1.6","Renal connecting tubule cells":"1.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"11.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA079440"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA079440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - 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Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"11154527.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035956","HPA042023"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Actin filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"250000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":13,"Subcellular main location":["Plasma membrane","Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA035956":null,"HPA042023":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.04e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.11e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"}},{"Gene":"LRRIQ1","Gene synonym":["FLJ12303","KIAA1801"],"Ensembl":"ENSG00000133640","Gene description":"Leucine rich repeats and IQ motif containing 1","Uniprot":["Q96JM4"],"Chromosome":"12","Position":"85036314-85264457","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"13.3","fallopian tube":"12.9","testis":"14.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"611.0","Early spermatids":"416.1","Endometrial ciliated cells":"671.9","Ependymal cells":"1460.9","Epididymal efferent duct ciliated cells":"858.7","Fallopian tube ciliated cells":"820.8","Late primary spermatocytes":"607.5","Late spermatids":"357.4","Respiratory ciliated cells":"1857.0","Respiratory deuterosomal cells":"300.6","Rod photoreceptor cells":"303.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"1857.0","Spermatogenic cell types":"607.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"556.5","ependymal cell":"1608.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Enteric glia cells","Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2065","Protein cell type specific Intensity":{"Fallopian tube cells":"206468.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046162"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046162":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-3"}},{"Gene":"LRRIQ3","Gene synonym":["LRRC44","MGC22773"],"Ensembl":"ENSG00000162620","Gene description":"Leucine rich repeats and IQ motif containing 3","Uniprot":["A6PVS8"],"Chromosome":"1","Position":"74026015-74198187","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"19.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"129.2","Early primary spermatocytes":"122.3","Early spermatids":"194.8","Ependymal cells":"63.8","Late primary spermatocytes":"474.9","Late spermatids":"123.4","Respiratory ciliated cells":"62.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adipocytes":"129.2","Spermatogenic cell types":"474.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"67.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"1302139.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030799"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA030799":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"}},{"Gene":"LRRIQ4","Gene synonym":["LRRC64"],"Ensembl":"ENSG00000188306","Gene description":"Leucine rich repeats and IQ motif containing 4","Uniprot":["A6NIV6"],"Chromosome":"3","Position":"169812870-169837773","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"2.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"67.2","Late spermatids":"40.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"67.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"7.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"1.2"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036271","HPA036706"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA036271":null,"HPA036706":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRRK1","Gene synonym":["FLJ23119","KIAA1790","RIPK6","ROCO1"],"Ensembl":"ENSG00000154237","Gene description":"Leucine rich repeat kinase 1","Uniprot":["Q38SD2"],"Chromosome":"15","Position":"100919327-101078257","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"177.4","Leydig cells":"199.5","Microglia":"643.8","pDCs":"212.5","Plasma cells":"257.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"643.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"745.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":18,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA010537":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"}},{"Gene":"LRRTM3","Gene synonym":[],"Ensembl":"ENSG00000198739","Gene description":"Leucine rich repeat transmembrane neuronal 3","Uniprot":["Q86VH5"],"Chromosome":"10","Position":"66926036-67101551","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"2.4","brain":"10.4","pituitary gland":"2.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Cardiomyocytes":"7362.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Myocytes":"7362.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"1.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Enteric glia cells","Pancreas - Beta cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2561896.9","B-cells":"2289238.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"10099","Protein tissue specific Intensity":{"cerebral cortex":"1009917.9"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LRWD1","Gene synonym":["CENP-33","DKFZp434K1815","ORCA"],"Ensembl":"ENSG00000161036","Gene description":"Leucine rich repeats and WD repeat domain containing 1","Uniprot":["Q9UFC0"],"Chromosome":"7","Position":"102464956-102473168","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA replication"],"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"272.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"897.5","Late primary spermatocytes":"1786.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1786.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"29.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":16,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA021320":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA051934":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.58e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.24e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.24e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"}},{"Gene":"LSM3","Gene synonym":["SMX4","USS2","YLR438C"],"Ensembl":"ENSG00000170860","Gene description":"LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated","Uniprot":["P62310"],"Chromosome":"3","Position":"14178817-14201122","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"459.5","Esophageal apical cells":"457.4","Esophageal basal cells":"525.9","Extravillous trophoblasts":"491.6","Late primary spermatocytes":"526.9","Migrating cytotrophoblasts":"469.7","Oocytes":"497.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"31260075.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044966"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"96000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":78,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA044966":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.06e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"}},{"Gene":"LSM4","Gene synonym":["YER112W"],"Ensembl":"ENSG00000130520","Gene description":"LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated","Uniprot":["Q9Y4Z0"],"Chromosome":"19","Position":"18306236-18323112","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"424.9","Esophageal basal cells":"389.5","Extravillous trophoblasts":"556.3","Late spermatids":"1064.5","Migrating cytotrophoblasts":"454.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1064.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040932"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":102,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA040932":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.52e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.11e-11"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.49e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"}},{"Gene":"LURAP1","Gene synonym":["C1orf190","FLJ25163","LRAP35a"],"Ensembl":"ENSG00000171357","Gene description":"Leucine rich adaptor protein 1","Uniprot":["Q96LR2"],"Chromosome":"1","Position":"46203334-46221256","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"132.4","Endometrial luminal cells":"169.2","Late primary spermatocytes":"135.2","Late spermatids":"509.9","Renal connecting tubule cells":"59.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Luminal cells":"169.2","Spermatogenic cell types":"509.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"181328.0","Microglia and Neuropil":"384613.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"18888","Protein tissue specific Intensity":{"cerebral cortex":"2690890.1","ovary":"1086807.8"},"Antibody":["HPA030060","HPA030061"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":28,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA030060":null,"HPA030061":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.54e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"}},{"Gene":"LUZP2","Gene synonym":[],"Ensembl":"ENSG00000187398","Gene description":"Leucine zipper protein 2","Uniprot":["Q86TE4"],"Chromosome":"11","Position":"24496970-25082638","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"adrenal gland":"6.1","brain":"16.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Oligodendrocyte progenitor cells":"2829.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"2829.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"2215.3","oligodendrocyte precursor cell":"3348.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"9.6","Prostate Adenocarcinoma (TCGA)":"10.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"5.7"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Colon - Colon enteroendocrine cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039007","HPA046161"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":"Secreted in brain","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA039007":null,"HPA046161":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LVRN","Gene synonym":["APQ","AQPEP","FLJ90650","TAQPEP"],"Ensembl":"ENSG00000172901","Gene description":"Laeverin","Uniprot":["Q6Q4G3"],"Chromosome":"5","Position":"115962454-116027619","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"adipose tissue":"10.3","placenta":"20.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"351.7","Corticotrophs":"60.4","Early spermatids":"47.7","Extravillous trophoblasts":"102.1","Fibro-adipogenic progenitors":"79.3","Late spermatids":"123.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"351.7","Fibro-adipogenic progenitors":"79.3","Spermatogenic cell types":"123.3","Trophoblast cells":"102.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"1.0","Gallbladder cancer":"1.9","thyroid cancer":"1.0"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Minor Salivary Gland - Adipocytes (Minor salivary gland)","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Smooth muscle cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"8","RNA pig brain regional specific nTPM":{"spinal cord":"3.3"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"103","Protein cell type specific Intensity":{"Pancreatic islets":"10293.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"282","Protein tissue specific Intensity":{"intestine":"20751.8","skin":"35697.1"},"Antibody":["HPA053254"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3800","Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053254":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.62e-7"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LY6G5C","Gene synonym":["C6orf20","G5c","NG33"],"Ensembl":"ENSG00000204428","Gene description":"Lymphocyte antigen 6 family member G5C","Uniprot":["Q5SRR4"],"Chromosome":"6","Position":"31676684-31684040","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"2.0","Brain excitatory neurons":"2.4","Brain inhibitory neurons":"5.4","Differentiating spermatogonia":"2.0","Ependymal cells":"2.5","Gastric chief cells":"2.2","Late primary spermatocytes":"2.2","Oligodendrocyte progenitor cells":"2.6","Parietal cells":"5.3","Platelets":"8.5","Respiratory ionocytes":"2.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"5.3","Neuronal cells":"5.4","Platelets":"8.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038690":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LY6G6D","Gene synonym":["C6orf23","G6D","Ly6-D","MEGT1","NG25"],"Ensembl":"ENSG00000244355","Gene description":"Lymphocyte antigen 6 family member G6D","Uniprot":["O95868"],"Chromosome":"6","Position":"31715348-31717919","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skin 1":"33.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Platelets":"2.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Platelets":"2.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"29","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"16.4","Rectum Adenocarcinoma (TCGA)":"25.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"16","RNA cell line specific nTPM":{"colorectal cancer":"46.5"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 9: Skin - Hair follicle development","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054412":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LY6G6F","Gene synonym":["C6orf21","G6f","LY6G6D","NG32"],"Ensembl":"ENSG00000204424","Gene description":"Lymphocyte antigen 6 family member G6F","Uniprot":["Q5SQ64"],"Chromosome":"6","Position":"31706866-31710679","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"3.6","lymphoid tissue":"1.2","skin 1":"1.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Platelets":"518.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Platelets":"518.8"},"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"neutrophil":"2.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"2.6"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"1.7","Leukemia":"1.4"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"760000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA008053":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LYAR","Gene synonym":["ZC2HC2","ZLYAR"],"Ensembl":"ENSG00000145220","Gene description":"Ly1 antibody reactive","Uniprot":["Q9NX58"],"Chromosome":"4","Position":"4267701-4290154","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Immunity","Innate immunity","rRNA processing","Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"95.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Late primary spermatocytes":"1609.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1609.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"33.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":172,"Subcellular main location":["Nucleoli rim"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA035880":null,"HPA035881":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.83e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.67e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.45e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.97e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.49e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-3"}},{"Gene":"LYG2","Gene synonym":["LYGA2","LYGH"],"Ensembl":"ENSG00000185674","Gene description":"Lysozyme g2","Uniprot":["Q86SG7"],"Chromosome":"2","Position":"99242246-99255666","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Glycosidase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"retina":"3.2","skin 1":"7.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"14.7","Cardiomyocytes":"37.6","Epicardial cells":"15.9","Myonuclei":"16.5","Retinal bipolar cells":"13.8","Retinal ganglion cells":"34.8","Retinal horizontal cells":"24.0","Rod photoreceptor cells":"22.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"37.6","Neuronal cells":"34.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"2.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039179"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039179":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"}},{"Gene":"LYPD4","Gene synonym":["MGC42718"],"Ensembl":"ENSG00000273111","Gene description":"LY6\/PLAUR domain containing 4","Uniprot":["Q6UWN0"],"Chromosome":"19","Position":"41837074-41844697","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"314","RNA tissue specific nTPM":{"testis":"99.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"622.8","Late spermatids":"1505.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"282","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1505.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LYPD6B","Gene synonym":["CT116","LYPD7"],"Ensembl":"ENSG00000150556","Gene description":"LY6\/PLAUR domain containing 6B","Uniprot":["Q8NI32"],"Chromosome":"2","Position":"149038107-149215262","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skin 1":"91.9","stomach 1":"39.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"189.3","Early spermatids":"275.7","Foveolar cells":"665.4","Late primary spermatocytes":"176.9","Papillary tip epithelial cells":"369.0","Prostatic club cells":"493.6","Prostatic hillock cells":"283.4","Renal collecting duct principal cells":"302.2","Respiratory deuterosomal cells":"203.2","Respiratory ionocytes":"167.6","Respiratory secretory cells":"189.7","Sertoli cells":"163.5","Urothelial cells":"326.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"326.1","Gastric glandular cells":"665.4","Glandular cells":"493.6","Renal nephron cells":"369.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"216.9","midbrain-derived inhibitory":"342.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"65.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"13.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"13.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Skin - Keratinocyte (other)","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049239"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 68: Foveolar cells - Mucosal defense","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049239":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"LYPLA1","Gene synonym":["APT-1","LPL1"],"Ensembl":"ENSG00000120992","Gene description":"Lysophospholipase 1","Uniprot":["O75608"],"Chromosome":"8","Position":"54046367-54102017","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Fatty acid metabolism","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"974.8","Esophageal apical cells":"886.5","Extravillous trophoblasts":"482.5","Late spermatids":"1093.6","Syncytiotrophoblasts":"543.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"886.5","Spermatogenic cell types":"1093.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"280000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":2,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA050941":null,"HPA063151":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.38e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.24e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.32e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"LYRM1","Gene synonym":["A211C6.1"],"Ensembl":"ENSG00000102897","Gene description":"LYR motif containing 1","Uniprot":["O43325"],"Chromosome":"16","Position":"20899868-20925006","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"204.2","Late primary spermatocytes":"198.8","Late spermatids":"779.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"779.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"155.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"155.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"7090996.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2525166.4","fallopian tube":"873473.6","heart muscle":"3216439.2","liver":"1790851.2"},"Antibody":["HPA059840"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Midbody"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Midbody"],"Antibody RRID":{"HPA059840":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-5"}},{"Gene":"LYRM4","Gene synonym":["C6orf149","CGI-203","ISD11"],"Ensembl":"ENSG00000214113","Gene description":"LYR motif containing 4","Uniprot":["Q9HD34"],"Chromosome":"6","Position":"5103629-5260950","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":19,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA030362":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.39e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.71e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA050053":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"}},{"Gene":"LYSMD2","Gene synonym":["MGC35274"],"Ensembl":"ENSG00000140280","Gene description":"LysM domain containing 2","Uniprot":["Q8IV50"],"Chromosome":"15","Position":"51723011-51751585","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"173.8","Late spermatids":"133.6","Neuroendocrine cells":"80.1","pDCs":"97.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"173.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA040460":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.27e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"}},{"Gene":"LYZL1","Gene synonym":["LYC2","MGC33408"],"Ensembl":"ENSG00000120563","Gene description":"Lysozyme like 1","Uniprot":["Q6UWQ5"],"Chromosome":"10","Position":"29289061-29318328","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Glycosidase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"438","RNA tissue specific nTPM":{"testis":"48.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"137","RNA single cell type specific nCPM":{"Early spermatids":"586.0","Late primary spermatocytes":"427.3","Late spermatids":"263.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"188","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"586.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"Bergmann glia":"1.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA025734":null,"HPA053073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"LZIC","Gene synonym":["MGC15436"],"Ensembl":"ENSG00000162441","Gene description":"Leucine zipper and CTNNBIP1 domain containing","Uniprot":["Q8WZA0"],"Chromosome":"1","Position":"9922113-9943407","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"176.9","Early spermatids":"285.6","Late primary spermatocytes":"345.7","Megakaryocytes":"204.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"345.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"310000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA028184":null,"HPA058614":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"}},{"Gene":"LZTFL1","Gene synonym":["BBS17"],"Ensembl":"ENSG00000163818","Gene description":"Leucine zipper transcription factor like 1","Uniprot":["Q9NQ48"],"Chromosome":"3","Position":"45823316-45916042","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct ciliated cells":"97.8","Fallopian tube ciliated cells":"106.1","Late primary spermatocytes":"355.8","Respiratory ciliated cells":"121.2","Thymocytes":"141.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"355.8","T-cells":"141.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":31,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Primary cilium","Primary cilium transition zone"],"Antibody RRID":{"HPA043466":null,"HPA048447":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"}},{"Gene":"MACO1","Gene synonym":["FLJ10747","TMEM57"],"Ensembl":"ENSG00000204178","Gene description":"Macoilin 1","Uniprot":["Q8N5G2"],"Chromosome":"1","Position":"25430858-25500209","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"548.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"548.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"4452770.3"},"Antibody":["HPA019680"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":30,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019680":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.57e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.18e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.67e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"}},{"Gene":"MAD1L1","Gene synonym":["HsMAD1","MAD1","PIG9","TP53I9","TXBP181"],"Ensembl":"ENSG00000002822","Gene description":"Mitotic arrest deficient 1 like 1","Uniprot":["Q9Y6D9"],"Chromosome":"7","Position":"1815793-2233243","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"62.5","Distal convoluted tubule cells":"47.9","Ependymal cells":"37.5","Late spermatids":"133.8","Loop of henle epithelial cells":"83.0","Microglia":"84.3","Oligodendrocytes":"54.7","Papillary tip epithelial cells":"62.6","Podocytes":"83.9","Proximal tubule cells":"63.5","Renal collecting duct intercalated cells":"68.7","Renal collecting duct principal cells":"72.5","Renal connecting tubule cells":"63.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"62.5","Ductal cells":"72.5","Glial cells":"84.3","Renal nephron cells":"83.9","Spermatogenic cell types":"133.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"115.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"10009603.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"6287773.5"},"Antibody":["HPA003635","CAB015338"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":61,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB015338":null,"HPA003635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.71e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"}},{"Gene":"MAD2L1BP","Gene synonym":["CMT2","dJ261G23.1","KIAA0110"],"Ensembl":"ENSG00000124688","Gene description":"MAD2L1 binding protein","Uniprot":["Q15013"],"Chromosome":"6","Position":"43629540-43640941","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"55.5","Megakaryocytes":"55.6","Platelets":"98.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"98.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"2726615.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"534831.7"},"Antibody":["HPA028729"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear membrane","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":31,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA028729":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.61e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"MAD2L2","Gene synonym":["FANCV","MAD2B","POLZ2","REV7"],"Ensembl":"ENSG00000116670","Gene description":"Mitotic arrest deficient 2 like 2","Uniprot":["Q9UI95"],"Chromosome":"1","Position":"11658918-11691811","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","DNA repair","Mitosis","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Fanconi anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"941.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"941.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"61186.3"},"Antibody":["HPA003882","CAB008110"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":186,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB008110":null,"HPA003882":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.16e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.48e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.42e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"}},{"Gene":"MAEL","Gene synonym":["CT128","FLJ14904","SPATA35"],"Ensembl":"ENSG00000143194","Gene description":"Maelstrom spermatogenic transposon silencer","Uniprot":["Q96JY0"],"Chromosome":"1","Position":"166975582-167022214","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","RNA-mediated gene silencing","Spermatogenesis"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"testis":"148.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"132.8","Early primary spermatocytes":"327.8","Early spermatids":"1466.1","Late primary spermatocytes":"1237.1","Late spermatids":"496.7","Oocytes":"244.1","Undifferentiated spermatogonia":"118.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1466.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"10.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Gallbladder cancer":"7.6","Myeloma":"9.1","Uterine cancer":"7.2"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"thalamus":"1.1"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"17979","Protein cell type specific Intensity":{"Oocytes":"1797877.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA078602"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA078602":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"}},{"Gene":"MAF1","Gene synonym":["DKFZp586G1123"],"Ensembl":"ENSG00000179632","Gene description":"MAF1 homolog, negative regulator of RNA polymerase III","Uniprot":["Q9H063"],"Chromosome":"8","Position":"144104461-144107611","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"210.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"223886.8","Large ducts":"458475.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"292","Protein tissue specific Intensity":{"bone marrow":"34615.2","lymphoid tissue":"23775.0"},"Antibody":["HPA024821","HPA058548","HPA072409"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA024821":null,"HPA058548":null,"HPA072409":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"MAGI1","Gene synonym":["AIP3","BAIAP1","BAP1","MAGI-1","TNRC19","WWP3"],"Ensembl":"ENSG00000151276","Gene description":"Membrane associated guanylate kinase, WW and PDZ domain containing 1","Uniprot":["Q96QZ7"],"Chromosome":"3","Position":"65353525-66038918","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"2121.6","Renal collecting duct intercalated cells":"8162.6","Retinal horizontal cells":"2414.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"8162.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"1566092.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"12673210.2"},"Antibody":["HPA031851","HPA031853","HPA077002"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":31,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA031851":null,"HPA031853":null,"HPA077002":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.05e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"}},{"Gene":"MAGI3","Gene synonym":["MAGI-3"],"Ensembl":"ENSG00000081026","Gene description":"Membrane associated guanylate kinase, WW and PDZ domain containing 3","Uniprot":["Q5TCQ9"],"Chromosome":"1","Position":"113390515-113685923","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"32.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"1287.9","Renal collecting duct intercalated cells":"1059.8","Transitional alveolar cells":"1217.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"1287.9","Ductal cells":"1059.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Lung - Alveolar cells type 1","Spleen - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"1186947.7","Neurons":"1176933.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008444"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":15,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA008444":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.00e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.99e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.74e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"}},{"Gene":"MAK","Gene synonym":["dJ417M14.2","RP62"],"Ensembl":"ENSG00000111837","Gene description":"Male germ cell associated kinase","Uniprot":["P20794"],"Chromosome":"6","Position":"10762723-10838553","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"retina":"110.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"1004.0","Epicardial cells":"484.4","Neutrophils":"258.1","Rod photoreceptor cells":"1372.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"484.4","Neuronal cells":"1372.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"neutrophil":"6.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"6.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"66422","Protein cell type specific Intensity":{"Fallopian tube cells":"6642201.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"263","Protein tissue specific Intensity":{"fallopian tube":"26265.4"},"Antibody":["HPA077174"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Plasma membrane","Basal body","Cytosol","Connecting piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":7,"Subcellular main location":["Nucleoplasm","Basal body","Cytosol","Connecting piece"],"Subcellular additional location":["Nucleoli","Plasma membrane","Principal piece","End piece"],"Antibody RRID":{"HPA077174":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"}},{"Gene":"MALL","Gene synonym":["BENE"],"Ensembl":"ENSG00000144063","Gene description":"Mal, T cell differentiation protein like","Uniprot":["Q13021"],"Chromosome":"2","Position":"110083870-110116022","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"482.8","intestine":"221.6","vagina":"189.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"21.0","Colonocytes":"20.1","Enterocytes":"53.9","Esophageal apical cells":"71.1","Esophageal suprabasal cells":"23.1","Ocular epithelial cells":"44.6","Prostatic club cells":"22.8","Prostatic hillock cells":"19.7","Transitional alveolar cells":"19.5","Urothelial cells":"50.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"71.1","Barrier epithelial cells":"50.3","Enterocytes":"53.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"18","RNA single nuclei brain specific nCPM":{"endothelial cell":"4.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"8.2","neutrophil":"2.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"8.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adrenal gland - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Lung - Alveolar cells type 2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051410"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":51,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051410":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-3"}},{"Gene":"MAP1LC3B","Gene synonym":["ATG8F"],"Ensembl":"ENSG00000140941","Gene description":"Microtubule associated protein 1 light chain 3 beta","Uniprot":["Q9GZQ8"],"Chromosome":"16","Position":"87383953-87404779","Protein class":["Predicted intracellular proteins"],"Biological process":["Autophagy","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"929.3","Neutrophils":"1133.5","Syncytiotrophoblasts":"849.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1133.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Endothelial cells","Liver - Neutrophils","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB037216","HPA042824","HPA052474","HPA052484","HPA053767"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":177,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Basal body","Cytosol"],"Antibody RRID":{"CAB037216":null,"HPA042824":null,"HPA052474":null,"HPA052484":null,"HPA053767":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.93e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.59e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"}},{"Gene":"MAP2K2","Gene synonym":["MEK2","PRKMK2"],"Ensembl":"ENSG00000126934","Gene description":"Mitogen-activated protein kinase kinase 2","Uniprot":["P36507"],"Chromosome":"19","Position":"4090321-4124122","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes","Cardiomyopathy","Disease variant","Ectodermal dysplasia","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"291.0","Erythrocyte progenitors":"318.8","Esophageal apical cells":"392.2","Late spermatids":"1280.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1280.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB003835","HPA051993"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":122,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"CAB003835":null,"HPA051993":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.03e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"}},{"Gene":"MAP3K14","Gene synonym":["FTDCR1B","HS","HSNIK","NIK"],"Ensembl":"ENSG00000006062","Gene description":"Mitogen-activated protein kinase kinase kinase 14","Uniprot":["Q99558"],"Chromosome":"17","Position":"45263119-45317029","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"141.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"88.8"},"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027269","HPA027270"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":72,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":["Nucleoplasm","Nucleoli fibrillar center"],"Antibody RRID":{"HPA027269":null,"HPA027270":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"}},{"Gene":"MAP3K19","Gene synonym":["FLJ23074","RCK","YSK4"],"Ensembl":"ENSG00000176601","Gene description":"Mitogen-activated protein kinase kinase kinase 19","Uniprot":["Q56UN5"],"Chromosome":"2","Position":"134964485-135047468","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"8.5","fallopian tube":"17.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"89.5","Cone photoreceptor cells":"89.0","Early spermatids":"94.7","Endometrial ciliated cells":"191.4","Ependymal cells":"474.7","Epididymal efferent duct ciliated cells":"156.1","Fallopian tube ciliated cells":"225.9","Late spermatids":"252.6","Respiratory ciliated cells":"379.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"474.7","Spermatogenic cell types":"252.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"509.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"10695","Protein tissue specific Intensity":{"lung":"1069533.2"},"Antibody":["HPA011388"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA011388":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"}},{"Gene":"MAP3K9","Gene synonym":["MEKK9","MLK1","PRKE1"],"Ensembl":"ENSG00000006432","Gene description":"Mitogen-activated protein kinase kinase kinase 9","Uniprot":["P80192"],"Chromosome":"14","Position":"70722526-70809534","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Apoptosis","Stress response","Transcription","Transcription regulation"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"16.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"266.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"266.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Kidney - Macrophages","Lung - Alveolar cells type 2","Skin - Keratinocyte (granular)","Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1813","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"145563.8","Microglia and Neuropil":"177301.3","Neurons":"276306.7","T-cells":"126134.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"113","Protein tissue specific Intensity":{"cerebral cortex":"11264.8"},"Antibody":["HPA000942"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":"Intracellular and membrane","Secretome function":"Transcription","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":13,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA000942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"}},{"Gene":"MAP6","Gene synonym":["FLJ41346","KIAA1878","MAP6-N","STOP"],"Ensembl":"ENSG00000171533","Gene description":"Microtubule associated protein 6","Uniprot":["Q96JE9"],"Chromosome":"11","Position":"75586918-75669038","Protein class":["Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":["Calmodulin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"83.1","choroid plexus":"86.5","pituitary gland":"73.9","retina":"89.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"308.4","Corticotrophs":"90.6","Ependymal cells":"112.9","Fallopian tube ciliated cells":"90.3","Gonadotrophs":"92.1","Lactotrophs":"155.8","Other brain neurons":"94.8","Podocytes":"258.9","Respiratory ciliated cells":"122.6","Retinal bipolar cells":"139.7","Somatotrophs":"139.1","Thyrotrophs":"284.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"122.6","Neuronal cells":"308.4","Pituitary endocrine cells":"284.6","Renal nephron cells":"258.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"45.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"32.0"},"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Lung - Respiratory ciliated cells","Pancreas - Alpha cells","Skeletal muscle - Fibroblasts","Skin - Eccrine sweat gland cells","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"295941531.7","Microglia and Neuropil":"360077009.4","Neurons":"185301580.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"554331863.2"},"Antibody":["CAB015442","CAB022600","HPA039061","HPA039062"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB015442":null,"CAB022600":null,"HPA039061":null,"HPA039062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.35e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.33e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"}},{"Gene":"MAP6D1","Gene synonym":["FLJ12748","SL21"],"Ensembl":"ENSG00000180834","Gene description":"MAP6 domain containing 1","Uniprot":["Q9H9H5"],"Chromosome":"3","Position":"183815922-183825594","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Calmodulin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"120.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Oligodendrocytes":"102.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"102.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"50.6","oligodendrocyte":"129.3","upper rhombic lip":"40.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"14.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"53257","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"6494771.2","Microglia and Neuropil":"4119232.7","Neurons":"5363159.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"46139","Protein tissue specific Intensity":{"cerebral cortex":"4613868.1"},"Antibody":["HPA037991"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA037991":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.70e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"}},{"Gene":"MAP7","Gene synonym":["E-MAP-115"],"Ensembl":"ENSG00000135525","Gene description":"Microtubule associated protein 7","Uniprot":["Q14244"],"Chromosome":"6","Position":"136342281-136550819","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"85.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oligodendrocytes":"1845.9","Retinal bipolar cells":"1033.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1845.9","Neuronal cells":"1033.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2683.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"12.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"5.7","granulocytes":"12.2","monocytes":"3.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Lung - Alveolar cells type 2","Prostate - Prostate glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"6489168.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"13602245.0","kidney":"19254001.3"},"Antibody":["HPA029712","HPA029713"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":55,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Microtubules"],"Antibody RRID":{"HPA029712":null,"HPA029713":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.69e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.68e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.09e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"}},{"Gene":"MAPK10","Gene synonym":["JNK3","p493F12","p54bSAPK","PRKM10"],"Ensembl":"ENSG00000109339","Gene description":"Mitogen-activated protein kinase 10","Uniprot":["P53779"],"Chromosome":"4","Position":"85990007-86594625","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":["Biological rhythms"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"73.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1652.4","Bergmann glia":"1620.1","Choroid plexus epithelial cells":"2097.0","Corticotrophs":"1206.0","Ependymal cells":"2326.9","Pituicytes\/FSCs":"1383.6","Respiratory ciliated cells":"1789.2","Somatotrophs":"1334.5","Thyrotrophs":"1412.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2326.9","Glial cells":"1652.4","Pituitary endocrine cells":"1412.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Adipocytes (Breast)","Liver - Hepatic stellate cells","Lung - Respiratory ciliated cells","Skeletal muscle - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"40869","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3178328.7","Microglia and Neuropil":"5548779.5","Neurons":"3533624.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"70488","Protein tissue specific Intensity":{"cerebral cortex":"7048843.9"},"Antibody":["CAB022625","HPA068627","HPA071800"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":26,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB022625":null,"HPA068627":null,"HPA071800":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":10,"Subcellular main location":["Nucleoplasm","Nucleoli","Nucleoli rim","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB025854":null,"HPA007667":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":9,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles","Cell Junctions"],"Antibody RRID":{"HPA002704":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":37,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Microtubules","Primary cilium"],"Antibody RRID":{"CAB005184":null,"HPA030262":null,"HPA047825":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"}},{"Gene":"MAPK8","Gene synonym":["JNK","JNK1","PRKM8","SAPK1"],"Ensembl":"ENSG00000107643","Gene description":"Mitogen-activated protein kinase 8","Uniprot":["P45983"],"Chromosome":"10","Position":"48306639-48439360","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":["Biological rhythms"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"4834079.7","Neurons":"5776955.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"8746593.8"},"Antibody":["CAB004463","CAB069396","HPA071800"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":91,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB004463":null,"CAB069396":null,"HPA071800":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.29e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"}},{"Gene":"MAPK8IP1","Gene synonym":["IB1","JIP-1","JIP1","PRKM8IP"],"Ensembl":"ENSG00000121653","Gene description":"Mitogen-activated protein kinase 8 interacting protein 1","Uniprot":["Q9UQF2"],"Chromosome":"11","Position":"45885651-45906465","Protein class":["Cancer-related genes","Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Diabetes mellitus","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"255.8","pituitary gland":"113.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"49.6","Gonadotrophs":"64.0","Late spermatids":"43.2","Oligodendrocytes":"76.1","Pancreatic islet cells":"38.5","Retinal horizontal cells":"52.1","Somatotrophs":"38.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"76.1","Neuronal cells":"52.1","Pituitary endocrine cells":"64.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"102.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"110.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"572276.0","Microglia and Neuropil":"348164.2","Neurons":"288335.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"26633","Protein tissue specific Intensity":{"cerebral cortex":"2663294.0"},"Antibody":["HPA058921","HPA070332","HPA079657"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":32,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA058921":null,"HPA070332":null,"HPA079657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.59e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"}},{"Gene":"MAPKAP1","Gene synonym":["MGC2745","MIP1","SIN1"],"Ensembl":"ENSG00000119487","Gene description":"MAPK associated protein 1","Uniprot":["Q9BPZ7"],"Chromosome":"9","Position":"125437393-125707234","Protein class":["Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"5357777.4","Granulosa cells":"3372705.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"8051985.5"},"Antibody":["HPA029091","HPA029092"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":29,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Cytosol"],"Antibody RRID":{"HPA029091":null,"HPA029092":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.63e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"}},{"Gene":"MAPKBP1","Gene synonym":["KIAA0596","NPHP20"],"Ensembl":"ENSG00000137802","Gene description":"Mitogen-activated protein kinase binding protein 1","Uniprot":["O60336"],"Chromosome":"15","Position":"41774434-41827855","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Nephronophthisis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"69.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"256.6","Cone photoreceptor cells":"335.4","Sertoli cells":"216.1","Suprabasal keratinocytes":"222.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"256.6","Neuronal cells":"335.4","Suprabasal cells":"222.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1041516.6","Keratinocytes":"771329.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"316","Protein tissue specific Intensity":{"fallopian tube":"32064.5","lymphoid tissue":"28560.9","ovary":"34269.0"},"Antibody":["HPA030832","HPA030833"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":51,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA030832":null,"HPA030833":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"}},{"Gene":"MAPRE3","Gene synonym":["EB3","RP3"],"Ensembl":"ENSG00000084764","Gene description":"Microtubule associated protein RP\/EB family member 3","Uniprot":["Q9UPY8"],"Chromosome":"2","Position":"26970637-27027219","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"161.0","skeletal muscle":"139.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"554.1","Fallopian tube ciliated cells":"166.3","Late spermatids":"402.0","Respiratory ciliated cells":"153.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"554.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"3.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Pituitary gland - Lactotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"36553230.6","Microglia and Neuropil":"41526983.2","Neurons":"43309318.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"81800347.0"},"Antibody":["HPA009263"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":72,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA009263":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"}},{"Gene":"MARCHF10","Gene synonym":["FLJ35757","MARCH-X","MARCH10","RNF190"],"Ensembl":"ENSG00000173838","Gene description":"Membrane associated ring-CH-type finger 10","Uniprot":["Q8NA82"],"Chromosome":"17","Position":"62701314-62808344","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"130.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"618.2","Ependymal cells":"211.5","Fallopian tube ciliated cells":"142.3","Gonadotrophs":"141.9","Late primary spermatocytes":"357.1","Late spermatids":"1992.4","Respiratory ciliated cells":"245.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1992.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"60.3","ependymal cell":"217.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"4.0"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA023322":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"}},{"Gene":"MARCHF11","Gene synonym":["MARCH-XI","MARCH11","RNF226"],"Ensembl":"ENSG00000183654","Gene description":"Membrane associated ring-CH-type finger 11","Uniprot":["A6NNE9"],"Chromosome":"5","Position":"16067139-16180762","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"78.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"124.7","Cardiomyocytes":"611.8","Early spermatids":"162.5","Gonadotrophs":"78.0","Lactotrophs":"142.7","Late primary spermatocytes":"163.6","Other brain neurons":"87.5","Retinal amacrine cells":"125.3","Retinal ganglion cells":"305.2","Somatotrophs":"355.4","Thyrotrophs":"503.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Myocytes":"611.8","Neuronal cells":"305.2","Pituitary endocrine cells":"503.0","Spermatogenic cell types":"163.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"578.7","mammillary body":"481.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"6.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"12","RNA cell line specific nTPM":{"Neuroblastoma":"83.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"35","Protein cell type specific Intensity":{"Microglia and Neuropil":"3533.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"618","Protein tissue specific Intensity":{"cerebral cortex":"61766.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MARCHF3","Gene synonym":["MARCH-III","MARCH3","MGC48332","RNF173"],"Ensembl":"ENSG00000173926","Gene description":"Membrane associated ring-CH-type finger 3","Uniprot":["Q86UD3"],"Chromosome":"5","Position":"126867714-127030558","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Endocytosis","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Mast cells":"895.6","Microglia":"462.1","Neutrophils":"550.0","Retinal horizontal cells":"482.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mast cells":"895.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"430.3","central nervous system macrophage":"575.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"10.6","naive B-cell":"12.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"12.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA043406":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"}},{"Gene":"MARCHF7","Gene synonym":["AXOT","MARCH-VII","MARCH7","RNF177"],"Ensembl":"ENSG00000136536","Gene description":"Membrane associated ring-CH-type finger 7","Uniprot":["Q9H992"],"Chromosome":"2","Position":"159712457-159771027","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"586.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"505470.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014275","HPA022152"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":42,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA014275":null,"HPA022152":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.90e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.41e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.63e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"}},{"Gene":"MARCHF8","Gene synonym":["c-MIR","CMIR","MARCH-VIII","MARCH8","MIR","RNF178"],"Ensembl":"ENSG00000165406","Gene description":"Membrane associated ring-CH-type finger 8","Uniprot":["Q5T0T0"],"Chromosome":"10","Position":"45454585-45594906","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Immunity","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"291.9","Early spermatids":"393.3","Late spermatids":"165.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"291.9","Spermatogenic cell types":"393.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014597"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014597":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.17e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"}},{"Gene":"MARVELD2","Gene synonym":["DFNB49","FLJ30532","MRVLDC2","TRIC"],"Ensembl":"ENSG00000152939","Gene description":"MARVEL domain containing 2","Uniprot":["Q8N4S9"],"Chromosome":"5","Position":"69415065-69444330","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Hearing"],"Molecular function":null,"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"thyroid gland":"14.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"26.6","Distal convoluted tubule cells":"44.4","Loop of henle epithelial cells":"43.1","Papillary tip epithelial cells":"26.1","Renal collecting duct intercalated cells":"31.6","Renal collecting duct principal cells":"21.7","Renal connecting tubule cells":"22.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"26.6","Ductal cells":"31.6","Renal nephron cells":"44.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"20.8","endothelial cell":"45.8","ependymal cell":"16.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Colon - Colon enterocytes","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"8","RNA mouse brain regional specific nTPM":{"cerebellum":"7.9"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"454415.2","Distal tubules":"671794.0","Fallopian tube cells":"374270.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"291","Protein tissue specific Intensity":{"liver":"29125.3"},"Antibody":["HPA018119","HPA061726"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":4,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA018119":null,"HPA061726":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.21e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.86e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"}},{"Gene":"MAST1","Gene synonym":["KIAA0973","SAST"],"Ensembl":"ENSG00000105613","Gene description":"Microtubule associated serine\/threonine kinase 1","Uniprot":["Q9Y2H9"],"Chromosome":"19","Position":"12833951-12874952","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"92.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"103.4","Brain inhibitory neurons":"75.7","Cone photoreceptor cells":"101.4","Early spermatids":"44.9","Lactotrophs":"62.9","Late spermatids":"62.8","Other brain neurons":"107.5","Retinal amacrine cells":"150.4","Retinal bipolar cells":"87.8","Retinal ganglion cells":"193.1","Retinal horizontal cells":"84.1","Rod photoreceptor cells":"75.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"42.5","Neuronal cells":"193.1","Pituitary endocrine cells":"62.9","Spermatogenic cell types":"62.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"23.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":17,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA028181":null,"HPA073106":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.75e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"}},{"Gene":"MAST2","Gene synonym":["KIAA0807","MAST205"],"Ensembl":"ENSG00000086015","Gene description":"Microtubule associated serine\/threonine kinase 2","Uniprot":["Q6P0Q8"],"Chromosome":"1","Position":"45786987-46036122","Protein class":["Cancer-related genes","Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"161.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"352.0","Cone photoreceptor cells":"339.5","Enterocytes":"277.2","Myonuclei":"930.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"930.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":25,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039722":null,"HPA040155":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.05e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"MAT1A","Gene synonym":["MAT","MATA1","SAMS","SAMS1"],"Ensembl":"ENSG00000151224","Gene description":"Methionine adenosyltransferase 1A","Uniprot":["Q00266"],"Chromosome":"10","Position":"80271820-80289658","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"liver":"1259.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"59","RNA single cell type specific nCPM":{"Hepatocytes":"6544.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"59","RNA single cell type group specific nCPM":{"Hepatocytes":"6544.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"4.5","ependymal cell":"18.4","fibroblast":"4.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"36","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"194.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"8.6","skin cancer":"7.2"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"529786838.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"195887834.0"},"Antibody":["HPA048627","HPA069459"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1200000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA048627":null,"HPA069459":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.75e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.98e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"}},{"Gene":"MATCAP2","Gene synonym":["KIAA0895"],"Ensembl":"ENSG00000164542","Gene description":"Microtubule associated tyrosine carboxypeptidase 2","Uniprot":["Q8NCT3"],"Chromosome":"7","Position":"36324152-36390125","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"20.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"101.4","Early spermatids":"121.8","Endometrial ciliated cells":"107.3","Gastric chief cells":"104.8","Late spermatids":"108.2","Parietal cells":"100.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"107.3","Gastric glandular cells":"104.8","Neuronal cells":"101.4","Spermatogenic cell types":"121.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Cell Junctions","Cytosol"],"Antibody RRID":{"HPA021036":null,"HPA061066":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.73e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"}},{"Gene":"MBD1","Gene synonym":["CXXC3","PCM1"],"Ensembl":"ENSG00000141644","Gene description":"Methyl-CpG binding domain protein 1","Uniprot":["Q9UIS9"],"Chromosome":"18","Position":"50266882-50281774","Protein class":["Cancer-related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"276.2","Late spermatids":"151.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"276.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"2954062.8","T-cells":"2753140.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"4877789.2"},"Antibody":["CAB009017","CAB036003","HPA068850"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":30,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB009017":null,"CAB036003":null,"HPA068850":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.90e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.56e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.49e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"}},{"Gene":"MBD3L1","Gene synonym":["MBD3L"],"Ensembl":"ENSG00000170948","Gene description":"Methyl-CpG binding domain protein 3 like 1","Uniprot":["Q8WWY6"],"Chromosome":"19","Position":"8832377-8843340","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"25.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"369.4","Late primary spermatocytes":"249.9","Late spermatids":"168.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"369.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043121","HPA046753"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":56,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043121":null,"HPA046753":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":44,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA021876":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"}},{"Gene":"MCHR2","Gene synonym":["GPR145","MCH2","MCH2R","SLT"],"Ensembl":"ENSG00000152034","Gene description":"Melanin concentrating hormone receptor 2","Uniprot":["Q969V1"],"Chromosome":"6","Position":"99918519-99994247","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"brain":"5.1","testis":"1.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"19.7","Brain inhibitory neurons":"7.9","Late primary spermatocytes":"3.4","Late spermatids":"4.4","Medullary thymic epithelial cells":"2.4","Retinal amacrine cells":"6.2","Retinal pigment epithelial cells":"4.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"19.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer intratelencephalic":"69.1","upper-layer intratelencephalic":"116.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Vesicles","Primary cilium tip","Basal body"],"Antibody RRID":{"HPA030115":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MCIDAS","Gene synonym":["IDAS","MCI","MCIN"],"Ensembl":"ENSG00000234602","Gene description":"Multiciliate differentiation and DNA synthesis associated cell cycle protein","Uniprot":["D6RGH6"],"Chromosome":"5","Position":"55219564-55227315","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cilium biogenesis\/degradation","Transcription","Transcription regulation"],"Molecular function":["Activator"],"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"2.6","stomach 1":"1.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Respiratory deuterosomal cells":"57.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"57.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049981","HPA058073"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":3,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA049981":null,"HPA058073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MCM4","Gene synonym":["CDC21","CDC54","hCdc21","MGC33310","P1-Cdc21"],"Ensembl":"ENSG00000104738","Gene description":"Minichromosome maintenance complex component 4","Uniprot":["P33991"],"Chromosome":"8","Position":"47960185-47978160","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","DNA replication"],"Molecular function":["DNA-binding","Helicase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"52.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"160.3","Erythrocyte progenitors":"288.2","Late primary spermatocytes":"147.1","Late spermatids":"110.6","Megakaryocyte progenitors":"134.0","Monocyte progenitors":"123.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"288.2","Megakaryocytes":"134.0","Mononuclear phagocytes":"123.6","Spermatogenic cell types":"160.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Mitotic cells (Lung)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"59899345.6","Neutrophils":"47519810.5","Oocytes":"25289949.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"55638085.7"},"Antibody":["CAB004497","HPA004873","HPA031052"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"85000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":90,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB004497":null,"HPA004873":null,"HPA031052":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.02e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.36e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.39e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.65e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.35e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.49e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"MCMDC2","Gene synonym":["C8orf45","FLJ25692"],"Ensembl":"ENSG00000178460","Gene description":"Minichromosome maintenance domain containing 2","Uniprot":["Q4G0Z9"],"Chromosome":"8","Position":"66870749-66922048","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"11.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"90.2","Early spermatids":"41.7","Late primary spermatocytes":"72.8","Myonuclei":"42.8","Retinal ganglion cells":"27.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"42.8","Spermatogenic cell types":"90.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026522"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Actin filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":1,"Subcellular main location":["Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA026522":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.97e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"}},{"Gene":"MCOLN2","Gene synonym":["FLJ36691","TRP-ML2","TRPML2"],"Ensembl":"ENSG00000153898","Gene description":"Mucolipin TRP cation channel 2","Uniprot":["Q8IZK6"],"Chromosome":"1","Position":"84925583-84997113","Protein class":["Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Adaptive immunity","Calcium transport","Immunity","Innate immunity","Ion transport","Protein transport","Transport"],"Molecular function":["Calcium channel","Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"8.5","intestine":"14.1","lymphoid tissue":"12.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"69.4","B-cells":"77.0","cDC":"246.8","Colonocytes":"45.0","Early spermatids":"51.1","Endometrial luminal cells":"65.6","Late primary spermatocytes":"52.6","Macrophages":"61.3","pDCs":"165.0","T-cells":"65.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"69.4","B-cells":"77.0","dendritic cells":"246.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"15","RNA single nuclei brain specific nCPM":{"leukocyte":"62.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"29.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"B-cells":"10.3","dendritic cells":"29.6","T-cells":"8.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"lymphoma":"27.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Liver - T-cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019114"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019114":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.09e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.47e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"}},{"Gene":"MCPH1","Gene synonym":["BRIT1","FLJ12847"],"Ensembl":"ENSG00000147316","Gene description":"Microcephalin 1","Uniprot":["Q8NEM0"],"Chromosome":"8","Position":"6406592-6648508","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Intellectual disability","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008238","CAB012177"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB012177":null,"HPA008238":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.88e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"}},{"Gene":"MCRIP2","Gene synonym":["C16orf14","FAM195A","MGC15416"],"Ensembl":"ENSG00000172366","Gene description":"MAPK regulated corepressor interacting protein 2","Uniprot":["Q9BUT9"],"Chromosome":"16","Position":"636817-648474","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"47.3","liver":"57.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"230.1","Cytotrophoblasts":"246.1","Enterocytes":"245.2","Hepatocytes":"236.3","Late primary spermatocytes":"261.9","Late spermatids":"994.4","Parietal cells":"190.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"994.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"574175.0","Hepatocytes":"407597.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1626","Protein tissue specific Intensity":{"kidney":"162573.9"},"Antibody":["HPA060363"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA060363":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"}},{"Gene":"MCTP2","Gene synonym":["FLJ11175","FLJ33303"],"Ensembl":"ENSG00000140563","Gene description":"Multiple C2 and transmembrane domain containing 2","Uniprot":["Q6DN12"],"Chromosome":"15","Position":"94231538-94483952","Protein class":["Disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"19.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hematopoietic stem cells":"794.3","Mast cells":"603.1","Mesothelial cells":"621.5","Neutrophil progenitors":"1213.4","Neutrophils":"4073.1","NK-cells":"1094.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"4073.1","NK-cells":"1094.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"177.1","leukocyte":"411.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"30.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Prostate - Prostate basal glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"1444833.8","Pancreas epithelial cells":"1393682.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"242499.6"},"Antibody":["HPA051176","HPA070541"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA051176":null,"HPA070541":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"}},{"Gene":"MDGA2","Gene synonym":["MAMDC1"],"Ensembl":"ENSG00000139915","Gene description":"MAM domain containing glycosylphosphatidylinositol anchor 2","Uniprot":["Q7Z553"],"Chromosome":"14","Position":"46839629-47675605","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"brain":"3.4","retina":"4.1","testis":"3.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"1067.3","Brain inhibitory neurons":"1626.5","Breast lactating cells":"951.9","Oligodendrocyte progenitor cells":"2818.7","Oligodendrocytes":"766.7","Other brain neurons":"1785.0","Pituicytes\/FSCs":"443.1","Retinal amacrine cells":"1150.8","Retinal bipolar cells":"2680.9","Retinal ganglion cells":"1104.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"2818.7","Neuronal cells":"2680.9","Secretory cells":"951.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"1.9","Testicular Germ Cell Tumor (TCGA)":"1.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"2.2"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"2207209.2","Neurons":"1806021.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"78617","Protein tissue specific Intensity":{"cerebral cortex":"7861738.0"},"Antibody":["HPA003084"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA003084":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MDH1B","Gene synonym":["FLJ25341","RP11-95H11"],"Ensembl":"ENSG00000138400","Gene description":"Malate dehydrogenase 1B","Uniprot":["Q5I0G3"],"Chromosome":"2","Position":"206737763-206765328","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"19.8","fallopian tube":"21.2","testis":"22.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"42.9","Early spermatids":"159.2","Endometrial ciliated cells":"63.8","Ependymal cells":"79.1","Epididymal efferent duct ciliated cells":"60.0","Fallopian tube ciliated cells":"117.3","Late primary spermatocytes":"347.9","Respiratory ciliated cells":"127.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"127.1","Spermatogenic cell types":"347.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"89.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"32.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA073761":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"MDH2","Gene synonym":[],"Ensembl":"ENSG00000146701","Gene description":"Malate dehydrogenase 2","Uniprot":["P40926"],"Chromosome":"7","Position":"76048051-76067508","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"652.9","tongue":"562.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"569.8","Esophageal basal cells":"563.5","Esophageal suprabasal cells":"690.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8100000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":42,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA019714":null,"HPA019716":null,"HPA019848":null,"HPA026720":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.76e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"}},{"Gene":"MDM1","Gene synonym":[],"Ensembl":"ENSG00000111554","Gene description":"Mdm1 nuclear protein","Uniprot":["Q8TC05"],"Chromosome":"12","Position":"68272443-68332381","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"118.5","Ependymal cells":"80.4","Megakaryocytes":"98.9","Pituitary stem cells":"69.2","Respiratory ciliated cells":"75.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"118.5","Megakaryocytes":"98.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"118.0","ependymal cell":"107.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":3,"Subcellular main location":["Centriolar satellite","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040411":null,"HPA041594":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"MDP1","Gene synonym":["FN6Pase","MGC5987"],"Ensembl":"ENSG00000213920","Gene description":"Magnesium dependent phosphatase 1","Uniprot":["Q86V88"],"Chromosome":"14","Position":"24213943-24216070","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"1.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003064","HPA070338"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA003064":null,"HPA070338":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"}},{"Gene":"MEA1","Gene synonym":["MEA"],"Ensembl":"ENSG00000124733","Gene description":"Male-enhanced antigen 1","Uniprot":["Q16626"],"Chromosome":"6","Position":"43011143-43016868","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"795.5","Late primary spermatocytes":"753.1","Late spermatids":"2897.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2897.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":16,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017921":null,"HPA073087":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.20e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"}},{"Gene":"MECOM","Gene synonym":["EVI1","KMT8E","MDS1","MDS1-EVI1","PRDM3"],"Ensembl":"ENSG00000085276","Gene description":"MDS1 and EVI1 complex locus","Uniprot":["Q03112"],"Chromosome":"3","Position":"169083499-169663775","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transcription factors"],"Biological process":["Apoptosis","Differentiation","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding","Methyltransferase","Transferase"],"Disease involvement":["Cancer-related genes","Disease variant","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"stomach 1":"69.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"1650.7","Distal convoluted tubule cells":"5676.7","Loop of henle epithelial cells":"3085.0","Mucous neck cells":"1848.9","Pancreatic acinar cells":"1684.5","Papillary tip epithelial cells":"2325.0","Pituicytes\/FSCs":"2986.7","Renal collecting duct intercalated cells":"2595.9","Renal collecting duct principal cells":"4488.7","Renal connecting tubule cells":"6139.4","Transitional alveolar cells":"1936.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"6139.4","Glial cells":"2986.7","Renal nephron cells":"5676.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"endothelial cell":"3226.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Heart muscle - Endothelial cells","Liver - Vascular endothelial cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Prostate - Urothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1169347.3","Distal tubules":"527468.5","Fallopian tube cells":"708575.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"136","Protein tissue specific Intensity":{"fallopian tube":"5861.1","Stomach":"21253.6"},"Antibody":["HPA046537"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":67,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA046537":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"}},{"Gene":"MED12L","Gene synonym":["KIAA1635","TNRC11L","TRALP","TRALPUSH"],"Ensembl":"ENSG00000144893","Gene description":"Mediator complex subunit 12L","Uniprot":["Q86YW9"],"Chromosome":"3","Position":"151085286-151437072","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Repressor"],"Disease involvement":["Autism spectrum disorder","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"3.6","testis":"3.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"470.8","Choroid plexus epithelial cells":"1516.9","Ependymal cells":"409.7","Hematopoietic stem cells":"1036.4","Megakaryocyte progenitors":"2142.2","Megakaryocyte-Erythroid progenitors":"1069.2","Pituitary stem cells":"499.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1516.9","Megakaryocytes":"2142.2","Stem cells":"1036.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1326.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.0","plasmacytoid DC":"1.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1655","Protein cell type specific Intensity":{"Neurons":"193122.7","Oocytes":"137816.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"16019490.0"},"Antibody":["HPA036807"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":40,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA036807":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.55e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MED13","Gene synonym":["KIAA0593","THRAP1","TRAP240"],"Ensembl":"ENSG00000108510","Gene description":"Mediator complex subunit 13","Uniprot":["Q9UHV7"],"Chromosome":"17","Position":"61942605-62065278","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Repressor"],"Disease involvement":["Cancer-related genes","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"700.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":82,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA067939":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":101,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitotic chromosome"],"Antibody RRID":{"HPA036798":null,"HPA057997":null,"HPA071835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.79e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.42e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"MEI4","Gene synonym":[],"Ensembl":"ENSG00000269964","Gene description":"Meiotic double-stranded break formation protein 4","Uniprot":["A8MW99"],"Chromosome":"6","Position":"77650274-77927045","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA recombination","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"3.9","pancreas":"1.9","testis":"3.2","thyroid gland":"2.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"51.0","Corticotrophs":"37.9","Differentiating spermatogonia":"36.6","Early primary spermatocytes":"36.3","Early spermatids":"76.2","Gonadotrophs":"78.0","Hematopoietic stem cells":"41.7","Lactotrophs":"38.8","Late primary spermatocytes":"108.4","Proximal tubule cells":"68.7","Sertoli cells":"85.0","Somatotrophs":"60.7","Thyrotrophs":"49.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"51.0","Pituitary endocrine cells":"78.0","Renal nephron cells":"68.7","Reproductive supporting cells":"85.0","Spermatogenic cell types":"108.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"80.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"1.7","Testicular Germ Cell Tumor (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":33,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MEIG1","Gene synonym":["bA2K17.3","SPATA39"],"Ensembl":"ENSG00000197889","Gene description":"Meiosis\/spermiogenesis associated 1","Uniprot":["Q5JSS6"],"Chromosome":"10","Position":"14959388-14988050","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"fallopian tube":"3.4","testis":"9.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"19.0","Early spermatids":"115.7","Endometrial ciliated cells":"32.5","Ependymal cells":"24.6","Epididymal efferent duct ciliated cells":"19.3","Fallopian tube ciliated cells":"45.0","Late primary spermatocytes":"164.3","Late spermatids":"19.1","Respiratory ciliated cells":"54.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Ciliated cells":"54.3","Spermatogenic cell types":"164.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"28.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"1.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"}},{"Gene":"MEIOC","Gene synonym":["C17orf104","FLJ35848"],"Ensembl":"ENSG00000180336","Gene description":"Meiosis specific with coiled-coil domain","Uniprot":["A2RUB1"],"Chromosome":"17","Position":"44656404-44690308","Protein class":["Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"44.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"76.3","Differentiating spermatogonia":"80.0","Early primary spermatocytes":"302.8","Early spermatids":"348.5","Late primary spermatocytes":"139.1","Late spermatids":"929.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"929.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Adrenocortical cancer":"64.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA027266":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"}},{"Gene":"MEMO1","Gene synonym":["C2orf4","CGI-27","MEMO"],"Ensembl":"ENSG00000162959","Gene description":"Mediator of cell motility 1","Uniprot":["Q9Y316"],"Chromosome":"2","Position":"31865060-32011230","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Astrocytes":"116.5","Bergmann glia":"144.3","Brain excitatory neurons":"176.5","Brain inhibitory neurons":"174.1","Choroid plexus epithelial cells":"141.6","Ependymal cells":"114.1","Microglia":"409.4","Oligodendrocyte progenitor cells":"159.7","Oligodendrocytes":"168.9","Other brain neurons":"175.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"141.6","Glial cells":"409.4","Neuronal cells":"176.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":18,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA042603":null,"HPA057952":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.81e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.13e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"}},{"Gene":"MEP1A","Gene synonym":["PPHA"],"Ensembl":"ENSG00000112818","Gene description":"Meprin A subunit alpha","Uniprot":["Q16819"],"Chromosome":"6","Position":"46793389-46839778","Protein class":["Enzymes","Plasma proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"101","RNA tissue specific nTPM":{"intestine":"440.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Enterocytes":"969.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Enterocytes":"969.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"15","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"7.9","ependymal cell":"2.5"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"51.1","Rectum Adenocarcinoma (TCGA)":"63.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"13","RNA cell line specific nTPM":{"colorectal cancer":"8.0","Gastric cancer":"3.2","liver cancer":"9.0"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025163":null,"HPA029416":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MEPCE","Gene synonym":["BCDIN3","FLJ20257"],"Ensembl":"ENSG00000146834","Gene description":"Methylphosphate capping enzyme","Uniprot":["Q7L2J0"],"Chromosome":"7","Position":"100428322-100434126","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"9.9","Epididymal basal cells":"13.8","Epididymal efferent duct ciliated cells":"10.9","Platelets":"17.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"17.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":200,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"CAB026384":null,"HPA051587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.34e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"}},{"Gene":"MESP1","Gene synonym":["bHLHc5","MGC10676"],"Ensembl":"ENSG00000166823","Gene description":"Mesoderm posterior bHLH transcription factor 1","Uniprot":["Q9BRJ9"],"Chromosome":"15","Position":"89749875-89751249","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Notch signaling pathway","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"15.4","prostate":"21.4","skeletal muscle":"12.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"65.3","Breast secretory cells":"100.0","Oocytes":"170.4","Prostatic glandular cells":"76.2","Respiratory secretory cells":"61.2","Salivary duct cells":"56.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"76.2","Oocytes":"170.4","Secretory cells":"100.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"16.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"23.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA069981":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"}},{"Gene":"MEST","Gene synonym":["PEG1"],"Ensembl":"ENSG00000106484","Gene description":"Mesoderm specific transcript","Uniprot":["Q5EB52"],"Chromosome":"7","Position":"130486171-130506465","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"placenta":"724.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Adipocytes":"277.8","Cytotrophoblasts":"1091.7","Migrating cytotrophoblasts":"727.0","Syncytiotrophoblasts":"1027.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"277.8","Trophoblast cells":"1091.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"656.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD8 T-cell":"24.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"9.2","granulocytes":"19.4","T-cells":"24.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"745.8","Uterine cancer":"608.1"},"RNA tissue cell type enrichment":["Breast - Adipocytes (Breast)","Skeletal muscle - Fibroblasts","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005623"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":6,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA005623":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.55e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"}},{"Gene":"METAP2","Gene synonym":["MAP2","MNPEP","p67"],"Ensembl":"ENSG00000111142","Gene description":"Methionyl aminopeptidase 2","Uniprot":["P50579"],"Chromosome":"12","Position":"95473520-95515839","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Aminopeptidase","Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"730.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"730.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB013025","HPA019095"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":142,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB013025":null,"HPA019095":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.73e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"}},{"Gene":"METTL14","Gene synonym":["KIAA1627"],"Ensembl":"ENSG00000145388","Gene description":"Methyltransferase 14, N6-adenosine-methyltransferase subunit","Uniprot":["Q9HCE5"],"Chromosome":"4","Position":"118685392-118715433","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["RNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"134.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"134.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"2570994.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"1316981.2"},"Antibody":["HPA038002"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038002":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.57e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.70e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"}},{"Gene":"METTL21A","Gene synonym":["FAM119A","HCA557b","HSPA-KMT","LOC151194"],"Ensembl":"ENSG00000144401","Gene description":"Methyltransferase 21A, HSPA lysine","Uniprot":["Q8WXB1"],"Chromosome":"2","Position":"207580631-207625928","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"156.9","Mast cells":"126.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"3536","Protein cell type specific Intensity":{"Granulosa cells":"140762.4","Neurons":"423726.7","Oocytes":"496432.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"637","Protein tissue specific Intensity":{"cerebral cortex":"51390.1","lymphoid tissue":"75910.1"},"Antibody":["HPA034712"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA034712":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"}},{"Gene":"METTL21C","Gene synonym":["C13orf39","LOC196541"],"Ensembl":"ENSG00000139780","Gene description":"Methyltransferase 21C, AARS1 lysine","Uniprot":["Q5VZV1"],"Chromosome":"13","Position":"102685747-102695044","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"epididymis":"23.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"4.8","Early spermatids":"3.3","Epididymal principal cells":"27.7","Late spermatids":"7.8","Myonuclei":"6.8","Retinal ganglion cells":"7.7","Syncytiotrophoblasts":"2.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"6.8","Neuronal cells":"7.7","Reproductive supporting cells":"27.7","Spermatogenic cell types":"7.8","Trophoblast cells":"4.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"1.3","upper-layer intratelencephalic":"1.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"25720","Protein cell type specific Intensity":{"Skeletal myofibers":"2572037.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"622","Protein tissue specific Intensity":{"skeletal muscle":"62229.4"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":["Nucleoli rim"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA040803":null,"HPA059882":null,"HPA074173":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.11e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"}},{"Gene":"METTL23","Gene synonym":["C17orf95","LOC124512"],"Ensembl":"ENSG00000181038","Gene description":"Methyltransferase like 23","Uniprot":["Q86XA0"],"Chromosome":"17","Position":"76726830-76733936","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chromatin regulator","Developmental protein","Methyltransferase","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"77.8","Late primary spermatocytes":"203.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"203.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA022889":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.32e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.67e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"}},{"Gene":"METTL24","Gene synonym":["C6orf186","dJ71D21.2"],"Ensembl":"ENSG00000053328","Gene description":"Methyltransferase like 24","Uniprot":["Q5JXM2"],"Chromosome":"6","Position":"110243940-110358349","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"189.1","Gonadotrophs":"82.0","Lactotrophs":"66.5","Oligodendrocyte progenitor cells":"52.0","Pituicytes\/FSCs":"58.4","Pituitary stem cells":"182.9","Podocytes":"80.3","Retinal horizontal cells":"70.1","Thyrotrophs":"57.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"189.1","Stem cells":"182.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"159.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"MAIT T-cell":"2.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"T-cells":"2.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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unknown location","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037441":null,"HPA037442":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"}},{"Gene":"METTL3","Gene synonym":["M6A","MT-A70","Spo8"],"Ensembl":"ENSG00000165819","Gene description":"Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit","Uniprot":["Q86U44"],"Chromosome":"14","Position":"21498133-21511342","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","Differentiation","DNA damage","Immunity","Innate immunity","Oogenesis","Spermatogenesis"],"Molecular function":["Methyltransferase","RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"176.7","Late primary spermatocytes":"177.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"177.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":23,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nuclear bodies","Golgi apparatus"],"Antibody RRID":{"HPA079662":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.50e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.46e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"}},{"Gene":"METTL6","Gene synonym":["MGC24132"],"Ensembl":"ENSG00000206562","Gene description":"Methyltransferase 6, methylcytidine","Uniprot":["Q8TCB7"],"Chromosome":"3","Position":"15381275-15440566","Protein class":["Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"263.9","Epicardial cells":"136.4","Late primary spermatocytes":"178.7","Late spermatids":"160.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"136.4","Spermatogenic cell types":"263.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":7,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035166":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.43e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"}},{"Gene":"MEX3C","Gene synonym":["FLJ38871","RKHD2","RNF194"],"Ensembl":"ENSG00000176624","Gene description":"Mex-3 RNA binding family member C","Uniprot":["Q5U5Q3"],"Chromosome":"18","Position":"51174550-51218333","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"110.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"773.2","Late spermatids":"848.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"848.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"9.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":17,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA040603":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.53e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"}},{"Gene":"MFAP3L","Gene synonym":["KIAA0626","NYD-sp9"],"Ensembl":"ENSG00000198948","Gene description":"Microfibril associated protein 3 like","Uniprot":["O75121"],"Chromosome":"4","Position":"169986597-170033031","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"42.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"3094.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3094.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"219.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"5.7","eosinophil":"1.8","neutrophil":"3.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"5.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 99: Retinal pigment epithelial cells - Retinol metabolism","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA017986":null,"HPA062306":null,"HPA077490":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.02e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.37e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.66e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.39e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"MFF","Gene synonym":["C2orf33","GL004"],"Ensembl":"ENSG00000168958","Gene description":"Mitochondrial fission factor","Uniprot":["Q9GZY8"],"Chromosome":"2","Position":"227325151-227357833","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"894.0","Late primary spermatocytes":"1010.9","Late spermatids":"3172.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3172.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"3672582.7"},"Antibody":["HPA010968","HPA074625"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":13,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA010968":null,"HPA074625":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.74e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.52e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"MFSD11","Gene synonym":["FLJ20226","FLJ22196"],"Ensembl":"ENSG00000092931","Gene description":"Major facilitator superfamily domain containing 11","Uniprot":["O43934"],"Chromosome":"17","Position":"76735865-76781449","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"234.9","Cone photoreceptor cells":"370.6","Early spermatids":"255.9","Late spermatids":"248.7","Myonuclei":"273.5","Rod photoreceptor cells":"284.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"273.5","Neuronal cells":"370.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Mitotic cells (Skin)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"63","Protein tissue specific Intensity":{"salivary gland":"6268.1"},"Antibody":["HPA022001"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA022001":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.84e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"MFSD14A","Gene synonym":["DKFZP564L0864","HIAT1"],"Ensembl":"ENSG00000156875","Gene description":"Major facilitator superfamily domain containing 14A","Uniprot":["Q96MC6"],"Chromosome":"1","Position":"100038095-100083377","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"123.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"15.4","Epididymal basal cells":"16.2","Epididymal clear cells":"14.3","Oligodendrocytes":"24.1","Other brain neurons":"18.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"24.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"187.7"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"23","Protein tissue specific Intensity":{"lymphoid tissue":"2329.5","salivary gland":"2304.4"},"Antibody":["HPA073127","HPA073681"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA073127":null,"HPA073681":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.87e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"MFSD4B","Gene synonym":["KIAA1919","MGC33953","SLC60A2"],"Ensembl":"ENSG00000173214","Gene description":"Major facilitator superfamily domain containing 4B","Uniprot":["Q5TF39"],"Chromosome":"6","Position":"111259327-111445354","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Sodium transport","Sugar transport","Symport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"627.6","Cardiomyocytes":"795.6","Endometrial stromal cells":"863.3","Epicardial cells":"1018.8","Fibro-adipogenic progenitors":"504.6","Myonuclei":"468.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1018.8","Myocytes":"795.6","Stromal cells":"863.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031784"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031784":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.54e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"}},{"Gene":"MFSD6L","Gene synonym":["FLJ35773"],"Ensembl":"ENSG00000185156","Gene description":"Major facilitator superfamily domain containing 6 like","Uniprot":["Q8IWD5"],"Chromosome":"17","Position":"8797110-8799365","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"8.8","testis":"23.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"123.5","Late primary spermatocytes":"150.9","Late spermatids":"55.2","Respiratory ionocytes":"61.0","Salivary ionocytes":"32.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ionocytes":"61.0","Spermatogenic cell types":"150.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"8.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Pituitary gland - Somatotropes","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023164"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023164":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.95e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA055697":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MGAT4C","Gene synonym":["HGNT-IV-H"],"Ensembl":"ENSG00000182050","Gene description":"MGAT4 family member C","Uniprot":["Q9UBM8"],"Chromosome":"12","Position":"85955666-86838904","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.2","epididymis":"4.4","testis":"4.4","thyroid gland":"5.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"265.9","Astrocytes":"1383.1","Bergmann glia":"1075.4","Brain excitatory neurons":"377.4","Brain inhibitory neurons":"485.2","Corticotrophs":"241.6","Lactotrophs":"221.0","Leydig cells":"253.6","Other brain neurons":"374.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"265.9","Glial cells":"1383.1","Leydig cells":"253.6","Neuronal cells":"485.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"14","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"7.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.4","Neuroblastoma":"1.3","testis cancer":"2.7"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"HPA016418":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MGAT4D","Gene synonym":["GnT1IP"],"Ensembl":"ENSG00000205301","Gene description":"MGAT4 family member D","Uniprot":["A6NG13"],"Chromosome":"4","Position":"140442262-140498377","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"37","RNA tissue specific nTPM":{"testis":"21.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"62.8","Early spermatids":"23.0","Ependymal cells":"33.0","Late primary spermatocytes":"184.1","Late spermatids":"51.7","Respiratory ciliated cells":"13.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"184.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"ependymal cell":"34.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036523":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MGAT5B","Gene synonym":["FLJ25132","GnT-IX","GnT-VB"],"Ensembl":"ENSG00000167889","Gene description":"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B","Uniprot":["Q3V5L5"],"Chromosome":"17","Position":"76868404-76950393","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"34","RNA tissue specific nTPM":{"brain":"39.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"15.7","Bergmann glia":"56.3","Brain excitatory neurons":"29.3","Brain inhibitory neurons":"38.2","Early spermatids":"15.4","Gonadotrophs":"12.6","Late spermatids":"18.8","Oocytes":"73.7","Other brain neurons":"12.8","Retinal amacrine cells":"30.5","Retinal ganglion cells":"19.3","Thyrotrophs":"11.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"56.3","Neuronal cells":"38.2","Oocytes":"73.7","Spermatogenic cell types":"18.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper-layer intratelencephalic":"117.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"12.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3108","Protein cell type specific Intensity":{"Neurons":"310768.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011082"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytokinetic bridge","Mitotic spindle"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":2,"Subcellular main location":["Nucleoplasm","Mitotic spindle"],"Subcellular additional location":["Cytokinetic bridge"],"Antibody RRID":{"HPA011082":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MIA3","Gene synonym":["FLJ39207","KIAA0268","TANGO","TANGO1","UNQ6077"],"Ensembl":"ENSG00000154305","Gene description":"MIA SH3 domain ER export factor 3","Uniprot":["Q5JRA6"],"Chromosome":"1","Position":"222618097-222668007","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["ER-Golgi transport","Exocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Deafness","Diabetes mellitus","Dwarfism","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Prostatic glandular cells":"304.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"304.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"85928350.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"53098816.2"},"Antibody":["HPA055922","HPA056816"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4400000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":26,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA055922":null,"HPA056816":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.10e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.57e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"}},{"Gene":"MICALL1","Gene synonym":["KIAA1668","MICAL-L1","MIRAB13"],"Ensembl":"ENSG00000100139","Gene description":"MICAL like 1","Uniprot":["Q8N3F8"],"Chromosome":"22","Position":"37905657-37942822","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Endocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"67.3","Esophageal apical cells":"84.4","Esophageal suprabasal cells":"80.4","Migrating cytotrophoblasts":"63.1","Parietal cells":"93.7","Syncytiotrophoblasts":"69.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"84.4","Gastric glandular cells":"93.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Smooth muscle cells","Prostate - Smooth muscle cells","Skin - Keratinocyte (granular)","Stomach - Parietal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"1970686.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043480","HPA051956"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cell Junctions","Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":28,"Subcellular main location":["Cell Junctions","Centriolar satellite","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043480":null,"HPA051956":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.89e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"}},{"Gene":"MIEF1","Gene synonym":["FLJ20232","L0R8F8","MiD51","SMCR7L"],"Ensembl":"ENSG00000100335","Gene description":"Mitochondrial elongation factor 1","Uniprot":["Q9NQG6"],"Chromosome":"22","Position":"39499432-39518132","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"303.0","Late spermatids":"624.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"624.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"30037135.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"9737449.0"},"Antibody":["HPA061059"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Intermediate filaments","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":26,"Subcellular main location":["Intermediate filaments","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA061059":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"}},{"Gene":"MIEN1","Gene synonym":["C17orf37","C35","MGC14832","ORB3","Rdx12","XTP4"],"Ensembl":"ENSG00000141741","Gene description":"Migration and invasion enhancer 1","Uniprot":["Q9BRT3"],"Chromosome":"17","Position":"39728496-39730532","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"443.5","Esophageal suprabasal cells":"269.6","Gastric progenitor cells":"464.0","Late primary spermatocytes":"271.9","Syncytiotrophoblasts":"341.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"443.5","Proliferating cells":"464.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"293.7"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"14583939.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA056650","HPA061344"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"65000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":11,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA056650":null,"HPA061344":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"MIP","Gene synonym":["AQP0","LIM1","MP26"],"Ensembl":"ENSG00000135517","Gene description":"Major intrinsic protein of lens fiber","Uniprot":["P30301"],"Chromosome":"12","Position":"56449502-56469166","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Sensory transduction","Transport","Vision"],"Molecular function":["Eye lens protein"],"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"1.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"1.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014940"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":36,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014940":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MIPOL1","Gene synonym":["CCDC193"],"Ensembl":"ENSG00000151338","Gene description":"Mirror-image polydactyly 1","Uniprot":["Q8TD10"],"Chromosome":"14","Position":"37197894-37579125","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Prostatic glandular cells":"1813.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Glandular cells":"1813.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"1.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":60,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA002893":null,"HPA050179":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.71e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.62e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.04e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"}},{"Gene":"MKKS","Gene synonym":["BBS6"],"Ensembl":"ENSG00000125863","Gene description":"MKKS centrosomal shuttling protein","Uniprot":["Q9NPJ1"],"Chromosome":"20","Position":"10401009-10434222","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":["Chaperone"],"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Disease variant","Intellectual disability","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"73.7","Late primary spermatocytes":"94.0","Parietal cells":"113.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"113.1","Spermatogenic cell types":"94.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"163","Protein cell type specific Intensity":{"Collecting ducts":"16302.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"41","Protein tissue specific Intensity":{"liver":"4140.5"},"Antibody":["HPA041071","HPA044233"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":6,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":null,"Antibody RRID":{"HPA041071":null,"HPA044233":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"}},{"Gene":"MKRN1","Gene synonym":["RNF61"],"Ensembl":"ENSG00000133606","Gene description":"Makorin ring finger protein 1","Uniprot":["Q9UHC7"],"Chromosome":"7","Position":"140453033-140479536","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocytes":"411.5","Late primary spermatocytes":"662.7","Late spermatids":"509.7","Platelets":"409.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"411.5","Platelets":"409.0","Spermatogenic cell types":"662.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"421.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"156","Protein cell type specific Intensity":{"Distal tubules":"7663.7","Microglia and Neuropil":"8872.2","Neurons":"30189.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA000567"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":36,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA000567":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.14e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.19e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.79e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"MKRN2","Gene synonym":["HSPC070","RNF62"],"Ensembl":"ENSG00000075975","Gene description":"Makorin ring finger protein 2","Uniprot":["Q9H000"],"Chromosome":"3","Position":"12557057-12586208","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"722.3","Late spermatids":"1168.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1168.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"16875228.8"},"Antibody":["HPA037559","HPA037560"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":36,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA037559":null,"HPA037560":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.06e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"}},{"Gene":"MLF1","Gene synonym":[],"Ensembl":"ENSG00000178053","Gene description":"Myeloid leukemia factor 1","Uniprot":["P58340"],"Chromosome":"3","Position":"158571163-158607252","Protein class":["Cancer-related genes","Disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Differentiation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"170.9","testis":"340.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"5554.7","Late spermatids":"19791.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"42","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"19791.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"307.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"8.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"T-cells":"8.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":31,"Subcellular main location":["Nucleoplasm","Centrosome","Basal body","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Vesicles","Plasma membrane","Focal adhesion sites","Cytosol"],"Antibody RRID":{"HPA017852":null,"HPA079339":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.54e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"}},{"Gene":"MLIP","Gene synonym":["C6orf142","CIP","MGC18257"],"Ensembl":"ENSG00000146147","Gene description":"Muscular LMNA interacting protein","Uniprot":["Q5VWP3"],"Chromosome":"6","Position":"53929982-54266280","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"heart muscle":"186.2","liver":"119.5","skeletal muscle":"205.1","tongue":"139.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Cardiomyocytes":"2539.9","Myonuclei":"3506.9","Thymic myoid cells":"4190.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Myocytes":"3506.9","Stromal cells":"4190.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"459.2","miscellaneous":"429.2","upper-layer intratelencephalic":"657.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"16.9","skin cancer":"10.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Pancreas - Alpha cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"33139651.6","Cardiomyocytes":"59627295.0","Skeletal myofibers":"32192574.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"248927522.1","skeletal muscle":"134743003.6"},"Antibody":["HPA029252","HPA046654","HPA077663"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":1,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA029252":null,"HPA046654":null,"HPA077663":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.67e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.98e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MLLT10","Gene synonym":["AF10"],"Ensembl":"ENSG00000078403","Gene description":"MLLT10 histone lysine methyltransferase DOT1L cofactor","Uniprot":["P55197"],"Chromosome":"10","Position":"21524646-21743630","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"86.9"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"8851","Protein tissue specific Intensity":{"bone marrow":"885141.3"},"Antibody":["HPA005736","HPA005747","HPA072790"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA005736":null,"HPA005747":null,"HPA072790":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.83e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.97e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.22e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"}},{"Gene":"MLST8","Gene synonym":["GbetaL","GBL","Lst8","Pop3"],"Ensembl":"ENSG00000167965","Gene description":"MTOR associated protein, LST8 homolog","Uniprot":["Q9BVC4"],"Chromosome":"16","Position":"2204248-2209453","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"78.8","Late spermatids":"181.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"181.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"1360059.2"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB019935","HPA041841","HPA068631"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Cell Junctions"],"Antibody RRID":{"CAB019935":null,"HPA041841":null,"HPA068631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.40e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.43e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"MMAA","Gene synonym":["cblA"],"Ensembl":"ENSG00000151611","Gene description":"Metabolism of cobalamin associated A","Uniprot":["Q8IVH4"],"Chromosome":"4","Position":"145599042-145660033","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"22.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"299.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"299.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"19926249.9","Proximal tubules":"22431237.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"13171883.8"},"Antibody":["HPA037361","HPA058187"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA037361":null,"HPA058187":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.70e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.69e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.34e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.57e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.15e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"}},{"Gene":"MMACHC","Gene synonym":["cblC","DKFZP564I122"],"Ensembl":"ENSG00000132763","Gene description":"Metabolism of cobalamin associated C","Uniprot":["Q9Y4U1"],"Chromosome":"1","Position":"45500300-45513382","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"16.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"22.7","Hepatocytes":"28.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"28.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"48.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA027394":null,"HPA027399":null,"HPA027402":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.26e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"MMADHC","Gene synonym":["C2orf25","cblD","CL25022"],"Ensembl":"ENSG00000168288","Gene description":"Metabolism of cobalamin associated D","Uniprot":["Q9H3L0"],"Chromosome":"2","Position":"149569637-149587778","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"440.2","Late primary spermatocytes":"366.4","Syncytiotrophoblasts":"288.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"440.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"108","Protein tissue specific Intensity":{"Stomach":"10831.9"},"Antibody":["HPA037531","HPA037532"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037531":null,"HPA037532":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"MMEL1","Gene synonym":["MMEL2","NEPII","NL1","NL2","SEP"],"Ensembl":"ENSG00000142606","Gene description":"Membrane metalloendopeptidase like 1","Uniprot":["Q495T6"],"Chromosome":"1","Position":"2590639-2633016","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"23.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"23.0","Endometrial secretory cells":"10.7","Ependymal cells":"9.7","Foveolar cells":"3.3","Gastric chief cells":"20.7","Late primary spermatocytes":"5.4","Late spermatids":"8.4","Mucous neck cells":"4.7","Prostatic club cells":"4.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"9.7","Gastric glandular cells":"20.7","Secretory cells":"10.7","Spermatogenic cell types":"23.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"11.1","mammillary body":"4.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"17.8","Uterine Corpus Endometrial Carcinoma (TCGA)":"22.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"1.9","prostate cancer":"1.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB020786":null,"HPA007876":null,"HPA008205":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"}},{"Gene":"MMP20","Gene synonym":[],"Ensembl":"ENSG00000137674","Gene description":"Matrix metallopeptidase 20","Uniprot":["O60882"],"Chromosome":"11","Position":"102576832-102625332","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Amelogenesis imperfecta"],"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"94.3","Late primary spermatocytes":"77.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"94.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"lymphoma":"2.0","prostate cancer":"2.6"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Adipocytes (Subcutaneous)","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"7632798.2","Large ducts":"9043244.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"26704030.3","kidney":"8475377.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"}},{"Gene":"MMRN1","Gene synonym":["ECM","EMILIN4","GPIa*","MMRN"],"Ensembl":"ENSG00000138722","Gene description":"Multimerin 1","Uniprot":["Q13201"],"Chromosome":"4","Position":"89879532-89954629","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Lymphatic endothelial cells":"2482.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Endothelial cells":"2482.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"19","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"74.5","endothelial cell":"24.9","ependymal cell":"21.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"NK-cell":"6.3","plasmacytoid DC":"2.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"dendritic cells":"2.2","NK-cells":"6.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"17.0","Rhabdoid":"13.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"150000000","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA035769":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"}},{"Gene":"MMS22L","Gene synonym":["C6orf167","dJ39B17.2"],"Ensembl":"ENSG00000146263","Gene description":"MMS22 like, DNA repair protein","Uniprot":["Q6ZRQ5"],"Chromosome":"6","Position":"97142161-97283217","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["Chromatin regulator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"6.7","testis":"6.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"132.3","Erythrocyte progenitors":"181.8","Megakaryocyte progenitors":"119.6","Monocyte progenitors":"118.2","Neutrophil progenitors":"158.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"181.8","Neutrophils":"158.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":36,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA067042":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.58e-5"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"}},{"Gene":"MNS1","Gene synonym":["FLJ11222","SPATA40"],"Ensembl":"ENSG00000138587","Gene description":"Meiosis specific nuclear structural 1","Uniprot":["Q8NEH6"],"Chromosome":"15","Position":"56421544-56465137","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":["Disease variant","Heterotaxy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"21.4","fallopian tube":"20.0","testis":"45.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"356.2","Endometrial ciliated cells":"324.5","Ependymal cells":"226.3","Epididymal efferent duct ciliated cells":"491.5","Fallopian tube ciliated cells":"477.4","Late primary spermatocytes":"964.3","Oocytes":"262.5","Respiratory ciliated cells":"396.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"491.5","Oocytes":"262.5","Spermatogenic cell types":"964.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"263.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Colon - Enteric glia cells","Kidney - Fibroblasts","Liver - Hepatic stellate cells","Lung - Respiratory ciliated cells","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"7240605.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"46824","Protein tissue specific Intensity":{"fallopian tube":"4682416.0"},"Antibody":["HPA039975","HPA040382"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear speckles","Primary cilium","Basal body","Cytosol","Perinuclear theca","Flagellar centriole","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":26,"Subcellular main location":["Nucleoplasm","Nuclear speckles","Primary cilium","End piece"],"Subcellular additional location":["Basal body","Cytosol","Perinuclear theca","Flagellar centriole"],"Antibody RRID":{"HPA039975":null,"HPA040382":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.73e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.12e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"}},{"Gene":"MOBP","Gene synonym":[],"Ensembl":"ENSG00000168314","Gene description":"Myelin associated oligodendrocyte basic protein","Uniprot":["Q13875"],"Chromosome":"3","Position":"39467198-39529479","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"brain":"873.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Oligodendrocytes":"1900.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Glial cells":"1900.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2942.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"30","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"17.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"2.2"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"white matter":"10285.7"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1976127.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"204453","Protein tissue specific Intensity":{"cerebral cortex":"20445295.4"},"Antibody":["HPA035152"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytoplasmic bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":5,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA035152":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MOCS3","Gene synonym":["dJ914P20.3","UBA4"],"Ensembl":"ENSG00000124217","Gene description":"Molybdenum cofactor synthesis 3","Uniprot":["O95396"],"Chromosome":"20","Position":"50958818-50963929","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Molybdenum cofactor biosynthesis","tRNA processing"],"Molecular function":["Multifunctional enzyme","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"121.6","Late primary spermatocytes":"25.6","Late spermatids":"32.2","Tuft cells":"23.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"121.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA027556":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.82e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.49e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - 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Adipose progenitor cells","Colon - Enteric glia cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027292"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA027292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"}},{"Gene":"MON1A","Gene synonym":["MGC13272","SAND1"],"Ensembl":"ENSG00000164077","Gene description":"MON1 homolog A, secretory trafficking associated","Uniprot":["Q86VX9"],"Chromosome":"3","Position":"49907160-49930173","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"60.3","Oocytes":"184.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Oocytes":"184.2","Spermatogenic cell types":"60.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA053752":null,"HPA058032":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"MORF4L1","Gene synonym":["Eaf3","HsT17725","MEAF3","MORFRG15","MRG15"],"Ensembl":"ENSG00000185787","Gene description":"Mortality factor 4 like 1","Uniprot":["Q9UBU8"],"Chromosome":"15","Position":"78810487-78898139","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Growth regulation","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"1110.3","Late primary spermatocytes":"2195.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2195.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Fibroblasts","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"5254397.3","Pancreas epithelial cells":"4863521.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1752704.7","lymphoid tissue":"819273.7"},"Antibody":["HPA042360","HPA062010"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":82,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA042360":null,"HPA062010":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA005858":null,"HPA070703":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA057815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"}},{"Gene":"MOS","Gene synonym":[],"Ensembl":"ENSG00000172680","Gene description":"MOS proto-oncogene, serine\/threonine kinase","Uniprot":["P00540"],"Chromosome":"8","Position":"56112942-56113982","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"6.4","Late primary spermatocytes":"9.9","Microglia":"1.9","Oocytes":"4.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1.9","Oocytes":"4.6","Spermatogenic cell types":"9.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"2.1","deep-layer near-projecting":"1.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":59,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MOV10L1","Gene synonym":["CHAMP","DJ402G11.8","DKFZp434B0717"],"Ensembl":"ENSG00000073146","Gene description":"Mov10 like RISC complex RNA helicase 1","Uniprot":["Q9BXT6"],"Chromosome":"22","Position":"50089879-50161690","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Developmental protein","Helicase","Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"41.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"76.6","Early primary spermatocytes":"167.4","Early spermatids":"155.2","Late primary spermatocytes":"66.0","Late spermatids":"451.1","Undifferentiated spermatogonia":"57.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"451.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019034":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MOXD1","Gene synonym":["dJ248E1.1","DKFZP564G202","MOX"],"Ensembl":"ENSG00000079931","Gene description":"Monooxygenase DBH like 1","Uniprot":["Q6UVY6"],"Chromosome":"6","Position":"132296055-132401475","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"endometrium 1":"59.9","smooth muscle":"73.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"73.2","Decidual stromal cells":"132.8","Early spermatids":"127.8","Endometrial stromal cells":"95.5","Esophageal basal cells":"92.9","Fibroblasts":"70.0","M\u00fcller glia":"46.7","Pituicytes\/FSCs":"262.4","Salivary myoepithelial cells":"130.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"92.9","Glial cells":"262.4","Secretory gland support":"130.5","Spermatogenic cell types":"127.8","Stromal cells":"132.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"amygdala excitatory":"94.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"33","RNA blood cell specific nTPM":{"memory B-cell":"3.1","naive B-cell":"1.7","plasmacytoid DC":"5.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"41","RNA blood lineage specific nTPM":{"B-cells":"3.1","dendritic cells":"5.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"61.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adrenal gland - Fibroblasts","Colon - Enteric glia cells","Kidney - Fibroblasts","Skeletal muscle - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2812987.5","Collecting ducts":"2194941.5","Microglia and Neuropil":"3213070.5","Neurons":"1053736.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"8559322.2"},"Antibody":["HPA035740"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035740":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056091":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":18,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus","Centrosome","Basal body"],"Antibody RRID":{"HPA037485":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"}},{"Gene":"MPI","Gene synonym":[],"Ensembl":"ENSG00000178802","Gene description":"Mannose phosphate isomerase","Uniprot":["P34949"],"Chromosome":"15","Position":"74890005-74902219","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase"],"Disease involvement":["Congenital disorder of glycosylation","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"171.3","Enterocytes":"65.0","Esophageal apical cells":"70.4","Late primary spermatocytes":"60.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"171.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"160000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA007200":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.09e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.20e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"}},{"Gene":"MPL","Gene synonym":["CD110","THPOR","TPOR"],"Ensembl":"ENSG00000117400","Gene description":"MPL proto-oncogene, thrombopoietin receptor","Uniprot":["P40238"],"Chromosome":"1","Position":"43337818-43354466","Protein class":["Cancer-related genes","CD markers","Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"14.8","Hematopoietic stem cells":"40.3","Megakaryocyte progenitors":"44.2","Megakaryocytes":"30.9","Platelets":"111.2","Thymocytes":"10.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Megakaryocytes":"44.2","Platelets":"111.2","Stem cells":"40.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"3.1","upper-layer intratelencephalic":"4.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"1.4"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Leukemia":"5.9"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":3,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA007619":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-3"}},{"Gene":"MPP2","Gene synonym":["DKFZp761D0712","DLG2"],"Ensembl":"ENSG00000108852","Gene description":"MAGUK p55 scaffold protein 2","Uniprot":["Q14168"],"Chromosome":"17","Position":"43875357-43909711","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"32.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"38.3","Choroid plexus epithelial cells":"50.0","Corticotrophs":"46.4","Early primary spermatocytes":"45.4","Early spermatids":"100.4","Late spermatids":"39.1","Oligodendrocytes":"62.6","Retinal bipolar cells":"107.7","Retinal horizontal cells":"44.1","Retinal pigment epithelial cells":"38.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"62.6","Neuronal cells":"107.7","Spermatogenic cell types":"100.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"13.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026486":null,"HPA073483":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"}},{"Gene":"MPP7","Gene synonym":["FLJ32798"],"Ensembl":"ENSG00000150054","Gene description":"MAGUK p55 scaffold protein 7","Uniprot":["Q5T2T1"],"Chromosome":"10","Position":"28050993-28334486","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"34.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"381.2","Lymphatic endothelial cells":"424.1","Neutrophil progenitors":"655.5","Neutrophils":"609.7","Renal collecting duct intercalated cells":"408.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"655.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adrenal gland - Adrenal cortex cells","Lung - Alveolar cells type 2","Skeletal muscle - Skeletal myocytes","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"9824003.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"17997354.7"},"Antibody":["HPA037597","HPA037598"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":27,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA037597":null,"HPA037598":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.01e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.31e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"}},{"Gene":"MPST","Gene synonym":["MST","TST2","TUM1"],"Ensembl":"ENSG00000128309","Gene description":"Mercaptopyruvate sulfurtransferase","Uniprot":["P25325"],"Chromosome":"22","Position":"37019635-37029821","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"370.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"517.0","Enteric stem cells":"312.8","Enteric transient amplifying cells":"379.8","Enterocytes":"1169.7","Esophageal apical cells":"675.2","Esophageal suprabasal cells":"348.4","Hepatocytes":"650.0","Paneth cells":"313.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"675.2","Enterocytes":"1169.7","Hepatocytes":"650.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"37.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"224541692.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"488931502.2"},"Antibody":["HPA001240"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3600000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001240":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.71e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"}},{"Gene":"MRGBP","Gene synonym":["C20orf20","Eaf7","FLJ10914","MRG15BP"],"Ensembl":"ENSG00000101189","Gene description":"MRG domain binding protein","Uniprot":["Q9NV56"],"Chromosome":"20","Position":"62796473-62801729","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Growth regulation","Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"46.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"194.8","Late spermatids":"708.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"25","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"708.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"282380.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"5856453.7"},"Antibody":["HPA017012"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":63,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA017012":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.75e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":null,"Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA058909":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MRLN","Gene synonym":["Linc-RAM","LINC00948","M1","MLN","MUSER1"],"Ensembl":"ENSG00000227877","Gene description":"Myoregulin","Uniprot":["P0DMT0"],"Chromosome":"10","Position":"59736692-59756041","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"176.7","tongue":"137.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"116.0","Epididymal efferent duct ciliated cells":"94.4","Fallopian tube ciliated cells":"101.5","Lacrimal acinar cells":"34.4","Myonuclei":"45.5","Respiratory ciliated cells":"24.8","Rod photoreceptor cells":"69.9","Thymic myoid cells":"84.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Acinar cells":"34.4","Ciliated cells":"116.0","Myocytes":"45.5","Neuronal cells":"69.9","Stromal cells":"84.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"13.0","upper rhombic lip":"22.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"11.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"}},{"Gene":"MRM3","Gene synonym":["FLJ10581","HC90","RMTL1","RNMTL1"],"Ensembl":"ENSG00000171861","Gene description":"Mitochondrial rRNA methyltransferase 3","Uniprot":["Q9HC36"],"Chromosome":"17","Position":"782353-792509","Protein class":["Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"127.8","Late spermatids":"47.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"127.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":46,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA022534":null,"HPA023031":null,"HPA023292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.68e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"}},{"Gene":"MROH2A","Gene synonym":["HEATR7B1"],"Ensembl":"ENSG00000185038","Gene description":"Maestro heat like repeat family member 2A","Uniprot":["A6NES4"],"Chromosome":"2","Position":"233775679-233833423","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.6","thyroid gland":"1.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"2.1","Early spermatids":"5.0","Esophageal basal cells":"5.0","Hepatocytes":"2.6","Late primary spermatocytes":"2.9","Late spermatids":"8.3","Pituitary stem cells":"2.8","Proximal tubule cells":"10.8","Renal connecting tubule cells":"2.2","Undifferentiated spermatogonia":"3.9","Urothelial cells":"12.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"12.6","Basal cells":"5.0","Renal nephron cells":"10.8","Spermatogenic cell types":"8.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"12.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"2.0"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA052107":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA058316":null,"HPA060298":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":16,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038769":null,"HPA076790":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.42e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":60,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043666":null,"HPA050552":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.83e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"}},{"Gene":"MRPL18","Gene synonym":["HSPC071"],"Ensembl":"ENSG00000112110","Gene description":"Mitochondrial ribosomal protein L18","Uniprot":["Q9H0U6"],"Chromosome":"6","Position":"159789812-159798436","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":["Transport"],"Molecular function":["Chaperone","Ribonucleoprotein","Ribosomal protein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Pancreatic duct cells":"488.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"488.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":142,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA028774":null,"HPA028775":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.23e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.19e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":58,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA051657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.98e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.88e-5"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"MRPL22","Gene synonym":["HSPC158","MRP-L25","RPML25"],"Ensembl":"ENSG00000082515","Gene description":"Mitochondrial ribosomal protein L22","Uniprot":["Q9NWU5"],"Chromosome":"5","Position":"154941073-154969411","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"202.5","Late primary spermatocytes":"267.0","Oocytes":"239.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"12697847.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"987713.5"},"Antibody":["HPA047063"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":14,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA047063":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-5"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.64e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.61e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"MRPL28","Gene synonym":["MAAT1","p15"],"Ensembl":"ENSG00000086504","Gene description":"Mitochondrial ribosomal protein L28","Uniprot":["Q13084"],"Chromosome":"16","Position":"366969-371289","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"218.0","Late spermatids":"365.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"365.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"7141157.0","Large ducts":"7648814.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"960928.8","heart muscle":"3535990.6"},"Antibody":["HPA030594","CAB033542","HPA055589"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":118,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB033542":null,"HPA030594":null,"HPA055589":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"MRPL3","Gene synonym":["MRL3","RPML3"],"Ensembl":"ENSG00000114686","Gene description":"Mitochondrial ribosomal protein L3","Uniprot":["P09001"],"Chromosome":"3","Position":"131462212-131502983","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"14429884.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"10005519.5"},"Antibody":["HPA043665","HPA060132"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":76,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043665":null,"HPA060132":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.31e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.54e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.30e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.96e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"}},{"Gene":"MRPL34","Gene synonym":["L34mt","MGC24974","MGC2633"],"Ensembl":"ENSG00000130312","Gene description":"Mitochondrial ribosomal protein L34","Uniprot":["Q9BQ48"],"Chromosome":"19","Position":"17292609-17306843","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatocytes":"322.6","Late primary spermatocytes":"448.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"448.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"2852836.0","Large ducts":"3574865.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1792866.2","intestine":"1880785.3"},"Antibody":["HPA049276"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":13,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA049276":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.13e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"}},{"Gene":"MRPL36","Gene synonym":["L36mt","MRP-L36","PRPL36","RPMJ"],"Ensembl":"ENSG00000171421","Gene description":"Mitochondrial ribosomal protein L36","Uniprot":["Q9P0J6"],"Chromosome":"5","Position":"1798385-1801366","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"430.9","Esophageal basal cells":"220.8","Esophageal suprabasal cells":"202.6","Late primary spermatocytes":"498.7","Late spermatids":"598.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"598.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047238"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA047238":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.54e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.99e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"}},{"Gene":"MRPL39","Gene synonym":["C21orf92","FLJ20451","L39mt","MGC104174","MGC3400","MRP-L5","MSTP003","PRED22","PRED66","RPML5"],"Ensembl":"ENSG00000154719","Gene description":"Mitochondrial ribosomal protein L39","Uniprot":["Q9NYK5"],"Chromosome":"21","Position":"25585656-25607517","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":["Leigh syndrome","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"234.3","Late primary spermatocytes":"347.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"347.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"17105820.2"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018331"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":43,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA018331":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"}},{"Gene":"MRPL40","Gene synonym":["MRP-L22","NLVCF"],"Ensembl":"ENSG00000185608","Gene description":"Mitochondrial ribosomal protein L40","Uniprot":["Q9NQ50"],"Chromosome":"22","Position":"19432545-19436075","Protein class":["Plasma proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"226.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"32021895.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"9504239.2"},"Antibody":["HPA006181"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":61,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA006181":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.40e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"MRPL42","Gene synonym":["HSPC204","MRP-L31","MRPL31","MRPS32","PTD007","RPML31"],"Ensembl":"ENSG00000198015","Gene description":"Mitochondrial ribosomal protein L42","Uniprot":["Q9Y6G3"],"Chromosome":"12","Position":"93467514-93516214","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"332.0","Late primary spermatocytes":"598.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"598.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"8906402.5"},"Antibody":["HPA039398"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":140,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA039398":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.19e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.46e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.13e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":13,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA073022":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"}},{"Gene":"MRPL46","Gene synonym":["C15orf4","LIECG2","P2ECSL"],"Ensembl":"ENSG00000259494","Gene description":"Mitochondrial ribosomal protein L46","Uniprot":["Q9H2W6"],"Chromosome":"15","Position":"88459477-88467390","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enteric stem cells":"19.0","Enteric transient amplifying cells":"21.3","Enterocytes":"15.7","Parietal cells":"35.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"35.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"13357716.2"},"Antibody":["HPA050166","HPA076046"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cell Junctions","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":75,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Cell Junctions","Cytosol"],"Antibody RRID":{"HPA050166":null,"HPA076046":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.53e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.18e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"}},{"Gene":"MRPL47","Gene synonym":["CGI-204","NCM1"],"Ensembl":"ENSG00000136522","Gene description":"Mitochondrial ribosomal protein L47","Uniprot":["Q9HD33"],"Chromosome":"3","Position":"179588285-179604649","Protein class":["Plasma proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"352.6","Gastric progenitor cells":"288.4","Late primary spermatocytes":"728.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"728.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"31397937.0"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037553","HPA047779"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":30,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA037553":null,"HPA047779":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.93e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.41e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.58e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"}},{"Gene":"MRPL51","Gene synonym":["bMRP64","CDA09","HSPC241","MRP64"],"Ensembl":"ENSG00000111639","Gene description":"Mitochondrial ribosomal protein L51","Uniprot":["Q4U2R6"],"Chromosome":"12","Position":"6491886-6493841","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"903.5","Esophageal basal cells":"607.8","Esophageal suprabasal cells":"661.2","Late primary spermatocytes":"1345.7","Late spermatids":"630.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1345.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"561","Protein cell type specific Intensity":{"Large ducts":"56089.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"160827.2","lymphoid tissue":"189339.0","salivary gland":"309652.3"},"Antibody":["HPA039923"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":96,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA039923":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.23e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.08e-10"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.53e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"}},{"Gene":"MRPL52","Gene synonym":[],"Ensembl":"ENSG00000172590","Gene description":"Mitochondrial ribosomal protein L52","Uniprot":["Q86TS9"],"Chromosome":"14","Position":"22829879-22835037","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"405.6","Gastric progenitor cells":"588.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"588.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"612335.1","Large ducts":"1103265.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"6808137.1"},"Antibody":["HPA012319"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":98,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA012319":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":14,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA042117":null,"HPA046767":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.62e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-4"}},{"Gene":"MRPL9","Gene synonym":[],"Ensembl":"ENSG00000143436","Gene description":"Mitochondrial ribosomal protein L9","Uniprot":["Q9BYD2"],"Chromosome":"1","Position":"151759647-151763496","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"125.5","Extravillous trophoblasts":"143.9","Migrating cytotrophoblasts":"129.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"8869124.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008579","HPA078399"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":105,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA008579":null,"HPA078399":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.19e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"}},{"Gene":"MRPS11","Gene synonym":["FLJ22512","FLJ23406","HCC-2"],"Ensembl":"ENSG00000181991","Gene description":"Mitochondrial ribosomal protein S11","Uniprot":["P82912"],"Chromosome":"15","Position":"88467453-88480776","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"173.9","Esophageal suprabasal cells":"144.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1261252.9"},"Antibody":["HPA043752","HPA050345"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":14,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA043752":null,"HPA050345":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.52e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.29e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":60,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA028100":null,"HPA028134":null,"HPA067137":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.75e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"}},{"Gene":"MRPS17","Gene synonym":["HSPC011","MRP-S17","RPMS17"],"Ensembl":"ENSG00000239789","Gene description":"Mitochondrial ribosomal protein S17","Uniprot":["Q9Y2R5"],"Chromosome":"7","Position":"55951877-55956500","Protein class":["Plasma proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein","RNA-binding","rRNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"7.4","Endometrial secretory cells":"8.4","Gastric chief cells":"16.4","Hepatocytes":"10.8","Late primary spermatocytes":"11.5","Mucous neck cells":"7.4","Parietal cells":"26.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"26.5","Spermatogenic cell types":"11.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"5268665.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047159"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":98,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047159":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.60e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.99e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"}},{"Gene":"MRPS21","Gene synonym":[],"Ensembl":"ENSG00000266472","Gene description":"Mitochondrial ribosomal protein S21","Uniprot":["P82921"],"Chromosome":"1","Position":"150293861-150308979","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"851.5","Gastric progenitor cells":"581.9","Late primary spermatocytes":"712.8","Late spermatids":"922.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"922.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA078289"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":30,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA078289":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - 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Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"143714036.7"},"Antibody":["HPA006083","HPA007830"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":79,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA006083":null,"HPA007830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.81e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.17e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"}},{"Gene":"MRPS24","Gene synonym":["HSPC335","MRP-S24"],"Ensembl":"ENSG00000062582","Gene description":"Mitochondrial ribosomal protein S24","Uniprot":["Q96EL2"],"Chromosome":"7","Position":"43866558-43869893","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"11.1","Brain excitatory neurons":"19.9","Brain inhibitory neurons":"17.7","Cholangiocytes":"9.2","Endometrial secretory cells":"13.3","Ependymal cells":"15.2","Hepatocytes":"19.2","Oligodendrocyte progenitor cells":"11.0","Oligodendrocytes":"14.9","Other brain neurons":"25.3","Parietal cells":"17.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"15.2","Gastric glandular cells":"17.7","Glial cells":"14.9","Hepatocytes":"19.2","Neuronal cells":"25.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"2557006.5","Microglia and Neuropil":"2141172.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA073947"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":127,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA073947":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.79e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.90e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.55e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.87e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.26e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"}},{"Gene":"MRPS25","Gene synonym":["DKFZp313H0817","FLJ00023","MRP-S25","RPMS25"],"Ensembl":"ENSG00000131368","Gene description":"Mitochondrial ribosomal protein S25","Uniprot":["P82663"],"Chromosome":"3","Position":"15009611-15065339","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"142.4","Epicardial cells":"216.0","Late spermatids":"141.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"216.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":108,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA043490":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":93,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018686":null,"HPA021149":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.82e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"}},{"Gene":"MRPS33","Gene synonym":["CGI-139"],"Ensembl":"ENSG00000090263","Gene description":"Mitochondrial ribosomal protein S33","Uniprot":["Q9Y291"],"Chromosome":"7","Position":"141002610-141015228","Protein class":["Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatocytes":"249.8","Late primary spermatocytes":"302.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"622428.6","Proximal tubules":"601616.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"17021991.2"},"Antibody":["HPA030425"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":45,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.62e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-6"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"}},{"Gene":"MRPS7","Gene synonym":["MRP-S","RP-S7","RPMS7"],"Ensembl":"ENSG00000125445","Gene description":"Mitochondrial ribosomal protein S7","Uniprot":["Q9Y2R9"],"Chromosome":"17","Position":"75261674-75266376","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"231.3","Esophageal suprabasal cells":"240.0","Late spermatids":"846.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"846.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"9026250.9"},"Antibody":["HPA022522","HPA023007"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":94,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA022522":null,"HPA023007":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.89e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.79e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.92e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"MRPS9","Gene synonym":["MRP-S9","RPMS9","S9mt"],"Ensembl":"ENSG00000135972","Gene description":"Mitochondrial ribosomal protein S9","Uniprot":["P82933"],"Chromosome":"2","Position":"105038069-105099960","Protein class":["Plasma proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"218.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"218.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"7001295.4","skeletal muscle":"7466142.9"},"Antibody":["HPA043476","HPA048479"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":111,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA043476":null,"HPA048479":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.04e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.91e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"}},{"Gene":"MRRF","Gene synonym":["RRF"],"Ensembl":"ENSG00000148187","Gene description":"Mitochondrial ribosome recycling factor","Uniprot":["Q96E11"],"Chromosome":"9","Position":"122264603-122331337","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"295.4","Late spermatids":"280.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"295.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047177","HPA049987"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":20,"Subcellular main location":["Microtubules","Cytokinetic bridge"],"Subcellular additional location":null,"Antibody RRID":{"HPA047177":null,"HPA049987":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.47e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":19,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA026446":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.01e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.74e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"}},{"Gene":"MS4A13","Gene synonym":[],"Ensembl":"ENSG00000204979","Gene description":"Membrane spanning 4-domains A13","Uniprot":["Q5J8X5"],"Chromosome":"11","Position":"60515392-60542721","Protein class":["Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"34","RNA tissue specific nTPM":{"testis":"3.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"10.0","Early spermatids":"22.3","Late primary spermatocytes":"38.9","Late spermatids":"89.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"89.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":52,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045017":null,"HPA063626":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MS4A14","Gene synonym":["DKFZp434H092","FLJ32856","MS4A16","NYD-SP21"],"Ensembl":"ENSG00000166928","Gene description":"Membrane spanning 4-domains A14","Uniprot":["Q96JA4"],"Chromosome":"11","Position":"60378530-60417756","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"69.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1200.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"36","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1200.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"26.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"5.5","non-classical monocyte":"8.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"monocytes":"8.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"1.0"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA058973":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MS4A18","Gene synonym":[],"Ensembl":"ENSG00000214782","Gene description":"Membrane spanning 4-domains A18","Uniprot":["Q3C1V0"],"Chromosome":"11","Position":"60724720-60745028","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"19","RNA tissue specific nTPM":{"breast":"5.6","intestine":"17.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"7.2","Enterocytes":"7.5","Late primary spermatocytes":"3.0","Late spermatids":"9.2","Parietal cells":"1.8","Prostatic glandular cells":"1.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Enterocytes":"7.5","Spermatogenic cell types":"9.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MSH4","Gene synonym":[],"Ensembl":"ENSG00000057468","Gene description":"MutS homolog 4","Uniprot":["O15457"],"Chromosome":"1","Position":"75796882-75913242","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Premature ovarian failure"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"1.7","testis":"4.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"23.7","Brain inhibitory neurons":"23.1","Early primary spermatocytes":"81.5","Late primary spermatocytes":"20.0","Myonuclei":"85.5","Papillary tip epithelial cells":"19.9","Retinal ganglion cells":"23.2","Retinal horizontal cells":"48.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"85.5","Neuronal cells":"48.1","Spermatogenic cell types":"81.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Equatorial segment","Flagellar centriole","Mid piece"],"Antibody RRID":{"HPA028117":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MSI1","Gene synonym":[],"Ensembl":"ENSG00000135097","Gene description":"Musashi RNA binding protein 1","Uniprot":["O43347"],"Chromosome":"12","Position":"120341330-120369164","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"retina":"96.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"45.0","Choroid plexus epithelial cells":"59.0","Cone photoreceptor cells":"99.4","Early spermatids":"73.4","Ependymal cells":"57.2","Late spermatids":"91.6","M\u00fcller glia":"135.4","Paneth cells":"46.4","Retinal pigment epithelial cells":"63.9","Rod photoreceptor cells":"186.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"135.4","Neuronal cells":"186.1","Pigment cells":"63.9","Spermatogenic cell types":"91.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"53.9","choroid plexus epithelial cell":"62.3","ependymal cell":"64.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"29.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"22.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":13,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA074923":null,"HPA075573":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"}},{"Gene":"MSMB","Gene synonym":["IGBF","MSP","MSPB","PN44","PRPS","PSP","PSP-94","PSP57","PSP94"],"Ensembl":"ENSG00000263639","Gene description":"Microseminoprotein beta","Uniprot":["P08118"],"Chromosome":"10","Position":"46033307-46048180","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"17","RNA tissue specific nTPM":{"prostate":"8771.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Prostatic glandular cells":"24515.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glandular cells":"24515.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"26","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"7341.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"18","RNA cell line specific nTPM":{"prostate cancer":"295.9"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB026357","HPA051257"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3100000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB026357":null,"HPA051257":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"}},{"Gene":"MSRA","Gene synonym":[],"Ensembl":"ENSG00000175806","Gene description":"Methionine sulfoxide reductase A","Uniprot":["Q9UJ68"],"Chromosome":"8","Position":"10054292-10428891","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"85.5","liver":"61.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"321.0","Bergmann glia":"499.2","Brain excitatory neurons":"929.3","Brain inhibitory neurons":"365.2","Choroid plexus epithelial cells":"316.1","Ependymal cells":"286.7","Late spermatids":"228.0","Oligodendrocyte progenitor cells":"371.9","Proximal tubule cells":"784.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"316.1","Glial cells":"499.2","Neuronal cells":"929.3","Renal nephron cells":"784.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"5.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"40000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":7,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA023804":null,"HPA053069":null,"HPA075766":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.73e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA005899":null,"HPA005914":null,"HPA006075":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.17e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"}},{"Gene":"MTA1","Gene synonym":[],"Ensembl":"ENSG00000182979","Gene description":"Metastasis associated 1","Uniprot":["Q13330"],"Chromosome":"14","Position":"105419820-105470729","Protein class":["Cancer-related genes","Disease related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"242.7","Epididymal principal cells":"369.8","Esophageal apical cells":"114.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"369.8","Secretory cells":"242.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":112,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB004508":null,"HPA005544":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.88e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"}},{"Gene":"MTCH2","Gene synonym":["SLC25A50"],"Ensembl":"ENSG00000109919","Gene description":"Mitochondrial carrier 2","Uniprot":["Q9Y6C9"],"Chromosome":"11","Position":"47617315-47642607","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"205.2","Early spermatids":"505.1","Gastric progenitor cells":"293.5","Hepatocytes":"201.1","Late primary spermatocytes":"725.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"293.5","Spermatogenic cell types":"725.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":81,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038390":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"MTF1","Gene synonym":[],"Ensembl":"ENSG00000188786","Gene description":"Metal regulatory transcription factor 1","Uniprot":["Q14872"],"Chromosome":"1","Position":"37809574-37859592","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"19.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophil progenitors":"235.7","Neutrophils":"795.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neutrophils":"795.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA028604":null,"HPA028689":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"}},{"Gene":"MTFR1","Gene synonym":["CHPPR","FAM54A2","KIAA0009"],"Ensembl":"ENSG00000066855","Gene description":"Mitochondrial fission regulator 1","Uniprot":["Q15390"],"Chromosome":"8","Position":"65644734-65771261","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cardiomyocytes":"3739.9","Late spermatids":"1346.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Myocytes":"3739.9","Spermatogenic cell types":"1346.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"602965.4","Granulosa cells":"533645.2","Oocytes":"162522.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3667","Protein tissue specific Intensity":{"kidney":"291084.5","liver":"442316.9"},"Antibody":["HPA023152","HPA056120"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":15,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023152":null,"HPA056120":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.63e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"}},{"Gene":"MTFR1L","Gene synonym":["FAM54B"],"Ensembl":"ENSG00000117640","Gene description":"Mitochondrial fission regulator 1 like","Uniprot":["Q9H019"],"Chromosome":"1","Position":"25818640-25832942","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"206.2","Late primary spermatocytes":"333.8","Late spermatids":"968.7","Platelets":"290.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Platelets":"290.2","Spermatogenic cell types":"968.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"14090432.5"},"Antibody":["HPA027124","HPA027130"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cell Junctions","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA027124":null,"HPA027130":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.00e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.94e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.31e-12"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"}},{"Gene":"MTFR2","Gene synonym":["DUFD1","FAM54A"],"Ensembl":"ENSG00000146410","Gene description":"Mitochondrial fission regulator 2","Uniprot":["Q6P444"],"Chromosome":"6","Position":"136231024-136250335","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"15.4","lymphoid tissue":"6.0","testis":"6.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Oocytes":"175.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Oocytes":"175.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"2.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2317","Protein cell type specific Intensity":{"Oocytes":"231737.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029792","HPA029794"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA029792":null,"HPA029794":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.84e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.44e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.34e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.34e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"MTHFSD","Gene synonym":["FLJ12998"],"Ensembl":"ENSG00000103248","Gene description":"Methenyltetrahydrofolate synthetase domain containing","Uniprot":["Q2M296"],"Chromosome":"16","Position":"86530178-86555235","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"4684540.1"},"Antibody":["HPA041333"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA041333":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.55e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"}},{"Gene":"MTIF3","Gene synonym":["IF-3mt","IF3(mt)"],"Ensembl":"ENSG00000122033","Gene description":"Mitochondrial translational initiation factor 3","Uniprot":["Q9H2K0"],"Chromosome":"13","Position":"27435643-27450591","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Initiation factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"634.2","Esophageal apical cells":"381.5","Late primary spermatocytes":"603.9","Oocytes":"773.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"773.7","Spermatogenic cell types":"634.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"8730578.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"624369.2"},"Antibody":["HPA039791"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":64,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA039791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.29e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"MTMR2","Gene synonym":["CMT4B","KIAA1073"],"Ensembl":"ENSG00000087053","Gene description":"Myotubularin related protein 2","Uniprot":["Q13614"],"Chromosome":"11","Position":"95821766-95925315","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"217.7","Oligodendrocytes":"258.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"6796992.1","Microglia and Neuropil":"5959675.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"10332699.6","Stomach":"3020038.3"},"Antibody":["HPA049831"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":28,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049831":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.93e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"}},{"Gene":"MTMR6","Gene synonym":[],"Ensembl":"ENSG00000139505","Gene description":"Myotubularin related protein 6","Uniprot":["Q9Y217"],"Chromosome":"13","Position":"25246222-25287510","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Endocytosis","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"148.2","Neutrophils":"342.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"342.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.14e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"MTNR1A","Gene synonym":["MEL-1A-R"],"Ensembl":"ENSG00000168412","Gene description":"Melatonin receptor 1A","Uniprot":["P48039"],"Chromosome":"4","Position":"186526792-186555567","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"1.7"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.2"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":26,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MTNR1B","Gene synonym":[],"Ensembl":"ENSG00000134640","Gene description":"Melatonin receptor 1B","Uniprot":["P49286"],"Chromosome":"11","Position":"92969651-92985066","Protein class":["FDA approved drug targets","G-protein coupled receptors","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"1.6","Ependymal cells":"2.3","Syncytiotrophoblasts":"6.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2.3","Neuronal cells":"1.6","Trophoblast cells":"6.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"3.5","medium spiny neuron":"2.1","midbrain-derived inhibitory":"5.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"3.8","testis cancer":"1.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA074024":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MTO1","Gene synonym":[],"Ensembl":"ENSG00000135297","Gene description":"Mitochondrial tRNA translation optimization 1","Uniprot":["Q9Y2Z2"],"Chromosome":"6","Position":"73461578-73509236","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":null,"Disease involvement":["Cardiomyopathy","Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"173.3","Late primary spermatocytes":"109.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"173.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA030230":null,"HPA030232":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"}},{"Gene":"MTOR","Gene synonym":["FLJ44809","FRAP","FRAP1","FRAP2","RAFT1","RAPT1"],"Ensembl":"ENSG00000198793","Gene description":"Mechanistic target of rapamycin kinase","Uniprot":["P42345"],"Chromosome":"1","Position":"11106535-11262556","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Essential proteins","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes","Disease variant","Epilepsy","FDA approved drug targets","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":150,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB069425":null,"CAB080053":null,"CAB080065":null,"CAB080070":null,"CAB080081":null,"CAB080095":null,"CAB080096":null,"CAB080097":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"}},{"Gene":"MTPAP","Gene synonym":["FLJ10486","PAPD1","SPAX4","TENT6"],"Ensembl":"ENSG00000107951","Gene description":"Mitochondrial poly(A) polymerase","Uniprot":["Q9NVV4"],"Chromosome":"10","Position":"30309801-30374448","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["mRNA processing","Transcription"],"Molecular function":["Nucleotidyltransferase","RNA-binding","Transferase"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"34.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"195.0","Late primary spermatocytes":"108.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"195.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"173068.8","lymphoid tissue":"96513.4"},"Antibody":["HPA038620","HPA058232"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":36,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA038620":null,"HPA058232":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.79e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.94e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"}},{"Gene":"MTRF1L","Gene synonym":["HMRF1L","mtRF1a"],"Ensembl":"ENSG00000112031","Gene description":"Mitochondrial translation release factor 1 like","Uniprot":["Q9UGC7"],"Chromosome":"6","Position":"152987362-153002709","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"74.4","Late spermatids":"75.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"1173234.1","Distal tubules":"438125.8","Large ducts":"533461.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036367"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036367":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.74e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.93e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.13e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.61e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"}},{"Gene":"MTRFR","Gene synonym":["C12orf65","COXPD7","FLJ38663","mtRF-R","SPG55"],"Ensembl":"ENSG00000130921","Gene description":"Mitochondrial translation release factor in rescue","Uniprot":["Q9H3J6"],"Chromosome":"12","Position":"123233385-123258079","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"55.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"140.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"2120414.8"},"Antibody":["HPA057595"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":4,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA057595":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.05e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.35e-5"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"MTTP","Gene synonym":["ABL","MTP"],"Ensembl":"ENSG00000138823","Gene description":"Microsomal triglyceride transfer protein","Uniprot":["P55157"],"Chromosome":"4","Position":"99564081-99623997","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"intestine":"259.2","liver":"249.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Enterocytes":"775.0","Hepatocytes":"326.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Enterocytes":"775.0","Hepatocytes":"326.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"astrocyte":"14.8","Bergmann glia":"9.2","ependymal cell":"30.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"49.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Gastric cancer":"5.1","liver cancer":"18.2"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"556825071.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"148622559.3","liver":"394438716.7"},"Antibody":["HPA051170","HPA054862"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"730000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":3,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA051170":null,"HPA054862":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MTX1","Gene synonym":["MTX","MTXN"],"Ensembl":"ENSG00000173171","Gene description":"Metaxin 1","Uniprot":["Q13505"],"Chromosome":"1","Position":"155208695-155213824","Protein class":["Predicted membrane proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"8.1","Cardiomyocytes":"19.4","Epicardial cells":"38.7","Kupffer cells":"8.2","Late spermatids":"11.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"38.7","Myocytes":"19.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"3.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"45363600.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"29653995.4"},"Antibody":["HPA011543"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":8,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA011543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"}},{"Gene":"MTX2","Gene synonym":[],"Ensembl":"ENSG00000128654","Gene description":"Metaxin 2","Uniprot":["O75431"],"Chromosome":"2","Position":"176269395-176338025","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Osteoporosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"43643493.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"40917260.4"},"Antibody":["HPA031550","HPA031551","HPA031552"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":47,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA031550":null,"HPA031551":null,"HPA031552":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.09e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"}},{"Gene":"MUC1","Gene synonym":["ADMCKD","ADMCKD1","Ca15-3","CD227","EMA","KL-6","MCD","MCKD","MCKD1","PEM","PUM"],"Ensembl":"ENSG00000185499","Gene description":"Mucin 1, cell surface associated","Uniprot":["P15941"],"Chromosome":"1","Position":"155185824-155192916","Protein class":["Cancer-related genes","CD markers","Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"416.9","stomach 1":"998.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"192.9","Alveolar cells type 2":"236.0","Breast lactating cells":"217.7","Conjunctival goblet cells":"94.2","Endometrial luminal cells":"102.3","Endometrial secretory cells":"154.6","Foveolar cells":"271.9","Gastric chief cells":"137.6","Mucous neck cells":"117.1","Prostatic club cells":"93.2","Respiratory deuterosomal cells":"126.5","Salivary duct cells":"75.7","Transitional alveolar cells":"176.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"236.0","Ciliated cells":"126.5","Gastric glandular cells":"271.9","Secretory cells":"217.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"1.2"},"RNA blood lineage specificity":"Lineage enhanced","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":{"T-cells":"1.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"211.1","pancreatic cancer":"218.2"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"10612191.2","Pancreas epithelial cells":"11168905.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"28224697.1"},"Antibody":["CAB000036","CAB001986","HPA004179","HPA007235","HPA008855","CAB080102","CAB080103"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":"Secreted in other tissues","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2100000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 68: Foveolar cells - Mucosal defense","Interactions":29,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB000036":null,"CAB001986":null,"CAB080102":null,"CAB080103":null,"HPA004179":null,"HPA007235":null,"HPA008855":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.45e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.35e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.90e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"}},{"Gene":"MUC15","Gene synonym":[],"Ensembl":"ENSG00000169550","Gene description":"Mucin 15, cell surface associated","Uniprot":["Q8N387"],"Chromosome":"11","Position":"26559032-26572263","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"26","RNA tissue specific nTPM":{"epididymis":"1841.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Epididymal principal cells":"5404.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"5404.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"3.7","medium spiny neuron":"4.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"85.1"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"basal ganglia":"10.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"11.0"},"RNA tissue cell type enrichment":["Kidney - Ascending Loop of Henle cells","Prostate - Prostate basal glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"cerebellum":"1.2","thalamus":"1.4"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"900005.6","salivary gland":"1463014.7"},"Antibody":["HPA026110","HPA073304"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026110":null,"HPA073304":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"}},{"Gene":"MUC16","Gene synonym":["CA-125","CA125","FLJ14303"],"Ensembl":"ENSG00000181143","Gene description":"Mucin 16, cell surface associated","Uniprot":["Q8WXI7"],"Chromosome":"19","Position":"8848844-8981342","Protein class":["Plasma proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"adipose tissue":"6.5","cervix":"15.0","fallopian tube":"5.5","salivary gland":"5.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"953.4","Endometrial ciliated cells":"234.4","Endometrial glandular cells":"474.1","Endometrial secretory cells":"428.8","Epicardial cells":"1309.9","Mesothelial cells":"376.1","Ocular epithelial cells":"330.9","Respiratory ciliated cells":"237.8","Respiratory deuterosomal cells":"634.4","Respiratory secretory cells":"435.6","Salivary duct cells":"460.6","Salivary ionocytes":"746.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1309.9","Ciliated cells":"634.4","Ductal cells":"460.6","Glandular cells":"474.1","Goblet cells":"953.4","Ionocytes":"746.2","Secretory cells":"435.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"34.9","Ovary Serous Cystadenocarcinoma (TCGA)":"98.0","Uterine Corpus Endometrial Carcinoma (TCGA)":"35.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"ovarian cancer":"15.7"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"140000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB055172":null,"CAB080360":null,"HPA065600":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.37e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.63e-5"},"Cancer prognostics - 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Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":null,"Protein cell type distribution":null,"Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":null,"Protein tissue distribution":null,"Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MUC4","Gene synonym":[],"Ensembl":"ENSG00000145113","Gene description":"Mucin 4, cell surface associated","Uniprot":["Q99102"],"Chromosome":"3","Position":"195746765-195811973","Protein class":["Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"18.5","intestine":"31.2","prostate":"14.6","vagina":"14.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"4.9","Conjunctival goblet cells":"5.8","Endometrial secretory cells":"8.1","Loop of henle epithelial cells":"4.9","Papillary tip epithelial cells":"42.3","Prostatic club cells":"6.7","Prostatic hillock cells":"8.9","Renal collecting duct intercalated cells":"11.5","Renal collecting duct principal cells":"9.6","Respiratory deuterosomal cells":"9.3","Salivary duct cells":"14.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"8.9","Ciliated cells":"9.3","Ductal cells":"14.1","Renal nephron cells":"42.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"3.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"3.4","head and neck cancer":"4.1","pancreatic cancer":"3.1"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB013536":null,"HPA005895":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MVK","Gene synonym":["LRBP","MK"],"Ensembl":"ENSG00000110921","Gene description":"Mevalonate kinase","Uniprot":["Q03426"],"Chromosome":"12","Position":"109573255-109598125","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cholesterol biosynthesis","Cholesterol metabolism","Lipid biosynthesis","Lipid metabolism","Steroid biosynthesis","Steroid metabolism","Sterol biosynthesis","Sterol metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"58.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"74.8","Cardiomyocytes":"72.6","Early spermatids":"83.9","Esophageal apical cells":"202.5","Esophageal suprabasal cells":"79.1","Late primary spermatocytes":"68.3","Retinal horizontal cells":"74.1","Syncytiotrophoblasts":"71.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"202.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"41.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary gland basal cells","Pituitary gland - Corticotropes","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"23382910.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"26495077.6"},"Antibody":["HPA016961","HPA044110"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":11,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA016961":null,"HPA044110":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"}},{"Gene":"MXD1","Gene synonym":["bHLHc58","MAD","MAD1"],"Ensembl":"ENSG00000059728","Gene description":"MAX dimerization protein 1","Uniprot":["Q05195"],"Chromosome":"2","Position":"69897688-69942945","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"163.8","esophagus":"125.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Esophageal apical cells":"5212.2","Neutrophils":"4650.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"5212.2","Neutrophils":"4650.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"neutrophil":"498.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"49","RNA blood lineage specific nTPM":{"granulocytes":"498.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Neutrophils","Spleen - Neutrophils_2","Stomach - Gastric mucous cells","Testis - Early spermatids","Thyroid gland - Neutrophils"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"751","Protein cell type specific Intensity":{"Neutrophils":"75084.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001599"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":9,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.42e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"}},{"Gene":"MYBL1","Gene synonym":["A-myb","AMYB"],"Ensembl":"ENSG00000185697","Gene description":"MYB proto-oncogene like 1","Uniprot":["P10243"],"Chromosome":"8","Position":"66562175-66614247","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"18.8","testis":"11.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"61.9","Early primary spermatocytes":"49.4","Innate lymphoid cells":"57.5","NK-cells":"260.0","T-cells":"171.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"NK-cells":"260.0","T-cells":"171.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"19","RNA single nuclei brain specific nCPM":{"leukocyte":"367.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"1.9","MAIT T-cell":"1.3"},"RNA blood lineage specificity":"Lineage enhanced","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":{"T-cells":"1.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"123.9"},"RNA tissue cell type enrichment":["Adipose visceral - T-cells","Liver - NK-cells (Liver)","Lung - NK-cells (Lung)","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008791"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA008791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"}},{"Gene":"MYBPC1","Gene synonym":["ssMyBP-C"],"Ensembl":"ENSG00000196091","Gene description":"Myosin binding protein C1","Uniprot":["Q00872"],"Chromosome":"12","Position":"101568353-101686028","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Actin-binding","Muscle protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"85","RNA tissue specific nTPM":{"skeletal muscle":"10574.4","tongue":"4864.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Myonuclei":"14831.0","Thymic myoid cells":"5551.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Myocytes":"14831.0","Stromal cells":"5551.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"astrocyte":"136.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"94.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"28","RNA cell line specific nTPM":{"Gastric cancer":"6.1","prostate cancer":"9.0"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Prostate - Prostate glandular cells","Skeletal muscle - Skeletal myocytes","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"9","RNA mouse brain regional specific nTPM":{"cerebellum":"39.6","olfactory bulb":"10.6"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":"2","Protein cell type specific Intensity":{"Skeletal myofibers":"16870166028.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"4","Protein tissue specific Intensity":{"skeletal muscle":"3460292330.4"},"Antibody":["HPA021004","HPA027614"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"210000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021004":null,"HPA027614":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.60e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MYCBP","Gene synonym":["AMY-1"],"Ensembl":"ENSG00000214114","Gene description":"MYC binding protein","Uniprot":["Q99417"],"Chromosome":"1","Position":"38862493-38873368","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"51.4","Endometrial ciliated cells":"24.7","Fallopian tube ciliated cells":"32.4","Late primary spermatocytes":"17.2","Megakaryocytes":"24.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"32.4","Megakaryocytes":"24.7","Spermatogenic cell types":"51.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"11.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"47344021.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"133642877.5"},"Antibody":["HPA041188","HPA078331"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA041188":null,"HPA078331":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.51e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"}},{"Gene":"MYCBPAP","Gene synonym":["AMAP-1","DKFZp434N1415"],"Ensembl":"ENSG00000136449","Gene description":"MYCBP associated protein","Uniprot":["Q8TBZ2"],"Chromosome":"17","Position":"50508425-50531501","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"61.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"38.7","Early spermatids":"256.5","Ependymal cells":"54.2","Fallopian tube ciliated cells":"40.2","Late primary spermatocytes":"233.1","Late spermatids":"201.8","Respiratory ciliated cells":"87.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Ciliated cells":"87.1","Spermatogenic cell types":"256.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"56.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"39080","Protein cell type specific Intensity":{"Fallopian tube cells":"3907973.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4194","Protein tissue specific Intensity":{"fallopian tube":"419427.8"},"Antibody":["HPA023257"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":14,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA023257":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.00e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"MYG1","Gene synonym":["C12orf10","Gamm1","MYG"],"Ensembl":"ENSG00000139637","Gene description":"MYG1 exonuclease","Uniprot":["Q9HB07"],"Chromosome":"12","Position":"53299695-53307177","Protein class":["Disease related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"7.7","Bergmann glia":"8.7","Brain excitatory neurons":"16.0","Brain inhibitory neurons":"14.3","Ependymal cells":"11.9","Late spermatids":"8.5","Oligodendrocytes":"11.6","Other brain neurons":"26.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"11.9","Glial cells":"11.6","Neuronal cells":"26.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":37,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038626":null,"HPA038627":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-3"}},{"Gene":"MYH1","Gene synonym":["MGC133384","MYHa","MyHC-2X\/D","MYHSA1"],"Ensembl":"ENSG00000109061","Gene description":"Myosin heavy chain 1","Uniprot":["P12882"],"Chromosome":"17","Position":"10492307-10518542","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Hearing"],"Molecular function":["Actin-binding","Calmodulin-binding","Motor protein","Muscle protein","Myosin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"137","RNA tissue specific nTPM":{"skeletal muscle":"7384.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"24","RNA single cell type specific nCPM":{"Myonuclei":"706.2","Thymic myoid cells":"186.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Myocytes":"706.2","Stromal cells":"186.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"44","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"13.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"8757559901.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"4280997888.5"},"Antibody":["HPA001349","CAB010759"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Focal adhesion sites"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":null,"Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":11,"Subcellular main location":["Focal adhesion sites"],"Subcellular additional location":null,"Antibody RRID":{"CAB010759":null,"HPA001349":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MYH15","Gene synonym":["KIAA1000"],"Ensembl":"ENSG00000144821","Gene description":"Myosin heavy chain 15","Uniprot":["Q9Y2K3"],"Chromosome":"3","Position":"108380368-108529322","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding","Calmodulin-binding","Motor protein","Muscle protein","Myosin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"3.0","tongue":"1.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"42.5","Alveolar cells type 1":"13.6","Astrocytes":"26.7","Bergmann glia":"38.1","Cone photoreceptor cells":"16.6","Ependymal cells":"14.6","M\u00fcller glia":"18.9","Oligodendrocytes":"14.2","Oocytes":"13.8","Rod photoreceptor cells":"14.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"42.5","Glial cells":"38.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"30.6","Bergmann glia":"35.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"9.4"},"RNA tissue cell type enrichment":["Pituitary gland - Thyrotropes","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"967","Protein cell type specific Intensity":{"Oocytes":"96739.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3713","Protein tissue specific Intensity":{"lung":"371254.7"},"Antibody":["HPA034871","HPA057915"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA034871":null,"HPA057915":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MYNN","Gene synonym":["SBBIZ1","ZBTB31","ZNF902"],"Ensembl":"ENSG00000085274","Gene description":"Myoneurin","Uniprot":["Q9NPC7"],"Chromosome":"3","Position":"169773396-169789716","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"11248","Protein cell type specific Intensity":{"Distal tubules":"1124838.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045149"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA045149":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.29e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"}},{"Gene":"MYO15A","Gene synonym":["DFNB3","MYO15"],"Ensembl":"ENSG00000091536","Gene description":"Myosin XVA","Uniprot":["Q9UKN7"],"Chromosome":"17","Position":"18108756-18179802","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Hearing"],"Molecular function":["Actin-binding","Calmodulin-binding","Motor protein","Myosin"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"pituitary gland":"40.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"115.9","Gonadotrophs":"39.7","Lactotrophs":"88.9","Late spermatids":"95.5","Somatotrophs":"545.6","Thyrotrophs":"201.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"545.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"1.3"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"790","Protein tissue specific Intensity":{"lymphoid tissue":"78954.0"},"Antibody":["HPA078501"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 20: Pituitary gland - Hormone signaling","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA078501":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MYO16","Gene synonym":["KIAA0865","Myo16b","MYR8","NYAP3","PPP1R107"],"Ensembl":"ENSG00000041515","Gene description":"Myosin XVI","Uniprot":["Q9Y6X6"],"Chromosome":"13","Position":"108596152-109208005","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding","Motor protein","Myosin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.6","pituitary gland":"2.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Pituicytes\/FSCs":"2064.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Glial cells":"2064.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"917.0","LAMP5-LHX6 and Chandelier":"1314.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"1.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"72.6"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"60","Protein cell type specific Intensity":{"Microglia and Neuropil":"6032.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040110","HPA058769","HPA071948"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA040110":null,"HPA058769":null,"HPA071948":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"MYO18B","Gene synonym":["BK125H2.1"],"Ensembl":"ENSG00000133454","Gene description":"Myosin XVIIIB","Uniprot":["Q8IUG5"],"Chromosome":"22","Position":"25742144-26031045","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding","Motor protein","Myosin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"114.3","skeletal muscle":"251.6","tongue":"51.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cardiomyocytes":"732.2","Myonuclei":"1232.2","Myosatellite cells":"414.9","Thymic myoid cells":"333.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"1232.2","Stem cells":"414.9","Stromal cells":"333.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"thalamic excitatory":"15.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"1.8"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"midbrain":"1.8","thalamus":"5.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"11.3","Sarcoma":"6.8"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"5792926.1","Cardiomyocytes":"8994388.2","Skeletal myofibers":"13720079.5","Smooth muscle cells":"3838693.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"18493","Protein tissue specific Intensity":{"heart muscle":"1168480.9","skeletal muscle":"2530074.9"},"Antibody":["HPA000953"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA000953":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Colon enterocytes","Pancreas - Ductal cells","Pituitary gland - Gonadotropes","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"38259930.1"},"Antibody":["HPA053490"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA053490":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":1,"Subcellular main location":["Actin filaments","Cytoplasmic bodies"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA051893":null,"HPA075413":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045483":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"MYO5B","Gene synonym":["KIAA1119"],"Ensembl":"ENSG00000167306","Gene description":"Myosin VB","Uniprot":["Q9ULV0"],"Chromosome":"18","Position":"49822789-50195164","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Actin-binding","Calmodulin-binding","Motor protein","Myosin"],"Disease involvement":["Disease variant","Intrahepatic cholestasis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"58.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"584.1","Endometrial luminal cells":"340.2","Esophageal apical cells":"446.2","Ocular epithelial cells":"714.1","Salivary acinar cells":"666.2","Urothelial cells":"454.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"666.2","Barrier epithelial cells":"714.1","Glandular cells":"584.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"168.5","mammillary body":"375.0","MGE interneuron":"209.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":14,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA040593":null,"HPA040902":null,"HPA069773":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.87e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.22e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"MYO9A","Gene synonym":["FLJ11061","FLJ13244","MGC71859"],"Ensembl":"ENSG00000066933","Gene description":"Myosin IXA","Uniprot":["B2RTY4"],"Chromosome":"15","Position":"71822291-72118577","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding","GTPase activation","Motor protein","Myosin"],"Disease involvement":["Congenital myasthenic syndrome","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"57.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Loop of henle epithelial cells":"761.8","Rod photoreceptor cells":"1298.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"1298.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"1454647.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"2178828.2"},"Antibody":["HPA039812","HPA040071"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA039812":null,"HPA040071":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.34e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"}},{"Gene":"MYOCOS","Gene synonym":[],"Ensembl":"ENSG00000283683","Gene description":"Myocilin opposite strand","Uniprot":["A0A1B0GUC4"],"Chromosome":"1","Position":"171600621-171638799","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"5.0","epididymis":"3.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"26.5","Endometrial ciliated cells":"29.0","Endometrial glandular cells":"14.6","Oocytes":"96.7","Proximal tubule cells":"39.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"29.0","Oocytes":"96.7","Renal nephron cells":"39.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"26.5","Uterine Corpus Endometrial Carcinoma (TCGA)":"17.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"4.1"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1011","Protein cell type specific Intensity":{"Oocytes":"101081.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"}},{"Gene":"MYPOP","Gene synonym":["P42pop"],"Ensembl":"ENSG00000176182","Gene description":"Myb related transcription factor, partner of profilin","Uniprot":["Q86VE0"],"Chromosome":"19","Position":"45890023-45902613","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA065307":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.54e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"}},{"Gene":"NAA11","Gene synonym":["ARD1B","ARD2","hARD2"],"Ensembl":"ENSG00000156269","Gene description":"N-alpha-acetyltransferase 11, NatA catalytic subunit","Uniprot":["Q9BSU3"],"Chromosome":"4","Position":"79225694-79326061","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"placenta":"3.9","testis":"5.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"26.0","Cardiomyocytes":"25.8","Cytotrophoblasts":"56.0","Differentiating spermatogonia":"21.9","Early primary spermatocytes":"42.0","Early spermatids":"43.8","Ependymal cells":"36.1","Epicardial cells":"52.3","Extravillous trophoblasts":"29.2","Fibro-adipogenic progenitors":"43.6","Fibroblasts":"30.9","Late primary spermatocytes":"67.6","Late spermatids":"40.4","Migrating cytotrophoblasts":"35.6","Syncytiotrophoblasts":"31.9","Undifferentiated spermatogonia":"26.0","Vascular smooth muscle cells":"33.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"52.3","Ciliated cells":"36.1","Fibro-adipogenic progenitors":"43.6","Mural cells":"33.9","Spermatogenic cell types":"67.6","Trophoblast cells":"56.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"astrocyte":"81.9","ependymal cell":"71.2","fibroblast":"42.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"1.2","Testicular Germ Cell Tumor (TCGA)":"4.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"7.0","thyroid cancer":"7.2"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"730644.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"39","Protein tissue specific Intensity":{"lymphoid tissue":"3863.7"},"Antibody":["HPA035922"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus","Primary cilium","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":15,"Subcellular main location":["Golgi apparatus","Centrosome","Cytosol"],"Subcellular additional location":["Nucleoplasm","Primary cilium","Basal body"],"Antibody RRID":{"HPA035922":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NAA20","Gene synonym":["dJ1002M8.1","NAT3","NAT5"],"Ensembl":"ENSG00000173418","Gene description":"N-alpha-acetyltransferase 20, NatB catalytic subunit","Uniprot":["P61599"],"Chromosome":"20","Position":"20017310-20033655","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1708.5","Esophageal basal cells":"394.4","Esophageal suprabasal cells":"780.6","Hofbauer cells":"430.5","Late primary spermatocytes":"858.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1708.5","Spermatogenic cell types":"858.2","Suprabasal cells":"780.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"8193452.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"6214701.4","lymphoid tissue":"4519640.8"},"Antibody":["HPA063344"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA063344":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"}},{"Gene":"NAA80","Gene synonym":["FUS2","NAT6"],"Ensembl":"ENSG00000243477","Gene description":"N-alpha-acetyltransferase 80, NatH catalytic subunit","Uniprot":["Q93015"],"Chromosome":"3","Position":"50296402-50299416","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Deafness","Disease variant","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"59.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1.9","Late spermatids":"7.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"7.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"eosinophil":"56.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"56.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039576":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"}},{"Gene":"NAALADL1","Gene synonym":["HILAP"],"Ensembl":"ENSG00000168060","Gene description":"N-acetylated alpha-linked acidic dipeptidase like 1","Uniprot":["Q9UQQ1"],"Chromosome":"11","Position":"65044818-65058553","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Aminopeptidase","Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"intestine":"96.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"24","RNA single cell type specific nCPM":{"Enterocytes":"610.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Enterocytes":"610.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"9.2","leukocyte":"6.2","pericyte":"6.6","vascular associated smooth muscle cell":"5.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"183.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Endothelial cells","Liver - Vascular endothelial cells","Prostate - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"201095","Protein tissue specific Intensity":{"intestine":"20109546.1"},"Antibody":["HPA047123"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA047123":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"}},{"Gene":"NAALADL2","Gene synonym":[],"Ensembl":"ENSG00000177694","Gene description":"N-acetylated alpha-linked acidic dipeptidase like 2","Uniprot":["Q58DX5"],"Chromosome":"3","Position":"174438573-175810548","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"1264.6","Renal connecting tubule cells":"1615.5","Salivary acinar cells":"1320.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"1615.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"10.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"4.9"},"RNA tissue cell type enrichment":["Breast - Breast myoepithelial cells","Kidney - Fibroblasts","Liver - Hepatocytes","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"872899.4","Collecting ducts":"960969.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"10746564.2"},"Antibody":["HPA012413","HPA017425","CAB025586"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB025586":null,"HPA012413":null,"HPA017425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.88e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.63e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"}},{"Gene":"NABP1","Gene synonym":["DKFZp667M1322","FLJ13624","FLJ22833","hSSB2","MGC111163","NABP1-OT1","OBFC2A","SOSS-B2","SSB2"],"Ensembl":"ENSG00000173559","Gene description":"Nucleic acid binding protein 1","Uniprot":["Q96AH0"],"Chromosome":"2","Position":"191678068-191741097","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"2644.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"2644.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"115.3","leukocyte":"145.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Neutrophils","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"346117.5","T-cells":"224786.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5836","Protein tissue specific Intensity":{"lymphoid tissue":"583601.6"},"Antibody":["HPA054978","HPA067802"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA054978":null,"HPA067802":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.86e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"}},{"Gene":"NABP2","Gene synonym":["hSSB1","MGC2731","OBFC2B","SOSS-B1","SSB1"],"Ensembl":"ENSG00000139579","Gene description":"Nucleic acid binding protein 2","Uniprot":["Q9BQ15"],"Chromosome":"12","Position":"56222015-56229854","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"428.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"428.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"214356.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"45","Protein tissue specific Intensity":{"fallopian tube":"2537.6","kidney":"6481.9"},"Antibody":["HPA044615","HPA057213"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":21,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044615":null,"HPA057213":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.70e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.91e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"}},{"Gene":"NACA2","Gene synonym":["MGC71999","NACAL"],"Ensembl":"ENSG00000253506","Gene description":"Nascent polypeptide associated complex subunit alpha 2","Uniprot":["Q9H009"],"Chromosome":"17","Position":"61590421-61591219","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"29","RNA tissue specific nTPM":{"testis":"59.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"15","RNA single cell type specific nCPM":{"Early spermatids":"371.3","Late primary spermatocytes":"658.0","Late spermatids":"167.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"48","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"658.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"413","Protein cell type specific Intensity":{"Neutrophils":"41311.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"639","Protein tissue specific Intensity":{"blood vessel":"63898.1"},"Antibody":["HPA073152","HPA073648"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA073152":null,"HPA073648":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NADK2","Gene synonym":["C5orf33","FLJ30596","MNADK","NADKD1"],"Ensembl":"ENSG00000152620","Gene description":"NAD kinase 2, mitochondrial","Uniprot":["Q4G0N4"],"Chromosome":"5","Position":"36192589-36242279","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"liver":"306.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"146.0","Early spermatids":"336.6","Ependymal cells":"192.6","Hepatocytes":"293.9","Late primary spermatocytes":"237.4","Late spermatids":"213.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"192.6","Hepatocytes":"293.9","Spermatogenic cell types":"336.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"205.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"290029872.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"203811842.1"},"Antibody":["HPA038366","HPA038367","HPA061492"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"31000","Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038366":null,"HPA038367":null,"HPA061492":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"}},{"Gene":"NAF1","Gene synonym":[],"Ensembl":"ENSG00000145414","Gene description":"Nuclear assembly factor 1 ribonucleoprotein","Uniprot":["Q96HR8"],"Chromosome":"4","Position":"163110073-163166890","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis","rRNA processing"],"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"159.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036241":null,"HPA036242":null,"HPA066090":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.50e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.07e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.29e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.46e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"NAGK","Gene synonym":["GNK"],"Ensembl":"ENSG00000124357","Gene description":"N-acetylglucosamine kinase","Uniprot":["Q9UJ70"],"Chromosome":"2","Position":"71064344-71079808","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"458.9","Esophageal suprabasal cells":"293.8","Hofbauer cells":"227.0","Late primary spermatocytes":"180.1","Syncytiotrophoblasts":"342.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"458.9","Suprabasal cells":"293.8","Trophoblast cells":"342.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"392.0","granulocytes":"289.2","monocytes":"594.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"313025799.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035206","HPA035207"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"640000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":31,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035206":null,"HPA035207":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"}},{"Gene":"NAGS","Gene synonym":["AGAS","ARGA","NAT7"],"Ensembl":"ENSG00000161653","Gene description":"N-acetylglutamate synthase","Uniprot":["Q8N159"],"Chromosome":"17","Position":"44004622-44009068","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Urea cycle"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"intestine":"14.9","liver":"49.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"9.8","Enterocytes":"43.2","Epididymal efferent duct absorptive cells":"15.9","Epididymal principal cells":"13.5","Esophageal apical cells":"15.7","Hepatocytes":"23.8","Late primary spermatocytes":"23.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"43.2","Hepatocytes":"23.8","Spermatogenic cell types":"23.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"endothelial cell":"6.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"18.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"23055965.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"91796","Protein tissue specific Intensity":{"liver":"9179593.1"},"Antibody":["HPA027300"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA027300":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.60e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.23e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.90e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.35e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"}},{"Gene":"NAP1L4","Gene synonym":["NAP2"],"Ensembl":"ENSG00000205531","Gene description":"Nucleosome assembly protein 1 like 4","Uniprot":["Q99733"],"Chromosome":"11","Position":"2944431-2992377","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"378.9","Distal convoluted tubule cells":"239.4","Renal collecting duct intercalated cells":"213.8","Renal connecting tubule cells":"188.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"378.9","Renal nephron cells":"239.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB011567"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3800000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB011567":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.13e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.65e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.46e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"}},{"Gene":"NAPRT","Gene synonym":["NAPRT1","PP3856"],"Ensembl":"ENSG00000147813","Gene description":"Nicotinate phosphoribosyltransferase","Uniprot":["Q6XQN6"],"Chromosome":"8","Position":"143574785-143578649","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Pyridine nucleotide biosynthesis"],"Molecular function":["Ligase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"103.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"246.9","Enteric transient amplifying cells":"152.2","Enterocytes":"505.0","Esophageal apical cells":"900.8","Esophageal suprabasal cells":"158.6","Foveolar cells":"154.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"900.8","Enterocytes":"505.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"195221437.0","Proximal tubules":"158132071.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"151801080.4"},"Antibody":["HPA023739","HPA024017","CAB068206","CAB068207"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2400000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"CAB068206":null,"CAB068207":null,"HPA023739":null,"HPA024017":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.67e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.62e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"}},{"Gene":"NAPSA","Gene synonym":["KAP","Kdap","NAP1","NAPA"],"Ensembl":"ENSG00000131400","Gene description":"Napsin A aspartic peptidase","Uniprot":["O96009"],"Chromosome":"19","Position":"50358472-50365830","Protein class":["Enzymes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Aspartyl protease","Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"lung":"983.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Alveolar cells type 1":"1828.9","Alveolar cells type 2":"5089.1","Transitional alveolar cells":"1533.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Alveolar cells":"5089.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"1859.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"memory B-cell":"2.8","plasmacytoid DC":"4.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"B-cells":"2.8","dendritic cells":"4.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"13.4","lymphoma":"19.4","ovarian cancer":"32.3"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"45000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB009591":null,"HPA045280":null,"HPA047236":null,"HPA047744":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":19,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nuclear membrane","Nucleoli"],"Antibody RRID":{"HPA036817":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.83e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"}},{"Gene":"NBPF20","Gene synonym":[],"Ensembl":"ENSG00000162825","Gene description":"NBPF member 20","Uniprot":[],"Chromosome":"1","Position":"145289900-145425603","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatocytes":"40.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"40.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 18: Adrenal cortex cells - Steroidogensis","Interactions":null,"Subcellular main location":["Primary cilium","Cytosol"],"Subcellular additional location":["Golgi apparatus","Vesicles","Microtubules","Cytokinetic bridge","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA042595":null,"HPA043105":null,"HPA043692":null,"HPA044023":null,"HPA046971":null,"HPA058050":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.46e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"}},{"Gene":"NBPF3","Gene synonym":["AE2"],"Ensembl":"ENSG00000142794","Gene description":"NBPF member 3","Uniprot":["Q9H094"],"Chromosome":"1","Position":"21440128-21485005","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"9.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"98.6","Early primary spermatocytes":"46.0","Leydig cells":"44.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"98.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045044":null,"HPA046411":null,"HPA047447":null,"HPA058050":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NBPF6","Gene synonym":[],"Ensembl":"ENSG00000186086","Gene description":"NBPF member 6","Uniprot":["Q5VWK0"],"Chromosome":"1","Position":"108450282-108471920","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"2.6","testis":"2.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"2.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"3.6"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"basal ganglia":"4.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045044":null,"HPA046411":null,"HPA047447":null,"HPA058050":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NBR1","Gene synonym":["1A1-3B","CA125","KIAA0049","M17S2"],"Ensembl":"ENSG00000188554","Gene description":"NBR1 autophagy cargo receptor","Uniprot":["Q14596"],"Chromosome":"17","Position":"43170481-43211689","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1686.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1686.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":52,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA022944":null,"HPA022999":null,"HPA023999":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.59e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.35e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.02e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"}},{"Gene":"NCAPH","Gene synonym":["BRRN1","CAP-H","hCAP-H"],"Ensembl":"ENSG00000121152","Gene description":"Non-SMC condensin I complex subunit H","Uniprot":["Q15003"],"Chromosome":"2","Position":"96335766-96377091","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA condensation","Mitosis"],"Molecular function":null,"Disease involvement":["Disease variant","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"33.3","intestine":"8.7","lymphoid tissue":"34.8","testis":"33.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"33.0","Early primary spermatocytes":"71.5","Erythrocyte progenitors":"96.5","Late primary spermatocytes":"102.8","Megakaryocyte progenitors":"59.8","Monocyte progenitors":"89.9","Neutrophil progenitors":"42.4","Oocytes":"73.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"96.5","Megakaryocytes":"59.8","Mononuclear phagocytes":"89.9","Oocytes":"73.7","Spermatogenic cell types":"102.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"6.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"3.7","T-cells":"6.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Pancreas - Macrophages","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"5074533.1","Neutrophils":"5758546.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"143492.4","lymphoid tissue":"53171.1"},"Antibody":["HPA002647","HPA003008"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":165,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA002647":null,"HPA003008":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.32e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.98e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.18e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.91e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.60e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"NCBP2L","Gene synonym":[],"Ensembl":"ENSG00000170935","Gene description":"Nuclear cap binding protein subunit 2 like","Uniprot":["A6PVI3"],"Chromosome":"X","Position":"107774899-107795829","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"1.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"5.2","Cardiomyocytes":"9.0","Early spermatids":"22.7","Epicardial cells":"40.9","Late primary spermatocytes":"45.3","Platelets":"17.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"40.9","Platelets":"17.0","Spermatogenic cell types":"45.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"amygdala excitatory":"2.2","upper-layer intratelencephalic":"3.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"78","RNA blood cell specific nTPM":{"basophil":"8.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"78","RNA blood lineage specific nTPM":{"granulocytes":"8.2"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010664":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NCR3LG1","Gene synonym":["B7-H6","DKFZp686O24166"],"Ensembl":"ENSG00000188211","Gene description":"Natural killer cell cytotoxicity receptor 3 ligand 1","Uniprot":["Q68D85"],"Chromosome":"11","Position":"17351800-17377341","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"6.0","parathyroid gland":"7.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"51.4","Epicardial cells":"113.7","monocytes":"41.3","Retinal ganglion cells":"50.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"113.7","Ciliated cells":"51.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"8.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"19000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024137":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NDC80","Gene synonym":["HEC","HEC1","hsNDC80","KNTC2","TID3"],"Ensembl":"ENSG00000080986","Gene description":"NDC80 kinetochore complex component","Uniprot":["O14777"],"Chromosome":"18","Position":"2571557-2616635","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"29.4","lymphoid tissue":"27.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"71.9","Enteric transient amplifying cells":"29.6","Erythrocyte progenitors":"80.5","Extravillous trophoblasts":"31.1","Late primary spermatocytes":"73.0","Megakaryocyte progenitors":"62.0","Monocyte progenitors":"101.4","Neutrophil progenitors":"50.2","Oocytes":"82.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"80.5","Megakaryocytes":"62.0","Mononuclear phagocytes":"101.4","Oocytes":"82.9","Spermatogenic cell types":"73.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"fibroblast":"7.8","leukocyte":"8.8","pericyte":"3.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"7.1","granulocytes":"8.4","T-cells":"11.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Kidney - Fibroblasts","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"5713","Protein cell type specific Intensity":{"Granulosa cells":"813183.9","Neutrophils":"343738.1","Oocytes":"556853.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"822","Protein tissue specific Intensity":{"bone marrow":"82186.9"},"Antibody":["HPA066330"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear speckles","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":114,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"HPA066330":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.06e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.20e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.19e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.45e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"NDE1","Gene synonym":["FLJ20101","NDE","nudE"],"Ensembl":"ENSG00000072864","Gene description":"NudE neurodevelopment protein 1","Uniprot":["Q9NXR1"],"Chromosome":"16","Position":"15643267-15734691","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","Mitosis","Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"27.4","Distal convoluted tubule cells":"23.3","Ependymal cells":"64.3","Late spermatids":"23.6","Microglia":"40.3","Oligodendrocytes":"160.5","Oocytes":"23.0","Papillary tip epithelial cells":"23.7","Podocytes":"27.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"64.3","Glial cells":"160.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"225.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"22.2","monocytes":"11.9","NK-cells":"8.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Liver - Vascular endothelial cells","Skin - Keratinocyte (other)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"725326.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"81016440.4"},"Antibody":["HPA024075"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024075":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.49e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.57e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"}},{"Gene":"NDFIP2","Gene synonym":["KIAA1165","N4wbp5a"],"Ensembl":"ENSG00000102471","Gene description":"Nedd4 family interacting protein 2","Uniprot":["Q9NV92"],"Chromosome":"13","Position":"79481155-79556077","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"404.4","Esophageal apical cells":"719.9","Late spermatids":"495.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"719.9","Spermatogenic cell types":"495.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"28.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"28.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary gland basal cells","Skin - Keratinocyte (other)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2672","Protein tissue specific Intensity":{"cerebral cortex":"267211.7"},"Antibody":["HPA009160"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA009160":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.09e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.83e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"}},{"Gene":"NDNF","Gene synonym":["C4orf31","FLJ23191"],"Ensembl":"ENSG00000173376","Gene description":"Neuron derived neurotrophic factor","Uniprot":["Q8TB73"],"Chromosome":"4","Position":"121035613-121073021","Protein class":["Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":["Neurogenesis"],"Molecular function":null,"Disease involvement":["Disease variant","Hypogonadotropic hypogonadism","Kallmann syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lung":"100.4","placenta":"56.5","retina":"53.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"143.3","Alveolar cells type 2":"65.2","Choroid plexus epithelial cells":"136.0","Cone photoreceptor cells":"68.3","Corticotrophs":"143.2","Early spermatids":"304.6","Late spermatids":"291.7","Podocytes":"470.5","Retinal bipolar cells":"109.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"143.3","Ciliated cells":"136.0","Pituitary endocrine cells":"143.2","Renal nephron cells":"470.5","Spermatogenic cell types":"304.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"34.8","choroid plexus epithelial cell":"70.0","fibroblast":"27.8"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"37.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"15.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Podocytes","Liver - Vascular endothelial cells","Lung - Alveolar cells type 1","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"basal ganglia":"11.1","olfactory bulb":"34.0"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"6611627.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"48636","Protein tissue specific Intensity":{"lung":"4863628.9"},"Antibody":["HPA048881"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":"Secreted in other tissues","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 57: Podocytes - Glomerular filtration","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA048881":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.79e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.39e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"}},{"Gene":"NDRG3","Gene synonym":[],"Ensembl":"ENSG00000101079","Gene description":"NDRG family member 3","Uniprot":["Q9UGV2"],"Chromosome":"20","Position":"36651766-36746090","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"147.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"225.6","Early spermatids":"1128.6","Late primary spermatocytes":"419.0","Late spermatids":"458.0","Rod photoreceptor cells":"194.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1128.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"8649248.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"23168562.5"},"Antibody":["HPA017851","HPA018256"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9700","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA017851":null,"HPA018256":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.56e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.60e-6"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"}},{"Gene":"NDUFA12","Gene synonym":["B17.2","DAP13"],"Ensembl":"ENSG00000184752","Gene description":"NADH:ubiquinone oxidoreductase subunit A12","Uniprot":["Q9UI09"],"Chromosome":"12","Position":"94895297-95003748","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"522.0","tongue":"528.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Parietal cells":"466.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"170933404.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"173234264.8"},"Antibody":["HPA039903"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":55,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039903":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.48e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":63,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA035933":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"}},{"Gene":"NDUFA3","Gene synonym":["B9"],"Ensembl":"ENSG00000170906","Gene description":"NADH:ubiquinone oxidoreductase subunit A3","Uniprot":["O95167"],"Chromosome":"19","Position":"54102728-54109257","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"603.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"618.9","Late spermatids":"3263.1","Parietal cells":"1214.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"1214.5","Spermatogenic cell types":"3263.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":27,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046976":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"}},{"Gene":"NDUFA8","Gene synonym":["MGC793","PGIV"],"Ensembl":"ENSG00000119421","Gene description":"NADH:ubiquinone oxidoreductase subunit A8","Uniprot":["P51970"],"Chromosome":"9","Position":"122144058-122159779","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"356.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"374.1","Late primary spermatocytes":"791.3","Oocytes":"400.6","Parietal cells":"355.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"791.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9300","Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":28,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA041510":null,"HPA041600":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.44e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.26e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":114,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA042268":null,"HPA073212":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":56,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039933":null,"HPA040064":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.39e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.98e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"}},{"Gene":"NDUFAF2","Gene synonym":["B17.2L","mimitin","MMTN","NDUFA12L"],"Ensembl":"ENSG00000164182","Gene description":"NADH:ubiquinone oxidoreductase complex assembly factor 2","Uniprot":["Q8N183"],"Chromosome":"5","Position":"60945177-61154531","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Chaperone"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048082","HPA054776"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":21,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA048082":null,"HPA054776":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.83e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.25e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"NDUFAF3","Gene synonym":["2P1","C3orf60","DKFZP564J0123","E3-3","MGC10527"],"Ensembl":"ENSG00000178057","Gene description":"NADH:ubiquinone oxidoreductase complex assembly factor 3","Uniprot":["Q9BU61"],"Chromosome":"3","Position":"49020459-49023495","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"315.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1025.8","Late primary spermatocytes":"2131.7","Late spermatids":"1761.2","Megakaryocytes":"816.0","Platelets":"516.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"816.0","Spermatogenic cell types":"2131.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"58473747.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"94878791.9","kidney":"26404479.6"},"Antibody":["HPA035376","HPA035377"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":30,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035376":null,"HPA035377":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"}},{"Gene":"NDUFAF5","Gene synonym":["C20orf7","dJ842G6.1"],"Ensembl":"ENSG00000101247","Gene description":"NADH:ubiquinone oxidoreductase complex assembly factor 5","Uniprot":["Q5TEU4"],"Chromosome":"20","Position":"13785007-13821580","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Oxidoreductase","Transferase"],"Disease involvement":["Disease variant","Leigh syndrome","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"19.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"99.0","Myonuclei":"108.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"20597844.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"6066326.0","pancreas":"8296017.3"},"Antibody":["HPA051184"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051184":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"}},{"Gene":"NDUFAF7","Gene synonym":["C2orf56","MidA","PRO1853"],"Ensembl":"ENSG00000003509","Gene description":"NADH:ubiquinone oxidoreductase complex assembly factor 7","Uniprot":["Q7L592"],"Chromosome":"2","Position":"37231631-37253403","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"36.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"176.3","Late primary spermatocytes":"310.1","Late spermatids":"142.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"310.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045217"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045217":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.12e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":56,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA073189":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"}},{"Gene":"NDUFB3","Gene synonym":["B12"],"Ensembl":"ENSG00000119013","Gene description":"NADH:ubiquinone oxidoreductase subunit B3","Uniprot":["O43676"],"Chromosome":"2","Position":"201071433-201085750","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"659.2","tongue":"676.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"767.7","Esophageal suprabasal cells":"596.4","Late primary spermatocytes":"487.3","Parietal cells":"739.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"767.7","Gastric glandular cells":"739.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":83,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034596":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.73e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.00e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.50e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Nuclear membrane","Principal piece"],"Antibody RRID":{"HPA051739":null,"HPA064441":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.70e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.06e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"}},{"Gene":"NDUFB6","Gene synonym":["B17","CI"],"Ensembl":"ENSG00000165264","Gene description":"NADH:ubiquinone oxidoreductase subunit B6","Uniprot":["O95139"],"Chromosome":"9","Position":"32553001-32573184","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1080.7","Late primary spermatocytes":"689.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1080.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":28,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA044001":null,"HPA053334":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.83e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"}},{"Gene":"NDUFB9","Gene synonym":["B22","LYRM3","UQOR22"],"Ensembl":"ENSG00000147684","Gene description":"NADH:ubiquinone oxidoreductase subunit B9","Uniprot":["Q9Y6M9"],"Chromosome":"8","Position":"124539101-124580648","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"1286.6","tongue":"1386.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"813.4","Esophageal suprabasal cells":"779.5","Gastric progenitor cells":"1027.9","Late spermatids":"1280.7","Parietal cells":"1002.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1280.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":55,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA042768":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA044556":null,"HPA062427":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"18000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":42,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038873":null,"HPA056195":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.52e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":89,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA064221":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9700","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":136,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":63,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA018524":null,"HPA067429":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.16e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"}},{"Gene":"NDUFV2","Gene synonym":["CI-24k"],"Ensembl":"ENSG00000178127","Gene description":"NADH:ubiquinone oxidoreductase core subunit V2","Uniprot":["P19404"],"Chromosome":"18","Position":"9102630-9134345","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":["Oxidoreductase","Translocase"],"Disease involvement":["Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"133.9","Enteric stem cells":"115.1","Enteric transient amplifying cells":"147.5","Enterocytes":"173.1","Epididymal basal cells":"113.1","Epididymal clear cells":"122.5","Epididymal efferent duct ciliated cells":"122.1","Epididymal principal cells":"94.1","Gastric chief cells":"88.5","Goblet cells":"87.5","Paneth cells":"108.3","Parietal cells":"244.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"173.1","Gastric glandular cells":"244.0","Proliferating cells":"147.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":110,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA003404":null,"HPA077896":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"}},{"Gene":"NDUFV3","Gene synonym":["CI-10k"],"Ensembl":"ENSG00000160194","Gene description":"NADH:ubiquinone oxidoreductase subunit V3","Uniprot":["P56181"],"Chromosome":"21","Position":"42879644-42913304","Protein class":["FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"30.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"2576.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2576.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"40236629.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"358706607.0"},"Antibody":["HPA019791","HPA020463","HPA030427","CAB034142"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":28,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB034142":null,"HPA019791":null,"HPA020463":null,"HPA030427":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.73e-4"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"}},{"Gene":"NEBL","Gene synonym":["bA165O3.1","C10orf113","LASP2","LNEBL"],"Ensembl":"ENSG00000078114","Gene description":"Nebulette","Uniprot":["O76041"],"Chromosome":"10","Position":"20779973-21293011","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"heart muscle":"292.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1700.5","Cardiomyocytes":"3558.9","Ependymal cells":"1682.0","Podocytes":"4258.9","Retinal horizontal cells":"1474.5","Salivary acinar cells":"1532.5","Salivary ionocytes":"1416.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"3558.9","Renal nephron cells":"4258.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"10.1"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":33,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013994":null,"HPA013995":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.15e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.28e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NECAB3","Gene synonym":["APBA2BP","dJ63M2.4","dJ63M2.5","EFCBP3","NIP1","SYTIP2","XB51"],"Ensembl":"ENSG00000125967","Gene description":"N-terminal EF-hand calcium binding protein 3","Uniprot":["Q96P71"],"Chromosome":"20","Position":"33657087-33674463","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"101.0","Late primary spermatocytes":"72.9","Late spermatids":"74.3","Oocytes":"59.9","Parietal cells":"70.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"101.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"310351.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"46119","Protein tissue specific Intensity":{"cerebral cortex":"2521993.1","skeletal muscle":"6701880.0"},"Antibody":["HPA044785","HPA070595","HPA071786"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus"],"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA044785":null,"HPA070595":null,"HPA071786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"}},{"Gene":"NECTIN3","Gene synonym":["CD113","CDw113","DKFZP566B0846","nectin-3","PPR3","PVRL3","PVRR3"],"Ensembl":"ENSG00000177707","Gene description":"Nectin cell adhesion molecule 3","Uniprot":["Q9NQS3"],"Chromosome":"3","Position":"111070071-111275563","Protein class":["CD markers","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"51.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"315.4","Late spermatids":"392.1","Mucous neck cells":"266.9","Oligodendrocyte progenitor cells":"241.4","Sertoli cells":"317.0","Syncytiotrophoblasts":"348.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"317.0","Spermatogenic cell types":"392.1","Trophoblast cells":"348.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"355.0","upper-layer intratelencephalic":"345.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Spleen - Fibroblasts_1","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"15335.9","Microglia and Neuropil":"26518.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1947823.0","Stomach":"1822197.8"},"Antibody":["CAB009869","HPA011038"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cell Junctions","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3500000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":24,"Subcellular main location":["Cell Junctions","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB009869":null,"HPA011038":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"}},{"Gene":"NEDD1","Gene synonym":["GCP-WD","TUBGCP7"],"Ensembl":"ENSG00000139350","Gene description":"NEDD1 gamma-tubulin ring complex targeting factor","Uniprot":["Q8NHV4"],"Chromosome":"12","Position":"96907224-96953780","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"235.9","Late primary spermatocytes":"254.1","Late spermatids":"131.4","Neutrophil progenitors":"116.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"254.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"75.2","ependymal cell":"85.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"4467138.7"},"Antibody":["HPA038591"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":69,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA038591":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.11e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.86e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"}},{"Gene":"NEFM","Gene synonym":["NEF3","NF-M","NFM"],"Ensembl":"ENSG00000104722","Gene description":"Neurofilament medium chain","Uniprot":["P07197"],"Chromosome":"8","Position":"24913758-24919098","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"brain":"308.0","retina":"84.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"49.8","Breast myoepithelial cells":"42.2","Corticotrophs":"114.9","Early spermatids":"81.4","Gonadotrophs":"151.8","Late primary spermatocytes":"121.9","Late spermatids":"178.3","Oocytes":"50.7","Other brain neurons":"54.5","Pancreatic islet cells":"58.5","Retinal ganglion cells":"135.2","Thymic myoid cells":"58.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"135.2","Pituitary endocrine cells":"151.8","Spermatogenic cell types":"178.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"249.4","thalamic excitatory":"202.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"16.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"56.7","Neuroblastoma":"79.7","Rhabdoid":"129.8"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"800000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":43,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"CAB010900":null,"CAB012976":null,"HPA022845":null,"HPA023138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA038941":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"}},{"Gene":"NEK11","Gene synonym":["FLJ23495"],"Ensembl":"ENSG00000114670","Gene description":"NIMA related kinase 11","Uniprot":["Q8NG66"],"Chromosome":"3","Position":"131026850-131350465","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"41.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"375.7","Choroid plexus epithelial cells":"796.6","Early spermatids":"302.0","Endometrial ciliated cells":"361.0","Ependymal cells":"1378.7","Epididymal efferent duct ciliated cells":"332.4","Fallopian tube ciliated cells":"408.7","Late spermatids":"307.0","Respiratory ciliated cells":"779.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1378.7","Myocytes":"375.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"699.1","ependymal cell":"1507.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA016908":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"}},{"Gene":"NEK2","Gene synonym":["NEK2A","NLK1","PPP1R111","RP67"],"Ensembl":"ENSG00000117650","Gene description":"NIMA related kinase 2","Uniprot":["P51955"],"Chromosome":"1","Position":"211658657-211675630","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Chromosome partition","Meiosis","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"16.7","lymphoid tissue":"17.9","testis":"62.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"413.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"413.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"2.5","hippocampal CA4":"2.6","upper-layer intratelencephalic":"1.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebellum":"5.7"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017530","HPA064967"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytokinetic bridge","Primary cilium","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":48,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Cytokinetic bridge","Primary cilium","Basal body"],"Antibody RRID":{"CAB017530":null,"HPA064967":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.77e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.90e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.70e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.66e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.35e-4"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"}},{"Gene":"NEK3","Gene synonym":["HSPK36","MGC29949"],"Ensembl":"ENSG00000136098","Gene description":"NIMA related kinase 3","Uniprot":["P51956"],"Chromosome":"13","Position":"52132639-52159861","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oligodendrocytes":"121.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"121.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"123.8","oligodendrocyte":"159.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"226930.1","Fallopian tube cells":"231386.2","Granulosa cells":"192344.9","Large ducts":"197950.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"14062","Protein tissue specific Intensity":{"intestine":"568798.3","Stomach":"2243602.5"},"Antibody":["HPA019062","HPA043230"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Microtubules","Cytokinetic bridge","Mitotic spindle","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 104: Brain endothelial cells - Blood brain barrier","Interactions":1,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Plasma membrane","Cytokinetic bridge","Mitotic spindle","Primary cilium"],"Antibody RRID":{"HPA019062":null,"HPA043230":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-3"}},{"Gene":"NEK4","Gene synonym":["NRK2","pp12301","STK2"],"Ensembl":"ENSG00000114904","Gene description":"NIMA related kinase 4","Uniprot":["P51957"],"Chromosome":"3","Position":"52708444-52770946","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"43.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"102.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"1727010.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1273455.2"},"Antibody":["HPA015750","HPA058543"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":30,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA015750":null,"HPA058543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.18e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"}},{"Gene":"NEK5","Gene synonym":[],"Ensembl":"ENSG00000197168","Gene description":"NIMA related kinase 5","Uniprot":["Q6P3R8"],"Chromosome":"13","Position":"52033611-52129092","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"8.1","testis":"10.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"152.4","Endometrial ciliated cells":"188.0","Ependymal cells":"663.9","Epididymal efferent duct ciliated cells":"164.5","Fallopian tube ciliated cells":"270.0","Respiratory ciliated cells":"469.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"663.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"738.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"6.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"1855424.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3933","Protein tissue specific Intensity":{"bone marrow":"263832.6","lymphoid tissue":"522794.7"},"Antibody":["HPA035565","HPA037016","HPA041399"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035565":null,"HPA037016":null,"HPA041399":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"}},{"Gene":"NELFE","Gene synonym":["D6S45","NELF-E","RD","RDBP","RDP"],"Ensembl":"ENSG00000204356","Gene description":"Negative elongation factor complex member E","Uniprot":["P18615"],"Chromosome":"6","Position":"31952087-31959038","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"2521.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2521.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"8150273.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"15029830.1"},"Antibody":["HPA007187","HPA007594","HPA046502"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":32,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA007187":null,"HPA007594":null,"HPA046502":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.09e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"}},{"Gene":"NELL1","Gene synonym":["FLJ45906","IDH3GL"],"Ensembl":"ENSG00000165973","Gene description":"Neural EGFL like 1","Uniprot":["Q92832"],"Chromosome":"11","Position":"20669551-21575686","Protein class":["Predicted secreted proteins"],"Biological process":["Differentiation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"12.8","kidney":"15.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"276.9","Brain inhibitory neurons":"361.2","Distal convoluted tubule cells":"369.3","Gonadotrophs":"378.6","Late primary spermatocytes":"161.8","Loop of henle epithelial cells":"241.5","Medullary thymic epithelial cells":"314.4","Mesothelial cells":"145.6","Oligodendrocyte progenitor cells":"388.7","Other brain neurons":"116.1","Podocytes":"257.6","Renal collecting duct intercalated cells":"123.2","Renal connecting tubule cells":"109.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"388.7","Neuronal cells":"361.2","Pituitary endocrine cells":"378.6","Renal nephron cells":"369.3","Secretory gland support":"314.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"1859.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"17.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"7.7","Neuroblastoma":"9.8","Rhabdoid":"8.7","skin cancer":"8.1"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Colon enteroendocrine cells","Minor Salivary Gland - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"162914.2","Oocytes":"648603.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1223","Protein tissue specific Intensity":{"lymphoid tissue":"122274.5"},"Antibody":["HPA051535"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051535":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.16e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"}},{"Gene":"NEMP2","Gene synonym":["TMEM194B"],"Ensembl":"ENSG00000189362","Gene description":"Nuclear envelope integral membrane protein 2","Uniprot":["A6NFY4"],"Chromosome":"2","Position":"190504338-190534722","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"40.9","Thymocytes":"28.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"40.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"807","Protein tissue specific Intensity":{"lymphoid tissue":"80653.9"},"Antibody":["HPA057719"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA057719":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.55e-5"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.31e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"}},{"Gene":"NEURL1","Gene synonym":["h-neu","neu-1","NEURL","RNF67"],"Ensembl":"ENSG00000107954","Gene description":"Neuralized E3 ubiquitin protein ligase 1","Uniprot":["O76050"],"Chromosome":"10","Position":"103493705-103592546","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Notch signaling pathway","Translation regulation","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"63.3","skeletal muscle":"136.2","tongue":"55.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"296.0","Early spermatids":"209.5","Goblet cells":"197.5","Late spermatids":"788.9","Retinal bipolar cells":"190.9","Rod photoreceptor cells":"379.7","Salivary ionocytes":"212.1","Syncytiotrophoblasts":"240.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"379.7","Spermatogenic cell types":"788.9","Trophoblast cells":"240.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"intermediate monocyte":"44.8","non-classical monocyte":"111.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"19","RNA blood lineage specific nTPM":{"monocytes":"111.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enterocytes","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"284619.2","Neurons":"618816.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"340","Protein tissue specific Intensity":{"cerebral cortex":"33970.5"},"Antibody":["HPA044204"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044204":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"}},{"Gene":"NEUROD1","Gene synonym":["BETA2","BHF-1","bHLHa3","MODY6","NEUROD"],"Ensembl":"ENSG00000162992","Gene description":"Neuronal differentiation 1","Uniprot":["Q13562"],"Chromosome":"2","Position":"181668295-181680827","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding"],"Disease involvement":["Diabetes mellitus","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"brain":"166.9","retina":"131.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Neuroendocrine cells":"66.8","Rod photoreceptor cells":"24.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Enteroendocrine cells":"66.8","Neuronal cells":"24.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"upper rhombic lip":"14.2"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.2","Lung Adenocarcinoma (TCGA)":"2.4","Pancreatic Adenocarcinoma (TCGA)":"8.3","Stomach Adenocarcinoma (TCGA)":"2.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"cerebellum":"149.5"},"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"18.9","Neuroblastoma":"16.4"},"RNA tissue cell type enrichment":["Pancreas - Alpha cells","Pancreas - Beta cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"14","RNA mouse brain regional specific nTPM":{"cerebellum":"216.2"},"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":"20","RNA pig brain regional specific nTPM":{"cerebellum":"290.8"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1525","Protein cell type specific Intensity":{"Glomeruli":"152529.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003278","CAB022450"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB022450":null,"HPA003278":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.32e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.36e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"HPA015545":null,"HPA026998":null,"HPA055750":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NEUROG2","Gene synonym":["Atoh4","bHLHa8","Math4A","ngn-2","NGN2"],"Ensembl":"ENSG00000178403","Gene description":"Neurogenin 2","Uniprot":["Q9H2A3"],"Chromosome":"4","Position":"112513516-112516180","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.1","testis":"1.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"6.0","Early spermatids":"2.0","Late primary spermatocytes":"2.9","Late spermatids":"1.6","M\u00fcller glia":"8.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Glial cells":"8.4","Secretory gland support":"6.0","Spermatogenic cell types":"2.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"14.1","hippocampal CA4":"4.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Neuroblastoma":"15.0"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB012342":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":64,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"CAB005385":null,"HPA003097":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"}},{"Gene":"NFATC3","Gene synonym":["NFAT4","NFATX"],"Ensembl":"ENSG00000072736","Gene description":"Nuclear factor of activated T cells 3","Uniprot":["Q12968"],"Chromosome":"16","Position":"68084751-68229259","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"95.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"359.8","Podocytes":"353.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"314.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":3,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA050665":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"}},{"Gene":"NFS1","Gene synonym":["IscS","NifS"],"Ensembl":"ENSG00000244005","Gene description":"NFS1 cysteine desulfurase","Uniprot":["Q9Y697"],"Chromosome":"20","Position":"35668052-35699355","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Molybdenum cofactor biosynthesis"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"20.4","Cardiomyocytes":"19.0","Myonuclei":"24.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"24.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"54429445.4","heart muscle":"49650870.5","kidney":"16527249.2"},"Antibody":["CAB034314","HPA051801","HPA054755"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":11,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB034314":null,"HPA051801":null,"HPA054755":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.16e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"}},{"Gene":"NFU1","Gene synonym":["CGI-33","HIRIP5","NifU","NIFUC"],"Ensembl":"ENSG00000169599","Gene description":"NFU1 iron-sulfur cluster scaffold","Uniprot":["Q9UMS0"],"Chromosome":"2","Position":"69396113-69437628","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"189.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"22249128.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"97596155.9"},"Antibody":["HPA035826"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":19,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035826":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"}},{"Gene":"NFXL1","Gene synonym":["HOZFP"],"Ensembl":"ENSG00000170448","Gene description":"Nuclear transcription factor, X-box binding like 1","Uniprot":["Q6ZNB6"],"Chromosome":"4","Position":"47847233-47914667","Protein class":["Predicted membrane proteins","Transcription factors"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Cardiomyocytes":"987.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Myocytes":"987.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"655104.5","Pancreas epithelial cells":"1147149.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"12608.0","salivary gland":"13441.4","Stomach":"32562.5"},"Antibody":["HPA059132"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA059132":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.42e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"NFYA","Gene synonym":["CBF-B","HAP2","NF-YA"],"Ensembl":"ENSG00000001167","Gene description":"Nuclear transcription factor Y subunit alpha","Uniprot":["P23511"],"Chromosome":"6","Position":"41072974-41102403","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"86.8","Neutrophils":"180.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"180.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"302942.4","kidney":"1080306.5","lymphoid tissue":"645366.6","ovary":"1051907.0"},"Antibody":["CAB009250","HPA050779"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB009250":null,"HPA050779":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.35e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"NGLY1","Gene synonym":["FLJ11005","PNG-1","PNG1"],"Ensembl":"ENSG00000151092","Gene description":"N-glycanase 1","Uniprot":["Q96IV0"],"Chromosome":"3","Position":"25718944-25790039","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"729.2","Late spermatids":"1594.6","Pancreatic acinar cells":"463.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1594.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"10153642.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036825"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 6: Plasmacytoid dendritic cells - Viral sensing & interferon response","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036825":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.81e-5"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.91e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"}},{"Gene":"NHEJ1","Gene synonym":["Cernunnos","FLJ12610","XLF"],"Ensembl":"ENSG00000187736","Gene description":"Non-homologous end joining factor 1","Uniprot":["Q9H9Q4"],"Chromosome":"2","Position":"219069355-219160869","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","SCID"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"29.0","Enteric transient amplifying cells":"11.1","Enterocytes":"14.7","Goblet cells":"22.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"29.0","Goblet cells":"22.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"5121756.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"544642.9","lymphoid tissue":"834352.2"},"Antibody":["CAB012334","HPA043869"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000","Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"CAB012334":null,"HPA043869":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.43e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.29e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.42e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.92e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"NICN1","Gene synonym":["MGC12936"],"Ensembl":"ENSG00000145029","Gene description":"Nicolin 1, tubulin polyglutamylase complex subunit","Uniprot":["Q9BSH3"],"Chromosome":"3","Position":"49422333-49429326","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Astrocytes":"2.4","Bergmann glia":"3.1","Brain excitatory neurons":"2.8","Brain inhibitory neurons":"2.9","Choroid plexus epithelial cells":"1.8","Ependymal cells":"1.9","Microglia":"2.8","Oligodendrocyte progenitor cells":"2.5","Oligodendrocytes":"1.9","Other brain neurons":"2.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"1.9","Glial cells":"3.1","Neuronal cells":"2.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"20.4"},"RNA tissue cell type enrichment":["Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"291111.7","Microglia and Neuropil":"125731.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA058014"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA058014":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.51e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.55e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-1"}},{"Gene":"NIP7","Gene synonym":["CGI-37","FLJ10296","HSPC031","KD93"],"Ensembl":"ENSG00000132603","Gene description":"Nucleolar pre-rRNA processing protein NIP7","Uniprot":["Q9Y221"],"Chromosome":"16","Position":"69337996-69343106","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"77.7","Gastric progenitor cells":"71.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"7180351.0","T-cells":"7827464.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3229","Protein tissue specific Intensity":{"fallopian tube":"244190.4","intestine":"579123.5","lymphoid tissue":"145287.3"},"Antibody":["HPA040856","HPA059850"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":17,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA040856":null,"HPA059850":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.02e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA071697":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 57: Podocytes - Glomerular filtration","Interactions":11,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA041352":null,"HPA049413":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.81e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.75e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.16e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"}},{"Gene":"NKIRAS1","Gene synonym":["kappaB-Ras1","KBRAS1"],"Ensembl":"ENSG00000197885","Gene description":"NFKB inhibitor interacting Ras like 1","Uniprot":["Q9NYS0"],"Chromosome":"3","Position":"23889951-23946591","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"115.9","Epicardial cells":"204.7","Oocytes":"156.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"204.7","Oocytes":"156.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA077387":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.94e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.15e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.39e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"}},{"Gene":"NKX1-1","Gene synonym":["HSPX153","SAX2"],"Ensembl":"ENSG00000235608","Gene description":"NK1 homeobox 1","Uniprot":["Q15270"],"Chromosome":"4","Position":"1402932-1406442","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"medulla oblongata":"1.6"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA029367":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 4: Breast lactating luminal cells - Lactation","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA027564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB070169":null,"HPA036774":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.85e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"}},{"Gene":"NLGN1","Gene synonym":["KIAA1070"],"Ensembl":"ENSG00000169760","Gene description":"Neuroligin 1","Uniprot":["Q8N2Q7"],"Chromosome":"3","Position":"173396284-174294372","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Biological rhythms","Cell adhesion"],"Molecular function":null,"Disease involvement":["Autism","Autism spectrum disorder","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"11.9","retina":"10.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"2031.3","Brain excitatory neurons":"2520.1","Brain inhibitory neurons":"2278.4","Choroid plexus epithelial cells":"2267.6","Lactotrophs":"2989.7","Oligodendrocyte progenitor cells":"5377.0","Oligodendrocytes":"2349.8","Other brain neurons":"1592.0","Proximal tubule cells":"1250.4","Thyrotrophs":"1127.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2267.6","Glial cells":"5377.0","Neuronal cells":"2520.1","Pituitary endocrine cells":"2989.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.7","Kidney Renal Clear Cell Carcinoma (TCGA)":"9.8","Kidney Renal Papillary Cell Carcinoma (TCGA)":"7.1","Skin Cutaneous Melanoma (TCGA)":"8.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"12.1"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"79000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"CAB033261":null,"HPA006572":null,"HPA006680":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NLK","Gene synonym":[],"Ensembl":"ENSG00000087095","Gene description":"Nemo like kinase","Uniprot":["Q9UBE8"],"Chromosome":"17","Position":"28041737-28196381","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"72.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"888.5","Cone photoreceptor cells":"931.6","Podocytes":"841.9","Retinal bipolar cells":"612.9","Retinal pigment epithelial cells":"989.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"888.5","Neuronal cells":"931.6","Pigment cells":"989.0","Renal nephron cells":"841.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"45","RNA blood cell specific nTPM":{"basophil":"30.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"45","RNA blood lineage specific nTPM":{"granulocytes":"30.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 18: Adrenal cortex cells - Steroidogensis","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cell Junctions"],"Antibody RRID":{"HPA018192":null,"HPA056511":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"}},{"Gene":"NLRC3","Gene synonym":["CLR16.2","FLJ00348","NOD3"],"Ensembl":"ENSG00000167984","Gene description":"NLR family CARD domain containing 3","Uniprot":["Q7RTR2"],"Chromosome":"16","Position":"3539033-3577403","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"6.1","lymphoid tissue":"12.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"35.0","Cardiomyocytes":"96.9","Endometrial ciliated cells":"24.9","Epicardial cells":"61.4","Hematopoietic stem cells":"27.2","Innate lymphoid cells":"58.9","Megakaryocyte-Erythroid progenitors":"26.7","NK-cells":"107.6","Respiratory ciliated cells":"24.5","T-cells":"73.6","Thymocytes":"41.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"61.4","Innate lymphoid cells":"58.9","Myocytes":"96.9","NK-cells":"107.6","T-cells":"73.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"leukocyte":"91.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Leukemia":"10.5","lymphoma":"10.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Adrenal gland - T-cells","Breast - T-cells","Kidney - T-cells","Liver - T-cells","Lung - T-cells","Minor Salivary Gland - T-cells","Prostate - T-cells","Spleen - B-cells (Spleen)","Stomach - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"3387740.7","T-cells":"3075459.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5753","Protein tissue specific Intensity":{"lymphoid tissue":"575334.0"},"Antibody":["HPA048062"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles","Centriolar satellite"],"Antibody RRID":{"HPA048062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.36e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.21e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"NLRP14","Gene synonym":["CLR11.2","GC-LRR","Nalp-iota","NALP14","NOD5","PAN8"],"Ensembl":"ENSG00000158077","Gene description":"NLR family pyrin domain containing 14","Uniprot":["Q86W24"],"Chromosome":"11","Position":"7020479-7071526","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"5.6","Ependymal cells":"6.8","Late primary spermatocytes":"4.0","Loop of henle epithelial cells":"4.0","Oocytes":"9.2","Paneth cells":"3.9","Plasma cells":"5.8","Podocytes":"4.6","Proximal tubule cells":"7.0","Renal collecting duct intercalated cells":"5.8","Renal connecting tubule cells":"3.9","Retinal bipolar cells":"4.7","Rod photoreceptor cells":"5.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"6.8","Ductal cells":"5.8","Neuronal cells":"5.2","Oocytes":"9.2","Plasma cells":"5.8","Renal nephron cells":"7.0","Spermatogenic cell types":"5.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"8.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Plasma cells","Spleen - Plasma cells","Stomach - Plasma cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7159","Protein cell type specific Intensity":{"Oocytes":"715907.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039477"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":86,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA028010":null,"HPA028334":null,"HPA038014":null,"HPA054289":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.92e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"NME8","Gene synonym":["CILD6","DNAI8","NM23-H8","SPTRX2","TXNDC3"],"Ensembl":"ENSG00000086288","Gene description":"NME\/NM23 family member 8","Uniprot":["Q8N427"],"Chromosome":"7","Position":"37848597-37900397","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","Hydrolase"],"Disease involvement":["Ciliopathy","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"bone marrow":"11.6","testis":"9.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"33.9","Late primary spermatocytes":"74.6","Late spermatids":"27.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"74.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"1.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"4.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"1.2"},"RNA tissue cell type enrichment":["Kidney - T-cells","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"10315","Protein tissue specific Intensity":{"heart muscle":"1031462.3"},"Antibody":["CAB016416","HPA019259","HPA029572"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear speckles","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Nuclear speckles","Primary cilium"],"Antibody RRID":{"CAB016416":null,"HPA019259":null,"HPA029572":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NME9","Gene synonym":["NM23-H9","TXL-2","TXNDC6"],"Ensembl":"ENSG00000181322","Gene description":"NME\/NM23 family member 9","Uniprot":["Q86XW9"],"Chromosome":"3","Position":"138261437-138329886","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"19.5","fallopian tube":"16.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"97.4","Cardiomyocytes":"165.4","Choroid plexus epithelial cells":"170.9","Ependymal cells":"263.8","Epicardial cells":"109.2","Fallopian tube ciliated cells":"95.8","Myonuclei":"102.3","Oligodendrocyte progenitor cells":"159.3","Respiratory ciliated cells":"159.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"109.2","Ciliated cells":"263.8","Glial cells":"159.3","Myocytes":"165.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"279.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"92337","Protein cell type specific Intensity":{"Fallopian tube cells":"9233667.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"132294","Protein tissue specific Intensity":{"fallopian tube":"13229403.7"},"Antibody":["CAB020943","HPA040000","HPA043881"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"CAB020943":null,"HPA040000":null,"HPA043881":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"}},{"Gene":"NMNAT3","Gene synonym":["PNAT3"],"Ensembl":"ENSG00000163864","Gene description":"Nicotinamide nucleotide adenylyltransferase 3","Uniprot":["Q96T66"],"Chromosome":"3","Position":"139560180-139678017","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Pyridine nucleotide biosynthesis"],"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"179.9","Late primary spermatocytes":"172.0","Late spermatids":"333.2","Megakaryocyte progenitors":"169.7","Myonuclei":"152.7","Rod photoreceptor cells":"178.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"333.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skeletal muscle - Skeletal myocytes","Skin - Keratinocyte (other)","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"55910871.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"30174300.9"},"Antibody":["HPA039077","HPA057402"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA039077":null,"HPA057402":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.17e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"}},{"Gene":"NOL10","Gene synonym":["FLJ14075","PQBP5"],"Ensembl":"ENSG00000115761","Gene description":"Nucleolar protein 10","Uniprot":["Q9BSC4"],"Chromosome":"2","Position":"10562347-10689987","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"17123916.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"363545.7"},"Antibody":["HPA035286","HPA043075"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":10,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA035286":null,"HPA043075":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.63e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.53e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.93e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.63e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"NOL12","Gene synonym":["MGC3731","Nop25","RRP17"],"Ensembl":"ENSG00000273899","Gene description":"Nucleolar protein 12","Uniprot":["Q9UGY1"],"Chromosome":"22","Position":"37681673-37693476","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding","rRNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"14.9","Brain inhibitory neurons":"13.6","Colonocytes":"17.3","Early spermatids":"50.2","Enteric transient amplifying cells":"14.5","Enterocytes":"15.6","Goblet cells":"13.9","Late primary spermatocytes":"35.7","Late spermatids":"14.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"50.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"747047.7","T-cells":"780749.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"290050.6"},"Antibody":["HPA003547"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Mitotic chromosome","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":42,"Subcellular main location":["Nucleoli","Mitotic chromosome"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA003547":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"}},{"Gene":"NOL4","Gene synonym":["CT125","HRIHFB2255","NOLP"],"Ensembl":"ENSG00000101746","Gene description":"Nucleolar protein 4","Uniprot":["O94818"],"Chromosome":"18","Position":"33851100-34224952","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.6","pituitary gland":"6.3","retina":"5.8","testis":"11.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"191.5","Bergmann glia":"210.9","Brain excitatory neurons":"225.4","Brain inhibitory neurons":"256.0","Corticotrophs":"1001.4","Early spermatids":"389.7","Gonadotrophs":"252.9","Lactotrophs":"567.9","Late primary spermatocytes":"279.7","Oligodendrocyte progenitor cells":"454.9","Other brain neurons":"250.5","Pancreatic islet cells":"397.4","Somatotrophs":"523.0","Thyrotrophs":"493.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"454.9","Neuronal cells":"256.0","Pancreatic islet cells":"397.4","Pituitary endocrine cells":"1001.4","Spermatogenic cell types":"389.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.2","Kidney Renal Papillary Cell Carcinoma (TCGA)":"2.4","Pancreatic Adenocarcinoma (TCGA)":"1.9","Prostate Adenocarcinoma (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"8.6","Neuroblastoma":"7.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA046740":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NOL4L","Gene synonym":["C20orf112","C20orf113","dJ1184F4.2","dJ1184F4.4","DKFZP566G1424"],"Ensembl":"ENSG00000197183","Gene description":"Nucleolar protein 4 like","Uniprot":["Q96MY1"],"Chromosome":"20","Position":"32443059-32585333","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"45.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"217.2","Late primary spermatocytes":"181.7","Late spermatids":"203.3","Megakaryocyte progenitors":"141.9","Megakaryocyte-Erythroid progenitors":"155.9","Oocytes":"156.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"217.2","Spermatogenic cell types":"203.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA041768":null,"HPA043600":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":20,"Subcellular main location":["Nucleoli","Mitotic chromosome"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA029185":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.78e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.90e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.60e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"}},{"Gene":"NOS1AP","Gene synonym":["CAPON","KIAA0464"],"Ensembl":"ENSG00000198929","Gene description":"Nitric oxide synthase 1 adaptor protein","Uniprot":["O75052"],"Chromosome":"1","Position":"162069691-162370475","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"16.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"778.7","Choroid plexus epithelial cells":"299.7","Distal convoluted tubule cells":"749.4","Podocytes":"515.7","Renal collecting duct principal cells":"339.9","Renal connecting tubule cells":"293.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"778.7","Renal nephron cells":"749.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"2250481.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"13060706.6","liver":"15839184.5"},"Antibody":["CAB018582","HPA030066","HPA055561"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":24,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB018582":null,"HPA030066":null,"HPA055561":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NOSIP","Gene synonym":["CGI-25"],"Ensembl":"ENSG00000142546","Gene description":"Nitric oxide synthase interacting protein","Uniprot":["Q9Y314"],"Chromosome":"19","Position":"49555468-49590262","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Developmental protein","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"345.5","Esophageal apical cells":"288.6","Late primary spermatocytes":"604.9","Late spermatids":"1225.5","Pancreatic acinar cells":"295.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1225.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"4386294.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2236516.3"},"Antibody":["HPA043464","HPA062132"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043464":null,"HPA062132":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"}},{"Gene":"NOTCH2NLA","Gene synonym":["N2N","NOTCH2NL"],"Ensembl":"ENSG00000264343","Gene description":"Notch 2 N-terminal like A","Uniprot":["Q7Z3S9"],"Chromosome":"1","Position":"146146203-146229041","Protein class":["Disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Differentiation","Notch signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Tuft cells":"23.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Secretory gland support":"23.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"40.4","classical monocyte":"46.9","eosinophil":"90.4","intermediate monocyte":"40.9","memory B-cell":"76.3","myeloid DC":"61.1","naive B-cell":"44.2","neutrophil":"42.9","non-classical monocyte":"42.1","plasmacytoid DC":"49.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":203,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB004669":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"}},{"Gene":"NOX5","Gene synonym":["NOX5A","NOX5B"],"Ensembl":"ENSG00000255346","Gene description":"NADPH oxidase 5","Uniprot":["Q96PH1"],"Chromosome":"15","Position":"69014695-69062762","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Angiogenesis","Electron transport","Ion transport","Transport"],"Molecular function":["Ion channel","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"lymphoid tissue":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"1.8","Brain inhibitory neurons":"2.9","Choroid plexus epithelial cells":"1.7","Distal convoluted tubule cells":"2.8","Ependymal cells":"2.5","Loop of henle epithelial cells":"4.0","Other brain neurons":"1.7","Papillary tip epithelial cells":"2.9","Podocytes":"4.4","Proximal tubule cells":"4.3","Renal collecting duct intercalated cells":"7.7","Renal collecting duct principal cells":"5.6","Renal connecting tubule cells":"3.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2.5","Ductal cells":"7.7","Neuronal cells":"2.9","Renal nephron cells":"4.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"pancreatic cancer":"1.0","skin cancer":"1.0"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NOXRED1","Gene synonym":["C14orf148","FLJ32809"],"Ensembl":"ENSG00000165555","Gene description":"NADP dependent oxidoreductase domain containing 1","Uniprot":["Q6NXP6"],"Chromosome":"14","Position":"77394021-77423523","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"retina":"4.0","testis":"5.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"152.5","Late primary spermatocytes":"76.9","Late spermatids":"182.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"182.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA055658":null,"HPA060408":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NPHP1","Gene synonym":["JBTS4","NPH1","SLSN1"],"Ensembl":"ENSG00000144061","Gene description":"Nephrocystin 1","Uniprot":["O15259"],"Chromosome":"2","Position":"110122311-110205066","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome","Leber congenital amaurosis","Nephronophthisis","Senior-Loken syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"36.0","skeletal muscle":"34.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"215.2","Endometrial ciliated cells":"239.5","Ependymal cells":"312.7","Epididymal efferent duct ciliated cells":"144.0","Fallopian tube ciliated cells":"230.3","Late primary spermatocytes":"289.2","Myonuclei":"568.1","Respiratory ciliated cells":"338.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"338.5","Myocytes":"568.1","Spermatogenic cell types":"289.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"340.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046093":null,"HPA074071":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"}},{"Gene":"NPIPB6","Gene synonym":[],"Ensembl":"ENSG00000198156","Gene description":"Nuclear pore complex interacting protein family member B6","Uniprot":["E9PJ23"],"Chromosome":"16","Position":"28342517-28363508","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"36.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"53","RNA single cell type specific nCPM":{"Early spermatids":"287.1","Late primary spermatocytes":"129.5","Late spermatids":"198.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"74","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"287.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"4.7"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA011188":null,"HPA053611":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"}},{"Gene":"NPIPB8","Gene synonym":[],"Ensembl":"ENSG00000255524","Gene description":"Nuclear pore complex interacting protein family member B8","Uniprot":["E9PQR5"],"Chromosome":"16","Position":"28637654-28658744","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"16.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"28.1","Late spermatids":"10.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"28.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"1.4"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA011188":null,"HPA053611":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NPL","Gene synonym":["C1orf13","DHDPS1","NPL1"],"Ensembl":"ENSG00000135838","Gene description":"N-acetylneuraminate pyruvate lyase","Uniprot":["Q9BXD5"],"Chromosome":"1","Position":"182789293-182830384","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism"],"Molecular function":["Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"42.4","placenta":"37.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"380.2","Cytotrophoblasts":"232.1","Hofbauer cells":"1197.9","Kupffer cells":"465.3","Macrophages":"234.2","Microglia":"336.1","monocytes":"213.9","Neutrophils":"599.3","Proximal tubule cells":"197.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"380.2","Mononuclear phagocytes":"1197.9","Neutrophils":"599.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"523.2","central nervous system macrophage":"434.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"440.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"35","RNA blood lineage specific nTPM":{"granulocytes":"440.3","monocytes":"134.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Adrenal gland - Macrophages","Breast - Macrophages","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Lung - Macrophages","Pituitary gland - Macrophages","Spleen - Macrophages","Stomach - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"49826689.7","Macrophages":"21946041.5","Proximal tubules":"36354464.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"6202745.0","lymphoid tissue":"4403002.6"},"Antibody":["HPA028345","HPA075808"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"150000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA028345":null,"HPA075808":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"NPRL2","Gene synonym":["NPR2","NPR2L","TUSC4"],"Ensembl":"ENSG00000114388","Gene description":"NPR2 like, GATOR1 complex subunit","Uniprot":["Q8WTW4"],"Chromosome":"3","Position":"50347330-50350826","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":["Disease variant","Epilepsy","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"90.7","Late primary spermatocytes":"66.0","Late spermatids":"93.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"93.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"496969.6","Fallopian tube cells":"473318.8","Oocytes":"522119.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038196","HPA038197"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":40,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038196":null,"HPA038197":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.26e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.18e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"}},{"Gene":"NPTX1","Gene synonym":[],"Ensembl":"ENSG00000171246","Gene description":"Neuronal pentraxin 1","Uniprot":["Q15818"],"Chromosome":"17","Position":"80466834-80477843","Protein class":["Predicted intracellular proteins","Predicted secreted proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"188.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Brain excitatory neurons":"102.3","Cone photoreceptor cells":"107.6","Late spermatids":"103.4","Retinal amacrine cells":"31.7","Somatotrophs":"33.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"107.6","Pituitary endocrine cells":"33.7","Spermatogenic cell types":"103.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"234.2","deep-layer intratelencephalic":"202.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"10.2","Lung Adenocarcinoma (TCGA)":"9.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"32.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":"4","RNA pig brain regional specific nTPM":{"amygdala":"74.9","cerebellum":"175.3","cerebral cortex":"136.6","hippocampal formation":"175.7"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"342239","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"36397921.9","Microglia and Neuropil":"45364038.9","Neurons":"20909784.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1","Protein tissue specific Intensity":{"cerebral cortex":"79157065.9"},"Antibody":["HPA077062"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":"Secreted in brain","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"370000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":10,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA077062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.23e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NPY5R","Gene synonym":["NPYR5"],"Ensembl":"ENSG00000164129","Gene description":"Neuropeptide Y receptor Y5","Uniprot":["Q15761"],"Chromosome":"4","Position":"163343892-163351934","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"6.7","lymphoid tissue":"8.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"16.1","Brain excitatory neurons":"4.1","Brain inhibitory neurons":"7.8","Epicardial cells":"2.3","Fibro-adipogenic progenitors":"2.2","Late primary spermatocytes":"8.2","Other brain neurons":"3.3","Pericytes":"2.8","Vascular smooth muscle cells":"2.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"16.1","Neuronal cells":"7.8","Spermatogenic cell types":"8.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"15.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"3.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bone cancer":"6.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.40e-6"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NR1H3","Gene synonym":["LXR-a","LXRa","RLD-1"],"Ensembl":"ENSG00000025434","Gene description":"Nuclear receptor subfamily 1 group H member 3","Uniprot":["Q13133"],"Chromosome":"11","Position":"47248300-47269033","Protein class":["Nuclear receptors","Plasma proteins","Predicted intracellular proteins","Transcription factors","Transporters"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"84.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"68.6","Hepatocytes":"72.0","Kupffer cells":"226.5","Late spermatids":"72.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"226.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"13.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 28: Liver & Adrenal gland - Secretion","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":29,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB037109":null,"HPA036443":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"}},{"Gene":"NR3C2","Gene synonym":["MLR","MR"],"Ensembl":"ENSG00000151623","Gene description":"Nuclear receptor subfamily 3 group C member 2","Uniprot":["P08235"],"Chromosome":"4","Position":"148078762-148444698","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Nuclear receptors","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Receptor"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"810.0","Distal convoluted tubule cells":"1221.3","Goblet cells":"857.5","Renal collecting duct intercalated cells":"1124.3","Renal connecting tubule cells":"1490.5","Somatotrophs":"1145.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"1490.5","Pituitary endocrine cells":"1145.4","Renal nephron cells":"1221.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"27.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"MAIT T-cell":"1.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"T-cells":"1.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB009155":null,"HPA074979":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.39e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.82e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.74e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - 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Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"35129.5","Microglia and Neuropil":"15545.9","Proximal tubules":"15040.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA000543","CAB010481"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":8,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB010481":null,"HPA000543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"}},{"Gene":"NRG1","Gene synonym":["GGF","HGL","HRG","NDF","NRG1-IT2"],"Ensembl":"ENSG00000157168","Gene description":"Neuregulin 1","Uniprot":["Q02297"],"Chromosome":"8","Position":"31639222-32855666","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"15.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"1244.5","Brain excitatory neurons":"1455.5","Brain inhibitory neurons":"1507.9","Cone photoreceptor cells":"1484.3","Gonadotrophs":"1913.2","Lactotrophs":"7015.1","Other brain neurons":"1174.1","Retinal bipolar cells":"1085.0","Retinal ganglion cells":"2008.6","Retinal horizontal cells":"4491.6","Somatotrophs":"1927.0","Thyrotrophs":"4198.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"4491.6","Pituitary endocrine cells":"7015.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"5760.1","lower rhombic lip":"10642.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"25.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"53.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"monocytes":"53.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA010964":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.48e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"}},{"Gene":"NRG3","Gene synonym":[],"Ensembl":"ENSG00000185737","Gene description":"Neuregulin 3","Uniprot":["P56975"],"Chromosome":"10","Position":"81875194-82987179","Protein class":["Cancer-related genes","Plasma proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"15.8","retina":"4.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"5328.1","Bergmann glia":"2901.0","Brain excitatory neurons":"3001.3","Brain inhibitory neurons":"2587.2","Choroid plexus epithelial cells":"1548.5","Corticotrophs":"3415.1","Ependymal cells":"3009.9","Fallopian secretory cells":"1487.7","Oligodendrocyte progenitor cells":"1468.0","Other brain neurons":"2880.5","Pituitary stem cells":"3416.9","Retinal amacrine cells":"2551.9","Retinal bipolar cells":"2194.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"3009.9","Glial cells":"5328.1","Neuronal cells":"3001.3","Pituitary endocrine cells":"3415.1","Stem cells":"3416.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"6.2","Skin Cutaneous Melanoma (TCGA)":"5.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"2.1","skin cancer":"2.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA075789":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NRG4","Gene synonym":["HRG4"],"Ensembl":"ENSG00000169752","Gene description":"Neuregulin 4","Uniprot":["Q8WWG1"],"Chromosome":"15","Position":"75935969-76059795","Protein class":["Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Growth factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.9","pancreas":"5.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"326.4","Foveolar cells":"113.6","Myonuclei":"126.0","Pancreatic acinar cells":"221.8","Prostatic glandular cells":"109.1","Respiratory ciliated cells":"132.2","Rod photoreceptor cells":"111.4","Salivary duct cells":"97.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"221.8","Ciliated cells":"326.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"359.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Skeletal muscle - Skeletal myocytes","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA010957"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to digestive system","Secretome function":"Growth factor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010957":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"}},{"Gene":"NRIP3","Gene synonym":["C11orf14"],"Ensembl":"ENSG00000175352","Gene description":"Nuclear receptor interacting protein 3","Uniprot":["Q9NQ35"],"Chromosome":"11","Position":"8965682-9005288","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"52.0","retina":"22.6","testis":"40.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"543.2","Late primary spermatocytes":"476.8","Late spermatids":"688.7","Retinal horizontal cells":"190.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"190.3","Spermatogenic cell types":"688.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"202.5","hippocampal CA4":"204.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"basophil":"13.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"granulocytes":"13.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"221620.3","Microglia and Neuropil":"318259.1","Neurons":"730023.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1856","Protein tissue specific Intensity":{"cerebral cortex":"185605.1"},"Antibody":["HPA058827","HPA072961"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":8,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA058827":null,"HPA072961":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"NRL","Gene synonym":["D14S46E","NRL-MAF","RP27"],"Ensembl":"ENSG00000129535","Gene description":"Neural retina leucine zipper","Uniprot":["P54845"],"Chromosome":"14","Position":"24078662-24115010","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Sensory transduction","Transcription","Transcription regulation","Vision"],"Molecular function":["Activator","Developmental protein","DNA-binding"],"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"73","RNA tissue specific nTPM":{"retina":"294.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"8.1","Bergmann glia":"9.3","Brain inhibitory neurons":"4.4","Choroid plexus epithelial cells":"5.8","Distal convoluted tubule cells":"9.9","Ependymal cells":"3.9","Loop of henle epithelial cells":"10.2","Microglia":"9.3","Oligodendrocyte progenitor cells":"5.4","Oligodendrocytes":"5.5","Other brain neurons":"4.7","Papillary tip epithelial cells":"8.6","Podocytes":"5.7","Proximal tubule cells":"12.5","Renal collecting duct intercalated cells":"10.5","Renal collecting duct principal cells":"12.3","Renal connecting tubule cells":"11.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Ciliated cells":"5.8","Ductal cells":"12.3","Glial cells":"9.3","Neuronal cells":"4.7","Renal nephron cells":"12.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Uterine cancer":"10.1"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB026066","HPA064599"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB026066":null,"HPA064599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":51,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA072545":null,"HPA073982":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.56e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1100000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":3,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA071400":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.42e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NRXN3","Gene synonym":["C14orf60","KIAA0743"],"Ensembl":"ENSG00000021645","Gene description":"Neurexin 3","Uniprot":["Q9HDB5","Q9Y4C0"],"Chromosome":"14","Position":"78170373-79868291","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Angiogenesis","Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"123.6","retina":"39.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"3164.4","Brain inhibitory neurons":"5645.6","Oligodendrocytes":"3111.2","Other brain neurons":"2871.5","Retinal amacrine cells":"3686.7","Retinal bipolar cells":"8389.3","Retinal horizontal cells":"3960.7","Schwann cells":"1856.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"3111.2","Neuronal cells":"8389.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"32.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"540000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA002727":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":66,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA043487":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.24e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.18e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"NSMCE1","Gene synonym":["NSE1"],"Ensembl":"ENSG00000169189","Gene description":"NSE1 homolog, SMC5-SMC6 complex component","Uniprot":["Q8WV22"],"Chromosome":"16","Position":"27224994-27268772","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"275.2","Late spermatids":"585.7","Mast cells":"240.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"585.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA041567":null,"HPA043091":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"}},{"Gene":"NSMCE3","Gene synonym":["HCA4","MAGEG1","MAGEL3","NDNL2","NSE3"],"Ensembl":"ENSG00000185115","Gene description":"NSE3 homolog, SMC5-SMC6 complex component","Uniprot":["Q96MG7"],"Chromosome":"15","Position":"29264989-29269822","Protein class":["Disease related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Growth regulation","Ubl conjugation pathway"],"Molecular function":["Tumor antigen"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2269660.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"744052.4","lung":"641754.0","lymphoid tissue":"236956.3"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA015593":null,"HPA015603":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028489":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"NSUN7","Gene synonym":["FLJ14001"],"Ensembl":"ENSG00000179299","Gene description":"NOP2\/Sun RNA methyltransferase family member 7","Uniprot":["Q8NE18"],"Chromosome":"4","Position":"40749925-40811184","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"15.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"131.5","Fallopian tube ciliated cells":"137.1","Late spermatids":"163.6","Neutrophils":"275.2","Respiratory ciliated cells":"366.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"366.2","Neutrophils":"275.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"93.0","ependymal cell":"140.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"13.6"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"15.6"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"2.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"2.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"3170279.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"276","Protein tissue specific Intensity":{"intestine":"27605.6"},"Antibody":["HPA020653"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA020653":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoli","Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Connecting piece","Mid piece"],"Antibody RRID":{"HPA056683":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046856":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NTAN1","Gene synonym":[],"Ensembl":"ENSG00000157045","Gene description":"N-terminal asparagine amidase","Uniprot":["Q96AB6"],"Chromosome":"16","Position":"15037854-15056079","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Kupffer cells":"42.0","Lymphatic endothelial cells":"48.1","Oocytes":"92.1","Platelets":"40.8","Urothelial cells":"36.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"92.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"17.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA051418":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-1"}},{"Gene":"NTMT1","Gene synonym":["AD-003","C9orf32","HOMT1A","METTL11A","NRMT","NRMT1"],"Ensembl":"ENSG00000148335","Gene description":"N-terminal Xaa-Pro-Lys N-methyltransferase 1","Uniprot":["Q9BV86"],"Chromosome":"9","Position":"129608884-129636135","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"417.0","Late primary spermatocytes":"361.9","Late spermatids":"1076.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1076.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2131590.9"},"Antibody":["HPA020092","HPA058420"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020092":null,"HPA058420":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.94e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"}},{"Gene":"NTN1","Gene synonym":["NET1","NTN1L"],"Ensembl":"ENSG00000065320","Gene description":"Netrin 1","Uniprot":["O95631"],"Chromosome":"17","Position":"9021510-9244000","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"35.5","heart muscle":"56.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"301.9","Epididymal clear cells":"249.0","Ocular epithelial cells":"218.8","Oligodendrocyte progenitor cells":"251.4","Renal collecting duct intercalated cells":"382.2","Respiratory basal cells":"534.7","Respiratory deuterosomal cells":"353.5","Respiratory ionocytes":"264.2","Respiratory secretory cells":"420.8","Salivary duct cells":"327.7","Smooth muscle cells":"260.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"534.7","Ductal cells":"382.2","Secretory cells":"420.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"205.6","ependymal cell":"189.7","oligodendrocyte precursor cell":"308.7","vascular associated smooth muscle cell":"205.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"39.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"22.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Breast - Fibroblasts","Prostate - Prostate basal glandular cells","Skin - Fibroblasts_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"5145","Protein cell type specific Intensity":{"Fallopian tube cells":"687545.6","Large ducts":"402122.6","Smooth muscle cells":"453748.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"23700","Protein tissue specific Intensity":{"blood vessel":"2376709.9","fallopian tube":"2363319.4"},"Antibody":["HPA056419"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Actin filaments","Cytosol"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2200000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Actin filaments"],"Antibody RRID":{"HPA056419":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"}},{"Gene":"NTRK3","Gene synonym":["TRKC"],"Ensembl":"ENSG00000140538","Gene description":"Neurotrophic receptor tyrosine kinase 3","Uniprot":["Q16288"],"Chromosome":"15","Position":"87859751-88256791","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein","Kinase","Receptor","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"blood vessel":"66.9","brain":"27.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"244.6","Astrocytes":"535.0","Bergmann glia":"667.1","Brain excitatory neurons":"469.7","Brain inhibitory neurons":"466.5","Early spermatids":"231.8","Late spermatids":"226.3","Oligodendrocyte progenitor cells":"830.2","Other brain neurons":"258.7","Retinal amacrine cells":"246.7","Retinal ganglion cells":"274.3","Vascular smooth muscle cells":"613.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"830.2","Mural cells":"613.8","Neuronal cells":"469.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"2426.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"22.8","Testicular Germ Cell Tumor (TCGA)":"9.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"7.1","Neuroblastoma":"7.8","thyroid cancer":"5.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Heart muscle - Smooth muscle cells","Skeletal muscle - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Smooth muscle cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"788055.2","Microglia and Neuropil":"2600584.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1886525.2"},"Antibody":["CAB009233","HPA027484","HPA048065"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane","Nucleoli","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"690000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":59,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"CAB009233":null,"HPA027484":null,"HPA048065":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.86e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NUB1","Gene synonym":["BS4","NUB1L","NYREN18"],"Ensembl":"ENSG00000013374","Gene description":"Negative regulator of ubiquitin like proteins 1","Uniprot":["Q9Y5A7"],"Chromosome":"7","Position":"151341772-151378449","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"212.6","Late primary spermatocytes":"393.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"393.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"2621201.6"},"Antibody":["HPA021220","HPA050722","HPA053648"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":19,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA021220":null,"HPA050722":null,"HPA053648":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.79e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.44e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.41e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"}},{"Gene":"NUCB2","Gene synonym":["NEFA"],"Ensembl":"ENSG00000070081","Gene description":"Nucleobindin 2","Uniprot":["P80303"],"Chromosome":"11","Position":"17208153-17349980","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["DNA-binding","Guanine-nucleotide releasing factor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"465.9","salivary gland":"478.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"804.5","Conjunctival goblet cells":"908.7","Early spermatids":"803.8","Epididymal principal cells":"1534.1","Esophageal apical cells":"3054.5","Respiratory deuterosomal cells":"824.1","Salivary acinar cells":"885.0","Syncytiotrophoblasts":"1906.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"3054.5","Reproductive supporting cells":"1534.1","Trophoblast cells":"1906.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Minor Salivary Gland - Minor salivary glandular cells","Pancreas - Exocrine glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"314343268.6","Pancreatic islets":"287805773.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"717760812.8"},"Antibody":["HPA008395","CAB015931","CAB079781"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Enhanced","Subcellular location":["Golgi apparatus"],"Secretome location":"Secreted to blood","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":1250000,"Blood concentration - Conc. blood MS [pg\/L]":"830000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":13,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB015931":null,"CAB079781":null,"HPA008395":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.72e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.92e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":40,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023183":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"52000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA012636":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.45e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.31e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.28e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.07e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.28e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.07e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"}},{"Gene":"NUDT21","Gene synonym":["CFIM25","CPSF5"],"Ensembl":"ENSG00000167005","Gene description":"Nudix hydrolase 21","Uniprot":["O43809"],"Chromosome":"16","Position":"56429133-56452199","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","mRNA processing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":65,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"HPA019863":null,"HPA074228":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.70e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.79e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.12e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.37e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"NUDT4","Gene synonym":["DIPP2","DIPP2alpha","DIPP2beta","HDCMB47P","KIAA0487"],"Ensembl":"ENSG00000173598","Gene description":"Nudix hydrolase 4","Uniprot":["Q9NZJ9"],"Chromosome":"12","Position":"93377883-93408146","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"590.9","Pituicytes\/FSCs":"252.2","Schwann cells":"237.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"590.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"122.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary gland ductal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"3702852.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"35012900.2"},"Antibody":["HPA017593","HPA047027","HPA057684"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017593":null,"HPA047027":null,"HPA057684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.30e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.63e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"}},{"Gene":"NUDT6","Gene synonym":["FGF-AS","FGF2AS","gfg","gfg-1"],"Ensembl":"ENSG00000170917","Gene description":"Nudix hydrolase 6","Uniprot":["P53370"],"Chromosome":"4","Position":"122888697-122922968","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"57.5","Late primary spermatocytes":"62.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"57.5","Spermatogenic cell types":"62.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"24656734.0","Proximal tubules":"14584092.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"8542683.9","kidney":"4402972.9","liver":"5913282.9"},"Antibody":["HPA039202","HPA066115"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039202":null,"HPA066115":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.23e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"}},{"Gene":"NUF2","Gene synonym":["CDCA1","CT106","NUF2R"],"Ensembl":"ENSG00000143228","Gene description":"NUF2 component of NDC80 kinetochore complex","Uniprot":["Q9BZD4"],"Chromosome":"1","Position":"163266576-163355764","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"26.8","lymphoid tissue":"24.2","testis":"50.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"194.3","Differentiating spermatogonia":"64.4","Early primary spermatocytes":"159.2","Epicardial cells":"113.7","Erythrocyte progenitors":"86.3","Late primary spermatocytes":"308.2","Monocyte progenitors":"89.6","Oocytes":"82.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"113.7","Myocytes":"194.3","Spermatogenic cell types":"308.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"4.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2441088.3","Neutrophils":"986171.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"727","Protein tissue specific Intensity":{"bone marrow":"72715.1"},"Antibody":["HPA059692","HPA076604"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Kinetochore","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":44,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Kinetochore","Cytosol"],"Antibody RRID":{"HPA059692":null,"HPA076604":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.80e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.05e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.44e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.81e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.33e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.05e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"}},{"Gene":"NUP155","Gene synonym":["KIAA0791","N155"],"Ensembl":"ENSG00000113569","Gene description":"Nucleoporin 155","Uniprot":["O75694"],"Chromosome":"5","Position":"37288137-37371106","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Atrial fibrillation","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"66.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"192.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"192.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037775"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"44000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":56,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA037775":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.61e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.62e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.77e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"}},{"Gene":"NUP188","Gene synonym":["KIAA0169"],"Ensembl":"ENSG00000095319","Gene description":"Nucleoporin 188","Uniprot":["Q5SRE5"],"Chromosome":"9","Position":"128947699-129007096","Protein class":["Disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Cataract","Disease variant","Microphthalmia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"81.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"20986652.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"1735976.4","Stomach":"1287472.4"},"Antibody":["HPA061750","HPA063942"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6700","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA061750":null,"HPA063942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.62e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"}},{"Gene":"NUP210L","Gene synonym":[],"Ensembl":"ENSG00000143552","Gene description":"Nucleoporin 210 like","Uniprot":["Q5VU65"],"Chromosome":"1","Position":"153992690-154155116","Protein class":["Cancer-related genes","Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"41","RNA tissue specific nTPM":{"testis":"24.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"56.0","Early primary spermatocytes":"107.5","Endometrial luminal cells":"82.8","Late primary spermatocytes":"54.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Luminal cells":"82.8","Spermatogenic cell types":"107.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"21993","Protein cell type specific Intensity":{"Skeletal myofibers":"2199276.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047195","HPA064245","HPA066707"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA047195":null,"HPA064245":null,"HPA066707":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NUP214","Gene synonym":["CAIN","CAN","D9S46E","N214"],"Ensembl":"ENSG00000126883","Gene description":"Nucleoporin 214","Uniprot":["P35658"],"Chromosome":"9","Position":"131125573-131234663","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"119.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"329.0","Late spermatids":"593.5","Neutrophils":"448.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"448.9","Spermatogenic cell types":"593.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"419.3","neutrophil":"1254.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1254.6","monocytes":"419.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":50,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"}},{"Gene":"NUP35","Gene synonym":["MP44"],"Ensembl":"ENSG00000163002","Gene description":"Nucleoporin 35","Uniprot":["Q8NFH5"],"Chromosome":"2","Position":"183117513-183161680","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"207.4","Late spermatids":"769.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"769.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":45,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA018401":null,"HPA018410":null,"HPA018441":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.70e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"}},{"Gene":"NUP42","Gene synonym":["CG1","H_RG271G13.9","hCG1","NLP_1","NUPL2"],"Ensembl":"ENSG00000136243","Gene description":"Nucleoporin 42","Uniprot":["O15504"],"Chromosome":"7","Position":"23181841-23201011","Protein class":["Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"332.6","Late primary spermatocytes":"201.5","Oligodendrocyte progenitor cells":"215.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"215.9","Spermatogenic cell types":"332.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":21,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA058084":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.94e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"15125542.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"19005272.4"},"Antibody":["HPA047162","HPA048328"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":50,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA047162":null,"HPA048328":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.64e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"}},{"Gene":"NUP58","Gene synonym":["KIAA0410","NUP45","NUPL1"],"Ensembl":"ENSG00000139496","Gene description":"Nucleoporin 58","Uniprot":["Q9BVL2"],"Chromosome":"13","Position":"25301524-25365390","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"400.4","Neutrophils":"626.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"626.4","Spermatogenic cell types":"400.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":91,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039360":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.19e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"}},{"Gene":"NUP62","Gene synonym":["DKFZp547L134","FLJ20822","FLJ43869","IBSN","MGC841","p62","SNDI"],"Ensembl":"ENSG00000213024","Gene description":"Nucleoporin 62","Uniprot":["P37198"],"Chromosome":"19","Position":"49906825-49929764","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"3.7","Early spermatids":"4.7","Epididymal clear cells":"2.0","Late primary spermatocytes":"9.3","Late spermatids":"6.9","Oocytes":"4.6","Thymic myoid cells":"1.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"4.6","Spermatogenic cell types":"9.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"11198683.2"},"Antibody":["HPA005435","CAB020724"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":147,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB020724":null,"HPA005435":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"}},{"Gene":"NUP88","Gene synonym":["MGC8530"],"Ensembl":"ENSG00000108559","Gene description":"Nucleoporin 88","Uniprot":["Q99567"],"Chromosome":"17","Position":"5359668-5420164","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"266.8","Late primary spermatocytes":"244.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"5560542.4"},"Antibody":["CAB002209","HPA021816"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4700","Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB002209":null,"HPA021816":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"}},{"Gene":"NUP98","Gene synonym":["NUP196","NUP96","Nup98-96","Nup98-Nup96"],"Ensembl":"ENSG00000110713","Gene description":"Nucleoporin 98 and 96 precursor","Uniprot":["P52948"],"Chromosome":"11","Position":"3671083-3797792","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Host-virus interaction","mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Neutrophils":"1824.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neutrophils":"1824.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"177252629.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6500","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":56,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - 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Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"22856","Protein cell type specific Intensity":{"Granulosa cells":"4011426.2","Neutrophils":"1580318.5","T-cells":"1265142.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"31237","Protein tissue specific Intensity":{"bone marrow":"3123695.6"},"Antibody":["HPA042904","HPA074847"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":14,"Subcellular main location":["Nucleoplasm","Nucleoli","Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA042904":null,"HPA074847":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.02e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.24e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.07e-12"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.10e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.96e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.24e-5"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"}},{"Gene":"NUTM1","Gene synonym":["C15orf55","DKFZp434O192","FAM22H","NUT"],"Ensembl":"ENSG00000184507","Gene description":"NUT midline carcinoma family member 1","Uniprot":["Q86Y26"],"Chromosome":"15","Position":"34343315-34357737","Protein class":["Cancer-related genes","Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"82","RNA tissue specific nTPM":{"testis":"18.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"43.4","Late primary spermatocytes":"101.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"101.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Gallbladder cancer":"1.9","head and neck cancer":"1.3"},"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040421":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NUTM2G","Gene synonym":["FAM22G"],"Ensembl":"ENSG00000188152","Gene description":"NUT family member 2G","Uniprot":["Q5VZR2"],"Chromosome":"9","Position":"96928310-96940253","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"2.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"21.1","Epicardial cells":"36.4","Retinal ganglion cells":"7.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"36.4","Myocytes":"21.1"},"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA064635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":null,"Subcellular main location":["Nucleoli","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA075476":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"}},{"Gene":"NXPE1","Gene synonym":["FAM55A","MGC34290"],"Ensembl":"ENSG00000095110","Gene description":"Neurexophilin and PC-esterase domain family member 1","Uniprot":["Q8N323"],"Chromosome":"11","Position":"114518934-114559881","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"intestine":"70.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Colonocytes":"535.4","Enteric stem cells":"307.9","Enteric transient amplifying cells":"276.8","Goblet cells":"586.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Enterocytes":"535.4","Goblet cells":"586.1","Proliferating cells":"276.8","Stem cells":"307.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"23","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"11.6","Rectum Adenocarcinoma (TCGA)":"10.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049133":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NXPH2","Gene synonym":["NPH2"],"Ensembl":"ENSG00000144227","Gene description":"Neurexophilin 2","Uniprot":["O95156"],"Chromosome":"2","Position":"138669157-138780390","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"brain":"4.1","kidney":"3.8","ovary":"4.1","retina":"2.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"81.0","Mesothelial cells":"21.8","Podocytes":"27.6","Renal collecting duct intercalated cells":"315.6","Respiratory ionocytes":"76.2","Retinal bipolar cells":"36.0","Salivary ionocytes":"49.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"315.6","Ionocytes":"76.2","Neuronal cells":"81.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"304.0","CGE interneuron":"192.4","deep-layer near-projecting":"354.8","LAMP5-LHX6 and Chandelier":"256.3","lower rhombic lip":"316.8","MGE interneuron":"187.7","midbrain-derived inhibitory":"252.5","splatter":"107.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"1.8"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"medulla oblongata":"15.6","midbrain":"16.2","pons":"27.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"3.6","Rhabdoid":"6.5"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034759":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"OARD1","Gene synonym":["C6orf130","dJ34B21.3","MGC19570","TARG1"],"Ensembl":"ENSG00000124596","Gene description":"O-acyl-ADP-ribose deacylase 1","Uniprot":["Q9Y530"],"Chromosome":"6","Position":"41033627-41097787","Protein class":["Disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"496.5","Late primary spermatocytes":"242.0","Late spermatids":"286.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"496.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":3,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA029036":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.05e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.96e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"}},{"Gene":"OASL","Gene synonym":["OASL1","p59OASL","TRIP14"],"Ensembl":"ENSG00000135114","Gene description":"2'-5'-oligoadenylate synthetase like","Uniprot":["Q15646"],"Chromosome":"12","Position":"121017763-121039246","Protein class":["Predicted intracellular proteins"],"Biological process":["Antiviral defense","Immunity","Innate immunity"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"33.7","stomach 1":"21.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"64.6","Esophageal apical cells":"110.1","Esophageal suprabasal cells":"32.2","Foveolar cells":"201.5","Goblet cells":"41.5","monocytes":"34.8","Neutrophils":"36.1","T-cells":"48.3","Urothelial cells":"78.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"110.1","Barrier epithelial cells":"78.6","Enterocytes":"64.6","Gastric glandular cells":"201.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"endothelial cell":"5.4","leukocyte":"21.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"133.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"pancreatic cancer":"43.2"},"RNA tissue cell type enrichment":["Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"5749320.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"7401","Protein tissue specific Intensity":{"lung":"1094234.1","lymphoid tissue":"385893.6"},"Antibody":["HPA001474"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":47,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA001474":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-3"}},{"Gene":"OCSTAMP","Gene synonym":["C20orf123","dJ257E24.3"],"Ensembl":"ENSG00000149635","Gene description":"Osteoclast stimulatory transmembrane protein","Uniprot":["Q9BR26"],"Chromosome":"20","Position":"46540946-46550654","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Differentiation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"1.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Myeloma":"4.7"},"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031116"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031116":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ODAD1","Gene synonym":["CCDC114","CILD20","FLJ32926"],"Ensembl":"ENSG00000105479","Gene description":"Outer dynein arm docking complex subunit 1","Uniprot":["Q96M63"],"Chromosome":"19","Position":"48296457-48321971","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"choroid plexus":"27.5","fallopian tube":"24.0","testis":"21.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"115.2","Endometrial ciliated cells":"95.5","Ependymal cells":"162.8","Epididymal efferent duct ciliated cells":"45.3","Fallopian tube ciliated cells":"124.7","Late primary spermatocytes":"31.2","Respiratory ciliated cells":"152.4","Respiratory deuterosomal cells":"25.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"162.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"43","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"126.7","ependymal cell":"177.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"5.6"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"61.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.7"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":11,"Subcellular main location":["Mid piece"],"Subcellular additional location":["Connecting piece","Principal piece"],"Antibody RRID":{"HPA042524":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.01e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"}},{"Gene":"ODAD2","Gene synonym":["ARMC4","CILD23","DKFZP434P1735","FLJ10376","FLJ10817","gudu"],"Ensembl":"ENSG00000169126","Gene description":"Outer dynein arm docking complex subunit 2","Uniprot":["Q5T2S8"],"Chromosome":"10","Position":"27775186-27999079","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"21.8","testis":"38.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"183.9","Early spermatids":"399.1","Endometrial ciliated cells":"204.4","Ependymal cells":"572.7","Epididymal efferent duct ciliated cells":"182.2","Fallopian tube ciliated cells":"353.1","Gonadotrophs":"211.7","Late primary spermatocytes":"352.9","Respiratory ciliated cells":"653.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"653.3","Pituitary endocrine cells":"211.7","Spermatogenic cell types":"399.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"20","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"188.9","ependymal cell":"624.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"4.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"7.1"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":11,"Subcellular main location":["End piece"],"Subcellular additional location":["Acrosome","Principal piece"],"Antibody RRID":{"HPA037829":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":20,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA054626":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"ODAD4","Gene synonym":["DKFZP434H0115","TTC25"],"Ensembl":"ENSG00000204815","Gene description":"Outer dynein arm docking complex subunit 4","Uniprot":["Q96NG3"],"Chromosome":"17","Position":"41930617-41966503","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"11.5","fallopian tube":"16.0","testis":"22.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"77.8","Early spermatids":"214.6","Endometrial ciliated cells":"97.9","Ependymal cells":"109.8","Epididymal efferent duct ciliated cells":"109.1","Fallopian tube ciliated cells":"195.2","Late primary spermatocytes":"307.9","Respiratory ciliated cells":"268.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"268.9","Spermatogenic cell types":"307.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"66.8","ependymal cell":"112.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":7,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Acrosome","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA023908":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":7,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB035996":null,"HPA001536":null,"HPA075384":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.59e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.50e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"ODF2","Gene synonym":["CT134","ODF84"],"Ensembl":"ENSG00000136811","Gene description":"Outer dense fiber of sperm tails 2","Uniprot":["Q5BJF6"],"Chromosome":"9","Position":"128455186-128501292","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"292.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"13180.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"110","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"13180.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":11,"Subcellular main location":["Primary cilium","Centrosome","Basal body","Connecting piece"],"Subcellular additional location":["Vesicles","Microtubules","Calyx","Mid piece","Principal piece"],"Antibody RRID":{"HPA001874":null,"HPA048841":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"}},{"Gene":"ODF3","Gene synonym":["CT135","hSHIPPO","SHIPPO1"],"Ensembl":"ENSG00000177947","Gene description":"Outer dense fiber of sperm tails 3","Uniprot":["Q96PU9"],"Chromosome":"11","Position":"196761-200261","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"19","RNA tissue specific nTPM":{"testis":"9.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"42","RNA single cell type specific nCPM":{"Early spermatids":"89.6","Late primary spermatocytes":"61.1","Late spermatids":"23.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"65","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"89.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":4,"Subcellular main location":["End piece"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA038919":null,"HPA039241":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ODF3L1","Gene synonym":["MGC48986"],"Ensembl":"ENSG00000182950","Gene description":"Outer dense fiber of sperm tails 3 like 1","Uniprot":["Q8IXM7"],"Chromosome":"15","Position":"75724041-75727688","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"21.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"86.9","Late primary spermatocytes":"117.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"117.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.36e-4"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ODF4","Gene synonym":["CT136","OPPO1"],"Ensembl":"ENSG00000184650","Gene description":"Outer dense fiber of sperm tails 4","Uniprot":["Q2M2E3"],"Chromosome":"17","Position":"8339840-8346048","Protein class":["Predicted membrane proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"124","RNA tissue specific nTPM":{"testis":"12.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"9.5","Early spermatids":"28.5","Esophageal apical cells":"13.6","Late primary spermatocytes":"115.4","Late spermatids":"46.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"115.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":20,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA072129":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA039448":null,"HPA040306":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"}},{"Gene":"OIP5","Gene synonym":["CT86","hMIS18beta","MIS18B"],"Ensembl":"ENSG00000104147","Gene description":"Opa interacting protein 5","Uniprot":["O43482"],"Chromosome":"15","Position":"41309273-41332591","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"9.7","skeletal muscle":"9.6","testis":"19.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"58.8","Differentiating spermatogonia":"92.3","Early primary spermatocytes":"108.1","Epicardial cells":"47.8","Late primary spermatocytes":"132.7","Myonuclei":"131.4","Oocytes":"101.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"131.4","Oocytes":"101.3","Spermatogenic cell types":"132.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3620","Protein cell type specific Intensity":{"Granulosa cells":"362032.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"121524","Protein tissue specific Intensity":{"bone marrow":"12152408.5"},"Antibody":["HPA052271","HPA059602"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":134,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA052271":null,"HPA059602":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"47000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1700000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":12,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035790":null,"HPA041443":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.43e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.35e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.20e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"OLAH","Gene synonym":["FLJ11106","SAST","THEDC1"],"Ensembl":"ENSG00000152463","Gene description":"Oleoyl-ACP hydrolase","Uniprot":["Q9NV23"],"Chromosome":"10","Position":"15032227-15073853","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid biosynthesis","Fatty acid metabolism","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"9.0","testis":"25.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"1784.9","Early spermatids":"694.0","Late primary spermatocytes":"278.3","Neutrophils":"635.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"28","RNA single cell type group specific nCPM":{"Neutrophils":"635.1","Secretory cells":"1784.9","Spermatogenic cell types":"694.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"5.9","fibroblast":"6.9","pericyte":"8.9","vascular associated smooth muscle cell":"7.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"8.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"2.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"2.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 4: Breast lactating luminal cells - Lactation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037947":null,"HPA037948":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"OLR1","Gene synonym":["CLEC8A","LOX-1","SCARE1"],"Ensembl":"ENSG00000173391","Gene description":"Oxidized low density lipoprotein receptor 1","Uniprot":["P78380"],"Chromosome":"12","Position":"10158301-10172138","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion","Immunity","Inflammatory response"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lung":"94.3","placenta":"107.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cytotrophoblasts":"590.9","Macrophages":"318.3","Microglia":"441.5","Migrating cytotrophoblasts":"288.4","monocytes":"615.5","Neutrophil progenitors":"192.1","Neutrophils":"172.8","Syncytiotrophoblasts":"572.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"441.5","Mononuclear phagocytes":"615.5","Neutrophils":"192.1","Trophoblast cells":"590.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"35","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"466.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"2.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"116.7","head and neck cancer":"80.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":4,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA050798":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"}},{"Gene":"OOEP","Gene synonym":["C6orf156","Em:AC019205.2","KHDC2"],"Ensembl":"ENSG00000203907","Gene description":"Oocyte expressed protein","Uniprot":["A6NGQ2"],"Chromosome":"6","Position":"73368555-73395133","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"13.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"771.2","Enteric stem cells":"1614.8","Enteric transient amplifying cells":"1261.5","Epididymal efferent duct absorptive cells":"714.2","Gastric chief cells":"1508.1","Goblet cells":"973.4","Mucous neck cells":"843.7","Paneth cells":"1086.7","Parietal cells":"1527.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"1527.5","Proliferating cells":"1261.5","Stem cells":"1614.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"25","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"33.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"3.9"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055165":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-1"}},{"Gene":"OPN3","Gene synonym":["ECPN","encephalopsin","ERO","NMO-1","PPP1R116"],"Ensembl":"ENSG00000054277","Gene description":"Opsin 3","Uniprot":["Q9H1Y3"],"Chromosome":"1","Position":"241590102-241677376","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":["Sensory transduction"],"Molecular function":["G-protein coupled receptor","Photoreceptor protein","Receptor","Retinal protein","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"17.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"115.7","Early spermatids":"197.8","Extravillous trophoblasts":"377.6","Late spermatids":"160.0","Migrating cytotrophoblasts":"142.3","pDCs":"172.3","Syncytiotrophoblasts":"187.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"172.3","Spermatogenic cell types":"197.8","Trophoblast cells":"377.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"plasmacytoid DC":"10.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"10.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Pituitary gland - Somatotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB013682","HPA049243"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":1,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane","Primary cilium","Basal body"],"Antibody RRID":{"CAB013682":null,"HPA049243":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-4"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.37e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"}},{"Gene":"OPN5","Gene synonym":["dJ402H5.1","neuropsin","TMEM13"],"Ensembl":"ENSG00000124818","Gene description":"Opsin 5","Uniprot":["Q6U736"],"Chromosome":"6","Position":"47781982-47832780","Protein class":["G-protein coupled receptors","Predicted membrane proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":["G-protein coupled receptor","Photoreceptor protein","Receptor","Retinal protein","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"2.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"32.9","Late primary spermatocytes":"49.7","Late spermatids":"48.5","Myosatellite cells":"30.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"49.7","Stem cells":"30.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"6.8","LAMP5-LHX6 and Chandelier":"9.0","mammillary body":"7.4","midbrain-derived inhibitory":"7.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026084":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":5,"Subcellular main location":["Primary cilium","Primary cilium tip"],"Subcellular additional location":null,"Antibody RRID":{"HPA064863":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.72e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"OPRM1","Gene synonym":["MOP","MOR1"],"Ensembl":"ENSG00000112038","Gene description":"Opioid receptor mu 1","Uniprot":["P35372"],"Chromosome":"6","Position":"154010496-154246867","Protein class":["FDA approved drug targets","G-protein coupled receptors","Human disease related genes","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.4","testis":"2.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"106.4","Brain excitatory neurons":"92.8","Brain inhibitory neurons":"102.1","Early spermatids":"70.1","Innate lymphoid cells":"48.2","Late primary spermatocytes":"74.3","Late spermatids":"76.5","Microglia":"152.3","NK-cells":"46.7","Other brain neurons":"100.3","Renal collecting duct intercalated cells":"41.0","T-cells":"69.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"106.4","Glial cells":"152.3","Neuronal cells":"102.1","Spermatogenic cell types":"76.5","T-cells":"69.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"374.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Neuroblastoma":"4.3"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":39,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014509":null,"HPA067435":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"OPTN","Gene synonym":["FIP-2","FIP2","GLC1E","HIP7","HYPL","NRP","TFIIIA-INTP"],"Ensembl":"ENSG00000123240","Gene description":"Optineurin","Uniprot":["Q96CV9"],"Chromosome":"10","Position":"13099449-13138308","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Autophagy","Host-virus interaction","Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":["Amyotrophic lateral sclerosis","Disease variant","Glaucoma","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skeletal muscle":"835.6","tongue":"368.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"444.3","Late spermatids":"1618.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1618.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2400000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":238,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB019303":null,"HPA003279":null,"HPA003360":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"}},{"Gene":"ORMDL2","Gene synonym":["adoplin-2","HSPC160","MST095","MSTP095"],"Ensembl":"ENSG00000123353","Gene description":"ORMDL sphingolipid biosynthesis regulator 2","Uniprot":["Q53FV1"],"Chromosome":"12","Position":"55818041-55821879","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"805.3","Esophageal suprabasal cells":"281.7","Late primary spermatocytes":"215.4","Syncytiotrophoblasts":"189.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"805.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"642501.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1382","Protein tissue specific Intensity":{"lymphoid tissue":"138210.0"},"Antibody":["HPA065643"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":20,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA065643":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.07e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.60e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"}},{"Gene":"OSBP2","Gene synonym":["KIAA1664","ORP-4","ORP4","OSBPL1"],"Ensembl":"ENSG00000184792","Gene description":"Oxysterol binding protein 2","Uniprot":["Q969R2"],"Chromosome":"22","Position":"30693782-30907824","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Lipid transport","Spermatogenesis","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"49.6","retina":"149.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"242.3","Early spermatids":"324.1","Late spermatids":"613.6","Oligodendrocytes":"283.4","Retinal amacrine cells":"230.5","Retinal bipolar cells":"258.3","Rod photoreceptor cells":"1448.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"1448.4","Spermatogenic cell types":"613.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"54.3"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Lactotropes","Spleen - Erythrocytes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"475241.5","B-cells":"340870.6","Macrophages":"601766.2","Microglia and Neuropil":"492404.0","Neurons":"999210.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"14785","Protein tissue specific Intensity":{"bone marrow":"1064089.4","cerebral cortex":"2362445.8","lymphoid tissue":"1008855.2"},"Antibody":["HPA021514"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":9,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021514":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.57e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.14e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.41e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"}},{"Gene":"OSCP1","Gene synonym":["C1orf102","NOR1"],"Ensembl":"ENSG00000116885","Gene description":"Organic solute carrier partner 1","Uniprot":["Q8WVF1"],"Chromosome":"1","Position":"36415827-36450451","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"79.1","testis":"72.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"436.4","Endometrial ciliated cells":"122.7","Epididymal efferent duct ciliated cells":"195.6","Fallopian tube ciliated cells":"227.5","Late primary spermatocytes":"542.4","Respiratory ciliated cells":"245.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"245.8","Spermatogenic cell types":"542.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"94.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"5597791.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1442666.2","fallopian tube":"4037500.9"},"Antibody":["HPA028436"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028436":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.73e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.86e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"}},{"Gene":"OSER1","Gene synonym":["C20orf111","dJ1183I21.1","HSPC207","Osr1","Perit1"],"Ensembl":"ENSG00000132823","Gene description":"Oxidative stress responsive serine rich 1","Uniprot":["Q9NX31"],"Chromosome":"20","Position":"44195939-44210771","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"900.2","Late primary spermatocytes":"609.7","Late spermatids":"3497.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3497.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045125"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Nucleoli rim","Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":["Nucleoli","Nucleoli rim","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA045125":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.75e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"}},{"Gene":"OSGIN2","Gene synonym":["C8orf1","hT41"],"Ensembl":"ENSG00000164823","Gene description":"Oxidative stress induced growth inhibitor family member 2","Uniprot":["Q9Y236"],"Chromosome":"8","Position":"89901849-89927888","Protein class":["Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"171.7","Early spermatids":"310.3","Late primary spermatocytes":"154.9","Late spermatids":"336.4","Pituicytes\/FSCs":"125.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"171.7","Spermatogenic cell types":"336.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"101.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"21.8","eosinophil":"7.0","neutrophil":"12.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"21.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"470","Protein cell type specific Intensity":{"Pancreatic islets":"47000.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028515","HPA050595"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA028515":null,"HPA050595":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.10e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.10e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.76e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"}},{"Gene":"OTOA","Gene synonym":["CT108","DFNB22"],"Ensembl":"ENSG00000155719","Gene description":"Otoancorin","Uniprot":["Q7RTW8"],"Chromosome":"16","Position":"21663968-21761935","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Hearing"],"Molecular function":null,"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"lymphoid tissue":"1.9","testis":"3.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"10.6","Hofbauer cells":"51.6","Kupffer cells":"38.9","Late primary spermatocytes":"6.7","Late spermatids":"12.5","Macrophages":"9.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"51.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"7.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"dendritic cells":"1.3"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Lung - Macrophages","Minor Salivary Gland - Macrophages","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"10745","Protein tissue specific Intensity":{"bone marrow":"1074484.9"},"Antibody":["HPA041405"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"33000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041405":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"OTOG","Gene synonym":["FLJ46346","mlemp","OTGN"],"Ensembl":"ENSG00000188162","Gene description":"Otogelin","Uniprot":["Q6ZRI0"],"Chromosome":"11","Position":"17547259-17647150","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pituitary gland":"1.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"48.7","Late spermatids":"40.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"48.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"2.3","hippocampal CA4":"3.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":22,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036623":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.82e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.96e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"}},{"Gene":"OTUD7B","Gene synonym":["CEZANNE","ZA20D1"],"Ensembl":"ENSG00000264522","Gene description":"OTU deubiquitinase 7B","Uniprot":["Q6GQQ9"],"Chromosome":"1","Position":"149937812-150010726","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Adaptive immunity","Immunity","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Melanocytes":"252.0","Oligodendrocytes":"251.3","Schwann cells":"246.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"354.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"2.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"1726125.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"11134866.5"},"Antibody":["HPA027045","HPA076357"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":29,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle"],"Antibody RRID":{"HPA027045":null,"HPA076357":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.96e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"}},{"Gene":"OVCH1","Gene synonym":["OVCH"],"Ensembl":"ENSG00000187950","Gene description":"Ovochymase 1","Uniprot":["Q7RTY7"],"Chromosome":"12","Position":"29412474-29497686","Protein class":["Enzymes","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lung":"1.4","testis":"1.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"21.3","Brain excitatory neurons":"20.5","Brain inhibitory neurons":"35.1","Early spermatids":"29.0","Epicardial cells":"29.6","Other brain neurons":"30.6","Retinal amacrine cells":"31.7","Vascular endothelial cells":"15.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"29.6","Neuronal cells":"35.1","Spermatogenic cell types":"29.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"OVGP1","Gene synonym":["CHIT5","MUC9"],"Ensembl":"ENSG00000085465","Gene description":"Oviductal glycoprotein 1","Uniprot":["Q12889"],"Chromosome":"1","Position":"111414319-111427735","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":["Fertilization"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"135","RNA tissue specific nTPM":{"fallopian tube":"1950.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"24","RNA single cell type specific nCPM":{"Fallopian secretory cells":"3283.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Secretory cells":"3283.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"40.4","Uterine Corpus Endometrial Carcinoma (TCGA)":"98.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Microtubules"],"Antibody RRID":{"HPA031666":null,"HPA062205":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"OVOL1","Gene synonym":["HOVO1"],"Ensembl":"ENSG00000172818","Gene description":"Ovo like transcriptional repressor 1","Uniprot":["O14753"],"Chromosome":"11","Position":"65787063-65797214","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"55.4","skin 1":"49.1","testis":"33.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast secretory cells":"143.1","Endometrial luminal cells":"162.7","Epididymal basal cells":"145.3","Esophageal apical cells":"604.2","Esophageal suprabasal cells":"233.0","Late primary spermatocytes":"191.9","Late spermatids":"137.8","Ocular epithelial cells":"158.3","Syncytiotrophoblasts":"392.4","Urothelial cells":"243.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"604.2","Barrier epithelial cells":"243.2","Suprabasal cells":"233.0","Trophoblast cells":"392.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA003984":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - 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Breast glandular cells","Breast - Breast glandular cells","Colon - Colon enterocytes","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Gonadotropes","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebral cortex":"10.3"},"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":"5","RNA pig brain regional specific nTPM":{"cerebral cortex":"5.3","hippocampal formation":"4.3"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038531"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":16,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA038531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.16e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"}},{"Gene":"OXLD1","Gene synonym":["C17orf90","MGC104712"],"Ensembl":"ENSG00000204237","Gene description":"Oxidoreductase like domain containing 1","Uniprot":["Q5BKU9"],"Chromosome":"17","Position":"81665036-81666635","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"191.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"191.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA056878":null,"HPA057019":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.58e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.39e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"OXNAD1","Gene synonym":["MGC15763"],"Ensembl":"ENSG00000154814","Gene description":"Oxidoreductase NAD binding domain containing 1","Uniprot":["Q96HP4"],"Chromosome":"3","Position":"16265160-16350299","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Innate lymphoid cells":"173.5","NK-cells":"186.3","T-cells":"335.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"T-cells":"335.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"322.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"81.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"T-cells":"81.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA036830":null,"HPA059160":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"}},{"Gene":"OXR1","Gene synonym":["TLDC3"],"Ensembl":"ENSG00000164830","Gene description":"Oxidation resistance 1","Uniprot":["Q8N573"],"Chromosome":"8","Position":"106270144-106752694","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Stress response"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Loop of henle epithelial cells":"1092.6","Microglia":"1319.2","Renal collecting duct intercalated cells":"1234.6","Retinal amacrine cells":"1346.0","Rod photoreceptor cells":"2238.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1319.2","Neuronal cells":"2238.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6500","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA027375":null,"HPA027380":null,"HPA027395":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.71e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.53e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"OXSM","Gene synonym":["CEM1","FASN2D","FLJ20604","KS"],"Ensembl":"ENSG00000151093","Gene description":"3-oxoacyl-ACP synthase, mitochondrial","Uniprot":["Q9NWU1"],"Chromosome":"3","Position":"25782917-25794534","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Fatty acid biosynthesis","Fatty acid metabolism","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cardiomyocytes":"268.3","Early spermatids":"167.8","Epicardial cells":"75.0","Late primary spermatocytes":"139.6","Late spermatids":"147.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"75.0","Myocytes":"268.3","Spermatogenic cell types":"167.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"10000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":5,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021293":null,"HPA021300":null,"HPA021337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.68e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.26e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"}},{"Gene":"PA2G4","Gene synonym":["EBP1"],"Ensembl":"ENSG00000170515","Gene description":"Proliferation-associated 2G4","Uniprot":["Q9UQ80"],"Chromosome":"12","Position":"56104537-56113910","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["rRNA processing","Transcription","Transcription regulation","Translation regulation"],"Molecular function":["Repressor","Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"404.8","Esophageal basal cells":"473.1","Late primary spermatocytes":"603.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"603.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB011711","CAB012428","HPA016484"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4900000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":79,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB011711":null,"CAB012428":null,"HPA016484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.70e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.74e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.50e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.91e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.04e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"}},{"Gene":"PABPC1","Gene synonym":["PAB1","PABP1","PABPC2","PABPL1"],"Ensembl":"ENSG00000070756","Gene description":"Poly(A) binding protein cytoplasmic 1","Uniprot":["P11940"],"Chromosome":"8","Position":"100685816-100722809","Protein class":["Cancer-related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","mRNA processing","mRNA splicing","Nonsense-mediated mRNA decay"],"Molecular function":["RNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"salivary gland":"1212.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"8505.5","Late primary spermatocytes":"2561.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"8505.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB011536","HPA045423","HPA067156"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2800000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":189,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB011536":null,"HPA045423":null,"HPA067156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.61e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.36e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.33e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.79e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"}},{"Gene":"PABPC3","Gene synonym":["PABP3","PABPL3","tPABP"],"Ensembl":"ENSG00000151846","Gene description":"Poly(A) binding protein cytoplasmic 3","Uniprot":["Q9H361"],"Chromosome":"13","Position":"25096136-25099254","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"142","RNA tissue specific nTPM":{"testis":"34.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late primary spermatocytes":"131.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"23","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"131.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"3.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"28069","Protein cell type specific Intensity":{"B-cells":"3169368.7","Skeletal myofibers":"2444363.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"825","Protein tissue specific Intensity":{"blood vessel":"82480.2"},"Antibody":["HPA045423","HPA067156"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":9,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045423":null,"HPA067156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PACRG","Gene synonym":["FLJ32724","Glup","HAK005771","PARK2CRG"],"Ensembl":"ENSG00000112530","Gene description":"Parkin coregulated","Uniprot":["Q96M98"],"Chromosome":"6","Position":"162727132-163315500","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"28.6","testis":"23.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"746.7","Choroid plexus epithelial cells":"636.1","Endometrial ciliated cells":"582.3","Ependymal cells":"1417.8","Epididymal clear cells":"1202.3","Fallopian tube ciliated cells":"743.0","Lactotrophs":"763.1","Late spermatids":"684.4","Renal collecting duct intercalated cells":"1764.0","Respiratory ciliated cells":"1762.1","Respiratory ionocytes":"825.5","Sertoli cells":"569.5","Somatotrophs":"1090.8","Thyrotrophs":"1032.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1762.1","Ductal cells":"1764.0","Ionocytes":"825.5","Pituitary endocrine cells":"1090.8","Reproductive supporting cells":"1202.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"1537.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"75.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Kidney - Intercalated cells","Liver - Hepatocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"224112","Protein cell type specific Intensity":{"Fallopian tube cells":"22411223.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1","Protein tissue specific Intensity":{"fallopian tube":"16248565.9"},"Antibody":["HPA066293"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":4,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA066293":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4137","Protein cell type specific Intensity":{"Fallopian tube cells":"413728.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054666"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":6,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA054666":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.86e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"}},{"Gene":"PACS1","Gene synonym":["FLJ10209","KIAA1175"],"Ensembl":"ENSG00000175115","Gene description":"Phosphofurin acidic cluster sorting protein 1","Uniprot":["Q6VY07"],"Chromosome":"11","Position":"66070272-66244744","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"875.4","Retinal horizontal cells":"849.4","Salivary acinar cells":"979.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"225930435.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"88468207.1","lymphoid tissue":"60300313.8","salivary gland":"25270265.8"},"Antibody":["HPA038914","HPA075046"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"10000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":12,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA038914":null,"HPA075046":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.88e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.02e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"PADI1","Gene synonym":["HPAD10","PAD1","PDI","PDI1"],"Ensembl":"ENSG00000142623","Gene description":"Peptidyl arginine deiminase 1","Uniprot":["Q9ULC6"],"Chromosome":"1","Position":"17205128-17246007","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"esophagus":"84.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"5.9","Loop of henle epithelial cells":"2.5","Microglia":"3.0","Other brain neurons":"1.1","Papillary tip epithelial cells":"11.1","Salivary duct cells":"1.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"5.9","Glial cells":"3.0","Renal nephron cells":"11.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"3.8","lower rhombic lip":"6.7","thalamic excitatory":"3.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"6.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Bile duct cancer":"14.6","colorectal cancer":"5.3","Gallbladder cancer":"19.4","ovarian cancer":"9.2","pancreatic cancer":"13.2"},"RNA tissue cell type enrichment":["Prostate - Urothelial cells","Skin - Inner root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"10443","Protein cell type specific Intensity":{"Keratinocytes":"1044333.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"143","Protein tissue specific Intensity":{"intestine":"14297.0"},"Antibody":["HPA062294"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA062294":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PAF1","Gene synonym":["F23149_1","FLJ11123","PD2"],"Ensembl":"ENSG00000006712","Gene description":"PAF1 homolog, Paf1\/RNA polymerase II complex component","Uniprot":["Q8N7H5"],"Chromosome":"19","Position":"39385629-39391154","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"157.3","Late primary spermatocytes":"137.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"157.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"8869265.6","Neutrophils":"7701446.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041875","HPA071954"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":79,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Vesicles"],"Antibody RRID":{"HPA041875":null,"HPA071954":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.74e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.38e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"}},{"Gene":"PAFAH1B1","Gene synonym":["LIS1","MDCR","MDS","NudF","PAFAH"],"Ensembl":"ENSG00000007168","Gene description":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1","Uniprot":["P43034"],"Chromosome":"17","Position":"2593210-2685615","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","Lipid degradation","Lipid metabolism","Mitosis","Neurogenesis","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"3382.9","Neutrophils":"947.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3382.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004489","HPA020036"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1300000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":85,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Mid piece"],"Antibody RRID":{"CAB004489":null,"HPA020036":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.16e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"}},{"Gene":"PAH","Gene synonym":["PH"],"Ensembl":"ENSG00000171759","Gene description":"Phenylalanine hydroxylase","Uniprot":["P00439"],"Chromosome":"12","Position":"102836889-102958410","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Phenylalanine catabolism"],"Molecular function":["Allosteric enzyme","Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant","FDA approved drug targets","Phenylketonuria"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"kidney":"463.6","liver":"1316.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"264.0","Corticotrophs":"102.3","Early spermatids":"184.7","Hepatocytes":"1063.0","Late primary spermatocytes":"143.2","Proximal tubule cells":"434.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"264.0","Hepatocytes":"1063.0","Renal nephron cells":"434.8","Spermatogenic cell types":"184.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"35.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"13","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"322.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"liver cancer":"43.8"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Colon enteroendocrine cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"190507481.7","Hepatocytes":"234686106.2","Proximal tubules":"262260520.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"129427127.4"},"Antibody":["HPA028407","HPA031642"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9900","Blood expression cluster":null,"Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":1,"Subcellular main location":["Endoplasmic reticulum","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA028407":null,"HPA031642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.17e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.57e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PAIP2","Gene synonym":["PAIP2A"],"Ensembl":"ENSG00000120727","Gene description":"Poly(A) binding protein interacting protein 2","Uniprot":["Q9BPZ3"],"Chromosome":"5","Position":"139341587-139369720","Protein class":["Predicted intracellular proteins"],"Biological process":["Translation regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"4607.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4607.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"3651","Protein cell type specific Intensity":{"Fallopian tube cells":"560471.8","Granulosa cells":"306158.7","Neurons":"290642.2","Oocytes":"204594.8","T-cells":"463800.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035945","CAB037212","HPA056766"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":20,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB037212":null,"HPA035945":null,"HPA056766":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"}},{"Gene":"PAIP2B","Gene synonym":["KIAA1155"],"Ensembl":"ENSG00000124374","Gene description":"Poly(A) binding protein interacting protein 2B","Uniprot":["Q9ULR5"],"Chromosome":"2","Position":"71182738-71227103","Protein class":["Predicted intracellular proteins"],"Biological process":["Translation regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"122.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"101.5","Esophageal apical cells":"117.7","Gastric chief cells":"127.8","Late primary spermatocytes":"158.9","Myonuclei":"102.0","Oocytes":"92.1","Pancreatic acinar cells":"320.0","Plasma cells":"98.2","Rod photoreceptor cells":"90.7","Salivary acinar cells":"136.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"320.0","Spermatogenic cell types":"158.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"46.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"4054508.2"},"Antibody":["HPA046784","HPA072371"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA046784":null,"HPA072371":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.39e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.55e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.76e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"}},{"Gene":"PALS2","Gene synonym":["MPP6","p55T","VAM-1"],"Ensembl":"ENSG00000105926","Gene description":"Protein associated with LIN7 2, MAGUK p55 family member","Uniprot":["Q9NZW5"],"Chromosome":"7","Position":"24573268-24694193","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"gallbladder":"17.9","testis":"23.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"677.8","Cone photoreceptor cells":"188.4","Pancreatic islet cells":"208.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"677.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"763.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"8.3"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"8.3","dendritic cells":"2.9","T-cells":"2.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Minor Salivary Gland - Endothelial cells","Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"30457200.5","Neurons":"43652522.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"86329049.7"},"Antibody":["HPA019085","HPA020456"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA019085":null,"HPA020456":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"}},{"Gene":"PANK2","Gene synonym":["C20orf48","FLJ11729","HARP","HSS","NBIA1","PKAN"],"Ensembl":"ENSG00000125779","Gene description":"Pantothenate kinase 2","Uniprot":["Q9BZ23"],"Chromosome":"20","Position":"3888839-3929887","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Angiogenesis","Coenzyme A biosynthesis"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"428.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"428.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"2902273.6"},"Antibody":["HPA008440"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":15,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.15e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.70e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"PAOX","Gene synonym":["PAO"],"Ensembl":"ENSG00000148832","Gene description":"Polyamine oxidase","Uniprot":["Q6QHF9"],"Chromosome":"10","Position":"133379261-133391694","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"27.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"3.1","Late spermatids":"3.9","Loop of henle epithelial cells":"5.1","Papillary tip epithelial cells":"7.5","Podocytes":"3.6","Proximal tubule cells":"7.8","Renal collecting duct intercalated cells":"5.7","Renal collecting duct principal cells":"9.6","Renal connecting tubule cells":"4.4","Tuft cells":"11.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ductal cells":"9.6","Renal nephron cells":"7.8","Secretory gland support":"11.5","Spermatogenic cell types":"3.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"732","Protein cell type specific Intensity":{"Proximal tubules":"73164.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"77664.5"},"Antibody":["HPA047782"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA047782":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"PAPOLB","Gene synonym":["PAPT"],"Ensembl":"ENSG00000218823","Gene description":"Poly(A) polymerase beta","Uniprot":["Q9NRJ5"],"Chromosome":"7","Position":"4857738-4862030","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing"],"Molecular function":["RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"101","RNA tissue specific nTPM":{"testis":"27.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"1.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047285":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"}},{"Gene":"PAQR5","Gene synonym":["FLJ20190","MPRG"],"Ensembl":"ENSG00000137819","Gene description":"Progestin and adipoQ receptor family member 5","Uniprot":["Q9NXK6"],"Chromosome":"15","Position":"69298912-69407780","Protein class":["Predicted membrane proteins"],"Biological process":["Differentiation","Oogenesis"],"Molecular function":["Developmental protein","Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"49.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"95.8","Distal convoluted tubule cells":"292.7","Esophageal apical cells":"83.0","Esophageal suprabasal cells":"80.5","Late spermatids":"226.3","Loop of henle epithelial cells":"208.1","Mast cells":"84.7","Pancreatic duct cells":"98.3","Proximal tubule cells":"136.7","Renal collecting duct intercalated cells":"196.3","Renal collecting duct principal cells":"80.2","Renal connecting tubule cells":"374.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"374.2","Renal nephron cells":"292.7","Spermatogenic cell types":"226.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"73.2","endothelial cell":"178.5","fibroblast":"49.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"32.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":6,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA076729":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.88e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.72e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.93e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.79e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - 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Cardiomyocytes","Pituitary gland - Corticotropes","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Spleen - Erythrocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"218806.6","Cardiomyocytes":"172022.8","Hepatocytes":"96888.9","Neurons":"252099.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"338624.5"},"Antibody":["HPA052798"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052798":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PARP6","Gene synonym":["ARTD17","pART17"],"Ensembl":"ENSG00000137817","Gene description":"Poly(ADP-ribose) polymerase family member 6","Uniprot":["Q2NL67"],"Chromosome":"15","Position":"72241181-72272999","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"310.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"310.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA026991":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.07e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"}},{"Gene":"PARP8","Gene synonym":["ARTD16","FLJ21308","pART16"],"Ensembl":"ENSG00000151883","Gene description":"Poly(ADP-ribose) polymerase family member 8","Uniprot":["Q8N3A8"],"Chromosome":"5","Position":"50665899-50846519","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"81.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Innate lymphoid cells":"612.5","Neutrophil progenitors":"717.1","Neutrophils":"1886.6","NK-cells":"1462.3","T-cells":"1713.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1886.6","NK-cells":"1462.3","T-cells":"1713.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"1862.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Breast - T-cells","Prostate - T-cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"15230","Protein tissue specific Intensity":{"intestine":"1522969.7"},"Antibody":["HPA049183"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Midbody ring","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Midbody ring","Cytosol"],"Antibody RRID":{"HPA049183":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"}},{"Gene":"PATE4","Gene synonym":["FLJ41047","PATE-B"],"Ensembl":"ENSG00000237353","Gene description":"Prostate and testis expressed 4","Uniprot":["P0C8F1"],"Chromosome":"11","Position":"125833316-125840072","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"seminal vesicle":"100.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Epididymal principal cells":"286.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"286.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"2.8","Kidney Renal Papillary Cell Carcinoma (TCGA)":"2.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"1.6"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045632"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045632":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.17e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.60e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PAX3","Gene synonym":["HUP2","PAX-3","WS1"],"Ensembl":"ENSG00000135903","Gene description":"Paired box 3","Uniprot":["P23760"],"Chromosome":"2","Position":"222199887-222298998","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Myogenesis","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":["Cancer-related genes","Deafness","Disease variant","Proto-oncogene","Waardenburg syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.7","salivary gland":"4.2","skeletal muscle":"3.4","skin 1":"2.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Bergmann glia":"663.4","Melanocytes":"374.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Glial cells":"663.4","Pigment cells":"374.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"Bergmann glia":"676.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"23","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"49.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"9.9","Sarcoma":"8.3","skin cancer":"23.0"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"7","RNA mouse brain regional specific nTPM":{"cerebellum":"3.4","midbrain":"1.4","pons and medulla":"1.3"},"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"9.7"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA063659","HPA069000"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA063659":null,"HPA069000":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PBK","Gene synonym":["CT84","FLJ14385","Nori-3","SPK","TOPK"],"Ensembl":"ENSG00000168078","Gene description":"PDZ binding kinase","Uniprot":["Q96KB5"],"Chromosome":"8","Position":"27809624-27838082","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"lymphoid tissue":"21.3","testis":"65.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"308.2","Late primary spermatocytes":"988.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"988.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"basal ganglia":"4.7","white matter":"13.9"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1579253.9","Oocytes":"1808878.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7286","Protein tissue specific Intensity":{"bone marrow":"728594.3"},"Antibody":["HPA005753","HPA050656"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":44,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA005753":null,"HPA050656":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.32e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.47e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.03e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.97e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.67e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.76e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"}},{"Gene":"PBX4","Gene synonym":[],"Ensembl":"ENSG00000105717","Gene description":"PBX homeobox 4","Uniprot":["Q9BYU1"],"Chromosome":"19","Position":"19561707-19618693","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"3.5","thyroid gland":"3.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"T-cells":"336.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"T-cells":"336.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"gdT-cell":"1.7","MAIT T-cell":"1.7","memory CD4 T-cell":"1.2","memory CD8 T-cell":"1.9","naive CD4 T-cell":"1.2","naive CD8 T-cell":"1.0","T-reg":"3.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"T-cells":"3.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"4.1"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":69,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049859":null,"HPA056469":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PC","Gene synonym":["PCB"],"Ensembl":"ENSG00000173599","Gene description":"Pyruvate carboxylase","Uniprot":["P11498"],"Chromosome":"11","Position":"66848417-66958386","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Gluconeogenesis","Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Ligase","Multifunctional enzyme"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"182.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"252.6","Hepatocytes":"250.1","Lacrimal acinar cells":"97.8","Late spermatids":"89.6","Proximal tubule cells":"104.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"252.6","Hepatocytes":"250.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"63.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Prostate - Prostate glandular cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"585381310.2","Proximal tubules":"994076096.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"427880240.8"},"Antibody":["CAB033742","HPA043922","HPA058765","HPA070392"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"180000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":14,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB033742":null,"HPA043922":null,"HPA058765":null,"HPA070392":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.68e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.67e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"}},{"Gene":"PCBP3","Gene synonym":["FLJ44028","PCBP3-OT1","PCBP3OT"],"Ensembl":"ENSG00000183570","Gene description":"Poly(rC) binding protein 3","Uniprot":["P57721"],"Chromosome":"21","Position":"45643694-45942454","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding","Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"59.3","retina":"75.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"1289.7","Corticotrophs":"568.8","Early primary spermatocytes":"415.8","Retinal amacrine cells":"402.2","Retinal bipolar cells":"741.8","Retinal ganglion cells":"633.5","Retinal horizontal cells":"414.7","Rod photoreceptor cells":"1187.2","Thymocytes":"418.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"1289.7","Pituitary endocrine cells":"568.8","Spermatogenic cell types":"415.8","T-cells":"418.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"1029.0","pericyte":"591.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"3.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"37.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pituitary gland - Corticotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"olfactory bulb":"229.2"},"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"olfactory bulb":"111.2"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"3292363.9","Oocytes":"928173.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"336","Protein tissue specific Intensity":{"bone marrow":"15547.7","cerebral cortex":"28860.5","intestine":"28738.3","lymphoid tissue":"61138.8"},"Antibody":["HPA030247","HPA073145"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Vesicles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":7,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA030247":null,"HPA073145":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.00e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.45e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.99e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"}},{"Gene":"PCDH10","Gene synonym":["KIAA1400","OL-PCDH"],"Ensembl":"ENSG00000138650","Gene description":"Protocadherin 10","Uniprot":["Q9P2E7"],"Chromosome":"4","Position":"133149294-133208606","Protein class":["Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"blood vessel":"19.1","brain":"35.0","placenta":"24.3","prostate":"10.0","seminal vesicle":"16.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"74.6","Brain excitatory neurons":"39.7","Brain inhibitory neurons":"108.7","Corticotrophs":"44.3","Endometrial luminal cells":"85.2","Epididymal efferent duct absorptive cells":"131.8","Epididymal efferent duct ciliated cells":"42.8","Oligodendrocyte progenitor cells":"69.0","Oligodendrocytes":"121.6","Other brain neurons":"79.4","Schwann cells":"41.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"131.8","Glial cells":"121.6","Luminal cells":"85.2","Neuronal cells":"108.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"18.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"44.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Adrenal gland - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"27205","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3327713.6","Microglia and Neuropil":"2774697.9","Neurons":"2059133.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"15463216.9","kidney":"7903084.6","liver":"4129949.7"},"Antibody":["HPA011220","HPA073462"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":7,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA011220":null,"HPA073462":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"}},{"Gene":"PCDH15","Gene synonym":["CDHR15","DFNB23","USH1F"],"Ensembl":"ENSG00000150275","Gene description":"Protocadherin related 15","Uniprot":["Q96QU1"],"Chromosome":"10","Position":"53802771-55627942","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion","Hearing"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness","Retinitis pigmentosa","Usher syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"adrenal gland":"17.9","retina":"57.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"1026.5","Cone photoreceptor cells":"1968.7","Lactotrophs":"1040.0","Oligodendrocyte progenitor cells":"4341.5","Pituicytes\/FSCs":"3767.3","Proximal tubule cells":"650.3","Rod photoreceptor cells":"2705.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"1026.5","Glial cells":"4341.5","Neuronal cells":"2705.9","Pituitary endocrine cells":"1040.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"4937.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"5.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"6.3"},"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Kidney - Proximal tubular cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029460","HPA064488","HPA074437"],"Reliability (IH)":null,"Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Vesicles","Plasma membrane","Focal adhesion sites"],"Secretome location":"Intracellular and membrane","Secretome function":"Cell adhesion","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus","Focal adhesion sites"],"Antibody RRID":{"HPA029460":null,"HPA064488":null,"HPA074437":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":2,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA026817":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.40e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.60e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6500","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytokinetic bridge"],"Antibody RRID":{"HPA062669":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PCDH8","Gene synonym":["ARCADLIN","PAPC"],"Ensembl":"ENSG00000136099","Gene description":"Protocadherin 8","Uniprot":["O95206"],"Chromosome":"13","Position":"52842889-52848641","Protein class":["Plasma proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"brain":"12.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal prostatic cells":"6.3","Brain excitatory neurons":"15.8","Brain inhibitory neurons":"28.7","Late primary spermatocytes":"5.5","M\u00fcller glia":"25.6","Other brain neurons":"24.6","Prostatic club cells":"7.9","Retinal amacrine cells":"5.8","Retinal bipolar cells":"13.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"7.9","Glial cells":"25.6","Neuronal cells":"28.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"75.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"4.6","Neuroblastoma":"2.4"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010509":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":null,"Interactions":null,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA008755":null,"HPA010580":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PCGF1","Gene synonym":["MGC10882","NSPC1","RNF68"],"Ensembl":"ENSG00000115289","Gene description":"Polycomb group ring finger 1","Uniprot":["Q9BSM1"],"Chromosome":"2","Position":"74505043-74507695","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"30.7","Late primary spermatocytes":"36.4","Oocytes":"50.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"50.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":47,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA011356":null,"HPA069156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"PCGF5","Gene synonym":["MGC16202","RNF159"],"Ensembl":"ENSG00000180628","Gene description":"Polycomb group ring finger 5","Uniprot":["Q86SE9"],"Chromosome":"10","Position":"91163012-91284337","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"633.5","Platelets":"524.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":50,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA038349":null,"HPA059071":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"}},{"Gene":"PCID2","Gene synonym":["FLJ11305"],"Ensembl":"ENSG00000126226","Gene description":"PCI domain containing 2","Uniprot":["Q5JVF3"],"Chromosome":"13","Position":"113177536-113208715","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"296.7","Oocytes":"303.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Oocytes":"303.9","Spermatogenic cell types":"296.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"13197712.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1842576.9","lymphoid tissue":"465317.8"},"Antibody":["HPA069107","HPA073074"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA069107":null,"HPA073074":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.83e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.29e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.35e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"PCK2","Gene synonym":["PEPCK","PEPCK2"],"Ensembl":"ENSG00000100889","Gene description":"Phosphoenolpyruvate carboxykinase 2, mitochondrial","Uniprot":["Q16822"],"Chromosome":"14","Position":"24094053-24110598","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Gluconeogenesis"],"Molecular function":["Decarboxylase","Lyase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"intestine":"184.6","kidney":"92.5","liver":"366.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"11.8","Enterocytes":"41.1","Epididymal efferent duct absorptive cells":"8.3","Hepatocytes":"13.5","Late primary spermatocytes":"12.3","Microglia":"7.7","Paneth cells":"7.7","Papillary tip epithelial cells":"8.0","Proximal tubule cells":"41.0","Renal collecting duct principal cells":"8.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"41.1","Hepatocytes":"13.5","Renal nephron cells":"41.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"109.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Heart muscle - Macrophages","Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"2149390984.5","Proximal tubules":"2695136619.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"1376508032.4"},"Antibody":["CAB018734","HPA051162","HPA053502"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2400000","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB018734":null,"HPA051162":null,"HPA053502":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.62e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"}},{"Gene":"PCM1","Gene synonym":["PTC4"],"Ensembl":"ENSG00000078674","Gene description":"Pericentriolar material 1","Uniprot":["Q15154"],"Chromosome":"8","Position":"17922842-18029948","Protein class":["Cancer-related genes","Disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"28422983.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023370","HPA023374","CAB058695"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Primary cilium","Centriolar satellite","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":189,"Subcellular main location":["Microtubules","Primary cilium","Centriolar satellite","Basal body"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB058695":null,"HPA023370":null,"HPA023374":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.16e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"}},{"Gene":"PCMT1","Gene synonym":[],"Ensembl":"ENSG00000120265","Gene description":"Protein-L-isoaspartate (D-aspartate) O-methyltransferase","Uniprot":["P22061"],"Chromosome":"6","Position":"149749444-149811420","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1214.2","Late primary spermatocytes":"414.6","Late spermatids":"616.2","Neutrophil progenitors":"536.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1214.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003239"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2200000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":23,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA003239":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.19e-7"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.23e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.96e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.67e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.85e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.76e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"}},{"Gene":"PCNA","Gene synonym":[],"Ensembl":"ENSG00000132646","Gene description":"Proliferating cell nuclear antigen","Uniprot":["P12004"],"Chromosome":"20","Position":"5114953-5126626","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","DNA replication","Host-virus interaction"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes","Deafness","Disease variant","Dwarfism","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"361.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"191.3","Early spermatids":"233.2","Erythrocyte progenitors":"361.4","Esophageal basal cells":"217.0","Late primary spermatocytes":"240.5","Migrating cytotrophoblasts":"238.2","Monocyte progenitors":"236.8","Oocytes":"492.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"361.4","Oocytes":"492.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Pancreas - Macrophages","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"29533427.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"104777323.4"},"Antibody":["CAB000148","HPA030521","HPA030522","HPA030523","CAB080239","CAB080240","CAB080241","CAB080242"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":245,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB000148":null,"CAB080239":null,"CAB080240":null,"CAB080241":null,"CAB080242":null,"HPA030521":null,"HPA030522":null,"HPA030523":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.61e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.43e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"PCSK4","Gene synonym":["DKFZp434B217","MGC34749","PC4","SPC5"],"Ensembl":"ENSG00000115257","Gene description":"Proprotein convertase subtilisin\/kexin type 4","Uniprot":["Q6UW60"],"Chromosome":"19","Position":"1481428-1490752","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"62.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1192.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"30","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1192.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"39.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005572"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA005572":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-1"}},{"Gene":"PCYT2","Gene synonym":["ET"],"Ensembl":"ENSG00000185813","Gene description":"Phosphate cytidylyltransferase 2, ethanolamine","Uniprot":["Q99447"],"Chromosome":"17","Position":"81900958-81911432","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"163.1","testis":"248.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"5103.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5103.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"58287701.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"61753843.9"},"Antibody":["HPA023033","HPA023034"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"86000","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":8,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023033":null,"HPA023034":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"}},{"Gene":"PDCD2L","Gene synonym":["MGC13096"],"Ensembl":"ENSG00000126249","Gene description":"Programmed cell death 2 like","Uniprot":["Q9BRP1"],"Chromosome":"19","Position":"34404399-34426168","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"24.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"54.0","Early primary spermatocytes":"33.3","Gastric progenitor cells":"46.1","Late primary spermatocytes":"58.0","Oocytes":"156.6","Undifferentiated spermatogonia":"29.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Oocytes":"156.6","Proliferating cells":"46.1","Spermatogenic cell types":"58.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":11,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA052181":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"140000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":25,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA018471":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.17e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.76e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.03e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"}},{"Gene":"PDCL2","Gene synonym":["GCPHLP"],"Ensembl":"ENSG00000163440","Gene description":"Phosducin like 2","Uniprot":["Q8N4E4"],"Chromosome":"4","Position":"55556519-55592245","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"206","RNA tissue specific nTPM":{"testis":"61.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"17","RNA single cell type specific nCPM":{"Early spermatids":"1630.0","Late primary spermatocytes":"529.8","Late spermatids":"904.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"141","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1630.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"MGE interneuron":"8.6","thalamic excitatory":"5.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"2.5","Testicular Germ Cell Tumor (TCGA)":"4.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA048260":null,"HPA072384":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.93e-5"}},{"Gene":"PDE10A","Gene synonym":[],"Ensembl":"ENSG00000112541","Gene description":"Phosphodiesterase 10A","Uniprot":["Q9Y233"],"Chromosome":"6","Position":"165327287-165988117","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Allosteric enzyme","Hydrolase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"719.9","Brain inhibitory neurons":"1309.7","Gonadotrophs":"1729.9","Lactotrophs":"2978.6","M\u00fcller glia":"1479.4","Somatotrophs":"2292.9","Urothelial cells":"1613.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1613.2","Glial cells":"1479.4","Neuronal cells":"1309.7","Pituitary endocrine cells":"2978.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"3075.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"basal ganglia":"147.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"21.3"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB045998":null,"HPA047200":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":null,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Nucleoplasm","Cytokinetic bridge","Mitotic spindle","Centriolar satellite","Basal body","Cytosol"],"Antibody RRID":{"HPA034560":null,"HPA034561":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA022151":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021751":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"449589.1","Pancreatic islets":"1255649.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3507","Protein tissue specific Intensity":{"liver":"350748.1"},"Antibody":["HPA056111"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":18,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA056111":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"}},{"Gene":"PDE6A","Gene synonym":["PDEA","RP43"],"Ensembl":"ENSG00000132915","Gene description":"Phosphodiesterase 6A","Uniprot":["P16499"],"Chromosome":"5","Position":"149857953-149944793","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"65","RNA tissue specific nTPM":{"retina":"1001.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"24","RNA single cell type specific nCPM":{"Rod photoreceptor cells":"6364.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"69","RNA single cell type group specific nCPM":{"Neuronal cells":"6364.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016970":null,"HPA074677":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PDE6D","Gene synonym":["JBTS22"],"Ensembl":"ENSG00000156973","Gene description":"Phosphodiesterase 6D","Uniprot":["O43924"],"Chromosome":"2","Position":"231732433-231786272","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Ciliopathy","Joubert syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"224.0","Early spermatids":"173.9","Late primary spermatocytes":"417.2","Late spermatids":"218.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"417.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":48,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA037433":null,"HPA037434":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"}},{"Gene":"PDHA2","Gene synonym":["PDHAL"],"Ensembl":"ENSG00000163114","Gene description":"Pyruvate dehydrogenase E1 subunit alpha 2","Uniprot":["P29803"],"Chromosome":"4","Position":"95840093-95841464","Protein class":["Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism","Glucose metabolism","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"563","RNA tissue specific nTPM":{"testis":"56.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"25","RNA single cell type specific nCPM":{"Early spermatids":"370.6","Late primary spermatocytes":"666.6","Late spermatids":"362.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"138","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"666.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA047487":null,"HPA047864":null,"HPA063053":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041913":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":40,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB017554":null,"HPA027376":null,"HPA059083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"}},{"Gene":"PDP1","Gene synonym":["PDH","PDP","PPM2A","PPM2C"],"Ensembl":"ENSG00000164951","Gene description":"Pyruvate dehydrogenase phosphatase catalytic subunit 1","Uniprot":["Q9P0J1"],"Chromosome":"8","Position":"93857807-93926068","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"165.4","Cardiomyocytes":"107.2","Early spermatids":"177.8","Endometrial glandular cells":"93.3","Ocular epithelial cells":"90.6","Salivary duct cells":"95.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"165.4","Spermatogenic cell types":"177.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":8,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles","Mitochondria"],"Antibody RRID":{"HPA018483":null,"HPA019081":null,"HPA021152":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.63e-5"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"}},{"Gene":"PDRG1","Gene synonym":["C20orf126","dJ310O13.3"],"Ensembl":"ENSG00000088356","Gene description":"P53 and DNA damage regulated 1","Uniprot":["Q9NUG6"],"Chromosome":"20","Position":"31944337-31952046","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"65.1","Late primary spermatocytes":"92.9","Oocytes":"78.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"92.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"465096.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"3091773.7"},"Antibody":["HPA047084","HPA063542"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Actin filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":83,"Subcellular main location":["Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA047084":null,"HPA063542":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.71e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"}},{"Gene":"PDSS1","Gene synonym":["COQ1","COQ1A","TPRT","TPT"],"Ensembl":"ENSG00000148459","Gene description":"Decaprenyl diphosphate synthase subunit 1","Uniprot":["Q5T2R2"],"Chromosome":"10","Position":"26697701-26746798","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Isoprene biosynthesis","Lipid metabolism","Ubiquinone biosynthesis"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"18.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Monocyte progenitors":"74.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"1981728.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"23","Protein tissue specific Intensity":{"intestine":"1868.0","kidney":"2655.4"},"Antibody":["HPA038032","HPA042741"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038032":null,"HPA042741":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.10e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.71e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.04e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.33e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"}},{"Gene":"PDXDC1","Gene synonym":["KIAA0251"],"Ensembl":"ENSG00000179889","Gene description":"Pyridoxal dependent decarboxylase domain containing 1","Uniprot":["Q6P996"],"Chromosome":"16","Position":"14974591-15139339","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Decarboxylase","Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"135.3","Distal convoluted tubule cells":"150.5","Early spermatids":"209.7","Late spermatids":"360.6","Loop of henle epithelial cells":"168.2","Papillary tip epithelial cells":"184.6","Podocytes":"194.9","Proximal tubule cells":"162.0","Renal collecting duct intercalated cells":"163.6","Renal collecting duct principal cells":"154.7","Renal connecting tubule cells":"156.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"163.6","Renal nephron cells":"194.9","Spermatogenic cell types":"360.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"102589883.8","Pancreas epithelial cells":"74890770.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"307471397.2","salivary gland":"83060350.6"},"Antibody":["HPA047369","HPA049121","HPA051484"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":36,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA047369":null,"HPA049121":null,"HPA051484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"PDXK","Gene synonym":["C21orf124","C21orf97","FLJ21324","FLJ31940","MGC15873","PKH","PNK","PRED79"],"Ensembl":"ENSG00000160209","Gene description":"Pyridoxal kinase","Uniprot":["O00764"],"Chromosome":"21","Position":"43719094-43762307","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Transferase"],"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","FDA approved drug targets","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"73.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1661.7","Late primary spermatocytes":"2136.5","Late spermatids":"6953.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6953.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"381.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"141710569.7"},"Antibody":["HPA030196","HPA030197","HPA030198","CAB033918"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"490000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB033918":null,"HPA030196":null,"HPA030197":null,"HPA030198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.37e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"}},{"Gene":"PDYN","Gene synonym":["ADCA","PENKB","SCA23"],"Ensembl":"ENSG00000101327","Gene description":"Prodynorphin","Uniprot":["P01213"],"Chromosome":"20","Position":"1978757-1994285","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted secreted proteins","Transporters"],"Biological process":null,"Molecular function":["Endorphin","Neuropeptide","Neurotransmitter","Opioid peptide"],"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"brain":"125.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"49.0","Late spermatids":"178.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"178.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"39.2","hippocampal dentate gyrus":"25.4","medium spiny neuron":"25.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"20","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"5.2","Ovary Serous Cystadenocarcinoma (TCGA)":"2.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"12","RNA cell line specific nTPM":{"Bone cancer":"3.9"},"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"basal ganglia":"152.2","hypothalamus":"60.7"},"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"basal ganglia":"173.9"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053342","CAB079777"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in brain","Secretome function":"Neuropeptide","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB079777":null,"HPA053342":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PDZD8","Gene synonym":["bA129M16.2","FLJ34427","PDZK8"],"Ensembl":"ENSG00000165650","Gene description":"PDZ domain containing 8","Uniprot":["Q8NEN9"],"Chromosome":"10","Position":"117277274-117375440","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Host-virus interaction","Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Autism spectrum disorder","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"68.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"438.8","Late spermatids":"882.0","Megakaryocyte progenitors":"487.3","Megakaryocyte-Erythroid progenitors":"1099.2","Neutrophil progenitors":"1267.1","Neutrophils":"671.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"1099.2","Neutrophils":"1267.1","Spermatogenic cell types":"882.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1197021.4","lung":"3664830.1"},"Antibody":["HPA015716","HPA051610"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":52,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA015716":null,"HPA051610":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.73e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"}},{"Gene":"PDZD9","Gene synonym":["C16orf65","MGC50721"],"Ensembl":"ENSG00000155714","Gene description":"PDZ domain containing 9","Uniprot":["Q8IXQ8"],"Chromosome":"16","Position":"21983865-22001116","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"10.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"2.7","Bergmann glia":"4.0","Brain excitatory neurons":"4.8","Brain inhibitory neurons":"4.5","Early spermatids":"3.3","Late primary spermatocytes":"5.5","Late spermatids":"10.6","Loop of henle epithelial cells":"3.1","Oligodendrocyte progenitor cells":"2.7","Oligodendrocytes":"1.5","Other brain neurons":"3.2","Renal collecting duct principal cells":"1.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"4.0","Neuronal cells":"4.8","Renal nephron cells":"3.1","Spermatogenic cell types":"10.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042457"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Plasma membrane","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nuclear speckles","Primary cilium"],"Antibody RRID":{"HPA042457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PEBP4","Gene synonym":["CORK1","hPEBP4","MGC22776"],"Ensembl":"ENSG00000134020","Gene description":"Phosphatidylethanolamine binding protein 4","Uniprot":["Q96S96"],"Chromosome":"8","Position":"22713251-23000000","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"361.1","skeletal muscle":"628.6","tongue":"542.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"302.1","Alveolar cells type 2":"857.4","Epididymal principal cells":"967.8","Late spermatids":"170.1","M\u00fcller glia":"268.8","Myonuclei":"1086.2","Prostatic glandular cells":"170.0","Transitional alveolar cells":"435.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"857.4","Myocytes":"1086.2","Reproductive supporting cells":"967.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"97.3","ependymal cell":"82.2"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"42.4","Prostate Adenocarcinoma (TCGA)":"55.9","Thyroid Carcinoma (TCGA)":"84.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"prostate cancer":"9.4"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Lung - Alveolar cells type 2","Prostate - Prostate glandular cells","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"2212459.0","Glomeruli":"4976446.8","Oocytes":"2429627.0","Proximal tubules":"6299100.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"11890558.8","skeletal muscle":"5301161.6"},"Antibody":["HPA025064"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"39000000","Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA025064":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"}},{"Gene":"PELO","Gene synonym":[],"Ensembl":"ENSG00000152684","Gene description":"Pelota mRNA surveillance and ribosome rescue factor","Uniprot":["Q9BRX2"],"Chromosome":"5","Position":"52787916-52804044","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Translation regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Gastric chief cells":"2.2","Hepatic stellate cells":"6.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Gastric glandular cells":"2.2","Stellate cells":"6.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":33,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Nucleoplasm","Mitotic chromosome"],"Antibody RRID":{"HPA031458":null,"HPA073228":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.38e-5"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.74e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"}},{"Gene":"PENK","Gene synonym":[],"Ensembl":"ENSG00000181195","Gene description":"Proenkephalin","Uniprot":["P01210"],"Chromosome":"8","Position":"56436674-56446671","Protein class":["Plasma proteins","Predicted secreted proteins","Transporters"],"Biological process":null,"Molecular function":["Endorphin","Neuropeptide","Opioid peptide"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"adrenal gland":"355.7","brain":"673.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"372.3","Brain inhibitory neurons":"114.2","Early primary spermatocytes":"128.7","Early spermatids":"67.1","Late primary spermatocytes":"456.2","Leydig cells":"922.0","Peritubular myoid cells":"213.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"372.3","Leydig cells":"922.0","Spermatogenic cell types":"456.2","Stromal cells":"213.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"116.6","medium spiny neuron":"341.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Squamous Cell Carcinoma (TCGA)":"34.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Rhabdoid":"795.3"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB016390":null,"HPA013138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"}},{"Gene":"PEX10","Gene synonym":["RNF69"],"Ensembl":"ENSG00000157911","Gene description":"Peroxisomal biogenesis factor 10","Uniprot":["O60683"],"Chromosome":"1","Position":"2403964-2413797","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Peroxisome biogenesis","Protein transport","Transport","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Peroxisome biogenesis disorder","Zellweger syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"366.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"366.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049755":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.26e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.98e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"}},{"Gene":"PEX11A","Gene synonym":["MGC119947","MGC138534","PEX11alpha","PMP28"],"Ensembl":"ENSG00000166821","Gene description":"Peroxisomal biogenesis factor 11 alpha","Uniprot":["O75192"],"Chromosome":"15","Position":"89677764-89690783","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Peroxisome biogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"49.7","Hepatocytes":"47.9","Late spermatids":"60.2","Prostatic club cells":"57.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Skin - Sebaceous gland cells","Spleen - Fibroblasts_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3733","Protein cell type specific Intensity":{"Hepatocytes":"373328.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1465","Protein tissue specific Intensity":{"liver":"146490.6"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.82e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA069817":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":11,"Subcellular main location":["Peroxisomes"],"Subcellular additional location":null,"Antibody RRID":{"CAB032689":null,"HPA032141":null,"HPA032142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.09e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"}},{"Gene":"PEX16","Gene synonym":[],"Ensembl":"ENSG00000121680","Gene description":"Peroxisomal biogenesis factor 16","Uniprot":["Q9Y5Y5"],"Chromosome":"11","Position":"45909663-45918812","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Peroxisome biogenesis"],"Molecular function":null,"Disease involvement":["Disease variant","Peroxisome biogenesis disorder","Zellweger syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"93.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 6: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":28,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043286":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.60e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"}},{"Gene":"PEX3","Gene synonym":[],"Ensembl":"ENSG00000034693","Gene description":"Peroxisomal biogenesis factor 3","Uniprot":["P56589"],"Chromosome":"6","Position":"143450805-143490616","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Peroxisome biogenesis"],"Molecular function":null,"Disease involvement":["Disease variant","Peroxisome biogenesis disorder","Zellweger syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"113.3","Pituitary stem cells":"121.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":36,"Subcellular main location":["Nucleoplasm","Peroxisomes"],"Subcellular additional location":null,"Antibody RRID":{"HPA042830":null,"HPA058006":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.90e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA058026":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PFDN4","Gene synonym":["C-1","C1","PFD4"],"Ensembl":"ENSG00000101132","Gene description":"Prefoldin subunit 4","Uniprot":["Q9NQP4"],"Chromosome":"20","Position":"54208087-54228052","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"355.0","Late primary spermatocytes":"409.5","Oocytes":"331.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"331.6","Proliferating cells":"355.0","Spermatogenic cell types":"409.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"430000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":45,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024055":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.30e-8"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"95000","Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":134,"Subcellular main location":["Intermediate filaments","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"}},{"Gene":"PFDN6","Gene synonym":["H2-KE2","HKE2","KE-2","PFD6"],"Ensembl":"ENSG00000204220","Gene description":"Prefoldin subunit 6","Uniprot":["O15212"],"Chromosome":"6","Position":"33289302-33298401","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"131.1","Late primary spermatocytes":"192.8","Oocytes":"244.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"244.1","Spermatogenic cell types":"192.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"85.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":81,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA043032":null,"HPA048123":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"PFKP","Gene synonym":["PFK-C","PFKF"],"Ensembl":"ENSG00000067057","Gene description":"Phosphofructokinase, platelet","Uniprot":["Q01813"],"Chromosome":"10","Position":"3066333-3137718","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Glycolysis"],"Molecular function":["Allosteric enzyme","Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"250.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"202.0","Late primary spermatocytes":"241.3","Late spermatids":"287.5","M\u00fcller glia":"186.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"287.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"159455868.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"280681474.6"},"Antibody":["HPA018257","HPA056484"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1400000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":45,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA018257":null,"HPA056484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.15e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"PFN4","Gene synonym":[],"Ensembl":"ENSG00000176732","Gene description":"Profilin family member 4","Uniprot":["Q8NHR9"],"Chromosome":"2","Position":"24114809-24123464","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"25","RNA tissue specific nTPM":{"testis":"77.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"476.9","Late primary spermatocytes":"1354.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"127","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1354.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.58e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.87e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"PGAM5","Gene synonym":["BXLBv68","MGC5352"],"Ensembl":"ENSG00000247077","Gene description":"PGAM family member 5, mitochondrial serine\/threonine protein phosphatase","Uniprot":["Q96HS1"],"Chromosome":"12","Position":"132710819-132722734","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Necrosis"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"29.6","Late spermatids":"32.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036978","HPA036979","CAB068215"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9100","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB068215":null,"HPA036978":null,"HPA036979":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.88e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.84e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"PGAP2","Gene synonym":["CWH43-N","FRAG1","MRT17","MRT21"],"Ensembl":"ENSG00000148985","Gene description":"Post-GPI attachment to proteins 2","Uniprot":["Q9UHJ9"],"Chromosome":"11","Position":"3797724-3826371","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["GPI-anchor biosynthesis"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"epididymis":"204.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"107.7","Early spermatids":"182.1","Epididymal principal cells":"289.8","Late spermatids":"514.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"289.8","Spermatogenic cell types":"514.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Kidney - Fibroblasts","Liver - Hepatocytes","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"347211.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"983","Protein tissue specific Intensity":{"intestine":"98259.4"},"Antibody":["HPA063099"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":4,"Subcellular main location":["Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA063099":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.14e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.36e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.93e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"}},{"Gene":"PGBD4","Gene synonym":["FLJ32638","FLJ37497"],"Ensembl":"ENSG00000182405","Gene description":"PiggyBac transposable element derived 4","Uniprot":["Q96DM1"],"Chromosome":"15","Position":"34102083-34108686","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"4.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"14.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"3.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"3.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA040896":null,"HPA059823":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.44e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"}},{"Gene":"PGK2","Gene synonym":["PGK-2","PGKPS"],"Ensembl":"ENSG00000170950","Gene description":"Phosphoglycerate kinase 2","Uniprot":["P07205"],"Chromosome":"6","Position":"49785660-49787285","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Glycolysis"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"526","RNA tissue specific nTPM":{"testis":"186.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"4751.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"413","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4751.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"1528291.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045385","HPA073644","HPA073656"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":13,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA045385":null,"HPA073644":null,"HPA073656":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PGLYRP3","Gene synonym":["PGLYRPIalpha","PGRP-Ialpha","PGRPIA"],"Ensembl":"ENSG00000159527","Gene description":"Peptidoglycan recognition protein 3","Uniprot":["Q96LB9"],"Chromosome":"1","Position":"153297116-153312952","Protein class":["Metabolic proteins","Predicted secreted proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":["Antibiotic","Antimicrobial"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"esophagus":"27.2","skin 1":"49.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Esophageal apical cells":"227.2","Esophageal suprabasal cells":"73.4","Suprabasal keratinocytes":"60.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"227.2","Suprabasal cells":"73.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"12.5","Head and Neck Squamous Cell Carcinoma (TCGA)":"23.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"basophil":"8.4","eosinophil":"3.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"55","RNA blood lineage specific nTPM":{"granulocytes":"8.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"4.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030369"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Immunity","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030369":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PGP","Gene synonym":[],"Ensembl":"ENSG00000184207","Gene description":"Phosphoglycolate phosphatase","Uniprot":["A6NDG6"],"Chromosome":"16","Position":"2211593-2214840","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"59.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"2429.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2429.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"23659919.4"},"Antibody":["HPA043096","HPA046739"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"260000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":3,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA043096":null,"HPA046739":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.54e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.99e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"}},{"Gene":"PHC2","Gene synonym":["EDR2","HPH2"],"Ensembl":"ENSG00000134686","Gene description":"Polyhomeotic homolog 2","Uniprot":["Q8IXK0"],"Chromosome":"1","Position":"33323623-33431095","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"314.5","Neutrophils":"897.2","Retinal horizontal cells":"300.5","Rod photoreceptor cells":"299.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"897.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"neutrophil":"93.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"granulocytes":"93.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Skin - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"3883139.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"717652.9","Stomach":"825573.8"},"Antibody":["HPA047403"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":89,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047403":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.57e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.78e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.85e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.57e-7"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"}},{"Gene":"PHF1","Gene synonym":["MTF2L2","PCL1","TDRD19C"],"Ensembl":"ENSG00000112511","Gene description":"PHD finger protein 1","Uniprot":["O43189"],"Chromosome":"6","Position":"33410399-33416453","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"30.2","Bergmann glia":"31.7","Brain inhibitory neurons":"29.6","Late spermatids":"115.0","Oligodendrocyte progenitor cells":"31.1","Other brain neurons":"34.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"34.2","Spermatogenic cell types":"115.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"3274726.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"1737531.7","pancreas":"1582092.4","salivary gland":"3073417.9"},"Antibody":["HPA031038","HPA076579"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":76,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA031038":null,"HPA076579":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.63e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"}},{"Gene":"PHF20","Gene synonym":["C20orf104","dJ1121G12.1","TDRD20A"],"Ensembl":"ENSG00000025293","Gene description":"PHD finger protein 20","Uniprot":["Q9BVI0"],"Chromosome":"20","Position":"35771974-35950370","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"1081.5","Mast cells":"1108.7","Neutrophils":"1233.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mast cells":"1108.7","Neutrophils":"1233.7","Spermatogenic cell types":"1081.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":38,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear membrane","Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA029619":null,"HPA029620":null,"HPA029621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.60e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"}},{"Gene":"PHF7","Gene synonym":["HSPC226","NYD-SP6"],"Ensembl":"ENSG00000010318","Gene description":"PHD finger protein 7","Uniprot":["Q9BWX1"],"Chromosome":"3","Position":"52410660-52423641","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"213","RNA tissue specific nTPM":{"testis":"1149.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"680.6","Early spermatids":"2532.2","Late primary spermatocytes":"3496.6","Late spermatids":"12449.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"200","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"12449.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"12.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA036283":null,"HPA070305":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"}},{"Gene":"PHGDH","Gene synonym":["PDG","PGDH","SERA"],"Ensembl":"ENSG00000092621","Gene description":"Phosphoglycerate dehydrogenase","Uniprot":["O43175"],"Chromosome":"1","Position":"119648411-119744218","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Amino-acid biosynthesis","Serine biosynthesis"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"182.6","Epididymal principal cells":"269.4","Esophageal basal cells":"209.4","Lacrimal acinar cells":"199.3","Late spermatids":"198.0","Salivary acinar cells":"140.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"269.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"54.4","Bergmann glia":"61.5","oligodendrocyte":"56.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD8 T-cell":"25.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB003681","HPA021241","HPA024031","CAB068216"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Mitotic spindle","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"490000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":57,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":["Mitotic spindle","Primary cilium"],"Antibody RRID":{"CAB003681":null,"CAB068216":null,"HPA021241":null,"HPA024031":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"}},{"Gene":"PHKG2","Gene synonym":[],"Ensembl":"ENSG00000156873","Gene description":"Phosphorylase kinase catalytic subunit gamma 2","Uniprot":["P15735"],"Chromosome":"16","Position":"30748293-30761176","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Carbohydrate metabolism","Glycogen metabolism"],"Molecular function":["Calmodulin-binding","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Glycogen storage disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"123.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"2899.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2899.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"22737120.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"8973529.1"},"Antibody":["HPA065618","HPA068751"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":31,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA065618":null,"HPA068751":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"}},{"Gene":"PHLDB3","Gene synonym":["FLJ40193"],"Ensembl":"ENSG00000176531","Gene description":"Pleckstrin homology like domain family B member 3","Uniprot":["Q6NSJ2"],"Chromosome":"19","Position":"43474954-43504935","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"43.0","skin 1":"44.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"596.2","Esophageal suprabasal cells":"151.2","Ocular epithelial cells":"98.7","Suprabasal keratinocytes":"114.3","Syncytiotrophoblasts":"116.4","Urothelial cells":"99.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"596.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"87.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland basal cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"2524254.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043425"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":6,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA043425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.36e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.60e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"}},{"Gene":"PHOSPHO2","Gene synonym":["MGC22679"],"Ensembl":"ENSG00000144362","Gene description":"Phosphatase, orphan 2","Uniprot":["Q8TCD6"],"Chromosome":"2","Position":"169694454-169701708","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"51.4","Late primary spermatocytes":"37.2","Late spermatids":"9.5","Tuft cells":"11.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"51.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"14830","Protein cell type specific Intensity":{"Granulosa cells":"1482978.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034726","HPA034727"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":7,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA034726":null,"HPA034727":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.61e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.29e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"PHTF1","Gene synonym":["PHTF"],"Ensembl":"ENSG00000116793","Gene description":"Putative homeodomain transcription factor 1","Uniprot":["Q9UMS5"],"Chromosome":"1","Position":"113696831-113759489","Protein class":["Plasma proteins","Predicted membrane proteins","Transcription factors"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"257.4","Megakaryocyte-Erythroid progenitors":"661.9","Neutrophils":"485.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"661.9","Neutrophils":"485.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059486"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":1,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA059486":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"}},{"Gene":"PHYHIPL","Gene synonym":["Em:AC025038.1","KIAA1796"],"Ensembl":"ENSG00000165443","Gene description":"Phytanoyl-CoA 2-hydroxylase interacting protein like","Uniprot":["Q96FC7"],"Chromosome":"10","Position":"59176643-59247774","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"17.4","brain":"51.4","retina":"28.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"377.2","Bergmann glia":"804.8","Ependymal cells":"318.6","Late primary spermatocytes":"301.5","Late spermatids":"420.6","M\u00fcller glia":"404.8","Oligodendrocyte progenitor cells":"498.2","Oligodendrocytes":"538.2","Pituicytes\/FSCs":"354.3","Retinal bipolar cells":"308.8","Retinal ganglion cells":"332.2","Retinal horizontal cells":"306.5","Retinal pigment epithelial cells":"311.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"318.6","Glial cells":"804.8","Neuronal cells":"332.2","Pigment cells":"311.2","Spermatogenic cell types":"420.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"1081.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"19.5","Kidney Renal Clear Cell Carcinoma (TCGA)":"7.5","Kidney Renal Papillary Cell Carcinoma (TCGA)":"19.3","Prostate Adenocarcinoma (TCGA)":"9.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"21.1"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Smooth muscle cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"48435383.2","Microglia and Neuropil":"61407314.3","Neurons":"58828653.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"87361666.1"},"Antibody":["HPA038746"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038746":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"}},{"Gene":"PIAS1","Gene synonym":["DDXBP1","GBP","GU\/RH-II","ZMIZ3"],"Ensembl":"ENSG00000033800","Gene description":"Protein inhibitor of activated STAT 1","Uniprot":["O75925"],"Chromosome":"15","Position":"68054309-68198603","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["DNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"1313.0","Neutrophils":"1663.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1663.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Macrophages","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"1979331.3","Neutrophils":"1070687.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"321","Protein tissue specific Intensity":{"lymphoid tissue":"32053.9"},"Antibody":["CAB012304","HPA073610"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":116,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB012304":null,"HPA073610":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.11e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":55,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA068792":null,"HPA077584":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.48e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"}},{"Gene":"PIAS4","Gene synonym":["FLJ12419","Piasg","PIASY","ZMIZ6"],"Ensembl":"ENSG00000105229","Gene description":"Protein inhibitor of activated STAT 4","Uniprot":["Q8N2W9"],"Chromosome":"19","Position":"4007736-4039386","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway","Wnt signaling pathway"],"Molecular function":["DNA-binding","Repressor","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"86.0","Late primary spermatocytes":"147.2","Late spermatids":"409.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"409.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"826188.7","Distal tubules":"389542.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"94","Protein tissue specific Intensity":{"intestine":"9395.7"},"Antibody":["HPA010598","HPA076008"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":83,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA010598":null,"HPA076008":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - 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Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"8357019.2","Keratinocytes":"7375709.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"12902850.9"},"Antibody":["HPA052269","HPA066120"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centriolar satellite","Centrosome","Basal body"],"Secretome location":"Secreted to blood","Secretome function":"Immunity","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":26,"Subcellular main location":["Centriolar satellite","Centrosome"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA052269":null,"HPA066120":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"}},{"Gene":"PIERCE1","Gene synonym":["C9orf116","MGC29761","RbEST47"],"Ensembl":"ENSG00000160345","Gene description":"Piercer of microtubule wall 1","Uniprot":["Q5BN46"],"Chromosome":"9","Position":"135495181-135501734","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"57.7","fallopian tube":"91.4","testis":"59.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"430.3","Endometrial ciliated cells":"451.3","Epididymal efferent duct ciliated cells":"810.5","Fallopian tube ciliated cells":"827.9","Late primary spermatocytes":"533.3","Late spermatids":"685.5","Respiratory ciliated cells":"792.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Ciliated cells":"827.9","Spermatogenic cell types":"685.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"73.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm","Mid piece"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA021439":null,"HPA065287":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.94e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.21e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"}},{"Gene":"PIERCE2","Gene synonym":["C15orf65","FLJ27352"],"Ensembl":"ENSG00000261652","Gene description":"Piercer of microtubule wall 2","Uniprot":["H3BRN8"],"Chromosome":"15","Position":"55408495-55418798","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"167.8","Endometrial ciliated cells":"91.2","Epididymal efferent duct ciliated cells":"83.1","Fallopian tube ciliated cells":"83.2","Late primary spermatocytes":"171.9","Respiratory ciliated cells":"98.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"98.1","Spermatogenic cell types":"171.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"50.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"4.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"4.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"17265","Protein cell type specific Intensity":{"Fallopian tube cells":"1726458.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"22500","Protein tissue specific Intensity":{"fallopian tube":"2249978.5"},"Antibody":["HPA067189"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA067189":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.63e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"}},{"Gene":"PIEZO2","Gene synonym":["C18orf30","C18orf58","FAM38B","FAM38B2","FLJ23144","FLJ23403","FLJ34907","HsT748","HsT771"],"Ensembl":"ENSG00000154864","Gene description":"Piezo type mechanosensitive ion channel component 2","Uniprot":["Q9H5I5"],"Chromosome":"18","Position":"10666483-11149569","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Sensory transduction","Transport"],"Molecular function":["Ion channel"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Fibro-adipogenic progenitors":"70.2","Gonadotrophs":"161.3","Lymphatic endothelial cells":"343.5","Megakaryocyte progenitors":"220.0","Mesothelial cells":"156.9","Oligodendrocytes":"400.4","Pancreatic acinar cells":"72.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"156.9","Endothelial cells":"343.5","Glial cells":"400.4","Megakaryocytes":"220.0","Pituitary endocrine cells":"161.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"586.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"22.3","liver cancer":"17.2"},"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015986","HPA031974","HPA040616"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA015986":null,"HPA031974":null,"HPA040616":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.23e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.15e-5"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PIFO","Gene synonym":["C1orf88","FLJ23853","pitchfork"],"Ensembl":"ENSG00000173947","Gene description":"Primary cilia formation","Uniprot":["Q8TCI5"],"Chromosome":"1","Position":"111346600-111353013","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"134.0","fallopian tube":"163.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"494.8","Endometrial ciliated cells":"542.0","Epididymal efferent duct ciliated cells":"681.6","Fallopian tube ciliated cells":"1264.9","Late primary spermatocytes":"270.5","Late spermatids":"642.0","Respiratory ciliated cells":"949.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"25","RNA single cell type group specific nCPM":{"Ciliated cells":"1264.9","Spermatogenic cell types":"642.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"12","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"76.6","ependymal cell":"179.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"65.6"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Bile duct cancer":"8.4","testis cancer":"7.3"},"RNA tissue cell type enrichment":["Breast - Breast myoepithelial cells","Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2212","Protein cell type specific Intensity":{"Fallopian tube cells":"221166.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA079487"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA079487":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.75e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.33e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"}},{"Gene":"PIGB","Gene synonym":[],"Ensembl":"ENSG00000069943","Gene description":"Phosphatidylinositol glycan anchor biosynthesis class B","Uniprot":["Q92521"],"Chromosome":"15","Position":"55318960-55355648","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["GPI-anchor biosynthesis"],"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"131.7","Neutrophil progenitors":"89.2","Neutrophils":"112.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"131.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"84487.9","Fallopian tube cells":"115808.6","Pancreas epithelial cells":"32363.3","Pancreatic islets":"112108.1","Proximal tubules":"70956.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039929"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039929":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"}},{"Gene":"PIGF","Gene synonym":[],"Ensembl":"ENSG00000151665","Gene description":"Phosphatidylinositol glycan anchor biosynthesis class F","Uniprot":["Q07326"],"Chromosome":"2","Position":"46580937-46617055","Protein class":["Disease related genes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["GPI-anchor biosynthesis"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"290.4","Epicardial cells":"247.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"247.9","Myocytes":"290.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051389":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.08e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.44e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"}},{"Gene":"PIGN","Gene synonym":["MCD4","PIG-N"],"Ensembl":"ENSG00000197563","Gene description":"Phosphatidylinositol glycan anchor biosynthesis class N","Uniprot":["O95427"],"Chromosome":"18","Position":"61905255-62187118","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["GPI-anchor biosynthesis"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Parietal cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"2278244.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1479146.5","lymphoid tissue":"4432708.2","pancreas":"5279698.0","salivary gland":"2423754.3"},"Antibody":["HPA039922","HPA040374"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":14,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039922":null,"HPA040374":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.07e-7"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA041706":null,"HPA046766":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.71e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.51e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"}},{"Gene":"PIGV","Gene synonym":["FLJ20477"],"Ensembl":"ENSG00000060642","Gene description":"Phosphatidylinositol glycan anchor biosynthesis class V","Uniprot":["Q9NUD9"],"Chromosome":"1","Position":"26787054-26800659","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["GPI-anchor biosynthesis"],"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"47.6","Late primary spermatocytes":"126.7","Late spermatids":"169.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"169.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"14925.7","Hepatocytes":"23767.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054181"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA054181":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.36e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.55e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.59e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"}},{"Gene":"PIH1D2","Gene synonym":["DNAAF15"],"Ensembl":"ENSG00000150773","Gene description":"PIH1 domain containing 2","Uniprot":["Q8WWB5"],"Chromosome":"11","Position":"112063218-112074274","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"62.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"67.0","Early spermatids":"371.4","Endometrial ciliated cells":"97.7","Ependymal cells":"102.3","Epididymal efferent duct ciliated cells":"85.2","Fallopian tube ciliated cells":"153.6","Late primary spermatocytes":"674.0","Late spermatids":"179.4","Respiratory ciliated cells":"176.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Ciliated cells":"176.7","Spermatogenic cell types":"674.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"42.2","ependymal cell":"116.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"6211","Protein cell type specific Intensity":{"Fallopian tube cells":"621112.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"467","Protein tissue specific Intensity":{"fallopian tube":"46715.3"},"Antibody":["HPA039496"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":64,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Basal body","Cytosol"],"Antibody RRID":{"HPA039496":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-3"}},{"Gene":"PIK3CG","Gene synonym":[],"Ensembl":"ENSG00000105851","Gene description":"Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma","Uniprot":["P48736"],"Chromosome":"7","Position":"106865278-106908980","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Angiogenesis","Chemotaxis","Endocytosis","Immunity","Inflammatory response","Lipid metabolism"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"41.2","lymphoid tissue":"18.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"66.2","Microglia":"72.4","Monocyte progenitors":"82.7","monocytes":"64.6","Neutrophil progenitors":"331.3","Neutrophils":"326.7","NK-cells":"66.8","pDCs":"112.3","Plasma cells":"146.5","Tuft cells":"564.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"331.3","Plasma cells":"146.5","Secretory gland support":"564.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"20","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"97.0","leukocyte":"90.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"14","RNA cell line specific nTPM":{"Leukemia":"18.8","lymphoma":"26.1","Myeloma":"22.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":10,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA069976":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.44e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"}},{"Gene":"PIK3R3","Gene synonym":["p55"],"Ensembl":"ENSG00000117461","Gene description":"Phosphoinositide-3-kinase regulatory subunit 3","Uniprot":["Q92569"],"Chromosome":"1","Position":"46040140-46133036","Protein class":["Cancer-related genes","Metabolic proteins","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"71.8","Differentiating spermatogonia":"26.0","Early primary spermatocytes":"27.3","Kupffer cells":"28.7","Late spermatids":"26.9","Respiratory deuterosomal cells":"28.0","Respiratory secretory cells":"29.7","Salivary duct cells":"44.7","Undifferentiated spermatogonia":"26.6","Vascular endothelial cells":"69.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"44.7","Endothelial cells":"69.3","Goblet cells":"71.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"32.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"5.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"5.8","monocytes":"2.4","T-cells":"2.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Adipocytes (Breast)","Colon - Endothelial cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"88937.5","Oocytes":"34347.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"352","Protein tissue specific Intensity":{"bone marrow":"35156.8"},"Antibody":["HPA005751"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol","Connecting piece","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":144,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Connecting piece","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA005751":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.78e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.04e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"}},{"Gene":"PIK3R6","Gene synonym":["C17orf38","FLJ34500","HsT41028","p87PIKAP"],"Ensembl":"ENSG00000276231","Gene description":"Phosphoinositide-3-kinase regulatory subunit 6","Uniprot":["Q5UE93"],"Chromosome":"17","Position":"8802722-8867677","Protein class":["Predicted intracellular proteins"],"Biological process":["Angiogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"4.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"21.5","Early spermatids":"20.9","Hematopoietic stem cells":"18.9","Hofbauer cells":"24.7","Late spermatids":"37.0","Macrophages":"24.4","Mast cells":"112.9","Megakaryocyte progenitors":"22.9","Microglia":"45.0","monocytes":"22.3","Neutrophil progenitors":"20.9","Neutrophils":"40.7","Thymocytes":"27.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"45.0","Mast cells":"112.9","Neutrophils":"40.7","Spermatogenic cell types":"37.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"51.3","pericyte":"66.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"22.0","eosinophil":"75.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"75.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"7.3","lymphoma":"5.9"},"RNA tissue cell type enrichment":["Adrenal gland - Macrophages","Colon - Mast cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"6868","Protein cell type specific Intensity":{"Macrophages":"792760.3","Neutrophils":"546372.5","T-cells":"721306.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"541571.1","lymphoid tissue":"230899.9"},"Antibody":["HPA023077"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":3,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA023077":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.60e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PIN1","Gene synonym":["dod"],"Ensembl":"ENSG00000127445","Gene description":"Peptidylprolyl cis\/trans isomerase, NIMA-interacting 1","Uniprot":["Q13526"],"Chromosome":"19","Position":"9835257-9849689","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Isomerase","Rotamase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"256.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"277.3","Late primary spermatocytes":"338.6","Late spermatids":"1255.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1255.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"83000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":193,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB004528":null,"CAB009326":null,"HPA068650":null,"HPA070887":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.12e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"}},{"Gene":"PINK1","Gene synonym":["BRPK","PARK6"],"Ensembl":"ENSG00000158828","Gene description":"PTEN induced kinase 1","Uniprot":["Q9BXM7"],"Chromosome":"1","Position":"20633458-20651511","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Autophagy"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Neurodegeneration","Parkinson disease","Parkinsonism","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"358.8","tongue":"366.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"207.9","Late primary spermatocytes":"179.0","Late spermatids":"244.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"207.9","Spermatogenic cell types":"244.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"8.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001931","CAB026191"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":195,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB026191":null,"HPA001931":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.98e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.55e-15"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.90e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.59e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"}},{"Gene":"PINX1","Gene synonym":["FLJ20565","Gno1","LPTL","LPTS","MGC8850","Pxr1"],"Ensembl":"ENSG00000254093","Gene description":"PIN2 (TERF1) interacting telomerase inhibitor 1","Uniprot":["Q96BK5"],"Chromosome":"8","Position":"10764961-10839884","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"22.1","Late primary spermatocytes":"19.8","Late spermatids":"28.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"28.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"224608.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023139","HPA023146"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":43,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Mitochondria"],"Antibody RRID":{"HPA023139":null,"HPA023146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"PIP4K2C","Gene synonym":["FLJ22055","PIP5K2C"],"Ensembl":"ENSG00000166908","Gene description":"Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma","Uniprot":["Q8TBX8"],"Chromosome":"12","Position":"57591174-57603418","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"72.9","Foveolar cells":"94.9","Late spermatids":"72.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"94.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 68: Foveolar cells - Mucosal defense","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA028658":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"}},{"Gene":"PIP5K1C","Gene synonym":["KIAA0589","LCCS3","PIP5Kgamma"],"Ensembl":"ENSG00000186111","Gene description":"Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma","Uniprot":["O60331"],"Chromosome":"19","Position":"3630183-3700468","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell adhesion","Chemotaxis","Endocytosis","Exocytosis","Lipid metabolism","Phagocytosis"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"116.0"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Lung - Smooth muscle cells","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"23371522.6","Cardiomyocytes":"6113502.8","Microglia and Neuropil":"23947018.1","Neurons":"11209633.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"34089467.2","intestine":"11157896.6"},"Antibody":["HPA017168"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA017168":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.65e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"}},{"Gene":"PITPNM3","Gene synonym":["ACKR6","CORD5","NIR1","RDGBA3"],"Ensembl":"ENSG00000091622","Gene description":"PITPNM family member 3","Uniprot":["Q9BZ71"],"Chromosome":"17","Position":"6451263-6556555","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cone-rod dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"37.5","lymphoid tissue":"57.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"51.5","Esophageal apical cells":"44.8","Esophageal suprabasal cells":"48.4","Respiratory basal cells":"49.8","Respiratory deuterosomal cells":"50.8","Respiratory secretory cells":"54.1","Transitional alveolar cells":"44.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"23","RNA blood cell specific nTPM":{"neutrophil":"2.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"23","RNA blood lineage specific nTPM":{"granulocytes":"2.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":4,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA022432":null,"HPA059005":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.94e-6"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"}},{"Gene":"PIWIL1","Gene synonym":["CT80.1","HIWI","PIWI"],"Ensembl":"ENSG00000125207","Gene description":"Piwi like RNA-mediated gene silencing 1","Uniprot":["Q96J94"],"Chromosome":"12","Position":"130337887-130372637","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","RNA-mediated gene silencing","Spermatogenesis","Translation regulation"],"Molecular function":["Developmental protein","Endonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"36","RNA tissue specific nTPM":{"testis":"39.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"8.3","Early primary spermatocytes":"10.2","Early spermatids":"30.1","Late primary spermatocytes":"71.6","Late spermatids":"23.4","Rod photoreceptor cells":"16.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"71.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"4.5","deep-layer near-projecting":"14.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"colorectal cancer":"3.0","Gastric cancer":"2.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA066880":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PJVK","Gene synonym":["DFNB59"],"Ensembl":"ENSG00000204311","Gene description":"Pejvakin","Uniprot":["Q0ZLH3"],"Chromosome":"2","Position":"178451346-178462102","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Hearing"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"37.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"224.4","Late primary spermatocytes":"237.6","Late spermatids":"140.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"237.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"plasmacytoid DC":"2.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"2.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.80e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"}},{"Gene":"PKD2L1","Gene synonym":["PCL","PKD2L","PKDL","TRPP3"],"Ensembl":"ENSG00000107593","Gene description":"Polycystin 2 like 1, transient receptor potential cation channel","Uniprot":["Q9P0L9"],"Chromosome":"10","Position":"100288149-100330264","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calcium channel","Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"7.6","retina":"12.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"24.3","Hofbauer cells":"16.0","Kupffer cells":"30.7","Late spermatids":"34.8","Podocytes":"16.5","Respiratory ionocytes":"10.2","Retinal horizontal cells":"86.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"30.7","Neuronal cells":"86.1","Renal nephron cells":"16.5","Spermatogenic cell types":"34.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer intratelencephalic":"7.7","deep-layer near-projecting":"19.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"5.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"2.2","Uterine cancer":"1.0"},"RNA tissue cell type enrichment":["Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"513899.5","Neutrophils":"639554.1","T-cells":"755209.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB022621","HPA070002"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Actin filaments","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Actin filaments","Cytosol"],"Antibody RRID":{"CAB022621":null,"HPA070002":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PKD2L2","Gene synonym":["TRPP5"],"Ensembl":"ENSG00000078795","Gene description":"Polycystin 2 like 2, transient receptor potential cation channel","Uniprot":["Q9NZM6"],"Chromosome":"5","Position":"137887968-137942747","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"7.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"619.7","Epicardial cells":"156.9","Late primary spermatocytes":"185.0","Myonuclei":"88.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"156.9","Myocytes":"619.7","Spermatogenic cell types":"185.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"5.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041903","HPA043634"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA041903":null,"HPA043634":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"}},{"Gene":"PKDREJ","Gene synonym":[],"Ensembl":"ENSG00000130943","Gene description":"Polycystin family receptor for egg jelly","Uniprot":["Q9NTG1"],"Chromosome":"22","Position":"46255663-46263343","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"3.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"4.4","Cone photoreceptor cells":"2.1","Early primary spermatocytes":"4.3","Early spermatids":"2.2","Late primary spermatocytes":"12.8","Late spermatids":"1.5","Retinal horizontal cells":"2.0","Retinal pigment epithelial cells":"4.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"4.4","Pigment cells":"4.3","Spermatogenic cell types":"12.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PKHD1","Gene synonym":["ARPKD","FCYT","FPC","TIGM1"],"Ensembl":"ENSG00000170927","Gene description":"PKHD1 ciliary IPT domain containing fibrocystin\/polyductin","Uniprot":["P08F94"],"Chromosome":"6","Position":"51615299-52087613","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"epididymis":"4.5","kidney":"12.7","pancreas":"8.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"991.3","Distal convoluted tubule cells":"3139.1","Loop of henle epithelial cells":"2248.0","Pancreatic duct cells":"963.9","Papillary tip epithelial cells":"1061.1","Proximal tubule cells":"3459.8","Renal collecting duct intercalated cells":"633.6","Renal collecting duct principal cells":"2022.9","Renal connecting tubule cells":"2968.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ductal cells":"2968.5","Renal nephron cells":"3459.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"thalamic excitatory":"8.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"5.9","Kidney Renal Papillary Cell Carcinoma (TCGA)":"12.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.1","Kidney cancer":"2.0"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":1,"Subcellular main location":["Primary cilium","Cytosol"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA031227":null,"HPA031229":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PKIG","Gene synonym":[],"Ensembl":"ENSG00000168734","Gene description":"CAMP-dependent protein kinase inhibitor gamma","Uniprot":["Q9Y2B9"],"Chromosome":"20","Position":"44531785-44624247","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protein kinase inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"366.9","Megakaryocyte-Erythroid progenitors":"400.4","Smooth muscle cells":"334.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"400.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"memory B-cell":"371.9","naive B-cell":"378.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"B-cells":"378.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":6,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"HPA042703":null,"HPA063690":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.07e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.21e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA068860"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":48,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA068860":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.32e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.09e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.35e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.71e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.36e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"}},{"Gene":"PKNOX1","Gene synonym":["PREP1"],"Ensembl":"ENSG00000160199","Gene description":"PBX\/knotted 1 homeobox 1","Uniprot":["P55347"],"Chromosome":"21","Position":"42974510-43033931","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"191.7","Neutrophils":"191.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"191.5","Spermatogenic cell types":"191.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"199508.7","Granulosa cells":"763448.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"120751.1","salivary gland":"82149.3"},"Antibody":["CAB004285","HPA057215","HPA065017"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":26,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB004285":null,"HPA057215":null,"HPA065017":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.87e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"}},{"Gene":"PLA2G12B","Gene synonym":["PLA2G13"],"Ensembl":"ENSG00000138308","Gene description":"Phospholipase A2 group XIIB","Uniprot":["Q9BX93"],"Chromosome":"10","Position":"72934762-72954806","Protein class":["Plasma proteins","Predicted secreted proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"31.1","kidney":"13.4","liver":"66.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Enterocytes":"121.2","Hepatocytes":"74.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Enterocytes":"121.2","Hepatocytes":"74.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"1.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"33.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"liver cancer":"7.1"},"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3057","Protein cell type specific Intensity":{"Hepatocytes":"305678.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"24875","Protein tissue specific Intensity":{"liver":"2487537.8"},"Antibody":["HPA057745","HPA059562"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"220000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":null,"Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057745":null,"HPA059562":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLA2G4E","Gene synonym":["FLJ45651"],"Ensembl":"ENSG00000188089","Gene description":"Phospholipase A2 group IVE","Uniprot":["Q3MJ16"],"Chromosome":"15","Position":"41981394-42051190","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skin 1":"14.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"42.4","Cone photoreceptor cells":"20.7","Corticotrophs":"16.6","Early spermatids":"17.9","Esophageal apical cells":"56.4","Esophageal basal cells":"19.7","Esophageal suprabasal cells":"64.0","Late spermatids":"26.7","Suprabasal keratinocytes":"175.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"56.4","Basal cells":"42.4","Suprabasal cells":"175.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA1-3":"5.2","hippocampal CA4":"3.7","midbrain-derived inhibitory":"4.4"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"8.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Corticotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"35197","Protein cell type specific Intensity":{"Keratinocytes":"3519691.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"59","Protein tissue specific Intensity":{"intestine":"8051.2","salivary gland":"3651.2"},"Antibody":["HPA041105","HPA072562"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":null,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041105":null,"HPA072562":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLA2G6","Gene synonym":["iPLA2","iPLA2beta","NBIA2","PARK14","PNPLA9"],"Ensembl":"ENSG00000184381","Gene description":"Phospholipase A2 group VI","Uniprot":["O60733"],"Chromosome":"22","Position":"38111495-38214778","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","RAS pathway related proteins"],"Biological process":["Chemotaxis","Lipid metabolism","Phospholipid metabolism"],"Molecular function":["Calmodulin-binding","Hydrolase"],"Disease involvement":["Disease variant","Dystonia","Neurodegeneration","Parkinson disease","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"162.1","Enterocytes":"176.3","Epicardial cells":"627.7","Megakaryocyte-Erythroid progenitors":"250.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"627.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"3.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"27.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2097627.5","Keratinocytes":"1408274.7","Microglia and Neuropil":"2217743.4","Neurons":"1227884.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"19337","Protein tissue specific Intensity":{"cerebral cortex":"1933703.0"},"Antibody":["HPA000825","HPA001171"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Plasma membrane","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nuclear speckles","Microtubules"],"Antibody RRID":{"HPA000825":null,"HPA001171":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.40e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-7"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"}},{"Gene":"PLAAT1","Gene synonym":["A-C1","H-REV107","HRASLS","HRASLS1","PLA\/AT1","PLAAT-1"],"Ensembl":"ENSG00000127252","Gene description":"Phospholipase A and acyltransferase 1","Uniprot":["Q9HDD0"],"Chromosome":"3","Position":"193241128-193277738","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"skeletal muscle":"84.4","testis":"77.8","tongue":"41.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"140.8","Early spermatids":"534.6","Late primary spermatocytes":"688.7","Late spermatids":"174.4","Myonuclei":"78.9","Oligodendrocyte progenitor cells":"177.0","Platelets":"147.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"177.0","Neuronal cells":"140.8","Platelets":"147.6","Spermatogenic cell types":"688.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"229.6","oligodendrocyte precursor cell":"195.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"19.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":7,"Subcellular main location":["Focal adhesion sites"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA051179":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.81e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"}},{"Gene":"PLAAT5","Gene synonym":["HRASLS5","HRLP5","iNAT","PLAAT-5"],"Ensembl":"ENSG00000168004","Gene description":"Phospholipase A and acyltransferase 5","Uniprot":["Q96KN8"],"Chromosome":"11","Position":"63461404-63491194","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Acyltransferase","Hydrolase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"15.5","pancreas":"12.8","testis":"51.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"417.6","Late primary spermatocytes":"361.1","Late spermatids":"1549.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1549.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"3.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"65","RNA blood cell specific nTPM":{"basophil":"5.4","eosinophil":"16.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"97","RNA blood lineage specific nTPM":{"granulocytes":"16.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"ovarian cancer":"1.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Kidney - Proximal tubular cells","Minor Salivary Gland - Adipocytes (Minor salivary gland)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA079686"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA079686":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.29e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.06e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLAC8L1","Gene synonym":[],"Ensembl":"ENSG00000173261","Gene description":"PLAC8 like 1","Uniprot":["A1L4L8"],"Chromosome":"5","Position":"146084313-146105577","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"5.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"563.4","Late primary spermatocytes":"180.0","Late spermatids":"388.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"563.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA074266"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA074266":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLAGL2","Gene synonym":["ZNF900"],"Ensembl":"ENSG00000126003","Gene description":"PLAG1 like zinc finger 2","Uniprot":["Q9UPG8"],"Chromosome":"20","Position":"32192504-32207743","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"30.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"265.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"265.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"intermediate monocyte":"18.3","non-classical monocyte":"34.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"monocytes":"34.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005900","HPA077084"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":36,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA005900":null,"HPA077084":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.09e-6"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"}},{"Gene":"PLCD4","Gene synonym":[],"Ensembl":"ENSG00000115556","Gene description":"Phospholipase C delta 4","Uniprot":["Q9BRC7"],"Chromosome":"2","Position":"218607855-218637184","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Guanine-nucleotide releasing factor","Hydrolase","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"retina":"153.9","skeletal muscle":"106.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"296.0","Myonuclei":"370.6","Retinal bipolar cells":"300.4","Rod photoreceptor cells":"311.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Myocytes":"370.6","Neuronal cells":"311.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"9.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"3.8","Rhabdoid":"5.0"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"88391450.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"4099684.7"},"Antibody":["CAB009914","HPA038139","HPA038140"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Endoplasmic reticulum","Plasma membrane"],"Antibody RRID":{"CAB009914":null,"HPA038139":null,"HPA038140":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.74e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-4"}},{"Gene":"PLCH1","Gene synonym":["DKFZp434C1372","KIAA1069","MGC117152","PLCeta1","PLCL3"],"Ensembl":"ENSG00000114805","Gene description":"Phospholipase C eta 1","Uniprot":["Q4KWH8"],"Chromosome":"3","Position":"155375580-155745071","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase","Transducer"],"Disease involvement":["Disease variant","Holoprosencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"15.5","retina":"11.5","testis":"10.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"238.0","Bergmann glia":"449.3","Choroid plexus epithelial cells":"397.9","Early spermatids":"238.2","Endometrial ciliated cells":"347.4","Ependymal cells":"496.1","Fallopian tube ciliated cells":"257.8","Pituicytes\/FSCs":"439.3","Pituitary stem cells":"315.9","Respiratory ciliated cells":"495.4","Retinal amacrine cells":"419.3","Retinal horizontal cells":"234.4","Sertoli cells":"246.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"496.1","Glial cells":"449.3","Neuronal cells":"419.3","Stem cells":"315.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"665.2","ependymal cell":"538.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"9.6"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary gland ductal cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Skin - Eccrine sweat gland cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"3129622.6","Proximal tubules":"2475347.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"564791.4","pancreas":"1030964.0","salivary gland":"657162.4","Stomach":"2001071.4"},"Antibody":["HPA036176","HPA057978"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":18,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA036176":null,"HPA057978":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.89e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"}},{"Gene":"PLCL1","Gene synonym":["PLC-L","PLCE","PLCL","PPP1R127","PRIP"],"Ensembl":"ENSG00000115896","Gene description":"Phospholipase C like 1 (inactive)","Uniprot":["Q15111"],"Chromosome":"2","Position":"197804593-198572581","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"tongue":"38.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"1222.6","Choroid plexus epithelial cells":"1513.6","Decidual stromal cells":"843.4","Distal convoluted tubule cells":"2270.6","Endometrial stromal cells":"1975.1","Loop of henle epithelial cells":"1132.6","Neutrophils":"856.8","Oligodendrocytes":"2120.8","Pituicytes\/FSCs":"1900.6","Proximal tubule cells":"804.9","Renal collecting duct intercalated cells":"1873.5","Retinal pigment epithelial cells":"1295.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1513.6","Ductal cells":"1873.5","Glial cells":"2120.8","Renal nephron cells":"2270.6","Stromal cells":"1975.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"3101.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"8.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"1.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"T-cells":"1.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"2.3","Rhabdoid":"2.3"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Liver - Hepatic stellate cells","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"13033819.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"14612757.7"},"Antibody":["HPA031849"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA031849":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.54e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.95e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.72e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLCXD2","Gene synonym":["FLJ31579"],"Ensembl":"ENSG00000240891","Gene description":"Phosphatidylinositol specific phospholipase C X domain containing 2","Uniprot":["Q0VAA5"],"Chromosome":"3","Position":"111674676-111846447","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase","Transducer"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"13.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"60.0","Epididymal clear cells":"53.1","Hepatocytes":"160.0","Neuroendocrine cells":"39.8","NK-cells":"54.7","Parietal cells":"155.6","Retinal horizontal cells":"40.1","Rod photoreceptor cells":"54.0","T-cells":"42.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"155.6","Hepatocytes":"160.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"41.7","deep-layer near-projecting":"41.4","leukocyte":"53.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"3.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"3.8","NK-cells":"1.1","T-cells":"1.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA055947":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.37e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLCZ1","Gene synonym":["NYD-SP27","PLCzeta"],"Ensembl":"ENSG00000139151","Gene description":"Phospholipase C zeta 1","Uniprot":["Q86YW0"],"Chromosome":"12","Position":"18683169-18738100","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Fertilization","Lipid degradation","Lipid metabolism"],"Molecular function":["Developmental protein","Hydrolase","Transducer"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"testis":"39.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Early spermatids":"820.7","Late primary spermatocytes":"277.8","Late spermatids":"454.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"25","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"820.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"26.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"amygdala":"3.1"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2043","Protein cell type specific Intensity":{"Capillaries":"204335.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLEKHA1","Gene synonym":["TAPP1"],"Ensembl":"ENSG00000107679","Gene description":"Pleckstrin homology domain containing A1","Uniprot":["Q9HB21"],"Chromosome":"10","Position":"122374696-122432354","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"635.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"635.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"B-cells":"10.7","NK-cells":"22.0","T-cells":"28.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"11889112.5"},"Antibody":["HPA002043","HPA064795"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA002043":null,"HPA064795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.36e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.96e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"PLEKHA3","Gene synonym":["FAPP1"],"Ensembl":"ENSG00000116095","Gene description":"Pleckstrin homology domain containing A3","Uniprot":["Q9HB20"],"Chromosome":"2","Position":"178480457-178516463","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"196.0","Late spermatids":"739.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"739.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2764","Protein cell type specific Intensity":{"Oocytes":"276371.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"103076.0"},"Antibody":["HPA034496","HPA034497"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":14,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA034496":null,"HPA034497":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.90e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"}},{"Gene":"PLEKHA6","Gene synonym":["KIAA0969","PEPP3"],"Ensembl":"ENSG00000143850","Gene description":"Pleckstrin homology domain containing A6","Uniprot":["Q9Y2H5"],"Chromosome":"1","Position":"204218853-204377665","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"280.9","Proximal tubule cells":"565.1","Retinal amacrine cells":"272.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"565.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Fibroblasts","Breast - Breast glandular cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"32688029.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"15415102.9"},"Antibody":["HPA028152","HPA028157","HPA054311"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":3,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA028152":null,"HPA028157":null,"HPA054311":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.29e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.70e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"}},{"Gene":"PLEKHD1","Gene synonym":["UPF0639"],"Ensembl":"ENSG00000175985","Gene description":"Pleckstrin homology and coiled-coil domain containing D1","Uniprot":["A6NEE1"],"Chromosome":"14","Position":"69484692-69531551","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"9.5","parathyroid gland":"5.6","retina":"8.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Retinal horizontal cells":"364.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Neuronal cells":"364.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"113.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"7.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"15","RNA blood cell specific nTPM":{"plasmacytoid DC":"3.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"dendritic cells":"3.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"2.5"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Pituitary gland - Corticotropes","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebellum":"30.0"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"11647","Protein cell type specific Intensity":{"Distal tubules":"954538.8","Large ducts":"1374809.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051875"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051875":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":121,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024829":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.18e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.89e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"}},{"Gene":"PLEKHJ1","Gene synonym":["FLJ10297"],"Ensembl":"ENSG00000104886","Gene description":"Pleckstrin homology domain containing J1","Uniprot":["Q9NW61"],"Chromosome":"19","Position":"2230084-2237704","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"305.2","Enteric transient amplifying cells":"246.6","Enterocytes":"319.0","Paneth cells":"212.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"319.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 18: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":12,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA048989":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"PLEKHM2","Gene synonym":["KIAA0842"],"Ensembl":"ENSG00000116786","Gene description":"Pleckstrin homology and RUN domain containing M2","Uniprot":["Q8IWE5"],"Chromosome":"1","Position":"15684320-15734769","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"159.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"233.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA032304":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"}},{"Gene":"PLEKHO1","Gene synonym":["CKIP-1","OC120"],"Ensembl":"ENSG00000023902","Gene description":"Pleckstrin homology domain containing O1","Uniprot":["Q53GL0"],"Chromosome":"1","Position":"150149183-150164720","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"189.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"185.5","cDC":"226.4","Early spermatids":"256.2","Late primary spermatocytes":"292.1","Late spermatids":"525.8","Megakaryocytes":"197.8","Platelets":"1194.6","Smooth muscle cells":"349.4","Vascular smooth muscle cells":"167.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"1194.6","Smooth muscle cells":"349.4","Spermatogenic cell types":"525.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"169.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Vascular endothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"2603876.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"3846922.6"},"Antibody":["HPA061018"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":34,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA061018":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.27e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"}},{"Gene":"PLEKHS1","Gene synonym":["bA211N11.2","C10orf81","FLJ23537"],"Ensembl":"ENSG00000148735","Gene description":"Pleckstrin homology domain containing S1","Uniprot":["Q5SXH7"],"Chromosome":"10","Position":"113751262-113783429","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"breast":"23.2","cervix":"46.2","intestine":"34.6","pancreas":"25.6","salivary gland":"40.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"99.0","Lacrimal acinar cells":"109.6","Respiratory basal cells":"143.0","Respiratory ciliated cells":"268.1","Respiratory deuterosomal cells":"360.7","Respiratory secretory cells":"405.4","Salivary acinar cells":"103.6","Salivary duct cells":"143.8","Salivary ionocytes":"145.8","Submucosal glandular cells":"139.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"143.0","Ciliated cells":"360.7","Ductal cells":"143.8","Glandular cells":"139.3","Ionocytes":"145.8","Secretory cells":"405.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"14.3","breast cancer":"16.2"},"RNA tissue cell type enrichment":["Kidney - Macrophages","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Skin - Eccrine sweat gland cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1484","Protein cell type specific Intensity":{"Fallopian tube cells":"148357.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"53","Protein tissue specific Intensity":{"bone marrow":"3895.0","intestine":"7570.5","salivary gland":"4451.6"},"Antibody":["HPA037583"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":3,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA037583":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.03e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"}},{"Gene":"PLIN1","Gene synonym":["PLIN"],"Ensembl":"ENSG00000166819","Gene description":"Perilipin 1","Uniprot":["O60240"],"Chromosome":"15","Position":"89664367-89679427","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"adipose tissue":"898.1","breast":"459.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Adipocytes":"879.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Adipocytes":"879.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"11.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"20.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Minor Salivary Gland - Adipocytes (Minor salivary gland)","Skin - Adipocytes (Skin)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"6267394.2","Hepatocytes":"5864471.3","Neutrophils":"5679919.5","Smooth muscle cells":"6078765.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"99028564.3","intestine":"121234296.7","skin":"214017086.1"},"Antibody":["HPA024299","CAB033821","CAB037333"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Peroxisomes"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"29000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":5,"Subcellular main location":["Peroxisomes"],"Subcellular additional location":null,"Antibody RRID":{"CAB033821":null,"CAB037333":null,"HPA024299":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLK1","Gene synonym":["PLK"],"Ensembl":"ENSG00000166851","Gene description":"Polo like kinase 1","Uniprot":["P53350"],"Chromosome":"16","Position":"23677656-23690367","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Essential proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"30.2","lymphoid tissue":"40.9","testis":"31.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"36.7","Differentiating spermatogonia":"29.9","Early spermatids":"110.7","Enteric transient amplifying cells":"55.1","Erythrocyte progenitors":"39.7","Esophageal basal cells":"41.5","Extravillous trophoblasts":"58.9","Hofbauer cells":"32.1","Late primary spermatocytes":"180.3","Megakaryocyte progenitors":"36.9","Migrating cytotrophoblasts":"51.4","Monocyte progenitors":"108.1","Paneth cells":"30.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"108.1","Proliferating cells":"55.1","Spermatogenic cell types":"180.3","Trophoblast cells":"58.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"T-reg":"5.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"5.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":319,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051638":null,"HPA053229":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.16e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.72e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.99e-8"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.32e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.70e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.65e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.41e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.35e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"PLK2","Gene synonym":["SNK"],"Ensembl":"ENSG00000145632","Gene description":"Polo like kinase 2","Uniprot":["Q9NYY3"],"Chromosome":"5","Position":"58453982-58460139","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"247.1","Breast secretory cells":"163.6","Endometrial glandular cells":"159.4","Endometrial luminal cells":"165.9","Endometrial secretory cells":"205.2","Epididymal basal cells":"262.5","Extravillous trophoblasts":"389.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"262.5","Trophoblast cells":"389.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"NK-cell":"9.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"NK-cells":"9.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":7,"Subcellular main location":["Nucleoplasm","Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB009624":null,"HPA069329":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"}},{"Gene":"PLK4","Gene synonym":["Sak","STK18"],"Ensembl":"ENSG00000142731","Gene description":"Polo like kinase 4","Uniprot":["O00444"],"Chromosome":"4","Position":"127880893-127899224","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"21.3","lymphoid tissue":"13.4","testis":"21.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"28.7","Early spermatids":"63.2","Erythrocyte progenitors":"61.9","Late primary spermatocytes":"104.4","Late spermatids":"139.2","Megakaryocyte progenitors":"34.8","Monocyte progenitors":"47.4","Neutrophil progenitors":"32.2","Respiratory deuterosomal cells":"69.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"69.5","Erythrocytes":"61.9","Mononuclear phagocytes":"47.4","Spermatogenic cell types":"139.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1060","Protein tissue specific Intensity":{"cerebral cortex":"105977.5"},"Antibody":["HPA017327","HPA035026","HPA043198"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":42,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA017327":null,"HPA035026":null,"HPA043198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.39e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.07e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.31e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"}},{"Gene":"PLPPR1","Gene synonym":["FLJ20300","LPPR1","MGC26189","PRG-3"],"Ensembl":"ENSG00000148123","Gene description":"Phospholipid phosphatase related 1","Uniprot":["Q8TBJ4"],"Chromosome":"9","Position":"101028727-101325135","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"24.7","kidney":"14.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"78.6","Brain inhibitory neurons":"291.4","Distal convoluted tubule cells":"344.5","Loop of henle epithelial cells":"96.4","Oligodendrocyte progenitor cells":"804.1","Oligodendrocytes":"553.6","Other brain neurons":"73.6","Proximal tubule cells":"157.9","Renal collecting duct intercalated cells":"101.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"804.1","Neuronal cells":"291.4","Renal nephron cells":"344.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"1085.9","oligodendrocyte precursor cell":"885.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"16.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"1.1"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Pancreas - Alpha cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"24790.2","Proximal tubules":"70092.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"924","Protein tissue specific Intensity":{"cerebral cortex":"92425.8"},"Antibody":["HPA014760","HPA014968","HPA014979"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA014760":null,"HPA014968":null,"HPA014979":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PLS1","Gene synonym":[],"Ensembl":"ENSG00000120756","Gene description":"Plastin 1","Uniprot":["Q14651"],"Chromosome":"3","Position":"142596393-142713664","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"intestine":"296.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"477.2","Enterocytes":"613.3","Foveolar cells":"260.6","Goblet cells":"291.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"613.3","Goblet cells":"291.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"2.6","NK-cells":"3.0","T-cells":"2.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Colon - Colon enterocytes","Liver - Hepatocytes","Lung - Alveolar cells type 2","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"45098234.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"50509418.9"},"Antibody":["HPA000895","HPA055744","HPA061936"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"28000000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA000895":null,"HPA055744":null,"HPA061936":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.51e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.69e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"PLSCR2","Gene synonym":[],"Ensembl":"ENSG00000163746","Gene description":"Phospholipid scramblase 2","Uniprot":["Q9NRY7"],"Chromosome":"3","Position":"146391421-146495991","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"12.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"300.2","Late primary spermatocytes":"120.8","Late spermatids":"437.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"437.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"5.8"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051352"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Endoplasmic reticulum","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Endoplasmic reticulum","Vesicles"],"Antibody RRID":{"HPA051352":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PMM1","Gene synonym":["Sec53"],"Ensembl":"ENSG00000100417","Gene description":"Phosphomannomutase 1","Uniprot":["Q92871"],"Chromosome":"22","Position":"41576900-41589871","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Isomerase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Esophageal apical cells":"878.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"878.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA030712":null,"HPA074950":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.81e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.12e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.87e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"PMS1","Gene synonym":["MLH2","PMSL1"],"Ensembl":"ENSG00000064933","Gene description":"PMS1 homolog 1, mismatch repair system component","Uniprot":["P54277"],"Chromosome":"2","Position":"189784085-189877629","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":["Hereditary nonpolyposis colorectal cancer","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"45.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"506.1","Late primary spermatocytes":"327.1","Late spermatids":"992.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"992.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":16,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA031013":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.84e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.42e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"}},{"Gene":"PNLDC1","Gene synonym":["dJ195P10.2","FLJ40240","Trimmer"],"Ensembl":"ENSG00000146453","Gene description":"PARN like ribonuclease domain containing exonuclease 1","Uniprot":["Q8NA58"],"Chromosome":"6","Position":"159800249-159820704","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted membrane proteins"],"Biological process":["Nonsense-mediated mRNA decay"],"Molecular function":["Exonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"3.6","testis":"7.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Oocytes":"280.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Oocytes":"280.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"4.3"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"16.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"1.5","Sarcoma":"2.0"},"RNA tissue cell type enrichment":["Pancreas - Ductal cells","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"570089","Protein cell type specific Intensity":{"Oocytes":"57008934.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"253","Protein tissue specific Intensity":{"intestine":"25258.0"},"Antibody":["HPA052026"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052026":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"}},{"Gene":"PNMA1","Gene synonym":["MA1"],"Ensembl":"ENSG00000176903","Gene description":"PNMA family member 1","Uniprot":["Q8ND90"],"Chromosome":"14","Position":"73711783-73714384","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Tumor antigen"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"73.4","Late primary spermatocytes":"145.5","Late spermatids":"81.5","Peritubular myoid cells":"75.2","Platelets":"344.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"344.2","Spermatogenic cell types":"145.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":129,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA003817":null,"HPA015007":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"}},{"Gene":"PNPLA6","Gene synonym":["iPLA2delta","NTE","SPG39","sws"],"Ensembl":"ENSG00000032444","Gene description":"Patatin like phospholipase domain containing 6","Uniprot":["Q8IY17"],"Chromosome":"19","Position":"7534004-7561764","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid degradation","Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Dwarfism","Hereditary spastic paraplegia","Hypogonadotropic hypogonadism","Intellectual disability","Neurodegeneration","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Kupffer cells":"123.0","Late primary spermatocytes":"108.8","Late spermatids":"192.9","Oocytes":"96.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"123.0","Spermatogenic cell types":"192.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":5,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA007522":null,"HPA064773":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.06e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"}},{"Gene":"POC1A","Gene synonym":["DKFZP434C245","WDR51A"],"Ensembl":"ENSG00000164087","Gene description":"POC1 centriolar protein A","Uniprot":["Q8NBT0"],"Chromosome":"3","Position":"52075226-52154690","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Dwarfism","Hypotrichosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"11.9","testis":"16.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"26.9","Differentiating spermatogonia":"30.0","Early primary spermatocytes":"26.8","Early spermatids":"54.2","Erythrocyte progenitors":"40.8","Extravillous trophoblasts":"39.2","Late primary spermatocytes":"66.0","Late spermatids":"116.4","Megakaryocytes":"37.1","Migrating cytotrophoblasts":"33.9","Monocyte progenitors":"37.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"40.8","Spermatogenic cell types":"116.4","Trophoblast cells":"39.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"19677","Protein cell type specific Intensity":{"Fallopian tube cells":"1967711.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"272","Protein tissue specific Intensity":{"fallopian tube":"27155.0"},"Antibody":["HPA040600"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Flagellar centriole","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":31,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA040600":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.05e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.40e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.33e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.93e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.29e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"}},{"Gene":"POC1B","Gene synonym":["FLJ14923","TUWD12","WDR51B"],"Ensembl":"ENSG00000139323","Gene description":"POC1 centriolar protein B","Uniprot":["Q8TC44"],"Chromosome":"12","Position":"89419718-89526047","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Cone-rod dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"237.2","Late spermatids":"168.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"237.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"10146272.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"30566573.6","fallopian tube":"13249572.0","lung":"36803074.3","salivary gland":"38052184.0"},"Antibody":["HPA038841"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Cytosol","Flagellar centriole"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":28,"Subcellular main location":["Cytosol","Flagellar centriole"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA038841":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.13e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-3"}},{"Gene":"POC5","Gene synonym":["C5orf37","FLJ35779","hPOC5","MGC120442","MGC120443","MGC120444"],"Ensembl":"ENSG00000152359","Gene description":"POC5 centriolar protein","Uniprot":["Q8NA72"],"Chromosome":"5","Position":"75674124-75717448","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"74.7","Late primary spermatocytes":"151.5","Rod photoreceptor cells":"100.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"100.3","Spermatogenic cell types":"151.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"4731858.4","Fallopian tube cells":"7965241.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"40230","Protein tissue specific Intensity":{"fallopian tube":"4964407.3","lymphoid tissue":"3081663.3"},"Antibody":["HPA037510"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":20,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037510":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.32e-12"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"}},{"Gene":"POLB","Gene synonym":[],"Ensembl":"ENSG00000070501","Gene description":"DNA polymerase beta","Uniprot":["P06746"],"Chromosome":"8","Position":"42338454-42371808","Protein class":["Enzymes","FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","DNA replication","DNA synthesis"],"Molecular function":["DNA-binding","DNA-directed DNA polymerase","Lyase","Nucleotidyltransferase","Transferase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"176.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"315.8","Late primary spermatocytes":"137.5","Late spermatids":"225.5","pDCs":"516.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"516.7","Spermatogenic cell types":"315.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"189.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"cerebellum":"134.1"},"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"6249988.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"13278269.9"},"Antibody":["CAB011616","HPA049104","HPA069013","CAB080371"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 6: Plasmacytoid dendritic cells - Viral sensing & interferon response","Interactions":32,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB011616":null,"CAB080371":null,"HPA049104":null,"HPA069013":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.99e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"}},{"Gene":"POLD2","Gene synonym":[],"Ensembl":"ENSG00000106628","Gene description":"DNA polymerase delta 2, accessory subunit","Uniprot":["P49005"],"Chromosome":"7","Position":"44114631-44124358","Protein class":["Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA excision","DNA repair","DNA replication"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"239.8","Esophageal suprabasal cells":"208.2","Late spermatids":"495.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"495.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":26,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA026745":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.75e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.15e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.14e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.08e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"POLD3","Gene synonym":["KIAA0039","P66","P68","PPP1R128"],"Ensembl":"ENSG00000077514","Gene description":"DNA polymerase delta 3, accessory subunit","Uniprot":["Q15054"],"Chromosome":"11","Position":"74493851-74669117","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA excision","DNA repair","DNA replication"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":35,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA058846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.07e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"}},{"Gene":"POLG2","Gene synonym":["HP55","MTPOLB"],"Ensembl":"ENSG00000256525","Gene description":"DNA polymerase gamma 2, accessory subunit","Uniprot":["Q9UHN1"],"Chromosome":"17","Position":"64477785-64497054","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["DNA replication"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Primary mitochondrial disease","Progressive external ophthalmoplegia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"25178613.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"31455218.9"},"Antibody":["CAB017030","HPA023202","HPA078396"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":14,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"CAB017030":null,"HPA023202":null,"HPA078396":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.18e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.13e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"}},{"Gene":"POLH","Gene synonym":["RAD30A","XP-V"],"Ensembl":"ENSG00000170734","Gene description":"DNA polymerase eta","Uniprot":["Q9Y253"],"Chromosome":"6","Position":"43576185-43620523","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","DNA replication","DNA synthesis"],"Molecular function":["DNA-binding","DNA-directed DNA polymerase","Mutator protein","Nucleotidyltransferase","Transferase"],"Disease involvement":["Disease variant","Xeroderma pigmentosum"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA006721":null,"HPA026762":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.86e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.00e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"}},{"Gene":"POLK","Gene synonym":["DINB1","DINP","POLQ"],"Ensembl":"ENSG00000122008","Gene description":"DNA polymerase kappa","Uniprot":["Q9UBT6"],"Chromosome":"5","Position":"75511845-75609991","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","DNA replication","DNA synthesis"],"Molecular function":["DNA-binding","DNA-directed DNA polymerase","Mutator protein","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"2753","Protein cell type specific Intensity":{"Collecting ducts":"200649.9","Granulosa cells":"302665.0","Neurons":"453681.5","Pancreas epithelial cells":"144314.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA012035","HPA057303","HPA068117","HPA069375"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA012035":null,"HPA057303":null,"HPA068117":null,"HPA069375":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA076828":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.37e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"}},{"Gene":"POLR1B","Gene synonym":["FLJ10816","FLJ21921","RPA135","RPA2","Rpo1-2"],"Ensembl":"ENSG00000125630","Gene description":"RNA polymerase I subunit B","Uniprot":["Q9H9Y6"],"Chromosome":"2","Position":"112541915-112579818","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","RNA polymerase related proteins"],"Biological process":["Transcription"],"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"192.6","Late primary spermatocytes":"131.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"192.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":49,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037528":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.37e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"}},{"Gene":"POLR1D","Gene synonym":["AC19","MGC9850","RPA16","RPA9","RPAC2","RPO1-3"],"Ensembl":"ENSG00000186184","Gene description":"RNA polymerase I and III subunit D","Uniprot":["P0DPB5","P0DPB6"],"Chromosome":"13","Position":"27620742-27744237","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","RNA polymerase related proteins"],"Biological process":["Transcription"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1418.9","Late primary spermatocytes":"571.9","Late spermatids":"1306.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1418.9","Spermatogenic cell types":"1306.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039337"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":133,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA039337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.33e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.30e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":127,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA034694":null,"HPA046092":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.05e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"}},{"Gene":"POLR2I","Gene synonym":["hRPB14.5","RPB9"],"Ensembl":"ENSG00000105258","Gene description":"RNA polymerase II subunit I","Uniprot":["P36954"],"Chromosome":"19","Position":"36113709-36115213","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","RNA polymerase related proteins"],"Biological process":["Transcription"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1108.9","Late primary spermatocytes":"1112.5","Late spermatids":"3808.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3808.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":76,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA035632":null,"HPA045156":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"}},{"Gene":"POLR3C","Gene synonym":["C82","RPC3","RPC62"],"Ensembl":"ENSG00000186141","Gene description":"RNA polymerase III subunit C","Uniprot":["Q9BUI4"],"Chromosome":"1","Position":"145824053-145844402","Protein class":["Essential proteins","Metabolic proteins","Predicted intracellular proteins","RNA polymerase related proteins"],"Biological process":["Antiviral defense","Immunity","Innate immunity","Transcription"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"386.5","Late spermatids":"831.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"831.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2253018.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"450965.3"},"Antibody":["HPA027508","HPA027516"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":96,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA027508":null,"HPA027516":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.46e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.44e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.09e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"POM121L12","Gene synonym":["DKFZp564N2472"],"Ensembl":"ENSG00000221900","Gene description":"POM121 transmembrane nucleoporin like 12","Uniprot":["Q8N7R1"],"Chromosome":"7","Position":"53035633-53036925","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"125","RNA tissue specific nTPM":{"testis":"12.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Late primary spermatocytes":"33.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"117","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"33.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA027836":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"POM121L2","Gene synonym":["POM121-L"],"Ensembl":"ENSG00000158553","Gene description":"POM121 transmembrane nucleoporin like 2","Uniprot":["Q96KW2"],"Chromosome":"6","Position":"27285903-27312273","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"71","RNA tissue specific nTPM":{"testis":"7.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early primary spermatocytes":"8.4","Late primary spermatocytes":"21.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"21.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046150":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"POMP","Gene synonym":["C13orf12","HSPC014","UMP1"],"Ensembl":"ENSG00000132963","Gene description":"Proteasome maturation protein","Uniprot":["Q9Y244"],"Chromosome":"13","Position":"28659065-28678959","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":["Ichthyosis","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1075.8","Esophageal suprabasal cells":"972.3","Extravillous trophoblasts":"1242.2","Gastric progenitor cells":"975.4","Late primary spermatocytes":"1551.0","Syncytiotrophoblasts":"1163.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1551.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"207.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"807402.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"2454636.9","skeletal muscle":"2389514.6"},"Antibody":["HPA026995"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":78,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA026995":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.31e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.15e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"}},{"Gene":"POMT1","Gene synonym":["LGMD2K"],"Ensembl":"ENSG00000130714","Gene description":"Protein O-mannosyltransferase 1","Uniprot":["Q9Y6A1"],"Chromosome":"9","Position":"131502789-131523806","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Congenital muscular dystrophy","Disease variant","Dystroglycanopathy","Limb-girdle muscular dystrophy","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"84.5","Late primary spermatocytes":"76.8","Myonuclei":"72.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"72.8","Spermatogenic cell types":"84.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"1421663.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"214038.6"},"Antibody":["HPA065252"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":3,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA065252":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"}},{"Gene":"POP4","Gene synonym":["RPP29"],"Ensembl":"ENSG00000105171","Gene description":"POP4 homolog, ribonuclease P\/MRP subunit","Uniprot":["O95707"],"Chromosome":"19","Position":"29606283-29617237","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"147.4","Late primary spermatocytes":"121.8","Oocytes":"96.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"147.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":39,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA042748":null,"HPA064577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.07e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"}},{"Gene":"POPDC3","Gene synonym":["bA355M14.1","MGC22671","POP3"],"Ensembl":"ENSG00000132429","Gene description":"Popeye domain containing 3","Uniprot":["Q9HBV1"],"Chromosome":"6","Position":"105157900-105180014","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Limb-girdle muscular dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"heart muscle":"19.4","skeletal muscle":"76.4","tongue":"27.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"82.1","Early spermatids":"140.2","Gastric chief cells":"20.7","Late spermatids":"22.8","Myonuclei":"98.3","Myosatellite cells":"33.5","Oocytes":"23.0","Pancreatic islet cells":"22.9","Retinal pigment epithelial cells":"29.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"98.3","Spermatogenic cell types":"140.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"3.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Pancreas - Alpha cells","Prostate - Smooth muscle cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA012514"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Nucleoli","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA012514":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 8: Immune cells - Immune response","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":39,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB011193":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA056128":null,"HPA073101":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"}},{"Gene":"POU4F2","Gene synonym":["Brn-3b","BRN3B"],"Ensembl":"ENSG00000151615","Gene description":"POU class 4 homeobox 2","Uniprot":["Q12837"],"Chromosome":"4","Position":"146638893-146642474","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Apoptosis","Differentiation","Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Retinal ganglion cells":"15.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Neuronal cells":"15.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"lower rhombic lip":"6.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"22","RNA brain regional specific nTPM":{"medulla oblongata":"6.5","midbrain":"16.7","pons":"10.6"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.3","Gastric cancer":"2.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":64,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"POU5F2","Gene synonym":["FLJ25680","SPRM-1"],"Ensembl":"ENSG00000248483","Gene description":"POU domain class 5, transcription factor 2","Uniprot":["Q8N7G0"],"Chromosome":"5","Position":"93733220-93741600","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Paneth cells":"3.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Secretory gland support":"3.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA077615"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA077615":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PP2D1","Gene synonym":["C3orf48","FLJ25449"],"Ensembl":"ENSG00000183977","Gene description":"Protein phosphatase 2C like domain containing 1","Uniprot":["A8MPX8"],"Chromosome":"3","Position":"19979961-20012267","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"bone marrow":"1.8","testis":"6.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"60.1","Early spermatids":"527.2","Epicardial cells":"127.4","Late primary spermatocytes":"223.3","Late spermatids":"475.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"527.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Intermediate filaments"],"Antibody RRID":{"HPA036870":null,"HPA066083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPA2","Gene synonym":["FLJ20459"],"Ensembl":"ENSG00000138777","Gene description":"Inorganic pyrophosphatase 2","Uniprot":["Q9H2U2"],"Chromosome":"4","Position":"105369077-105474067","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"152.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"85000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":10,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA030888":null,"HPA031671":null,"HPA031672":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.94e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"}},{"Gene":"PPEF1","Gene synonym":["PPEF","PPP7CA"],"Ensembl":"ENSG00000086717","Gene description":"Protein phosphatase with EF-hand domain 1","Uniprot":["O14829"],"Chromosome":"X","Position":"18675909-18827921","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"8.9","breast":"3.9","testis":"13.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"67.1","Late primary spermatocytes":"42.1","Late spermatids":"257.1","Neutrophil progenitors":"28.2","Sertoli cells":"19.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"257.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"miscellaneous":"36.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Neuroblastoma":"5.4","Uterine cancer":"1.6"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"18861","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2397219.2","Microglia and Neuropil":"2411311.2","Neurons":"849790.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1986","Protein tissue specific Intensity":{"cerebral cortex":"198559.1"},"Antibody":["HPA034577"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Plasma membrane","Cytokinetic bridge"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":5,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytokinetic bridge"],"Antibody RRID":{"HPA034577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.88e-4"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPEF2","Gene synonym":["PPP7CB"],"Ensembl":"ENSG00000156194","Gene description":"Protein phosphatase with EF-hand domain 2","Uniprot":["O14830"],"Chromosome":"4","Position":"75859864-75902571","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"249","RNA tissue specific nTPM":{"retina":"221.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Rod photoreceptor cells":"1892.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"123","RNA single cell type group specific nCPM":{"Neuronal cells":"1892.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPFIA1","Gene synonym":["LIP.1","LIPRIN"],"Ensembl":"ENSG00000131626","Gene description":"PTPRF interacting protein alpha 1","Uniprot":["Q13136"],"Chromosome":"11","Position":"70270690-70385312","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"245.1","Bergmann glia":"208.6","Choroid plexus epithelial cells":"287.4","Distal convoluted tubule cells":"127.8","Early spermatids":"155.7","Microglia":"127.9","Proximal tubule cells":"138.7","Renal collecting duct intercalated cells":"145.9","Renal connecting tubule cells":"131.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"287.4","Ductal cells":"145.9","Glial cells":"245.1","Renal nephron cells":"138.7","Spermatogenic cell types":"155.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"3777084.9"},"Antibody":["CAB017032","HPA042271"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Focal adhesion sites","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":61,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Focal adhesion sites"],"Antibody RRID":{"CAB017032":null,"HPA042271":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.31e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.74e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"}},{"Gene":"PPFIA2","Gene synonym":[],"Ensembl":"ENSG00000139220","Gene description":"PTPRF interacting protein alpha 2","Uniprot":["O75334"],"Chromosome":"12","Position":"81257975-81759553","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"34.3","retina":"46.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"712.7","Brain excitatory neurons":"1143.9","Brain inhibitory neurons":"979.5","Cone photoreceptor cells":"602.4","Corticotrophs":"1523.5","Ependymal cells":"862.3","Lactotrophs":"448.1","Oligodendrocyte progenitor cells":"841.3","Oligodendrocytes":"521.1","Other brain neurons":"975.2","Retinal amacrine cells":"1392.7","Retinal bipolar cells":"491.0","Retinal ganglion cells":"459.7","Rod photoreceptor cells":"880.4","Thyrotrophs":"964.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"712.7","Ciliated cells":"862.3","Glial cells":"841.3","Neuronal cells":"1392.7","Pituitary endocrine cells":"1523.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"4705.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.2","Prostate Adenocarcinoma (TCGA)":"7.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"5.6","prostate cancer":"18.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pituitary gland - Corticotropes","Prostate - Smooth muscle cells","Spleen - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"34064737.8","Microglia and Neuropil":"42883212.5","Neurons":"23688507.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"373361","Protein tissue specific Intensity":{"cerebral cortex":"37336129.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.37e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPFIBP2","Gene synonym":["Cclp1"],"Ensembl":"ENSG00000166387","Gene description":"PPFIA binding protein 2","Uniprot":["Q8ND30"],"Chromosome":"11","Position":"7513298-7657127","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"252.9","Endometrial glandular cells":"255.4","Renal collecting duct intercalated cells":"287.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"287.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"176.1","committed oligodendrocyte precursor":"146.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":7,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA001935":null,"HPA003911":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.04e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.36e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.32e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.55e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"}},{"Gene":"PPIL6","Gene synonym":["bA425D10.6","dJ919F19.1","MGC41939","RSPH12"],"Ensembl":"ENSG00000185250","Gene description":"Peptidylprolyl isomerase like 6","Uniprot":["Q8IXY8"],"Chromosome":"6","Position":"109390215-109441171","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"33.5","testis":"17.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"204.4","Early spermatids":"344.1","Endometrial ciliated cells":"378.1","Ependymal cells":"368.7","Epididymal efferent duct ciliated cells":"394.1","Fallopian tube ciliated cells":"530.1","Late primary spermatocytes":"423.8","Respiratory ciliated cells":"525.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"530.1","Spermatogenic cell types":"423.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"153.8","ependymal cell":"421.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"31765","Protein cell type specific Intensity":{"Fallopian tube cells":"3176517.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1965","Protein tissue specific Intensity":{"fallopian tube":"196533.4"},"Antibody":["HPA036717","HPA058165"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA036717":null,"HPA058165":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"}},{"Gene":"PPM1A","Gene synonym":["MGC9201","PP2CA","PP2Calpha"],"Ensembl":"ENSG00000100614","Gene description":"Protein phosphatase, Mg2+\/Mn2+ dependent 1A","Uniprot":["P35813"],"Chromosome":"14","Position":"60245752-60299087","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"134.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"533.5","Late spermatids":"999.2","Neutrophils":"413.6","Platelets":"410.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"999.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029209"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"900000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":29,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA029209":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.12e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"}},{"Gene":"PPM1D","Gene synonym":["PP2C-DELTA","Wip1"],"Ensembl":"ENSG00000170836","Gene description":"Protein phosphatase, Mg2+\/Mn2+ dependent 1D","Uniprot":["O15297"],"Chromosome":"17","Position":"60600193-60666280","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Autism spectrum disorder","Cancer-related genes","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"140","Protein cell type specific Intensity":{"Granulosa cells":"20732.0","Macrophages":"12199.1","T-cells":"9028.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA022277","HPA061848"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA022277":null,"HPA061848":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.04e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.88e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"PPM1E","Gene synonym":["CaMKP-N","KIAA1072","POPX1","PP2CH"],"Ensembl":"ENSG00000175175","Gene description":"Protein phosphatase, Mg2+\/Mn2+ dependent 1E","Uniprot":["Q8WY54"],"Chromosome":"17","Position":"58755854-58985179","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"adrenal gland":"5.1","brain":"11.7","retina":"20.7","testis":"6.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"361.2","Brain excitatory neurons":"657.4","Brain inhibitory neurons":"265.9","Cone photoreceptor cells":"1397.3","Early primary spermatocytes":"438.3","Early spermatids":"257.8","Ependymal cells":"268.3","Gonadotrophs":"366.7","Other brain neurons":"400.7","Retinal bipolar cells":"550.2","Retinal horizontal cells":"1254.1","Rod photoreceptor cells":"386.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"361.2","Neuronal cells":"1397.3","Pituitary endocrine cells":"366.7","Spermatogenic cell types":"438.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"1649.8","hippocampal dentate gyrus":"2643.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.4","Prostate Adenocarcinoma (TCGA)":"4.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"15.0","prostate cancer":"7.8"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Colon - Colon enteroendocrine cells","Lung - Respiratory ciliated cells","Pancreas - Beta cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"9925642.5","Microglia and Neuropil":"10495595.8","Neurons":"11291135.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"5302533.4"},"Antibody":["HPA018462","HPA019263"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":4,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA018462":null,"HPA019263":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPM1G","Gene synonym":["PP2CG","PP2Cgamma"],"Ensembl":"ENSG00000115241","Gene description":"Protein phosphatase, Mg2+\/Mn2+ dependent 1G","Uniprot":["O15355"],"Chromosome":"2","Position":"27381195-27409591","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"232.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"1469.0","Late primary spermatocytes":"1906.4","Late spermatids":"5463.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5463.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"30000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":108,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA035530":null,"HPA035531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.30e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.08e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.34e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"}},{"Gene":"PPP1CC","Gene synonym":["PP1C","PP1gamma"],"Ensembl":"ENSG00000186298","Gene description":"Protein phosphatase 1 catalytic subunit gamma","Uniprot":["P36873"],"Chromosome":"12","Position":"110719680-110742939","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","Carbohydrate metabolism","Cell cycle","Cell division","Glycogen metabolism"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"574.2","Late primary spermatocytes":"843.3","Late spermatids":"1272.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1272.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2200000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":222,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"CAB022645":null,"CAB079921":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.76e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.40e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.30e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"}},{"Gene":"PPP1R11","Gene synonym":["CFAP255","HCG-V","HCGV","TCTE5","Tctex5"],"Ensembl":"ENSG00000204619","Gene description":"Protein phosphatase 1 regulatory inhibitor subunit 11","Uniprot":["O60927"],"Chromosome":"6","Position":"30066709-30070333","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Protein phosphatase inhibitor","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Late spermatids":"888.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"48","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"888.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"270","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"26604.8","Collecting ducts":"18211.0","Microglia and Neuropil":"36538.7","Proximal tubules":"26533.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043266","HPA060174"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":21,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA043266":null,"HPA060174":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"}},{"Gene":"PPP1R12C","Gene synonym":["AAVS1","DKFZP434D0412","LENG3","MBS85","p84","p85"],"Ensembl":"ENSG00000125503","Gene description":"Protein phosphatase 1 regulatory subunit 12C","Uniprot":["Q9BZL4"],"Chromosome":"19","Position":"55090914-55117637","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Vascular smooth muscle cells":"89.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Skeletal myofibers":"103997713.7"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043532"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043532":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.50e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"PPP1R13B","Gene synonym":["ASPP1","KIAA0771","p53BP2-like","p85"],"Ensembl":"ENSG00000088808","Gene description":"Protein phosphatase 1 regulatory subunit 13B","Uniprot":["Q96KQ4"],"Chromosome":"14","Position":"103733195-103847575","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Heart muscle - Cardiomyocytes","Prostate - Prostate glandular cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"4656936.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"602279.7"},"Antibody":["HPA006394","CAB015454"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":77,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB015454":null,"HPA006394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.38e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.68e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Golgi apparatus"],"Antibody RRID":{"HPA055043":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.77e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPP1R2","Gene synonym":["IPP2","PPP1R2A"],"Ensembl":"ENSG00000184203","Gene description":"Protein phosphatase 1 regulatory inhibitor subunit 2","Uniprot":["P41236"],"Chromosome":"3","Position":"195514428-195543386","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism","Glycogen metabolism"],"Molecular function":["Protein phosphatase inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"505.1","Late primary spermatocytes":"466.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"33000","Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA043729":null,"HPA059420":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.70e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"PPP1R27","Gene synonym":["DYSFIP1","toonin"],"Ensembl":"ENSG00000182676","Gene description":"Protein phosphatase 1 regulatory subunit 27","Uniprot":["Q86WC6"],"Chromosome":"17","Position":"81833492-81835050","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protein phosphatase inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"26","RNA tissue specific nTPM":{"skeletal muscle":"1144.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"5.4","Gonadotrophs":"3.6","Late primary spermatocytes":"9.9","Myonuclei":"5.2","Thymic myoid cells":"10.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Myocytes":"5.2","Pituitary endocrine cells":"3.6","Spermatogenic cell types":"9.9","Stromal cells":"10.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"4.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"218","RNA cell line specific nTPM":{"Leukemia":"66.4"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":10,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042227":null,"HPA048632":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA043729":null,"HPA059420":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":3,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA039068":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.25e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"}},{"Gene":"PPP1R42","Gene synonym":["dtr","LRRC67","TLLR"],"Ensembl":"ENSG00000178125","Gene description":"Protein phosphatase 1 regulatory subunit 42","Uniprot":["Q7Z4L9"],"Chromosome":"8","Position":"66964099-67056604","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"fallopian tube":"5.1","testis":"8.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"136.9","Choroid plexus epithelial cells":"196.3","Early primary spermatocytes":"125.4","Endometrial ciliated cells":"109.8","Ependymal cells":"646.7","Epididymal efferent duct ciliated cells":"162.0","Fallopian tube ciliated cells":"243.3","Late primary spermatocytes":"283.2","Respiratory ciliated cells":"323.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"646.7","Myocytes":"136.9","Spermatogenic cell types":"283.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"191.1","ependymal cell":"671.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024313","HPA027983","HPA028628"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA024313":null,"HPA027983":null,"HPA028628":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PPP1R7","Gene synonym":["sds22"],"Ensembl":"ENSG00000115685","Gene description":"Protein phosphatase 1 regulatory subunit 7","Uniprot":["Q15435"],"Chromosome":"2","Position":"241149576-241183652","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"980.7","Esophageal apical cells":"444.7","Late primary spermatocytes":"860.1","Late spermatids":"2387.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2387.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034500","HPA034501"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1400000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":50,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA034500":null,"HPA034501":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.49e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.84e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.01e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"}},{"Gene":"PPP2R1B","Gene synonym":["PP2A-Abeta","PR65B"],"Ensembl":"ENSG00000137713","Gene description":"Protein phosphatase 2 scaffold subunit Abeta","Uniprot":["P30154"],"Chromosome":"11","Position":"111726908-111766389","Protein class":["Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"152.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"702.9","Early spermatids":"287.6","Late primary spermatocytes":"359.8","Late spermatids":"218.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adipocytes":"702.9","Spermatogenic cell types":"359.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"10223694.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"22222951.4","fallopian tube":"9444291.7","skin":"24285250.4"},"Antibody":["CAB004034","HPA018908"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":79,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB004034":null,"HPA018908":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.95e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.63e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"}},{"Gene":"PPP2R2C","Gene synonym":["B55gamma","IMYPNO","MGC33570","PR52","PR55G"],"Ensembl":"ENSG00000074211","Gene description":"Protein phosphatase 2 regulatory subunit Bgamma","Uniprot":["Q9Y2T4"],"Chromosome":"4","Position":"6320578-6563600","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"112.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"97.4","Brain excitatory neurons":"200.1","Brain inhibitory neurons":"254.9","Corticotrophs":"98.6","Early spermatids":"108.1","Ependymal cells":"127.0","Esophageal apical cells":"337.9","Esophageal suprabasal cells":"104.6","Gonadotrophs":"120.9","Lactotrophs":"154.7","Late spermatids":"318.5","Ocular epithelial cells":"110.5","Other brain neurons":"140.7","Retinal ganglion cells":"208.6","Thyrotrophs":"127.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"337.9","Neuronal cells":"254.9","Pituitary endocrine cells":"154.7","Spermatogenic cell types":"318.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"35.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Heart muscle - Cardiomyocytes","Pancreas - Alpha cells","Pancreas - Beta cells","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"7708","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"804063.7","Microglia and Neuropil":"540026.0","Neurons":"968190.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"226585","Protein tissue specific Intensity":{"cerebral cortex":"22658464.9"},"Antibody":["HPA042122","HPA042770","HPA060473"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":24,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042122":null,"HPA042770":null,"HPA060473":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"}},{"Gene":"PPP2R3C","Gene synonym":["C14orf10","FLJ20644","G4-1","G5PR"],"Ensembl":"ENSG00000092020","Gene description":"Protein phosphatase 2 regulatory subunit B''gamma","Uniprot":["Q969Q6"],"Chromosome":"14","Position":"35085467-35122517","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cone-rod dystrophy","Deafness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"467.0","Epicardial cells":"1244.0","Late primary spermatocytes":"615.6","Late spermatids":"286.4","Neutrophils":"387.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1244.0","Neutrophils":"387.8","Spermatogenic cell types":"615.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Golgi apparatus","Actin filaments","Primary cilium","Cytosol"],"Antibody RRID":{"HPA040835":null,"HPA058834":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"}},{"Gene":"PPP2R5A","Gene synonym":["B56A","B56alpha","PR61A"],"Ensembl":"ENSG00000066027","Gene description":"Protein phosphatase 2 regulatory subunit B'alpha","Uniprot":["Q15172"],"Chromosome":"1","Position":"212285410-212361853","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"902.4","Neutrophil progenitors":"631.6","Neutrophils":"500.6","Renal collecting duct intercalated cells":"353.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"631.6","Spermatogenic cell types":"902.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Lung - Alveolar cells type 1","Prostate - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059288","HPA078841"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":51,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA059288":null,"HPA078841":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.60e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.84e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":28,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA027553":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"}},{"Gene":"PPP2R5E","Gene synonym":["B56E","B56epsilon"],"Ensembl":"ENSG00000154001","Gene description":"Protein phosphatase 2 regulatory subunit B'epsilon","Uniprot":["Q16537"],"Chromosome":"14","Position":"63371364-63543377","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"10980584.3","Microglia and Neuropil":"12994658.9","Neurons":"9742612.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"6978634.6"},"Antibody":["HPA006034","CAB072342"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":34,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"CAB072342":null,"HPA006034":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.71e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.96e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.64e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"}},{"Gene":"PPP3CC","Gene synonym":["CALNA3","PP2Bgamma"],"Ensembl":"ENSG00000120910","Gene description":"Protein phosphatase 3 catalytic subunit gamma","Uniprot":["P48454"],"Chromosome":"8","Position":"22440819-22541142","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Calmodulin-binding","Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"490.1","Cone photoreceptor cells":"428.5","Myonuclei":"778.4","Rod photoreceptor cells":"461.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"778.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Calyx"],"Antibody RRID":{"CAB024950":null,"HPA023396":null,"HPA074370":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.06e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.01e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":7,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Primary cilium","Cytosol"],"Antibody RRID":{"HPA047157":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":14,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Actin filaments","Perinuclear theca","Calyx","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA040905":null,"HPA041089":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"PPP4R4","Gene synonym":["CFAP14","KIAA1622","PP4R4"],"Ensembl":"ENSG00000119698","Gene description":"Protein phosphatase 4 regulatory subunit 4","Uniprot":["Q6NUP7"],"Chromosome":"14","Position":"94146128-94279734","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"15.1","testis":"7.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Astrocytes":"79.6","Bergmann glia":"57.3","Brain excitatory neurons":"103.1","Brain inhibitory neurons":"128.9","Ependymal cells":"33.1","Oligodendrocyte progenitor cells":"35.4","Other brain neurons":"78.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"33.1","Glial cells":"79.6","Neuronal cells":"128.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"9.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Primary cilium","Basal body"],"Antibody RRID":{"HPA041866":null,"HPA050321":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"170000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":59,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA050940":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.81e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"}},{"Gene":"PPP6R1","Gene synonym":["KIAA1115","SAP190","SAPS1"],"Ensembl":"ENSG00000105063","Gene description":"Protein phosphatase 6 regulatory subunit 1","Uniprot":["Q9UPN7"],"Chromosome":"19","Position":"55229779-55259017","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"236.7","Late primary spermatocytes":"87.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"236.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"28.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"14769165.6","T-cells":"15788095.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"19289394.3"},"Antibody":["HPA043989","HPA063681"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6200","Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":50,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA043989":null,"HPA063681":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.84e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"PPP6R2","Gene synonym":["dJ579N16.1","KIAA0685","SAP190","SAPS2"],"Ensembl":"ENSG00000100239","Gene description":"Protein phosphatase 6 regulatory subunit 2","Uniprot":["O75170"],"Chromosome":"22","Position":"50343304-50445090","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":22,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Cytoplasmic bodies"],"Antibody RRID":{"HPA030656":null,"HPA075438":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051066":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRB3","Gene synonym":["PRG"],"Ensembl":"ENSG00000197870","Gene description":"Proline rich protein BstNI subfamily 3","Uniprot":["Q04118"],"Chromosome":"12","Position":"11265914-11269707","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"1931","RNA tissue specific nTPM":{"salivary gland":"13016.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"14","RNA single cell type specific nCPM":{"Salivary acinar cells":"13838.1","Salivary myoepithelial cells":"4669.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Acinar cells":"13838.1","Secretory gland support":"4669.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"1.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"2.8","Lung Adenocarcinoma (TCGA)":"1.6","Lung Squamous Cell Carcinoma (TCGA)":"2.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRCP","Gene synonym":["HUMPCP","PCP"],"Ensembl":"ENSG00000137509","Gene description":"Prolylcarboxypeptidase","Uniprot":["P42785"],"Chromosome":"11","Position":"82822936-82970584","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"243.7","cDC":"210.4","Kupffer cells":"375.1","Neutrophils":"328.4","Vascular endothelial cells":"213.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"375.1","Neutrophils":"328.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"269.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Macrophages","Spleen - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"28078507.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA017065","HPA071115"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 28: Liver & Adrenal gland - Secretion","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 44: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":7,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA017065":null,"HPA071115":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.28e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"PRICKLE1","Gene synonym":["EPM1B","FLJ31937","RILP"],"Ensembl":"ENSG00000139174","Gene description":"Prickle planar cell polarity protein 1","Uniprot":["Q96MT3"],"Chromosome":"12","Position":"42456757-42590355","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"241.7","Brain inhibitory neurons":"174.7","Corticotrophs":"245.3","Endometrial stromal cells":"297.2","Fibro-adipogenic progenitors":"570.6","Oligodendrocyte progenitor cells":"209.0","Oligodendrocytes":"186.8","Retinal bipolar cells":"228.1","Retinal ganglion cells":"413.3","Salivary ionocytes":"174.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Fibro-adipogenic progenitors":"570.6","Neuronal cells":"413.3","Stromal cells":"297.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"11.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"11.6","granulocytes":"4.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adrenal gland - Fibroblasts","Kidney - Fibroblasts","Liver - Hepatic stellate cells","Prostate - Fibroblasts","Skeletal muscle - Fibroblasts","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"759","Protein cell type specific Intensity":{"Microglia and Neuropil":"69785.2","Neurons":"82013.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001379"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Basal body","Cytosol"],"Antibody RRID":{"HPA001379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.00e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"}},{"Gene":"PRKAA1","Gene synonym":["AMPKa1"],"Ensembl":"ENSG00000132356","Gene description":"Protein kinase AMP-activated catalytic subunit alpha 1","Uniprot":["Q13131"],"Chromosome":"5","Position":"40759389-40798374","Protein class":["Enzymes","FDA approved drug targets","Predicted intracellular proteins"],"Biological process":["Autophagy","Biological rhythms","Cholesterol biosynthesis","Cholesterol metabolism","Fatty acid biosynthesis","Fatty acid metabolism","Host-virus interaction","Lipid biosynthesis","Lipid metabolism","Steroid biosynthesis","Steroid metabolism","Sterol biosynthesis","Sterol metabolism","Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":["Chromatin regulator","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"276.6","Late primary spermatocytes":"263.0","Late spermatids":"707.5","Neutrophil progenitors":"279.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"707.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"76130536.0"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB005050","HPA035409","HPA064946"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":90,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Primary cilium","Basal body","Cytosol"],"Antibody RRID":{"CAB005050":null,"HPA035409":null,"HPA064946":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"}},{"Gene":"PRKACG","Gene synonym":["PKACg"],"Ensembl":"ENSG00000165059","Gene description":"Protein kinase cAMP-activated catalytic subunit gamma","Uniprot":["P22612"],"Chromosome":"9","Position":"69012504-69014113","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"230","RNA tissue specific nTPM":{"testis":"23.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"20","RNA single cell type specific nCPM":{"Early spermatids":"72.1","Late primary spermatocytes":"119.3","Late spermatids":"119.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"132","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"119.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":20,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Microtubules","Cytokinetic bridge","Primary cilium","Basal body"],"Antibody RRID":{"CAB004530":null,"HPA071185":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRKAR2A","Gene synonym":["PRKAR2"],"Ensembl":"ENSG00000114302","Gene description":"Protein kinase cAMP-dependent type II regulatory subunit alpha","Uniprot":["P13861"],"Chromosome":"3","Position":"48744597-48847874","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"81.8","testis":"78.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1048.8","Late spermatids":"1852.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1852.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"72000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":71,"Subcellular main location":["Centriolar satellite","Basal body","Mid piece"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"CAB005023":null,"HPA038268":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.54e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"}},{"Gene":"PRKD3","Gene synonym":["EPK2","PRKCN"],"Ensembl":"ENSG00000115825","Gene description":"Protein kinase D3","Uniprot":["O94806"],"Chromosome":"2","Position":"37250502-37324833","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Melanocytes":"342.2","Rod photoreceptor cells":"285.2","Somatotrophs":"250.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"225.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":4,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm","Vesicles","Basal body"],"Antibody RRID":{"HPA029529":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"}},{"Gene":"PRKN","Gene synonym":["AR-JP","PARK2","parkin","PDJ"],"Ensembl":"ENSG00000185345","Gene description":"Parkin RBR E3 ubiquitin protein ligase","Uniprot":["O60260"],"Chromosome":"6","Position":"161347417-162727775","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Autophagy","Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Neurodegeneration","Parkinson disease","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"26.6","tongue":"14.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"1152.0","Cardiomyocytes":"1330.4","Myonuclei":"1513.7","Renal collecting duct intercalated cells":"1171.7","Sertoli cells":"1217.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"1513.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"10.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Rhabdoid":"14.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1088946.8"},"Antibody":["CAB016257","HPA036012"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":1427,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB016257":null,"HPA036012":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.21e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.88e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"}},{"Gene":"PRKRA","Gene synonym":["DYT16","HSD14","PACT","RAX"],"Ensembl":"ENSG00000180228","Gene description":"Protein activator of interferon induced protein kinase EIF2AK2","Uniprot":["O75569"],"Chromosome":"2","Position":"178431292-178451512","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","RNA-mediated gene silencing"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant","Dystonia","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"456.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"456.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"92997069.2"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004648","HPA034996","HPA034997"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":248,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB004648":null,"HPA034996":null,"HPA034997":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"}},{"Gene":"PRMT8","Gene synonym":["HRMT1L3","HRMT1L4"],"Ensembl":"ENSG00000111218","Gene description":"Protein arginine methyltransferase 8","Uniprot":["Q9NR22"],"Chromosome":"12","Position":"3381349-3593973","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"24.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"43.3","Brain inhibitory neurons":"102.0","Early primary spermatocytes":"38.1","Late primary spermatocytes":"32.6","Renal collecting duct intercalated cells":"35.9","Respiratory ciliated cells":"183.4","Respiratory deuterosomal cells":"29.0","Retinal amacrine cells":"72.5","Retinal bipolar cells":"67.2","Retinal ganglion cells":"30.9","Sertoli cells":"33.3","Transitional alveolar cells":"63.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"63.4","Ciliated cells":"183.4","Neuronal cells":"102.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"211.5","medium spiny neuron":"179.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"2.2","Thyroid Carcinoma (TCGA)":"4.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"1.6","thyroid cancer":"1.4"},"RNA tissue cell type enrichment":["Colon - Colon enteroendocrine cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2092303.6","Microglia and Neuropil":"3260487.2","Neurons":"3624592.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"76873","Protein tissue specific Intensity":{"cerebral cortex":"7687303.7"},"Antibody":["HPA039747","HPA069769"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039747":null,"HPA069769":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - 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Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"34364236.9","intestine":"13644835.9"},"Antibody":["HPA036844","HPA042537"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Microtubules","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":7,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA036844":null,"HPA042537":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.45e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.28e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"}},{"Gene":"PROK2","Gene synonym":["BV8","KAL4","MIT1","PK2"],"Ensembl":"ENSG00000163421","Gene description":"Prokineticin 2","Uniprot":["Q9HC23"],"Chromosome":"3","Position":"71771655-71785206","Protein class":["Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":["Biological rhythms"],"Molecular function":["Neuropeptide"],"Disease involvement":["Disease variant","Hypogonadotropic hypogonadism","Kallmann syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"60.9","lymphoid tissue":"20.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"13","RNA single cell type specific nCPM":{"Neutrophils":"1546.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Neutrophils":"1546.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"3.2","ependymal cell":"7.4","medium spiny neuron":"3.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"3.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"7","RNA brain regional specific nTPM":{"cerebral cortex":"30.8"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"50","RNA blood cell specific nTPM":{"neutrophil":"416.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"50","RNA blood lineage specific nTPM":{"granulocytes":"416.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"8.0","Myeloma":"5.7"},"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Heart muscle - Neutrophils","Liver - Neutrophils","Skeletal muscle - Neutrophils","Spleen - Neutrophils_2","Stomach - Neutrophils","Testis - Early spermatids","Thyroid gland - Neutrophils"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"6","RNA mouse brain regional specific nTPM":{"basal ganglia":"2.7","hypothalamus":"1.1","olfactory bulb":"3.5"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA041408"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Neuropeptide","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041408":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"PROKR2","Gene synonym":["dJ680N4.3","GPR73b","GPR73L1","GPRg2","KAL3","PKR2"],"Ensembl":"ENSG00000101292","Gene description":"Prokineticin receptor 2","Uniprot":["Q8NFJ6"],"Chromosome":"20","Position":"5299218-5316954","Protein class":["Disease related genes","G-protein coupled receptors","Human disease related genes","Plasma proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Disease variant","Hypogonadotropic hypogonadism","Kallmann syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"1.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Cardiomyocytes":"37.8","Salivary duct cells":"15.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ductal cells":"15.2","Myocytes":"37.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"2.1","deep-layer intratelencephalic":"1.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047281":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Adrenal medulla cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"197380.7","Fallopian tube cells":"149743.0","Pancreas epithelial cells":"163746.2","Pancreatic islets":"151081.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"1494641.4","Stomach":"2084079.3"},"Antibody":["HPA004922","CAB011525","HPA031053","CAB080375","CAB080376"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"51000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":7,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB011525":null,"CAB080375":null,"CAB080376":null,"HPA004922":null,"HPA031053":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 49: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB034225":null,"HPA055687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"PROSER3","Gene synonym":["C19orf55","FLJ30657"],"Ensembl":"ENSG00000167595","Gene description":"Proline and serine rich 3","Uniprot":["Q2NL68"],"Chromosome":"19","Position":"35758143-35771166","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"40.3","Respiratory ciliated cells":"52.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"52.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"10.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"PROX1","Gene synonym":[],"Ensembl":"ENSG00000117707","Gene description":"Prospero homeobox 1","Uniprot":["Q92786"],"Chromosome":"1","Position":"213983181-214041510","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Biological rhythms","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"liver":"81.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"220.4","Corticotrophs":"213.2","Hepatocytes":"424.3","Lymphatic endothelial cells":"611.7","Myosatellite cells":"182.1","Pancreatic duct cells":"167.1","Respiratory ionocytes":"177.8","Retinal bipolar cells":"310.4","Retinal horizontal cells":"548.9","Tuft cells":"149.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Endothelial cells":"611.7","Hepatocytes":"424.3","Neuronal cells":"548.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"244.6","hippocampal dentate gyrus":"215.1","oligodendrocyte":"156.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"21.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"15.3","Neuroblastoma":"24.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA000842":null,"HPA001030":null,"HPA027298":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.15e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"}},{"Gene":"PRPF18","Gene synonym":["hPrp18"],"Ensembl":"ENSG00000165630","Gene description":"Pre-mRNA processing factor 18","Uniprot":["Q99633"],"Chromosome":"10","Position":"13586939-13668445","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"687919.8","Oocytes":"494950.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"2173688.9","fallopian tube":"1661673.1"},"Antibody":["HPA037599","HPA047950"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":65,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037599":null,"HPA047950":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.46e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.16e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"}},{"Gene":"PRPH","Gene synonym":["NEF4","PRPH1"],"Ensembl":"ENSG00000135406","Gene description":"Peripherin","Uniprot":["P41219"],"Chromosome":"12","Position":"49295147-49298686","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Amyotrophic lateral sclerosis","Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"30.8","testis":"16.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"298.2","Late primary spermatocytes":"367.2","Late spermatids":"1452.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"35","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1452.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"1.2","splatter":"3.2"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.8","Pancreatic Adenocarcinoma (TCGA)":"7.0","Testicular Germ Cell Tumor (TCGA)":"10.4","Uterine Corpus Endometrial Carcinoma (TCGA)":"11.5"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"medulla oblongata":"100.9","pons":"105.4","white matter":"29.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"Neuroblastoma":"158.4","Rhabdoid":"80.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":79,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB002437":null,"HPA039277":null,"HPA063887":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-5"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"}},{"Gene":"PRPS1L1","Gene synonym":["PRPS3","PRPSL"],"Ensembl":"ENSG00000229937","Gene description":"Phosphoribosyl pyrophosphate synthetase 1 like 1","Uniprot":["P21108"],"Chromosome":"7","Position":"18026770-18027846","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Nucleotide biosynthesis"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"295","RNA tissue specific nTPM":{"testis":"29.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late primary spermatocytes":"276.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"291","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"276.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":20,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA051269":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRPSAP2","Gene synonym":["PAP41"],"Ensembl":"ENSG00000141127","Gene description":"Phosphoribosyl pyrophosphate synthetase associated protein 2","Uniprot":["O60256"],"Chromosome":"17","Position":"18840085-18931287","Protein class":["Predicted intracellular proteins"],"Biological process":["Nucleotide biosynthesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"252.7"},"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"79000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":20,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021881":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.22e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.34e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.82e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.56e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"}},{"Gene":"PRR15L","Gene synonym":["ATAD4","MGC11242"],"Ensembl":"ENSG00000167183","Gene description":"Proline rich 15 like","Uniprot":["Q9BU68"],"Chromosome":"17","Position":"47951967-47957883","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"167.7","pancreas":"99.0","stomach 1":"80.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"96.0","Cholangiocytes":"78.7","Colonocytes":"188.2","Enteric stem cells":"105.7","Enteric transient amplifying cells":"104.7","Enterocytes":"242.7","Gastric chief cells":"67.7","Goblet cells":"120.2","Paneth cells":"89.0","Parietal cells":"132.6","Salivary duct cells":"81.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"242.7","Gastric glandular cells":"132.6","Goblet cells":"120.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"3.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"8","RNA brain regional specific nTPM":{"choroid plexus":"22.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"50.6","colorectal cancer":"47.9","Gastric cancer":"39.1"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA022918":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.34e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"PRR27","Gene synonym":["C4orf40"],"Ensembl":"ENSG00000187533","Gene description":"Proline rich 27","Uniprot":["Q6MZM9"],"Chromosome":"4","Position":"70133616-70176799","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"955","RNA tissue specific nTPM":{"salivary gland":"1039.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Lacrimal acinar cells":"403.1","Salivary acinar cells":"956.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Acinar cells":"956.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"thalamic excitatory":"1.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"831468.2","Distal tubules":"399589.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"192338578.5"},"Antibody":["HPA036150","HPA036151"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to digestive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036150":null,"HPA036151":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA051264":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRRC2A","Gene synonym":["BAT2","D6S51E","G2"],"Ensembl":"ENSG00000204469","Gene description":"Proline rich coiled-coil 2A","Uniprot":["P48634"],"Chromosome":"6","Position":"31620715-31637771","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"53.9","Podocytes":"52.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":37,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"CAB026383":null,"HPA046791":null,"HPA066501":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.08e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA006607":null,"HPA026808":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.99e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRSS54","Gene synonym":["CT67","FLJ25339","KLKBL4"],"Ensembl":"ENSG00000103023","Gene description":"Serine protease 54","Uniprot":["Q6PEW0"],"Chromosome":"16","Position":"58279997-58295047","Protein class":["Enzymes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Serine protease homolog"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"286","RNA tissue specific nTPM":{"testis":"38.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"21","RNA single cell type specific nCPM":{"Early spermatids":"674.7","Late primary spermatocytes":"247.1","Late spermatids":"291.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"36","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"674.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"4.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"1.1","Uterine Corpus Endometrial Carcinoma (TCGA)":"2.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041549":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"}},{"Gene":"PRSS55","Gene synonym":["CT153","T-SP1","UNQ9391"],"Ensembl":"ENSG00000184647","Gene description":"Serine protease 55","Uniprot":["Q6UWB4"],"Chromosome":"8","Position":"10525532-10554166","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"54","RNA tissue specific nTPM":{"testis":"26.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"174.1","Late primary spermatocytes":"101.5","Late spermatids":"49.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"174.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA1-3":"12.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027977"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Acrosome"],"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA027977":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PRTG","Gene synonym":["FLJ25756","IGDCC5"],"Ensembl":"ENSG00000166450","Gene description":"Protogenin","Uniprot":["Q2VWP7"],"Chromosome":"15","Position":"55611544-55743152","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"9.6","thyroid gland":"10.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"95.7","Alveolar cells type 2":"126.1","Bergmann glia":"173.0","Cone photoreceptor cells":"287.7","Distal convoluted tubule cells":"85.6","Endometrial stromal cells":"86.6","Pituitary stem cells":"79.2","Renal collecting duct principal cells":"148.4","Renal connecting tubule cells":"104.6","Rod photoreceptor cells":"184.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"148.4","Glial cells":"173.0","Neuronal cells":"287.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"195.3","endothelial cell":"282.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"4.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"15","RNA cell line specific nTPM":{"testis cancer":"159.2"},"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Lung - Alveolar cells type 2","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"113","Protein cell type specific Intensity":{"Collecting ducts":"4641.5","Distal tubules":"11700.4","Oocytes":"17696.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA032137","HPA032138"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"HPA032137":null,"HPA032138":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"}},{"Gene":"PRUNE1","Gene synonym":["DRES-17","H-PRUNE","HTCD37","PRUNE"],"Ensembl":"ENSG00000143363","Gene description":"Prune exopolyphosphatase 1","Uniprot":["Q86TP1"],"Chromosome":"1","Position":"151008420-151035713","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Intellectual disability","Neurodegeneration","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"81.6","Late spermatids":"99.1","Megakaryocytes":"74.2","Platelets":"177.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"177.6","Spermatogenic cell types":"99.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"42000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":10,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA028411":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"PSD3","Gene synonym":["DKFZp761K1423","EFA6D","EFA6R","HCA67","KIAA0942"],"Ensembl":"ENSG00000156011","Gene description":"Pleckstrin and Sec7 domain containing 3","Uniprot":["Q9NYI0"],"Chromosome":"8","Position":"18527303-19084730","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"65.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"1567.7","Bergmann glia":"1487.7","Cardiomyocytes":"1236.3","Early spermatids":"1018.4","Foveolar cells":"965.5","Somatotrophs":"1346.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"1567.7","Glial cells":"1487.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Heart muscle - Cardiomyocytes","Skeletal muscle - Fibroblasts","Spleen - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"56524670.1","Microglia and Neuropil":"74481652.2","Neurons":"113828672.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"76263747.0","intestine":"21414276.0"},"Antibody":["HPA002455"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol","Calyx","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 18: Adrenal cortex cells - Steroidogensis","Interactions":7,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Cytosol","Calyx","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA002455":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.69e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"}},{"Gene":"PSENEN","Gene synonym":["PEN2"],"Ensembl":"ENSG00000205155","Gene description":"Presenilin enhancer, gamma-secretase subunit","Uniprot":["Q9NZ42"],"Chromosome":"19","Position":"35745600-35747519","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Notch signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"320.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"305.2","Epididymal efferent duct ciliated cells":"285.0","Fallopian tube ciliated cells":"428.1","Late primary spermatocytes":"469.2","Late spermatids":"115.0","Respiratory ciliated cells":"212.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"428.1","Spermatogenic cell types":"469.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"28.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047435"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":18,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047435":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.10e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.94e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.95e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.03e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"}},{"Gene":"PSKH1","Gene synonym":[],"Ensembl":"ENSG00000159792","Gene description":"Protein serine kinase H1","Uniprot":["P11801"],"Chromosome":"16","Position":"67893254-67929676","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Intrahepatic cholestasis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"50.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Smooth muscle cells","Skin - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053927","HPA062763"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Plasma membrane","Primary cilium","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":4,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Plasma membrane","Primary cilium","Cytosol"],"Antibody RRID":{"HPA053927":null,"HPA062763":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.28e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.05e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"}},{"Gene":"PSMA4","Gene synonym":["HC9","HsT17706"],"Ensembl":"ENSG00000041357","Gene description":"Proteasome 20S subunit alpha 4","Uniprot":["P25789"],"Chromosome":"15","Position":"78540405-78552417","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"555.5","Early spermatids":"693.2","Extravillous trophoblasts":"536.3","Late primary spermatocytes":"722.1","Migrating cytotrophoblasts":"538.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"722.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8300000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":170,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles","Connecting piece","Flagellar centriole","Mid piece"],"Antibody RRID":{"CAB004973":null,"HPA055466":null,"HPA060613":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.88e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.30e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.55e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.80e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"}},{"Gene":"PSMA6","Gene synonym":["IOTA","MGC22756","MGC2333","MGC23846","p27K","PROS27"],"Ensembl":"ENSG00000100902","Gene description":"Proteasome 20S subunit alpha 6","Uniprot":["P60900"],"Chromosome":"14","Position":"35278633-35317493","Protein class":["Enzymes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Astrocytes":"34.5","Bergmann glia":"36.1","Brain excitatory neurons":"48.7","Brain inhibitory neurons":"48.4","Choroid plexus epithelial cells":"46.4","Ependymal cells":"25.7","Microglia":"45.3","Oligodendrocyte progenitor cells":"41.6","Oligodendrocytes":"47.4","Other brain neurons":"57.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"46.4","Glial cells":"47.4","Neuronal cells":"57.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003049"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Primary cilium","Primary cilium tip","Cytosol","Perinuclear theca","Calyx","Connecting piece","Flagellar centriole","Mid piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":156,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Primary cilium tip","Cytosol","Perinuclear theca","Calyx","Connecting piece","Flagellar centriole","Mid piece","End piece"],"Antibody RRID":{"HPA003049":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.36e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.47e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"}},{"Gene":"PSMA8","Gene synonym":["MGC26605","PSMA7L"],"Ensembl":"ENSG00000154611","Gene description":"Proteasome 20S subunit alpha 8","Uniprot":["Q8TAA3"],"Chromosome":"18","Position":"26133852-26193355","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"15.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early primary spermatocytes":"288.2","Late primary spermatocytes":"126.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"288.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Gallbladder cancer":"3.6","lymphoma":"6.9","Myeloma":"3.9"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":21,"Subcellular main location":["Vesicles","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA071263":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"}},{"Gene":"PSMC1","Gene synonym":["p56","RPT2","S4"],"Ensembl":"ENSG00000100764","Gene description":"Proteasome 26S subunit, ATPase 1","Uniprot":["P62191"],"Chromosome":"14","Position":"90256527-90275429","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Deafness","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"294.5"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA000872","HPA016885"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":180,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA000872":null,"HPA016885":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"PSMC2","Gene synonym":["MSS1","Nbla10058","RPT1","S7"],"Ensembl":"ENSG00000161057","Gene description":"Proteasome 26S subunit, ATPase 2","Uniprot":["P35998"],"Chromosome":"7","Position":"103328570-103370346","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Syncytiotrophoblasts":"288.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"220000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":176,"Subcellular main location":["Cytosol","Cytoplasmic bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA019238":null,"HPA049621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"}},{"Gene":"PSMC3","Gene synonym":["RPT5","TBP-1","TBP1"],"Ensembl":"ENSG00000165916","Gene description":"Proteasome 26S subunit, ATPase 3","Uniprot":["P17980"],"Chromosome":"11","Position":"47418769-47426473","Protein class":["Disease related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":["Cataract","Deafness","Intellectual disability","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"315.0","Extravillous trophoblasts":"311.2","Late primary spermatocytes":"330.1","Late spermatids":"321.7","Syncytiotrophoblasts":"439.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"439.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006065"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"280000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":202,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA006065":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"}},{"Gene":"PSMC3IP","Gene synonym":["GT198","Hop2","HUMGT198A","TBPIP"],"Ensembl":"ENSG00000131470","Gene description":"PSMC3 interacting protein","Uniprot":["Q9P2W1"],"Chromosome":"17","Position":"42572310-42577831","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA recombination","Meiosis"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"24.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"34.6","Early primary spermatocytes":"110.0","Late primary spermatocytes":"70.1","Oocytes":"46.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"46.1","Spermatogenic cell types":"110.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"2.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044439":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.30e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.49e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.25e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"}},{"Gene":"PSMC4","Gene synonym":["MGC13687","MGC23214","MGC8570","MIP224","RPT3","S6","TBP-7","TBP7"],"Ensembl":"ENSG00000013275","Gene description":"Proteasome 26S subunit, ATPase 4","Uniprot":["P43686"],"Chromosome":"19","Position":"39971165-39981764","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"156.3","Hofbauer cells":"145.7","Late primary spermatocytes":"236.5","Late spermatids":"139.8","Syncytiotrophoblasts":"322.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"236.5","Trophoblast cells":"322.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA002044","HPA005471"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Basal body","Cytosol","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"190000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":191,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Vesicles","Basal body","Mid piece","Principal piece"],"Antibody RRID":{"HPA002044":null,"HPA005471":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.25e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.16e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.89e-5"}},{"Gene":"PSMC5","Gene synonym":["p45","p45\/SUG","RPT6","S8","SUG-1","SUG1","TBP10","TRIP1"],"Ensembl":"ENSG00000087191","Gene description":"Proteasome 26S subunit, ATPase 5","Uniprot":["P62195"],"Chromosome":"17","Position":"63827152-63832026","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"578.0","Late primary spermatocytes":"496.8","Late spermatids":"2133.5","Oocytes":"455.9","Syncytiotrophoblasts":"459.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2133.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA017871","HPA064293"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"83000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":235,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017871":null,"HPA064293":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.97e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.49e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.11e-5"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"}},{"Gene":"PSMD11","Gene synonym":["MGC3844","p44.5","Rpn6","S9"],"Ensembl":"ENSG00000108671","Gene description":"Proteasome 26S subunit, non-ATPase 11","Uniprot":["O00231"],"Chromosome":"17","Position":"32444379-32483319","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Syncytiotrophoblasts":"410.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"410.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"160000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":167,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Perinuclear theca","Principal piece"],"Antibody RRID":{"HPA042275":null,"HPA067433":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.33e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"}},{"Gene":"PSMD14","Gene synonym":["pad1","POH1","Rpn11"],"Ensembl":"ENSG00000115233","Gene description":"Proteasome 26S subunit, non-ATPase 14","Uniprot":["O00487"],"Chromosome":"2","Position":"161308425-161411717","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA002114","HPA003828"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":134,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA002114":null,"HPA003828":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.48e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.51e-4"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.34e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.36e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"}},{"Gene":"PSMD4","Gene synonym":["AF","AF-1","Rpn10","S5A"],"Ensembl":"ENSG00000159352","Gene description":"Proteasome 26S subunit ubiquitin receptor, non-ATPase 4","Uniprot":["P55036"],"Chromosome":"1","Position":"151254709-151267479","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"396.5","Late primary spermatocytes":"534.5","Syncytiotrophoblasts":"505.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"534.5","Trophoblast cells":"505.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"52000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":211,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB047300":null,"HPA038807":null,"HPA039252":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.30e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.96e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"97000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":167,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036921":null,"HPA036922":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.56e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.34e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"}},{"Gene":"PSMD7","Gene synonym":["MOV34","P40","Rpn8","S12"],"Ensembl":"ENSG00000103035","Gene description":"Proteasome 26S subunit, non-ATPase 7","Uniprot":["P51665"],"Chromosome":"16","Position":"74296814-74306288","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"417.4","Esophageal apical cells":"481.9","Syncytiotrophoblasts":"819.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"819.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB019379","HPA049824","HPA056069"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Acrosome","Equatorial segment","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"72000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":124,"Subcellular main location":["Nucleoplasm","Acrosome","Equatorial segment","Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"CAB019379":null,"HPA049824":null,"HPA056069":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.09e-4"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"}},{"Gene":"PSMD8","Gene synonym":["HIP6","HYPF","Nin1p","p31","Rpn12","S14"],"Ensembl":"ENSG00000099341","Gene description":"Proteasome 26S subunit, non-ATPase 8","Uniprot":["P48556"],"Chromosome":"19","Position":"38374563-38383850","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"667.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"644.1","Late primary spermatocytes":"646.2","Late spermatids":"1824.8","Syncytiotrophoblasts":"665.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1824.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006702","CAB021101"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"71000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":76,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"CAB021101":null,"HPA006702":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"}},{"Gene":"PSME3","Gene synonym":["Ki","PA28-gamma","PA28G","REG-GAMMA"],"Ensembl":"ENSG00000131467","Gene description":"Proteasome activator subunit 3","Uniprot":["P61289"],"Chromosome":"17","Position":"42824385-42843760","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Cell cycle","Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"301.4","Late spermatids":"177.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"301.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB008388","HPA012510"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":184,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Basal body","Cytosol"],"Antibody RRID":{"CAB008388":null,"HPA012510":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.41e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.08e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.60e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.73e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"}},{"Gene":"PSME3IP1","Gene synonym":["C16orf94","FAM192A","NIP30","PIP30"],"Ensembl":"ENSG00000172775","Gene description":"Proteasome activator subunit 3 interacting protein 1","Uniprot":["Q9GZU8"],"Chromosome":"16","Position":"57152466-57186116","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"240.8","Late spermatids":"344.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"344.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"1950679.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1785174.0"},"Antibody":["HPA054382","HPA059652"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":53,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA054382":null,"HPA059652":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.36e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"}},{"Gene":"PSME4","Gene synonym":["KIAA0077","PA200"],"Ensembl":"ENSG00000068878","Gene description":"Proteasome activator subunit 4","Uniprot":["Q14997"],"Chromosome":"2","Position":"53864069-53970993","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","DNA damage","DNA repair","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"53.7"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"1214748.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1392917.7","liver":"479554.2","lymphoid tissue":"689120.6"},"Antibody":["HPA060922"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"19000","Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":95,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA060922":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"}},{"Gene":"PSMF1","Gene synonym":["PI31"],"Ensembl":"ENSG00000125818","Gene description":"Proteasome inhibitor subunit 1","Uniprot":["Q92530"],"Chromosome":"20","Position":"1113240-1189415","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"6955.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"41","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6955.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"44348673.7"},"Antibody":["HPA041122","HPA041300"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"310000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":67,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041122":null,"HPA041300":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.99e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"}},{"Gene":"PSMG1","Gene synonym":["c21-LRP","DSCR2","LRPC21","PAC1"],"Ensembl":"ENSG00000183527","Gene description":"Proteasome assembly chaperone 1","Uniprot":["O95456"],"Chromosome":"21","Position":"39174769-39183488","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"37.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"539.1","Late primary spermatocytes":"1403.1","Oocytes":"350.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1403.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"28470831.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"24017251.7"},"Antibody":["HPA057193","HPA070225"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6900","Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":57,"Subcellular main location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA057193":null,"HPA070225":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":64,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041517":null,"HPA046741":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA045049":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":53,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038928":null,"HPA038929":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":159,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"CAB004076":null,"CAB080153":null,"CAB080155":null,"CAB080157":null,"HPA031335":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"}},{"Gene":"PTGER4","Gene synonym":["EP4"],"Ensembl":"ENSG00000171522","Gene description":"Prostaglandin E receptor 4","Uniprot":["P35408"],"Chromosome":"5","Position":"40679915-40693735","Protein class":["FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"81.0","pancreas":"51.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"135.5","Foveolar cells":"89.1","Goblet cells":"76.8","Hematopoietic stem cells":"115.5","Innate lymphoid cells":"169.8","Kupffer cells":"84.0","Macrophages":"99.8","Mast cells":"73.5","monocytes":"79.7","Neutrophils":"104.6","NK-cells":"135.9","Podocytes":"143.8","T-cells":"218.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Innate lymphoid cells":"169.8","T-cells":"218.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"leukocyte":"81.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA011226":null,"HPA012756":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"}},{"Gene":"PTGES3L","Gene synonym":[],"Ensembl":"ENSG00000267060","Gene description":"Prostaglandin E synthase 3 like","Uniprot":["E9PB15"],"Chromosome":"17","Position":"42968088-42980433","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"116.5","tongue":"88.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1.5","Bergmann glia":"1.3","Brain excitatory neurons":"3.3","Brain inhibitory neurons":"6.0","Choroid plexus epithelial cells":"1.6","Ependymal cells":"3.0","Megakaryocytes":"6.2","Oligodendrocyte progenitor cells":"1.0","Other brain neurons":"3.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"3.0","Glial cells":"1.5","Megakaryocytes":"6.2","Neuronal cells":"6.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"plasmacytoid DC":"4.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"4.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Adipose visceral - Smooth muscle cells","Colon - Smooth muscle cells","Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"32716","Protein tissue specific Intensity":{"skeletal muscle":"3271611.3"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"}},{"Gene":"PTHLH","Gene synonym":["HHM","PLP","PTHR","PTHRP"],"Ensembl":"ENSG00000087494","Gene description":"Parathyroid hormone like hormone","Uniprot":["P12272"],"Chromosome":"12","Position":"27958084-27972733","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"21.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"155.1","Breast lactating cells":"423.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Luminal cells":"155.1","Secretory cells":"423.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"20.1","CGE interneuron":"45.9","LAMP5-LHX6 and Chandelier":"49.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"267.6","Lung Squamous Cell Carcinoma (TCGA)":"231.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"243.3"},"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Skeletal muscle - Fibroblasts","Skin - Outer root sheath cells","Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035982"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":"Secreted in other tissues","Secretome function":"Hormone","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 4: Breast lactating luminal cells - Lactation","Interactions":5,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA035982":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.52e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.92e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.19e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"}},{"Gene":"PTPMT1","Gene synonym":["DUSP23","MOSP","PLIP"],"Ensembl":"ENSG00000110536","Gene description":"Protein tyrosine phosphatase mitochondrial 1","Uniprot":["Q8WUK0"],"Chromosome":"11","Position":"47565430-47573461","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"170.9","Late primary spermatocytes":"269.0","Late spermatids":"849.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"849.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"7445992.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"850003.8","fallopian tube":"963751.7"},"Antibody":["HPA043932","HPA060060"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":31,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA043932":null,"HPA060060":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.42e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.91e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"}},{"Gene":"PTPN20","Gene synonym":["bA142I17.1","bA42B19.1","CT126","DKFZP566K0524","PTPN20A","PTPN20B"],"Ensembl":"ENSG00000204179","Gene description":"Protein tyrosine phosphatase non-receptor type 20","Uniprot":["Q4JDL3"],"Chromosome":"10","Position":"46911396-47002488","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"12.7","tongue":"13.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"48.9","Distal convoluted tubule cells":"61.9","Early spermatids":"71.8","Gonadotrophs":"54.6","Proximal tubule cells":"83.3","Renal collecting duct intercalated cells":"48.0","Renal collecting duct principal cells":"37.6","Renal connecting tubule cells":"51.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"51.7","Myocytes":"48.9","Pituitary endocrine cells":"54.6","Renal nephron cells":"83.3","Spermatogenic cell types":"71.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"131.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"1.6"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4168","Protein cell type specific Intensity":{"Collecting ducts":"416826.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043337","HPA046896","HPA048310","HPA069148"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centriolar satellite"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":1,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":null,"Antibody RRID":{"HPA043337":null,"HPA046896":null,"HPA048310":null,"HPA069148":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PTPRQ","Gene synonym":["DFNB84"],"Ensembl":"ENSG00000139304","Gene description":"Protein tyrosine phosphatase receptor type Q","Uniprot":[],"Chromosome":"12","Position":"80402178-80680273","Protein class":["Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"7.8","urinary bladder":"4.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Podocytes":"9487.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Renal nephron cells":"9487.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"eccentric medium spiny neuron":"99.9","ependymal cell":"262.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"6.5"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Kidney - Podocytes","Lung - Alveolar cells type 1","Skin - Sebaceous gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":null,"Protein cell type distribution":null,"Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":null,"Protein tissue distribution":null,"Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053245"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 57: Podocytes - Glomerular filtration","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA053245":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.09e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PTPRT","Gene synonym":["KIAA0283","RPTPrho"],"Ensembl":"ENSG00000196090","Gene description":"Protein tyrosine phosphatase receptor type T","Uniprot":["O14522"],"Chromosome":"20","Position":"42072752-43189970","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protein phosphatase","Receptor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.8","fallopian tube":"10.2","lymphoid tissue":"5.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"594.5","Oligodendrocyte progenitor cells":"826.3","Pancreatic acinar cells":"535.6","Pancreatic islet cells":"366.7","Pituicytes\/FSCs":"3596.7","Respiratory ciliated cells":"1599.0","Retinal bipolar cells":"495.2","Salivary myoepithelial cells":"653.2","Tuft cells":"991.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1599.0","Glial cells":"3596.7","Secretory gland support":"991.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"2036.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"9.3","Prostate Adenocarcinoma (TCGA)":"3.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"1.0","Sarcoma":"2.3"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB069423":null,"HPA017336":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"}},{"Gene":"PTRH1","Gene synonym":["C9orf115","PTH1"],"Ensembl":"ENSG00000187024","Gene description":"Peptidyl-tRNA hydrolase 1 homolog","Uniprot":["Q86Y79"],"Chromosome":"9","Position":"127690348-127724873","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","RNA-binding","tRNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"127.8","Epicardial cells":"113.7","Epididymal efferent duct absorptive cells":"106.1","Peritubular myoid cells":"83.7","Respiratory ciliated cells":"100.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"127.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"81.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021223":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.48e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"}},{"Gene":"PTRHD1","Gene synonym":["C2orf79","LOC391356"],"Ensembl":"ENSG00000184924","Gene description":"Peptidyl-tRNA hydrolase domain containing 1","Uniprot":["Q6GMV3"],"Chromosome":"2","Position":"24789728-24793391","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Intellectual disability","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"238.7","Esophageal apical cells":"245.9","Esophageal suprabasal cells":"266.5","Late primary spermatocytes":"332.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"31738794.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019951"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"60000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA019951":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.05e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"}},{"Gene":"PTTG1","Gene synonym":["EAP1","ECRAR","HPTTG","PTTG","securin","TUTR1"],"Ensembl":"ENSG00000164611","Gene description":"PTTG1 regulator of sister chromatid separation, securin","Uniprot":["O95997"],"Chromosome":"5","Position":"160421855-160428739","Protein class":["Cancer-related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Chromosome partition","DNA damage","DNA repair","Mitosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"150.9","lymphoid tissue":"135.4","testis":"163.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"253.1","Early spermatids":"622.6","Enteric transient amplifying cells":"201.8","Esophageal basal cells":"520.4","Extravillous trophoblasts":"201.3","Gastric progenitor cells":"307.6","Late primary spermatocytes":"1846.1","Oocytes":"336.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"520.4","Spermatogenic cell types":"1846.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"miscellaneous":"14.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"218.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"T-cells":"218.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB008373","HPA008890","HPA045034"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":21,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"CAB008373":null,"HPA008890":null,"HPA045034":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.85e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.55e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-3"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Enteric glia cells","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"6936568.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"94313","Protein tissue specific Intensity":{"cerebral cortex":"9431330.8"},"Antibody":["HPA047746"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Plasma membrane","Cytokinetic bridge","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":64,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Plasma membrane","Cytokinetic bridge","Centrosome","Basal body"],"Antibody RRID":{"HPA047746":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PWWP3A","Gene synonym":["EXPAND1","MUM-1","MUM1"],"Ensembl":"ENSG00000160953","Gene description":"PWWP domain containing 3A, DNA repair factor","Uniprot":["Q2TAK8"],"Chromosome":"19","Position":"1354711-1378431","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"228.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":1,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA048063":null,"HPA054491":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"}},{"Gene":"PXDNL","Gene synonym":["FLJ25471","PMR1"],"Ensembl":"ENSG00000147485","Gene description":"Peroxidasin like","Uniprot":["A1KZ92"],"Chromosome":"8","Position":"51319577-51809445","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Endonuclease","Hydrolase","Nuclease","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"heart muscle":"43.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"902.6","Fibro-adipogenic progenitors":"179.2","Late primary spermatocytes":"134.9","M\u00fcller glia":"231.9","Myonuclei":"127.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Fibro-adipogenic progenitors":"179.2","Glial cells":"231.9","Myocytes":"902.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA007919":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.92e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"PXYLP1","Gene synonym":["ACPL2","FLJ23751"],"Ensembl":"ENSG00000155893","Gene description":"2-phosphoxylose phosphatase 1","Uniprot":["Q8TE99"],"Chromosome":"3","Position":"141228726-141367753","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"139.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"176.6","Epididymal principal cells":"275.5","Late primary spermatocytes":"288.2","Late spermatids":"165.0","Renal collecting duct principal cells":"118.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"275.5","Spermatogenic cell types":"288.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"43040.3","Pancreas epithelial cells":"161556.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"54","Protein tissue specific Intensity":{"intestine":"5432.0"},"Antibody":["HPA017243"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA017243":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"}},{"Gene":"PYROXD1","Gene synonym":["DKFZp762G094","FLJ22028"],"Ensembl":"ENSG00000121350","Gene description":"Pyridine nucleotide-disulphide oxidoreductase domain 1","Uniprot":["Q8WU10"],"Chromosome":"12","Position":"21437615-21471250","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Limb-girdle muscular dystrophy","Myofibrillar myopathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"269300.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4003","Protein tissue specific Intensity":{"Stomach":"400277.5"},"Antibody":["HPA038319","HPA038320"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":1,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA038319":null,"HPA038320":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"PZP","Gene synonym":["CPAMD6"],"Ensembl":"ENSG00000126838","Gene description":"PZP alpha-2-macroglobulin like","Uniprot":["P20742"],"Chromosome":"12","Position":"9148840-9208395","Protein class":["Cancer-related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Serine protease inhibitor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"35","RNA tissue specific nTPM":{"liver":"76.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"199.7","Ependymal cells":"196.9","Hepatocytes":"71.2","Mast cells":"268.4","Myonuclei":"74.7","NK-cells":"55.8","Respiratory ciliated cells":"153.5","T-cells":"71.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"196.9","Mast cells":"268.4","Myocytes":"199.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"171.8","leukocyte":"66.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"1.3","Uterine Corpus Endometrial Carcinoma (TCGA)":"1.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"1.1","MAIT T-cell":"1.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"T-cells":"1.1"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"cervical cancer":"1.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"975211.9","Collecting ducts":"556937.7","Distal tubules":"605732.2","Glomeruli":"622634.8","Hepatocytes":"1459975.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"6320874.2"},"Antibody":["HPA041403","HPA041471"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Enzyme inhibitor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"34000000000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041403":null,"HPA041471":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-1"}},{"Gene":"QPCTL","Gene synonym":["FLJ20084"],"Ensembl":"ENSG00000011478","Gene description":"Glutaminyl-peptide cyclotransferase like","Uniprot":["Q9NXS2"],"Chromosome":"19","Position":"45692403-45703989","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Plasma cells":"33.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"4620080.3","B-cells":"3879997.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"4790925.2"},"Antibody":["HPA040797"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA040797":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"QRICH2","Gene synonym":["DKFZP434P0316"],"Ensembl":"ENSG00000129646","Gene description":"Glutamine rich 2","Uniprot":["Q9H0J4"],"Chromosome":"17","Position":"76274049-76308276","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"21.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"52.9","Late primary spermatocytes":"27.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"52.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"102","Protein tissue specific Intensity":{"pancreas":"10226.4"},"Antibody":["HPA052219"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Nuclear membrane","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA052219":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"QRSL1","Gene synonym":["DKFZP564C1278","FLJ10989","FLJ12189","FLJ13447","GatA"],"Ensembl":"ENSG00000130348","Gene description":"Glutaminyl-tRNA amidotransferase subunit QRSL1","Uniprot":["Q9H0R6"],"Chromosome":"6","Position":"106629578-106668417","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Ligase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"95.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"memory B-cell":"86.6","naive B-cell":"71.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"B-cells":"86.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":52,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA029585":null,"HPA029587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023073","HPA023153"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023073":null,"HPA023153":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.74e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.43e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"}},{"Gene":"R3HCC1L","Gene synonym":["C10orf28","GIDRP86","PSORT"],"Ensembl":"ENSG00000166024","Gene description":"R3H domain and coiled-coil containing 1 like","Uniprot":["Q7Z5L2"],"Chromosome":"10","Position":"98134624-98244897","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"214269.4","T-cells":"273677.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"10983","Protein tissue specific Intensity":{"bone marrow":"1538878.0","intestine":"971205.1","lymphoid tissue":"784780.5"},"Antibody":["HPA037367"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":2,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA037367":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.72e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"}},{"Gene":"RAB11A","Gene synonym":["YL8"],"Ensembl":"ENSG00000103769","Gene description":"RAB11A, member RAS oncogene family","Uniprot":["P62491"],"Chromosome":"15","Position":"65726054-65891989","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"2205.9","Esophageal apical cells":"4604.1","Platelets":"1542.8","Syncytiotrophoblasts":"1451.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"4604.1","Barrier epithelial cells":"2205.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"539111.7","intestine":"588492.2"},"Antibody":["CAB013097","HPA051697","HPA060686"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Primary cilium","Centriolar satellite","Basal body","Cytosol","Equatorial segment","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":297,"Subcellular main location":["Vesicles","Centriolar satellite"],"Subcellular additional location":["Primary cilium","Basal body","Cytosol","Equatorial segment","Mid piece","Principal piece"],"Antibody RRID":{"CAB013097":null,"HPA051697":null,"HPA060686":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.19e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"}},{"Gene":"RAB11FIP5","Gene synonym":["GAF1","KIAA0857","pp75","RIP11"],"Ensembl":"ENSG00000135631","Gene description":"RAB11 family interacting protein 5","Uniprot":["Q9BXF6"],"Chromosome":"2","Position":"73073382-73156721","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"35.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"39.5","Proximal tubule cells":"33.6","Renal connecting tubule cells":"48.6","Retinal ganglion cells":"57.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"48.6","Neuronal cells":"57.9","Renal nephron cells":"39.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"14148183.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"18943998.7"},"Antibody":["HPA036406","HPA036407"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Primary cilium","Centriolar satellite","Basal body","Acrosome","Principal piece","End piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 27: T-cells - Unknown function","Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":28,"Subcellular main location":["Vesicles","Centriolar satellite","Basal body"],"Subcellular additional location":["Primary cilium","Acrosome","Principal piece","End piece","Annulus"],"Antibody RRID":{"HPA036406":null,"HPA036407":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.35e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.54e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.00e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.55e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.55e-4"}},{"Gene":"RAB1A","Gene synonym":["RAB1","YPT1"],"Ensembl":"ENSG00000138069","Gene description":"RAB1A, member RAS oncogene family","Uniprot":["P62820"],"Chromosome":"2","Position":"65070696-65130331","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Autophagy","ER-Golgi transport","Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1046.6","Late spermatids":"1610.3","Neutrophils":"2120.8","Syncytiotrophoblasts":"1104.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2120.8","Spermatogenic cell types":"1610.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB005331","HPA056141"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7200000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":107,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB005331":null,"HPA056141":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.73e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.29e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.61e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"}},{"Gene":"RAB27B","Gene synonym":[],"Ensembl":"ENSG00000041353","Gene description":"RAB27B, member RAS oncogene family","Uniprot":["O00194"],"Chromosome":"18","Position":"54717860-54895516","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"stomach 1":"41.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"274.6","Esophageal apical cells":"306.4","Foveolar cells":"566.9","Late spermatids":"295.3","Mast cells":"618.3","Megakaryocyte progenitors":"377.4","Megakaryocytes":"933.4","Platelets":"1213.7","Prostatic glandular cells":"289.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"566.9","Mast cells":"618.3","Megakaryocytes":"933.4","Platelets":"1213.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"2.2","NK-cell":"2.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Mast cells","Adrenal gland - Adrenal medulla cells","Lung - Alveolar cells type 2","Pituitary gland - Thyrotropes","Prostate - Prostate glandular cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"9436010.9","Large ducts":"11001465.3","Microglia and Neuropil":"9467602.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"19108964.0","salivary gland":"18699932.3"},"Antibody":["CAB017712","HPA019849"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8900000","Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":23,"Subcellular main location":["Golgi apparatus","Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB017712":null,"HPA019849":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.26e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.49e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.61e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"}},{"Gene":"RAB28","Gene synonym":[],"Ensembl":"ENSG00000157869","Gene description":"RAB28, member RAS oncogene family","Uniprot":["P51157"],"Chromosome":"4","Position":"13361354-13484365","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Cone-rod dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Somatotrophs":"333.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Fibroblasts","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"684425.9"},"Antibody":["HPA044575"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044575":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.87e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"}},{"Gene":"RAB32","Gene synonym":[],"Ensembl":"ENSG00000118508","Gene description":"RAB32, member RAS oncogene family","Uniprot":["Q13637"],"Chromosome":"6","Position":"146543833-146554953","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant","Parkinson disease","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"165.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hofbauer cells":"404.9","Kupffer cells":"558.6","Late spermatids":"241.8","Megakaryocytes":"463.6","Melanocytes":"306.6","Neutrophils":"228.3","Platelets":"1558.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"463.6","Mononuclear phagocytes":"558.6","Platelets":"1558.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"77.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"86.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"42","RNA blood lineage specific nTPM":{"dendritic cells":"42.5","granulocytes":"86.6","monocytes":"46.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"34101026.3","Neutrophils":"21336671.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"34597773.4","lymphoid tissue":"14944520.1"},"Antibody":["HPA025731"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA025731":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.07e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.81e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.81e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"}},{"Gene":"RAB36","Gene synonym":[],"Ensembl":"ENSG00000100228","Gene description":"RAB36, member RAS oncogene family","Uniprot":["O95755"],"Chromosome":"22","Position":"23145366-23165663","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"25.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"61.0","Ependymal cells":"33.4","Epididymal efferent duct ciliated cells":"46.2","Fallopian tube ciliated cells":"80.2","Late spermatids":"38.6","Respiratory ciliated cells":"141.6","Respiratory deuterosomal cells":"49.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"141.6","Spermatogenic cell types":"38.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"18.5","ependymal cell":"41.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"neutrophil":"11.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"11.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"20.9"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"722401.6","Neurons":"240849.1","Pancreatic islets":"580731.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"65","Protein tissue specific Intensity":{"fallopian tube":"6546.0"},"Antibody":["HPA059631"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA059631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.59e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.78e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"}},{"Gene":"RAB37","Gene synonym":[],"Ensembl":"ENSG00000172794","Gene description":"RAB37, member RAS oncogene family","Uniprot":["Q96AX2"],"Chromosome":"17","Position":"74670578-74747335","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"23.1","brain":"36.8","lymphoid tissue":"19.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"88.1","Hematopoietic stem cells":"92.2","Mast cells":"79.1","Megakaryocyte progenitors":"54.8","Megakaryocyte-Erythroid progenitors":"65.5","Megakaryocytes":"136.0","Platelets":"435.0","Retinal amacrine cells":"154.6","Retinal ganglion cells":"146.8","Thymocytes":"77.9","Tuft cells":"103.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"136.0","Neuronal cells":"154.6","Platelets":"435.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"234.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"269.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"269.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"42.8","Myeloma":"22.4"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RAB3IL1","Gene synonym":["GRAB"],"Ensembl":"ENSG00000167994","Gene description":"RAB3A interacting protein like 1","Uniprot":["Q8TBN0"],"Chromosome":"11","Position":"61897301-61920269","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"126.6","Hofbauer cells":"146.1","Kupffer cells":"51.2","Late spermatids":"191.2","Leydig cells":"57.2","Lymphatic endothelial cells":"28.4","Peritubular myoid cells":"46.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Leydig cells":"57.2","Mononuclear phagocytes":"146.1","Spermatogenic cell types":"191.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"19.2","fibroblast":"32.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Heart muscle - Fibroblasts","Lung - Fibroblasts_2","Prostate - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"9298533.6","Proximal tubules":"7001949.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"5568592.1"},"Antibody":["HPA039723"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":36,"Subcellular main location":["Centriolar satellite","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039723":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.79e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.46e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.68e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.73e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.55e-5"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"}},{"Gene":"RAB3IP","Gene synonym":["FLJ22548","RABIN3","RABIN8"],"Ensembl":"ENSG00000127328","Gene description":"RAB3A interacting protein","Uniprot":["Q96QF0"],"Chromosome":"12","Position":"69738860-69823204","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"109.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"315.6","Early spermatids":"219.1","Late spermatids":"475.1","Retinal pigment epithelial cells":"230.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"315.6","Spermatogenic cell types":"475.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"250.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"16384","Protein tissue specific Intensity":{"cerebral cortex":"809029.5","fallopian tube":"2467767.2"},"Antibody":["HPA039794","HPA057728"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":38,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"HPA039794":null,"HPA057728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.43e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.06e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"}},{"Gene":"RAB4A","Gene synonym":["HRES-1\/RAB4","RAB4"],"Ensembl":"ENSG00000168118","Gene description":"RAB4A, member RAS oncogene family","Uniprot":["P20338"],"Chromosome":"1","Position":"229271062-229305894","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric chief cells":"342.9","Parietal cells":"592.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"592.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"32.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"32.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1900000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":126,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.49e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"}},{"Gene":"RAB5IF","Gene synonym":["C20orf24","PNAS-11","RCAF1","RIP5"],"Ensembl":"ENSG00000101084","Gene description":"RAB5 interacting factor","Uniprot":["Q9BUV8"],"Chromosome":"20","Position":"36605779-36612557","Protein class":["Disease related genes","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"222.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Esophageal apical cells":"2431.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2431.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Neutrophils_2","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA057387","HPA076106"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":10,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA057387":null,"HPA076106":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.32e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.17e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.41e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - 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Fibroblasts","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"23009243.6"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5200000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.95e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-3"}},{"Gene":"RABEPK","Gene synonym":["bA65N13.1","RAB9P40"],"Ensembl":"ENSG00000136933","Gene description":"Rab9 effector protein with kelch motifs","Uniprot":["Q7Z6M1"],"Chromosome":"9","Position":"125200542-125234161","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatocytes":"109.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"434566.8","Keratinocytes":"336626.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"483444.1"},"Antibody":["HPA023920","HPA024415"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA023920":null,"HPA024415":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"}},{"Gene":"RABGAP1L","Gene synonym":["FLJ38519","HHL","KIAA0471","TBC1D18"],"Ensembl":"ENSG00000152061","Gene description":"RAB GTPase activating protein 1 like","Uniprot":["B7ZAP0","Q5R372"],"Chromosome":"1","Position":"174159410-174995308","Protein class":["Disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Endocytosis","Protein transport","Transport"],"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"114.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"1614.3","Choroid plexus epithelial cells":"1940.8","pDCs":"2128.2","Podocytes":"1591.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"94.0"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"10284951.5"},"Antibody":["HPA054695"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 6: Plasmacytoid dendritic cells - Viral sensing & interferon response","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054695":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"}},{"Gene":"RABGEF1","Gene synonym":["rabex-5","RABEX5"],"Ensembl":"ENSG00000154710","Gene description":"RAB guanine nucleotide exchange factor 1","Uniprot":["Q9UJ41"],"Chromosome":"7","Position":"66682164-66811464","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Endocytosis","Protein transport","Transport","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"72.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Astrocytes":"188.8","Bergmann glia":"177.2","Brain excitatory neurons":"195.5","Brain inhibitory neurons":"208.7","Choroid plexus epithelial cells":"294.5","Ependymal cells":"158.0","Microglia":"146.2","Oligodendrocyte progenitor cells":"170.5","Oligodendrocytes":"328.0","Other brain neurons":"228.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"294.5","Glial cells":"328.0","Neuronal cells":"228.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":39,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA001407":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.86e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.25e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.48e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.58e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"}},{"Gene":"RABIF","Gene synonym":["mss4","RASGRF3"],"Ensembl":"ENSG00000183155","Gene description":"RAB interacting factor","Uniprot":["P47224"],"Chromosome":"1","Position":"202878282-202889149","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Late spermatids":"5434.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5434.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027715","HPA054936"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":44,"Subcellular main location":["Microtubules","Cytokinetic bridge"],"Subcellular additional location":null,"Antibody RRID":{"HPA027715":null,"HPA054936":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.60e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"}},{"Gene":"RABL2A","Gene synonym":[],"Ensembl":"ENSG00000144134","Gene description":"RAB, member of RAS oncogene family like 2A","Uniprot":["Q9UBK7"],"Chromosome":"2","Position":"113627229-113643396","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"20.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"124.7","Endometrial ciliated cells":"88.1","Ependymal cells":"222.8","Epididymal efferent duct ciliated cells":"91.5","Epididymal principal cells":"75.0","Fallopian tube ciliated cells":"159.4","Respiratory ciliated cells":"207.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"222.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"247.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042642","HPA042700","HPA044007"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA042642":null,"HPA042700":null,"HPA044007":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.49e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.34e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"}},{"Gene":"RACGAP1","Gene synonym":["CYK4","MgcRacGAP"],"Ensembl":"ENSG00000161800","Gene description":"Rac GTPase activating protein 1","Uniprot":["Q9H0H5"],"Chromosome":"12","Position":"49976923-50033136","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","Ion transport","Spermatogenesis","Transport"],"Molecular function":["Developmental protein","GTPase activation"],"Disease involvement":["Congenital dyserythropoietic anemia","Disease variant","Hereditary hemolytic anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"36.7","lymphoid tissue":"40.0","testis":"42.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"89.8","Erythrocyte progenitors":"76.0","Extravillous trophoblasts":"63.2","Gastric progenitor cells":"51.3","Late primary spermatocytes":"53.4","Monocyte progenitors":"105.7","Neutrophil progenitors":"66.2","Renal collecting duct intercalated cells":"49.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"76.0","Mononuclear phagocytes":"105.7","Spermatogenic cell types":"89.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"44.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4705","Protein cell type specific Intensity":{"Granulosa cells":"470527.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"26974","Protein tissue specific Intensity":{"bone marrow":"2697393.5"},"Antibody":["CAB025859","HPA039427","HPA043912"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":56,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB025859":null,"HPA039427":null,"HPA043912":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.95e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.71e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.74e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.27e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.07e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.33e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.07e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"}},{"Gene":"RAD17","Gene synonym":["CCYC","RAD17Sp","Rad24"],"Ensembl":"ENSG00000152942","Gene description":"RAD17 checkpoint clamp loader component","Uniprot":["O75943"],"Chromosome":"5","Position":"69369293-69414801","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","DNA damage"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"44.7","Early primary spermatocytes":"56.6","Early spermatids":"41.9","Late primary spermatocytes":"52.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"44.7","Spermatogenic cell types":"56.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"1394823.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"5520","Protein tissue specific Intensity":{"cerebral cortex":"610426.7","fallopian tube":"251694.0","intestine":"603186.7","lymphoid tissue":"742726.1"},"Antibody":["CAB004551","HPA005448"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB004551":null,"HPA005448":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.07e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"RAD21L1","Gene synonym":["dJ545L17.2","RAD21L"],"Ensembl":"ENSG00000244588","Gene description":"RAD21 cohesin complex component like 1","Uniprot":["Q9H4I0"],"Chromosome":"20","Position":"1226044-1296421","Protein class":["Predicted intracellular proteins"],"Biological process":["Chromosome partition","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"10.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"14","RNA single cell type specific nCPM":{"Early primary spermatocytes":"103.6","Early spermatids":"183.9","Late primary spermatocytes":"58.9","Late spermatids":"201.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"21","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"201.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"1.2"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"30","Protein tissue specific Intensity":{"salivary gland":"3000.8"},"Antibody":["HPA053282"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053282":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RAD23B","Gene synonym":["HHR23B","HR23B","P58"],"Ensembl":"ENSG00000119318","Gene description":"RAD23 homolog B, nucleotide excision repair protein","Uniprot":["P54727"],"Chromosome":"9","Position":"107283137-107332192","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"2069.5","Neutrophils":"668.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2069.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4800000","Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":72,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB033868":null,"HPA029718":null,"HPA029720":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.58e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"}},{"Gene":"RAD51","Gene synonym":["BRCC5","FANCR","HsRad51","HsT16930","RAD51A","RECA"],"Ensembl":"ENSG00000051180","Gene description":"RAD51 recombinase","Uniprot":["Q06609"],"Chromosome":"15","Position":"40694774-40732340","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","Fanconi anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"14.6","testis":"22.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"43.3","Differentiating spermatogonia":"31.0","Early primary spermatocytes":"54.4","Epicardial cells":"52.3","Erythrocyte progenitors":"40.7","Extravillous trophoblasts":"89.0","Late primary spermatocytes":"57.4","Megakaryocyte progenitors":"31.5","Migrating cytotrophoblasts":"61.4","Monocyte progenitors":"37.0","Oocytes":"82.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"52.3","Oocytes":"82.9","Spermatogenic cell types":"57.4","Trophoblast cells":"89.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"47.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"508","Protein cell type specific Intensity":{"Granulosa cells":"49194.3","Oocytes":"52446.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB010381","HPA039310"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":107,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Mitochondria","Cytosol"],"Antibody RRID":{"CAB010381":null,"HPA039310":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.19e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.79e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.47e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.09e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.03e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.33e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.22e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.27e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"RAD51AP1","Gene synonym":["PIR51"],"Ensembl":"ENSG00000111247","Gene description":"RAD51 associated protein 1","Uniprot":["Q96B01"],"Chromosome":"12","Position":"4538798-4560047","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Meiosis"],"Molecular function":["DNA-binding","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"15.9","lymphoid tissue":"13.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"41.4","Early primary spermatocytes":"56.0","Early spermatids":"58.5","Enteric transient amplifying cells":"41.9","Erythrocyte progenitors":"78.8","Extravillous trophoblasts":"41.3","Hofbauer cells":"65.0","Late spermatids":"121.3","Megakaryocyte progenitors":"50.8","Migrating cytotrophoblasts":"36.4","Monocyte progenitors":"65.3","Neutrophil progenitors":"36.5","Oocytes":"69.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"78.8","Mononuclear phagocytes":"65.3","Oocytes":"69.1","Spermatogenic cell types":"121.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"7.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"20868","Protein cell type specific Intensity":{"Granulosa cells":"2086827.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051499"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA051499":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.98e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.31e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.36e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.94e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.46e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.26e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"}},{"Gene":"RAD51C","Gene synonym":["FANCO","RAD51L2"],"Ensembl":"ENSG00000108384","Gene description":"RAD51 paralog C","Uniprot":["O43502"],"Chromosome":"17","Position":"58692573-58735611","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Fanconi anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"164.8","Extravillous trophoblasts":"128.9","Late primary spermatocytes":"149.5","Oocytes":"216.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"216.4","Spermatogenic cell types":"164.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 6: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":33,"Subcellular main location":["Nucleoplasm","Mitochondria","Cytosol"],"Subcellular additional location":["Vesicles","Cell Junctions"],"Antibody RRID":{"HPA045198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.22e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.02e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"}},{"Gene":"RADIL","Gene synonym":["FLJ10324","KIAA1849","RASIP2"],"Ensembl":"ENSG00000157927","Gene description":"Rap associating with DIL domain","Uniprot":["Q96JH8"],"Chromosome":"7","Position":"4797055-4883716","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"42.5","Breast lactating cells":"80.1","Differentiating spermatogonia":"42.6","Ependymal cells":"53.5","Fibro-adipogenic progenitors":"54.1","Late primary spermatocytes":"45.6","Lymphatic endothelial cells":"63.8","Retinal amacrine cells":"69.4","Thyrotrophs":"34.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Endothelial cells":"63.8","Neuronal cells":"69.4","Secretory cells":"80.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"90.4","pericyte":"70.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"3.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"13.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":13,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA051776":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RAE1","Gene synonym":["Gle2","Mnrp41"],"Ensembl":"ENSG00000101146","Gene description":"Ribonucleic acid export 1","Uniprot":["P78406"],"Chromosome":"20","Position":"57351223-57379211","Protein class":["Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Cell cycle","Cell division","Host-virus interaction","Mitosis","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"96.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"117.6","Late primary spermatocytes":"384.8","Oocytes":"386.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"386.8","Spermatogenic cell types":"384.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":55,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA048795":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.13e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"}},{"Gene":"RAG2","Gene synonym":[],"Ensembl":"ENSG00000175097","Gene description":"Recombination activating 2","Uniprot":["P55895"],"Chromosome":"11","Position":"36575574-36598279","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA recombination"],"Molecular function":["Chromatin regulator"],"Disease involvement":["Disease variant","SCID"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"lymphoid tissue":"139.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"9.0","Cardiomyocytes":"27.0","Choroid plexus epithelial cells":"4.0","Epicardial cells":"4.5","Fibro-adipogenic progenitors":"2.6","Late primary spermatocytes":"4.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"9.0","Myocytes":"27.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"4.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"23","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"2.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"56","RNA cell line specific nTPM":{"Leukemia":"14.1","lymphoma":"10.5"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA065704":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RAI14","Gene synonym":["DKFZp564G013","KIAA1334","NORPEG","RAI13"],"Ensembl":"ENSG00000039560","Gene description":"Retinoic acid induced 14","Uniprot":["Q9P0K7"],"Chromosome":"5","Position":"34656328-34832612","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"356.7","Conjunctival goblet cells":"415.5","Early spermatids":"392.3","Late spermatids":"575.4","Salivary duct cells":"419.0","Syncytiotrophoblasts":"571.7","Urothelial cells":"329.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"575.4","Trophoblast cells":"571.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"191.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":53,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Actin filaments","Cytosol"],"Antibody RRID":{"HPA036949":null,"HPA036950":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.36e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.34e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"}},{"Gene":"RALGPS1","Gene synonym":["KIAA0351","RALGEF2","RALGPS1A"],"Ensembl":"ENSG00000136828","Gene description":"Ral GEF with PH domain and SH3 binding motif 1","Uniprot":["Q5JS13"],"Chromosome":"9","Position":"126914774-127223166","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gonadotrophs":"319.9","Rod photoreceptor cells":"322.4","Thyrotrophs":"346.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"2.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"335862.9","Microglia and Neuropil":"270814.6","Neurons":"234754.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"23322.2"},"Antibody":["HPA014749"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014749":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.66e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"}},{"Gene":"RALGPS2","Gene synonym":["FLJ10244","FLJ25604","KIAA0351"],"Ensembl":"ENSG00000116191","Gene description":"Ral GEF with PH domain and SH3 binding motif 2","Uniprot":["Q86X27"],"Chromosome":"1","Position":"178725165-178921842","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":["Alzheimer disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"48.9","retina":"49.8","testis":"67.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"1377.7","Rod photoreceptor cells":"824.1","Urothelial cells":"632.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"1377.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"memory B-cell":"29.0","naive B-cell":"23.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"B-cells":"29.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Enteric glia cells","Liver - Hepatocytes","Spleen - B-cells (Spleen)","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"3485546.6","Neurons":"4646073.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"3720957.8","intestine":"8584351.3","lymphoid tissue":"13751947.7"},"Antibody":["HPA027143","HPA028328"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":23,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA027143":null,"HPA028328":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.29e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"}},{"Gene":"RANBP1","Gene synonym":["HTF9A"],"Ensembl":"ENSG00000099901","Gene description":"RAN binding protein 1","Uniprot":["P43487"],"Chromosome":"22","Position":"20115938-20127355","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"594.9","Esophageal basal cells":"629.8","Extravillous trophoblasts":"813.8","Gastric progenitor cells":"505.0","Late primary spermatocytes":"775.7","Migrating cytotrophoblasts":"719.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"775.7","Trophoblast cells":"813.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA065868","HPA065931"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2400000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":59,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA065868":null,"HPA065931":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.24e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.86e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"}},{"Gene":"RANBP17","Gene synonym":[],"Ensembl":"ENSG00000204764","Gene description":"RAN binding protein 17","Uniprot":["Q9H2T7"],"Chromosome":"5","Position":"170861870-171300015","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"342.8","Alveolar cells type 1":"545.4","Choroid plexus epithelial cells":"468.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"545.4","Ciliated cells":"468.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"611.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"40826.2","Oocytes":"136286.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029568","HPA029569"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":1,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Nuclear membrane","Cytosol"],"Antibody RRID":{"HPA029568":null,"HPA029569":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RANBP3","Gene synonym":[],"Ensembl":"ENSG00000031823","Gene description":"RAN binding protein 3","Uniprot":["Q9H6Z4"],"Chromosome":"19","Position":"5916139-5978142","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"146.1","Late spermatids":"109.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"146.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Pancreas - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043375","HPA043389"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"25000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043375":null,"HPA043389":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"}},{"Gene":"RANBP9","Gene synonym":["RanBPM"],"Ensembl":"ENSG00000010017","Gene description":"RAN binding protein 9","Uniprot":["Q96S59"],"Chromosome":"6","Position":"13621498-13711835","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1328.5","Neutrophil progenitors":"470.7","Neutrophils":"488.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1328.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"4144772.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"13624630.7"},"Antibody":["HPA023427","CAB033767","HPA050007","HPA076784"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":128,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"CAB033767":null,"HPA023427":null,"HPA050007":null,"HPA076784":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.75e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.31e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"}},{"Gene":"RAP1GDS1","Gene synonym":["SmgGDS"],"Ensembl":"ENSG00000138698","Gene description":"Rap1 GTPase-GDP dissociation stimulator 1","Uniprot":["P52306"],"Chromosome":"4","Position":"98261384-98443858","Protein class":["Cancer-related genes","Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":["Cancer-related genes","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"480.3","Rod photoreceptor cells":"503.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"138777896.7","Microglia and Neuropil":"141795516.9","Neurons":"98141118.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"202567179.0"},"Antibody":["HPA019060","HPA048820"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"92000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":33,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019060":null,"HPA048820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.91e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"}},{"Gene":"RAPGEF6","Gene synonym":["PDZ-GEF2","PDZGEF2","RA-GEF-2"],"Ensembl":"ENSG00000158987","Gene description":"Rap guanine nucleotide exchange factor 6","Uniprot":["Q8TEU7"],"Chromosome":"5","Position":"131423921-131635231","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"114.2","Bergmann glia":"146.5","Brain excitatory neurons":"297.3","Brain inhibitory neurons":"270.6","Choroid plexus epithelial cells":"169.2","Ependymal cells":"123.7","Microglia":"527.9","Oligodendrocyte progenitor cells":"198.1","Oligodendrocytes":"483.9","Other brain neurons":"215.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Ciliated cells":"169.2","Glial cells":"527.9","Neuronal cells":"297.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":18,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA037982":null,"HPA037983":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"}},{"Gene":"RARS2","Gene synonym":["DALRD2","dJ382I10.6","MGC14993","MGC23778","PRO1992","RARSL"],"Ensembl":"ENSG00000146282","Gene description":"Arginyl-tRNA synthetase 2, mitochondrial","Uniprot":["Q5T160"],"Chromosome":"6","Position":"87513459-87590028","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase"],"Disease involvement":["Disease variant","Neurodegeneration","Pontocerebellar hypoplasia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"3677537.1"},"Antibody":["HPA039987","HPA042645"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":20,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA039987":null,"HPA042645":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.84e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - 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Adrenal medulla cells","Colon - Enteric glia cells","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028242"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA028242":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RASSF8","Gene synonym":["C12orf2","HoJ-1"],"Ensembl":"ENSG00000123094","Gene description":"Ras association domain family member 8","Uniprot":["Q8NHQ8"],"Chromosome":"12","Position":"25958232-26079892","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"55.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"660.7","Epicardial cells":"893.7","Late spermatids":"1047.8","Microglia":"620.7","Podocytes":"604.0","Retinal horizontal cells":"1322.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"893.7","Neuronal cells":"1322.2","Spermatogenic cell types":"1047.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"706.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"1.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":26,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038163":null,"HPA038164":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.14e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"}},{"Gene":"RBBP6","Gene synonym":["P2P-R","PACT","SNAMA"],"Ensembl":"ENSG00000122257","Gene description":"RB binding protein 6, ubiquitin ligase","Uniprot":["Q7Z6E9"],"Chromosome":"16","Position":"24537693-24572863","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA replication","Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"135.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Platelets":"1001.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"1001.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":37,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"CAB032866":null,"HPA041725":null,"HPA043544":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.87e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"}},{"Gene":"RBFOX1","Gene synonym":["A2BP1","FOX-1","HRNBP1"],"Ensembl":"ENSG00000078328","Gene description":"RNA binding fox-1 homolog 1","Uniprot":["Q9NWB1"],"Chromosome":"16","Position":"5239802-7713340","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"65.9","skeletal muscle":"80.8","tongue":"41.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"6364.6","Brain inhibitory neurons":"6575.7","Epicardial cells":"1423.6","Lactotrophs":"1931.7","Myonuclei":"2310.7","Neutrophil progenitors":"1675.6","Oligodendrocyte progenitor cells":"1432.4","Other brain neurons":"2689.9","Podocytes":"3330.3","Retinal amacrine cells":"2565.0","Retinal ganglion cells":"3692.8","Thymic myoid cells":"1877.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"2310.7","Neuronal cells":"6575.7","Pituitary endocrine cells":"1931.7","Renal nephron cells":"3330.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"3.8","lung cancer":"3.6","Neuroblastoma":"4.4","Sarcoma":"3.9"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA040809":null,"HPA066746":null,"HPA075862":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RBKS","Gene synonym":["DKFZp686G13268","RBSK"],"Ensembl":"ENSG00000171174","Gene description":"Ribokinase","Uniprot":["Q9H477"],"Chromosome":"2","Position":"27781379-27890681","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Carbohydrate metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"43.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"171.4","Mast cells":"212.1","monocytes":"227.4","Neutrophils":"211.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA019725":null,"HPA028285":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"}},{"Gene":"RBM15","Gene synonym":["OTT","OTT1"],"Ensembl":"ENSG00000162775","Gene description":"RNA binding motif protein 15","Uniprot":["Q96T37"],"Chromosome":"1","Position":"110338506-110346681","Protein class":["Cancer-related genes","Disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["RNA-binding"],"Disease involvement":["Cancer-related genes","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"42.3"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":40,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB015201":null,"HPA019824":null,"HPA049642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.65e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"9494531.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"13302","Protein tissue specific Intensity":{"fallopian tube":"1039451.8","lymphoid tissue":"1440412.3","ovary":"1510769.4"},"Antibody":["HPA036645","HPA058136"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"52000","Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA036645":null,"HPA058136":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.56e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"}},{"Gene":"RBM27","Gene synonym":["ARRS1","KIAA1311","Psc1","ZC3H20"],"Ensembl":"ENSG00000091009","Gene description":"RNA binding motif protein 27","Uniprot":["Q9P2N5"],"Chromosome":"5","Position":"146203605-146289223","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"9.5","Megakaryocyte progenitors":"7.9","Megakaryocyte-Erythroid progenitors":"7.8","Retinal pigment epithelial cells":"8.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":13,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035944":null,"HPA036422":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.75e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"}},{"Gene":"RBM7","Gene synonym":[],"Ensembl":"ENSG00000076053","Gene description":"RNA binding motif protein 7","Uniprot":["Q9Y580"],"Chromosome":"11","Position":"114400030-114414203","Protein class":["Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"37.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"19.6","Cardiomyocytes":"63.6","Early spermatids":"14.1","Endometrial secretory cells":"7.1","Epicardial cells":"13.6","Late primary spermatocytes":"9.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"19.6","Myocytes":"63.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":85,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA013993":null,"HPA048003":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.31e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038912":null,"HPA051842":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB037218":null,"HPA068436":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.64e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"}},{"Gene":"RCOR3","Gene synonym":["FLJ10876"],"Ensembl":"ENSG00000117625","Gene description":"REST corepressor 3","Uniprot":["Q9P2K3"],"Chromosome":"1","Position":"211258377-211316385","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"540.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"540.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":53,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA007413":null,"HPA007621":null,"HPA071997":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 99: Retinal pigment epithelial cells - Retinol metabolism","Interactions":6,"Subcellular main location":["Lipid droplets"],"Subcellular additional location":null,"Antibody RRID":{"HPA049199":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"}},{"Gene":"RDH14","Gene synonym":["PAN2","SDR7C4"],"Ensembl":"ENSG00000240857","Gene description":"Retinol dehydrogenase 14","Uniprot":["Q9HBH5"],"Chromosome":"2","Position":"18554723-18560679","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA056686":null,"HPA078577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 53: Liver - Plasma proteins","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038518":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RDM1","Gene synonym":["MGC33977","RAD52B"],"Ensembl":"ENSG00000278023","Gene description":"RAD52 motif containing 1","Uniprot":["Q8NG50"],"Chromosome":"17","Position":"35918066-35930773","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["DNA-binding","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"11.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"9.3","Early spermatids":"51.9","Late primary spermatocytes":"22.9","Late spermatids":"113.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"113.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory CD8 T-cell":"2.6"},"RNA blood lineage specificity":"Lineage enhanced","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":{"T-cells":"2.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024794","HPA067546"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":4,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA024794":null,"HPA067546":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.07e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"6.1"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"REC8","Gene synonym":["kleisin-alpha","REC8L1","Rec8p"],"Ensembl":"ENSG00000100918","Gene description":"REC8 meiotic recombination protein","Uniprot":["O95072"],"Chromosome":"14","Position":"24171853-24180257","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Chromosome partition","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"33.5","pituitary gland":"64.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"46.2","Early spermatids":"149.9","Fallopian tube ciliated cells":"43.3","Late primary spermatocytes":"83.3","Late spermatids":"83.6","Respiratory ciliated cells":"33.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"43.3","Spermatogenic cell types":"149.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"30.0","Uterine Corpus Endometrial Carcinoma (TCGA)":"26.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"23.4","testis cancer":"23.9"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA031727":null,"HPA031729":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.47e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.60e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.42e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.02e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"}},{"Gene":"REEP3","Gene synonym":["C10orf74","Yip2b"],"Ensembl":"ENSG00000165476","Gene description":"Receptor accessory protein 3","Uniprot":["Q6NUK4"],"Chromosome":"10","Position":"63521401-63625128","Protein class":["Predicted membrane proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"471.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Skeletal muscle - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2435936.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"95635.8"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.53e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.51e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"}},{"Gene":"REEP4","Gene synonym":["C8orf20","FLJ22246","FLJ22277","PP432","Yip2c"],"Ensembl":"ENSG00000168476","Gene description":"Receptor accessory protein 4","Uniprot":["Q9H6H4"],"Chromosome":"8","Position":"22138020-22141951","Protein class":["Predicted membrane proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"90.4","skin 1":"91.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"351.0","Esophageal basal cells":"87.6","Esophageal suprabasal cells":"160.3","Late primary spermatocytes":"116.2","Migrating cytotrophoblasts":"66.4","Syncytiotrophoblasts":"118.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"351.0","Suprabasal cells":"160.3","Trophoblast cells":"118.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"29.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"2584982.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"784229.5","Stomach":"502143.2"},"Antibody":["HPA042683"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":145,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA042683":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.61e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"}},{"Gene":"REG4","Gene synonym":["GISP","REG-IV","RELP"],"Ensembl":"ENSG00000134193","Gene description":"Regenerating family member 4","Uniprot":["Q9BYZ8"],"Chromosome":"1","Position":"119794017-119811580","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"intestine":"623.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Goblet cells":"4100.5","Neuroendocrine cells":"5724.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Enteroendocrine cells":"5724.4","Goblet cells":"4100.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"748.7","Pancreatic Adenocarcinoma (TCGA)":"920.3","Rectum Adenocarcinoma (TCGA)":"425.5","Stomach Adenocarcinoma (TCGA)":"674.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"naive CD8 T-cell":"24.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"100","RNA blood lineage specific nTPM":{"T-cells":"24.7"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"colorectal cancer":"119.0","Esophageal cancer":"120.2","Gastric cancer":"177.8","pancreatic cancer":"62.6"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"135734","Protein tissue specific Intensity":{"intestine":"13573415.6"},"Antibody":["CAB025867","HPA046555"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to digestive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"190000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025867":null,"HPA046555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RER1","Gene synonym":[],"Ensembl":"ENSG00000157916","Gene description":"Retention in endoplasmic reticulum sorting receptor 1","Uniprot":["O15258"],"Chromosome":"1","Position":"2391775-2405442","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1550.1","Late primary spermatocytes":"593.7","Late spermatids":"653.0","Syncytiotrophoblasts":"612.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1550.1","Spermatogenic cell types":"653.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"18830363.0"},"Antibody":["CAB037240","HPA051400"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":74,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB037240":null,"HPA051400":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"}},{"Gene":"RETREG1","Gene synonym":["FAM134B","FLJ20152","JK1"],"Ensembl":"ENSG00000154153","Gene description":"Reticulophagy regulator 1","Uniprot":["Q9H6L5"],"Chromosome":"5","Position":"16473038-16617101","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":["Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"94.2","skeletal muscle":"117.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"797.7","Endometrial glandular cells":"525.6","Epididymal efferent duct absorptive cells":"436.9","Late spermatids":"1220.6","Myonuclei":"410.4","Podocytes":"806.0","Thymic myoid cells":"874.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"806.0","Spermatogenic cell types":"1220.6","Stromal cells":"874.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"9.4","T-cells":"8.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"534340.2","Microglia and Neuropil":"446474.1","Neurons":"397693.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"38","Protein tissue specific Intensity":{"cerebral cortex":"3806.6"},"Antibody":["HPA012077"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":9,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA012077":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.82e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"}},{"Gene":"RETREG2","Gene synonym":["C2orf17","FAM134A","MAG-2","MGC3035"],"Ensembl":"ENSG00000144567","Gene description":"Reticulophagy regulator family member 2","Uniprot":["Q8NC44"],"Chromosome":"2","Position":"219176225-219185475","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"235.9","Late spermatids":"305.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"305.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate basal glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2789688.3","kidney":"3272463.9"},"Antibody":["HPA011170","HPA011844","HPA075910"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA011170":null,"HPA011844":null,"HPA075910":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.28e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.81e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.61e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"REXO2","Gene synonym":["CGI-114","DKFZP566E144","SFN"],"Ensembl":"ENSG00000076043","Gene description":"RNA exonuclease 2","Uniprot":["Q9Y3B8"],"Chromosome":"11","Position":"114439435-114450279","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Exonuclease","Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"493.8","Esophageal apical cells":"1142.1","Esophageal suprabasal cells":"365.3","Late primary spermatocytes":"377.7","Oocytes":"1068.4","Parietal cells":"572.8","Syncytiotrophoblasts":"374.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1142.1","Oocytes":"1068.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038450","HPA038451"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Focal adhesion sites","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"300000","Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli","Focal adhesion sites"],"Antibody RRID":{"HPA038450":null,"HPA038451":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.71e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.83e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.65e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"}},{"Gene":"REXO5","Gene synonym":["NEF-sp"],"Ensembl":"ENSG00000005189","Gene description":"RNA exonuclease 5","Uniprot":["Q96IC2"],"Chromosome":"16","Position":"20806429-20849665","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Exonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"321.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"331.7","Early spermatids":"326.6","Epicardial cells":"450.3","Late primary spermatocytes":"1453.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"450.3","Spermatogenic cell types":"1453.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"15","RNA blood cell specific nTPM":{"basophil":"87.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"39","RNA blood lineage specific nTPM":{"granulocytes":"87.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040755","HPA040868","HPA066145"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear membrane","Nucleoli","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoli","Endoplasmic reticulum"],"Antibody RRID":{"HPA040755":null,"HPA040868":null,"HPA066145":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"}},{"Gene":"RFESD","Gene synonym":[],"Ensembl":"ENSG00000175449","Gene description":"Rieske Fe-S domain containing","Uniprot":["Q8TAC1"],"Chromosome":"5","Position":"95646777-95684773","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"16.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"81.4","Erythrocyte progenitors":"138.2","Erythrocytes":"35.0","Late primary spermatocytes":"52.0","Mast cells":"42.1","Oocytes":"179.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"81.4","Erythrocytes":"138.2","Oocytes":"179.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8100","Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB016546":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"}},{"Gene":"RFFL","Gene synonym":["CARP-2","CARP2","fring","rififylin","RNF189","RNF34L"],"Ensembl":"ENSG00000092871","Gene description":"Ring finger and FYVE like domain containing E3 ubiquitin protein ligase","Uniprot":["Q8WZ73"],"Chromosome":"17","Position":"35005990-35089319","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Apoptosis","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"85.4","Late spermatids":"151.6","Neutrophils":"75.0","Oligodendrocytes":"105.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"105.6","Spermatogenic cell types":"151.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"149.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":16,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB008096":null,"HPA017910":null,"HPA019492":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.09e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.03e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"RFPL4B","Gene synonym":["RNF211"],"Ensembl":"ENSG00000251258","Gene description":"Ret finger protein like 4B","Uniprot":["Q6ZWI9"],"Chromosome":"6","Position":"112347330-112351294","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"1.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Extravillous trophoblasts":"23.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Trophoblast cells":"23.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"Gastric cancer":"12.1","Rhabdoid":"20.8"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059324":null,"HPA066464":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RFX1","Gene synonym":["EF-C"],"Ensembl":"ENSG00000132005","Gene description":"Regulatory factor X1","Uniprot":["P22670"],"Chromosome":"19","Position":"13961530-14007039","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"27.6","Brain inhibitory neurons":"26.1","Choroid plexus epithelial cells":"25.4","Distal convoluted tubule cells":"27.0","Early spermatids":"35.8","Ependymal cells":"30.3","Late primary spermatocytes":"25.5","Late spermatids":"44.8","Loop of henle epithelial cells":"30.6","Microglia":"24.0","Other brain neurons":"20.8","Papillary tip epithelial cells":"25.7","Podocytes":"22.2","Proximal tubule cells":"34.5","Renal collecting duct intercalated cells":"23.6","Renal collecting duct principal cells":"25.9","Renal connecting tubule cells":"25.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"30.3","Ductal cells":"25.9","Glial cells":"24.0","Neuronal cells":"27.6","Renal nephron cells":"34.5","Spermatogenic cell types":"44.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"3.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":23,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA048722":null,"HPA052966":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":11,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Primary cilium","Basal body","Cytosol"],"Antibody RRID":{"HPA048969":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.70e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Vesicles","Cytosol"],"Antibody RRID":{"HPA035689":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.86e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.83e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"RFX4","Gene synonym":[],"Ensembl":"ENSG00000111783","Gene description":"Regulatory factor X4","Uniprot":["Q33E94"],"Chromosome":"12","Position":"106583004-106762803","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"22.2","testis":"70.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"688.3","Bergmann glia":"388.1","Early primary spermatocytes":"200.7","Ependymal cells":"415.8","Late primary spermatocytes":"152.5","Pituitary stem cells":"1319.0","Somatotrophs":"146.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"415.8","Glial cells":"688.3","Stem cells":"1319.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"astrocyte":"1093.3","Bergmann glia":"395.9","ependymal cell":"494.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"46","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"46.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA059745":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RGCC","Gene synonym":["bA157L14.2","C13orf15","RGC-32","RGC32"],"Ensembl":"ENSG00000102760","Gene description":"Regulator of cell cycle","Uniprot":["Q9H4X1"],"Chromosome":"13","Position":"41457550-41470871","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"391.7","lung":"668.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"384.3","Bergmann glia":"482.7","Breast lactating cells":"544.0","Breast secretory cells":"542.6","cDC":"375.2","Fallopian tube ciliated cells":"330.4","Hofbauer cells":"374.1","Innate lymphoid cells":"333.5","Late primary spermatocytes":"342.1","Neutrophil progenitors":"439.7","Schwann cells":"509.0","T-cells":"437.0","Vascular endothelial cells":"439.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"596.0","endothelial cell":"312.4","oligodendrocyte":"207.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"160.9","T-reg":"91.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"T-cells":"160.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"34.0"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"870000","Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA035638":null,"HPA063701":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":1,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA035979":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.68e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"}},{"Gene":"RGPD3","Gene synonym":["RGP3"],"Ensembl":"ENSG00000153165","Gene description":"RANBP2 like and GRIP domain containing 3","Uniprot":["A6NKT7"],"Chromosome":"2","Position":"106391290-106468413","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"5.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"7.8","Early primary spermatocytes":"8.5","Early spermatids":"43.8","Epicardial cells":"13.6","Hepatocytes":"15.9","Late primary spermatocytes":"23.7","Retinal bipolar cells":"9.0","Thymocytes":"9.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"13.6","Hepatocytes":"15.9","Spermatogenic cell types":"43.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"16.1","endothelial cell":"13.0","lower rhombic lip":"6.7","midbrain-derived inhibitory":"11.4"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Leukemia":"2.4"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"360673.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049497","HPA051675","HPA067564"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear membrane","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":3,"Subcellular main location":["Nuclear membrane","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049497":null,"HPA051675":null,"HPA067564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RGPD4","Gene synonym":["DKFZp686P0288","RGP4"],"Ensembl":"ENSG00000196862","Gene description":"RANBP2 like and GRIP domain containing 4","Uniprot":["Q7Z3J3"],"Chromosome":"2","Position":"107826892-107892544","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"2.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"10.6","Early primary spermatocytes":"5.8","Early spermatids":"20.5","Late primary spermatocytes":"17.1","Retinal bipolar cells":"8.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"10.6","Neuronal cells":"8.9","Spermatogenic cell types":"20.5"},"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":4,"Subcellular main location":["Nuclear membrane","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA049497":null,"HPA051675":null,"HPA067564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RGPD8","Gene synonym":["RanBP2alpha","RANBP2L1"],"Ensembl":"ENSG00000169629","Gene description":"RANBP2 like and GRIP domain containing 8","Uniprot":["O14715"],"Chromosome":"2","Position":"112368369-112434488","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"50.6","Lactotrophs":"40.9","Somatotrophs":"34.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"50.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":17,"Subcellular main location":["Nuclear membrane","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA045704":null,"HPA049497":null,"HPA051675":null,"HPA067564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - 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Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":"6","RNA pig brain regional specific nTPM":{"midbrain":"25.5","olfactory bulb":"55.9","thalamus":"29.6"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059149"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 99: Retinal pigment epithelial cells - Retinol metabolism","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA059149":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RGS22","Gene synonym":["CT145","DKFZP434I092","PRTD-NY2"],"Ensembl":"ENSG00000132554","Gene description":"Regulator of G protein signaling 22","Uniprot":["Q8NE09"],"Chromosome":"8","Position":"99960936-100131268","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Signal transduction inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"57.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"755.8","Ependymal cells":"526.7","Fallopian tube ciliated cells":"228.7","Late primary spermatocytes":"331.8","Late spermatids":"2834.8","Leydig cells":"432.6","Peritubular myoid cells":"205.4","Respiratory ciliated cells":"417.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2834.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"148.9","ependymal cell":"590.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"2.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Actin filaments","Cytosol"],"Antibody RRID":{"HPA053026":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"}},{"Gene":"RGS6","Gene synonym":[],"Ensembl":"ENSG00000182732","Gene description":"Regulator of G protein signaling 6","Uniprot":["P49758"],"Chromosome":"14","Position":"71932429-72566530","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation","Signal transduction inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"11.5","heart muscle":"10.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"395.2","Bergmann glia":"683.7","Brain excitatory neurons":"358.4","Brain inhibitory neurons":"393.2","Cardiomyocytes":"601.5","Corticotrophs":"741.2","Early spermatids":"349.3","Endometrial glandular cells":"401.9","Epicardial cells":"350.2","Late spermatids":"531.1","Other brain neurons":"336.3","Pericytes":"494.0","Pituicytes\/FSCs":"394.8","Platelets":"448.0","Renal connecting tubule cells":"439.6","Vascular smooth muscle cells":"1480.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"683.7","Mural cells":"1480.7","Myocytes":"601.5","Pituitary endocrine cells":"741.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"2367.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.0","Thyroid Carcinoma (TCGA)":"5.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"5.5"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Vesicles"],"Antibody RRID":{"HPA003067":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"}},{"Gene":"RGS8","Gene synonym":["MGC119067","MGC119068","MGC119069"],"Ensembl":"ENSG00000135824","Gene description":"Regulator of G protein signaling 8","Uniprot":["P57771"],"Chromosome":"1","Position":"182641816-182684587","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation","Signal transduction inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"26.7","retina":"28.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"43.9","Early spermatids":"23.0","Lactotrophs":"36.7","Late spermatids":"34.7","Retinal amacrine cells":"107.2","Retinal bipolar cells":"178.1","Somatotrophs":"13.9","Thyrotrophs":"35.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"178.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"79.5","thalamic excitatory":"67.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.5","Testicular Germ Cell Tumor (TCGA)":"2.2","Thyroid Carcinoma (TCGA)":"2.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"2.4","ovarian cancer":"7.3"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA076764":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RGSL1","Gene synonym":["RGSL2"],"Ensembl":"ENSG00000121446","Gene description":"Regulator of G protein signaling like 1","Uniprot":["A5PLK6"],"Chromosome":"1","Position":"182409192-182560599","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"4.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"24","RNA single cell type specific nCPM":{"Early spermatids":"178.5","Late primary spermatocytes":"137.2","Late spermatids":"48.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"36","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"178.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RHBDD1","Gene synonym":["DKFZp547E052"],"Ensembl":"ENSG00000144468","Gene description":"Rhomboid domain containing 1","Uniprot":["Q8TEB9"],"Chromosome":"2","Position":"226835581-226999215","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Apoptosis","Differentiation","Spermatogenesis"],"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Plasma cells":"261.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":29,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA013972":null,"HPA057125":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"RHBDD2","Gene synonym":["NPD007","RHBDL7"],"Ensembl":"ENSG00000005486","Gene description":"Rhomboid domain containing 2","Uniprot":["Q6NTF9"],"Chromosome":"7","Position":"75842602-75888926","Protein class":["Enzymes","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"348.9","choroid plexus":"356.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"178.5","Late spermatids":"530.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"530.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"400.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"7165155.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1152998.7"},"Antibody":["HPA045074","HPA051960"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA045074":null,"HPA051960":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.11e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.27e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"}},{"Gene":"RIBC2","Gene synonym":["C22orf11","DKFZp566F0546","FLJ25720"],"Ensembl":"ENSG00000128408","Gene description":"RIB43A domain with coiled-coils 2","Uniprot":["Q9H4K1"],"Chromosome":"22","Position":"45413693-45432509","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"choroid plexus":"12.6","fallopian tube":"9.2","testis":"28.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"53.3","Differentiating spermatogonia":"43.9","Early primary spermatocytes":"56.6","Early spermatids":"169.1","Endometrial ciliated cells":"98.5","Ependymal cells":"47.5","Epididymal efferent duct ciliated cells":"89.8","Fallopian tube ciliated cells":"92.9","Late primary spermatocytes":"381.5","Respiratory ciliated cells":"110.2","Respiratory deuterosomal cells":"79.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"110.2","Spermatogenic cell types":"381.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"21","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"41.2","ependymal cell":"54.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"10.5"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"30.7"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Prostate - Prostate glandular cells","Skin - Mitotic cells (Skin)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"22.1"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"134645","Protein cell type specific Intensity":{"Fallopian tube cells":"13464539.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"71611","Protein tissue specific Intensity":{"fallopian tube":"7161096.5"},"Antibody":["HPA003210"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Perinuclear theca","Calyx","Connecting piece","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":3,"Subcellular main location":["Connecting piece","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Perinuclear theca","Calyx"],"Antibody RRID":{"HPA003210":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.99e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"RIIAD1","Gene synonym":["C1orf230","FLJ36032","NCRNA00166"],"Ensembl":"ENSG00000178796","Gene description":"Regulatory subunit of type II PKA R-subunit domain containing 1","Uniprot":["A6NNX1"],"Chromosome":"1","Position":"151710433-151729805","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"23.4","pituitary gland":"13.0","testis":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"80.7","Early spermatids":"64.7","Endometrial ciliated cells":"151.1","Epididymal efferent duct ciliated cells":"230.0","Fallopian tube ciliated cells":"272.8","Late primary spermatocytes":"108.2","Late spermatids":"72.1","Neuroendocrine cells":"43.3","Oocytes":"55.3","Respiratory ciliated cells":"236.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"272.8","Neuronal cells":"80.7","Oocytes":"55.3","Spermatogenic cell types":"108.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"33.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"Neuroblastoma":"7.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Pancreas - Alpha cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"356","Protein cell type specific Intensity":{"Fallopian tube cells":"35568.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"76","Protein tissue specific Intensity":{"fallopian tube":"7598.0"},"Antibody":["HPA045703"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA045703":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"RIMBP2","Gene synonym":["KIAA0318","MGC15831","PPP1R133","RBP2","RIM-BP2"],"Ensembl":"ENSG00000060709","Gene description":"RIMS binding protein 2","Uniprot":["O15034"],"Chromosome":"12","Position":"130396133-130768228","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"18.7","parathyroid gland":"21.3","pituitary gland":"27.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"308.5","Choroid plexus epithelial cells":"453.9","Cone photoreceptor cells":"250.5","Corticotrophs":"205.5","Gonadotrophs":"274.7","Lactotrophs":"857.7","Neuroendocrine cells":"475.4","Pancreatic islet cells":"234.4","Somatotrophs":"1601.4","Thyrotrophs":"526.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"308.5","Ciliated cells":"453.9","Enteroendocrine cells":"475.4","Pituitary endocrine cells":"1601.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Neuroblastoma":"42.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Pancreas - Beta cells","Skin - Outer root sheath cells","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2790093.3","Microglia and Neuropil":"5677614.5","Neurons":"2622110.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"147546","Protein tissue specific Intensity":{"cerebral cortex":"14754582.1"},"Antibody":["HPA041494","HPA044114"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA041494":null,"HPA044114":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.75e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"}},{"Gene":"RIMBP3","Gene synonym":["KIAA1666","RIMBP3.1","RIMBP3A"],"Ensembl":"ENSG00000275793","Gene description":"RIMS binding protein 3","Uniprot":["Q9UFD9"],"Chromosome":"22","Position":"18605815-18611919","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"testis":"27.6"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"12.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":26,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA001183":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"}},{"Gene":"RIMBP3B","Gene synonym":[],"Ensembl":"ENSG00000274600","Gene description":"RIMS binding protein 3B","Uniprot":["A6NNM3"],"Chromosome":"22","Position":"21383751-21389478","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"28","RNA tissue specific nTPM":{"testis":"15.4"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"11.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 41: Non-specific - Nucleosome assembly","Single cell expression cluster":null,"Interactions":null,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA001183":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.16e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"}},{"Gene":"RIMBP3C","Gene synonym":[],"Ensembl":"ENSG00000183246","Gene description":"RIMS binding protein 3C","Uniprot":["A6NJZ7"],"Chromosome":"22","Position":"21545666-21551461","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"26","RNA tissue specific nTPM":{"testis":"6.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"38","RNA single cell type specific nCPM":{"Early spermatids":"27.9","Late primary spermatocytes":"42.8","Late spermatids":"78.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"94","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"78.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA001183":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RIMS1","Gene synonym":["CORD7","KIAA0340","RAB3IP2","RIM","RIM1"],"Ensembl":"ENSG00000079841","Gene description":"Regulating synaptic membrane exocytosis 1","Uniprot":["Q86UR5"],"Chromosome":"6","Position":"71886550-72403150","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Exocytosis","Neurotransmitter transport","Sensory transduction","Transport","Vision"],"Molecular function":null,"Disease involvement":["Cone-rod dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"59.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"1470.4","Brain inhibitory neurons":"680.9","Conjunctival goblet cells":"559.2","Corticotrophs":"767.8","Lactotrophs":"1100.6","Oligodendrocyte progenitor cells":"451.2","Other brain neurons":"665.5","Respiratory secretory cells":"438.5","Retinal amacrine cells":"397.6","Retinal bipolar cells":"528.8","Somatotrophs":"1212.3","Thyrotrophs":"1475.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"451.2","Goblet cells":"559.2","Neuronal cells":"1470.4","Pituitary endocrine cells":"1475.6","Secretory cells":"438.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"3566.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"4.4"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"7","RNA brain regional specific nTPM":{"cerebellum":"849.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.6","prostate cancer":"3.7"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Lactotropes","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"cerebellum":"470.0"},"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"25630206.2","Microglia and Neuropil":"17937132.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"354468","Protein tissue specific Intensity":{"cerebral cortex":"35446833.2"},"Antibody":["HPA076565"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA076565":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RIOK1","Gene synonym":["AD034","bA288G3.1","FLJ30006","RRP10"],"Ensembl":"ENSG00000124784","Gene description":"RIO kinase 1","Uniprot":["Q9BRS2"],"Chromosome":"6","Position":"7389793-7418037","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":["Hydrolase","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"116.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":92,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017866":null,"HPA051446":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.37e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"}},{"Gene":"RIOK3","Gene synonym":["SUDD"],"Ensembl":"ENSG00000101782","Gene description":"RIO kinase 3","Uniprot":["O14730"],"Chromosome":"18","Position":"23453287-23486603","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Antiviral defense","Immunity","Innate immunity","Ribosome biogenesis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"164.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1542.4","Neutrophil progenitors":"787.9","Neutrophils":"608.7","Ocular epithelial cells":"637.5","Platelets":"1067.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1542.4","Platelets":"1067.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":46,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Golgi apparatus","Centriolar satellite"],"Antibody RRID":{"HPA001620":null,"HPA024184":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.83e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"RIPOR2","Gene synonym":["C6orf32","DIFF48","FAM65B","KIAA0386","MYONAP"],"Ensembl":"ENSG00000111913","Gene description":"RHO family interacting cell polarization regulator 2","Uniprot":["Q9Y4F9"],"Chromosome":"6","Position":"24804282-25042170","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell adhesion","Chemotaxis","Differentiation","Hearing","Myogenesis"],"Molecular function":["Developmental protein","Signal transduction inhibitor"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"endometrium 1":"49.3","lymphoid tissue":"77.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"7916.5","Platelets":"2770.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"7916.5","Platelets":"2770.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"881.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"955.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"955.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"48.6"},"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Liver - Neutrophils","Lung - Neutrophils_2","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"54892052.3","T-cells":"46285010.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"6944027.3"},"Antibody":["HPA079394"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA079394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.94e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"}},{"Gene":"RLBP1","Gene synonym":["CRALBP"],"Ensembl":"ENSG00000140522","Gene description":"Retinaldehyde binding protein 1","Uniprot":["P12271"],"Chromosome":"15","Position":"89209869-89221614","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Transport","Vision"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"retina":"246.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"90","RNA single cell type specific nCPM":{"M\u00fcller glia":"2970.2","Retinal pigment epithelial cells":"2510.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"90","RNA single cell type group specific nCPM":{"Glial cells":"2970.2","Pigment cells":"2510.9"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"astrocyte":"17.1","Bergmann glia":"8.3","choroid plexus epithelial cell":"8.6","oligodendrocyte precursor cell":"6.9"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"28","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.0","Skin Cutaneous Melanoma (TCGA)":"15.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"13","RNA cell line specific nTPM":{"Bile duct cancer":"10.4","colorectal cancer":"3.5","skin cancer":"9.4"},"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"169244.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4043","Protein tissue specific Intensity":{"cerebral cortex":"404300.5"},"Antibody":["HPA042051","HPA044083"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Approved","Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Centrosome"],"Antibody RRID":{"HPA042051":null,"HPA044083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RLN1","Gene synonym":["H1"],"Ensembl":"ENSG00000107018","Gene description":"Relaxin 1","Uniprot":["P04808"],"Chromosome":"9","Position":"5334930-5339876","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"72","RNA tissue specific nTPM":{"prostate":"22.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"2.5","Epididymal efferent duct ciliated cells":"2.5","Fallopian tube ciliated cells":"7.0","Innate lymphoid cells":"2.5","Platelets":"2.8","Prostatic glandular cells":"19.2","Respiratory ionocytes":"2.5","Undifferentiated spermatogonia":"3.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"7.0","Glandular cells":"19.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"1.1","leukocyte":"1.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"275","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"112.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"59","RNA cell line specific nTPM":{"prostate cancer":"6.5"},"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":17,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RLN2","Gene synonym":["bA12D24.1.1","bA12D24.1.2","H2","RLXH2"],"Ensembl":"ENSG00000107014","Gene description":"Relaxin 2","Uniprot":["P04090"],"Chromosome":"9","Position":"5299864-5304716","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"4.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct ciliated cells":"16.8","Fallopian tube ciliated cells":"9.3","Late primary spermatocytes":"29.5","Megakaryocytes":"12.4","Oocytes":"59.9","Syncytiotrophoblasts":"15.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"16.8","Oocytes":"59.9","Spermatogenic cell types":"29.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1.6","endothelial cell":"1.9","ependymal cell":"1.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"8.2","Prostate Adenocarcinoma (TCGA)":"19.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"26","RNA blood cell specific nTPM":{"gdT-cell":"1.4","MAIT T-cell":"4.2","memory B-cell":"1.9","memory CD4 T-cell":"2.8","memory CD8 T-cell":"2.3","naive B-cell":"1.4","naive CD4 T-cell":"4.0","naive CD8 T-cell":"3.0","NK-cell":"3.5","T-reg":"1.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"33","RNA blood lineage specific nTPM":{"B-cells":"1.9","NK-cells":"3.5","T-cells":"4.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"6.3"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":24400,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.85e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.26e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-6"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":19,"Subcellular main location":["Mitotic spindle","Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA034705":null,"HPA034706":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.51e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.16e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"}},{"Gene":"RMND5B","Gene synonym":["FLJ22318","GID2","GID2B"],"Ensembl":"ENSG00000145916","Gene description":"Required for meiotic nuclear division 5 homolog B","Uniprot":["Q96G75"],"Chromosome":"5","Position":"178130996-178150568","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"168.2","Esophageal apical cells":"527.4","Late primary spermatocytes":"278.6","Late spermatids":"753.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"527.4","Spermatogenic cell types":"753.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":27,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047778":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.79e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.28e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"}},{"Gene":"RNASE11","Gene synonym":["C14orf6","RAJ1"],"Ensembl":"ENSG00000173464","Gene description":"Ribonuclease A family member 11 (inactive)","Uniprot":["Q8TAA1"],"Chromosome":"14","Position":"20582892-20609884","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"epididymis":"622.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"24.5","Epididymal principal cells":"18.8","Late spermatids":"53.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"86","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"18.8","Spermatogenic cell types":"53.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA003724":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RNASE12","Gene synonym":["RAI1"],"Ensembl":"ENSG00000258436","Gene description":"Ribonuclease A family member 12 (inactive)","Uniprot":["Q5GAN4"],"Chromosome":"14","Position":"20590073-20591376","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"284","RNA tissue specific nTPM":{"epididymis":"656.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Epididymal clear cells":"2.0","Epididymal principal cells":"1.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"2.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044175":null,"HPA059465":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RNF10","Gene synonym":["KIAA0262","RIE2"],"Ensembl":"ENSG00000022840","Gene description":"Ring finger protein 10","Uniprot":["Q8N5U6"],"Chromosome":"12","Position":"120533480-120577588","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["DNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"459.7","Neutrophils":"596.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"596.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"173","Protein cell type specific Intensity":{"Neurons":"17258.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052643"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":39,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA052643":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"RNF11","Gene synonym":["CGI-123","MGC51169","Sid1669p"],"Ensembl":"ENSG00000123091","Gene description":"Ring finger protein 11","Uniprot":["Q9Y3C5"],"Chromosome":"1","Position":"51236273-51273447","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"698.9","Neutrophils":"347.6","Platelets":"742.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"698.9","Platelets":"742.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"22.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":200,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045781":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.55e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"}},{"Gene":"RNF113B","Gene synonym":["RNF161","ZNF183L1"],"Ensembl":"ENSG00000139797","Gene description":"Ring finger protein 113B","Uniprot":["Q8IZP6"],"Chromosome":"13","Position":"98175785-98177269","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"173","RNA tissue specific nTPM":{"testis":"44.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Late primary spermatocytes":"202.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"44","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"202.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":24,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021184":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":25,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA041514":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.57e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.78e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"RNF126","Gene synonym":["FLJ20552"],"Ensembl":"ENSG00000070423","Gene description":"Ring finger protein 126","Uniprot":["Q9BV68"],"Chromosome":"19","Position":"647526-663233","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"143.8","Esophageal apical cells":"167.3","Esophageal basal cells":"175.9","Esophageal suprabasal cells":"164.9","Extravillous trophoblasts":"174.0","Late primary spermatocytes":"284.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"284.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":38,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA043050":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RNF138","Gene synonym":["NARF","STRIN"],"Ensembl":"ENSG00000134758","Gene description":"Ring finger protein 138","Uniprot":["Q8WVD3"],"Chromosome":"18","Position":"32091874-32131561","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Ubl conjugation pathway","Wnt signaling pathway"],"Molecular function":["DNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"90.6","testis":"113.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late spermatids":"7000.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"38","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"7000.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA041101":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.01e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"}},{"Gene":"RNF139","Gene synonym":["HRCA1","RCA1","TRC8"],"Ensembl":"ENSG00000170881","Gene description":"Ring finger protein 139","Uniprot":["Q8WU17"],"Chromosome":"8","Position":"124474880-124488618","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Receptor","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"88.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"964.6","Late spermatids":"1594.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1594.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA001202":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.12e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.44e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"}},{"Gene":"RNF141","Gene synonym":["ZFP26","ZNF230"],"Ensembl":"ENSG00000110315","Gene description":"Ring finger protein 141","Uniprot":["Q8WVD5"],"Chromosome":"11","Position":"10511673-10541230","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1167.9","Esophageal apical cells":"695.9","Late primary spermatocytes":"326.7","Late spermatids":"838.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"695.9","Spermatogenic cell types":"1167.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"98.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Skin - Keratinocyte (other)","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"1293475.8","Pancreas epithelial cells":"1192166.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2172609.7","pancreas":"2276030.1"},"Antibody":["HPA018133"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA018133":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.59e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"}},{"Gene":"RNF148","Gene synonym":["MGC35222"],"Ensembl":"ENSG00000235631","Gene description":"Ring finger protein 148","Uniprot":["Q8N7C7"],"Chromosome":"7","Position":"122701668-122702922","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"86","RNA tissue specific nTPM":{"testis":"48.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"8.7","Late primary spermatocytes":"3.9","Late spermatids":"2.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"53","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"8.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"22.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"320","Protein tissue specific Intensity":{"skin":"31991.3"},"Antibody":["HPA045587"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045587":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RNF168","Gene synonym":["FLJ35794"],"Ensembl":"ENSG00000163961","Gene description":"Ring finger protein 168","Uniprot":["Q8IYW5"],"Chromosome":"3","Position":"196468783-196503768","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Ubl conjugation pathway"],"Molecular function":["Chromatin regulator","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"312.1","Late spermatids":"734.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"734.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"142562.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"17306.5"},"Antibody":["HPA046109"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA046109":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.39e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.94e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"}},{"Gene":"RNF175","Gene synonym":["FLJ34190"],"Ensembl":"ENSG00000145428","Gene description":"Ring finger protein 175","Uniprot":["Q8N4F7"],"Chromosome":"4","Position":"153710160-153760024","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"26.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"85.8","Brain inhibitory neurons":"111.7","Early spermatids":"63.2","Late primary spermatocytes":"65.0","Neutrophils":"87.2","Oligodendrocyte progenitor cells":"49.4","Other brain neurons":"96.5","Pituitary stem cells":"366.6","Retinal ganglion cells":"50.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"111.7","Neutrophils":"87.2","Stem cells":"366.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"8.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"2.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"4.4","skin cancer":"3.9"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035837":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.88e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":19,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA046112":null,"HPA062121":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.06e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"}},{"Gene":"RNF183","Gene synonym":["MGC4734"],"Ensembl":"ENSG00000165188","Gene description":"Ring finger protein 183","Uniprot":["Q96D59"],"Chromosome":"9","Position":"113297093-113303376","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Apoptosis","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"15.3","kidney":"9.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial luminal cells":"39.5","Epididymal efferent duct absorptive cells":"20.6","Epididymal efferent duct ciliated cells":"40.3","Epididymal principal cells":"53.9","Esophageal apical cells":"22.9","Mucous neck cells":"15.6","Proximal tubule cells":"30.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"40.3","Luminal cells":"39.5","Renal nephron cells":"30.9","Reproductive supporting cells":"53.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"1.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"26.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"2.2"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":35,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"}},{"Gene":"RNF19A","Gene synonym":["DKFZp566B1346","dorfin","RNF19"],"Ensembl":"ENSG00000034677","Gene description":"Ring finger protein 19A, RBR E3 ubiquitin protein ligase","Uniprot":["Q9NV58"],"Chromosome":"8","Position":"100257060-100336218","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"1004.5","T-cells":"702.4","Urothelial cells":"897.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"1004.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB011455","HPA023652"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB011455":null,"HPA023652":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.25e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.64e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.97e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"}},{"Gene":"RNF19B","Gene synonym":["FLJ90005","IBRDC3","NKLAM"],"Ensembl":"ENSG00000116514","Gene description":"Ring finger protein 19B","Uniprot":["Q6ZMZ0"],"Chromosome":"1","Position":"32936445-32964809","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Immunity","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"73.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"1022.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"1022.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"67.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"16.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"16.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049587","HPA063640"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":33,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA049587":null,"HPA063640":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.49e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.11e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"}},{"Gene":"RNF20","Gene synonym":["BRE1","BRE1A","FLJ11189","FLJ20382","hBRE1","KAIA2779"],"Ensembl":"ENSG00000155827","Gene description":"Ring finger protein 20","Uniprot":["Q5VTR2"],"Chromosome":"9","Position":"101533853-101563344","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["Chromatin regulator","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"154.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"154.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"28622594.7"},"Antibody":["CAB012478","HPA029442","HPA051773"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":58,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB012478":null,"HPA029442":null,"HPA051773":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.07e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.41e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"}},{"Gene":"RNF225","Gene synonym":[],"Ensembl":"ENSG00000269855","Gene description":"Ring finger protein 225","Uniprot":["M0QZC1"],"Chromosome":"19","Position":"58395656-58397079","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"2.6","esophagus":"5.6","skin 1":"4.2","vagina":"2.4"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"1.1"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RNF32","Gene synonym":["FKSG33","HSD15","LMBR2"],"Ensembl":"ENSG00000105982","Gene description":"Ring finger protein 32","Uniprot":["Q9H0A6"],"Chromosome":"7","Position":"156640281-156677130","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"56.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"282.3","Late primary spermatocytes":"550.2","Late spermatids":"780.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"780.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"31.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"12.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"12.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019516","HPA073560"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":10,"Subcellular main location":["Nuclear bodies","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019516":null,"HPA073560":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.44e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"}},{"Gene":"RNF38","Gene synonym":[],"Ensembl":"ENSG00000137075","Gene description":"Ring finger protein 38","Uniprot":["Q9H0F5"],"Chromosome":"9","Position":"36336396-36487548","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"664.0","Late spermatids":"2377.2","Sertoli cells":"585.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2377.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015853"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA015853":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.63e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.56e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"}},{"Gene":"RNF41","Gene synonym":["NRDP1","SBBI03"],"Ensembl":"ENSG00000181852","Gene description":"Ring finger protein 41","Uniprot":["Q9H4P4"],"Chromosome":"12","Position":"56202179-56221933","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Apoptosis","Autophagy","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"103.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"1505665.6","Microglia and Neuropil":"527684.7","Neurons":"618393.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"271","Protein tissue specific Intensity":{"cerebral cortex":"27134.6"},"Antibody":["HPA016812"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Midbody ring"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":67,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Midbody ring"],"Antibody RRID":{"HPA016812":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.83e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"}},{"Gene":"RNF6","Gene synonym":["DKFZp686P0776"],"Ensembl":"ENSG00000127870","Gene description":"Ring finger protein 6","Uniprot":["Q9Y252"],"Chromosome":"13","Position":"26132115-26222314","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"97.1","Late primary spermatocytes":"163.9","Late spermatids":"238.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"238.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"85783.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039343","HPA040048"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":12,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA039343":null,"HPA040048":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.48e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"}},{"Gene":"RNF7","Gene synonym":["CKBBP1","RBX2","ROC2","SAG"],"Ensembl":"ENSG00000114125","Gene description":"Ring finger protein 7","Uniprot":["Q9UBF6"],"Chromosome":"3","Position":"141738249-141747560","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"42.5","Late spermatids":"72.5","Papillary tip epithelial cells":"21.0","Tuft cells":"23.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"72.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036995"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":71,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA036995":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.23e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.49e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.71e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.83e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"RNFT1","Gene synonym":["PTD016"],"Ensembl":"ENSG00000189050","Gene description":"Ring finger protein, transmembrane 1","Uniprot":["Q5M7Z0"],"Chromosome":"17","Position":"59952240-59964761","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"60.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"180.4","Early spermatids":"242.7","Late primary spermatocytes":"440.2","Late spermatids":"105.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"440.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"850687.0","Pancreas epithelial cells":"594400.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA013739"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA013739":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"}},{"Gene":"RNFT2","Gene synonym":["FLJ14627","TMEM118"],"Ensembl":"ENSG00000135119","Gene description":"Ring finger protein, transmembrane 2","Uniprot":["Q96EX2"],"Chromosome":"12","Position":"116738178-116853631","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"10.3","choroid plexus":"4.7","pituitary gland":"4.9","retina":"4.6","testis":"6.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"42.5","Corticotrophs":"41.9","Early spermatids":"56.7","Gonadotrophs":"46.2","Lactotrophs":"48.1","Late spermatids":"98.4","Retinal amacrine cells":"50.6","Retinal bipolar cells":"50.4","Retinal ganglion cells":"46.4","Rod photoreceptor cells":"56.2","Somatotrophs":"44.6","Thyrotrophs":"66.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"56.2","Pituitary endocrine cells":"66.6","Spermatogenic cell types":"98.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"10.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA064161":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.35e-4"}},{"Gene":"RNGTT","Gene synonym":["hCAP","HCE","HCE1"],"Ensembl":"ENSG00000111880","Gene description":"RNA guanylyltransferase and 5'-phosphatase","Uniprot":["O60942"],"Chromosome":"6","Position":"88609897-88963618","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","mRNA capping","mRNA processing"],"Molecular function":["Hydrolase","Multifunctional enzyme","Nucleotidyltransferase","Protein phosphatase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"425.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"2624696.5","Neutrophils":"2211199.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"400313.9","Stomach":"424347.3"},"Antibody":["HPA003750"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.33e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.33e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":38,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA052530":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ROPN1B","Gene synonym":[],"Ensembl":"ENSG00000114547","Gene description":"Rhophilin associated tail protein 1B","Uniprot":["Q9BZX4"],"Chromosome":"3","Position":"125969160-125983454","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"204.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"13","RNA single cell type specific nCPM":{"Early spermatids":"2018.9","Late primary spermatocytes":"1856.8","Late spermatids":"2378.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2378.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"41.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"skin cancer":"29.4"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":1,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA052530":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.98e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.33e-4"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ROPN1L","Gene synonym":["ASP","FLJ25776","RSPH11"],"Ensembl":"ENSG00000145491","Gene description":"Rhophilin associated tail protein 1 like","Uniprot":["Q96C74"],"Chromosome":"5","Position":"10441524-10472029","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"304.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"2979.4","Late primary spermatocytes":"3415.0","Late spermatids":"4288.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4288.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"ependymal cell":"359.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"13.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"basophil":"45.2","eosinophil":"55.2","neutrophil":"105.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"granulocytes":"105.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":6,"Subcellular main location":["Primary cilium transition zone","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Nucleoplasm","Vesicles"],"Antibody RRID":{"HPA039193":null,"HPA041830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.74e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - 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Adrenal cortex cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1674","Protein cell type specific Intensity":{"Neurons":"167421.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008393"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA008393":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RP1","Gene synonym":["DCDC4A","ORP1"],"Ensembl":"ENSG00000104237","Gene description":"RP1 axonemal microtubule associated","Uniprot":["P56715"],"Chromosome":"8","Position":"54509422-54871720","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"retina":"218.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"211.2","Endometrial ciliated cells":"658.9","Fallopian tube ciliated cells":"586.5","Loop of henle epithelial cells":"330.2","Respiratory ciliated cells":"2984.6","Rod photoreceptor cells":"946.4","Transitional alveolar cells":"340.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"2984.6","Neuronal cells":"946.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"endothelial cell":"88.0","ependymal cell":"31.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Lung - Respiratory ciliated cells","Stomach - Parietal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"2.9"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"56887","Protein cell type specific Intensity":{"Fallopian tube cells":"5688735.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"54556","Protein tissue specific Intensity":{"fallopian tube":"5455562.1"},"Antibody":["HPA027253","HPA042257"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA027253":null,"HPA042257":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"}},{"Gene":"RPF1","Gene synonym":["BXDC5"],"Ensembl":"ENSG00000117133","Gene description":"Ribosome production factor 1 homolog","Uniprot":["Q9H9Y2"],"Chromosome":"1","Position":"84479259-84498352","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis","rRNA processing"],"Molecular function":["RNA-binding","rRNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"197.3","Oocytes":"211.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"211.8","Spermatogenic cell types":"197.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":47,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA024642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.30e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.78e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.63e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"}},{"Gene":"RPF2","Gene synonym":["bA397G5.4","BXDC1","FLJ21087"],"Ensembl":"ENSG00000197498","Gene description":"Ribosome production factor 2 homolog","Uniprot":["Q9H7B2"],"Chromosome":"6","Position":"110982015-111028263","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"192.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":66,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm","Mitotic chromosome"],"Antibody RRID":{"HPA035475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.91e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.13e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.69e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.97e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"}},{"Gene":"RPGRIP1","Gene synonym":["CORD13","LCA6","RGI1","RPGRIP"],"Ensembl":"ENSG00000092200","Gene description":"RPGR interacting protein 1","Uniprot":["Q96KN7"],"Chromosome":"14","Position":"21280083-21351301","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Ciliopathy","Cone-rod dystrophy","Disease variant","Glaucoma","Leber congenital amaurosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"82","RNA tissue specific nTPM":{"retina":"171.2","testis":"55.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"979.2","Rod photoreceptor cells":"602.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"979.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"11.9","hippocampal CA4":"3.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"3.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"8.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"28","RNA blood lineage specific nTPM":{"dendritic cells":"3.2","granulocytes":"8.8","monocytes":"3.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"275","Protein tissue specific Intensity":{"lung":"27518.8"},"Antibody":["HPA042955","HPA060190"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Vesicles","Microtubules","Cytokinetic bridge","Primary cilium","Primary cilium tip","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":28,"Subcellular main location":["Vesicles","Microtubules","Primary cilium"],"Subcellular additional location":["Cytokinetic bridge","Primary cilium tip","Cytosol"],"Antibody RRID":{"HPA042955":null,"HPA060190":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RPGRIP1L","Gene synonym":["CORS3","FTM","JBTS7","KIAA1005","MKS5","NPHP8","PPP1R134"],"Ensembl":"ENSG00000103494","Gene description":"RPGRIP1 like","Uniprot":["Q68CZ1"],"Chromosome":"16","Position":"53598153-53703938","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome","Meckel syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"12.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"98.0","Ependymal cells":"270.7","Fallopian tube ciliated cells":"85.7","Lactotrophs":"94.8","Respiratory ciliated cells":"177.4","Somatotrophs":"98.7","Thyrotrophs":"102.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"270.7","Pituitary endocrine cells":"102.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"306.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"11220651.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"12518336.4"},"Antibody":["HPA039405","HPA040530"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Primary cilium","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":48,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Primary cilium","Basal body"],"Antibody RRID":{"HPA039405":null,"HPA040530":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.90e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"}},{"Gene":"RPH3A","Gene synonym":["exophilin-1","KIAA0985","rabphilin"],"Ensembl":"ENSG00000089169","Gene description":"Rabphilin 3A","Uniprot":["Q9Y2J0"],"Chromosome":"12","Position":"112570380-112898881","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"115.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"88.0","Brain excitatory neurons":"100.5","Brain inhibitory neurons":"145.8","Ependymal cells":"151.6","Neutrophils":"244.9","Oligodendrocyte progenitor cells":"41.5","Other brain neurons":"220.1","Retinal amacrine cells":"125.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"151.6","Glial cells":"88.0","Neuronal cells":"220.1","Neutrophils":"244.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"16.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"classical monocyte":"6.3","intermediate monocyte":"3.0","neutrophil":"2.2","non-classical monocyte":"4.6"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"2.2","monocytes":"6.3"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Myeloma":"7.4","Neuroblastoma":"17.0"},"RNA tissue cell type enrichment":["Adipose visceral - Neutrophils","Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"382329","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"32589489.3","Microglia and Neuropil":"61833253.1","Neurons":"20276077.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1974497","Protein tissue specific Intensity":{"cerebral cortex":"197449692.6"},"Antibody":["HPA002475"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA002475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RPL10L","Gene synonym":[],"Ensembl":"ENSG00000165496","Gene description":"Ribosomal protein L10 like","Uniprot":["Q96L21"],"Chromosome":"14","Position":"46651010-46651781","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":["Differentiation","Meiosis","Spermatogenesis"],"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"35","RNA tissue specific nTPM":{"testis":"91.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Early spermatids":"527.2","Late primary spermatocytes":"892.1","Late spermatids":"279.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"150","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"892.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"16","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"10.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"11.2"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"824","Protein cell type specific Intensity":{"Skeletal myofibers":"82387.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011311"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":25,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA011311":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RPL26L1","Gene synonym":["RPL26P1"],"Ensembl":"ENSG00000037241","Gene description":"Ribosomal protein L26 like 1","Uniprot":["Q9UNX3"],"Chromosome":"5","Position":"172958729-172969771","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"187.9","Early spermatids":"333.6","Late primary spermatocytes":"611.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"611.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"993943.7","Neurons":"975484.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"644145.4","pancreas":"844684.3"},"Antibody":["HPA030449"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":155,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA030449":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.09e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.83e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.11e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"}},{"Gene":"RPL36AL","Gene synonym":["RPL36A","RPL36AP42"],"Ensembl":"ENSG00000165502","Gene description":"Ribosomal protein L36a like","Uniprot":["Q969Q0"],"Chromosome":"14","Position":"49618530-49620626","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","Ribosomal protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"2928.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2928.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"32792028.2","Pancreatic islets":"40594011.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"49939463.0"},"Antibody":["HPA077586"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":126,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA077586":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.78e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA047105":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":57,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Microtubule ends","Cytosol"],"Antibody RRID":{"HPA037578":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.32e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.04e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.02e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"}},{"Gene":"RPP38","Gene synonym":[],"Ensembl":"ENSG00000152464","Gene description":"Ribonuclease P\/MRP subunit p38","Uniprot":["P78345"],"Chromosome":"10","Position":"15097180-15139818","Protein class":["Essential proteins","Predicted intracellular proteins","Ribosomal proteins"],"Biological process":["rRNA processing","tRNA processing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"188.2","Early spermatids":"551.0","Late primary spermatocytes":"416.3","Late spermatids":"306.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"551.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":28,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA045128":null,"HPA050398":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"}},{"Gene":"RPUSD3","Gene synonym":["MGC29784"],"Ensembl":"ENSG00000156990","Gene description":"RNA pseudouridine synthase D3","Uniprot":["Q6P087"],"Chromosome":"3","Position":"9837849-9844602","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing"],"Molecular function":["Isomerase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"80.2","Late primary spermatocytes":"177.1","Megakaryocytes":"80.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"177.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"503919.6","Neurons":"443230.0","Pancreas epithelial cells":"450699.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037551","HPA037552"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA037551":null,"HPA037552":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.28e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.15e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"}},{"Gene":"RSBN1L","Gene synonym":["FLJ42526","FLJ45813","MGC71764"],"Ensembl":"ENSG00000187257","Gene description":"Round spermatid basic protein 1 like","Uniprot":["Q6PCB5"],"Chromosome":"7","Position":"77696459-77783022","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Dioxygenase","Oxidoreductase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"54.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"54.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"461325.4","Fallopian tube cells":"670260.8","T-cells":"938281.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"429349.3"},"Antibody":["HPA020406","HPA020413"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":33,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA020406":null,"HPA020413":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"}},{"Gene":"RSPH1","Gene synonym":["CILD24","FLJ32753","RSP44","RSPH10A","TSGA2"],"Ensembl":"ENSG00000160188","Gene description":"Radial spoke head component 1","Uniprot":["Q8WYR4"],"Chromosome":"21","Position":"42472486-42496246","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"108.8","fallopian tube":"151.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"1007.0","Ependymal cells":"586.4","Epididymal efferent duct ciliated cells":"813.4","Fallopian tube ciliated cells":"1410.0","Respiratory ciliated cells":"1689.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"1689.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"ependymal cell":"653.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"58.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"plasmacytoid DC":"3.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"dendritic cells":"3.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Centrosome","Basal body","Mid piece"],"Subcellular additional location":["Acrosome"],"Antibody RRID":{"HPA016816":null,"HPA017382":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"}},{"Gene":"RSPH10B","Gene synonym":[],"Ensembl":"ENSG00000155026","Gene description":"Radial spoke head 10 homolog B","Uniprot":["P0C881"],"Chromosome":"7","Position":"5925550-5970689","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"7.9","testis":"18.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"236.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"236.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"3.4","ependymal cell":"7.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"4.1","Testicular Germ Cell Tumor (TCGA)":"2.6","Uterine Corpus Endometrial Carcinoma (TCGA)":"5.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Primary cilium"],"Subcellular additional location":["Plasma membrane","Microtubules","Cytosol"],"Antibody RRID":{"HPA049182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"}},{"Gene":"RSPH10B2","Gene synonym":[],"Ensembl":"ENSG00000169402","Gene description":"Radial spoke head 10 homolog B2","Uniprot":["B2RC85"],"Chromosome":"7","Position":"6754103-6799365","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"9.5","testis":"18.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"29.3","Endometrial ciliated cells":"11.0","Ependymal cells":"29.3","Epicardial cells":"9.1","Epididymal efferent duct ciliated cells":"9.2","Fallopian tube ciliated cells":"21.9","Late primary spermatocytes":"23.2","Late spermatids":"113.0","Respiratory ciliated cells":"24.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"29.3","Spermatogenic cell types":"113.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"ependymal cell":"27.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Primary cilium"],"Subcellular additional location":["Plasma membrane","Microtubules","Cytosol"],"Antibody RRID":{"HPA049182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RSPH14","Gene synonym":["RTDR1"],"Ensembl":"ENSG00000100218","Gene description":"Radial spoke head 14 homolog","Uniprot":["Q9UHP6"],"Chromosome":"22","Position":"23059415-23145021","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"11.6","testis":"24.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"190.6","Ependymal cells":"46.0","Epididymal efferent duct ciliated cells":"48.7","Fallopian tube ciliated cells":"62.8","Late primary spermatocytes":"85.1","Late spermatids":"415.5","Megakaryocytes":"68.0","Platelets":"63.4","Respiratory ciliated cells":"138.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"138.1","Spermatogenic cell types":"415.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"53.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"20.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"neutrophil":"7.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"7.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":42,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA018420":null,"HPA050425":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Plasma membrane","Flagellar centriole","Mid piece","Annulus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039109":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.26e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Connecting piece","Flagellar centriole"],"Subcellular additional location":["Annulus"],"Antibody RRID":{"HPA031196":null,"HPA031197":null,"HPA031198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"}},{"Gene":"RSPH6A","Gene synonym":["RSHL1","RSP4","RSP6","RSPH4B"],"Ensembl":"ENSG00000104941","Gene description":"Radial spoke head 6 homolog A","Uniprot":["Q9H0K4"],"Chromosome":"19","Position":"45795713-45815308","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"testis":"28.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"79.0","Late primary spermatocytes":"157.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"157.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"3.5"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045382":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":7,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":["Acrosome","Equatorial segment"],"Antibody RRID":{"HPA031703":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.74e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"RSPO4","Gene synonym":["C20orf182","dJ824F16.3"],"Ensembl":"ENSG00000101282","Gene description":"R-spondin 4","Uniprot":["Q2I0M5"],"Chromosome":"20","Position":"958452-1002311","Protein class":["Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":["Sensory transduction","Wnt signaling pathway"],"Molecular function":["Heparin-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.2","lung":"11.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"20.0","Bergmann glia":"14.9","Choroid plexus epithelial cells":"12.2","Early spermatids":"20.5","Ependymal cells":"51.8","Epididymal efferent duct ciliated cells":"11.3","Gonadotrophs":"15.0","Late spermatids":"25.4","Other brain neurons":"21.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"51.8","Glial cells":"20.0","Neuronal cells":"21.7","Spermatogenic cell types":"25.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"70.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"9.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"8.8"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"basal ganglia":"1.2"},"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048887"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048887":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.70e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"}},{"Gene":"RSRC1","Gene synonym":["BM-011","MGC12197","SFRS21","SRrp53"],"Ensembl":"ENSG00000174891","Gene description":"Arginine and serine rich coiled-coil 1","Uniprot":["Q96IZ7"],"Chromosome":"3","Position":"158105855-158545730","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":42,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA044792":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.01e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"}},{"Gene":"RTKN2","Gene synonym":["bA531F24.1","Em:AC024597.2","FLJ39352","PLEKHK1"],"Ensembl":"ENSG00000182010","Gene description":"Rhotekin 2","Uniprot":["Q8IZC4"],"Chromosome":"10","Position":"62183035-62268844","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"lung":"73.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"287.9","Early spermatids":"496.3","Esophageal apical cells":"392.6","Esophageal suprabasal cells":"90.0","Late primary spermatocytes":"310.3","Late spermatids":"136.1","Oocytes":"138.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"287.9","Apical squamous epithelial cells":"392.6","Spermatogenic cell types":"496.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"33.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"T-reg":"16.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"73","RNA blood lineage specific nTPM":{"T-cells":"16.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - T-cells","Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Alveolar cells type 1","Pituitary gland - Somatotropes","Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"5451","Protein cell type specific Intensity":{"Alveolar cell types":"545075.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"803204","Protein tissue specific Intensity":{"lung":"80320406.8"},"Antibody":["HPA037946","HPA038446"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA037946":null,"HPA038446":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2600000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":147,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB005388":null,"HPA023977":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.02e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.30e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"}},{"Gene":"RTP1","Gene synonym":["MGC35450","Z3CXXC1"],"Ensembl":"ENSG00000175077","Gene description":"Receptor transporter protein 1","Uniprot":["P59025"],"Chromosome":"3","Position":"187197486-187201462","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"2.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"2.6","Late primary spermatocytes":"7.8","Late spermatids":"2.7","Oocytes":"27.6","Other brain neurons":"4.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"4.5","Oocytes":"27.6","Spermatogenic cell types":"7.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"5.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"26","RNA cell line specific nTPM":{"Rhabdoid":"1.3","testis cancer":"3.7"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"3544","Protein cell type specific Intensity":{"Neurons":"549916.6","Oocytes":"158856.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"55264","Protein tissue specific Intensity":{"cerebral cortex":"5526438.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RTP2","Gene synonym":["MGC78665","Z3CXXC2"],"Ensembl":"ENSG00000198471","Gene description":"Receptor transporter protein 2","Uniprot":["Q5QGT7"],"Chromosome":"3","Position":"187698259-187702557","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"skeletal muscle":"1.9","testis":"1.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"9.8","Epididymal clear cells":"2.0","Late primary spermatocytes":"15.8","Late spermatids":"3.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"15.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"3.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":65,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"RTRAF","Gene synonym":["C14orf166","CGI-99","CLE","CLE7","hCLE1","LCRP369","RLLM1"],"Ensembl":"ENSG00000087302","Gene description":"RNA transcription, translation and transport factor","Uniprot":["Q9Y224"],"Chromosome":"14","Position":"51989514-52010694","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"598.2","Late primary spermatocytes":"1026.9","Late spermatids":"825.2","Oocytes":"842.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"842.7","Spermatogenic cell types":"1026.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":43,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA039824":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.76e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"}},{"Gene":"RUBCNL","Gene synonym":["C13orf18","FLJ21562","KIAA0226L","PACER"],"Ensembl":"ENSG00000102445","Gene description":"Rubicon like autophagy enhancer","Uniprot":["Q9H714"],"Chromosome":"13","Position":"46334681-46438190","Protein class":["Predicted intracellular proteins"],"Biological process":["Autophagy","Lipid metabolism"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"38.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"295.4","Bergmann glia":"146.0","cDC":"123.8","Early spermatids":"181.7","Late spermatids":"182.0","Microglia":"239.5","Neutrophils":"847.2","pDCs":"281.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"295.4","dendritic cells":"281.7","Glial cells":"239.5","Neutrophils":"847.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"Bergmann glia":"147.7","central nervous system macrophage":"318.5"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"43.7","Rectum Adenocarcinoma (TCGA)":"54.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"15","RNA blood cell specific nTPM":{"memory B-cell":"161.8","naive B-cell":"156.3","neutrophil":"124.6","plasmacytoid DC":"106.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"B-cells":"161.8","dendritic cells":"106.4","granulocytes":"124.6"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"lymphoma":"144.9"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA026614":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"RUNX2","Gene synonym":["AML3","CBFA1","CCD","CCD1","PEBP2A1","PEBP2aA1"],"Ensembl":"ENSG00000124813","Gene description":"RUNX family transcription factor 2","Uniprot":["Q13950"],"Chromosome":"6","Position":"45328157-45664349","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"374.3","Innate lymphoid cells":"924.4","Late spermatids":"390.5","Microglia":"449.9","pDCs":"868.3","Salivary duct cells":"518.3","Salivary ionocytes":"723.4","Thymocytes":"695.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"868.3","Innate lymphoid cells":"924.4","Ionocytes":"723.4","T-cells":"695.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"573.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"22.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"29.5"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":32,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB008374":null,"CAB062561":null,"CAB068226":null,"HPA022040":null,"HPA070715":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.38e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.17e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.61e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"}},{"Gene":"RUSC2","Gene synonym":["KIAA0375"],"Ensembl":"ENSG00000198853","Gene description":"RUN and SH3 domain containing 2","Uniprot":["Q8N2Y8"],"Chromosome":"9","Position":"35490111-35561898","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"217.0","Myonuclei":"345.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"345.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"3.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"3.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"73518.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1109","Protein tissue specific Intensity":{"cerebral cortex":"110859.2"},"Antibody":["HPA021297"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021297":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.18e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"}},{"Gene":"RUVBL2","Gene synonym":["ECP51","INO80J","Reptin52","RVB2","TIH2","TIP48","TIP49b"],"Ensembl":"ENSG00000183207","Gene description":"RuvB like AAA ATPase 2","Uniprot":["Q9Y230"],"Chromosome":"19","Position":"48993562-49015970","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair","Growth regulation","Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator","Helicase","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"232.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"588.2","Fallopian tube ciliated cells":"300.7","Late primary spermatocytes":"918.0","Late spermatids":"1436.5","Respiratory ciliated cells":"275.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1436.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"201058061.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"93976728.3"},"Antibody":["CAB012432","HPA042880","HPA067966"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"150000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":356,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Centrosome","Basal body"],"Antibody RRID":{"CAB012432":null,"HPA042880":null,"HPA067966":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.55e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.58e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"}},{"Gene":"RWDD2A","Gene synonym":["dJ747H23.2","MGC13523","RWDD2"],"Ensembl":"ENSG00000013392","Gene description":"RWD domain containing 2A","Uniprot":["Q9UIY3"],"Chromosome":"6","Position":"83193357-83198935","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"33.2","Late primary spermatocytes":"128.8","Prostatic glandular cells":"44.2","Retinal pigment epithelial cells":"25.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glandular cells":"44.2","Spermatogenic cell types":"128.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"16.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA030105":null,"HPA030106":null,"HPA030107":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.27e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.83e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.98e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"}},{"Gene":"RXFP2","Gene synonym":["GPR106","GREAT","INSL3R","LGR8","RXFPR2"],"Ensembl":"ENSG00000133105","Gene description":"Relaxin family peptide receptor 2","Uniprot":["Q8WXD0"],"Chromosome":"13","Position":"31739526-31803389","Protein class":["Disease related genes","G-protein coupled receptors","Potential drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"2.1","Brain inhibitory neurons":"4.7","Cardiomyocytes":"4.3","Early spermatids":"6.6","Late primary spermatocytes":"8.0","Mesothelial cells":"1.3","Monocyte progenitors":"1.8","Other brain neurons":"2.7","Platelets":"2.8","Suprabasal keratinocytes":"1.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"4.3","Neuronal cells":"4.7","Platelets":"2.8","Spermatogenic cell types":"8.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"10.3","deep-layer intratelencephalic":"16.9","hippocampal CA1-3":"10.4","medium spiny neuron":"12.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"classical monocyte":"1.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"monocytes":"1.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"1.0"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":null,"Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"71981.4","Pancreatic islets":"114228.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"8322.9"},"Antibody":["HPA064014"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":6,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA064014":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.67e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.85e-7"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.24e-5"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"}},{"Gene":"SAA2","Gene synonym":[],"Ensembl":"ENSG00000134339","Gene description":"Serum amyloid A2","Uniprot":["P0DJI9"],"Chromosome":"11","Position":"18239223-18248668","Protein class":["Disease related genes","Predicted secreted proteins"],"Biological process":["Acute phase"],"Molecular function":null,"Disease involvement":["Amyloidosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"19","RNA tissue specific nTPM":{"liver":"31118.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Hepatocytes":"15523.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Hepatocytes":"15523.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"19","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"1437.3"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"pons":"17.8","thalamus":"22.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"394.0"},"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Kidney - Macrophages","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"80988","Protein tissue specific Intensity":{"salivary gland":"8098771.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Acute phase","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":50000000,"Blood concentration - Conc. blood MS [pg\/L]":"9900000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.89e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.77e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.69e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":65000000000,"Blood concentration - Conc. blood MS [pg\/L]":"6800000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 53: Liver - Plasma proteins","Brain expression cluster":null,"Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB026061":null,"HPA060139":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":35,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA039003":null,"HPA039004":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"17000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":33,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041906":null,"HPA043552":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"}},{"Gene":"SAG","Gene synonym":["ARRESTIN","RP47"],"Ensembl":"ENSG00000130561","Gene description":"S-antigen visual arrestin","Uniprot":["P10523"],"Chromosome":"2","Position":"233307816-233347055","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Congenital stationary night blindness","Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"353","RNA tissue specific nTPM":{"retina":"1359.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Rod photoreceptor cells":"1864.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Neuronal cells":"1864.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"1.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA004946":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SAMD13","Gene synonym":[],"Ensembl":"ENSG00000203943","Gene description":"Sterile alpha motif domain containing 13","Uniprot":["Q5VXD3"],"Chromosome":"1","Position":"84298366-84389957","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"20.6","salivary gland":"16.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"53.2","Colonocytes":"58.9","Enteric stem cells":"45.3","Enteric transient amplifying cells":"44.1","Late primary spermatocytes":"54.5","Parietal cells":"51.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"53.2","Enterocytes":"58.9","Gastric glandular cells":"51.3","Spermatogenic cell types":"54.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"15","RNA blood cell specific nTPM":{"basophil":"12.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"granulocytes":"12.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA058929":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Nucleoli","Cytosol"],"Antibody RRID":{"HPA030673":null,"HPA030677":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028992":null,"HPA028993":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.34e-4"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":40,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA034664":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"}},{"Gene":"SAP18","Gene synonym":["2HOR0202","MGC27131","SAP18p"],"Ensembl":"ENSG00000150459","Gene description":"Sin3A associated protein 18","Uniprot":["O00422"],"Chromosome":"13","Position":"21140119-21149097","Protein class":["Essential proteins","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA processing","mRNA splicing","Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1229.3","Esophageal apical cells":"1096.6","Late primary spermatocytes":"1512.9","Oocytes":"1358.5","Syncytiotrophoblasts":"1064.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"1358.5","Spermatogenic cell types":"1512.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011352","CAB012273"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":108,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB012273":null,"HPA011352":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.15e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.75e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.17e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"}},{"Gene":"SAR1B","Gene synonym":["SARA2"],"Ensembl":"ENSG00000152700","Gene description":"Secretion associated Ras related GTPase 1B","Uniprot":["Q9Y6B6"],"Chromosome":"5","Position":"134601149-134649271","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Protein transport","Transport"],"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"438.1","Esophageal apical cells":"336.7","Hepatocytes":"334.1","Late primary spermatocytes":"397.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"438.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"16489703.1","Pancreas epithelial cells":"6613848.1","Pancreatic islets":"5681338.1","Proximal tubules":"7082833.6","Skeletal myofibers":"13305629.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"36760284.5"},"Antibody":["HPA006923","HPA048368"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"360000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":146,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA006923":null,"HPA048368":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.15e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.02e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"}},{"Gene":"SAV1","Gene synonym":["salvador","WW45","WWP4"],"Ensembl":"ENSG00000151748","Gene description":"Salvador family WW domain containing protein 1","Uniprot":["Q9H4B6"],"Chromosome":"14","Position":"50632058-50668306","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Platelets":"230.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Endothelial cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"50","Protein cell type specific Intensity":{"Collecting ducts":"3039.9","Fallopian tube cells":"6902.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"76975.0","lymphoid tissue":"43843.5","pancreas":"64520.1"},"Antibody":["HPA001808"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 55: Breast - Lactation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":39,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA001808":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.99e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.07e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.27e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":39,"Subcellular main location":["Flagellar centriole","End piece"],"Subcellular additional location":["Mid piece"],"Antibody RRID":{"HPA023899":null,"HPA076454":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SAXO2","Gene synonym":["DKFZp666G057","FAM154B"],"Ensembl":"ENSG00000188659","Gene description":"Stabilizer of axonemal microtubules 2","Uniprot":["Q658L1"],"Chromosome":"15","Position":"82262810-82284930","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"epididymis":"16.7","fallopian tube":"48.1","testis":"18.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"117.0","Ependymal cells":"120.8","Fallopian tube ciliated cells":"293.4","Late primary spermatocytes":"120.9","Late spermatids":"258.9","Respiratory ciliated cells":"639.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Ciliated cells":"639.3","Spermatogenic cell types":"258.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"139.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Centrosome","Cytosol","Connecting piece"],"Subcellular additional location":["Mid piece"],"Antibody RRID":{"HPA040487":null,"HPA040833":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"}},{"Gene":"SAYSD1","Gene synonym":["C6orf64","FLJ11101"],"Ensembl":"ENSG00000112167","Gene description":"SAYSVFN motif domain containing 1","Uniprot":["Q9NPB0"],"Chromosome":"6","Position":"39104063-39115193","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"30.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"86.4","Early spermatids":"109.4","Late primary spermatocytes":"427.7","Late spermatids":"80.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"427.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028891"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"18000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":41,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA028891":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.82e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.67e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.98e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.53e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"}},{"Gene":"SBF1","Gene synonym":["DENND7A","MTMR5"],"Ensembl":"ENSG00000100241","Gene description":"SET binding factor 1","Uniprot":["O95248"],"Chromosome":"22","Position":"50443219-50483923","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"56453809.7","Microglia and Neuropil":"71154215.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"33847266.8"},"Antibody":["HPA074004"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":21,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA074004":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"}},{"Gene":"SBK2","Gene synonym":["SGK069"],"Ensembl":"ENSG00000187550","Gene description":"SH3 domain binding kinase family member 2","Uniprot":["P0C263"],"Chromosome":"19","Position":"55528611-55537133","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"heart muscle":"122.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"8.6","Epicardial cells":"2.3","Late spermatids":"8.6","Pancreatic islet cells":"3.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"2.3","Pancreatic islet cells":"3.1","Spermatogenic cell types":"8.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"10.6"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030631"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7600","Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA029595":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.47e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"29000","Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":5,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA050775":null,"HPA076030":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.82e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"}},{"Gene":"SCG5","Gene synonym":["7B2","SGNE1","SgV"],"Ensembl":"ENSG00000166922","Gene description":"Secretogranin V","Uniprot":["P05408"],"Chromosome":"15","Position":"32641676-32697098","Protein class":["Predicted secreted proteins"],"Biological process":["Transport"],"Molecular function":["Chaperone","Neuropeptide"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"246.1","choroid plexus":"347.2","pituitary gland":"386.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"124.5","Brain inhibitory neurons":"157.3","Choroid plexus epithelial cells":"37.7","Oligodendrocyte progenitor cells":"69.4","Oligodendrocytes":"89.9","Other brain neurons":"178.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"37.7","Glial cells":"89.9","Neuronal cells":"178.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"82.0","Pancreatic Adenocarcinoma (TCGA)":"181.3","Thyroid Carcinoma (TCGA)":"53.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"thyroid cancer":"101.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"24000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013136":null,"HPA074618":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046806":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5500000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":6,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA020518":null,"HPA024264":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":12,"Subcellular main location":["Basal body","Cytosol"],"Subcellular additional location":["Microtubules"],"Antibody RRID":{"HPA036560":null,"HPA036561":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA063326":null,"HPA065958":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.85e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SCN10A","Gene synonym":["hPN3","Nav1.8","PN3","SNS"],"Ensembl":"ENSG00000185313","Gene description":"Sodium voltage-gated channel alpha subunit 10","Uniprot":["Q9Y5Y9"],"Chromosome":"3","Position":"38696802-38816286","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Sodium transport","Transport"],"Molecular function":["Ion channel","Sodium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"3.2","Epicardial cells":"2.3","Foveolar cells":"2.1","Late primary spermatocytes":"2.3","Late spermatids":"4.6","Retinal amacrine cells":"1.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"2.3","Gastric glandular cells":"2.1","Spermatogenic cell types":"4.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Connecting piece","Flagellar centriole"],"Subcellular additional location":null,"Antibody RRID":{"HPA040337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SCN3A","Gene synonym":["Nav1.3"],"Ensembl":"ENSG00000153253","Gene description":"Sodium voltage-gated channel alpha subunit 3","Uniprot":["Q9NY46"],"Chromosome":"2","Position":"165087526-165204050","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Ion transport","Sodium transport","Transport"],"Molecular function":["Ion channel","Sodium channel","Voltage-gated channel"],"Disease involvement":["Disease variant","Epilepsy","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"8.6","lymphoid tissue":"3.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"255.4","Brain inhibitory neurons":"346.4","Cone photoreceptor cells":"304.3","Corticotrophs":"245.0","Lactotrophs":"218.5","Neuroendocrine cells":"158.6","Oligodendrocyte progenitor cells":"384.6","Other brain neurons":"262.9","Renal collecting duct principal cells":"182.9","Renal connecting tubule cells":"146.9","Somatotrophs":"159.7","Thymocytes":"505.6","Thyrotrophs":"171.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"384.6","Neuronal cells":"346.4","Pituitary endocrine cells":"245.0","T-cells":"505.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"30","RNA blood cell specific nTPM":{"memory B-cell":"13.3","naive B-cell":"15.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"32","RNA blood lineage specific nTPM":{"B-cells":"15.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lung cancer":"9.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035396":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":156,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA052439":null,"HPA054324":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.63e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - 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Fibroblasts","Colon - Enteric glia cells","Spleen - Fibroblasts_2","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"olfactory bulb":"4.6","thalamus":"2.7"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"46281","Protein cell type specific Intensity":{"Fallopian tube cells":"4628126.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006353","HPA029871"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4400000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA006353":null,"HPA029871":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.46e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.90e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.11e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"SDE2","Gene synonym":["C1orf55","FLJ35382"],"Ensembl":"ENSG00000143751","Gene description":"SDE2 telomere maintenance homolog","Uniprot":["Q6IQ49"],"Chromosome":"1","Position":"225982702-225999343","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA replication","Mitosis","mRNA processing","mRNA splicing","Ribosome biogenesis"],"Molecular function":["DNA-binding","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"82.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"756603.0","T-cells":"231253.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"793147.2","lymphoid tissue":"1045641.5","ovary":"876096.8"},"Antibody":["HPA028467","HPA031255","HPA031256"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Golgi apparatus","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":1,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Golgi apparatus","Plasma membrane","Cytosol"],"Antibody RRID":{"HPA028467":null,"HPA031255":null,"HPA031256":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.57e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"}},{"Gene":"SDHAF3","Gene synonym":["ACN9","DC11","LYRM10","Sdh7"],"Ensembl":"ENSG00000196636","Gene description":"Succinate dehydrogenase complex assembly factor 3","Uniprot":["Q9NRP4"],"Chromosome":"7","Position":"97117698-97181763","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"151.7","Megakaryocytes":"160.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"2984703.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020515","HPA020523"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA020515":null,"HPA020523":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"}},{"Gene":"SDHB","Gene synonym":["SDH","SDH1"],"Ensembl":"ENSG00000117118","Gene description":"Succinate dehydrogenase complex iron sulfur subunit B","Uniprot":["P21912"],"Chromosome":"1","Position":"17018722-17054032","Protein class":["Cancer-related genes","Citric acid cycle related proteins","Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Electron transport","Host-virus interaction","Transport","Tricarboxylic acid cycle"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Cancer-related genes","Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"460.5","tongue":"542.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"348.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Spleen - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"450495399.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"159170866.9"},"Antibody":["HPA002868","CAB009822","CAB068233","CAB068234","CAB068235"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":28,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"CAB009822":null,"CAB068233":null,"CAB068234":null,"CAB068235":null,"HPA002868":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.39e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.70e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"}},{"Gene":"SDK1","Gene synonym":["FLJ31425"],"Ensembl":"ENSG00000146555","Gene description":"Sidekick cell adhesion molecule 1","Uniprot":["Q7Z5N4"],"Chromosome":"7","Position":"3301252-4269000","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"11.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial stromal cells":"2278.2","Ependymal cells":"1133.6","Pancreatic islet cells":"1076.1","Pituicytes\/FSCs":"2575.6","Respiratory basal cells":"1787.8","Respiratory ciliated cells":"1091.4","Respiratory deuterosomal cells":"1462.7","Respiratory secretory cells":"2023.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"1787.8","Glial cells":"2575.6","Secretory cells":"2023.2","Stromal cells":"2278.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"1871.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Skin - Fibroblasts_2","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"257889614.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"33598573.2"},"Antibody":["HPA011392"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3500000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA011392":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.80e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"SDK2","Gene synonym":["FLJ10832","KIAA1514"],"Ensembl":"ENSG00000069188","Gene description":"Sidekick cell adhesion molecule 2","Uniprot":["Q58EX2"],"Chromosome":"17","Position":"73334384-73644445","Protein class":["Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"5.2","testis":"9.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"156.1","Extravillous trophoblasts":"149.2","Neuroendocrine cells":"102.6","Retinal bipolar cells":"93.1","Retinal horizontal cells":"146.2","Sertoli cells":"221.2","Syncytiotrophoblasts":"86.9","Thymocytes":"103.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"156.1","Neuronal cells":"146.2","Reproductive supporting cells":"221.2","Trophoblast cells":"149.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"217.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"5.7","testis cancer":"6.6"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Breast - Breast myoepithelial cells","Colon - Enteric glia cells","Liver - Hepatic stellate cells","Minor Salivary Gland - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2251955.3","Fallopian tube cells":"2352072.9","Granulosa cells":"7708045.9","Microglia and Neuropil":"2783129.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"17414562.6","ovary":"34600287.9"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1700000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"}},{"Gene":"SDR42E2","Gene synonym":[],"Ensembl":"ENSG00000183921","Gene description":"Short chain dehydrogenase\/reductase family 42E, member 2","Uniprot":["A6NKP2"],"Chromosome":"16","Position":"22162492-22192208","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Ependymal cells":"56.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Ciliated cells":"56.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"ependymal cell":"58.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"neutrophil":"5.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"5.3"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"43","Protein tissue specific Intensity":{"fallopian tube":"4299.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SEC14L1","Gene synonym":["PRELID4A","SEC14L"],"Ensembl":"ENSG00000129657","Gene description":"SEC14 like lipid binding 1","Uniprot":["Q92503"],"Chromosome":"17","Position":"77088749-77217101","Protein class":["Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Immunity","Innate immunity"],"Molecular function":["Signal transduction inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"799.4","Endometrial glandular cells":"529.1","Late spermatids":"1361.1","Neutrophils":"1193.8","Platelets":"851.3","Vascular endothelial cells":"450.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1193.8","Platelets":"851.3","Secretory cells":"799.4","Spermatogenic cell types":"1361.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"552.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"neutrophil":"356.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"granulocytes":"356.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":4,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021463":null,"HPA028703":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.58e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-3"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3926","Protein cell type specific Intensity":{"Neurons":"392590.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"17305","Protein tissue specific Intensity":{"salivary gland":"1730466.2"},"Antibody":["HPA039127"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":94,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA039127":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.83e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"}},{"Gene":"SEC23B","Gene synonym":["CDA-II","CDAII","CDAN2","HEMPAS"],"Ensembl":"ENSG00000101310","Gene description":"SEC23 homolog B, COPII coat complex component","Uniprot":["Q15437"],"Chromosome":"20","Position":"18507520-18561415","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Congenital dyserythropoietic anemia","Disease variant","Hereditary hemolytic anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"186.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Macrophages","Breast - Breast glandular cells","Colon - Macrophages","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"116776001.3","Pancreatic islets":"42892572.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008216","HPA069974"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5400","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":43,"Subcellular main location":["Endoplasmic reticulum","Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008216":null,"HPA069974":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.93e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"}},{"Gene":"SECISBP2","Gene synonym":["SBP2"],"Ensembl":"ENSG00000187742","Gene description":"SECIS binding protein 2","Uniprot":["Q96T21"],"Chromosome":"9","Position":"89318500-89359663","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"459.8","Late spermatids":"697.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"697.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"1259190.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"21","Protein tissue specific Intensity":{"lymphoid tissue":"2095.5"},"Antibody":["HPA044314","HPA054905"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044314":null,"HPA054905":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.56e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.05e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-1"}},{"Gene":"SEL1L2","Gene synonym":["C20orf50","DKFZp434C1826"],"Ensembl":"ENSG00000101251","Gene description":"SEL1L2 adaptor subunit of ERAD E3 ligase","Uniprot":["Q5TEA6"],"Chromosome":"20","Position":"13849247-13996443","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"40","RNA tissue specific nTPM":{"testis":"6.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"118.2","Early primary spermatocytes":"28.3","Early spermatids":"190.5","Epicardial cells":"50.0","Late primary spermatocytes":"196.1","Late spermatids":"240.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"50.0","Myocytes":"118.2","Spermatogenic cell types":"240.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059121":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SELENOS","Gene synonym":["AD-015","MGC2553","SBBI8","SELS","SEPS1","VIMP"],"Ensembl":"ENSG00000131871","Gene description":"Selenoprotein S","Uniprot":["Q9BQE4"],"Chromosome":"15","Position":"101270817-101277500","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Plasma cells":"627.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"plasmacytoid DC":"608.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"608.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":16,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA010025":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.06e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.45e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"}},{"Gene":"SEM1","Gene synonym":["C7orf76","DSS1","ECD","FLJ42280","PSMD15","SHFD1","Shfdg1","SHFM1","SHSF1"],"Ensembl":"ENSG00000127922","Gene description":"SEM1 26S proteasome subunit","Uniprot":["P60896","Q6ZVN7"],"Chromosome":"7","Position":"96481626-96709880","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"904.3","Syncytiotrophoblasts":"1051.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"}},{"Gene":"SEMG2","Gene synonym":["SGII"],"Ensembl":"ENSG00000124157","Gene description":"Semenogelin 2","Uniprot":["Q02383"],"Chromosome":"20","Position":"45221373-45224458","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"163","RNA tissue specific nTPM":{"seminal vesicle":"9810.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1.4","Late spermatids":"5.2","Papillary tip epithelial cells":"1.1","Prostatic club cells":"1.4","Renal collecting duct principal cells":"2.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"2.1","Glandular cells":"1.4","Renal nephron cells":"1.1","Spermatogenic cell types":"5.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"28","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"16.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"792181936.6"},"Antibody":["HPA042767","HPA042835"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1900000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042767":null,"HPA042835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SENP1","Gene synonym":[],"Ensembl":"ENSG00000079387","Gene description":"SUMO specific peptidase 1","Uniprot":["Q9P0U3"],"Chromosome":"12","Position":"48042897-48106079","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"salivary gland":"30.5","testis":"57.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"119.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"119.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":21,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Focal adhesion sites"],"Antibody RRID":{"HPA011765":null,"HPA046491":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.89e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.85e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"}},{"Gene":"SENP2","Gene synonym":["AXAM2","DKFZp762A2316","KIAA1331","SMT3IP2"],"Ensembl":"ENSG00000163904","Gene description":"SUMO specific peptidase 2","Uniprot":["Q9HC62"],"Chromosome":"3","Position":"185582496-185633551","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["mRNA transport","Protein transport","Translocation","Transport","Ubl conjugation pathway","Wnt signaling pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"274.9","Late primary spermatocytes":"226.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"274.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":41,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA029247":null,"HPA029248":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.41e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.92e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.62e-4"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"}},{"Gene":"SENP8","Gene synonym":["DEN1","HsT17512","NEDP1","PRSC2"],"Ensembl":"ENSG00000166192","Gene description":"SUMO peptidase family member, NEDD8 specific","Uniprot":["Q96LD8"],"Chromosome":"15","Position":"72114258-72143692","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"14.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"210.3","Early spermatids":"122.9","Epicardial cells":"106.9","Late spermatids":"450.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"106.9","Myocytes":"210.3","Spermatogenic cell types":"450.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":7,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA036273":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.47e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.47e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.40e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"}},{"Gene":"SEPTIN10","Gene synonym":["FLJ11619","SEPT10"],"Ensembl":"ENSG00000186522","Gene description":"Septin 10","Uniprot":["Q9P0V9"],"Chromosome":"2","Position":"109542799-109614143","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"342.9","Esophageal apical cells":"479.9","Late spermatids":"668.4","Urothelial cells":"288.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"479.9","Spermatogenic cell types":"668.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"242.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"3.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":24,"Subcellular main location":["Actin filaments"],"Subcellular additional location":["Microtubules","Annulus"],"Antibody RRID":{"HPA056304":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.58e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"}},{"Gene":"SEPTIN12","Gene synonym":["FLJ25410","SEPT12"],"Ensembl":"ENSG00000140623","Gene description":"Septin 12","Uniprot":["Q8IYM1"],"Chromosome":"16","Position":"4777606-4788398","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"37","RNA tissue specific nTPM":{"testis":"103.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Early spermatids":"315.5","Late primary spermatocytes":"468.3","Late spermatids":"155.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"138","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"468.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":13,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Annulus"],"Antibody RRID":{"HPA041128":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":12,"Subcellular main location":["Annulus"],"Subcellular additional location":null,"Antibody RRID":{"CAB006855":null,"HPA021587":null,"HPA022905":null,"HPA028424":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.76e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"}},{"Gene":"SERAC1","Gene synonym":["FLJ14917"],"Ensembl":"ENSG00000122335","Gene description":"Serine active site containing 1","Uniprot":["Q96JX3"],"Chromosome":"6","Position":"158109519-158168280","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism","Phospholipid biosynthesis","Phospholipid metabolism"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"104.5","Late spermatids":"162.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"162.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA025715":null,"HPA025716":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.14e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.15e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"}},{"Gene":"SERBP1","Gene synonym":["CGI-55","CHD3IP","DKFZP564M2423","HABP4L","PAI-RBP1","PAIRBP1"],"Ensembl":"ENSG00000142864","Gene description":"SERPINE1 mRNA binding protein 1","Uniprot":["Q8NC51"],"Chromosome":"1","Position":"67407810-67430415","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Translation regulation"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020559","CAB026297"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"380000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":208,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB026297":null,"HPA020559":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.64e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.83e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.80e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.89e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.61e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"}},{"Gene":"SERINC3","Gene synonym":["AIGP1","DIFF33","SBBI99","TDE","TDE1","TMS-1"],"Ensembl":"ENSG00000132824","Gene description":"Serine incorporator 3","Uniprot":["Q13530"],"Chromosome":"20","Position":"44496221-44522085","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Antiviral defense","Host-virus interaction","Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"970.1","Neutrophils":"766.7","Platelets":"373.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"766.7","Spermatogenic cell types":"970.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"85","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"8486.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA048116"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048116":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-7"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.65e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.71e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.91e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"}},{"Gene":"SERPINB11","Gene synonym":[],"Ensembl":"ENSG00000206072","Gene description":"Serpin family B member 11","Uniprot":["Q96P15"],"Chromosome":"18","Position":"63647579-63726432","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Serine protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"25.7","prostate":"30.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"656.3","Esophageal apical cells":"205.5","Esophageal suprabasal cells":"55.8","Prostatic club cells":"150.9","Prostatic glandular cells":"72.4","Prostatic hillock cells":"62.4","Respiratory basal cells":"62.4","Respiratory deuterosomal cells":"64.3","Respiratory secretory cells":"214.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"205.5","Glandular cells":"150.9","Goblet cells":"656.3","Secretory cells":"214.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"19.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"1.2"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"cerebral cortex":"1.5"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"}},{"Gene":"SERPINB6","Gene synonym":["CAP","DFNB91","PI6","PTI"],"Ensembl":"ENSG00000124570","Gene description":"Serpin family B member 6","Uniprot":["P35237"],"Chromosome":"6","Position":"2948159-2972165","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Serine protease inhibitor"],"Disease involvement":["Deafness","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"595.7","Esophageal apical cells":"981.9","Late primary spermatocytes":"595.8","Late spermatids":"1570.5","Pancreatic acinar cells":"691.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"981.9","Spermatogenic cell types":"1570.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"428.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Vascular endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"181527648.0"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA009668","HPA012736"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3100000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA009668":null,"HPA012736":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.78e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.98e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"}},{"Gene":"SESN3","Gene synonym":["MGC29667","SEST3"],"Ensembl":"ENSG00000149212","Gene description":"Sestrin 3","Uniprot":["P58005"],"Chromosome":"11","Position":"95165513-95232541","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"54.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"346.9","Early spermatids":"803.7","Late primary spermatocytes":"363.7","Late spermatids":"825.6","Retinal pigment epithelial cells":"456.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pigment cells":"456.1","Spermatogenic cell types":"825.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"702.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"testis cancer":"102.2"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"397880.4","Neurons":"347376.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1227105.9","lymphoid tissue":"927451.9"},"Antibody":["HPA037935"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037935":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"}},{"Gene":"SETD3","Gene synonym":["C14orf154","FLJ23027"],"Ensembl":"ENSG00000183576","Gene description":"SET domain containing 3, actin histidine methyltransferase","Uniprot":["Q86TU7"],"Chromosome":"14","Position":"99397748-99480889","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding","Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"311.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Spleen - Endothelial cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"23649417.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA003591","HPA003639"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA003591":null,"HPA003639":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.68e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA024073":null,"HPA035405":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"}},{"Gene":"SETD9","Gene synonym":["C5orf35","MGC33648"],"Ensembl":"ENSG00000155542","Gene description":"SET domain containing 9","Uniprot":["Q8NE22"],"Chromosome":"5","Position":"56909260-56925532","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"17.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"754.2","Late primary spermatocytes":"414.9","Late spermatids":"482.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"754.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"5.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"5.2","monocytes":"3.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA049936":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.05e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"}},{"Gene":"SEZ6L","Gene synonym":[],"Ensembl":"ENSG00000100095","Gene description":"Seizure related 6 homolog like","Uniprot":["Q9BYH1"],"Chromosome":"22","Position":"26169462-26383597","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"46.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"202.1","Brain excitatory neurons":"324.8","Brain inhibitory neurons":"170.8","Corticotrophs":"92.8","Gonadotrophs":"212.8","Oligodendrocyte progenitor cells":"849.9","Other brain neurons":"238.2","Pancreatic islet cells":"183.2","Retinal amacrine cells":"170.0","Retinal horizontal cells":"122.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"202.1","Glial cells":"849.9","Neuronal cells":"324.8","Pancreatic islet cells":"183.2","Pituitary endocrine cells":"212.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"26.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"intermediate monocyte":"5.9","myeloid DC":"5.7","non-classical monocyte":"5.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"58","RNA blood lineage specific nTPM":{"dendritic cells":"5.7","monocytes":"5.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bone cancer":"23.7","lung cancer":"8.1","Neuroblastoma":"23.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1500000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA045135":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"SF3A1","Gene synonym":["Prp21","PRPF21","SAP114","SF3a120"],"Ensembl":"ENSG00000099995","Gene description":"Splicing factor 3a subunit 1","Uniprot":["Q15459"],"Chromosome":"22","Position":"30331988-30356919","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"179.7","Neutrophils":"132.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"179.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA000690","HPA030083"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"28000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":299,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA000690":null,"HPA030083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.12e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.01e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.79e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"}},{"Gene":"SFMBT1","Gene synonym":["DKFZp434L243","RU1","SFMBT"],"Ensembl":"ENSG00000163935","Gene description":"Scm like with four mbt domains 1","Uniprot":["Q9UHJ3"],"Chromosome":"3","Position":"52903572-53046750","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"42.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"208.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"208.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"8561","Protein cell type specific Intensity":{"B-cells":"1614536.4","Granulosa cells":"455659.1","Neurons":"498100.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036152","HPA064564"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA036152":null,"HPA064564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.69e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.28e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"}},{"Gene":"SFXN4","Gene synonym":["SLC56A4"],"Ensembl":"ENSG00000183605","Gene description":"Sideroflexin 4","Uniprot":["Q6P4A7"],"Chromosome":"10","Position":"119140767-119165714","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Transport"],"Molecular function":null,"Disease involvement":["Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"128.4","Myonuclei":"193.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"193.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"95046686.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"18412087.1"},"Antibody":["HPA018028","HPA020872"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":33,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA018028":null,"HPA020872":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.90e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.38e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"}},{"Gene":"SGMS2","Gene synonym":["MGC26963","SMS2"],"Ensembl":"ENSG00000164023","Gene description":"Sphingomyelin synthase 2","Uniprot":["Q8NHU3"],"Chromosome":"4","Position":"107824563-107915047","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism","Sphingolipid metabolism"],"Molecular function":["Kinase","Transferase"],"Disease involvement":["Disease variant","Osteoporosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"511.5","Alveolar cells type 2":"1224.2","Endometrial ciliated cells":"1037.7","Endometrial glandular cells":"1004.0","Endometrial luminal cells":"788.7","Endometrial secretory cells":"539.3","Transitional alveolar cells":"857.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"1224.2","Ciliated cells":"1037.7","Glandular cells":"1004.0","Luminal cells":"788.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"214.4","ependymal cell":"211.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"classical monocyte":"3.7","eosinophil":"2.4","intermediate monocyte":"1.5","myeloid DC":"4.2","non-classical monocyte":"1.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"35","RNA blood lineage specific nTPM":{"dendritic cells":"4.2","granulocytes":"2.4","monocytes":"3.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":3,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA015076":null,"HPA015541":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.58e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.30e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"SGO2","Gene synonym":["FLJ25211","SGOL2","TRIPIN"],"Ensembl":"ENSG00000163535","Gene description":"Shugoshin 2","Uniprot":["Q562F6"],"Chromosome":"2","Position":"200510008-200584096","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Chromosome partition","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"13.9","testis":"30.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"80.0","Early primary spermatocytes":"267.6","Erythrocyte progenitors":"70.5","Late primary spermatocytes":"327.9","Megakaryocyte progenitors":"72.5","Mesothelial cells":"169.6","Monocyte progenitors":"153.6","Oocytes":"101.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"169.6","Mononuclear phagocytes":"153.6","Spermatogenic cell types":"327.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"16.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"16.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2478","Protein cell type specific Intensity":{"T-cells":"247808.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"120","Protein tissue specific Intensity":{"intestine":"12034.9"},"Antibody":["HPA035163","HPA040817"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA035163":null,"HPA040817":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.68e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.02e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.88e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.97e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"}},{"Gene":"SH2B3","Gene synonym":["IDDM20","LNK"],"Ensembl":"ENSG00000111252","Gene description":"SH2B adaptor protein 3","Uniprot":["Q9UQQ2"],"Chromosome":"12","Position":"111405923-111451623","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes","Diabetes mellitus"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"57.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"297.9","Kupffer cells":"256.2","Macrophages":"272.9","Mast cells":"120.8","Microglia":"153.7","Monocyte progenitors":"123.2","monocytes":"274.7","pDCs":"363.8","Platelets":"145.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"363.8","Mononuclear phagocytes":"274.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"193.8","leukocyte":"103.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Kidney - Endothelial cells","Lung - Endothelial cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"3623","Protein cell type specific Intensity":{"Capillaries":"362339.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"38","Protein tissue specific Intensity":{"lymphoid tissue":"3750.1"},"Antibody":["HPA005483"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 6: Plasmacytoid dendritic cells - Viral sensing & interferon response","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA005483":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"SH2D5","Gene synonym":[],"Ensembl":"ENSG00000189410","Gene description":"SH2 domain containing 5","Uniprot":["Q6ZV89"],"Chromosome":"1","Position":"20719731-20732837","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"16.8","testis":"6.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"3.9","Brain excitatory neurons":"7.3","Brain inhibitory neurons":"13.8","Epicardial cells":"4.5","Other brain neurons":"6.3","Retinal amacrine cells":"3.4","Syncytiotrophoblasts":"7.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"4.5","Basal cells":"3.9","Neuronal cells":"13.8","Trophoblast cells":"7.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"6.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"9239","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"755817.1","Microglia and Neuropil":"909913.9","Neurons":"1105991.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"13431","Protein tissue specific Intensity":{"cerebral cortex":"1343080.2"},"Antibody":["HPA030182"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA030182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SH2D7","Gene synonym":["LOC646892"],"Ensembl":"ENSG00000183476","Gene description":"SH2 domain containing 7","Uniprot":["A6NKC9"],"Chromosome":"15","Position":"78077808-78104370","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"intestine":"2.2","testis":"2.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"242.8","Late primary spermatocytes":"393.2","Late spermatids":"224.9","Tuft cells":"1003.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"208","RNA single cell type group specific nCPM":{"Secretory gland support":"1003.0","Spermatogenic cell types":"393.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"1.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051320","HPA058382","HPA076728"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA051320":null,"HPA058382":null,"HPA076728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"}},{"Gene":"SH3BGR","Gene synonym":["21-GARP"],"Ensembl":"ENSG00000185437","Gene description":"SH3 domain binding glutamate rich protein","Uniprot":["P55822"],"Chromosome":"21","Position":"39445855-39515506","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skeletal muscle":"1188.4","tongue":"573.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"28.7","Bergmann glia":"15.3","Brain excitatory neurons":"9.1","Brain inhibitory neurons":"11.9","Choroid plexus epithelial cells":"24.1","Distal convoluted tubule cells":"15.1","Ependymal cells":"38.1","Loop of henle epithelial cells":"11.3","Oligodendrocyte progenitor cells":"11.0","Oligodendrocytes":"24.7","Other brain neurons":"9.0","Podocytes":"9.0","Proximal tubule cells":"8.4","Renal collecting duct principal cells":"7.4","Renal connecting tubule cells":"11.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"38.1","Ductal cells":"11.5","Glial cells":"28.7","Neuronal cells":"11.9","Renal nephron cells":"15.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"56.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"3.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast myoepithelial cells","Lung - Smooth muscle cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"cerebellum":"30.5","midbrain":"12.2","olfactory bulb":"9.9","pons and medulla":"31.9"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"46908300.3","Skeletal myofibers":"121468378.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"158958781.2","skeletal muscle":"457982957.6"},"Antibody":["CAB003685"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7700","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":1,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB003685":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.41e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"}},{"Gene":"SH3GL3","Gene synonym":["CNSA3","EEN-B2","HsT19371","SH3D2C","SH3P13"],"Ensembl":"ENSG00000140600","Gene description":"SH3 domain containing GRB2 like 3, endophilin A3","Uniprot":["Q99963"],"Chromosome":"15","Position":"83447228-83618743","Protein class":["Predicted intracellular proteins"],"Biological process":["Endocytosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"56.9","testis":"24.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"268.4","Brain inhibitory neurons":"285.3","Early spermatids":"803.5","Ependymal cells":"205.6","Late primary spermatocytes":"249.4","Late spermatids":"2395.6","Loop of henle epithelial cells":"328.4","Oligodendrocytes":"1310.9","Retinal horizontal cells":"538.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1310.9","Neuronal cells":"538.9","Spermatogenic cell types":"2395.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"1662.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"14.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA039381":null,"HPA077877":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SH3GLB1","Gene synonym":["Bif-1","CGI-61","KIAA0491","PPP1R70"],"Ensembl":"ENSG00000097033","Gene description":"SH3 domain containing GRB2 like, endophilin B1","Uniprot":["Q9Y371"],"Chromosome":"1","Position":"86704570-86748184","Protein class":["Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Apoptosis","Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"578.0","Esophageal apical cells":"1111.7","Late primary spermatocytes":"954.3","Neutrophils":"1166.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1111.7","Neutrophils":"1166.1","Spermatogenic cell types":"954.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"302.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004650","HPA015608","HPA019900"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":129,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB004650":null,"HPA015608":null,"HPA019900":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.47e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.54e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.70e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"SH3YL1","Gene synonym":["DKFZP586F1318","Ray"],"Ensembl":"ENSG00000035115","Gene description":"SH3 and SYLF domain containing 1","Uniprot":["Q96HL8"],"Chromosome":"2","Position":"217730-266398","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"437.9","Esophageal apical cells":"542.4","Parietal cells":"512.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"542.4","Gastric glandular cells":"512.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA030926":null,"HPA030927":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.11e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"}},{"Gene":"SHARPIN","Gene synonym":["DKFZP434N1923","SIPL1"],"Ensembl":"ENSG00000179526","Gene description":"SHANK associated RH domain interactor","Uniprot":["Q9H0F6"],"Chromosome":"8","Position":"144098633-144108124","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"2267.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2267.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":55,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA024825":null,"HPA044453":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.31e-4"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.91e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"}},{"Gene":"SHCBP1L","Gene synonym":["C1orf14"],"Ensembl":"ENSG00000157060","Gene description":"SHC binding and spindle associated 1 like","Uniprot":["Q9BZQ2"],"Chromosome":"1","Position":"182899865-182953525","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"1072","RNA tissue specific nTPM":{"testis":"107.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"13","RNA single cell type specific nCPM":{"Early primary spermatocytes":"510.7","Early spermatids":"653.8","Late primary spermatocytes":"1240.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"175","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1240.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036124","HPA036125","HPA064821"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036124":null,"HPA036125":null,"HPA064821":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SHE","Gene synonym":[],"Ensembl":"ENSG00000169291","Gene description":"Src homology 2 domain containing E","Uniprot":["Q5VZ18"],"Chromosome":"1","Position":"154469772-154502412","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"24.3","Alveolar cells type 2":"24.3","Differentiating spermatogonia":"24.2","Early primary spermatocytes":"28.4","Epicardial cells":"40.9","Kupffer cells":"74.8","Late primary spermatocytes":"33.3","Late spermatids":"34.9","Lymphatic endothelial cells":"94.6","Sertoli cells":"52.7","Thymic myoid cells":"36.7","Undifferentiated spermatogonia":"26.8","Vascular endothelial cells":"115.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"40.9","Endothelial cells":"115.5","Mononuclear phagocytes":"74.8","Reproductive supporting cells":"52.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"endothelial cell":"159.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"26.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA037417":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"}},{"Gene":"SHH","Gene synonym":["HHG1","HLP3","HPE3","MCOPCB5","SMMCI","TPT","TPTPS"],"Ensembl":"ENSG00000164690","Gene description":"Sonic hedgehog signaling molecule","Uniprot":["Q15465"],"Chromosome":"7","Position":"155799980-155812463","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Developmental protein","Hydrolase","Protease","Transferase"],"Disease involvement":["Disease variant","Holoprosencephaly","Microphthalmia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"8.2","liver":"12.5","stomach 1":"9.9","urinary bladder":"15.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"16.2","Basal prostatic cells":"18.0","Cholangiocytes":"14.6","Endometrial secretory cells":"16.2","Epididymal efferent duct absorptive cells":"21.4","Foveolar cells":"41.6","Hepatocytes":"25.0","Papillary tip epithelial cells":"25.7","Prostatic hillock cells":"46.6","Urothelial cells":"59.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"59.1","Gastric glandular cells":"41.6","Hepatocytes":"25.0","Renal nephron cells":"25.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"mammillary body":"31.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"13.5"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Lung - Alveolar cells type 2","Pituitary gland - Gonadotropes","Skin - Inner root sheath cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"760000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.89e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-3"}},{"Gene":"SHISA7","Gene synonym":[],"Ensembl":"ENSG00000187902","Gene description":"Shisa family member 7","Uniprot":["A6NL88"],"Chromosome":"19","Position":"55428740-55443300","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"24.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"24.6","Brain inhibitory neurons":"37.6","Oligodendrocyte progenitor cells":"57.5","Oligodendrocytes":"24.7","Other brain neurons":"20.6","Retinal amacrine cells":"12.0","Somatotrophs":"9.8","Thyrotrophs":"6.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"57.5","Neuronal cells":"37.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"12","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"1.7","Neuroblastoma":"2.0"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Pituitary gland - Somatotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"9264","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"835468.4","Microglia and Neuropil":"1466012.6","Neurons":"477688.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"120213","Protein tissue specific Intensity":{"cerebral cortex":"12021320.5"},"Antibody":["HPA058935"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA058935":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SHMT1","Gene synonym":["cSHMT","MGC15229","MGC24556","SHMT"],"Ensembl":"ENSG00000176974","Gene description":"Serine hydroxymethyltransferase 1","Uniprot":["P34896"],"Chromosome":"17","Position":"18327860-18363563","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["One-carbon metabolism"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"156.8","liver":"375.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Proximal tubule cells":"220.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Renal nephron cells":"220.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"47.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"88.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Colon - Macrophages","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Liver - Hepatocytes","Pituitary gland - Undifferentiated cells (Pituitary gland)","Spleen - Macrophages","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"339250888.4","Hepatocytes":"409593303.1","Proximal tubules":"716123317.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"803832634.2"},"Antibody":["HPA023314","HPA078682"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1900000","Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":10,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023314":null,"HPA078682":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.26e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.74e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - 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Adrenal cortex cells","Kidney - Intercalated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"693681.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2777","Protein tissue specific Intensity":{"intestine":"277705.6"},"Antibody":["HPA052214"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA052214":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SHOX2","Gene synonym":["OG12","OG12X","SHOT"],"Ensembl":"ENSG00000168779","Gene description":"Short stature homeobox 2","Uniprot":["O60902"],"Chromosome":"3","Position":"158095905-158106420","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"5.4","blood vessel":"10.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"128.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"128.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"thalamic excitatory":"59.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"6.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"thalamus":"44.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SI","Gene synonym":[],"Ensembl":"ENSG00000090402","Gene description":"Sucrase-isomaltase","Uniprot":["P14410"],"Chromosome":"3","Position":"164978898-165078496","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosidase","Hydrolase","Multifunctional enzyme"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"150","RNA tissue specific nTPM":{"intestine":"513.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Enterocytes":"1438.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Enterocytes":"1438.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Stomach Adenocarcinoma (TCGA)":"9.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"1.2","prostate cancer":"1.7"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA011897":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SIAH1","Gene synonym":["hSIAH1"],"Ensembl":"ENSG00000196470","Gene description":"Siah E3 ubiquitin protein ligase 1","Uniprot":["Q8IUQ4"],"Chromosome":"16","Position":"48356364-48448402","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Apoptosis","Cell cycle","Differentiation","Spermatogenesis","Ubl conjugation pathway"],"Molecular function":["Developmental protein","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"301.7","Early spermatids":"286.6","Syncytiotrophoblasts":"1086.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"286.6","Trophoblast cells":"1086.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"21","Protein cell type specific Intensity":{"Granulosa cells":"2090.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB018724"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":161,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB018724":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.41e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"}},{"Gene":"SIDT1","Gene synonym":["FLJ20174","SID-1"],"Ensembl":"ENSG00000072858","Gene description":"SID1 transmembrane family member 1","Uniprot":["Q9NXL6"],"Chromosome":"3","Position":"113532555-113629575","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"10.6","salivary gland":"10.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"138.3","B-cells":"179.0","Brain excitatory neurons":"132.5","Goblet cells":"217.4","Neuroendocrine cells":"147.5","NK-cells":"189.6","Somatotrophs":"131.3","T-cells":"134.0","Thymocytes":"138.9","Thyrotrophs":"209.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"12.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"33.7"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"6.2","Myeloma":"7.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035862":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"SIGLEC15","Gene synonym":["CD33L3","HsT1361"],"Ensembl":"ENSG00000197046","Gene description":"Sialic acid binding Ig like lectin 15","Uniprot":["Q6ZMC9"],"Chromosome":"18","Position":"45825675-45844094","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"breast":"1.6","intestine":"2.8","urinary bladder":"1.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"6.6","Cardiomyocytes":"3.3","Endometrial secretory cells":"3.2","Epicardial cells":"4.5","Fallopian tube ciliated cells":"3.3","Hofbauer cells":"18.2","Parietal cells":"12.4","Urothelial cells":"5.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"12.4","Luminal cells":"6.6","Mononuclear phagocytes":"18.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"classical monocyte":"3.0","myeloid DC":"1.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"21","RNA blood lineage specific nTPM":{"dendritic cells":"1.0","monocytes":"3.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Brain cancer":"11.3","thyroid cancer":"12.9"},"RNA tissue cell type enrichment":["Liver - Hepatocytes","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053509"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA053509":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-1"}},{"Gene":"SIGLECL1","Gene synonym":["C19orf75","FLJ40235","SIGLEC23P","SIGLECP7"],"Ensembl":"ENSG00000179213","Gene description":"SIGLEC family like 1","Uniprot":["Q8N7X8"],"Chromosome":"19","Position":"51246348-51269330","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"66","RNA tissue specific nTPM":{"testis":"19.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"40.0","Early spermatids":"34.1","Late primary spermatocytes":"140.6","Late spermatids":"121.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"70","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"140.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"1.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":22,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA079471":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SIK3","Gene synonym":["FLJ12240","KIAA0999","L19","QSK"],"Ensembl":"ENSG00000160584","Gene description":"SIK family kinase 3","Uniprot":["Q9Y2K2"],"Chromosome":"11","Position":"116843402-117098437","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Dwarfism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial luminal cells":"2137.8","Neutrophils":"3412.0","Oligodendrocytes":"2587.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"3412.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2857.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Undifferentiated cells (Pituitary gland)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3429628.3"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"5506599.8"},"Antibody":["HPA045245","HPA048161"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045245":null,"HPA048161":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.27e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.98e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"}},{"Gene":"SIL1","Gene synonym":["BAP","MSS","ULG5"],"Ensembl":"ENSG00000120725","Gene description":"SIL1 nucleotide exchange factor","Uniprot":["Q9H173"],"Chromosome":"5","Position":"138946724-139293557","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"2696683.9","Pancreatic islets":"4657555.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"1941024.4"},"Antibody":["HPA011949"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Transport","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"770000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":25,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA011949":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.99e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"}},{"Gene":"SIM1","Gene synonym":["bHLHe14"],"Ensembl":"ENSG00000112246","Gene description":"SIM bHLH transcription factor 1","Uniprot":["P81133"],"Chromosome":"6","Position":"100385009-100464921","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"2.7","kidney":"9.2","skeletal muscle":"3.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"372.1","Epididymal basal cells":"51.8","Epididymal efferent duct absorptive cells":"63.9","Loop of henle epithelial cells":"285.8","Pancreatic islet cells":"92.9","Papillary tip epithelial cells":"68.4","Renal collecting duct intercalated cells":"265.8","Renal collecting duct principal cells":"160.3","Renal connecting tubule cells":"245.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"265.8","Pancreatic islet cells":"92.9","Renal nephron cells":"372.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"mammillary body":"89.4"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"10.7","Kidney Renal Papillary Cell Carcinoma (TCGA)":"3.3"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"hypothalamus":"9.2","midbrain":"2.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"2.3","ovarian cancer":"1.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"8","RNA mouse brain regional specific nTPM":{"hypothalamus":"5.2"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024385"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":5,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA024385":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SIMC1","Gene synonym":["C5orf25","FLJ44216","OOMA1","PLEIAD"],"Ensembl":"ENSG00000170085","Gene description":"SUMO interacting motifs containing 1","Uniprot":["Q8NDZ2"],"Chromosome":"5","Position":"176238367-176345991","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"38.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"291.0","Sertoli cells":"185.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"291.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA037889":null,"HPA037890":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"}},{"Gene":"SINHCAF","Gene synonym":["C12orf14","FAM60A","TERA"],"Ensembl":"ENSG00000139146","Gene description":"SIN3-HDAC complex associated factor","Uniprot":["Q9NP50"],"Chromosome":"12","Position":"31280584-31327058","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"170.1","Early spermatids":"158.7","Epididymal basal cells":"107.5","Fallopian secretory cells":"115.3","Fallopian tube ciliated cells":"113.8","Renal collecting duct intercalated cells":"128.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"170.1","Spermatogenic cell types":"158.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"75.9","choroid plexus epithelial cell":"117.3","leukocyte":"53.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":53,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA038167":null,"HPA057585":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.93e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"}},{"Gene":"SIRPB1","Gene synonym":["CD172b","SIRP-BETA-1"],"Ensembl":"ENSG00000101307","Gene description":"Signal regulatory protein beta 1","Uniprot":["O00241","Q5TFQ8"],"Chromosome":"20","Position":"1561385-1620061","Protein class":["CD markers","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"49.3","lung":"18.3","lymphoid tissue":"27.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Kupffer cells":"1.0","monocytes":"2.3","Neutrophil progenitors":"3.9","Neutrophils":"11.2","pDCs":"1.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"11.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1606.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"1606.1","monocytes":"503.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"18.6","thyroid cancer":"23.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4700000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":4,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA047463":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 39: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":225,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center","Mitochondria","Cytosol"],"Antibody RRID":{"CAB003855":null,"HPA006295":null,"HPA052351":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"SIRT4","Gene synonym":["SIR2L4"],"Ensembl":"ENSG00000089163","Gene description":"Sirtuin 4","Uniprot":["Q9Y6E7"],"Chromosome":"12","Position":"120302316-120313249","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins"],"Biological process":["DNA damage"],"Molecular function":["Glycosyltransferase","Nucleotidyltransferase","Transferase"],"Disease involvement":["Cancer-related genes","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"39.0","Late primary spermatocytes":"42.1","Myonuclei":"28.0","Rod photoreceptor cells":"17.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"28.0","Spermatogenic cell types":"42.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"139","Protein cell type specific Intensity":{"Distal tubules":"13878.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2093","Protein tissue specific Intensity":{"intestine":"209261.5"},"Antibody":["HPA029691","HPA029692"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029691":null,"HPA029692":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.93e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.39e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"}},{"Gene":"SIVA1","Gene synonym":["CD27BP","SIVA","Siva-1","Siva-2"],"Ensembl":"ENSG00000184990","Gene description":"SIVA1 apoptosis inducing factor","Uniprot":["O15304"],"Chromosome":"14","Position":"104753147-104768494","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"419.9","Late primary spermatocytes":"451.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA065398","HPA066693"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":23,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA065398":null,"HPA066693":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"}},{"Gene":"SKA1","Gene synonym":["C18orf24","MGC10200"],"Ensembl":"ENSG00000154839","Gene description":"Spindle and kinetochore associated complex subunit 1","Uniprot":["Q96BD8"],"Chromosome":"18","Position":"50375040-50394168","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"11.2","lymphoid tissue":"4.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"1.6","Early spermatids":"1.9","Erythrocyte progenitors":"7.0","Late primary spermatocytes":"1.2","Megakaryocyte progenitors":"3.4","Monocyte progenitors":"4.4","Plasma cells":"1.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"7.0","Megakaryocytes":"3.4","Mononuclear phagocytes":"4.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"1.6","upper rhombic lip":"1.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2729933.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045495"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Cytokinetic bridge","Primary cilium","Centriolar satellite","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":27,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Cytokinetic bridge","Centriolar satellite","Basal body"],"Antibody RRID":{"HPA045495":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.68e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.20e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.59e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.72e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"}},{"Gene":"SKAP1","Gene synonym":["SCAP1","SKAP55"],"Ensembl":"ENSG00000141293","Gene description":"Src kinase associated phosphoprotein 1","Uniprot":["Q86WV1"],"Chromosome":"17","Position":"48133442-48430275","Protein class":["Predicted intracellular proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"33.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"409.3","Gonadotrophs":"303.8","Hematopoietic stem cells":"306.7","Innate lymphoid cells":"386.0","Loop of henle epithelial cells":"348.0","Mast cells":"495.8","NK-cells":"1237.0","Renal collecting duct intercalated cells":"494.0","Renal collecting duct principal cells":"365.8","Renal connecting tubule cells":"360.2","T-cells":"1058.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"NK-cells":"1237.0","T-cells":"1058.7"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"29","RNA single nuclei brain specific nCPM":{"leukocyte":"1622.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"20.8","Rhabdoid":"28.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Heart muscle - T-cells","Liver - Hepatocytes","Lung - T-cells","Prostate - T-cells","Spleen - T-cells","Stomach - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"20348164.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"36952","Protein tissue specific Intensity":{"bone marrow":"2106356.9","lymphoid tissue":"5283955.5"},"Antibody":["HPA002969","CAB025882","CAB055513"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":10,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB025882":null,"CAB055513":null,"HPA002969":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"980000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 22: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA005560":null,"HPA024045":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.22e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"}},{"Gene":"SKIC8","Gene synonym":["REC14","SKI8","WDR61"],"Ensembl":"ENSG00000140395","Gene description":"SKI8 subunit of superkiller complex","Uniprot":["Q9GZS3"],"Chromosome":"15","Position":"78277835-78299703","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal principal cells":"226.5","Late primary spermatocytes":"224.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039932","HPA040065"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":116,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039932":null,"HPA040065":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.79e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"}},{"Gene":"SLAIN2","Gene synonym":["FLJ21611","KIAA1458"],"Ensembl":"ENSG00000109171","Gene description":"SLAIN motif family member 2","Uniprot":["Q9P270"],"Chromosome":"4","Position":"48341529-48426201","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"563.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"563.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"5287786.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"771435.5","liver":"1879863.3","lymphoid tissue":"907662.5","Stomach":"1434376.3"},"Antibody":["HPA035824","HPA063599"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Primary cilium tip","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"96000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":24,"Subcellular main location":["Centrosome","Cytosol"],"Subcellular additional location":["Primary cilium tip","Basal body"],"Antibody RRID":{"HPA035824":null,"HPA063599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.06e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.63e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.85e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"}},{"Gene":"SLC10A4","Gene synonym":["MGC29802"],"Ensembl":"ENSG00000145248","Gene description":"Solute carrier family 10 member 4","Uniprot":["Q96EP9"],"Chromosome":"4","Position":"48483343-48489526","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"10.8","pituitary gland":"5.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"9.3","Erythrocyte progenitors":"19.0","Gonadotrophs":"5.9","Late spermatids":"7.0","Megakaryocyte-Erythroid progenitors":"8.4","Oocytes":"9.2","Other brain neurons":"39.3","Retinal amacrine cells":"6.9","Salivary myoepithelial cells":"9.4","Thyrotrophs":"33.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"19.0","Neuronal cells":"39.3","Pituitary endocrine cells":"33.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"CGE interneuron":"42.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.6"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"midbrain":"79.9"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"Adrenocortical cancer":"23.7","Neuroblastoma":"50.9"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pituitary gland - Thyrotropes","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Group enriched","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":"5","RNA pig brain regional specific nTPM":{"basal ganglia":"22.4","midbrain":"88.3","pons":"36.8","spinal cord":"70.0"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"228","Protein cell type specific Intensity":{"T-cells":"22849.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028835"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":"Supported","Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 36: Brain & Liver - Signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028835":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC12A1","Gene synonym":["BSC","BSC-1","BSC1","CCC2","NKCC2"],"Ensembl":"ENSG00000074803","Gene description":"Solute carrier family 12 member 1","Uniprot":["Q13621"],"Chromosome":"15","Position":"48178438-48304078","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Potassium transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Bartter syndrome","Disease variant","FDA approved drug targets","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"826","RNA tissue specific nTPM":{"kidney":"664.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"29","RNA single cell type specific nCPM":{"Loop of henle epithelial cells":"3067.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"29","RNA single cell type group specific nCPM":{"Renal nephron cells":"3067.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"4.8","Kidney Renal Clear Cell Carcinoma (TCGA)":"2.9","Kidney Renal Papillary Cell Carcinoma (TCGA)":"6.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Ascending Loop of Henle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"157016165.6","Keratinocytes":"245656882.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"11741","Protein tissue specific Intensity":{"kidney":"1174095.9"},"Antibody":["HPA014967","HPA018107"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA014967":null,"HPA018107":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC12A2","Gene synonym":["BSC-2","BSC2","CCC1","NKCC1","PPP1R141"],"Ensembl":"ENSG00000064651","Gene description":"Solute carrier family 12 member 2","Uniprot":["P55011"],"Chromosome":"5","Position":"128083766-128189677","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Potassium transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","FDA approved drug targets","Intellectual disability","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"salivary gland":"71.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast secretory cells":"601.9","Enteric stem cells":"983.9","Gastric chief cells":"741.5","Goblet cells":"688.5","Lacrimal acinar cells":"722.9","Mucous neck cells":"1033.7","Oligodendrocytes":"669.1","Paneth cells":"1001.7","Parietal cells":"601.1","Prostatic glandular cells":"761.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"1033.7","Secretory gland support":"1001.7","Stem cells":"983.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"848.9","pericyte":"922.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"113.8","Rectum Adenocarcinoma (TCGA)":"103.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"6.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"106.3"},"RNA tissue cell type enrichment":["Adipose visceral - Endothelial cells","Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells (progenitors)","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"30392936.2","Microglia and Neuropil":"24797113.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"109743342.5"},"Antibody":["HPA020130","HPA063697"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":23,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA020130":null,"HPA063697":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.01e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.73e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.52e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.68e-4"}},{"Gene":"SLC12A6","Gene synonym":["ACCPN","KCC3","KCC3A","KCC3B"],"Ensembl":"ENSG00000140199","Gene description":"Solute carrier family 12 member 6","Uniprot":["Q9UHW9"],"Chromosome":"15","Position":"34229784-34338060","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Potassium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"2078.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neutrophils":"2078.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"basophil":"15.2","neutrophil":"23.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"granulocytes":"23.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":26,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA034563":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.32e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"SLC13A3","Gene synonym":["NADC3","SDCT2"],"Ensembl":"ENSG00000158296","Gene description":"Solute carrier family 13 member 3","Uniprot":["Q8WWT9"],"Chromosome":"20","Position":"46557823-46684467","Protein class":["Disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Lipid transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"kidney":"379.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Proximal tubule cells":"1346.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Renal nephron cells":"1346.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Kidney - Proximal tubular cells","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1","Protein cell type specific Intensity":{"Glomeruli":"13227988.2","Proximal tubules":"34216210.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"462","Protein tissue specific Intensity":{"kidney":"46232.4"},"Antibody":["HPA014333","HPA014353","HPA014736"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA014333":null,"HPA014353":null,"HPA014736":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":20,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016713":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":13,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA005911":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA050513":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":2,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA044479":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.00e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"SLC1A2","Gene synonym":["EAAT2","GLT-1","GLT1","HBGT"],"Ensembl":"ENSG00000110436","Gene description":"Solute carrier family 1 member 2","Uniprot":["P43004"],"Chromosome":"11","Position":"35251205-35420063","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"brain":"1024.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Astrocytes":"6365.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Glial cells":"6365.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"astrocyte":"5025.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"93.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1.3"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"6.4","Neuroblastoma":"4.0"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"18000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB002574":null,"HPA009172":null,"HPA067499":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"}},{"Gene":"SLC1A5","Gene synonym":["AAAT","ASCT2","M7V1","RDRC"],"Ensembl":"ENSG00000105281","Gene description":"Solute carrier family 1 member 5","Uniprot":["Q15758"],"Chromosome":"19","Position":"46774883-46788594","Protein class":["FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Antiport","Host-virus interaction","Symport","Transport"],"Molecular function":["Host cell receptor for virus entry","Receptor"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal prostatic cells":"157.5","Extravillous trophoblasts":"177.6","Prostatic hillock cells":"188.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"30.1","leukocyte":"12.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"96.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Minor Salivary Gland - Minor salivary gland ductal cells","Prostate - Prostate basal glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"9721532.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"10775574.8"},"Antibody":["HPA035239","HPA035240"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Centriolar satellite","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"27000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":33,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Centriolar satellite","Basal body"],"Antibody RRID":{"HPA035239":null,"HPA035240":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"}},{"Gene":"SLC22A14","Gene synonym":["OCTL2","ORCTL4"],"Ensembl":"ENSG00000144671","Gene description":"Solute carrier family 22 member 14","Uniprot":["Q9Y267"],"Chromosome":"3","Position":"38282294-38318575","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"10.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"92.3","Late primary spermatocytes":"48.2","Late spermatids":"174.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"174.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037556"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Perinuclear theca","Connecting piece","Mid piece","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":["Connecting piece","Mid piece","Principal piece"],"Subcellular additional location":["Perinuclear theca"],"Antibody RRID":{"HPA037556":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC22A16","Gene synonym":["CT2","FLIPT2","OAT6","OKB1"],"Ensembl":"ENSG00000004809","Gene description":"Solute carrier family 22 member 16","Uniprot":["Q86VW1"],"Chromosome":"6","Position":"110424687-110476641","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Differentiation","Ion transport","Spermatogenesis","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"bone marrow":"19.3","testis":"20.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"36.0","Erythrocyte progenitors":"119.9","Hematopoietic stem cells":"49.5","Late primary spermatocytes":"112.5","Late spermatids":"45.8","Megakaryocyte progenitors":"18.1","Monocyte progenitors":"32.2","Neutrophil progenitors":"45.1","Thymocytes":"22.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"119.9","Neutrophils":"45.1","Spermatogenic cell types":"112.5","Stem cells":"49.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"5.8","classical monocyte":"7.0"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"56","RNA blood lineage specific nTPM":{"dendritic cells":"4.0","granulocytes":"5.8","monocytes":"7.0"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"Leukemia":"10.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036902"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":2,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036902":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"}},{"Gene":"SLC22A23","Gene synonym":["C6orf85","FLJ22174"],"Ensembl":"ENSG00000137266","Gene description":"Solute carrier family 22 member 23","Uniprot":["A1A5C7"],"Chromosome":"6","Position":"3268962-3457050","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Foveolar cells":"612.4","Goblet cells":"380.9","Late spermatids":"429.1","Prostatic glandular cells":"844.8","Renal collecting duct intercalated cells":"499.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"612.4","Glandular cells":"844.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":3,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA014697":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.09e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.46e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 53: Liver - Plasma proteins","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030220":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC24A5","Gene synonym":["JSX","OCA6"],"Ensembl":"ENSG00000188467","Gene description":"Solute carrier family 24 member 5","Uniprot":["Q71RS6"],"Chromosome":"15","Position":"48120990-48142672","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Calcium transport","Ion transport","Potassium transport","Sensory transduction","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Albinism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skin 1":"7.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"41.5","Early spermatids":"62.2","Late spermatids":"66.4","Melanocytes":"199.0","Retinal amacrine cells":"36.1","Retinal bipolar cells":"24.1","Retinal ganglion cells":"30.9","Retinal horizontal cells":"44.1","Retinal pigment epithelial cells":"38.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"41.5","Neuronal cells":"44.1","Pigment cells":"199.0","Spermatogenic cell types":"66.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"18","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"101.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"63","RNA cell line specific nTPM":{"skin cancer":"98.8"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"}},{"Gene":"SLC25A10","Gene synonym":["DIC"],"Ensembl":"ENSG00000183048","Gene description":"Solute carrier family 25 member 10","Uniprot":["Q9UBX3"],"Chromosome":"17","Position":"81712236-81721016","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"179.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"48.2","Enteric stem cells":"43.2","Enteric transient amplifying cells":"58.0","Enterocytes":"40.8","Esophageal basal cells":"68.5","Esophageal suprabasal cells":"52.7","Hepatocytes":"47.0","Late primary spermatocytes":"81.3","Late spermatids":"141.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"68.5","Spermatogenic cell types":"141.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"1.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":16,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023048":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"SLC25A19","Gene synonym":["DNC","MCPHA","MUP1","TPC"],"Ensembl":"ENSG00000125454","Gene description":"Solute carrier family 25 member 19","Uniprot":["Q9HC21"],"Chromosome":"17","Position":"75272981-75289510","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"87.9","Extravillous trophoblasts":"115.9","Hofbauer cells":"42.9","Late primary spermatocytes":"171.0","monocytes":"48.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"87.9","Spermatogenic cell types":"171.0","Trophoblast cells":"115.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":28,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA021936":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.37e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.53e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.62e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-3"}},{"Gene":"SLC25A2","Gene synonym":["ORNT2"],"Ensembl":"ENSG00000120329","Gene description":"Solute carrier family 25 member 2","Uniprot":["Q9BXI2"],"Chromosome":"5","Position":"141302635-141304049","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"testis":"6.3"},"RNA single cell type specificity":"Not detected","RNA single cell type distribution":"Not detected","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Not detected","RNA single cell type group distribution":"Not detected","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042146"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":null,"Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC25A28","Gene synonym":["MRS3\/4","MRS4L"],"Ensembl":"ENSG00000155287","Gene description":"Solute carrier family 25 member 28","Uniprot":["Q96A46"],"Chromosome":"10","Position":"99610519-99622793","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Iron transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"137.9","Late primary spermatocytes":"178.6","Late spermatids":"686.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"686.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":17,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA015064":null,"HPA016841":null,"HPA046835":null,"HPA071684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049982":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.76e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026785":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.50e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.79e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"}},{"Gene":"SLC25A46","Gene synonym":[],"Ensembl":"ENSG00000164209","Gene description":"Solute carrier family 25 member 46","Uniprot":["Q96AG3"],"Chromosome":"5","Position":"110738136-110765161","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"221.2","Late spermatids":"760.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"760.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":36,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA039601":null,"HPA071582":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.59e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"SLC25A51","Gene synonym":["CG7943","MCART1","MGC14836"],"Ensembl":"ENSG00000122696","Gene description":"Solute carrier family 25 member 51","Uniprot":["Q9H1U9"],"Chromosome":"9","Position":"37879400-37904353","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Astrocytes":"22.2","Bergmann glia":"25.2","Brain excitatory neurons":"27.5","Brain inhibitory neurons":"29.3","Choroid plexus epithelial cells":"27.6","Ependymal cells":"13.8","Microglia":"20.3","Oligodendrocyte progenitor cells":"23.8","Oligodendrocytes":"27.8","Other brain neurons":"27.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"27.6","Glial cells":"27.8","Neuronal cells":"29.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"basophil":"16.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"16.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":3,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA046388":null,"HPA058261":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.20e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"}},{"Gene":"SLC25A52","Gene synonym":["MCART2"],"Ensembl":"ENSG00000141437","Gene description":"Solute carrier family 25 member 52","Uniprot":["Q3SY17"],"Chromosome":"18","Position":"31759584-31760880","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"testis":"9.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"39","RNA single cell type specific nCPM":{"Early spermatids":"49.3","Late primary spermatocytes":"58.2","Late spermatids":"163.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"146","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"163.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA046388":null,"HPA058261":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC26A3","Gene synonym":["CLD","DRA"],"Ensembl":"ENSG00000091138","Gene description":"Solute carrier family 26 member 3","Uniprot":["P40879"],"Chromosome":"7","Position":"107765467-107803225","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"intestine":"1050.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Colonocytes":"4022.8","Enterocytes":"1364.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Enterocytes":"4022.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"13","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"77.5","Rectum Adenocarcinoma (TCGA)":"94.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"25","RNA cell line specific nTPM":{"colorectal cancer":"16.6"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":1,"Subcellular main location":["Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA036055":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC26A4","Gene synonym":["DFNB4","PDS"],"Ensembl":"ENSG00000091137","Gene description":"Solute carrier family 26 member 4","Uniprot":["O43511"],"Chromosome":"7","Position":"107660828-107717809","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"29","RNA tissue specific nTPM":{"thyroid gland":"247.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Renal collecting duct intercalated cells":"442.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ductal cells":"442.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer intratelencephalic":"108.4","hippocampal CA1-3":"144.5","MGE interneuron":"108.7","miscellaneous":"103.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"119.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"naive B-cell":"1.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"B-cells":"1.0"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"lymphoma":"16.1"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 33: Thyroid gland - Tissue development","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042860":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC26A8","Gene synonym":["TAT1"],"Ensembl":"ENSG00000112053","Gene description":"Solute carrier family 26 member 8","Uniprot":["Q96RN1"],"Chromosome":"6","Position":"35943516-36024868","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Anion exchange","Differentiation","Ion transport","Meiosis","Spermatogenesis","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"41.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"152.1","Neutrophil progenitors":"104.7","Neutrophils":"268.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neutrophils":"268.2","Spermatogenic cell types":"152.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"neutrophil":"2.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"granulocytes":"2.5"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":3,"Subcellular main location":["Annulus"],"Subcellular additional location":["Acrosome"],"Antibody RRID":{"HPA038080":null,"HPA038081":null,"HPA061393":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC27A4","Gene synonym":["ACSVL4","FATP4"],"Ensembl":"ENSG00000167114","Gene description":"Solute carrier family 27 member 4","Uniprot":["Q6P1M0"],"Chromosome":"9","Position":"128340527-128361470","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Fatty acid metabolism","Lipid metabolism","Lipid transport","Transport"],"Molecular function":["Ligase"],"Disease involvement":["Disease variant","Ichthyosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"571.6","Enteric transient amplifying cells":"198.6","Enterocytes":"313.6","Epididymal clear cells":"234.8","Esophageal apical cells":"207.1","Foveolar cells":"392.4","Gastric chief cells":"310.1","Gastric progenitor cells":"232.0","Goblet cells":"278.0","Megakaryocytes":"234.9","Parietal cells":"272.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"571.6","Gastric glandular cells":"392.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"14868161.7"},"Antibody":["HPA007293","CAB009771"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":30,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB009771":null,"HPA007293":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"}},{"Gene":"SLC27A5","Gene synonym":["ACSB","ACSVL6","FACVL3","FATP5","FLJ22987","VLACSR","VLCS-H2","VLCSH2"],"Ensembl":"ENSG00000083807","Gene description":"Solute carrier family 27 member 5","Uniprot":["Q9Y2P5"],"Chromosome":"19","Position":"58479512-58512413","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Fatty acid metabolism","Lipid metabolism","Lipid transport","Transport"],"Molecular function":["Ligase","Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"24","RNA tissue specific nTPM":{"liver":"989.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Hepatocytes":"554.8","Late spermatids":"807.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Hepatocytes":"554.8","Spermatogenic cell types":"807.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"386.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"403305393.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"59066437.5","fallopian tube":"21506468.3","intestine":"35729409.3","liver":"81842804.1"},"Antibody":["HPA007292","CAB056160","CAB068239"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB056160":null,"CAB068239":null,"HPA007292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.43e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"}},{"Gene":"SLC2A14","Gene synonym":["GLUT14","SLC2A3P3"],"Ensembl":"ENSG00000173262","Gene description":"Solute carrier family 2 member 14","Uniprot":["Q8TDB8"],"Chromosome":"12","Position":"7812512-7891148","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Differentiation","Spermatogenesis","Sugar transport","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"76.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"89.3","Early primary spermatocytes":"64.0","Erythrocyte progenitors":"45.7","Granulosa cells":"61.6","Late primary spermatocytes":"103.0","Megakaryocyte-Erythroid progenitors":"23.4","Neutrophils":"38.6","Pancreatic acinar cells":"109.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"109.4","Adrenal endocrine cells":"89.3","Reproductive supporting cells":"61.6","Spermatogenic cell types":"103.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"19.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"25.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"3.7","neutrophil":"3.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"testis cancer":"32.7"},"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006539"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA006539":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.62e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"}},{"Gene":"SLC2A5","Gene synonym":["GLUT5"],"Ensembl":"ENSG00000142583","Gene description":"Solute carrier family 2 member 5","Uniprot":["P22732"],"Chromosome":"1","Position":"9035106-9088478","Protein class":["Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Sugar transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"91.5","intestine":"102.6","skeletal muscle":"73.9","testis":"71.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"32.5","Early spermatids":"51.2","Enterocytes":"211.9","Hematopoietic stem cells":"48.5","Late primary spermatocytes":"158.2","Microglia":"179.4","Myonuclei":"35.3","Neutrophil progenitors":"80.2","Plasma cells":"38.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"211.9","Glial cells":"179.4","Neutrophils":"80.2","Spermatogenic cell types":"158.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"33","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"213.3"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"33.2","Kidney Renal Clear Cell Carcinoma (TCGA)":"55.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"naive B-cell":"23.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"23.3"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"Leukemia":"40.5","lymphoma":"53.5","Myeloma":"32.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 34: B-cells - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":12,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA005449":null,"HPA075145":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.25e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"}},{"Gene":"SLC2A8","Gene synonym":["GLUT8","GLUTX1"],"Ensembl":"ENSG00000136856","Gene description":"Solute carrier family 2 member 8","Uniprot":["Q9NY64"],"Chromosome":"9","Position":"127397138-127408424","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Sugar transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"98.5","Decidual stromal cells":"166.5","Early spermatids":"151.7","Endometrial stromal cells":"77.7","Epididymal principal cells":"81.0","Hofbauer cells":"139.2","Late primary spermatocytes":"195.0","Late spermatids":"582.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"139.2","Spermatogenic cell types":"582.2","Stromal cells":"166.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"plasmacytoid DC":"76.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"76.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"142","Protein cell type specific Intensity":{"Neurons":"14203.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"280300.2","lymphoid tissue":"956152.3"},"Antibody":["HPA011935"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":25,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA011935":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.66e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.47e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.44e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.63e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"}},{"Gene":"SLC30A1","Gene synonym":["ZNT1","ZRC1"],"Ensembl":"ENSG00000170385","Gene description":"Solute carrier family 30 member 1","Uniprot":["Q9Y6M5"],"Chromosome":"1","Position":"211571568-211579161","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Ion transport","Transport","Zinc transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"80.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial luminal cells":"77.1","Epididymal efferent duct absorptive cells":"76.9","Epididymal efferent duct ciliated cells":"98.2","Hepatocytes":"105.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"endothelial cell":"224.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"79.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 104: Brain endothelial cells - Blood brain barrier","Interactions":21,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA015275":null,"HPA049000":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.14e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"}},{"Gene":"SLC30A10","Gene synonym":["DKFZp547M236","ZnT-10","ZNT8","ZRC1"],"Ensembl":"ENSG00000196660","Gene description":"Solute carrier family 30 member 10","Uniprot":["Q6XR72"],"Chromosome":"1","Position":"219685427-219959018","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Ion transport","Transport","Zinc transport"],"Molecular function":null,"Disease involvement":["Disease variant","Dystonia","Neurodegeneration","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"intestine":"23.1","liver":"44.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"110.9","Bergmann glia":"133.3","Choroid plexus epithelial cells":"134.3","Colonocytes":"159.3","Early spermatids":"75.9","Enterocytes":"129.5","Hepatocytes":"237.2","Plasma cells":"218.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"134.3","Enterocytes":"159.3","Glial cells":"133.3","Hepatocytes":"237.2","Plasma cells":"218.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"pericyte":"1371.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"17","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"18.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"1.6"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Liver - Hepatocytes","Pituitary gland - Gonadotropes","Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"9997","Protein cell type specific Intensity":{"Hepatocytes":"999739.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"574036.2"},"Antibody":["HPA064547"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA064547":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC32A1","Gene synonym":["bA122O1.1","VGAT","VIAAT"],"Ensembl":"ENSG00000101438","Gene description":"Solute carrier family 32 member 1","Uniprot":["Q9H598"],"Chromosome":"20","Position":"38724486-38729372","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Neurotransmitter transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"44.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Brain inhibitory neurons":"33.4","Other brain neurons":"28.2","pDCs":"28.1","Retinal amacrine cells":"55.4","Retinal horizontal cells":"32.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"dendritic cells":"28.1","Neuronal cells":"55.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"16","RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"47.7","CGE interneuron":"50.6","eccentric medium spiny neuron":"28.7","LAMP5-LHX6 and Chandelier":"54.1","medium spiny neuron":"21.5","MGE interneuron":"33.5","midbrain-derived inhibitory":"41.0","splatter":"19.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - Thyrotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"108518","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"9490555.9","Microglia and Neuropil":"17956049.7","Neurons":"5108672.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"112742","Protein tissue specific Intensity":{"cerebral cortex":"11274193.4"},"Antibody":["CAB037156","HPA058859","HPA059985"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Uncertain","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB037156":null,"HPA058859":null,"HPA059985":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC34A2","Gene synonym":["NAPI-3B"],"Ensembl":"ENSG00000157765","Gene description":"Solute carrier family 34 member 2","Uniprot":["O95436"],"Chromosome":"4","Position":"25648011-25678748","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"lung":"709.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"867.2","Alveolar cells type 2":"1909.3","Breast lactating cells":"291.0","Endometrial glandular cells":"419.7","Endometrial secretory cells":"444.3","Respiratory ciliated cells":"218.0","Transitional alveolar cells":"1120.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Alveolar cells":"1909.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"19","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"8.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"764.9","Thyroid Carcinoma (TCGA)":"986.8"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"cerebellum":"5.4","choroid plexus":"15.6"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"53.2","ovarian cancer":"115.1","pancreatic cancer":"54.6","Uterine cancer":"52.8"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 13: Lung - Secretion","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":13,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA037989":null,"HPA066474":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":12,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA049558":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - 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Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"}},{"Gene":"SLC35G3","Gene synonym":["AMAC1","FLJ40154","TMEM21A"],"Ensembl":"ENSG00000164729","Gene description":"Solute carrier family 35 member G3","Uniprot":["Q8N808"],"Chromosome":"17","Position":"35192520-35194393","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"testis":"2.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"19.9","Late primary spermatocytes":"23.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"23.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC36A3","Gene synonym":["PAT3","TRAMD2","tramdorin2"],"Ensembl":"ENSG00000186334","Gene description":"Solute carrier family 36 member 3","Uniprot":["Q495N2"],"Chromosome":"5","Position":"151276358-151303766","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"30","RNA tissue specific nTPM":{"testis":"7.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Early spermatids":"88.0","Late spermatids":"225.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"58","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"225.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC37A1","Gene synonym":["SPX1"],"Ensembl":"ENSG00000160190","Gene description":"Solute carrier family 37 member 1","Uniprot":["P57057"],"Chromosome":"21","Position":"42496008-42581440","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Sugar transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"43.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"682.2","Early spermatids":"210.5","Megakaryocyte progenitors":"221.7","Megakaryocytes":"210.2","M\u00fcller glia":"207.7","Somatotrophs":"246.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Secretory cells":"682.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 4: Breast lactating luminal cells - Lactation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB034154":null,"HPA030418":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.37e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"}},{"Gene":"SLC38A6","Gene synonym":["NAT-1"],"Ensembl":"ENSG00000139974","Gene description":"Solute carrier family 38 member 6","Uniprot":["Q8IZM9"],"Chromosome":"14","Position":"60981114-61114316","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"199.9","Hofbauer cells":"185.9","Late primary spermatocytes":"158.6","Late spermatids":"221.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"185.9","Spermatogenic cell types":"221.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":1,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Plasma membrane","Microtubules"],"Antibody RRID":{"HPA018508":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.00e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"}},{"Gene":"SLC38A9","Gene synonym":["FLJ90709"],"Ensembl":"ENSG00000177058","Gene description":"Solute carrier family 38 member 9","Uniprot":["Q8NBW4"],"Chromosome":"5","Position":"55625845-55773194","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"54.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"382.3","Early spermatids":"337.4","Migrating cytotrophoblasts":"411.1","Syncytiotrophoblasts":"1294.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"337.4","Trophoblast cells":"1294.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":27,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA043785":null,"HPA061702":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"SLC39A3","Gene synonym":["ZIP3"],"Ensembl":"ENSG00000141873","Gene description":"Solute carrier family 39 member 3","Uniprot":["Q9BRY0"],"Chromosome":"19","Position":"2732204-2740028","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport","Zinc transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"97.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"3.2","Hematopoietic stem cells":"2.9","Hepatic stellate cells":"6.5","Late primary spermatocytes":"5.2","Late spermatids":"11.3","Medullary thymic epithelial cells":"2.4","Megakaryocyte progenitors":"2.6","Megakaryocyte-Erythroid progenitors":"4.3","Retinal pigment epithelial cells":"4.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"4.3","Pigment cells":"4.3","Spermatogenic cell types":"11.3","Stellate cells":"6.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042139","HPA058526"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":11,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA042139":null,"HPA058526":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"}},{"Gene":"SLC3A1","Gene synonym":["ATR1","CSNU1","D2H","NBAT","RBAT"],"Ensembl":"ENSG00000138079","Gene description":"Solute carrier family 3 member 1","Uniprot":["Q07837"],"Chromosome":"2","Position":"44275458-44321494","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Transport"],"Molecular function":null,"Disease involvement":["Cystinuria","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"128.1","kidney":"604.7","pancreas":"205.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"201.4","Endometrial glandular cells":"59.3","Endometrial luminal cells":"152.0","Enterocytes":"206.1","Epididymal efferent duct absorptive cells":"95.8","Loop of henle epithelial cells":"122.6","Oocytes":"170.4","Pancreatic duct cells":"200.2","Proximal tubule cells":"272.8","Renal collecting duct intercalated cells":"82.0","Renal connecting tubule cells":"115.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"200.2","Enterocytes":"206.1","Luminal cells":"152.0","Oocytes":"170.4","Renal nephron cells":"272.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"524.6","Kidney Renal Papillary Cell Carcinoma (TCGA)":"490.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"15.1","Kidney cancer":"17.1"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"45180473.1","Proximal tubules":"119482056.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"52467","Protein tissue specific Intensity":{"intestine":"8951862.7","kidney":"3879267.3","pancreas":"2908903.7"},"Antibody":["HPA038360","HPA071102"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA038360":null,"HPA071102":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.46e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.68e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"}},{"Gene":"SLC44A5","Gene synonym":["CTL5","MGC34032"],"Ensembl":"ENSG00000137968","Gene description":"Solute carrier family 44 member 5","Uniprot":["Q8NCS7"],"Chromosome":"1","Position":"75202129-75611114","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skin 1":"10.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"241.9","Brain inhibitory neurons":"276.3","Early spermatids":"278.8","Gonadotrophs":"918.5","Granulosa cells":"271.7","Lactotrophs":"168.0","Late primary spermatocytes":"173.3","Oligodendrocyte progenitor cells":"366.4","Other brain neurons":"367.5","Thymic myoid cells":"284.2","Thyrotrophs":"318.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"366.4","Neuronal cells":"367.5","Pituitary endocrine cells":"918.5","Spermatogenic cell types":"278.8","Stromal cells":"284.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"47416.5","Oocytes":"178626.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047455","HPA051011"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":11,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA047455":null,"HPA051011":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"}},{"Gene":"SLC49A3","Gene synonym":["FLJ22269","LP2561","MFSD7"],"Ensembl":"ENSG00000169026","Gene description":"Solute carrier family 49 member 3","Uniprot":["Q6UXD7"],"Chromosome":"4","Position":"681829-689271","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"39.6","Decidual stromal cells":"24.8","Early spermatids":"36.7","Esophageal apical cells":"32.1","Extravillous trophoblasts":"46.4","Kupffer cells":"24.6","Late primary spermatocytes":"52.9","Late spermatids":"55.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Secretory cells":"39.6","Spermatogenic cell types":"55.6","Trophoblast cells":"46.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"7.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"30.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043593":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"}},{"Gene":"SLC4A10","Gene synonym":["NBCn2","NCBE"],"Ensembl":"ENSG00000144290","Gene description":"Solute carrier family 4 member 10","Uniprot":["Q6U841"],"Chromosome":"2","Position":"161424332-161985282","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Ion transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Autism spectrum disorder","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"brain":"32.6","choroid plexus":"54.0","retina":"31.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"536.6","Brain inhibitory neurons":"522.7","Choroid plexus epithelial cells":"2418.8","Oligodendrocyte progenitor cells":"218.6","Other brain neurons":"361.4","Retinal amacrine cells":"352.5","Retinal bipolar cells":"726.1","Retinal ganglion cells":"231.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"2418.8","Neuronal cells":"726.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"2639.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.8"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"311.0"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"MAIT T-cell":"63.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"65","RNA blood lineage specific nTPM":{"T-cells":"63.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"1.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034755":null,"HPA076725":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC4A1AP","Gene synonym":["HLC3","kanadaptin"],"Ensembl":"ENSG00000163798","Gene description":"Solute carrier family 4 member 1 adaptor protein","Uniprot":["Q9BWU0"],"Chromosome":"2","Position":"27663426-27695366","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"147.9","Late primary spermatocytes":"102.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"147.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":36,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"HPA036679":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.84e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.53e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"}},{"Gene":"SLC4A4","Gene synonym":["hhNMC","HNBC1","NBC1","NBC2","pNBC","SLC4A5"],"Ensembl":"ENSG00000080493","Gene description":"Solute carrier family 4 member 4","Uniprot":["Q9Y6R1"],"Chromosome":"4","Position":"71062667-71572087","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"111.6","pancreas":"245.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"1379.0","Bergmann glia":"4233.7","Colonocytes":"579.5","Pancreatic duct cells":"3794.9","Pituicytes\/FSCs":"1072.2","Prostatic glandular cells":"666.1","Proximal tubule cells":"967.8","Retinal ganglion cells":"691.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ductal cells":"3794.9","Glial cells":"4233.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"1523.4","Bergmann glia":"4574.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"40.3","Kidney Renal Clear Cell Carcinoma (TCGA)":"36.9","Kidney Renal Papillary Cell Carcinoma (TCGA)":"26.3","Pancreatic Adenocarcinoma (TCGA)":"32.3","Prostate Adenocarcinoma (TCGA)":"71.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"21.0","prostate cancer":"13.6"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Kidney - Proximal tubular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"81398862.0","Proximal tubules":"187715628.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"111421741.1","intestine":"35752409.4","kidney":"72947299.5","pancreas":"63985901.8"},"Antibody":["CAB022493","HPA035628","HPA035629","HPA079220"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4500","Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":4,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB022493":null,"HPA035628":null,"HPA035629":null,"HPA079220":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.95e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.31e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.95e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.79e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-3"}},{"Gene":"SLC4A8","Gene synonym":["NBC3"],"Ensembl":"ENSG00000050438","Gene description":"Solute carrier family 4 member 8","Uniprot":["Q2Y0W8"],"Chromosome":"12","Position":"51391317-51515763","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Anion exchange","Antiport","Ion transport","Sodium transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"12.0","pituitary gland":"16.9","retina":"10.3","testis":"11.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"219.4","Corticotrophs":"192.4","Gonadotrophs":"178.9","Lactotrophs":"359.5","Oligodendrocytes":"239.9","Retinal amacrine cells":"206.6","Retinal bipolar cells":"173.2","Retinal horizontal cells":"222.4","Somatotrophs":"395.6","Thyrotrophs":"399.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"239.9","Neuronal cells":"222.4","Pituitary endocrine cells":"399.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"4.4","Glioblastoma Multiforme (TCGA)":"7.6","Testicular Germ Cell Tumor (TCGA)":"11.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Neuroblastoma":"24.4"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Pancreas - Beta cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1230262.0","Microglia and Neuropil":"1976326.9","Neurons":"844359.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"27277","Protein tissue specific Intensity":{"cerebral cortex":"2727695.1"},"Antibody":["HPA077895"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA077895":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.23e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.28e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"SLC51B","Gene synonym":["OSTbeta"],"Ensembl":"ENSG00000186198","Gene description":"Solute carrier family 51 subunit beta","Uniprot":["Q86UW2"],"Chromosome":"15","Position":"65045387-65053397","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"39.4","intestine":"100.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Colonocytes":"335.8","Enterocytes":"679.6","Epididymal efferent duct absorptive cells":"241.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ductal cells":"241.3","Enterocytes":"679.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"astrocyte":"6.1","ependymal cell":"6.3","pericyte":"4.3","vascular associated smooth muscle cell":"7.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"18.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"12.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Colon - Colon enterocytes","Kidney - Proximal tubular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"5461","Protein cell type specific Intensity":{"Proximal tubules":"546146.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"9006","Protein tissue specific Intensity":{"kidney":"900583.1"},"Antibody":["HPA008398","HPA008533"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":4,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA008398":null,"HPA008533":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":1,"Subcellular main location":["Golgi apparatus","Plasma membrane"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"CAB015467":null,"HPA051805":null,"HPA055106":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.06e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.70e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041603":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC5A8","Gene synonym":["AIT"],"Ensembl":"ENSG00000256870","Gene description":"Solute carrier family 5 member 8","Uniprot":["Q8N695"],"Chromosome":"12","Position":"101155493-101210238","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Apoptosis","Ion transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"cervix":"19.0","kidney":"5.2","thyroid gland":"14.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"17.0","Brain inhibitory neurons":"22.8","Early spermatids":"7.2","Lacrimal acinar cells":"10.9","Loop of henle epithelial cells":"10.0","Neuroendocrine cells":"6.9","Other brain neurons":"11.2","Proximal tubule cells":"59.6","Renal connecting tubule cells":"22.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"22.5","Neuronal cells":"22.8","Renal nephron cells":"59.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"mammillary body":"128.3","midbrain-derived inhibitory":"89.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"12.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"breast cancer":"1.4"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 33: Thyroid gland - Tissue development","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.80e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"}},{"Gene":"SLC6A13","Gene synonym":["GAT2"],"Ensembl":"ENSG00000010379","Gene description":"Solute carrier family 6 member 13","Uniprot":["Q9NSD5"],"Chromosome":"12","Position":"220621-262873","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Neurotransmitter transport","Symport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"kidney":"142.8","liver":"36.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"14","RNA single cell type specific nCPM":{"Proximal tubule cells":"421.7","Retinal pigment epithelial cells":"733.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Pigment cells":"733.2","Renal nephron cells":"421.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"31","RNA single nuclei brain specific nCPM":{"fibroblast":"408.5","pericyte":"665.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"16","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"135.1","Kidney Renal Papillary Cell Carcinoma (TCGA)":"88.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"2.3"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm","Nucleoli","Cytosol"],"Antibody RRID":{"HPA036449":null,"HPA052726":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.65e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.80e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.58e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"}},{"Gene":"SLC6A15","Gene synonym":["FLJ10316","hv7-3","NTT73","SBAT1","V7-3"],"Ensembl":"ENSG00000072041","Gene description":"Solute carrier family 6 member 15","Uniprot":["Q9H2J7"],"Chromosome":"12","Position":"84859491-84913629","Protein class":["Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Ion transport","Neurotransmitter transport","Sodium transport","Symport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.0","retina":"14.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"73.6","Brain inhibitory neurons":"59.5","Lactotrophs":"163.9","Melanocytes":"182.7","Oligodendrocytes":"64.1","Other brain neurons":"84.5","Retinal amacrine cells":"42.2","Retinal bipolar cells":"46.7","Retinal ganglion cells":"65.7","Retinal pigment epithelial cells":"89.5","Rod photoreceptor cells":"32.9","Somatotrophs":"95.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"64.1","Neuronal cells":"84.5","Pigment cells":"182.7","Pituitary endocrine cells":"163.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"7.3","Lung Squamous Cell Carcinoma (TCGA)":"6.5","Skin Cutaneous Melanoma (TCGA)":"23.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"38.9","skin cancer":"33.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pituitary gland - Lactotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"2964464.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"25517","Protein tissue specific Intensity":{"cerebral cortex":"2551705.9"},"Antibody":["HPA008609"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":45,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA008609":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-3"}},{"Gene":"SLC6A16","Gene synonym":["NTT5"],"Ensembl":"ENSG00000063127","Gene description":"Solute carrier family 6 member 16","Uniprot":["Q9GZN6"],"Chromosome":"19","Position":"49289638-49325215","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Neurotransmitter transport","Symport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"88.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"126.8","Distal convoluted tubule cells":"63.1","Early primary spermatocytes":"179.7","Early spermatids":"101.8","Ependymal cells":"127.7","Late primary spermatocytes":"252.0","Respiratory ciliated cells":"71.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"127.7","Spermatogenic cell types":"252.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"121.9","ependymal cell":"139.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"19.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA076812":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.05e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"}},{"Gene":"SLC6A2","Gene synonym":["NAT1","NET","NET1","SLC6A5"],"Ensembl":"ENSG00000103546","Gene description":"Solute carrier family 6 member 2","Uniprot":["P23975"],"Chromosome":"16","Position":"55655988-55707645","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted membrane proteins","Transporters"],"Biological process":["Neurotransmitter transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"9.9","placenta":"6.4","skin 1":"4.4","testis":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"31.9","Epididymal efferent duct absorptive cells":"50.6","Epididymal efferent duct ciliated cells":"7.1","Extravillous trophoblasts":"19.9","Late primary spermatocytes":"16.2","Late spermatids":"9.0","Podocytes":"8.5","Syncytiotrophoblasts":"9.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"31.9","Ductal cells":"50.6","Spermatogenic cell types":"16.2","Trophoblast cells":"19.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"CGE interneuron":"3.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"6.2"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":"35","RNA brain regional specific nTPM":{"pons":"192.6"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"50","RNA cell line specific nTPM":{"Neuroblastoma":"54.0"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"CAB078195":null,"HPA004057":null,"HPA076311":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"}},{"Gene":"SLC6A4","Gene synonym":["5-HTT","HTT","OCD1","SERT1"],"Ensembl":"ENSG00000108576","Gene description":"Solute carrier family 6 member 4","Uniprot":["P31645"],"Chromosome":"17","Position":"30194319-30236002","Protein class":["FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Neurotransmitter transport","Transport"],"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"intestine":"38.0","lung":"27.2","placenta":"17.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"250.2","Enterocytes":"155.5","Migrating cytotrophoblasts":"71.7","Platelets":"63.3","Respiratory ionocytes":"35.6","Syncytiotrophoblasts":"146.7","Vascular endothelial cells":"41.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"155.5","Platelets":"63.3","Trophoblast cells":"250.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"splatter":"6.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"4.6"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"11","RNA brain regional specific nTPM":{"midbrain":"507.8","pons":"183.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"colorectal cancer":"2.5","liver cancer":"1.4"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":8,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA054723":null,"HPA071354":null,"HPA074728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC6A5","Gene synonym":["GlyT-2","GLYT2","NET1"],"Ensembl":"ENSG00000165970","Gene description":"Solute carrier family 6 member 5","Uniprot":["Q9Y345"],"Chromosome":"11","Position":"20599594-20659285","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Neurotransmitter transport","Symport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"27.6","Lactotrophs":"39.6","Late spermatids":"114.0","Oocytes":"9.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"39.6","Spermatogenic cell types":"114.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"69.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"medulla oblongata":"46.3","pons":"42.5","spinal cord":"15.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Uterine cancer":"1.9"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB079052":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC7A13","Gene synonym":["AGT-1","XAT2"],"Ensembl":"ENSG00000164893","Gene description":"Solute carrier family 7 member 13","Uniprot":["Q8TCU3"],"Chromosome":"8","Position":"86214063-86321146","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Antiport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"232","RNA tissue specific nTPM":{"kidney":"39.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Proximal tubule cells":"23.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Renal nephron cells":"23.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"1.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC7A7","Gene synonym":["LPI","y+LAT-1"],"Ensembl":"ENSG00000155465","Gene description":"Solute carrier family 7 member 7","Uniprot":["Q9UM01"],"Chromosome":"14","Position":"22773222-22829820","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Amino-acid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets","Osteoporosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"113.9","kidney":"253.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"133.6","Enterocytes":"428.4","Hofbauer cells":"219.9","Kupffer cells":"637.5","Late primary spermatocytes":"82.4","Macrophages":"128.8","Microglia":"83.1","monocytes":"198.5","Neutrophils":"120.4","Proximal tubule cells":"178.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"428.4","Mononuclear phagocytes":"637.5","Renal nephron cells":"178.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"12","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"102.4","leukocyte":"28.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"393.7","non-classical monocyte":"447.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"monocytes":"447.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036227":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"}},{"Gene":"SLC9A2","Gene synonym":["NHE2"],"Ensembl":"ENSG00000115616","Gene description":"Solute carrier family 9 member A2","Uniprot":["Q9UBY0"],"Chromosome":"2","Position":"102619553-102711355","Protein class":["Metabolic proteins","Plasma proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Ion transport","Sodium transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"19.4","stomach 1":"24.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"152.7","Enteric stem cells":"77.6","Enteric transient amplifying cells":"84.3","Foveolar cells":"150.5","Gastric chief cells":"120.1","Goblet cells":"72.8","Mucous neck cells":"191.7","Papillary tip epithelial cells":"67.3","Parietal cells":"76.0","Pituitary stem cells":"105.1","Prostatic glandular cells":"67.2","Renal collecting duct principal cells":"85.6","Renal connecting tubule cells":"81.5","Respiratory ionocytes":"86.4","Salivary duct cells":"73.7","Salivary ionocytes":"112.2","Tuft cells":"80.7","Urothelial cells":"111.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"152.7","Gastric glandular cells":"191.7","Ionocytes":"112.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"56.7","hippocampal CA4":"53.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"12.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":2,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA035121":null,"HPA035122":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"}},{"Gene":"SLC9A3R1","Gene synonym":["EBP50","NHERF","NHERF1"],"Ensembl":"ENSG00000109062","Gene description":"SLC9A3 regulator 1","Uniprot":["O14745"],"Chromosome":"17","Position":"74748628-74769353","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":["Disease variant","Osteoporosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"348.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"508.6","Esophageal apical cells":"681.6","Esophageal suprabasal cells":"576.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"681.6","Enterocytes":"508.6","Suprabasal cells":"576.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"55.5","leukocyte":"75.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"462.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3700000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":64,"Subcellular main location":["Plasma membrane","Centriolar satellite"],"Subcellular additional location":["Vesicles","Centrosome","Basal body","Cytosol","Calyx"],"Antibody RRID":{"CAB001962":null,"HPA009672":null,"HPA027247":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.98e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.49e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.30e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"}},{"Gene":"SLC9B1","Gene synonym":["NHA1","NHEDC1"],"Ensembl":"ENSG00000164037","Gene description":"Solute carrier family 9 member B1","Uniprot":["Q4ZJI4"],"Chromosome":"4","Position":"102885048-103019719","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Fertilization","Ion transport","Sodium transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"testis":"37.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"100.4","Early spermatids":"138.4","Late primary spermatocytes":"507.4","Late spermatids":"154.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"507.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035435"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol","Acrosome","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Cytosol","Acrosome"],"Subcellular additional location":["Principal piece"],"Antibody RRID":{"HPA035435":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC9C1","Gene synonym":["NHE","SLC9A10"],"Ensembl":"ENSG00000172139","Gene description":"Solute carrier family 9 member C1","Uniprot":["Q4G0N8"],"Chromosome":"3","Position":"112140898-112294227","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Differentiation","Ion transport","Sodium transport","Spermatogenesis","Transport"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"skin 1":"2.0","testis":"7.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"35.6","Distal convoluted tubule cells":"44.1","Epicardial cells":"36.4","Late primary spermatocytes":"21.0","Papillary tip epithelial cells":"67.1","Proximal tubule cells":"22.4","Renal collecting duct intercalated cells":"41.3","Renal collecting duct principal cells":"128.8","Renal connecting tubule cells":"24.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"36.4","Ductal cells":"128.8","Myocytes":"35.6","Renal nephron cells":"67.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"30.7","ependymal cell":"15.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3547","Protein tissue specific Intensity":{"ovary":"354694.6"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLC9C2","Gene synonym":["MGC43026","SLC9A11"],"Ensembl":"ENSG00000162753","Gene description":"Solute carrier family 9 member C2 (putative)","Uniprot":["Q5TAH2"],"Chromosome":"1","Position":"173500460-173603072","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Antiport","Ion transport","Sodium transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"5.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"77.9","Cone photoreceptor cells":"95.2","Endometrial ciliated cells":"35.2","Ependymal cells":"326.4","Fallopian tube ciliated cells":"44.9","Respiratory ciliated cells":"121.6","Sertoli cells":"121.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"326.4","Neuronal cells":"95.2","Reproductive supporting cells":"121.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"336.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Lung - Respiratory ciliated cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059122","HPA079529"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear speckles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"HPA059122":null,"HPA079529":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLCO1C1","Gene synonym":["OATP-F","OATP1","OATP1C1","SLC21A14"],"Ensembl":"ENSG00000139155","Gene description":"Solute carrier organic anion transporter family member 1C1","Uniprot":["Q9NYB5"],"Chromosome":"12","Position":"20695332-20753386","Protein class":["Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"19.6","choroid plexus":"16.3","pituitary gland":"7.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"315.5","Choroid plexus epithelial cells":"526.2","Pituicytes\/FSCs":"1367.0","Retinal pigment epithelial cells":"370.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Ciliated cells":"526.2","Glial cells":"1367.0","Pigment cells":"370.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"274.4","choroid plexus epithelial cell":"545.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"19","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"9.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"43","Protein cell type specific Intensity":{"Microglia and Neuropil":"4251.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLCO3A1","Gene synonym":["OATP-D","OATP3A1","SLC21A11"],"Ensembl":"ENSG00000176463","Gene description":"Solute carrier organic anion transporter family member 3A1","Uniprot":["Q9UIG8"],"Chromosome":"15","Position":"91853708-92172435","Protein class":["Metabolic proteins","Plasma proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"38.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"868.3","Neutrophils":"2014.7","Ocular epithelial cells":"693.6","Oligodendrocytes":"800.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2014.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"1067.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA066327":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.72e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.02e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":5,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA058249":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLCO6A1","Gene synonym":["CT48","MGC26949","OATP6A1","OATPY"],"Ensembl":"ENSG00000205359","Gene description":"Solute carrier organic anion transporter family member 6A1","Uniprot":["Q86UG4"],"Chromosome":"5","Position":"102371774-102499016","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"109","RNA tissue specific nTPM":{"testis":"28.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early primary spermatocytes":"95.5","Early spermatids":"147.0","Late primary spermatocytes":"379.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"55","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"379.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"2.1","oligodendrocyte":"4.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLIRP","Gene synonym":["C14orf156","DC50"],"Ensembl":"ENSG00000119705","Gene description":"SRA stem-loop interacting RNA binding protein","Uniprot":["Q9GZT3"],"Chromosome":"14","Position":"77708071-77761104","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"698.5","Hepatocytes":"876.5","Late primary spermatocytes":"950.6","Parietal cells":"878.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020291"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":31,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA020291":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.47e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"}},{"Gene":"SLIT1","Gene synonym":["MEGF4","SLIL1","Slit-1","SLIT3"],"Ensembl":"ENSG00000187122","Gene description":"Slit guidance ligand 1","Uniprot":["O75093"],"Chromosome":"10","Position":"96998038-97185959","Protein class":["Predicted secreted proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"32.7","pituitary gland":"12.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"133.9","Brain inhibitory neurons":"56.7","Early spermatids":"104.8","Late spermatids":"74.9","Other brain neurons":"66.5","Somatotrophs":"500.5","Thyrotrophs":"317.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"133.9","Pituitary endocrine cells":"500.5","Spermatogenic cell types":"104.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"17.1","Thyroid Carcinoma (TCGA)":"17.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"11.1","thyroid cancer":"8.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":9,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA006879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLITRK3","Gene synonym":["KIAA0848"],"Ensembl":"ENSG00000121871","Gene description":"SLIT and NTRK like family member 3","Uniprot":["O94933"],"Chromosome":"3","Position":"165186720-165197109","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"9.3","fallopian tube":"13.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"16.7","Brain inhibitory neurons":"19.9","Oligodendrocyte progenitor cells":"36.3","Other brain neurons":"15.0","Retinal amacrine cells":"4.8","Retinal bipolar cells":"14.3","Smooth muscle cells":"10.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Glial cells":"36.3","Neuronal cells":"19.9","Smooth muscle cells":"10.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"25","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"10.6","prostate cancer":"2.8"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"501","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"38312.8","Microglia and Neuropil":"62763.2","Neurons":"49189.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"475","Protein tissue specific Intensity":{"cerebral cortex":"27476.3","fallopian tube":"67523.4"},"Antibody":["HPA017636","HPA048042"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"450000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA017636":null,"HPA048042":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SLTM","Gene synonym":["FLJ13213","Met"],"Ensembl":"ENSG00000137776","Gene description":"SAFB like transcription modulator","Uniprot":["Q9NWH9"],"Chromosome":"15","Position":"58879050-58933679","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Transcription","Transcription regulation"],"Molecular function":["Repressor","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"20000","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":28,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA040256":null,"HPA040381":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.69e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.09e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear speckles"],"Antibody RRID":{"HPA035907":null,"HPA058120":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.18e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.38e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"SLX4","Gene synonym":["BTBD12","FANCP","KIAA1784","KIAA1987"],"Ensembl":"ENSG00000188827","Gene description":"SLX4 structure-specific endonuclease subunit","Uniprot":["Q8IY92"],"Chromosome":"16","Position":"3581181-3611606","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair"],"Molecular function":null,"Disease involvement":["Fanconi anemia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"13.5","testis":"10.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"25.2","Platelets":"74.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"74.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"27188","Protein cell type specific Intensity":{"Neurons":"2718767.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1313","Protein tissue specific Intensity":{"cerebral cortex":"131338.5"},"Antibody":["HPA066238","HPA073951"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":100,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA066238":null,"HPA073951":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.21e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"}},{"Gene":"SMAP1","Gene synonym":["FLJ13159","SMAP-1"],"Ensembl":"ENSG00000112305","Gene description":"Small ArfGAP 1","Uniprot":["Q8IYB5"],"Chromosome":"6","Position":"70667776-70862011","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"496.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"7465638.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"16322620.4"},"Antibody":["HPA030574"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":2,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA030574":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.87e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.45e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.40e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"}},{"Gene":"SMARCA2","Gene synonym":["BAF190","BRM","hBRM","hSNF2a","SNF2","SNF2L2","SNF2LA","Sth1p","SWI2"],"Ensembl":"ENSG00000080503","Gene description":"SWI\/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2","Uniprot":["P51531"],"Chromosome":"9","Position":"1980290-2193624","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Hydrolase"],"Disease involvement":["Disease variant","Hypotrichosis","Intellectual disability","Schizophrenia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Innate lymphoid cells":"690.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029981","CAB037276"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1400000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":85,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"CAB037276":null,"HPA029981":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.55e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.48e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"}},{"Gene":"SMARCA4","Gene synonym":["BAF190","BRG1","FLJ39786","hSNF2b","SNF2","SNF2-BETA","SNF2L4","SNF2LB","SWI2"],"Ensembl":"ENSG00000127616","Gene description":"SWI\/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4","Uniprot":["P51532"],"Chromosome":"19","Position":"10960932-11079426","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","Chromatin regulator","Hydrolase","Repressor","RNA-binding"],"Disease involvement":["Cancer-related genes","Deafness","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"342.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"18239547.3","Neurons":"10203987.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004208","HPA048340"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":232,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center","Nucleoli rim"],"Subcellular additional location":null,"Antibody RRID":{"CAB004208":null,"HPA048340":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.19e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.18e-6"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"SMC2","Gene synonym":["CAP-E","hCAP-E","SMC2L1"],"Ensembl":"ENSG00000136824","Gene description":"Structural maintenance of chromosomes 2","Uniprot":["O95347"],"Chromosome":"9","Position":"104094260-104141419","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA condensation","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"24.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"120.6","Endometrial ciliated cells":"142.7","Epididymal efferent duct ciliated cells":"128.4","Erythrocyte progenitors":"251.2","Megakaryocyte progenitors":"187.1","Monocyte progenitors":"185.1","Oocytes":"124.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"251.2","Megakaryocytes":"187.1","Mononuclear phagocytes":"185.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"22049846.1","Neutrophils":"21170936.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"8009872.2","ovary":"24906721.9"},"Antibody":["HPA071309"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9100","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":47,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA071309":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.85e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.44e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"}},{"Gene":"SMC6","Gene synonym":["FLJ22116","SMC6L1"],"Ensembl":"ENSG00000163029","Gene description":"Structural maintenance of chromosomes 6","Uniprot":["Q96SB8"],"Chromosome":"2","Position":"17663812-17800242","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"308.7","Choroid plexus epithelial cells":"333.1","Gonadotrophs":"563.4","Retinal pigment epithelial cells":"891.0","Sertoli cells":"530.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pigment cells":"891.0","Pituitary endocrine cells":"563.4","Reproductive supporting cells":"530.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"496.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"6943493.1","T-cells":"7959057.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"3558259.4","intestine":"2656665.4","lymphoid tissue":"2540097.3"},"Antibody":["HPA035057","CAB037186","HPA042733"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 99: Retinal pigment epithelial cells - Retinol metabolism","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB037186":null,"HPA035057":null,"HPA042733":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"}},{"Gene":"SMCO1","Gene synonym":["C3orf43","DKFZp313B0440","FLJ41923"],"Ensembl":"ENSG00000214097","Gene description":"Single-pass membrane protein with coiled-coil domains 1","Uniprot":["Q147U7"],"Chromosome":"3","Position":"196506879-196515346","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"41","RNA tissue specific nTPM":{"heart muscle":"39.4","skeletal muscle":"139.7","tongue":"99.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Myonuclei":"47.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Myocytes":"47.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skeletal muscle - Skeletal myocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"71669","Protein cell type specific Intensity":{"Capillaries":"6779063.1","Cardiomyocytes":"7554668.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA061937"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":3,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA061937":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SMDT1","Gene synonym":["C22orf32","DDDD","dJ186O1.1","EMRE"],"Ensembl":"ENSG00000183172","Gene description":"Single-pass membrane protein with aspartate rich tail 1","Uniprot":["Q9H4I9"],"Chromosome":"22","Position":"42079691-42084284","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"426.8","Parietal cells":"503.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"220","Protein cell type specific Intensity":{"Collecting ducts":"27149.8","Large ducts":"16814.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"19115.2"},"Antibody":["HPA032117","HPA060340"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":10,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA032117":null,"HPA060340":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.01e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.26e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":22,"Subcellular main location":["Nucleoli","Cytosol"],"Subcellular additional location":["Nuclear speckles","Vesicles","Basal body"],"Antibody RRID":{"HPA029350":null,"HPA076314":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.15e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.41e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"}},{"Gene":"SMG9","Gene synonym":["C19orf61","FLJ12886"],"Ensembl":"ENSG00000105771","Gene description":"SMG9 nonsense mediated mRNA decay factor","Uniprot":["Q9H0W8"],"Chromosome":"19","Position":"43727983-43754962","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Nonsense-mediated mRNA decay"],"Molecular function":null,"Disease involvement":["Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"584.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"584.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"1792438.2","T-cells":"1875917.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"12333411.0"},"Antibody":["HPA041763","HPA042096","HPA066150"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":36,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA041763":null,"HPA042096":null,"HPA066150":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.39e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"}},{"Gene":"SMIM12","Gene synonym":["C1orf212","FLJ90372"],"Ensembl":"ENSG00000163866","Gene description":"Small integral membrane protein 12","Uniprot":["Q96EX1"],"Chromosome":"1","Position":"34712737-34859755","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"146.2","Pericytes":"187.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"577987.6","Neurons":"569012.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"896066.5","heart muscle":"2883981.2"},"Antibody":["HPA065331"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":6,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA065331":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.57e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.91e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.75e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.03e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.16e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"}},{"Gene":"SMIM19","Gene synonym":["C8orf40"],"Ensembl":"ENSG00000176209","Gene description":"Small integral membrane protein 19","Uniprot":["Q96E16"],"Chromosome":"8","Position":"42541155-42555195","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA011145","HPA074830"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":4,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA011145":null,"HPA074830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.42e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.89e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.05e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"}},{"Gene":"SMIM2","Gene synonym":["C13orf44","MGC5590"],"Ensembl":"ENSG00000139656","Gene description":"Small integral membrane protein 2","Uniprot":["Q9BVW6"],"Chromosome":"13","Position":"44143150-44161257","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"22.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"52.9","Late primary spermatocytes":"46.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"52.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026891","HPA077071"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":2,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA026891":null,"HPA077071":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041686":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SMIM27","Gene synonym":["C9orf133","TOPORS-AS1"],"Ensembl":"ENSG00000235453","Gene description":"Small integral membrane protein 27","Uniprot":["A0A1B0GUW7"],"Chromosome":"9","Position":"32551144-32568621","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"422.4","Late primary spermatocytes":"363.9","Late spermatids":"233.7","Parietal cells":"143.2","Platelets":"152.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"422.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"758.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"758.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":30,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":["Cell Junctions"],"Antibody RRID":{"HPA018110":null,"HPA018125":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":93,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA019671":null,"HPA055245":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SMURF2","Gene synonym":[],"Ensembl":"ENSG00000108854","Gene description":"SMAD specific E3 ubiquitin protein ligase 2","Uniprot":["Q9HAU4"],"Chromosome":"17","Position":"64542282-64662307","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"509.3","Thymocytes":"445.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"431.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"180.1"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":84,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA071508":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.66e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.37e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"}},{"Gene":"SNAP29","Gene synonym":["CEDNIK","SNAP-29"],"Ensembl":"ENSG00000099940","Gene description":"Synaptosome associated protein 29","Uniprot":["O95721"],"Chromosome":"22","Position":"20859007-20891214","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Autophagy","Cilium biogenesis\/degradation","Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Ichthyosis","Neuropathy","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"488.0","Esophageal apical cells":"321.1","Extravillous trophoblasts":"212.7","Late primary spermatocytes":"489.1","Late spermatids":"193.4","Platelets":"211.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"321.1","Spermatogenic cell types":"489.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA031823","CAB037092","HPA056492"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"26000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":167,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"CAB037092":null,"HPA031823":null,"HPA056492":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.47e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.58e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"}},{"Gene":"SNAP47","Gene synonym":["C1orf142","SNAP-47","SVAP1"],"Ensembl":"ENSG00000143740","Gene description":"Synaptosome associated protein 47","Uniprot":["Q5SQN1"],"Chromosome":"1","Position":"227728200-227781826","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"81.6","Late spermatids":"141.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"141.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"953534.2","Microglia and Neuropil":"609374.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5882","Protein tissue specific Intensity":{"cerebral cortex":"588211.8"},"Antibody":["HPA028167"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":27,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA028167":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"}},{"Gene":"SNAP91","Gene synonym":["AP180","CALM","KIAA0656"],"Ensembl":"ENSG00000065609","Gene description":"Synaptosome associated protein 91","Uniprot":["O60641"],"Chromosome":"6","Position":"83552880-83709691","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"105.4","retina":"85.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"234.0","Brain excitatory neurons":"432.0","Brain inhibitory neurons":"342.9","Choroid plexus epithelial cells":"300.8","Cone photoreceptor cells":"492.7","Corticotrophs":"359.9","Gonadotrophs":"325.3","Lactotrophs":"378.1","Oligodendrocyte progenitor cells":"290.1","Other brain neurons":"355.7","Retinal amacrine cells":"328.8","Retinal bipolar cells":"336.8","Retinal ganglion cells":"339.9","Rod photoreceptor cells":"475.9","Somatotrophs":"322.9","Thyrotrophs":"547.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"234.0","Ciliated cells":"300.8","Glial cells":"290.1","Neuronal cells":"492.7","Pituitary endocrine cells":"547.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.8","Pancreatic Adenocarcinoma (TCGA)":"2.5","Prostate Adenocarcinoma (TCGA)":"6.3","Testicular Germ Cell Tumor (TCGA)":"2.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"24","RNA blood cell specific nTPM":{"plasmacytoid DC":"2.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"24","RNA blood lineage specific nTPM":{"dendritic cells":"2.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"11","RNA cell line specific nTPM":{"Neuroblastoma":"38.1"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Pancreas - Beta cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"193915324.1","Microglia and Neuropil":"253465641.2","Neurons":"128761736.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1","Protein tissue specific Intensity":{"cerebral cortex":"325568293.9"},"Antibody":["CAB009745","HPA029632","HPA029633"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centriolar satellite","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8500","Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"CAB009745":null,"HPA029632":null,"HPA029633":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.66e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":13,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA053145":null,"HPA066031":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.50e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA024379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"}},{"Gene":"SNCAIP","Gene synonym":["SYPH1"],"Ensembl":"ENSG00000064692","Gene description":"Synuclein alpha interacting protein","Uniprot":["Q9Y6H5"],"Chromosome":"5","Position":"122311354-122464219","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Neurodegeneration","Parkinson disease","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"16.1","endometrium 1":"18.2","ovary":"24.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"129.3","Bergmann glia":"151.9","Choroid plexus epithelial cells":"256.5","Early spermatids":"151.6","Endometrial secretory cells":"117.3","Endometrial stromal cells":"232.3","Ependymal cells":"432.2","Epicardial cells":"232.0","Lymphatic endothelial cells":"217.4","Mesothelial cells":"172.7","Pituitary stem cells":"297.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"232.0","Ciliated cells":"432.2","Endothelial cells":"217.4","Stem cells":"297.6","Stromal cells":"232.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"493.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"44","RNA blood cell specific nTPM":{"basophil":"7.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"44","RNA blood lineage specific nTPM":{"granulocytes":"7.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":15,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA064687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-3"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":6,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA059145":null,"HPA067031":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.25e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.15e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"96000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":168,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear speckles","Nuclear bodies"],"Antibody RRID":{"HPA045622":null,"HPA048499":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.19e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.83e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.18e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"}},{"Gene":"SNRPC","Gene synonym":["U1-C","Yhc1"],"Ensembl":"ENSG00000124562","Gene description":"Small nuclear ribonucleoprotein polypeptide C","Uniprot":["P09234"],"Chromosome":"6","Position":"34757505-34773857","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Ribonucleoprotein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"281.3","Hofbauer cells":"330.8","Late primary spermatocytes":"737.0","Migrating cytotrophoblasts":"278.3","Oocytes":"303.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"737.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB034338","HPA042419","HPA055490"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":402,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB034338":null,"HPA042419":null,"HPA055490":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.08e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.91e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"SNTG1","Gene synonym":["G1SYN","SYN4"],"Ensembl":"ENSG00000147481","Gene description":"Syntrophin gamma 1","Uniprot":["Q9NSN8"],"Chromosome":"8","Position":"49909789-50796692","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"4.7","lymphoid tissue":"2.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"553.1","Brain excitatory neurons":"1279.3","Brain inhibitory neurons":"1848.0","Corticotrophs":"452.2","Oligodendrocyte progenitor cells":"2990.8","Other brain neurons":"1305.6","Pancreatic islet cells":"534.2","Retinal amacrine cells":"1410.5","Retinal bipolar cells":"437.2","Retinal ganglion cells":"436.5","Somatotrophs":"864.8","Thyrotrophs":"982.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"2990.8","Neuronal cells":"1848.0","Pituitary endocrine cells":"982.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"12","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"9.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"2.1"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA072282"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA072282":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SNTG2","Gene synonym":["G2SYN","SYN5"],"Ensembl":"ENSG00000172554","Gene description":"Syntrophin gamma 2","Uniprot":["Q9NY99"],"Chromosome":"2","Position":"950849-1367613","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"156.8","Choroid plexus epithelial cells":"323.0","Corticotrophs":"614.1","Gonadotrophs":"267.0","Lymphatic endothelial cells":"386.9","Other brain neurons":"180.0","Retinal ganglion cells":"204.7","Retinal horizontal cells":"1238.1","Somatotrophs":"286.5","Vascular endothelial cells":"326.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"323.0","Endothelial cells":"386.9","Neuronal cells":"1238.1","Pituitary endocrine cells":"614.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"303.9","lower rhombic lip":"283.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"1.2"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":10,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA065258":null,"HPA077904":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SNTN","Gene synonym":["FLJ44379","S100AL"],"Ensembl":"ENSG00000188817","Gene description":"Sentan, cilia apical structure protein","Uniprot":["A6NMZ2"],"Chromosome":"3","Position":"63652675-63679020","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"fallopian tube":"162.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"67","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"547.2","Epididymal efferent duct ciliated cells":"646.8","Fallopian tube ciliated cells":"1140.3","Respiratory ciliated cells":"991.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"92","RNA single cell type group specific nCPM":{"Ciliated cells":"1140.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"ependymal cell":"16.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"21.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"1.0"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043322":null,"HPA058399":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - 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Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"75373240.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029199"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"61000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":59,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029199":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.35e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"}},{"Gene":"SNUPN","Gene synonym":["RNUT1","SNURPORTIN-1","Snurportin1"],"Ensembl":"ENSG00000169371","Gene description":"Snurportin 1","Uniprot":["O95149"],"Chromosome":"15","Position":"75598083-75626469","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transport"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant","Limb-girdle muscular dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"57.1","Late primary spermatocytes":"90.1","Late spermatids":"43.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"90.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"38909223.5","Hepatocytes":"24110665.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"22823226.6"},"Antibody":["CAB005004","HPA069478"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":18,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB005004":null,"HPA069478":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.32e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"SNW1","Gene synonym":["Bx42","FUN20","NCoA-62","Prp45","PRPF45","SKIIP","SKIP","SKIP1"],"Ensembl":"ENSG00000100603","Gene description":"SNW domain containing 1","Uniprot":["Q13573"],"Chromosome":"14","Position":"77717599-77761207","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","mRNA processing","mRNA splicing","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"305.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":310,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB009931":null,"HPA002457":null,"HPA017370":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":1,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017639":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"}},{"Gene":"SNX19","Gene synonym":["CHET8","KIAA0254"],"Ensembl":"ENSG00000120451","Gene description":"Sorting nexin 19","Uniprot":["Q92543"],"Chromosome":"11","Position":"130866250-130916479","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Exocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"292738.2","Neurons":"339807.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"1164629.1"},"Antibody":["HPA013447"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA013447":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA044566":null,"HPA073934":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"}},{"Gene":"SNX3","Gene synonym":["Grd19"],"Ensembl":"ENSG00000112335","Gene description":"Sorting nexin 3","Uniprot":["O60493"],"Chromosome":"6","Position":"108211222-108261246","Protein class":["Disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Microphthalmia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1674.5","Esophageal suprabasal cells":"942.3","Hofbauer cells":"1602.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1674.5","Mononuclear phagocytes":"1602.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"97787096.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"560000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":47,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.83e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.78e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"}},{"Gene":"SNX31","Gene synonym":["MGC39715"],"Ensembl":"ENSG00000174226","Gene description":"Sorting nexin 31","Uniprot":["Q8N9S9"],"Chromosome":"8","Position":"100572889-100663415","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"6.1","urinary bladder":"15.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"132.3","Ependymal cells":"54.0","Esophageal apical cells":"120.7","Papillary tip epithelial cells":"195.3","pDCs":"182.2","Prostatic hillock cells":"161.2","Respiratory basal cells":"229.4","Urothelial cells":"164.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"120.7","Barrier epithelial cells":"164.7","Basal cells":"229.4","dendritic cells":"182.2","Renal nephron cells":"195.3","Spermatogenic cell types":"132.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"57.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"44.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"Bladder cancer":"5.8"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"thalamus":"2.6"},"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"olfactory bulb":"1.7"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024284","HPA053466"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":1,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA024284":null,"HPA053466":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"}},{"Gene":"SOBP","Gene synonym":["FLJ10159"],"Ensembl":"ENSG00000112320","Gene description":"Sine oculis binding protein homolog","Uniprot":["A7XYQ1"],"Chromosome":"6","Position":"107490106-107661306","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"460.5","Brain excitatory neurons":"320.9","Fibro-adipogenic progenitors":"340.6","Lactotrophs":"399.9","Medullary thymic epithelial cells":"316.8","Oligodendrocyte progenitor cells":"356.4","Pituitary stem cells":"345.1","Thyrotrophs":"406.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"460.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"9.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"B-cells":"1.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4119","Protein cell type specific Intensity":{"Neurons":"411945.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"76","Protein tissue specific Intensity":{"salivary gland":"7556.6"},"Antibody":["HPA029242"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 91: Pituicytes\/FSC - Homeostasis & neuron support","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA029242":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.68e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.01e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"SOCS7","Gene synonym":["NAP4","NCKAP4"],"Ensembl":"ENSG00000274211","Gene description":"Suppressor of cytokine signaling 7","Uniprot":["O14512"],"Chromosome":"17","Position":"38351844-38405593","Protein class":["Predicted intracellular proteins"],"Biological process":["Growth regulation","Ubl conjugation pathway"],"Molecular function":["Signal transduction inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"42.7","testis":"69.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"237.6","Late spermatids":"569.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"569.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3039","Protein tissue specific Intensity":{"liver":"303874.4"},"Antibody":["HPA004475"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":23,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA004475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.90e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"}},{"Gene":"SOGA3","Gene synonym":["C6orf174","dJ403A15.3"],"Ensembl":"ENSG00000214338","Gene description":"SOGA family member 3","Uniprot":["Q5TF21"],"Chromosome":"6","Position":"127472806-127519335","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"7.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Bergmann glia":"36.3","Brain excitatory neurons":"58.4","Brain inhibitory neurons":"53.2","Oligodendrocyte progenitor cells":"35.6","Oligodendrocytes":"21.3","Other brain neurons":"57.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Glial cells":"36.3","Neuronal cells":"58.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"2.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"45.6"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 1","Prostate - Fibroblasts","Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"552776","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"52808722.5","Microglia and Neuropil":"62815009.8","Neurons":"50208941.8"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"16466481.0","intestine":"40343885.2"},"Antibody":["HPA035388","HPA035389"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":4,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035388":null,"HPA035389":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SOHLH2","Gene synonym":["bHLHe81","FLJ20449","SPATA28","TEB1"],"Ensembl":"ENSG00000120669","Gene description":"Spermatogenesis and oogenesis specific basic helix-loop-helix 2","Uniprot":["Q9NX45"],"Chromosome":"13","Position":"36168217-36214588","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Oogenesis","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"25.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"125.3","Oocytes":"409.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"13","RNA single cell type group specific nCPM":{"Oocytes":"409.9","Spermatogenic cell types":"125.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Inner root sheath cells","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"97","Protein cell type specific Intensity":{"Oocytes":"9704.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029182"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA029182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SORCS3","Gene synonym":["KIAA1059","SORCS"],"Ensembl":"ENSG00000156395","Gene description":"Sortilin related VPS10 domain containing receptor 3","Uniprot":["Q9UPU3"],"Chromosome":"10","Position":"104641290-105265242","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"7.5","pituitary gland":"2.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"223.4","Brain excitatory neurons":"191.1","Brain inhibitory neurons":"383.5","Lactotrophs":"147.2","Oligodendrocyte progenitor cells":"592.7","Other brain neurons":"180.0","Pituicytes\/FSCs":"89.1","Retinal amacrine cells":"85.1","Somatotrophs":"195.5","Thyrotrophs":"181.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"223.4","Glial cells":"592.7","Neuronal cells":"383.5","Pituitary endocrine cells":"195.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"1181.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"15","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.1","Kidney Renal Clear Cell Carcinoma (TCGA)":"4.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"5771","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"375941.7","Microglia and Neuropil":"761335.6","Neurons":"594090.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"41706","Protein tissue specific Intensity":{"cerebral cortex":"4170585.3"},"Antibody":["HPA061758"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":2,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA061758":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SOSTDC1","Gene synonym":["DAND7","DKFZp564D206","USAG1"],"Ensembl":"ENSG00000171243","Gene description":"Sclerostin domain containing 1","Uniprot":["Q6X4U4"],"Chromosome":"7","Position":"16461481-16530580","Protein class":["Predicted secreted proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"choroid plexus":"233.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"1.9","Early spermatids":"21.6","Late primary spermatocytes":"9.1","Loop of henle epithelial cells":"3.7","Proximal tubule cells":"4.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"21.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"169.4"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"27","RNA brain regional specific nTPM":{"choroid plexus":"247.9"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast myoepithelial cells","Minor Salivary Gland - Minor salivary glandular cells","Skin - Outer root sheath cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"basal ganglia":"9.2","hippocampal formation":"18.4","pons and medulla":"15.1","thalamus":"11.9"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042856"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoli","Nucleoli rim","Golgi apparatus","Vesicles"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":4,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoli","Nucleoli rim","Vesicles"],"Antibody RRID":{"HPA042856":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 61: Schwann cells & Melanocytes - Mixed function","Interactions":20,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB003171":null,"HPA068898":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SOX30","Gene synonym":[],"Ensembl":"ENSG00000039600","Gene description":"SRY-box transcription factor 30","Uniprot":["O94993"],"Chromosome":"5","Position":"157625679-157671480","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"85","RNA tissue specific nTPM":{"testis":"76.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"25.7","Early spermatids":"431.9","Epididymal efferent duct ciliated cells":"28.5","Late primary spermatocytes":"180.8","Late spermatids":"94.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"431.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"5.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"2.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"1.5"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":4,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB009382":null,"HPA006159":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SOX5","Gene synonym":["L-SOX5","MGC35153"],"Ensembl":"ENSG00000134532","Gene description":"SRY-box transcription factor 5","Uniprot":["P35711"],"Chromosome":"12","Position":"23529504-24562544","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"29.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"4038.1","Astrocytes":"2417.9","Bergmann glia":"2542.8","Endometrial stromal cells":"2054.4","Ependymal cells":"1989.1","Fibro-adipogenic progenitors":"1444.9","Melanocytes":"1416.3","Oligodendrocyte progenitor cells":"2091.0","Pituicytes\/FSCs":"1319.5","Renal collecting duct principal cells":"1356.4","Retinal ganglion cells":"1437.0","Vascular smooth muscle cells":"1533.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"4038.1","Glial cells":"2542.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"8.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"1.4","naive B-cell":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"1.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"14.5"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 17: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA060499":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"}},{"Gene":"SOX6","Gene synonym":[],"Ensembl":"ENSG00000110693","Gene description":"SRY-box transcription factor 6","Uniprot":["P35712"],"Chromosome":"11","Position":"15966449-16739591","Protein class":["Disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Transcription","Transcription regulation"],"Molecular function":["Activator","Developmental protein","DNA-binding","Repressor"],"Disease involvement":["Autism spectrum disorder","Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"25.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Corticotrophs":"1892.0","Ependymal cells":"1639.0","Lactotrophs":"969.7","Mesothelial cells":"1086.7","Myonuclei":"1739.9","Oligodendrocyte progenitor cells":"2702.9","Pituicytes\/FSCs":"1003.7","Pituitary stem cells":"1024.4","Thymic myoid cells":"1040.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1639.0","Glial cells":"2702.9","Myocytes":"1739.9","Pituitary endocrine cells":"1892.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"4041.1","oligodendrocyte precursor cell":"3252.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"20","RNA blood cell specific nTPM":{"neutrophil":"2.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"20","RNA blood lineage specific nTPM":{"granulocytes":"2.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"10.3","skin cancer":"7.6"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":20,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA001923":null,"HPA003908":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"}},{"Gene":"SP140","Gene synonym":["LYSP100-A","LYSP100-B"],"Ensembl":"ENSG00000079263","Gene description":"SP140 nuclear body protein","Uniprot":["Q13342"],"Chromosome":"2","Position":"230203110-230313215","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"intestine":"14.5","lymphoid tissue":"52.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"428.1","Innate lymphoid cells":"66.0","Microglia":"106.4","NK-cells":"153.9","Plasma cells":"190.3","T-cells":"215.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"428.1","NK-cells":"153.9","Plasma cells":"190.3","T-cells":"215.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"141.9","leukocyte":"140.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory B-cell":"97.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"lymphoma":"43.5","Myeloma":"18.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Breast - T-cells","Colon - T-cells","Heart muscle - T-cells","Kidney - T-cells","Liver - T-cells","Prostate - T-cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"6627612.1","T-cells":"2300229.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"1265476.3"},"Antibody":["HPA006162","HPA067493"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":4,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA006162":null,"HPA067493":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.14e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.66e-6"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"}},{"Gene":"SP2","Gene synonym":["KIAA0048"],"Ensembl":"ENSG00000167182","Gene description":"Sp2 transcription factor","Uniprot":["Q02086"],"Chromosome":"17","Position":"47896150-47928957","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"742501.0","Oocytes":"249703.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"226734.2"},"Antibody":["HPA003357","CAB010245"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB010245":null,"HPA003357":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"}},{"Gene":"SPA17","Gene synonym":["CT22","SP17"],"Ensembl":"ENSG00000064199","Gene description":"Sperm autoantigenic protein 17","Uniprot":["Q15506"],"Chromosome":"11","Position":"124673844-124697518","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"23.1","testis":"36.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1487.2","Late primary spermatocytes":"1868.7","Late spermatids":"3590.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3590.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"36.6","ependymal cell":"119.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Liver - Vascular endothelial cells","Lung - Respiratory ciliated cells","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"15952819.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"4140878.7"},"Antibody":["HPA037568"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":13,"Subcellular main location":["Golgi apparatus","Principal piece"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA037568":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":36,"Subcellular main location":["Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA026744":null,"HPA043297":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 2: Mucus-secreting cells - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA041927":null,"HPA061302":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.57e-4"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPACA7","Gene synonym":["C13orf28"],"Ensembl":"ENSG00000153498","Gene description":"Sperm acrosome associated 7","Uniprot":["Q96KW9"],"Chromosome":"13","Position":"112376355-112434689","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Fertilization"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"161","RNA tissue specific nTPM":{"testis":"83.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"301","RNA single cell type specific nCPM":{"Early spermatids":"1322.6","Late primary spermatocytes":"553.2","Late spermatids":"934.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"426","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1322.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"1.0"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPACDR","Gene synonym":["C7orf61","IMAGE:4839025"],"Ensembl":"ENSG00000185955","Gene description":"Sperm acrosome developmental regulator","Uniprot":["Q8IZ16"],"Chromosome":"7","Position":"100456620-100464260","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"66.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"14","RNA single cell type specific nCPM":{"Early spermatids":"556.4","Late primary spermatocytes":"436.5","Late spermatids":"448.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"556.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"35.9","oligodendrocyte":"21.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Vesicles","Acrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA060395":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"}},{"Gene":"SPAG1","Gene synonym":["CILD28","CT140","DNAAF13","FLJ32920","HSD-3.8","SP75","TPIS"],"Ensembl":"ENSG00000104450","Gene description":"Sperm associated antigen 1","Uniprot":["Q07617"],"Chromosome":"8","Position":"100157906-100259278","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Fertilization"],"Molecular function":["Hydrolase"],"Disease involvement":["Ciliopathy","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"294.0","Endometrial ciliated cells":"598.4","Ependymal cells":"413.4","Epididymal efferent duct ciliated cells":"452.4","Fallopian tube ciliated cells":"413.7","Respiratory ciliated cells":"455.8","Somatotrophs":"269.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"598.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"281.0","ependymal cell":"465.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":5,"Subcellular main location":["Primary cilium","Cytosol","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA023748":null,"HPA053682":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"}},{"Gene":"SPAG16","Gene synonym":["DKFZp666P1710","FLJ22724","PF20","WDR29"],"Ensembl":"ENSG00000144451","Gene description":"Sperm associated antigen 16","Uniprot":["Q8N0X2"],"Chromosome":"2","Position":"213284389-214410501","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"799.1","Endometrial ciliated cells":"815.8","Ependymal cells":"1818.4","Fallopian tube ciliated cells":"867.9","Lactotrophs":"1280.6","Respiratory ciliated cells":"1623.0","Somatotrophs":"1585.4","Thyrotrophs":"2509.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1818.4","Pituitary endocrine cells":"2509.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"1980.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"674","Protein cell type specific Intensity":{"Fallopian tube cells":"67373.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA037542"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane","Cytosol","Acrosome","Equatorial segment"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol","Equatorial segment"],"Subcellular additional location":["Vesicles","Plasma membrane","Acrosome"],"Antibody RRID":{"HPA037542":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"}},{"Gene":"SPAG17","Gene synonym":["CT143","FLJ34497","PF6","RP4-776P7.2"],"Ensembl":"ENSG00000155761","Gene description":"Sperm associated antigen 17","Uniprot":["Q6Q759"],"Chromosome":"1","Position":"117953590-118185228","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation","Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"25.7","testis":"14.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"722.0","Early spermatids":"285.2","Endometrial ciliated cells":"874.0","Ependymal cells":"1673.1","Epididymal efferent duct ciliated cells":"675.3","Fallopian tube ciliated cells":"683.9","Late primary spermatocytes":"257.9","Late spermatids":"648.3","Respiratory ciliated cells":"1267.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"1673.1","Spermatogenic cell types":"648.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"17","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"606.0","ependymal cell":"1720.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"56.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"1.3"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Mid piece","Principal piece"],"Subcellular additional location":["Equatorial segment"],"Antibody RRID":{"HPA028597":null,"HPA028666":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.90e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.40e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - 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Mitotic cells (Heart)","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"10651","Protein cell type specific Intensity":{"Granulosa cells":"823540.3","Oocytes":"1306751.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"112","Protein tissue specific Intensity":{"bone marrow":"11153.1"},"Antibody":["HPA022008","HPA022479","HPA024418"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Mitotic spindle","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":63,"Subcellular main location":["Nuclear bodies","Mitotic spindle"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA022008":null,"HPA022479":null,"HPA024418":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.12e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.67e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.56e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"}},{"Gene":"SPAG6","Gene synonym":["CFAP194","CT141","FAP194","PF16","Repro-SA-1"],"Ensembl":"ENSG00000077327","Gene description":"Sperm associated antigen 6","Uniprot":["O75602"],"Chromosome":"10","Position":"22345445-22454224","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"94.1","fallopian tube":"46.1","testis":"90.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"181.0","Early primary spermatocytes":"430.2","Early spermatids":"156.1","Endometrial ciliated cells":"119.2","Ependymal cells":"335.3","Epididymal efferent duct ciliated cells":"304.3","Fallopian tube ciliated cells":"307.0","Late primary spermatocytes":"801.2","Respiratory ciliated cells":"361.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"361.5","Spermatogenic cell types":"801.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"21","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"187.3","ependymal cell":"429.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"5.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"133.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"7.4","Myeloma":"6.8","Rhabdoid":"4.6"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":null,"Subcellular main location":["Calyx","Mid piece","Principal piece","End piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA038440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Primary cilium","Acrosome","Equatorial segment","End piece"],"Subcellular additional location":["Nucleoplasm","Cytosol","Principal piece"],"Antibody RRID":{"HPA068012":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.63e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"}},{"Gene":"SPATA16","Gene synonym":["NYD-SP12"],"Ensembl":"ENSG00000144962","Gene description":"Spermatogenesis associated 16","Uniprot":["Q9BXB7"],"Chromosome":"3","Position":"172889357-173141235","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"556","RNA tissue specific nTPM":{"testis":"55.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"247.3","Late primary spermatocytes":"592.3","Late spermatids":"179.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"592.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer near-projecting":"5.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037884":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":5,"Subcellular main location":["Nucleoplasm","Nucleoli","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA030099":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"SPATA2","Gene synonym":["KIAA0757","PD1","PPP1R145","tamo"],"Ensembl":"ENSG00000158480","Gene description":"Spermatogenesis associated 2","Uniprot":["Q9UM82"],"Chromosome":"20","Position":"49903391-49915529","Protein class":["Predicted intracellular proteins"],"Biological process":["Necrosis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"38.9","Late primary spermatocytes":"84.3","Late spermatids":"94.7","Syncytiotrophoblasts":"40.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"94.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":32,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA048581":null,"HPA052224":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPATA33","Gene synonym":["C16orf55","FLJ31606"],"Ensembl":"ENSG00000167523","Gene description":"Spermatogenesis associated 33","Uniprot":["Q96N06"],"Chromosome":"16","Position":"89657740-89671272","Protein class":["Predicted intracellular proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"86.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1888.7","Late primary spermatocytes":"1101.7","Late spermatids":"5815.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5815.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA045648":null,"HPA073096":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.18e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"}},{"Gene":"SPATA4","Gene synonym":["CFAP178","FAP178","SPEF1B","TSARG2"],"Ensembl":"ENSG00000150628","Gene description":"Spermatogenesis associated 4","Uniprot":["Q8NEY3"],"Chromosome":"4","Position":"176184579-176195585","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"testis":"130.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"1012.4","Late primary spermatocytes":"1446.1","Late spermatids":"643.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1446.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"36.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"basophil":"1.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"1.2"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019220","HPA030791"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA019220":null,"HPA030791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPATA45","Gene synonym":["C1orf227","LOC149643"],"Ensembl":"ENSG00000185523","Gene description":"Spermatogenesis associated 45","Uniprot":["Q537H7"],"Chromosome":"1","Position":"212830141-212847649","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"11.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"161.8","Late primary spermatocytes":"70.4","Late spermatids":"186.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"186.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"1.6"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Nuclear speckles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA049921":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPATA46","Gene synonym":["C1orf111","TEKT2BP2"],"Ensembl":"ENSG00000171722","Gene description":"Spermatogenesis associated 46","Uniprot":["Q5T0L3"],"Chromosome":"1","Position":"162373203-162376854","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"testis":"29.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"52","RNA single cell type specific nCPM":{"Early spermatids":"819.2","Late primary spermatocytes":"375.5","Late spermatids":"239.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"90","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"819.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Connecting piece","Mid piece","Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA026094":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA028234":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - 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Respiratory ciliated cells","Skeletal muscle - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"23818","Protein cell type specific Intensity":{"Fallopian tube cells":"2381790.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"220","Protein tissue specific Intensity":{"fallopian tube":"21973.6"},"Antibody":["HPA039585"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039585":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Vesicles","Primary cilium transition zone","Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA038082":null,"HPA038083":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.85e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.07e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.21e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"}},{"Gene":"SPATA9","Gene synonym":["FLJ35906","NYD-SP16"],"Ensembl":"ENSG00000145757","Gene description":"Spermatogenesis associated 9","Uniprot":["Q9BWV2"],"Chromosome":"5","Position":"95652181-95698711","Protein class":["Predicted membrane proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"22","RNA tissue specific nTPM":{"testis":"23.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"598.5","Late primary spermatocytes":"325.4","Late spermatids":"730.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"730.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte precursor cell":"34.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Kidney - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA010848","HPA076967"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA010848":null,"HPA076967":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPATS1","Gene synonym":["FLJ25442","SPATA8","SRSP1"],"Ensembl":"ENSG00000249481","Gene description":"Spermatogenesis associated serine rich 1","Uniprot":["Q496A3"],"Chromosome":"6","Position":"44342650-44380179","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"epididymis":"5.5","fallopian tube":"7.2","testis":"20.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"24.6","Ependymal cells":"10.6","Late primary spermatocytes":"22.5","Late spermatids":"25.5","Respiratory ciliated cells":"7.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"10.6","Spermatogenic cell types":"25.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"ependymal cell":"14.2"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"2.9","Testicular Germ Cell Tumor (TCGA)":"1.2","Uterine Corpus Endometrial Carcinoma (TCGA)":"2.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Neuroblastoma":"1.8","skin cancer":"6.8"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA030897":null,"HPA049722":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"}},{"Gene":"SPATS2","Gene synonym":["FLJ13117","SCR59","SPATA10"],"Ensembl":"ENSG00000123352","Gene description":"Spermatogenesis associated serine rich 2","Uniprot":["Q86XZ4"],"Chromosome":"12","Position":"49366584-49527425","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"394.3","Plasma cells":"440.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Plasma cells":"440.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"5.9","dendritic cells":"7.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":27,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA038642":null,"HPA038643":null,"HPA076823":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.37e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.17e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"}},{"Gene":"SPCS1","Gene synonym":["HSPC033","SPC1","SPC12","YJR010C-A"],"Ensembl":"ENSG00000114902","Gene description":"Signal peptidase complex subunit 1","Uniprot":["Q9Y6A9"],"Chromosome":"3","Position":"52704955-52711148","Protein class":["Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"894.3","Late primary spermatocytes":"860.6","Late spermatids":"2009.5","Plasma cells":"1111.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2009.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"56626015.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"9850471.7"},"Antibody":["HPA046091","HPA055273"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":13,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA046091":null,"HPA055273":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.09e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.94e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"SPDL1","Gene synonym":["CCDC99","FLJ20364","hSpindly"],"Ensembl":"ENSG00000040275","Gene description":"Spindle apparatus coiled-coil protein 1","Uniprot":["Q96EA4"],"Chromosome":"5","Position":"169583636-169604778","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"33.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"91.8","Early primary spermatocytes":"132.9","Erythrocyte progenitors":"52.7","Late primary spermatocytes":"108.3","Megakaryocyte progenitors":"59.3","Monocyte progenitors":"69.0","Oocytes":"87.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"69.0","Oocytes":"87.5","Spermatogenic cell types":"132.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"15600","Protein cell type specific Intensity":{"Granulosa cells":"2444484.5","Oocytes":"675573.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"129","Protein tissue specific Intensity":{"fallopian tube":"12949.8"},"Antibody":["HPA044700","HPA048146"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA044700":null,"HPA048146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.28e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.31e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.81e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.16e-7"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA035162":null,"HPA066214":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051750":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPDYE4","Gene synonym":[],"Ensembl":"ENSG00000183318","Gene description":"Speedy\/RINGO cell cycle regulator family member E4","Uniprot":["A6NLX3"],"Chromosome":"17","Position":"8747524-8758559","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"5.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"33.6","Late primary spermatocytes":"61.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"61.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":24,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA025704":null,"HPA051750":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPEF1","Gene synonym":["C20orf28","CLAMP","DKFZP434I114","SPEF1A"],"Ensembl":"ENSG00000101222","Gene description":"Sperm flagellar 1","Uniprot":["Q9Y4P9"],"Chromosome":"20","Position":"3777504-3781448","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"brain":"27.6","choroid plexus":"23.5","fallopian tube":"9.3","testis":"11.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Endometrial ciliated cells":"117.7","Ependymal cells":"87.0","Epididymal efferent duct ciliated cells":"213.6","Fallopian tube ciliated cells":"165.3","Respiratory ciliated cells":"166.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"213.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"110.2","medium spiny neuron":"79.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"9.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA050786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.81e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.41e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.93e-6"},"Cancer prognostics - 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Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"39793","Protein cell type specific Intensity":{"Fallopian tube cells":"3979301.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"12547","Protein tissue specific Intensity":{"fallopian tube":"1835466.0","heart muscle":"673973.6"},"Antibody":["HPA039606","HPA040343"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear bodies","Primary cilium","Cytosol","Flagellar centriole","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Primary cilium","Flagellar centriole"],"Subcellular additional location":["Nuclear bodies","Cytosol","Mid piece"],"Antibody RRID":{"HPA039606":null,"HPA040343":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.74e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"}},{"Gene":"SPEGNB","Gene synonym":[],"Ensembl":"ENSG00000286095","Gene description":"SPEG neighbor","Uniprot":["A0A087WV53"],"Chromosome":"2","Position":"219496131-219498287","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"2.6","skeletal muscle":"4.0","tongue":"2.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"9.9","Enterocytes":"3.4","Epididymal principal cells":"5.1","Late primary spermatocytes":"2.6","Late spermatids":"8.6","Smooth muscle cells":"8.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"9.9","Reproductive supporting cells":"5.1","Smooth muscle cells":"8.1","Spermatogenic cell types":"8.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"11.4","lower rhombic lip":"5.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"1.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Prostate - Smooth muscle cells","Skin - Smooth muscle cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPESP1","Gene synonym":["SP-ESP"],"Ensembl":"ENSG00000258484","Gene description":"Sperm equatorial segment protein 1","Uniprot":["Q6UW49"],"Chromosome":"15","Position":"68818221-68946811","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"68.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"43.7","Ependymal cells":"39.1","Late primary spermatocytes":"42.1","Renal collecting duct intercalated cells":"40.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"12.9","skin cancer":"11.0"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"37000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Acrosome","Equatorial segment"],"Subcellular additional location":["Microtubules","Cytokinetic bridge","Mitotic spindle"],"Antibody RRID":{"HPA045936":null,"HPA051040":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042499":null,"HPA048168":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.76e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPINDOC","Gene synonym":["C11orf84","SPIN-DOC"],"Ensembl":"ENSG00000168005","Gene description":"Spindlin interactor and repressor of chromatin binding","Uniprot":["Q9BUA3"],"Chromosome":"11","Position":"63813456-63827716","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Tuft cells":"34.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"SPINK2","Gene synonym":["HUSI-II"],"Ensembl":"ENSG00000128040","Gene description":"Serine peptidase inhibitor Kazal type 2","Uniprot":["P20155"],"Chromosome":"4","Position":"56809860-56821742","Protein class":["Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Serine protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"epididymis":"4955.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Epididymal principal cells":"27209.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Reproductive supporting cells":"27209.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"5.0","leukocyte":"4.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"6.4"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"choroid plexus":"3.7"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"NK-cell":"143.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"NK-cells":"143.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"12","RNA cell line specific nTPM":{"Leukemia":"23.4","lymphoma":"17.3","Myeloma":"13.7"},"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Stomach - Plasma cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB020824","HPA026813"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Acrosome","Equatorial segment"],"Secretome location":"Secreted to blood","Secretome function":"Enzyme inhibitor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":6,"Subcellular main location":["Acrosome"],"Subcellular additional location":["Equatorial segment"],"Antibody RRID":{"CAB020824":null,"HPA026813":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"}},{"Gene":"SPINT2","Gene synonym":["HAI-2","HAI2","Kop"],"Ensembl":"ENSG00000167642","Gene description":"Serine peptidase inhibitor, Kunitz type 2","Uniprot":["O43291"],"Chromosome":"19","Position":"38244035-38292615","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Protease inhibitor","Serine protease inhibitor"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"120.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"120.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"55.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Colon enterocytes","Heart muscle - Macrophages","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"912341.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2592963.5","salivary gland":"2696295.8"},"Antibody":["HPA011031","HPA011101","CAB018969","HPA074637"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"13000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":16,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB018969":null,"HPA011031":null,"HPA011101":null,"HPA074637":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.40e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"}},{"Gene":"SPIRE1","Gene synonym":["KIAA1135","spir-1"],"Ensembl":"ENSG00000134278","Gene description":"Spire type actin nucleation factor 1","Uniprot":["Q08AE8"],"Chromosome":"18","Position":"12446512-12658107","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Immunity","Innate immunity","Protein transport","Transport"],"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"395.1","Late spermatids":"491.0","Renal connecting tubule cells":"616.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"616.6","Spermatogenic cell types":"491.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"48.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"83.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"2262550.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2366506.5","intestine":"709814.6","liver":"1280505.5","salivary gland":"614667.5"},"Antibody":["HPA040737","HPA040942"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":17,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA040737":null,"HPA040942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.47e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.77e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-4"}},{"Gene":"SPOCK3","Gene synonym":["testican-3"],"Ensembl":"ENSG00000196104","Gene description":"SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3","Uniprot":["Q9BQ16"],"Chromosome":"4","Position":"166733384-167234796","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Metalloenzyme inhibitor","Metalloprotease inhibitor","Protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"127.4","parathyroid gland":"164.7","prostate":"69.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"723.3","Bergmann glia":"1252.1","Brain inhibitory neurons":"938.7","Oligodendrocyte progenitor cells":"495.8","Oligodendrocytes":"1828.7","Other brain neurons":"447.1","Retinal amacrine cells":"763.0","Retinal ganglion cells":"405.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"723.3","Glial cells":"1828.7","Neuronal cells":"938.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"MGE interneuron":"2247.9","oligodendrocyte":"2418.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"5.1","Glioblastoma Multiforme (TCGA)":"9.6","Lung Squamous Cell Carcinoma (TCGA)":"4.3","Prostate Adenocarcinoma (TCGA)":"17.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"classical monocyte":"1.2","myeloid DC":"1.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"12","RNA blood lineage specific nTPM":{"dendritic cells":"1.8","monocytes":"1.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"17.9","Rhabdoid":"26.3"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"8435","Protein cell type specific Intensity":{"Oocytes":"843540.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3287","Protein tissue specific Intensity":{"cerebral cortex":"328695.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to extracellular matrix","Secretome function":"Enzyme inhibitor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"}},{"Gene":"SPPL2B","Gene synonym":["IMP4","KIAA1532","PSL1"],"Ensembl":"ENSG00000005206","Gene description":"Signal peptide peptidase like 2B","Uniprot":["Q8TCT7"],"Chromosome":"19","Position":"2328615-2355095","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"168.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"168.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - B-cells (Spleen)","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"24962888.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"15560653.0"},"Antibody":["CAB005592","HPA039292"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":3,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"CAB005592":null,"HPA039292":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"}},{"Gene":"SPPL3","Gene synonym":["DKFZP586C1324","IMP2","MGC126674","MGC126676","MGC90402","PSL4"],"Ensembl":"ENSG00000157837","Gene description":"Signal peptide peptidase like 3","Uniprot":["Q8TCT6"],"Chromosome":"12","Position":"120762510-120904358","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)","Spleen - Endothelial cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA004194","HPA059958"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":2,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA004194":null,"HPA059958":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.02e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.69e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.86e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"SPRTN","Gene synonym":["C1orf124","DKFZP547N043","DVC1","Spartan"],"Ensembl":"ENSG00000010072","Gene description":"SprT-like N-terminal domain","Uniprot":["Q9H040"],"Chromosome":"1","Position":"231337104-231355023","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"104.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"104.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA025073"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":46,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA025073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.87e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.85e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"}},{"Gene":"SPRYD7","Gene synonym":["C13orf1","CLLD6"],"Ensembl":"ENSG00000123178","Gene description":"SPRY domain containing 7","Uniprot":["Q5W111"],"Chromosome":"13","Position":"49912702-49936490","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"177.5","Early primary spermatocytes":"105.1","Early spermatids":"106.1","Late primary spermatocytes":"283.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"177.5","Spermatogenic cell types":"283.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"2871436.1"},"Antibody":["HPA043934"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":15,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA043934":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.54e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"SPSB2","Gene synonym":["GRCC9","SSB-2"],"Ensembl":"ENSG00000111671","Gene description":"SplA\/ryanodine receptor domain and SOCS box containing 2","Uniprot":["Q99619"],"Chromosome":"12","Position":"6870935-6889358","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"42.2","Epicardial cells":"109.2","Late primary spermatocytes":"47.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"109.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"114.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA055225"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":51,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055225":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.40e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"}},{"Gene":"SPSB4","Gene synonym":["SSB-4"],"Ensembl":"ENSG00000175093","Gene description":"SplA\/ryanodine receptor domain and SOCS box containing 4","Uniprot":["Q96A44"],"Chromosome":"3","Position":"141051347-141148611","Protein class":["Predicted intracellular proteins"],"Biological process":["Biological rhythms","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"pancreas":"11.9","testis":"6.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"82.7","Early spermatids":"47.7","Fibro-adipogenic progenitors":"47.6","Gonadotrophs":"50.5","Kupffer cells":"59.4","Lactotrophs":"74.8","Late primary spermatocytes":"49.0","Late spermatids":"23.7","Megakaryocytes":"55.6","Oligodendrocyte progenitor cells":"76.0","Pancreatic acinar cells":"38.9","Renal collecting duct intercalated cells":"33.8","Somatotrophs":"29.9","Thyrotrophs":"40.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"82.7","Fibro-adipogenic progenitors":"47.6","Glial cells":"76.0","Megakaryocytes":"55.6","Mononuclear phagocytes":"59.4","Pituitary endocrine cells":"74.8","Spermatogenic cell types":"49.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"66.7","oligodendrocyte precursor cell":"96.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.8","Kidney Chromophobe (TCGA)":"3.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"13.4","testis cancer":"45.8"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Heart muscle - Cardiomyocytes","Liver - Kupffer cells","Minor Salivary Gland - Fibroblasts","Prostate - Fibroblasts","Skin - Hair cortex cells","Skin - Inner root sheath cells","Skin - Outer root sheath cells","Spleen - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA062793"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":43,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA062793":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPTA1","Gene synonym":["EL2"],"Ensembl":"ENSG00000163554","Gene description":"Spectrin alpha, erythrocytic 1","Uniprot":["P02549"],"Chromosome":"1","Position":"158610704-158686715","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell shape"],"Molecular function":["Actin capping","Actin-binding"],"Disease involvement":["Disease variant","Elliptocytosis","Hereditary hemolytic anemia","Pyropoikilocytosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"45","RNA tissue specific nTPM":{"bone marrow":"71.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Erythrocyte progenitors":"538.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Erythrocytes":"538.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"18","RNA cell line specific nTPM":{"Leukemia":"10.3"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"42000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB016193":null,"CAB037246":null,"HPA028048":null,"HPA028253":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SPTBN2","Gene synonym":["SCA5"],"Ensembl":"ENSG00000173898","Gene description":"Spectrin beta, non-erythrocytic 2","Uniprot":["O15020"],"Chromosome":"11","Position":"66682497-66744670","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin capping","Actin-binding"],"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"58.7","skin 1":"59.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"209.1","Esophageal apical cells":"110.5","Late spermatids":"136.4","Ocular epithelial cells":"152.9","Renal collecting duct intercalated cells":"139.3","Renal collecting duct principal cells":"105.8","Retinal pigment epithelial cells":"149.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"152.9","Neuronal cells":"209.1","Pigment cells":"149.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Colon - Colon enteroendocrine cells","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary gland basal cells","Prostate - Prostate glandular cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"513452539.3","Keratinocytes":"688709073.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"282554068.8"},"Antibody":["CAB009844","HPA039293","HPA043529"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"410000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 19: Cerebellar purkinje cells - Neurotransmission & signaling","Interactions":20,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB009844":null,"HPA039293":null,"HPA043529":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.77e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.53e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.00e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.79e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":5,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA037798":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SRD5A2","Gene synonym":[],"Ensembl":"ENSG00000277893","Gene description":"Steroid 5 alpha-reductase 2","Uniprot":["P31213"],"Chromosome":"2","Position":"31522480-31580938","Protein class":["Cancer-related genes","Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Differentiation","Lipid metabolism","Sexual differentiation"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets","Pseudohermaphroditism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"15","RNA tissue specific nTPM":{"epididymis":"22.2","fallopian tube":"19.2","liver":"56.8","prostate":"15.7","seminal vesicle":"17.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"96.6","Endometrial ciliated cells":"35.2","Epididymal efferent duct ciliated cells":"30.6","Epididymal principal cells":"47.3","Fallopian tube ciliated cells":"89.8","Hepatocytes":"43.2","Late spermatids":"84.7","Prostatic club cells":"144.0","Prostatic hillock cells":"38.0","Respiratory ciliated cells":"38.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"38.0","Ciliated cells":"89.8","Glandular cells":"144.0","Hepatocytes":"43.2","Reproductive supporting cells":"47.3","Spermatogenic cell types":"96.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1.2","cerebellar inhibitory":"4.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"5.2","Prostate Adenocarcinoma (TCGA)":"4.6"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"13","RNA brain regional specific nTPM":{"midbrain":"2.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Proximal tubular cells","Liver - Hepatocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"47952","Protein cell type specific Intensity":{"Hepatocytes":"4795184.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3585","Protein tissue specific Intensity":{"liver":"358495.2"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"}},{"Gene":"SRP54","Gene synonym":[],"Ensembl":"ENSG00000100883","Gene description":"Signal recognition particle 54","Uniprot":["P61011"],"Chromosome":"14","Position":"34981957-35029686","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":["Hydrolase","Ribonucleoprotein","RNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1633.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1633.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":54,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA048977":null,"HPA062044":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"}},{"Gene":"SRPK1","Gene synonym":["SFRSK1"],"Ensembl":"ENSG00000096063","Gene description":"SRSF protein kinase 1","Uniprot":["Q96SB4"],"Chromosome":"6","Position":"35832966-35921342","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Chromosome partition","Differentiation","Host-virus interaction","mRNA processing","mRNA splicing"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"437.4","Late spermatids":"890.5","Neutrophil progenitors":"707.8","Neutrophils":"2212.5","Urothelial cells":"497.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2212.5","Spermatogenic cell types":"890.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"61.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"61.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":155,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA016431":null,"HPA056486":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.74e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.01e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.17e-5"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.85e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"}},{"Gene":"SRPK2","Gene synonym":["SFRSK2"],"Ensembl":"ENSG00000135250","Gene description":"SRSF protein kinase 2","Uniprot":["P78362"],"Chromosome":"7","Position":"105110704-105399308","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Differentiation","mRNA processing","mRNA splicing"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"87.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1649.0","Late spermatids":"3787.4","Neutrophils":"2230.6","Sertoli cells":"1647.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"2230.6","Reproductive supporting cells":"1647.0","Spermatogenic cell types":"3787.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":245,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nucleoli","Acrosome","End piece"],"Antibody RRID":{"HPA015522":null,"HPA020876":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.81e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.25e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"SRPRB","Gene synonym":["APMCF1","SR-beta"],"Ensembl":"ENSG00000144867","Gene description":"SRP receptor subunit beta","Uniprot":["Q9Y5M8"],"Chromosome":"3","Position":"133784023-133825772","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"149.6","Oocytes":"142.8","Plasma cells":"206.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Stomach - Chief cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"116721193.0","Pancreatic islets":"64398256.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"100567903.2","salivary gland":"45982303.4","Stomach":"54936495.0"},"Antibody":["HPA011173"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6000","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":71,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA011173":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.02e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":31,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052783":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9400","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":56,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA042858":null,"HPA058379":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"}},{"Gene":"SRSF12","Gene synonym":["SFRS13B","SFRS19","SRrp35"],"Ensembl":"ENSG00000154548","Gene description":"Serine and arginine rich splicing factor 12","Uniprot":["Q8WXF0"],"Chromosome":"6","Position":"89095959-89118071","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"65.4","Early spermatids":"154.9","Epicardial cells":"307.0","Late primary spermatocytes":"188.4","Late spermatids":"332.3","Undifferentiated spermatogonia":"68.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"307.0","Spermatogenic cell types":"332.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"6.9"},"RNA tissue cell type enrichment":["Stomach - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"36000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":73,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Calyx","Principal piece"],"Antibody RRID":{"HPA002866":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.70e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.78e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.04e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.73e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"}},{"Gene":"SSH2","Gene synonym":["KIAA1725"],"Ensembl":"ENSG00000141298","Gene description":"Slingshot protein phosphatase 2","Uniprot":["Q76I76"],"Chromosome":"17","Position":"29625938-29930276","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Actin-binding","Hydrolase","Protein phosphatase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"92.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"1867.7","Neutrophils":"5621.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"5621.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"135.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB017189":null,"HPA057099":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.68e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"}},{"Gene":"SSMEM1","Gene synonym":["C7orf45","FLJ40316"],"Ensembl":"ENSG00000165120","Gene description":"Serine rich single-pass membrane protein 1","Uniprot":["Q8WWF3"],"Chromosome":"7","Position":"130206344-130216844","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"158","RNA tissue specific nTPM":{"testis":"30.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"471.7","Late primary spermatocytes":"453.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"237","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"471.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":92,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SSNA1","Gene synonym":["N14","NA14"],"Ensembl":"ENSG00000176101","Gene description":"SS nuclear autoantigen 1","Uniprot":["O43805"],"Chromosome":"9","Position":"137188660-137190370","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Neurogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"471.7","Esophageal basal cells":"293.1","Esophageal suprabasal cells":"357.9","Late primary spermatocytes":"426.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"471.7","Spermatogenic cell types":"426.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":19,"Subcellular main location":["Nucleoplasm","Basal body"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA074006":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.51e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"}},{"Gene":"SSR2","Gene synonym":["TLAP","TRAPB"],"Ensembl":"ENSG00000163479","Gene description":"Signal sequence receptor subunit 2","Uniprot":["P43308"],"Chromosome":"1","Position":"156009048-156020951","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"822.3","Epididymal principal cells":"695.6","Extravillous trophoblasts":"1020.9","Plasma cells":"657.6","Syncytiotrophoblasts":"678.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Trophoblast cells":"1020.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Breast - Breast glandular cells","Pituitary gland - Somatotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2706","Protein cell type specific Intensity":{"Pancreas epithelial cells":"270553.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3309","Protein tissue specific Intensity":{"bone marrow":"473284.5","pancreas":"362385.3","salivary gland":"157030.3"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"}},{"Gene":"SSUH2","Gene synonym":["C3orf32","fls485","ssu-2"],"Ensembl":"ENSG00000125046","Gene description":"Ssu-2 homolog","Uniprot":["Q9Y2M2"],"Chromosome":"3","Position":"8619386-8745040","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"6.2","testis":"5.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"125.6","Early spermatids":"140.5","Enterocytes":"20.5","Late primary spermatocytes":"50.5","Late spermatids":"113.6","Myonuclei":"29.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Myocytes":"125.6","Spermatogenic cell types":"140.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"2.8"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049777"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":130,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049777":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SSX2IP","Gene synonym":["hMsd1"],"Ensembl":"ENSG00000117155","Gene description":"SSX family member 2 interacting protein","Uniprot":["Q9Y2D8"],"Chromosome":"1","Position":"84643706-84690803","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell adhesion","Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"109.9","testis":"98.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"345.7","Early spermatids":"958.1","Late primary spermatocytes":"306.0","Late spermatids":"1688.0","Megakaryocytes":"216.4","Platelets":"540.4","Rod photoreceptor cells":"273.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"540.4","Spermatogenic cell types":"1688.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Pituitary gland - Corticotropes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"147935.8","Neurons":"170409.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"822","Protein tissue specific Intensity":{"cerebral cortex":"82204.5"},"Antibody":["HPA027306","HPA075946"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centriolar satellite","Centrosome","Basal body","Acrosome","Equatorial segment","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":125,"Subcellular main location":["Centriolar satellite","Centrosome","Basal body"],"Subcellular additional location":["Acrosome","Equatorial segment","Principal piece"],"Antibody RRID":{"HPA027306":null,"HPA075946":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.68e-2"}},{"Gene":"ST3GAL3","Gene synonym":["MRT12","SIAT6"],"Ensembl":"ENSG00000126091","Gene description":"ST3 beta-galactoside alpha-2,3-sialyltransferase 3","Uniprot":["Q11203"],"Chromosome":"1","Position":"43705824-43931165","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"82.4","tongue":"77.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Astrocytes":"115.4","Bergmann glia":"92.7","Brain excitatory neurons":"130.2","Brain inhibitory neurons":"147.1","Choroid plexus epithelial cells":"176.9","Ependymal cells":"134.7","Microglia":"120.4","Oligodendrocyte progenitor cells":"100.1","Oligodendrocytes":"101.5","Other brain neurons":"131.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"176.9","Glial cells":"120.4","Neuronal cells":"147.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"983094.5","Neurons":"1251024.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"307","Protein tissue specific Intensity":{"liver":"30736.8"},"Antibody":["HPA051102"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051102":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.74e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.69e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"ST7L","Gene synonym":["FAM4B","FLJ20284","ST7R","STLR"],"Ensembl":"ENSG00000007341","Gene description":"Suppression of tumorigenicity 7 like","Uniprot":["Q8TDW4"],"Chromosome":"1","Position":"112523514-112620825","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"33.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"222.7","Late primary spermatocytes":"218.8","Late spermatids":"529.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"529.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1554","Protein cell type specific Intensity":{"Proximal tubules":"155378.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042324","HPA075418"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA042324":null,"HPA075418":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.91e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"}},{"Gene":"ST8SIA1","Gene synonym":["SIAT8","SIAT8A"],"Ensembl":"ENSG00000111728","Gene description":"ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1","Uniprot":["Q92185"],"Chromosome":"12","Position":"22063773-22437041","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism","Sphingolipid metabolism"],"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"142.6","Astrocytes":"161.7","Bergmann glia":"486.0","Brain excitatory neurons":"138.5","Ependymal cells":"397.8","Mast cells":"217.5","M\u00fcller glia":"121.8","Myosatellite cells":"267.0","Oligodendrocyte progenitor cells":"336.0","Prostatic glandular cells":"140.9","Retinal ganglion cells":"146.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"397.8","Glial cells":"486.0","Mast cells":"217.5","Stem cells":"267.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"7.0","Skin Cutaneous Melanoma (TCGA)":"6.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"4.3","skin cancer":"10.6"},"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Skeletal muscle - Fibroblasts","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026775"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 58: Mast cells - Allergic inflammatory responses","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026775":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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unknown location","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":7,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA054518":null,"HPA057819":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"}},{"Gene":"ST8SIA5","Gene synonym":["SIAT8E"],"Ensembl":"ENSG00000101638","Gene description":"ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5","Uniprot":["O15466"],"Chromosome":"18","Position":"46667821-46759257","Protein class":["Metabolic proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"adrenal gland":"5.9","brain":"23.2","parathyroid gland":"5.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"84.4","Brain excitatory neurons":"132.8","Brain inhibitory neurons":"76.6","Cardiomyocytes":"107.9","Gonadotrophs":"32.0","Myonuclei":"32.7","Oligodendrocyte progenitor cells":"52.4","Other brain neurons":"29.7","Renal collecting duct intercalated cells":"36.7","Retinal amacrine cells":"47.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"84.4","Glial cells":"52.4","Myocytes":"107.9","Neuronal cells":"132.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"5.4","Kidney Chromophobe (TCGA)":"6.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"7.7"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1654","Protein cell type specific Intensity":{"Neurons":"165368.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA043813","HPA046771"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Midbody"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"30000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":29,"Subcellular main location":["Plasma membrane","Midbody"],"Subcellular additional location":null,"Antibody RRID":{"HPA043813":null,"HPA046771":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.59e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"STAB2","Gene synonym":["DKFZP434E0321","FEEL-2","FELL","HARE","SCARH1","STAB-2"],"Ensembl":"ENSG00000136011","Gene description":"Stabilin 2","Uniprot":["Q8WWQ8"],"Chromosome":"12","Position":"103587273-103766719","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Endocytosis"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"lymphoid tissue":"63.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Lymphatic endothelial cells":"229.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Endothelial cells":"229.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"16.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Smooth muscle cells","Liver - Sinusoid Endothelial cells","Pituitary gland - Gonadotropes","Stomach - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"135850330.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"84115723.8"},"Antibody":["HPA026871","HPA072699"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"760000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA026871":null,"HPA072699":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.98e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.48e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"STAC3","Gene synonym":["MGC2793"],"Ensembl":"ENSG00000185482","Gene description":"SH3 and cysteine rich domain 3","Uniprot":["Q96MF2"],"Chromosome":"12","Position":"57243453-57251188","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"38","RNA tissue specific nTPM":{"skeletal muscle":"2168.8","tongue":"1091.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Myonuclei":"358.7","Thymic myoid cells":"303.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Myocytes":"358.7","Stromal cells":"303.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"24.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"5.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"3.6","monocytes":"5.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Sarcoma":"168.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Adrenal gland - Macrophages","Lung - Macrophages","Spleen - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"200945","Protein cell type specific Intensity":{"Skeletal myofibers":"20094524.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"44972","Protein tissue specific Intensity":{"intestine":"6305984.5","skeletal muscle":"2688337.9"},"Antibody":["HPA039285","HPA039527"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039285":null,"HPA039527":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.15e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.63e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":72,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA035528":null,"HPA035529":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.46e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.98e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"STAMBPL1","Gene synonym":["ALMalpha","AMSH-FP","AMSH-LP","bA399O19.2","FLJ31524","KIAA1373"],"Ensembl":"ENSG00000138134","Gene description":"STAM binding protein like 1","Uniprot":["Q96FJ0"],"Chromosome":"10","Position":"88879734-88975153","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"22.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"135.0","Late primary spermatocytes":"88.7","Microglia":"148.9","Pericytes":"95.2","Vascular smooth muscle cells":"338.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"148.9","Mural cells":"338.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - T-cells","Pituitary gland - Lactotropes","Skeletal muscle - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"643271.5","Microglia and Neuropil":"632598.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"43685","Protein tissue specific Intensity":{"cerebral cortex":"6579491.3","lymphoid tissue":"2157473.3"},"Antibody":["HPA040202"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":37,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA040202":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.44e-6"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"35000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA026661":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.62e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.39e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":8,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Flagellar centriole"],"Antibody RRID":{"CAB013108":null,"HPA001860":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.11e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6300000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":148,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB017448":null,"HPA039291":null,"HPA044062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-4"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.89e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.35e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.80e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.25e-6"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"}},{"Gene":"STK11","Gene synonym":["LKB1","PJS"],"Ensembl":"ENSG00000118046","Gene description":"Serine\/threonine kinase 11","Uniprot":["Q15831"],"Chromosome":"19","Position":"1177558-1228431","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Apoptosis","Autophagy","Cell cycle","Differentiation","DNA damage","Spermatogenesis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cancer-related genes","Disease variant","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"142.1","Epicardial cells":"350.2","Late primary spermatocytes":"229.5","Late spermatids":"621.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"350.2","Spermatogenic cell types":"621.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"9.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":75,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Centrosome","Cytosol"],"Antibody RRID":{"CAB016231":null,"CAB022105":null,"HPA017254":null,"HPA067481":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":102,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Nuclear bodies","Plasma membrane","Primary cilium","Primary cilium tip","Basal body"],"Antibody RRID":{"HPA029450":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"}},{"Gene":"STK17A","Gene synonym":["DRAK1"],"Ensembl":"ENSG00000164543","Gene description":"Serine\/threonine kinase 17a","Uniprot":["Q9UEE5"],"Chromosome":"7","Position":"43582758-43650713","Protein class":["Enzymes","Plasma proteins","Predicted membrane proteins"],"Biological process":["Apoptosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"389.8","B-cells":"458.1","Neutrophils":"530.7","NK-cells":"459.5","Pancreatic duct cells":"385.0","T-cells":"479.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"365.7","central nervous system macrophage":"179.4","leukocyte":"423.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":1,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA018138":null,"HPA037979":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"STK17B","Gene synonym":["DRAK2"],"Ensembl":"ENSG00000081320","Gene description":"Serine\/threonine kinase 17b","Uniprot":["O94768"],"Chromosome":"2","Position":"196133583-196176503","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Apoptosis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"355.5","lymphoid tissue":"105.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"616.6","cDC":"761.5","Hematopoietic stem cells":"525.0","Innate lymphoid cells":"639.1","Mast cells":"789.8","Monocyte progenitors":"581.2","monocytes":"783.8","Neutrophil progenitors":"1111.7","Neutrophils":"3217.0","NK-cells":"616.6","T-cells":"869.4","Thymocytes":"653.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"3217.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"leukocyte":"552.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"74.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034858":null,"HPA073120":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.88e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"}},{"Gene":"STK31","Gene synonym":["SgK396","TDRD8"],"Ensembl":"ENSG00000196335","Gene description":"Serine\/threonine kinase 31","Uniprot":["Q9BXU1"],"Chromosome":"7","Position":"23710203-23832513","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"43","RNA tissue specific nTPM":{"testis":"59.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"36.4","Early primary spermatocytes":"130.3","Late primary spermatocytes":"306.5","Oocytes":"105.9","Retinal pigment epithelial cells":"55.4","Undifferentiated spermatogonia":"182.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"105.9","Pigment cells":"55.4","Spermatogenic cell types":"306.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"37.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"4.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"1.7","Gastric cancer":"2.2"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023194":null,"HPA072896":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"STK32C","Gene synonym":["MGC23665","PKE","YANK3"],"Ensembl":"ENSG00000165752","Gene description":"Serine\/threonine kinase 32C","Uniprot":["Q86UX6"],"Chromosome":"10","Position":"132207492-132331847","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"46.3","testis":"51.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"304.9","Epididymal principal cells":"98.0","Late primary spermatocytes":"253.2","Late spermatids":"88.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"98.0","Spermatogenic cell types":"304.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"55.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"4772458.9","Microglia and Neuropil":"7730273.1","Neurons":"4367010.0","Oocytes":"4154379.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"19913754.8"},"Antibody":["HPA017894"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA017894":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.10e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"}},{"Gene":"STK33","Gene synonym":[],"Ensembl":"ENSG00000130413","Gene description":"Serine\/threonine kinase 33","Uniprot":["Q9BYT3"],"Chromosome":"11","Position":"8391868-8594289","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"38.3","testis":"45.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1463.7","Corticotrophs":"1775.2","Endometrial ciliated cells":"1020.0","Ependymal cells":"1207.5","Fallopian tube ciliated cells":"1056.1","Pituicytes\/FSCs":"608.2","Respiratory ciliated cells":"2154.5","Somatotrophs":"668.6","Thyrotrophs":"743.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2154.5","Pituitary endocrine cells":"1775.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1194.0","ependymal cell":"1309.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"3.4","naive B-cell":"2.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"3.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"6803167.5","Pancreatic islets":"2484977.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2451707.5"},"Antibody":["HPA015742","HPA056855"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol","Flagellar centriole","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":8,"Subcellular main location":["Nucleoplasm","Flagellar centriole"],"Subcellular additional location":["Nucleoli","Cytosol","Mid piece"],"Antibody RRID":{"HPA015742":null,"HPA056855":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.51e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"}},{"Gene":"STK35","Gene synonym":["bA550O8.2","CLIK1"],"Ensembl":"ENSG00000125834","Gene description":"Serine\/threonine kinase 35","Uniprot":["Q8TDR2"],"Chromosome":"20","Position":"2101827-2177038","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"retina":"110.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"358.1","Early spermatids":"269.2","Late spermatids":"1510.5","M\u00fcller glia":"692.7","Retinal amacrine cells":"245.4","Retinal bipolar cells":"210.9","Retinal horizontal cells":"370.6","Rod photoreceptor cells":"248.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"692.7","Neuronal cells":"370.6","Spermatogenic cell types":"1510.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"224858.7","Keratinocytes":"211422.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026452","HPA051673"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 11: Muller glia cells - Retinal homeostasis","Interactions":19,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA026452":null,"HPA051673":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.97e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"}},{"Gene":"STK36","Gene synonym":["FU","KIAA1278"],"Ensembl":"ENSG00000163482","Gene description":"Serine\/threonine kinase 36","Uniprot":["Q9NRP7"],"Chromosome":"2","Position":"218672069-218702716","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Developmental protein","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Ciliopathy","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"36.2","Ependymal cells":"43.9","Respiratory ciliated cells":"49.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"49.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1069178.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"693","Protein tissue specific Intensity":{"fallopian tube":"69259.0"},"Antibody":["HPA027409","HPA027453","HPA030058"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":15,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA027409":null,"HPA027453":null,"HPA030058":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.71e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"}},{"Gene":"STK39","Gene synonym":["DCHT","SPAK"],"Ensembl":"ENSG00000198648","Gene description":"Serine\/threonine kinase 39","Uniprot":["Q9UEW8"],"Chromosome":"2","Position":"167954020-168247595","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"2338.2","Conjunctival goblet cells":"860.2","Lacrimal acinar cells":"2352.4","Pituicytes\/FSCs":"932.7","Pituitary stem cells":"861.1","Salivary ionocytes":"1567.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"2352.4","Ciliated cells":"2338.2","Ionocytes":"1567.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1901.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"6254196.9"},"Antibody":["CAB046022","HPA061803","HPA062802"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"43000","Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"CAB046022":null,"HPA061803":null,"HPA062802":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.21e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029902":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"STMN1","Gene synonym":["C1orf215","FLJ32206","Lag","LAP18","OP18","PP17","PP19","PR22","SMN"],"Ensembl":"ENSG00000117632","Gene description":"Stathmin 1","Uniprot":["P16949"],"Chromosome":"1","Position":"25884181-25906991","Protein class":["Cancer-related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"1366.8","lymphoid tissue":"1250.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"676.5","Early spermatids":"1053.3","Extravillous trophoblasts":"691.8","Granulosa cells":"978.1","Hofbauer cells":"864.3","Late primary spermatocytes":"943.7","Late spermatids":"3456.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"3456.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"425.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"dendritic cells":"425.4","T-cells":"143.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Kidney - Fibroblasts","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"240230322.6","Granulosa cells":"179799907.2","Microglia and Neuropil":"335755202.6","Neurons":"211312662.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1195011662.2"},"Antibody":["CAB010107","HPA068438"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"990000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":20,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB010107":null,"HPA068438":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.94e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.14e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"}},{"Gene":"STMN2","Gene synonym":["SCG10","SCGN10"],"Ensembl":"ENSG00000104435","Gene description":"Stathmin 2","Uniprot":["Q93045"],"Chromosome":"8","Position":"79611117-79666158","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"576.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"95.7","Brain excitatory neurons":"367.1","Brain inhibitory neurons":"191.3","Corticotrophs":"72.9","Other brain neurons":"559.9","Pancreatic islet cells":"165.2","Retinal amacrine cells":"74.3","Retinal ganglion cells":"104.3","Retinal horizontal cells":"132.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"95.7","Neuronal cells":"559.9","Pancreatic islet cells":"165.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"55.7","Pancreatic Adenocarcinoma (TCGA)":"20.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"plasmacytoid DC":"2.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"dendritic cells":"2.2"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"33","RNA cell line specific nTPM":{"Neuroblastoma":"399.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":31,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA026922":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.74e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"}},{"Gene":"STN1","Gene synonym":["bA541N10.2","FLJ22559","OBFC1"],"Ensembl":"ENSG00000107960","Gene description":"STN1 subunit of CST complex","Uniprot":["Q9H668"],"Chromosome":"10","Position":"103856806-103918332","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"13.7","Bergmann glia":"14.6","Brain inhibitory neurons":"11.9","Choroid plexus epithelial cells":"30.3","Distal convoluted tubule cells":"39.0","Ependymal cells":"16.4","Loop of henle epithelial cells":"18.3","Microglia":"20.1","Oligodendrocytes":"18.7","Other brain neurons":"14.9","Papillary tip epithelial cells":"53.3","Podocytes":"63.2","Renal collecting duct intercalated cells":"13.7","Renal collecting duct principal cells":"22.4","Renal connecting tubule cells":"24.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"30.3","Ductal cells":"24.8","Glial cells":"20.1","Neuronal cells":"14.9","Renal nephron cells":"63.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"78.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"444682.5","T-cells":"681425.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"380045.0","salivary gland":"195676.5"},"Antibody":["HPA037924","HPA037925"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA037924":null,"HPA037925":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.00e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.10e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.28e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.91e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"STPG1","Gene synonym":["C1orf201","FLJ33340","MAPO2"],"Ensembl":"ENSG00000001460","Gene description":"Sperm tail PG-rich repeat containing 1","Uniprot":["Q5TH74"],"Chromosome":"1","Position":"24356999-24416934","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"26.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"294.6","Late spermatids":"1128.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1128.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"101.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"4571","Protein cell type specific Intensity":{"Fallopian tube cells":"457134.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024301"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA024301":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.67e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA059473":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"STPG4","Gene synonym":["C2orf61","FLJ40172"],"Ensembl":"ENSG00000239605","Gene description":"Sperm-tail PG-rich repeat containing 4","Uniprot":["Q8N801"],"Chromosome":"2","Position":"47045538-47155308","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chromatin regulator","Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"65","RNA tissue specific nTPM":{"testis":"13.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"17.8","Early spermatids":"64.1","Epicardial cells":"40.9","Fibro-adipogenic progenitors":"23.2","Late primary spermatocytes":"49.5","Late spermatids":"47.1","Oocytes":"27.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"40.9","Spermatogenic cell types":"64.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"17.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"1.8"},"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA047366":null,"HPA052691":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"STRADA","Gene synonym":["LYK5","NY-BR-96","Stlk","STRAD"],"Ensembl":"ENSG00000266173","Gene description":"STE20 related adaptor alpha","Uniprot":["Q7RTN6"],"Chromosome":"17","Position":"63682336-63741986","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"76.0","Bergmann glia":"82.0","Brain excitatory neurons":"59.6","Brain inhibitory neurons":"55.8","Cardiomyocytes":"74.7","Choroid plexus epithelial cells":"73.1","Ependymal cells":"79.2","Epicardial cells":"84.1","Microglia":"86.7","Oligodendrocyte progenitor cells":"51.8","Oligodendrocytes":"97.2","Other brain neurons":"50.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"84.1","Ciliated cells":"79.2","Glial cells":"97.2","Myocytes":"74.7","Neuronal cells":"59.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":11,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA031637":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.26e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"}},{"Gene":"STRBP","Gene synonym":["FLJ11307","ILF3L","SPNR"],"Ensembl":"ENSG00000165209","Gene description":"Spermatid perinuclear RNA binding protein","Uniprot":["Q96SI9"],"Chromosome":"9","Position":"123109500-123268586","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","DNA-binding","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Ependymal cells":"648.3","Pituitary stem cells":"706.4","Respiratory ciliated cells":"516.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Stem cells":"706.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"34183693.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020651"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 32: Retina & Lymphoid tissues - Signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":40,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA020651":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.10e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.10e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"STT3B","Gene synonym":["FLJ90106","SIMP","STT3-B"],"Ensembl":"ENSG00000163527","Gene description":"STT3 oligosaccharyltransferase complex catalytic subunit B","Uniprot":["Q8TCJ2"],"Chromosome":"3","Position":"31532638-31637616","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Congenital disorder of glycosylation"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"429.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"84452880.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036448","HPA036646"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7100","Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":105,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA036448":null,"HPA036646":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.45e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"STX18","Gene synonym":["Ufe1"],"Ensembl":"ENSG00000168818","Gene description":"Syntaxin 18","Uniprot":["Q9P2W9"],"Chromosome":"4","Position":"4415742-4542346","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["ER-Golgi transport","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"112.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"392.8","Endometrial glandular cells":"452.9","Endometrial luminal cells":"463.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"392.8","Glandular cells":"452.9","Luminal cells":"463.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"12835855.0"},"Antibody":["HPA003019"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 52: Glandular & Luminal cells - Estrogen-regulated epithelial secretion","Interactions":72,"Subcellular main location":["Endoplasmic reticulum","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA003019":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.21e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.48e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"}},{"Gene":"STX2","Gene synonym":["EPIM","EPM","STX2A","STX2B","STX2C"],"Ensembl":"ENSG00000111450","Gene description":"Syntaxin 2","Uniprot":["P32856"],"Chromosome":"12","Position":"130789600-130839254","Protein class":["Cancer-related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"111.1","Choroid plexus epithelial cells":"148.2","Early spermatids":"145.9","Endometrial ciliated cells":"149.1","Fallopian tube ciliated cells":"139.8","Late primary spermatocytes":"109.8","Late spermatids":"145.4","Respiratory ciliated cells":"153.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"153.2","Spermatogenic cell types":"145.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Skin - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"341774.9","Glomeruli":"403949.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA069176","CAB079007"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Approved","Subcellular location":["Nuclear membrane","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":9,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"CAB079007":null,"HPA069176":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.27e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"}},{"Gene":"STX5","Gene synonym":["SED5","STX5A"],"Ensembl":"ENSG00000162236","Gene description":"Syntaxin 5","Uniprot":["Q13190"],"Chromosome":"11","Position":"62806860-62832051","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Congenital disorder of glycosylation","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"323.5","Syncytiotrophoblasts":"318.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":90,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA001358":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.85e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.88e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"}},{"Gene":"STX8","Gene synonym":["CARB"],"Ensembl":"ENSG00000170310","Gene description":"Syntaxin 8","Uniprot":["Q9UNK0"],"Chromosome":"17","Position":"9250471-9576591","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1546.7","Oocytes":"1174.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Oocytes":"1174.3","Spermatogenic cell types":"1546.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA001540"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":144,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001540":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.34e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"}},{"Gene":"STXBP5","Gene synonym":["LLGL3","tomosyn","tomosyn-1"],"Ensembl":"ENSG00000164506","Gene description":"Syntaxin binding protein 5","Uniprot":["Q5T5C0"],"Chromosome":"6","Position":"147204180-147391010","Protein class":["Predicted intracellular proteins"],"Biological process":["Exocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"35.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Megakaryocyte progenitors":"799.7","Megakaryocyte-Erythroid progenitors":"830.1","Neutrophil progenitors":"1587.5","Neutrophils":"1611.8","Prostatic glandular cells":"759.6","Retinal amacrine cells":"692.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1611.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"1.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"21277915.5","Microglia and Neuropil":"34021082.6","Neurons":"25338005.0","Pancreatic islets":"18643501.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"28936119.7"},"Antibody":["HPA039991","HPA049727","CAB079016"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":3,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB079016":null,"HPA039991":null,"HPA049727":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.62e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.00e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"}},{"Gene":"STYX","Gene synonym":[],"Ensembl":"ENSG00000198252","Gene description":"Serine\/threonine\/tyrosine interacting protein","Uniprot":["Q8WUJ0"],"Chromosome":"14","Position":"52730166-52774989","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"97.6","Late primary spermatocytes":"147.6","Late spermatids":"133.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"147.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"69","Protein tissue specific Intensity":{"lymphoid tissue":"6863.3"},"Antibody":["HPA040290"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":11,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA040290":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.73e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"STYXL1","Gene synonym":["DUSP24","MK-STYX"],"Ensembl":"ENSG00000127952","Gene description":"Serine\/threonine\/tyrosine interacting like 1","Uniprot":["Q9Y6J8"],"Chromosome":"7","Position":"75996338-76048004","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"170.8","Late primary spermatocytes":"116.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"170.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"121131","Protein cell type specific Intensity":{"Fallopian tube cells":"12113092.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"69251","Protein tissue specific Intensity":{"fallopian tube":"6925076.5"},"Antibody":["HPA050261"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA050261":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.81e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.97e-4"},"Cancer prognostics - 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Cardiomyocytes","Kidney - Proximal tubular cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"26008041.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"10301869.2","liver":"8784488.0"},"Antibody":["HPA026698","HPA026704","HPA026705"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Mitotic spindle","Primary cilium","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 88: Proximal tubular cells - Transmembrane transport","Interactions":null,"Subcellular main location":["Microtubules","Primary cilium"],"Subcellular additional location":["Mitotic spindle","Basal body"],"Antibody RRID":{"HPA026698":null,"HPA026704":null,"HPA026705":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.29e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.78e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - 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Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"604798.6","fallopian tube":"649634.9"},"Antibody":["HPA004890"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":37,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA004890":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.23e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"}},{"Gene":"SUGP2","Gene synonym":["KIAA0365","SFRS14"],"Ensembl":"ENSG00000064607","Gene description":"SURP and G-patch domain containing 2","Uniprot":["Q8IX01"],"Chromosome":"19","Position":"18990888-19034023","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"210571946.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"44998308.4"},"Antibody":["HPA041557","HPA061111"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA041557":null,"HPA061111":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"14000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA054728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.87e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"}},{"Gene":"SULT6B1","Gene synonym":[],"Ensembl":"ENSG00000138068","Gene description":"Sulfotransferase family 6B member 1","Uniprot":["Q6IMI4"],"Chromosome":"2","Position":"37167820-37196598","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"1.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"41.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"41.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"12","RNA blood cell specific nTPM":{"basophil":"1.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"granulocytes":"1.6"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SUN3","Gene synonym":["MGC33329","SUNC1"],"Ensembl":"ENSG00000164744","Gene description":"Sad1 and UNC84 domain containing 3","Uniprot":["Q8TAQ9"],"Chromosome":"7","Position":"47987148-48029119","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"298","RNA tissue specific nTPM":{"testis":"38.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"735.3","Late primary spermatocytes":"321.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"735.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"2.0"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA076890":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":59,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA038906":null,"HPA038907":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":34,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA024371":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"}},{"Gene":"SURF2","Gene synonym":[],"Ensembl":"ENSG00000148291","Gene description":"Surfeit 2","Uniprot":["Q15527"],"Chromosome":"9","Position":"133356550-133361158","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"102.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"418.6","Late primary spermatocytes":"470.6","Late spermatids":"1267.7","Oocytes":"294.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1267.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":12,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA044340":null,"HPA052213":null,"HPA059710":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"}},{"Gene":"SUV39H2","Gene synonym":["FLJ23414","KMT1B"],"Ensembl":"ENSG00000152455","Gene description":"SUV39H2 histone lysine methyltransferase","Uniprot":["Q9H5I1"],"Chromosome":"10","Position":"14878820-14904315","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","Cell cycle","Differentiation","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator","Methyltransferase","Repressor","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"36.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"477.2","Late primary spermatocytes":"284.2","Late spermatids":"132.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"477.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Mitotic cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045901","HPA057554"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":36,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA045901":null,"HPA057554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.26e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.67e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.58e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"SVBP","Gene synonym":["CCDC23","MGC45441"],"Ensembl":"ENSG00000177868","Gene description":"Small vasohibin binding protein","Uniprot":["Q8N300"],"Chromosome":"1","Position":"42807052-42817397","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"159.4","Early primary spermatocytes":"140.0","Early spermatids":"147.3","Late primary spermatocytes":"207.3","Oocytes":"147.4","Undifferentiated spermatogonia":"142.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"207.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA008507"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"No annotated function","CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 106: Spermatogonia - Spermatogonial differentiation","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA008507":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.70e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.45e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.22e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"SVIP","Gene synonym":["DKFZp313A2432"],"Ensembl":"ENSG00000198168","Gene description":"Small VCP interacting protein","Uniprot":["Q8NHG7"],"Chromosome":"11","Position":"22813799-22830299","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1013.9","Epididymal principal cells":"384.6","Late primary spermatocytes":"751.6","Late spermatids":"386.4","Oocytes":"386.8","Parietal cells":"452.6","Platelets":"911.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"911.3","Spermatogenic cell types":"1013.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"227.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"10714146.2","Microglia and Neuropil":"9023935.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"24641028.9"},"Antibody":["HPA039807"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039807":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.47e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"}},{"Gene":"SVOPL","Gene synonym":["MGC46715"],"Ensembl":"ENSG00000157703","Gene description":"SVOP like","Uniprot":["Q8N434"],"Chromosome":"7","Position":"138594285-138701362","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"8.6","salivary gland":"5.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"36.9","Distal convoluted tubule cells":"90.9","Ependymal cells":"64.3","Epididymal clear cells":"47.0","Loop of henle epithelial cells":"63.3","Mast cells":"36.9","Oocytes":"165.8","Renal collecting duct intercalated cells":"183.5","Renal collecting duct principal cells":"64.1","Renal connecting tubule cells":"71.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"183.5","Oocytes":"165.8","Renal nephron cells":"90.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"62.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"9.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"14","RNA blood cell specific nTPM":{"eosinophil":"2.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"14","RNA blood lineage specific nTPM":{"granulocytes":"2.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018035":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"}},{"Gene":"SWT1","Gene synonym":["C1orf26","FLJ20121","HsSwt1"],"Ensembl":"ENSG00000116668","Gene description":"SWT1 RNA endoribonuclease homolog","Uniprot":["Q5T5J6"],"Chromosome":"1","Position":"185157080-185291781","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"35.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"162.6","Late primary spermatocytes":"239.8","Neutrophils":"152.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"239.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"14.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA024214":null,"HPA027334":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.00e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.18e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"}},{"Gene":"SYCE1","Gene synonym":["bA108K14.6","C10orf94","CT76"],"Ensembl":"ENSG00000171772","Gene description":"Synaptonemal complex central element protein 1","Uniprot":["Q8N0S2"],"Chromosome":"10","Position":"133553901-133569835","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Meiosis"],"Molecular function":null,"Disease involvement":["Premature ovarian failure"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"17.7","testis":"69.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"136.9","Early primary spermatocytes":"511.1","Early spermatids":"121.4","Late primary spermatocytes":"262.2","Late spermatids":"131.3","Oocytes":"50.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"511.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"23.4"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":48,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA040208":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"}},{"Gene":"SYCE1L","Gene synonym":["MRP2"],"Ensembl":"ENSG00000205078","Gene description":"Synaptonemal complex central element protein 1 like","Uniprot":["A8MT33"],"Chromosome":"16","Position":"77199408-77213215","Protein class":["Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"17.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast myoepithelial cells":"60.3","Breast secretory cells":"167.9","Enteric transient amplifying cells":"70.4","Epididymal efferent duct absorptive cells":"71.0","Late spermatids":"86.3","Paneth cells":"112.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Secretory cells":"167.9","Secretory gland support":"112.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"22.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":null,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA062464":null,"HPA066691":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.40e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.48e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"}},{"Gene":"SYCE2","Gene synonym":["CESC1"],"Ensembl":"ENSG00000161860","Gene description":"Synaptonemal complex central element protein 2","Uniprot":["Q6PIF2"],"Chromosome":"19","Position":"12898786-12919293","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"25.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early primary spermatocytes":"417.4","Late primary spermatocytes":"118.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"16","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"417.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"30.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"2.7"},"RNA blood lineage specificity":"Lineage enhanced","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":{"NK-cells":"2.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA042080":null,"HPA062919":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.21e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"}},{"Gene":"SYCE3","Gene synonym":["C22orf41"],"Ensembl":"ENSG00000217442","Gene description":"Synaptonemal complex central element protein 3","Uniprot":["A1L190"],"Chromosome":"22","Position":"50551112-50562919","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Meiosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"53","RNA tissue specific nTPM":{"testis":"133.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"145.2","Early primary spermatocytes":"397.8","Early spermatids":"440.6","Late primary spermatocytes":"877.3","Late spermatids":"66.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"98","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"877.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"1.9","lower rhombic lip":"1.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"4.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"prostate cancer":"12.9"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047813"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":13,"Subcellular main location":["Nucleoplasm","Nucleoli","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA047813":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"}},{"Gene":"SYMPK","Gene synonym":["Pta1","SPK","SYM"],"Ensembl":"ENSG00000125755","Gene description":"Symplekin scaffold protein","Uniprot":["Q92797"],"Chromosome":"19","Position":"45815410-45863194","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell adhesion","mRNA processing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"227.4"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":54,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA041756":null,"HPA042449":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.90e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.09e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"}},{"Gene":"SYN3","Gene synonym":[],"Ensembl":"ENSG00000185666","Gene description":"Synapsin III","Uniprot":["O14994"],"Chromosome":"22","Position":"32507820-33058381","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"5.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"430.5","Brain excitatory neurons":"369.4","Brain inhibitory neurons":"557.8","Cardiomyocytes":"977.1","Corticotrophs":"362.6","Epicardial cells":"657.2","Fibroblasts":"376.7","Late spermatids":"510.6","Other brain neurons":"365.5","Pericytes":"523.1","Retinal ganglion cells":"1286.3","Thyrotrophs":"769.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"657.2","Myocytes":"977.1","Neuronal cells":"1286.3","Pituitary endocrine cells":"769.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"1835.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"22.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"3.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"B-cells":"3.2","granulocytes":"1.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"10961169.4","Microglia and Neuropil":"16701026.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"98780327.1"},"Antibody":["HPA034566"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034566":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.35e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"}},{"Gene":"SYNGR4","Gene synonym":[],"Ensembl":"ENSG00000105467","Gene description":"Synaptogyrin 4","Uniprot":["O95473"],"Chromosome":"19","Position":"48364367-48376377","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"49.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"197.9","Early spermatids":"34.8","Late primary spermatocytes":"125.8","Late spermatids":"26.9","Pancreatic islet cells":"48.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"197.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"3.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"5.9"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"18.8"},"RNA tissue cell type enrichment":["Pancreas - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":1,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA030075":null,"HPA059286":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-3"},"Cancer prognostics - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SYNJ2BP","Gene synonym":["Arip2"],"Ensembl":"ENSG00000213463","Gene description":"Synaptojanin 2 binding protein","Uniprot":["P57105"],"Chromosome":"14","Position":"70366499-70417090","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"1.6","Brain inhibitory neurons":"1.3","Enterocytes":"1.4","Epididymal clear cells":"2.0","Gastric chief cells":"2.2","Goblet cells":"1.1","Late primary spermatocytes":"1.8","Microglia":"1.5","Mucous neck cells":"1.2","Other brain neurons":"1.5","Parietal cells":"3.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"3.5","Reproductive supporting cells":"2.0","Spermatogenic cell types":"1.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":55,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA000866":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.51e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.76e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.04e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.76e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"}},{"Gene":"SYNRG","Gene synonym":["AP1GBP1","MGC104959","SYNG"],"Ensembl":"ENSG00000275066","Gene description":"Synergin gamma","Uniprot":["Q9UMZ2"],"Chromosome":"17","Position":"37514807-37609472","Protein class":["Predicted intracellular proteins"],"Biological process":["Endocytosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"117.7","Distal convoluted tubule cells":"115.2","Microglia":"139.2","Proximal tubule cells":"119.8","Renal collecting duct intercalated cells":"140.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"140.0","Glial cells":"139.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":12,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA023554":null,"HPA023555":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.95e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014141":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.10e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 96: Enteroendocrine cells - Neuropeptide signaling","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA046224":null,"HPA056602":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":26,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA004199":null,"HPA076871":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"SYT5","Gene synonym":[],"Ensembl":"ENSG00000129990","Gene description":"Synaptotagmin 5","Uniprot":["O00445"],"Chromosome":"19","Position":"55171196-55180289","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"106.0","pituitary gland":"55.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"31.9","Brain excitatory neurons":"33.2","Brain inhibitory neurons":"33.7","Gonadotrophs":"38.9","Lactotrophs":"49.4","Late spermatids":"76.9","Neuroendocrine cells":"36.0","Other brain neurons":"47.4","Pancreatic islet cells":"91.0","Somatotrophs":"24.5","Thyrotrophs":"23.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"31.9","Enteroendocrine cells":"36.0","Neuronal cells":"47.4","Pancreatic islet cells":"91.0","Pituitary endocrine cells":"49.4","Spermatogenic cell types":"76.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"28.7","Rhabdoid":"34.2"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA078390":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"55000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":6,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA045919":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TACC3","Gene synonym":["ERIC-1","ERIC1","maskin","Tacc4"],"Ensembl":"ENSG00000013810","Gene description":"Transforming acidic coiled-coil containing protein 3","Uniprot":["Q9Y6A5"],"Chromosome":"4","Position":"1712858-1745171","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"53.1","lymphoid tissue":"48.0","testis":"54.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"148.1","Early spermatids":"113.3","Erythrocyte progenitors":"117.7","Late primary spermatocytes":"224.2","Late spermatids":"154.5","Megakaryocytes":"197.8","Monocyte progenitors":"201.6","Neutrophil progenitors":"101.5","Neutrophils":"186.2","Oocytes":"179.6","Platelets":"255.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"197.8","Mononuclear phagocytes":"201.6","Neutrophils":"186.2","Oocytes":"179.6","Platelets":"255.4","Spermatogenic cell types":"224.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"28.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"91.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"373579.0","Granulosa cells":"1134507.0","Neutrophils":"387597.7","T-cells":"1302896.1"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1387","Protein tissue specific Intensity":{"bone marrow":"141808.2","lymphoid tissue":"135675.4"},"Antibody":["HPA005781","HPA006050","CAB010111","HPA022039"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Mitotic spindle","Centriolar satellite","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":39,"Subcellular main location":["Centriolar satellite","Cytosol"],"Subcellular additional location":["Golgi apparatus","Mitotic spindle","Basal body"],"Antibody RRID":{"CAB010111":null,"HPA005781":null,"HPA006050":null,"HPA022039":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.99e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.11e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.36e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.35e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.08e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.27e-8"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.77e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"}},{"Gene":"TADA3","Gene synonym":["ADA3","FLJ20221","FLJ21329","hADA3","NGG1","TADA3L"],"Ensembl":"ENSG00000171148","Gene description":"Transcriptional adaptor 3","Uniprot":["O75528"],"Chromosome":"3","Position":"9779967-9793011","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"163.1","Megakaryocytes":"222.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"222.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":72,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA042250":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.67e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.47e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"}},{"Gene":"TAF10","Gene synonym":["TAF2A","TAF2H","TAFII30"],"Ensembl":"ENSG00000166337","Gene description":"TATA-box binding protein associated factor 10","Uniprot":["Q12962"],"Chromosome":"11","Position":"6606294-6612539","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"156.2","Late spermatids":"302.1","Megakaryocytes":"204.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"204.0","Myocytes":"156.2","Spermatogenic cell types":"302.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":52,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB022405":null,"HPA004148":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.02e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.95e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.89e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"}},{"Gene":"TAF1L","Gene synonym":[],"Ensembl":"ENSG00000122728","Gene description":"TATA-box binding protein associated factor 1 like","Uniprot":["Q8IZX4"],"Chromosome":"9","Position":"32629454-32635669","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"retina":"1.5","testis":"1.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"2.7","Early spermatids":"8.6","Late spermatids":"1.2","Podocytes":"1.3","Proximal tubule cells":"1.6","Renal collecting duct intercalated cells":"1.1","Renal connecting tubule cells":"1.2","Retinal bipolar cells":"11.0","Undifferentiated spermatogonia":"1.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Neuronal cells":"11.0","Spermatogenic cell types":"8.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA056605":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TAF4","Gene synonym":["TAF2C","TAF2C1","TAF4A","TAFII130","TAFII135"],"Ensembl":"ENSG00000130699","Gene description":"TATA-box binding protein associated factor 4","Uniprot":["O00268"],"Chromosome":"20","Position":"61953469-62065881","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Proximal tubule cells":"54.5","Renal collecting duct intercalated cells":"56.5"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":37,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Endoplasmic reticulum","Cytosol"],"Antibody RRID":{"CAB031484":null,"HPA008599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.98e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.57e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"}},{"Gene":"TAF9","Gene synonym":["AD-004","CGI-137","MGC1603","MGC3647","MGC5067","TAF2G","TAFII31","TAFII32","TAFIID32"],"Ensembl":"ENSG00000273841","Gene description":"TATA-box binding protein associated factor 9","Uniprot":["Q16594"],"Chromosome":"5","Position":"69362026-69370013","Protein class":["Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"2.7","Epicardial cells":"2.3","Epididymal clear cells":"2.0","Erythrocyte progenitors":"2.7","Late primary spermatocytes":"3.1","Late spermatids":"5.6","Pancreatic acinar cells":"2.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"5.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":70,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA028930":null,"HPA053429":null,"HPA058961":null,"HPA072658":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.06e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.21e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"}},{"Gene":"TAFA1","Gene synonym":["FAM19A1","TAFA-1"],"Ensembl":"ENSG00000183662","Gene description":"TAFA chemokine like family member 1","Uniprot":["Q7Z5A9"],"Chromosome":"3","Position":"68004247-68545621","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"18.3","choroid plexus":"6.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"329.7","Astrocytes":"137.2","Brain excitatory neurons":"932.5","Brain inhibitory neurons":"109.1","Oligodendrocyte progenitor cells":"561.1","Other brain neurons":"161.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"329.7","Glial cells":"561.1","Neuronal cells":"932.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"2599.0","mammillary body":"3057.2"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"1.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"gdT-cell":"7.6","MAIT T-cell":"4.8","memory CD4 T-cell":"5.6","memory CD8 T-cell":"4.4","naive CD4 T-cell":"4.1","naive CD8 T-cell":"5.4","T-reg":"2.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"T-cells":"7.6"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013407":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TAFA2","Gene synonym":["FAM19A2","TAFA-2"],"Ensembl":"ENSG00000198673","Gene description":"TAFA chemokine like family member 2","Uniprot":["Q8N3H0"],"Chromosome":"12","Position":"61708273-62279150","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"18.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"696.4","Brain inhibitory neurons":"467.6","Early spermatids":"396.3","Epicardial cells":"591.3","Hematopoietic stem cells":"2115.6","Megakaryocyte-Erythroid progenitors":"650.6","Neutrophil progenitors":"752.8","Neutrophils":"755.1","Oligodendrocyte progenitor cells":"691.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"691.8","Neuronal cells":"696.4","Neutrophils":"755.1","Stem cells":"2115.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"31.7","neutrophil":"12.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"31.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"3.7","Leukemia":"5.2"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"}},{"Gene":"TAFA3","Gene synonym":["FAM19A3","TAFA-3"],"Ensembl":"ENSG00000184599","Gene description":"TAFA chemokine like family member 3","Uniprot":["Q7Z5A8"],"Chromosome":"1","Position":"112718905-112727235","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"12.9","retina":"42.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"31.9","Cone photoreceptor cells":"105.6","Early spermatids":"13.2","Late primary spermatocytes":"22.8","Late spermatids":"26.2","M\u00fcller glia":"10.9","Myonuclei":"17.6","Retinal bipolar cells":"49.1","Retinal pigment epithelial cells":"29.8","Rod photoreceptor cells":"9.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"31.9","Neuronal cells":"105.6","Pigment cells":"29.8","Spermatogenic cell types":"26.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Rhabdoid":"14.0","skin cancer":"4.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA055927":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TAPT1","Gene synonym":["FLJ90013"],"Ensembl":"ENSG00000169762","Gene description":"Transmembrane anterior posterior transformation 1","Uniprot":["Q6NXT6"],"Chromosome":"4","Position":"16160505-16227410","Protein class":["Disease related genes","Human disease related genes","Predicted membrane proteins"],"Biological process":["Chondrogenesis","Cilium biogenesis\/degradation","Differentiation","Host-virus interaction","Osteogenesis"],"Molecular function":["Developmental protein","Receptor"],"Disease involvement":["Ciliopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"299.4","Myonuclei":"204.1","Neutrophil progenitors":"230.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"299.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":4,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA042567":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.72e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.80e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"}},{"Gene":"TAS1R1","Gene synonym":["GPR70","T1R1","TR1"],"Ensembl":"ENSG00000173662","Gene description":"Taste 1 receptor member 1","Uniprot":["Q7RTX1"],"Chromosome":"1","Position":"6555307-6579755","Protein class":["G-protein coupled receptors","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Sensory transduction","Taste"],"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"11.6","Endometrial glandular cells":"12.8","Endometrial luminal cells":"30.6","Endometrial secretory cells":"17.2","Epididymal basal cells":"12.5","Late spermatids":"30.2","M\u00fcller glia":"10.9","Myonuclei":"19.2","Thymic myoid cells":"9.5","Tuft cells":"11.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Luminal cells":"30.6","Myocytes":"19.2","Secretory cells":"17.2","Spermatogenic cell types":"30.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"4.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Myeloma":"1.7"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034579":null,"HPA034580":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA030824":null,"HPA030825":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.16e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.37e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"}},{"Gene":"TAT","Gene synonym":[],"Ensembl":"ENSG00000198650","Gene description":"Tyrosine aminotransferase","Uniprot":["P17735"],"Chromosome":"16","Position":"71565660-71577092","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Phenylalanine catabolism","Tyrosine catabolism"],"Molecular function":["Aminotransferase","Transferase"],"Disease involvement":["Disease variant","Intellectual disability","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"liver":"1188.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"30","RNA single cell type specific nCPM":{"Hepatocytes":"5253.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"30","RNA single cell type group specific nCPM":{"Hepatocytes":"5253.2"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"1.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"253.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"1.4"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 93: Hepatocytes - Bile production & excretion","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TBATA","Gene synonym":["C10orf27","FLJ32820","spatial"],"Ensembl":"ENSG00000166220","Gene description":"Thymus, brain and testes associated","Uniprot":["Q96M53"],"Chromosome":"10","Position":"70771238-70785401","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"lymphoid tissue":"119.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"148.9","Late spermatids":"545.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"142","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"545.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"19","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"2.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TBC1D1","Gene synonym":["KIAA1108","TBC","TBC1"],"Ensembl":"ENSG00000065882","Gene description":"TBC1 domain family member 1","Uniprot":["Q86TI0"],"Chromosome":"4","Position":"37891084-38139175","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"996.1","Podocytes":"426.1","Renal collecting duct intercalated cells":"835.4","Salivary ionocytes":"464.7","Vascular smooth muscle cells":"621.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"835.4","Neutrophils":"996.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"793.3"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"243.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":51,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA041816":null,"HPA058158":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.38e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.74e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.30e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.87e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.68e-4"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"}},{"Gene":"TBC1D10B","Gene synonym":["DKFZP434P1750","EPI64B","FLJ13130","Rab27A-GAPbeta"],"Ensembl":"ENSG00000169221","Gene description":"TBC1 domain family member 10B","Uniprot":["Q4KMP7"],"Chromosome":"16","Position":"30357102-30370494","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"57.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048894":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA038277":null,"HPA038645":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":22,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA013388":null,"HPA015592":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"}},{"Gene":"TBC1D26","Gene synonym":["MGC51025"],"Ensembl":"ENSG00000214946","Gene description":"TBC1 domain family member 26","Uniprot":[],"Chromosome":"17","Position":"15732247-15746162","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"15.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"6.6","Brain inhibitory neurons":"8.1","Early spermatids":"2.3","Late primary spermatocytes":"1.5","Oligodendrocytes":"1.1","Other brain neurons":"1.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"8.1","Spermatogenic cell types":"2.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"17.7","medium spiny neuron":"19.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA050044":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 101: Choroid plexus epithelial cells - Ion transport","Interactions":1,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA039772":null,"HPA040043":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":4,"Subcellular main location":["Centrosome","Basal body"],"Subcellular additional location":null,"Antibody RRID":{"HPA023710":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.41e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"}},{"Gene":"TBC1D32","Gene synonym":["bA57L9.1","BROMI","C6orf170","C6orf171","dJ310J6.1","FLJ30899","FLJ34235"],"Ensembl":"ENSG00000146350","Gene description":"TBC1 domain family member 32","Uniprot":["Q96NH3"],"Chromosome":"6","Position":"121079494-121334745","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"6.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gonadotrophs":"321.2","Lactotrophs":"355.8","Rod photoreceptor cells":"614.9","Somatotrophs":"389.9","Thyrotrophs":"313.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"614.9","Pituitary endocrine cells":"389.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":6,"Subcellular main location":["Mitochondria","Cytosol"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA013413":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":141,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA045797":null,"HPA060211":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"}},{"Gene":"TBL2","Gene synonym":["DKFZP43N024","WBSCR13","WS-betaTRP"],"Ensembl":"ENSG00000106638","Gene description":"Transducin beta like 2","Uniprot":["Q9Y4P3"],"Chromosome":"7","Position":"73567537-73578791","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Williams-Beuren syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"12.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"361.6","Late primary spermatocytes":"748.7","Late spermatids":"764.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"764.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"94420054.8","Pancreatic islets":"26106896.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"46111775.2","salivary gland":"17861022.7","Stomach":"30683161.3"},"Antibody":["HPA007477","HPA051533"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":36,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA007477":null,"HPA051533":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.44e-5"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.72e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"}},{"Gene":"TBL3","Gene synonym":["SAZD","UTP13"],"Ensembl":"ENSG00000183751","Gene description":"Transducin beta like 3","Uniprot":["Q12788"],"Chromosome":"16","Position":"1972053-1982929","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"123.5","Esophageal apical cells":"252.1","Late spermatids":"107.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"252.1","Spermatogenic cell types":"123.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"12276343.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2589855.9"},"Antibody":["HPA042562","HPA055695"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":"Supported","Reliability (IF)":"Enhanced","Subcellular location":["Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":44,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA042562":null,"HPA055695":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.41e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.88e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"}},{"Gene":"TBP","Gene synonym":["GTF2D1","SCA17","TBP1","TFIID"],"Ensembl":"ENSG00000112592","Gene description":"TATA-box binding protein","Uniprot":["P20226"],"Chromosome":"6","Position":"170554302-170572870","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Disease variant","Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"152.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"152.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"2185484.6","T-cells":"1793865.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"946","Protein tissue specific Intensity":{"lymphoid tissue":"94563.6"},"Antibody":["CAB009442","HPA049805","HPA070500"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":179,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB009442":null,"HPA049805":null,"HPA070500":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.17e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.61e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"TBPL1","Gene synonym":["STUD","TLF","TLP","TRF2"],"Ensembl":"ENSG00000028839","Gene description":"TATA-box binding protein like 1","Uniprot":["P62380"],"Chromosome":"6","Position":"133952170-133990432","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"118.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"253.0","Late primary spermatocytes":"1117.5","Platelets":"217.5","Syncytiotrophoblasts":"324.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1117.5","Trophoblast cells":"324.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"1747712.1","Neurons":"2533583.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"288","Protein tissue specific Intensity":{"fallopian tube":"13253.8","lymphoid tissue":"44337.2"},"Antibody":["HPA071810","HPA071813"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":16,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA071810":null,"HPA071813":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.23e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.02e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.85e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"}},{"Gene":"TBRG4","Gene synonym":["Cpr2","FASTKD4","H_TD2522F11.8","KIAA0948"],"Ensembl":"ENSG00000136270","Gene description":"Transforming growth factor beta regulator 4","Uniprot":["Q969Z0"],"Chromosome":"7","Position":"45100100-45112047","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"80.4","Late primary spermatocytes":"103.4","Migrating cytotrophoblasts":"94.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"3721810.0"},"Antibody":["HPA020582","HPA050430"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"32000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":27,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA020582":null,"HPA050430":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.54e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.22e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":10,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA052245":null,"HPA053713":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"}},{"Gene":"TBX4","Gene synonym":[],"Ensembl":"ENSG00000121075","Gene description":"T-box transcription factor 4","Uniprot":["P57082"],"Chromosome":"17","Position":"61452404-61485110","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lung":"30.9","placenta":"19.8","prostate":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"3.9","Cone photoreceptor cells":"2.1","Early spermatids":"8.7","Epicardial cells":"2.3","Fibroblasts":"2.5","Late spermatids":"28.5","Pericytes":"8.6","Smooth muscle cells":"4.3","Vascular smooth muscle cells":"3.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Mural cells":"8.6","Spermatogenic cell types":"28.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"2.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Gastric cancer":"4.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB032413":null,"HPA044457":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.43e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TCEA2","Gene synonym":["TFIIS"],"Ensembl":"ENSG00000171703","Gene description":"Transcription elongation factor A2","Uniprot":["Q15560"],"Chromosome":"20","Position":"64049836-64072347","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"189.2","Late spermatids":"259.5","Megakaryocytes":"197.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"197.8","Spermatogenic cell types":"259.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":95,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Basal body"],"Antibody RRID":{"HPA043836":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"}},{"Gene":"TCEANC2","Gene synonym":["C1orf83","FLJ32112"],"Ensembl":"ENSG00000116205","Gene description":"Transcription elongation factor A N-terminal and central domain containing 2","Uniprot":["Q96MN5"],"Chromosome":"1","Position":"54053584-54112519","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"58.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"291","Protein cell type specific Intensity":{"Fallopian tube cells":"25814.3","T-cells":"32443.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046918"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA046918":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.78e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.60e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"}},{"Gene":"TCF20","Gene synonym":["AR1","SPBP"],"Ensembl":"ENSG00000100207","Gene description":"Transcription factor 20","Uniprot":["Q9UGU0"],"Chromosome":"22","Position":"42160013-42343616","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"101.4","Brain inhibitory neurons":"134.1","Cone photoreceptor cells":"101.4","Early spermatids":"97.7","Oligodendrocytes":"100.6","Other brain neurons":"149.1","Proximal tubule cells":"126.6","Renal collecting duct intercalated cells":"107.0","Renal connecting tubule cells":"102.8","Retinal bipolar cells":"109.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"107.0","Neuronal cells":"149.1","Renal nephron cells":"126.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"4025843.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"3456053.2"},"Antibody":["CAB017849","HPA036786"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"CAB017849":null,"HPA036786":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.51e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"}},{"Gene":"TCFL5","Gene synonym":["bHLHe82","CHA","E2BP-1","Figlb"],"Ensembl":"ENSG00000101190","Gene description":"Transcription factor like 5","Uniprot":["Q9UL49"],"Chromosome":"20","Position":"62841005-62861822","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"65.8","testis":"69.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"82.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"82.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA055223","HPA076419"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA055223":null,"HPA076419":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"}},{"Gene":"TCP1","Gene synonym":["CCT1","Ccta","D6S230E"],"Ensembl":"ENSG00000120438","Gene description":"T-complex 1","Uniprot":["P17987"],"Chromosome":"6","Position":"159778498-159789703","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone","Hydrolase"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"525.6","Late spermatids":"1013.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1013.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017460","HPA027337","HPA031082"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3700000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":195,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB017460":null,"HPA027337":null,"HPA031082":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.80e-5"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.60e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.13e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.50e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.55e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"}},{"Gene":"TCP10L","Gene synonym":["PRED77"],"Ensembl":"ENSG00000242220","Gene description":"T-complex 10 like","Uniprot":["Q8TDR4"],"Chromosome":"21","Position":"32497967-32587373","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Repressor"],"Disease involvement":["Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"142.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"50.5","Bergmann glia":"88.1","Brain excitatory neurons":"64.8","Brain inhibitory neurons":"66.0","Choroid plexus epithelial cells":"54.0","Early spermatids":"22.1","Ependymal cells":"141.2","Late spermatids":"30.9","Oligodendrocyte progenitor cells":"23.2","Oligodendrocytes":"42.8","Other brain neurons":"26.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"141.2","Glial cells":"88.1","Neuronal cells":"66.0","Spermatogenic cell types":"30.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"7.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enriched","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":"7","RNA pig brain regional specific nTPM":{"basal ganglia":"1.1"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2796","Protein cell type specific Intensity":{"Fallopian tube cells":"279630.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044709"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":35,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044709":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.01e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.30e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"}},{"Gene":"TCP11","Gene synonym":["D6S230E","FPPR","KIAA0229"],"Ensembl":"ENSG00000124678","Gene description":"T-complex 11","Uniprot":["Q8WWU5"],"Chromosome":"6","Position":"35118071-35148610","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"346","RNA tissue specific nTPM":{"testis":"327.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"11780.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"442","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"11780.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"6.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA048311":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.84e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-6"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":42,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA005769":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.91e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.62e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"}},{"Gene":"TCTE1","Gene synonym":["D6S46","DRC5","FAP155","MGC33600"],"Ensembl":"ENSG00000146221","Gene description":"T-complex-associated-testis-expressed 1","Uniprot":["Q5JU00"],"Chromosome":"6","Position":"44278734-44297698","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"7.9","fallopian tube":"13.6","testis":"28.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"181.5","Late spermatids":"534.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"534.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"27.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"2.6"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"33047","Protein cell type specific Intensity":{"Fallopian tube cells":"3304655.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"7508","Protein tissue specific Intensity":{"fallopian tube":"750829.1"},"Antibody":["HPA031739"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Cytosol","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Vesicles","Mid piece"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA031739":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"}},{"Gene":"TDP1","Gene synonym":["FLJ11090","SCAN1"],"Ensembl":"ENSG00000042088","Gene description":"Tyrosyl-DNA phosphodiesterase 1","Uniprot":["Q9NUW8"],"Chromosome":"14","Position":"89954939-90044764","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["Exonuclease","Hydrolase","Nuclease"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"165.8","Late primary spermatocytes":"100.2","Oocytes":"78.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"165.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Mitotic cells (Skin)","Spleen - B-cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"1311655.7","Neurons":"1271392.4","T-cells":"1734406.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"746521.5","lymphoid tissue":"310630.3"},"Antibody":["HPA071317"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":27,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA071317":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.45e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":null,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA054327":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.26e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TDRD7","Gene synonym":["PCTAIRE2BP"],"Ensembl":"ENSG00000196116","Gene description":"Tudor domain containing 7","Uniprot":["Q8NHU6"],"Chromosome":"9","Position":"97412096-97496125","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["RNA-binding"],"Disease involvement":["Cataract","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"58.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Rod photoreceptor cells":"214.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"214.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":9,"Subcellular main location":["Cytoplasmic bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB020800":null,"HPA022250":null,"HPA024529":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"}},{"Gene":"TDRKH","Gene synonym":["TDRD2"],"Ensembl":"ENSG00000182134","Gene description":"Tudor and KH domain containing","Uniprot":["Q9Y2W6"],"Chromosome":"1","Position":"151770107-151791416","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","RNA-mediated gene silencing","Spermatogenesis"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"28.3","testis":"20.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"46.9","Early primary spermatocytes":"61.2","Early spermatids":"38.9","Late primary spermatocytes":"46.6","Late spermatids":"112.3","Oocytes":"82.9","Platelets":"46.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"82.9","Platelets":"46.7","Secretory cells":"46.9","Spermatogenic cell types":"112.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":12,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA016419":null,"HPA019625":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.18e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"TEAD2","Gene synonym":["ETF","TEF-4","TEF4"],"Ensembl":"ENSG00000074219","Gene description":"TEA domain transcription factor 2","Uniprot":["Q15562"],"Chromosome":"19","Position":"49340595-49362457","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"42.0","Decidual stromal cells":"40.5","Early spermatids":"85.0","Extravillous trophoblasts":"34.6","Late primary spermatocytes":"35.8","Late spermatids":"38.2","Lymphatic endothelial cells":"48.4","Pericytes":"35.2","Vascular endothelial cells":"44.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"85.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"19.4","pericyte":"30.2","vascular associated smooth muscle cell":"19.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"22","RNA blood cell specific nTPM":{"memory B-cell":"1.7","naive B-cell":"2.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"27","RNA blood lineage specific nTPM":{"B-cells":"2.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA066292":null,"HPA069963":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.41e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"}},{"Gene":"TECPR2","Gene synonym":["KIAA0329"],"Ensembl":"ENSG00000196663","Gene description":"Tectonin beta-propeller repeat containing 2","Uniprot":["O15040"],"Chromosome":"14","Position":"102362941-102502477","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":["Hereditary spastic paraplegia","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Neutrophils":"1480.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neutrophils":"1480.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"neutrophil":"7.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"14","RNA blood lineage specific nTPM":{"granulocytes":"7.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"22009378.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"4599613.3","ovary":"9604510.2"},"Antibody":["HPA000658"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Centrosome"],"Antibody RRID":{"HPA000658":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.35e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.49e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.00e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"TECR","Gene synonym":["GPSN2","MRT14","SC2","TER"],"Ensembl":"ENSG00000099797","Gene description":"Trans-2,3-enoyl-CoA reductase","Uniprot":["Q9NZ01"],"Chromosome":"19","Position":"14517085-14565980","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":["Fatty acid biosynthesis","Fatty acid metabolism","Lipid biosynthesis","Lipid metabolism","Sphingolipid metabolism"],"Molecular function":["Oxidoreductase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1246.2","Esophageal suprabasal cells":"624.3","Extravillous trophoblasts":"499.1","Late spermatids":"1461.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1246.2","Spermatogenic cell types":"1461.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"182.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Skeletal muscle - Skeletal myocytes","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029780","HPA056488"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":52,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA029780":null,"HPA056488":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.58e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044444":null,"HPA062285":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"TEKT2","Gene synonym":["TEKTB1"],"Ensembl":"ENSG00000092850","Gene description":"Tektin 2","Uniprot":["Q9UIF3"],"Chromosome":"1","Position":"36084094-36088275","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"choroid plexus":"27.0","fallopian tube":"59.0","testis":"68.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"567.2","Endometrial ciliated cells":"85.0","Epididymal efferent duct ciliated cells":"90.2","Fallopian tube ciliated cells":"249.8","Late primary spermatocytes":"278.0","Late spermatids":"457.6","Respiratory ciliated cells":"198.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"59","RNA single cell type group specific nCPM":{"Ciliated cells":"249.8","Spermatogenic cell types":"567.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"14","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"9.2","ependymal cell":"32.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"18.8"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"23.9"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"neutrophil":"1.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"granulocytes":"1.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"3.2"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":9,"Subcellular main location":["Connecting piece"],"Subcellular additional location":["Flagellar centriole","Mid piece","Principal piece"],"Antibody RRID":{"HPA027461":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.87e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":28,"Subcellular main location":["Mid piece","Principal piece","End piece"],"Subcellular additional location":["Equatorial segment","Calyx"],"Antibody RRID":{"HPA044354":null,"HPA073565":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"}},{"Gene":"TEKT4","Gene synonym":["MGC27019"],"Ensembl":"ENSG00000163060","Gene description":"Tektin 4","Uniprot":["Q8WW24"],"Chromosome":"2","Position":"94871430-94876823","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"12.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"19","RNA single cell type specific nCPM":{"Early spermatids":"132.0","Endometrial ciliated cells":"49.0","Ependymal cells":"45.4","Epididymal efferent duct ciliated cells":"57.1","Fallopian tube ciliated cells":"71.6","Late primary spermatocytes":"98.5","Late spermatids":"172.3","Respiratory ciliated cells":"87.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Ciliated cells":"87.4","Spermatogenic cell types":"172.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"25","RNA single nuclei brain specific nCPM":{"ependymal cell":"56.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.3"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"midbrain":"3.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":85,"Subcellular main location":["Perinuclear theca","Connecting piece","Flagellar centriole","Principal piece","End piece","Annulus"],"Subcellular additional location":null,"Antibody RRID":{"HPA048600":null,"HPA069872":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"TEKT5","Gene synonym":["CT149","FLJ32871"],"Ensembl":"ENSG00000153060","Gene description":"Tektin 5","Uniprot":["Q96M29"],"Chromosome":"16","Position":"10627501-10694930","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"32","RNA tissue specific nTPM":{"testis":"30.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"772.3","Late spermatids":"237.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"772.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":28,"Subcellular main location":["Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA043578":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TENM4","Gene synonym":["DOC4","KIAA1302","ODZ4","Ten-M4","TEN4"],"Ensembl":"ENSG00000149256","Gene description":"Teneurin transmembrane protein 4","Uniprot":["Q6N022"],"Chromosome":"11","Position":"78652829-79441030","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"14.8","parathyroid gland":"13.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"403.0","Brain excitatory neurons":"354.4","Brain inhibitory neurons":"390.6","Gonadotrophs":"360.2","Lactotrophs":"596.4","Microglia":"428.4","Myosatellite cells":"347.3","Pituitary stem cells":"1692.3","Retinal amacrine cells":"652.4","Retinal ganglion cells":"788.0","Thyrotrophs":"650.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"788.0","Pituitary endocrine cells":"650.5","Stem cells":"1692.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"36.0"},"RNA tissue cell type enrichment":["Colon - 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Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"}},{"Gene":"TENT4B","Gene synonym":["PAPD5","TRF4-2","TUT3"],"Ensembl":"ENSG00000121274","Gene description":"Terminal nucleotidyltransferase 4B","Uniprot":["Q8NDF8"],"Chromosome":"16","Position":"50152911-50235310","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","mRNA processing","rRNA processing"],"Molecular function":["Nucleotidyltransferase","RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"NK-cells":"212.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli","Plasma membrane"],"Antibody RRID":{"HPA042968":null,"HPA048225":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"}},{"Gene":"TENT5C","Gene synonym":["FAM46C","FLJ20202"],"Ensembl":"ENSG00000183508","Gene description":"Terminal nucleotidyltransferase 5C","Uniprot":["Q5VWP2"],"Chromosome":"1","Position":"117606048-117628389","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["Nucleotidyltransferase","RNA-binding","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"84.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"562.7","Erythrocytes":"315.6","Late spermatids":"2755.6","Plasma cells":"737.7","Platelets":"251.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Plasma cells":"737.7","Spermatogenic cell types":"2755.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"57.5","leukocyte":"94.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"14","RNA brain regional specific nTPM":{"choroid plexus":"57.0"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"29.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"17","RNA blood lineage specific nTPM":{"B-cells":"13.4","granulocytes":"29.5","T-cells":"13.7"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"Myeloma":"126.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"2910685.5","Pancreatic islets":"1051331.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"415418.4","pancreas":"621271.2"},"Antibody":["HPA054049"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA054049":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.70e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.84e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"}},{"Gene":"TENT5D","Gene synonym":["CT1.26","CT112","FAM46D","MGC26999"],"Ensembl":"ENSG00000174016","Gene description":"Terminal nucleotidyltransferase 5D","Uniprot":["Q8NEK8"],"Chromosome":"X","Position":"80335504-80445311","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"32","RNA tissue specific nTPM":{"testis":"3.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"10.6","Early primary spermatocytes":"7.9","Early spermatids":"18.3","Late primary spermatocytes":"30.0","Pituitary stem cells":"6.1","Sertoli cells":"7.0","Undifferentiated spermatogonia":"14.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"30.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"2.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059362"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059362":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TERB1","Gene synonym":["CCDC79","FLJ35894"],"Ensembl":"ENSG00000249961","Gene description":"Telomere repeat binding bouquet formation protein 1","Uniprot":["Q8NA31"],"Chromosome":"16","Position":"66754640-66801620","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Meiosis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"11.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early primary spermatocytes":"369.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"26","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"369.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"6.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"1.8"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cell Junctions","Cytosol"],"Antibody RRID":{"HPA079436":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"}},{"Gene":"TERB2","Gene synonym":["C15orf43","MGC33951"],"Ensembl":"ENSG00000167014","Gene description":"Telomere repeat binding bouquet formation protein 2","Uniprot":["Q8NHR7"],"Chromosome":"15","Position":"44956687-44979229","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"testis":"20.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early primary spermatocytes":"118.6","Late primary spermatocytes":"243.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"243.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041780":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"9600","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":25,"Subcellular main location":["Focal adhesion sites","Cytosol"],"Subcellular additional location":["Plasma membrane","Cell Junctions"],"Antibody RRID":{"HPA015269":null,"HPA018123":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.26e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.99e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"}},{"Gene":"TESC","Gene synonym":["CHP3","FLJ20607","TSC"],"Ensembl":"ENSG00000088992","Gene description":"Tescalcin","Uniprot":["Q96BS2"],"Chromosome":"12","Position":"117038923-117099479","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Protein transport","Transport"],"Molecular function":["Protein kinase inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"salivary gland":"310.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"220.4","Conjunctival goblet cells":"232.0","Epididymal principal cells":"267.2","Foveolar cells":"279.2","Late spermatids":"561.8","Megakaryocytes":"228.7","Mucous neck cells":"200.6","Oocytes":"271.7","Pancreatic duct cells":"304.7","Parietal cells":"213.9","Salivary acinar cells":"449.4","Urothelial cells":"390.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Acinar cells":"449.4","Barrier epithelial cells":"390.2","Spermatogenic cell types":"561.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"376.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"262.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"monocytes":"262.4"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"88.8","Gastric cancer":"89.6","Leukemia":"85.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Skin - Eccrine sweat gland cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"5670602.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"98455103.0"},"Antibody":["HPA053200"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":8,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA053200":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.15e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.69e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"}},{"Gene":"TESK2","Gene synonym":[],"Ensembl":"ENSG00000070759","Gene description":"Testis associated actin remodelling kinase 2","Uniprot":["Q96S53"],"Chromosome":"1","Position":"45343883-45491163","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"19.1","Loop of henle epithelial cells":"22.8","Papillary tip epithelial cells":"73.7","Podocytes":"11.6","Proximal tubule cells":"25.8","Renal collecting duct intercalated cells":"13.6","Renal collecting duct principal cells":"27.4","Renal connecting tubule cells":"22.4","Tuft cells":"11.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ductal cells":"27.4","Renal nephron cells":"73.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"2.4","Bergmann glia":"2.1","oligodendrocyte":"2.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"20.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA027257":null,"HPA063869":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.84e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.26e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"}},{"Gene":"TESMIN","Gene synonym":["CXCDC2","MTL5"],"Ensembl":"ENSG00000132749","Gene description":"Testis expressed metallothionein like protein","Uniprot":["Q9Y4I5"],"Chromosome":"11","Position":"68707440-68751520","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"testis":"49.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"131.9","Early spermatids":"106.2","Endometrial luminal cells":"48.1","Late primary spermatocytes":"247.0","Late spermatids":"215.1","Oocytes":"78.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"78.3","Spermatogenic cell types":"247.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"19.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Corticotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"351494.9","Oocytes":"578871.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"26","Protein tissue specific Intensity":{"fallopian tube":"2590.0"},"Antibody":["HPA018539"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA018539":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.91e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.97e-5"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.59e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"TEX2","Gene synonym":["HT008","KIAA1738","TMEM96"],"Ensembl":"ENSG00000136478","Gene description":"Testis expressed 2","Uniprot":["Q8IWB9"],"Chromosome":"17","Position":"64147227-64263260","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"227.0","Neutrophil progenitors":"254.7","pDCs":"194.8","Pituicytes\/FSCs":"184.5","Retinal pigment epithelial cells":"456.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pigment cells":"456.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"plasmacytoid DC":"20.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"20.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Prostate - Smooth muscle cells","Spleen - Endothelial cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"2707558.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"7279504.8"},"Antibody":["HPA020648","HPA057116"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":21,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA020648":null,"HPA057116":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.94e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"}},{"Gene":"TEX22","Gene synonym":[],"Ensembl":"ENSG00000226174","Gene description":"Testis expressed 22","Uniprot":["C9J3V5"],"Chromosome":"14","Position":"105398538-105450106","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"5.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"18","RNA single cell type specific nCPM":{"Early spermatids":"305.2","Late primary spermatocytes":"245.2","Late spermatids":"970.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"34","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"970.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA065576"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA065576":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TEX26","Gene synonym":["C13orf26","MGC40178"],"Ensembl":"ENSG00000175664","Gene description":"Testis expressed 26","Uniprot":["Q8N6G2"],"Chromosome":"13","Position":"30932656-30975500","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"choroid plexus":"11.2","testis":"20.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"1081.0","Late spermatids":"2861.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"31","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2861.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"55.3","ependymal cell":"104.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"188521.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA079709"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA079709":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.13e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TEX261","Gene synonym":["MGC32043","TEG-261"],"Ensembl":"ENSG00000144043","Gene description":"Testis expressed 261","Uniprot":["Q6UWH6"],"Chromosome":"2","Position":"70968325-70994873","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Tuft cells":"11.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Secretory gland support":"11.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 95: Tuft cells - Chemosensory signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA016631":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":48,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB005002":null,"HPA017739":null,"HPA073223":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":26,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Plasma membrane","Cytosol"],"Antibody RRID":{"HPA062468":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":14,"Subcellular main location":["Primary cilium","Centrosome","Cytosol"],"Subcellular additional location":["Nucleoplasm","Nucleoli fibrillar center","Vesicles","Basal body"],"Antibody RRID":{"HPA039415":null,"HPA042036":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"TFAM","Gene synonym":["TCF6","TCF6L2"],"Ensembl":"ENSG00000108064","Gene description":"Transcription factor A, mitochondrial","Uniprot":["Q00059"],"Chromosome":"10","Position":"58385345-58399220","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"785.5","Late spermatids":"1338.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1338.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040648","HPA063684"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":50,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA040648":null,"HPA063684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.17e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.12e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.90e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"}},{"Gene":"TFAP2B","Gene synonym":["AP-2beta","AP2-B"],"Ensembl":"ENSG00000008196","Gene description":"Transcription factor AP-2 beta","Uniprot":["Q92481"],"Chromosome":"6","Position":"50818723-50847619","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"31.4","retina":"13.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"117.0","Breast hormone-responsive cells":"96.5","Distal convoluted tubule cells":"78.7","Epididymal principal cells":"147.4","Lacrimal acinar cells":"63.4","Loop of henle epithelial cells":"107.6","Melanocytes":"231.0","Retinal amacrine cells":"594.4","Retinal horizontal cells":"376.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"594.4","Pigment cells":"231.0","Reproductive supporting cells":"147.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"21","RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"230.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"22.7"},"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"6","RNA brain regional specific nTPM":{"cerebellum":"7.2","medulla oblongata":"8.2","midbrain":"19.8","pons":"21.4"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"10","RNA cell line specific nTPM":{"Bone cancer":"22.5","breast cancer":"22.4","Neuroblastoma":"51.4"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Breast - Breast glandular cells","Breast - Breast glandular cells","Kidney - Ascending Loop of Henle cells","Pituitary gland - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebellum":"10.0"},"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"cerebellum":"13.8"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA034683","HPA062942"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034683":null,"HPA062942":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"}},{"Gene":"TFB1M","Gene synonym":["CGI-75","mtTFB"],"Ensembl":"ENSG00000029639","Gene description":"Transcription factor B1, mitochondrial","Uniprot":["Q8WVM0"],"Chromosome":"6","Position":"155256134-155314493","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["rRNA processing","Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Methyltransferase","RNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"235.5","Late primary spermatocytes":"206.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"235.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"4477416.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"486491.8","lymphoid tissue":"525979.1"},"Antibody":["HPA029428"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA029428":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.56e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"}},{"Gene":"TFDP2","Gene synonym":["Dp-2"],"Ensembl":"ENSG00000114126","Gene description":"Transcription factor Dp-2","Uniprot":["Q14188"],"Chromosome":"3","Position":"141944428-142149544","Protein class":["Cancer-related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Cell cycle","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"157.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1042.2","Late primary spermatocytes":"801.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1042.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"691","Protein cell type specific Intensity":{"Collecting ducts":"41830.3","Distal tubules":"122594.9","Granulosa cells":"42966.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"51","Protein tissue specific Intensity":{"kidney":"5107.8"},"Antibody":["CAB018396","HPA070399"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Mitotic spindle"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Mitotic spindle"],"Antibody RRID":{"CAB018396":null,"HPA070399":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.07e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.44e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.85e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"}},{"Gene":"TFIP11","Gene synonym":["DKFZP434B194","Spp382","TIP39"],"Ensembl":"ENSG00000100109","Gene description":"Tuftelin interacting protein 11","Uniprot":["Q9UBB9"],"Chromosome":"22","Position":"26491225-26512505","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Biomineralization","mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"107.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"107.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Prostate basal glandular cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"4991221.1","lymphoid tissue":"7297920.2"},"Antibody":["HPA027085"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":262,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA027085":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.36e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.41e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"}},{"Gene":"TGFA","Gene synonym":[],"Ensembl":"ENSG00000163235","Gene description":"Transforming growth factor alpha","Uniprot":["P01135"],"Chromosome":"2","Position":"70447284-70554193","Protein class":["Cancer-related genes","Human disease related genes","Plasma proteins","Predicted membrane proteins","Predicted secreted proteins","RAS pathway related proteins"],"Biological process":null,"Molecular function":["Growth factor","Mitogen"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"24.5","esophagus":"24.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"145.7","Endometrial glandular cells":"116.4","Esophageal apical cells":"305.9","Neutrophils":"146.0","Pancreatic duct cells":"150.7","Urothelial cells":"180.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"305.9","Barrier epithelial cells":"180.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"56.1","oligodendrocyte precursor cell":"137.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"62.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"11.4","eosinophil":"23.9","neutrophil":"24.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"24.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"179.0"},"RNA tissue cell type enrichment":["Spleen - Macrophages","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042297"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":"Secreted to blood","Secretome function":"Growth factor","CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":57900,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA042297":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.79e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.64e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"}},{"Gene":"TGIF2LX","Gene synonym":[],"Ensembl":"ENSG00000153779","Gene description":"TGFB induced factor homeobox 2 like X-linked","Uniprot":["Q8IUE1"],"Chromosome":"X","Position":"89921908-89922883","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"86","RNA tissue specific nTPM":{"testis":"8.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"51","RNA single cell type specific nCPM":{"Early spermatids":"61.5","Late primary spermatocytes":"49.4","Late spermatids":"62.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"56","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"62.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"3.1","Neuroblastoma":"3.6"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":22,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TGIF2LY","Gene synonym":[],"Ensembl":"ENSG00000176679","Gene description":"TGFB induced factor homeobox 2 like Y-linked","Uniprot":["Q8IUE0"],"Chromosome":"Y","Position":"3579067-3580041","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"38","RNA tissue specific nTPM":{"testis":"3.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"44","RNA single cell type specific nCPM":{"Early spermatids":"9.3","Late primary spermatocytes":"20.6","Late spermatids":"20.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"209","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"20.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TGM3","Gene synonym":["TGE"],"Ensembl":"ENSG00000125780","Gene description":"Transglutaminase 3","Uniprot":["Q08188"],"Chromosome":"20","Position":"2296001-2341079","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Keratinization"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"esophagus":"1777.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"18","RNA single cell type specific nCPM":{"Esophageal apical cells":"848.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"848.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"20.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"11","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"106.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"295","RNA blood cell specific nTPM":{"neutrophil":"30.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"304","RNA blood lineage specific nTPM":{"granulocytes":"30.4"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"19","RNA cell line specific nTPM":{"Rhabdoid":"124.8"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"105944011.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"737261565.2"},"Antibody":["HPA004728"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":32,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA004728":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB033571":null,"HPA073290":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TGM7","Gene synonym":["TGMZ"],"Ensembl":"ENSG00000159495","Gene description":"Transglutaminase 7","Uniprot":["Q96PF1"],"Chromosome":"15","Position":"43276271-43302255","Protein class":["Cancer-related genes","Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"1.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"88.8","Esophageal apical cells":"42.9","Late primary spermatocytes":"12.0","Late spermatids":"23.5","Oocytes":"13.8","Suprabasal keratinocytes":"7.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"42.9","Spermatogenic cell types":"88.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"12","RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"2.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":15,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":21,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus","Cytosol"],"Antibody RRID":{"HPA041416":null,"HPA073220":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"}},{"Gene":"THAP2","Gene synonym":["DKFZP564I0422"],"Ensembl":"ENSG00000173451","Gene description":"THAP domain containing 2","Uniprot":["Q9H0W7"],"Chromosome":"12","Position":"71664301-71680644","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"93.6","Late spermatids":"83.5","Mast cells":"50.3","monocytes":"108.0","Vascular smooth muscle cells":"53.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"108.0","Spermatogenic cell types":"93.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA039790":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"}},{"Gene":"THAP5","Gene synonym":["DKFZp313O1132"],"Ensembl":"ENSG00000177683","Gene description":"THAP domain containing 5","Uniprot":["Q7Z6K1"],"Chromosome":"7","Position":"108554543-108569750","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Cell cycle","Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"61.8","Late spermatids":"114.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"114.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043170":null,"HPA051488":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.44e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"}},{"Gene":"THAP6","Gene synonym":["MGC30052"],"Ensembl":"ENSG00000174796","Gene description":"THAP domain containing 6","Uniprot":["Q8TBB0"],"Chromosome":"4","Position":"75513946-75550473","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"126.7","Early spermatids":"175.1","Late primary spermatocytes":"105.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"175.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":15,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035767":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-5"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.92e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"}},{"Gene":"THAP9","Gene synonym":["FLJ34093"],"Ensembl":"ENSG00000168152","Gene description":"THAP domain containing 9","Uniprot":["Q9H5L6"],"Chromosome":"4","Position":"82900684-82919969","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["DNA integration","DNA recombination"],"Molecular function":["DNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"65.5","Late spermatids":"81.2","Neutrophils":"69.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"69.3","Spermatogenic cell types":"81.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA037420":null,"HPA037421":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.53e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.43e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"THEGL","Gene synonym":[],"Ensembl":"ENSG00000249693","Gene description":"Theg spermatid protein like","Uniprot":["P0DJG4"],"Chromosome":"4","Position":"56530606-56603507","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"3.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"10.6","Choroid plexus epithelial cells":"7.2","Early spermatids":"54.9","Epididymal efferent duct ciliated cells":"10.1","Late primary spermatocytes":"36.4","Late spermatids":"33.0","Retinal pigment epithelial cells":"8.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"54.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"6.9"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA068093"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA068093":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"THG1L","Gene synonym":["FLJ11601","FLJ20546","hTHG1","ICF45","IHG-1"],"Ensembl":"ENSG00000113272","Gene description":"TRNA-histidine guanylyltransferase 1 like","Uniprot":["Q9NWX6"],"Chromosome":"5","Position":"157731420-157741449","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"54.2","Early spermatids":"80.8","Late primary spermatocytes":"91.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"91.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1001690.2"},"Antibody":["HPA035877","HPA035878"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035877":null,"HPA035878":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.38e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.79e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"}},{"Gene":"THOC1","Gene synonym":["HPR1","P84"],"Ensembl":"ENSG00000079134","Gene description":"THO complex subunit 1","Uniprot":["Q96FV9"],"Chromosome":"18","Position":"214520-268050","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Apoptosis","mRNA processing","mRNA splicing","mRNA transport","Transcription","Transcription regulation","Transport"],"Molecular function":["DNA-binding","RNA-binding"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"3437652.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019096","HPA019687"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":75,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA019096":null,"HPA019687":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.50e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.81e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"3685220.0","lymphoid tissue":"3953935.6"},"Antibody":["HPA048402"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA048402":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.37e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.51e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"}},{"Gene":"THOC7","Gene synonym":["FLJ23445","fSAP24","NIF3L1BP1"],"Ensembl":"ENSG00000163634","Gene description":"THO complex subunit 7","Uniprot":["Q6I9Y2"],"Chromosome":"3","Position":"63833870-63863868","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing","mRNA transport","Transport"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"311.2","Esophageal suprabasal cells":"350.2","Megakaryocytes":"327.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":48,"Subcellular main location":["Nuclear speckles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA044143":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.36e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.21e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.84e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"}},{"Gene":"THOP1","Gene synonym":[],"Ensembl":"ENSG00000172009","Gene description":"Thimet oligopeptidase 1","Uniprot":["P52888"],"Chromosome":"19","Position":"2785503-2815807","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"127.3","Enterocytes":"281.0","Hepatocytes":"99.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"281.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB025497","HPA035262"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1700000","Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB025497":null,"HPA035262":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.76e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.11e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"}},{"Gene":"THPO","Gene synonym":["MGDF","MPLLG","TPO"],"Ensembl":"ENSG00000090534","Gene description":"Thrombopoietin","Uniprot":["P40225"],"Chromosome":"3","Position":"184371935-184381968","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Cytokine","Hormone"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"liver":"33.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"3.7","Brain excitatory neurons":"2.4","Decidual stromal cells":"2.7","Early spermatids":"2.2","Endometrial stromal cells":"2.5","Epicardial cells":"2.3","Fibroblasts":"3.2","Hepatocytes":"15.1","Kupffer cells":"3.1","Late primary spermatocytes":"2.7","Late spermatids":"8.5","Myosatellite cells":"3.6","Pericytes":"4.5","Vascular smooth muscle cells":"2.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Hepatocytes":"15.1","Mural cells":"4.5","Spermatogenic cell types":"8.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper-layer intratelencephalic":"5.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"12.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"4.1","lymphoma":"3.1"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":1070000,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-2"}},{"Gene":"THSD8","Gene synonym":[],"Ensembl":"ENSG00000284491","Gene description":"Thrombospondin type 1 domain containing 8","Uniprot":["A0A1W2PP97"],"Chromosome":"19","Position":"12802031-12813581","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Breast myoepithelial cells":"93.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Secretory gland support":"93.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"THTPA","Gene synonym":["THTPASE"],"Ensembl":"ENSG00000259431","Gene description":"Thiamine triphosphatase","Uniprot":["Q9BU02"],"Chromosome":"14","Position":"23555988-23560271","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"8.3","Bergmann glia":"10.0","Brain excitatory neurons":"8.5","Brain inhibitory neurons":"8.3","Choroid plexus epithelial cells":"4.6","Ependymal cells":"5.0","Loop of henle epithelial cells":"3.0","Microglia":"6.4","Oligodendrocyte progenitor cells":"6.4","Oligodendrocytes":"10.1","Other brain neurons":"10.9","Podocytes":"3.9","Proximal tubule cells":"3.0","Renal collecting duct principal cells":"3.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"5.0","Glial cells":"10.1","Neuronal cells":"10.9","Renal nephron cells":"3.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA028876":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-3"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"}},{"Gene":"THUMPD3","Gene synonym":["DKFZP434F091"],"Ensembl":"ENSG00000134077","Gene description":"THUMP domain containing 3","Uniprot":["Q9BV44"],"Chromosome":"3","Position":"9362971-9386791","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Methyltransferase","RNA-binding","Transferase","tRNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"261.3","Late primary spermatocytes":"391.8","Late spermatids":"177.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"391.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":11,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA036170":null,"HPA036171":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.08e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"}},{"Gene":"TIFAB","Gene synonym":[],"Ensembl":"ENSG00000255833","Gene description":"TIFA inhibitor","Uniprot":["Q6ZNK6"],"Chromosome":"5","Position":"135444226-135452351","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"5.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"cDC":"26.8","Late spermatids":"16.0","pDCs":"30.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"dendritic cells":"30.2","Spermatogenic cell types":"16.0"},"RNA single nuclei brain specificity":null,"RNA single nuclei brain distribution":null,"RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"myeloid DC":"4.5","plasmacytoid DC":"13.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"dendritic cells":"13.9"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"38","RNA cell line specific nTPM":{"Leukemia":"3.8"},"RNA tissue cell type enrichment":["Lung - T-cells","Spleen - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"5319","Protein cell type specific Intensity":{"B-cells":"452507.4","Macrophages":"729811.7","T-cells":"413255.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"15890","Protein tissue specific Intensity":{"lymphoid tissue":"1589021.9"},"Antibody":["HPA049372"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049372":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TIGD4","Gene synonym":[],"Ensembl":"ENSG00000169989","Gene description":"Tigger transposable element derived 4","Uniprot":["Q8IY51"],"Chromosome":"4","Position":"152769354-152779730","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"retina":"20.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"107.3","Ependymal cells":"53.4","Late primary spermatocytes":"115.5","Microglia":"43.7","Pituitary stem cells":"38.2","Respiratory ciliated cells":"34.2","Rod photoreceptor cells":"65.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"53.4","Glial cells":"43.7","Neuronal cells":"65.7","Spermatogenic cell types":"115.5","Stem cells":"38.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"49.7","ependymal cell":"58.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 20: Myeloma - Immune response","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":2,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA035649":null,"HPA073768":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TIMM23","Gene synonym":["TIM23"],"Ensembl":"ENSG00000265354","Gene description":"Translocase of inner mitochondrial membrane 23","Uniprot":["O14925"],"Chromosome":"10","Position":"45972489-46003742","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":["Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"236.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"236.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":22,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA031408":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.68e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":25,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA048843":null,"HPA056448":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"19000","Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA002932":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.38e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.29e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"}},{"Gene":"TIPARP","Gene synonym":["ARTD14","DDF1","DKFZP434J214","DKFZp686N0351","PARP-1","PARP-7","PARP7","pART14","RM1"],"Ensembl":"ENSG00000163659","Gene description":"TCDD inducible poly(ADP-ribose) polymerase","Uniprot":["Q7Z3E1"],"Chromosome":"3","Position":"156673235-156706770","Protein class":["Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial secretory cells":"424.9","Urothelial cells":"532.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"101.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"53.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"53.6"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary gland basal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036796"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 69: Parathyroid gland - Mixed function","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":3,"Subcellular main location":["Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA036796":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.63e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.84e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"}},{"Gene":"TIPIN","Gene synonym":["FLJ20516"],"Ensembl":"ENSG00000075131","Gene description":"TIMELESS interacting protein","Uniprot":["Q9BVW5"],"Chromosome":"15","Position":"66336191-66386746","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","DNA damage","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"78.0","Early primary spermatocytes":"153.9","Late primary spermatocytes":"96.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"153.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"925","Protein cell type specific Intensity":{"Granulosa cells":"146359.1","Oocytes":"38679.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039704","HPA058799"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":14,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039704":null,"HPA058799":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.76e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.58e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"}},{"Gene":"TJP3","Gene synonym":["ZO-3"],"Ensembl":"ENSG00000105289","Gene description":"Tight junction protein 3","Uniprot":["O95049"],"Chromosome":"19","Position":"3708362-3750813","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"24.6","intestine":"40.5","stomach 1":"25.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"146.5","Colonocytes":"257.4","Early spermatids":"404.4","Enterocytes":"197.9","Esophageal apical cells":"313.3","Foveolar cells":"173.4","Late primary spermatocytes":"321.5","Respiratory ciliated cells":"190.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"313.3","Enterocytes":"257.4","Spermatogenic cell types":"404.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"24.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"9","RNA brain regional specific nTPM":{"choroid plexus":"16.2"},"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"gdT-cell":"1.2","MAIT T-cell":"3.9","memory CD4 T-cell":"3.1","memory CD8 T-cell":"2.4","naive CD4 T-cell":"3.3","naive CD8 T-cell":"1.2","T-reg":"3.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"T-cells":"3.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Colon - Colon enterocytes","Lung - Alveolar cells type 2","Prostate - Urothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"13354789.5","Collecting ducts":"17797065.5","Distal tubules":"5426763.7","Fallopian tube cells":"15121654.7","Large ducts":"8057975.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"6656157.4"},"Antibody":["CAB013244","HPA046863","HPA053337"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Plasma membrane","Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":1,"Subcellular main location":["Nucleoplasm","Cell Junctions"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB013244":null,"HPA046863":null,"HPA053337":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - 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Breast glandular cells","Breast - Breast glandular cells","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"284478736.8","Hepatocytes":"805049283.8","Proximal tubules":"715784232.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"1006129258.4"},"Antibody":["HPA039486","HPA048186"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"7600000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":22,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039486":null,"HPA048186":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.11e-8"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"}},{"Gene":"TKTL2","Gene synonym":["DKFZP434L1717","FLJ32975"],"Ensembl":"ENSG00000151005","Gene description":"Transketolase like 2","Uniprot":["Q9H0I9"],"Chromosome":"4","Position":"163471095-163473754","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"372","RNA tissue specific nTPM":{"testis":"54.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Late primary spermatocytes":"400.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"210","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"400.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TLCD1","Gene synonym":[],"Ensembl":"ENSG00000160606","Gene description":"TLC domain containing 1","Uniprot":["Q96CP7"],"Chromosome":"17","Position":"28724348-28727935","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"55.3","Endometrial glandular cells":"43.2","Enterocytes":"48.2","Epididymal basal cells":"64.8","Urothelial cells":"76.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"76.9","Basal cells":"64.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"astrocyte":"7.4","Bergmann glia":"14.9","ependymal cell":"6.1","oligodendrocyte precursor cell":"3.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"11","RNA blood cell specific nTPM":{"plasmacytoid DC":"21.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"11","RNA blood lineage specific nTPM":{"dendritic cells":"21.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042366":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.29e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.43e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"TLCD3B","Gene synonym":["DKFZP434I2117","FAM57B"],"Ensembl":"ENSG00000149926","Gene description":"TLC domain containing 3B","Uniprot":["Q71RH2"],"Chromosome":"16","Position":"30024427-30052978","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Lipid biosynthesis","Lipid metabolism"],"Molecular function":["Transferase"],"Disease involvement":["Cone-rod dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"83.9","retina":"63.1","testis":"99.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"97.3","Early primary spermatocytes":"37.0","Early spermatids":"123.6","Late primary spermatocytes":"190.6","Late spermatids":"83.7","Retinal bipolar cells":"25.0","Rod photoreceptor cells":"127.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Neuronal cells":"127.4","Spermatogenic cell types":"190.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"12.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Neuroblastoma":"47.9"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Colon - Colon enteroendocrine cells","Pancreas - Alpha cells","Pituitary gland - Lactotropes","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"440","Protein cell type specific Intensity":{"Microglia and Neuropil":"35300.9","Neurons":"52644.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.32e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TLE4","Gene synonym":["E(spl)","ESG","GRG4"],"Ensembl":"ENSG00000106829","Gene description":"TLE family member 4, transcriptional corepressor","Uniprot":["Q04727"],"Chromosome":"9","Position":"79571773-79726882","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Wnt signaling pathway"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"94.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1051.1","Endometrial ciliated cells":"870.6","Lactotrophs":"1586.6","Late spermatids":"2003.5","Neutrophil progenitors":"901.6","Neutrophils":"1303.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Pituitary endocrine cells":"1586.6","Spermatogenic cell types":"2003.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"902.4","deep-layer near-projecting":"904.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"22.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast myoepithelial cells","Pituitary gland - Lactotropes","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Microglia and Neuropil":"1456137.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"255","Protein tissue specific Intensity":{"lymphoid tissue":"25528.4"},"Antibody":["HPA065357"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA065357":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}},{"Gene":"TLK2","Gene synonym":["MGC44450","PKU-ALPHA"],"Ensembl":"ENSG00000146872","Gene description":"Tousled like kinase 2","Uniprot":["Q86UE8"],"Chromosome":"17","Position":"62458658-62615481","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","DNA damage"],"Molecular function":["Chromatin regulator","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"333.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":42,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA056342":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.81e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.47e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.30e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"}},{"Gene":"TLR3","Gene synonym":["CD283"],"Ensembl":"ENSG00000164342","Gene description":"Toll like receptor 3","Uniprot":["O15455"],"Chromosome":"4","Position":"186068911-186088073","Protein class":["CD markers","Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Immunity","Inflammatory response","Innate immunity"],"Molecular function":["Receptor","RNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"28.2","Early spermatids":"101.7","Endometrial glandular cells":"26.1","Foveolar cells":"30.3","Microglia":"28.6","Syncytiotrophoblasts":"28.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"101.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"37.6","fibroblast":"9.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"44.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"2.9","memory CD8 T-cell":"3.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Kidney cancer":"12.1"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025658":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.98e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.16e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"}},{"Gene":"TM4SF20","Gene synonym":["FLJ22800","TCCE518"],"Ensembl":"ENSG00000168955","Gene description":"Transmembrane 4 L six family member 20","Uniprot":["Q53R12"],"Chromosome":"2","Position":"227362038-227381995","Protein class":["Disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Autism spectrum disorder"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"76","RNA tissue specific nTPM":{"intestine":"251.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Enterocytes":"796.4","Gastric progenitor cells":"271.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Enterocytes":"796.4","Proliferating cells":"271.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"7.6","Liver Hepatocellular Carcinoma (TCGA)":"7.3","Pancreatic Adenocarcinoma (TCGA)":"9.1","Rectum Adenocarcinoma (TCGA)":"8.8","Stomach Adenocarcinoma (TCGA)":"18.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"3.0","Gastric cancer":"2.0"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":6,"Subcellular main location":["Plasma membrane","Focal adhesion sites"],"Subcellular additional location":null,"Antibody RRID":{"HPA051838":null,"HPA063184":null,"HPA065531":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TM6SF1","Gene synonym":[],"Ensembl":"ENSG00000136404","Gene description":"Transmembrane 6 superfamily member 1","Uniprot":["Q9BZW5"],"Chromosome":"15","Position":"83107572-83144854","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"44.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"59.9","Epicardial cells":"54.6","Hofbauer cells":"63.6","Kupffer cells":"62.5","Macrophages":"89.7","Megakaryocytes":"105.1","Microglia":"216.0","Myonuclei":"88.5","Neutrophil progenitors":"85.3","Neutrophils":"114.9","Platelets":"77.6","Vascular endothelial cells":"59.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"216.0","Megakaryocytes":"105.1","Mononuclear phagocytes":"89.7","Myocytes":"88.5","Neutrophils":"114.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"277.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"77.1","eosinophil":"196.3","neutrophil":"118.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"196.3"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Leukemia":"10.5","lymphoma":"9.0","Myeloma":"3.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016051":null,"HPA056857":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"}},{"Gene":"TMA16","Gene synonym":["C4orf43","FLJ11184"],"Ensembl":"ENSG00000198498","Gene description":"Translation machinery associated 16 homolog","Uniprot":["Q96EY4"],"Chromosome":"4","Position":"163494442-163520539","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"160.5","Late primary spermatocytes":"227.5","Late spermatids":"252.1","Megakaryocytes":"160.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"252.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"12000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":16,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA041571":null,"HPA052688":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.46e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.07e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.18e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.74e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"}},{"Gene":"TMBIM4","Gene synonym":["CGI-119","GAAP","LFG4","S1R","ZPRO"],"Ensembl":"ENSG00000155957","Gene description":"Transmembrane BAX inhibitor motif containing 4","Uniprot":["Q9HC24"],"Chromosome":"12","Position":"66135846-66170027","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Apoptosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"279.5","Gastric chief cells":"364.7","Late primary spermatocytes":"806.4","Parietal cells":"392.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"392.5","Spermatogenic cell types":"806.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"89","Protein cell type specific Intensity":{"Collecting ducts":"6003.0","Fallopian tube cells":"11794.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA077642"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA077642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"}},{"Gene":"TMC1","Gene synonym":["DFNA36","DFNB11","DFNB7"],"Ensembl":"ENSG00000165091","Gene description":"Transmembrane channel like 1","Uniprot":["Q8TDI8"],"Chromosome":"9","Position":"72521608-72838297","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":["Hearing","Ion transport","Transport"],"Molecular function":["Ion channel"],"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"1.1","cervix":"1.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"145.0","Esophageal apical cells":"316.0","Extravillous trophoblasts":"94.6","Migrating cytotrophoblasts":"100.8","Podocytes":"95.8","Prostatic club cells":"99.6","Prostatic hillock cells":"82.4","Proximal tubule cells":"245.7","Syncytiotrophoblasts":"81.9","Urothelial cells":"318.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"316.0","Barrier epithelial cells":"318.1","Renal nephron cells":"245.7","Trophoblast cells":"145.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"48.1","Bergmann glia":"61.2","endothelial cell":"33.4","ependymal cell":"34.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 18: Non-specific - Mixed function","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":5,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA056530":null,"HPA064017":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMDD1","Gene synonym":["C12orf81","hCG1648055"],"Ensembl":"ENSG00000284730","Gene description":"Transmembrane and death domain 1","Uniprot":["P0DPE3"],"Chromosome":"12","Position":"51813921-51814925","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"liver":"1.4","testis":"3.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast lactating cells":"6.8","Early spermatids":"32.8","Epididymal principal cells":"13.3","Hepatocytes":"4.5","Late primary spermatocytes":"19.1","Late spermatids":"13.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"13.3","Spermatogenic cell types":"32.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"2.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEFF1","Gene synonym":["C9orf2","CT120.1","H7365"],"Ensembl":"ENSG00000241697","Gene description":"Transmembrane protein with EGF like and two follistatin like domains 1","Uniprot":["Q8IYR6"],"Chromosome":"9","Position":"100473149-100577636","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"brain":"12.9","testis":"3.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"26.8","Brain excitatory neurons":"71.0","Brain inhibitory neurons":"105.6","Ependymal cells":"25.0","Oligodendrocyte progenitor cells":"51.7","Oligodendrocytes":"308.7","Other brain neurons":"89.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Glial cells":"308.7","Neuronal cells":"105.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"441.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.0","Ovary Serous Cystadenocarcinoma (TCGA)":"4.6","Testicular Germ Cell Tumor (TCGA)":"2.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"28.7"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA051501":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.27e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM106A","Gene synonym":["MGC20235"],"Ensembl":"ENSG00000184988","Gene description":"Transmembrane protein 106A","Uniprot":["Q96A25"],"Chromosome":"17","Position":"43211835-43220041","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":["Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"20.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"46.8","Hofbauer cells":"107.9","Kupffer cells":"61.5","Macrophages":"65.5","Microglia":"69.4","monocytes":"51.8","Proximal tubule cells":"94.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"69.4","Mononuclear phagocytes":"107.9","Renal nephron cells":"94.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"87.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"26.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"26.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":117,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.57e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"}},{"Gene":"TMEM108","Gene synonym":["CT124","MGC3040"],"Ensembl":"ENSG00000144868","Gene description":"Transmembrane protein 108","Uniprot":["Q6UXF1"],"Chromosome":"3","Position":"133038391-133397775","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"32.3","skeletal muscle":"21.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"549.5","Astrocytes":"364.5","Bergmann glia":"1263.6","Brain excitatory neurons":"414.7","Cone photoreceptor cells":"2026.6","Ependymal cells":"397.7","Myonuclei":"490.8","Oligodendrocyte progenitor cells":"636.6","Oligodendrocytes":"774.7","Rod photoreceptor cells":"2247.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"549.5","Glial cells":"1263.6","Neuronal cells":"2247.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"4143.0"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"21.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Neuroblastoma":"56.7"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"23000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":3,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoli","Vesicles"],"Antibody RRID":{"HPA063350":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.23e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - 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Adrenal cortex cells","Heart muscle - Cardiomyocytes","Minor Salivary Gland - Minor salivary gland ductal cells","Stomach - Parietal cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040720"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA040720":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"}},{"Gene":"TMEM117","Gene synonym":["DKFZp434K2435"],"Ensembl":"ENSG00000139173","Gene description":"Transmembrane protein 117","Uniprot":["Q9H0C3"],"Chromosome":"12","Position":"43835967-44389762","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1747.6","Corticotrophs":"1118.8","Gonadotrophs":"1027.9","Renal collecting duct intercalated cells":"1893.7","Thyrotrophs":"711.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1747.6","Ductal cells":"1893.7","Pituitary endocrine cells":"1118.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1449.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046223":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"}},{"Gene":"TMEM120A","Gene synonym":["NET29","TACAN","TMPIT"],"Ensembl":"ENSG00000189077","Gene description":"Transmembrane protein 120A","Uniprot":["Q9BXJ8"],"Chromosome":"7","Position":"75986831-75994656","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"1752.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1752.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"223.9"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"3138","Protein cell type specific Intensity":{"Hepatocytes":"294788.6","Proximal tubules":"332859.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"152493.1","liver":"563991.2"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":28,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"}},{"Gene":"TMEM125","Gene synonym":["MGC17299"],"Ensembl":"ENSG00000179178","Gene description":"Transmembrane protein 125","Uniprot":["Q96AQ2"],"Chromosome":"1","Position":"43269983-43274002","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"64.4","lung":"71.4","pancreas":"85.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"155.2","Alveolar cells type 2":"196.8","Breast lactating cells":"94.1","Enterocytes":"147.1","Esophageal apical cells":"81.8","Oligodendrocytes":"86.3","Respiratory ciliated cells":"77.4","Transitional alveolar cells":"123.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"196.8","Enterocytes":"147.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"111.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Colon - Colon enterocytes","Liver - Cholangiocytes","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Pituitary gland - Somatotropes","Prostate - Prostate glandular cells","Skin - Keratinocyte (granular)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015796"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Midbody","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":null,"Subcellular main location":["Midbody","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA015796":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.30e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.72e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.24e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.27e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"}},{"Gene":"TMEM126A","Gene synonym":["DKFZp586C1924","OPA7"],"Ensembl":"ENSG00000171202","Gene description":"Transmembrane protein 126A","Uniprot":["Q9H061"],"Chromosome":"11","Position":"85647967-85656547","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"211.5","Late primary spermatocytes":"296.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"296.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"10646798.8"},"Antibody":["HPA046648"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":27,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA046648":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.05e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.84e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.23e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"}},{"Gene":"TMEM132D","Gene synonym":["KIAA1944","MOLT","PPP1R153"],"Ensembl":"ENSG00000151952","Gene description":"Transmembrane protein 132D","Uniprot":["Q14C87"],"Chromosome":"12","Position":"129071725-129904025","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"brain":"6.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"268.2","Brain inhibitory neurons":"359.3","Gonadotrophs":"231.8","Lactotrophs":"189.3","Neuroendocrine cells":"155.7","Oligodendrocyte progenitor cells":"834.5","Other brain neurons":"335.2","Pancreatic islet cells":"753.7","Pituitary stem cells":"246.2","Prostatic glandular cells":"164.5","Retinal bipolar cells":"127.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"834.5","Neuronal cells":"359.3","Pancreatic islet cells":"753.7","Stem cells":"246.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"1349.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"thyroid cancer":"1.8"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"57000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA010739":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM132E","Gene synonym":["DFNB99"],"Ensembl":"ENSG00000181291","Gene description":"Transmembrane protein 132E","Uniprot":["Q6IEE7"],"Chromosome":"17","Position":"34579487-34639318","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"12.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"8.1","Brain excitatory neurons":"8.7","Brain inhibitory neurons":"9.4","cDC":"4.6","Differentiating spermatogonia":"5.4","Early primary spermatocytes":"7.1","Hepatic stellate cells":"6.5","Kupffer cells":"11.3","Late spermatids":"10.7","Oligodendrocyte progenitor cells":"17.6","Other brain neurons":"16.5","Proximal tubule cells":"11.9","Retinal amacrine cells":"21.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"17.6","Mononuclear phagocytes":"11.3","Neuronal cells":"21.5","Renal nephron cells":"11.9","Spermatogenic cell types":"10.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"9.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"3.9"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"HPA070608":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM139","Gene synonym":["FLJ90586"],"Ensembl":"ENSG00000178826","Gene description":"Transmembrane protein 139","Uniprot":["Q8IV31"],"Chromosome":"7","Position":"143279957-143288048","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"31.8","kidney":"30.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"40.9","Breast myoepithelial cells":"30.1","Cholangiocytes":"24.3","Colonocytes":"40.9","Cytotrophoblasts":"37.2","Endometrial luminal cells":"27.7","Endometrial secretory cells":"43.1","Enterocytes":"81.4","Late spermatids":"23.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Alveolar cells":"40.9","Enterocytes":"81.4","Secretory cells":"43.1","Trophoblast cells":"37.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"6.3","oligodendrocyte":"7.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Papillary Cell Carcinoma (TCGA)":"43.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Minor salivary glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"351","Protein tissue specific Intensity":{"kidney":"35055.4"},"Antibody":["HPA036982","HPA036983"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Focal adhesion sites"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":35,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Focal adhesion sites"],"Antibody RRID":{"HPA036982":null,"HPA036983":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.23e-8"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"}},{"Gene":"TMEM144","Gene synonym":["FLJ11155"],"Ensembl":"ENSG00000164124","Gene description":"Transmembrane protein 144","Uniprot":["Q7Z5S9"],"Chromosome":"4","Position":"158201604-158255416","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"brain":"218.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Oligodendrocytes":"1569.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"1569.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2149.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"2.1","plasmacytoid DC":"2.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"dendritic cells":"2.2","monocytes":"1.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA063554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"}},{"Gene":"TMEM183A","Gene synonym":["C1orf37"],"Ensembl":"ENSG00000163444","Gene description":"Transmembrane protein 183A","Uniprot":["Q8IXX5"],"Chromosome":"1","Position":"203007374-203024848","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"117.1","Late spermatids":"97.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"117.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 54: Intestinal epithelial cells - Intestinal epi homeostasis & respiration","Interactions":11,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Cell Junctions"],"Antibody RRID":{"HPA072607":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"TMEM200C","Gene synonym":["TTMA"],"Ensembl":"ENSG00000206432","Gene description":"Transmembrane protein 200C","Uniprot":["A6NKL6"],"Chromosome":"18","Position":"5882072-5895955","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"3.7","brain":"3.2","salivary gland":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"9.8","Adrenal medulla cells":"10.6","Bergmann glia":"14.6","Brain inhibitory neurons":"14.2","Lacrimal acinar cells":"8.2","Oligodendrocyte progenitor cells":"26.1","Other brain neurons":"7.7","Podocytes":"36.1","Retinal amacrine cells":"26.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"26.1","Neuronal cells":"26.7","Renal nephron cells":"36.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Rhabdoid":"3.5"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA047253":null,"HPA050490":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"}},{"Gene":"TMEM202","Gene synonym":["FLJ27523"],"Ensembl":"ENSG00000187806","Gene description":"Transmembrane protein 202","Uniprot":["A6NGA9"],"Chromosome":"15","Position":"72398302-72408367","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"115","RNA tissue specific nTPM":{"testis":"11.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"66.9","Late primary spermatocytes":"150.0","Late spermatids":"93.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"106","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"150.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045736"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoli fibrillar center","Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA045736":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.19e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.92e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"}},{"Gene":"TMEM215","Gene synonym":[],"Ensembl":"ENSG00000188133","Gene description":"Transmembrane protein 215","Uniprot":["Q68D42"],"Chromosome":"9","Position":"32783540-32789201","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"retina":"16.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"15","RNA single cell type specific nCPM":{"Early spermatids":"157.5","Late spermatids":"574.8","Retinal bipolar cells":"477.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"86","RNA single cell type group specific nCPM":{"Neuronal cells":"477.0","Spermatogenic cell types":"574.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"13.8","medium spiny neuron":"11.6","midbrain-derived inhibitory":"32.7"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"17","RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"8.0"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"hypothalamus":"13.8"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA063207"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA063207":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM217","Gene synonym":["C6orf128","dJ355M6.2"],"Ensembl":"ENSG00000172738","Gene description":"Transmembrane protein 217","Uniprot":["Q8N7C4"],"Chromosome":"6","Position":"37212180-37258155","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"3.6","Bergmann glia":"5.4","Brain inhibitory neurons":"2.7","Choroid plexus epithelial cells":"3.6","Distal convoluted tubule cells":"4.1","Ependymal cells":"5.9","Loop of henle epithelial cells":"7.8","Oligodendrocytes":"3.4","Other brain neurons":"3.1","Papillary tip epithelial cells":"6.9","Podocytes":"5.4","Proximal tubule cells":"8.8","Renal collecting duct intercalated cells":"4.2","Renal collecting duct principal cells":"5.2","Renal connecting tubule cells":"5.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"5.9","Ductal cells":"5.6","Glial cells":"5.4","Neuronal cells":"3.1","Renal nephron cells":"8.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045432","HPA071187"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA045432":null,"HPA071187":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.17e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059185":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.74e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-3"}},{"Gene":"TMEM225","Gene synonym":["PMP22CD","PPP1R154","SPATA47"],"Ensembl":"ENSG00000204300","Gene description":"Transmembrane protein 225","Uniprot":["Q6GV28"],"Chromosome":"11","Position":"123882920-123885670","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"205","RNA tissue specific nTPM":{"testis":"20.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"100.8","Late primary spermatocytes":"234.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"144","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"234.4"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM225B","Gene synonym":[],"Ensembl":"ENSG00000244219","Gene description":"Transmembrane protein 225B","Uniprot":["P0DP42"],"Chromosome":"7","Position":"99598267-99611045","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"34","RNA tissue specific nTPM":{"testis":"132.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late primary spermatocytes":"1154.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"165","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1154.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"3.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM231","Gene synonym":["ALYE870","FLJ22167","JBTS20","MKS11","PRO1886"],"Ensembl":"ENSG00000205084","Gene description":"Transmembrane protein 231","Uniprot":["Q9H6L2"],"Chromosome":"16","Position":"75536741-75556289","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Joubert syndrome","Meckel syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"choroid plexus":"38.2","fallopian tube":"69.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Ependymal cells":"79.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"79.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"110.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipose progenitor cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"32400604.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"6849316.9"},"Antibody":["HPA042081"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles","Mid piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":36,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Golgi apparatus","Mid piece"],"Antibody RRID":{"HPA042081":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"}},{"Gene":"TMEM232","Gene synonym":["FLJ43080"],"Ensembl":"ENSG00000186952","Gene description":"Transmembrane protein 232","Uniprot":["C9JQI7"],"Chromosome":"5","Position":"110289233-110738956","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"fallopian tube":"13.5","testis":"15.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"1197.0","Endometrial ciliated cells":"929.5","Ependymal cells":"3597.6","Epididymal efferent duct ciliated cells":"590.5","Fallopian tube ciliated cells":"866.2","Respiratory ciliated cells":"1964.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"3597.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"1117.6","ependymal cell":"3784.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA049386"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA049386":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"}},{"Gene":"TMEM233","Gene synonym":["DSPB2","IFITMD2"],"Ensembl":"ENSG00000224982","Gene description":"Transmembrane protein 233","Uniprot":["B4DJY2"],"Chromosome":"12","Position":"119593774-119643075","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"70.2","tongue":"19.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Mast cells":"236.6","Myonuclei":"307.5","Myosatellite cells":"113.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Mast cells":"236.6","Myocytes":"307.5","Stem cells":"113.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"35.9","LAMP5-LHX6 and Chandelier":"44.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"18.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Bone cancer":"1.5","Brain cancer":"1.5","Sarcoma":"5.7","thyroid cancer":"4.7"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047506","HPA075435"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047506":null,"HPA075435":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.27e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.12e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.32e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM247","Gene synonym":[],"Ensembl":"ENSG00000284701","Gene description":"Transmembrane protein 247","Uniprot":["A6NEH6"],"Chromosome":"2","Position":"46479565-46484425","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"32","RNA tissue specific nTPM":{"testis":"46.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"418.7","Late primary spermatocytes":"219.6","Late spermatids":"448.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"448.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"1.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA079482":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM249","Gene synonym":["C8orfK29"],"Ensembl":"ENSG00000261587","Gene description":"Transmembrane protein 249","Uniprot":["Q2WGJ8"],"Chromosome":"8","Position":"144352219-144354954","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"18","RNA tissue specific nTPM":{"testis":"26.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"3.3","Bergmann glia":"1.7","Brain excitatory neurons":"3.7","Brain inhibitory neurons":"3.1","Early spermatids":"3.0","Late primary spermatocytes":"3.2","Late spermatids":"6.9","Oligodendrocyte progenitor cells":"1.8","Other brain neurons":"2.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Glial cells":"3.3","Neuronal cells":"3.7","Spermatogenic cell types":"6.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Rhabdoid":"3.0"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA078901"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA078901":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Hepatocytes","Prostate - Prostate glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreas epithelial cells":"270761.2","Pancreatic islets":"341488.9"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA029105","HPA072613"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":35,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA029105":null,"HPA072613":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"TMEM262","Gene synonym":[],"Ensembl":"ENSG00000187066","Gene description":"Transmembrane protein 262","Uniprot":["E9PQX1"],"Chromosome":"11","Position":"65084979-65089375","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"152","RNA tissue specific nTPM":{"testis":"20.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"184.6","Late primary spermatocytes":"125.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"184.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM38B","Gene synonym":["bA219P18.1","C9orf87","D4Ertd89e","FLJ10493","TRIC-B"],"Ensembl":"ENSG00000095209","Gene description":"Transmembrane protein 38B","Uniprot":["Q9NVV0"],"Chromosome":"9","Position":"105694541-105776629","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Potassium transport","Transport"],"Molecular function":["Ion channel","Potassium channel"],"Disease involvement":["Osteogenesis imperfecta"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"70.8","tongue":"58.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"322.3","Late primary spermatocytes":"239.6","Late spermatids":"834.8","Myonuclei":"769.9","Thymic myoid cells":"213.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Myocytes":"769.9","Spermatogenic cell types":"834.8","Stromal cells":"213.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"135.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Distal tubules":"478927.1","Neutrophils":"974025.9"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"2279234.7","salivary gland":"3043972.2"},"Antibody":["HPA018465"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA018465":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.61e-12"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.82e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.27e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"}},{"Gene":"TMEM45A","Gene synonym":["DERP7","FLJ10134"],"Ensembl":"ENSG00000181458","Gene description":"Transmembrane protein 45A","Uniprot":["Q9NWC5"],"Chromosome":"3","Position":"100492619-100577444","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skin 1":"449.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"174.8","Decidual stromal cells":"704.2","Early spermatids":"223.0","Hepatocytes":"146.3","Lactotrophs":"112.7","Late primary spermatocytes":"137.9","Somatotrophs":"134.9","Suprabasal keratinocytes":"282.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"223.0","Stromal cells":"704.2","Suprabasal cells":"282.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"fibroblast":"59.3","oligodendrocyte precursor cell":"35.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Macrophages","Prostate - Fibroblasts","Skin - Keratinocyte (other)","Spleen - Fibroblasts_1","Stomach - Fibroblasts","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1890","Protein cell type specific Intensity":{"Keratinocytes":"189025.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA062101"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":7,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA062101":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.69e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.27e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"}},{"Gene":"TMEM52B","Gene synonym":["C12orf59","FLJ31166"],"Ensembl":"ENSG00000165685","Gene description":"Transmembrane protein 52B","Uniprot":["Q4KMG9"],"Chromosome":"12","Position":"10170542-10191804","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"23","RNA tissue specific nTPM":{"kidney":"105.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"1014.5","Epicardial cells":"725.5","Renal connecting tubule cells":"306.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"725.5","Ductal cells":"306.7","Renal nephron cells":"1014.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"23.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"120.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"liver cancer":"9.3"},"RNA tissue cell type enrichment":["Adrenal gland - Macrophages","Kidney - Intercalated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"2453","Protein cell type specific Intensity":{"Distal tubules":"245260.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA058096"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Focal adhesion sites"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":59,"Subcellular main location":["Focal adhesion sites"],"Subcellular additional location":null,"Antibody RRID":{"HPA058096":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM63C","Gene synonym":["C14orf171","CSC1","DKFZp434P0111","hsCSC1"],"Ensembl":"ENSG00000165548","Gene description":"Transmembrane protein 63C","Uniprot":["Q9P1W3"],"Chromosome":"14","Position":"77116568-77259495","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Ion transport","Transport"],"Molecular function":["Ion channel"],"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"53.9","pituitary gland":"39.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"21.3","Brain excitatory neurons":"23.9","Brain inhibitory neurons":"17.9","Corticotrophs":"26.6","Gonadotrophs":"37.5","Lactotrophs":"38.3","Neuroendocrine cells":"21.4","Oligodendrocyte progenitor cells":"18.5","Other brain neurons":"23.8","Pancreatic islet cells":"17.5","Retinal ganglion cells":"34.8","Retinal pigment epithelial cells":"25.6","Somatotrophs":"27.8","Thyrotrophs":"35.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enteroendocrine cells":"21.4","Neuronal cells":"34.8","Pigment cells":"25.6","Pituitary endocrine cells":"38.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"14.8"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Colon - Colon enteroendocrine cells","Heart muscle - Cardiomyocytes","Liver - Kupffer cells","Minor Salivary Gland - Minor salivary gland basal cells","Pancreas - Alpha cells","Pancreas - Beta cells","Spleen - Macrophages","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1482460.0","Pancreatic islets":"3211663.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5503","Protein tissue specific Intensity":{"cerebral cortex":"550261.5"},"Antibody":["HPA030657"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA030657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.15e-7"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.92e-4"}},{"Gene":"TMEM67","Gene synonym":["JBTS6","MGC26979","MKS3","NPHP11"],"Ensembl":"ENSG00000164953","Gene description":"Transmembrane protein 67","Uniprot":["Q5HYA8"],"Chromosome":"8","Position":"93754844-93819234","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Bardet-Biedl syndrome","Ciliopathy","Deafness","Disease variant","Intellectual disability","Joubert syndrome","Meckel syndrome","Nephronophthisis","Obesity","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"20.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"215.5","Ependymal cells":"532.9","Epididymal efferent duct ciliated cells":"144.8","Fallopian tube ciliated cells":"202.1","Respiratory ciliated cells":"327.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"532.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"599.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Vascular endothelial cells","Lung - Respiratory ciliated cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"2479263.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"9442","Protein tissue specific Intensity":{"fallopian tube":"944218.6"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":30,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.06e-6"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"}},{"Gene":"TMEM74B","Gene synonym":["C20orf46","FLJ11190"],"Ensembl":"ENSG00000125895","Gene description":"Transmembrane protein 74B","Uniprot":["Q9NUR3"],"Chromosome":"20","Position":"1180561-1185415","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"27.3","lung":"23.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"27.2","Breast lactating cells":"11.6","Enterocytes":"18.1","Fallopian tube ciliated cells":"23.1","Goblet cells":"18.5","Gonadotrophs":"17.6","Neuroendocrine cells":"17.9","Other brain neurons":"18.1","Pancreatic islet cells":"13.2","Parietal cells":"14.1","Pericytes":"20.8","Retinal ganglion cells":"27.0","Retinal horizontal cells":"12.0","Tuft cells":"46.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"23.1","Neuronal cells":"27.2","Secretory gland support":"46.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"195","Protein tissue specific Intensity":{"cerebral cortex":"19540.1"},"Antibody":["HPA045213"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 110: Mural cells - ECM organization","Interactions":null,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA045213":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.03e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.92e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.19e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"}},{"Gene":"TMEM81","Gene synonym":["HC3107","KVLA2788","MGC75217","UNQ2788"],"Ensembl":"ENSG00000174529","Gene description":"Transmembrane protein 81","Uniprot":["Q6P7N7"],"Chromosome":"1","Position":"205083129-205084460","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"15.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"12.3","Late primary spermatocytes":"14.7","Paneth cells":"7.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Secretory gland support":"7.7","Spermatogenic cell types":"14.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052515"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Intermediate filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA052515":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.88e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.24e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Perinuclear theca"],"Subcellular additional location":null,"Antibody RRID":{"HPA053577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMEM95","Gene synonym":["MGC129793","UNQ9390"],"Ensembl":"ENSG00000182896","Gene description":"Transmembrane protein 95","Uniprot":["Q3KNT9"],"Chromosome":"17","Position":"7355123-7357219","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Fertilization"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"101","RNA tissue specific nTPM":{"testis":"10.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"21","RNA single cell type specific nCPM":{"Early spermatids":"3.6","Late primary spermatocytes":"4.0","Late spermatids":"4.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"23","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"4.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMF1","Gene synonym":["ARA160","TMF"],"Ensembl":"ENSG00000144747","Gene description":"TATA element modulatory factor 1","Uniprot":["P82094"],"Chromosome":"3","Position":"69019827-69052339","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"522.7","Late spermatids":"891.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"891.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":5,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA008729":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.82e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"}},{"Gene":"TMIGD3","Gene synonym":["AD026"],"Ensembl":"ENSG00000121933","Gene description":"Transmembrane and immunoglobulin domain containing 3","Uniprot":["P0DMS9"],"Chromosome":"1","Position":"111483348-111563962","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"51.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"248.7","Hofbauer cells":"524.7","Kupffer cells":"364.9","Late primary spermatocytes":"478.0","Late spermatids":"142.6","Microglia":"152.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glial cells":"152.9","Mononuclear phagocytes":"524.7","Spermatogenic cell types":"478.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"50","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"181.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"4.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"44","RNA blood cell specific nTPM":{"eosinophil":"63.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"44","RNA blood lineage specific nTPM":{"granulocytes":"63.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"2.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 19: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.99e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.44e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMPRSS11A","Gene synonym":["ECRG1","HATL1","HESP"],"Ensembl":"ENSG00000187054","Gene description":"Transmembrane serine protease 11A","Uniprot":["Q6ZMR5"],"Chromosome":"4","Position":"67909395-67964140","Protein class":["Enzymes","Predicted membrane proteins","Transporters"],"Biological process":["Cell cycle"],"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"cervix":"33.6","esophagus":"80.9","lymphoid tissue":"26.7","vagina":"39.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Esophageal apical cells":"1411.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1411.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"25.2","Head and Neck Squamous Cell Carcinoma (TCGA)":"20.2","Lung Squamous Cell Carcinoma (TCGA)":"13.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Urothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"201","Protein cell type specific Intensity":{"Proximal tubules":"20065.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA078316"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA078316":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMPRSS11E","Gene synonym":["DESC1","TMPRSS11E2"],"Ensembl":"ENSG00000087128","Gene description":"Transmembrane serine protease 11E","Uniprot":["Q9UL52"],"Chromosome":"4","Position":"68447463-68497604","Protein class":["Enzymes","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"115.7","esophagus":"210.0","vagina":"156.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Esophageal apical cells":"676.3","Salivary ionocytes":"330.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"676.3","Ionocytes":"330.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"26.4","Head and Neck Squamous Cell Carcinoma (TCGA)":"30.0","Kidney Chromophobe (TCGA)":"26.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"8.2"},"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 49: Apical squamous epithelium - Epithelial barrier & keratinization","Interactions":2,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA043816":null,"HPA051062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - 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Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.00e-8"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TMPRSS12","Gene synonym":["CT151","MGC57341"],"Ensembl":"ENSG00000186452","Gene description":"Transmembrane serine protease 12","Uniprot":["Q86WS5"],"Chromosome":"12","Position":"50842920-50887884","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Fertilization","Spermatogenesis"],"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"50","RNA tissue specific nTPM":{"testis":"20.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Late primary spermatocytes":"271.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"23","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"271.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Ascending Loop of Henle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA040630":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"250000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 12: Smooth muscle tissue - ECM organization","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 62: Smooth muscle cells - Muscle contraction","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB004592":null,"HPA004823":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"}},{"Gene":"TNFAIP6","Gene synonym":["TSG-6","TSG6"],"Ensembl":"ENSG00000123610","Gene description":"TNF alpha induced protein 6","Uniprot":["P98066"],"Chromosome":"2","Position":"151357592-151380046","Protein class":["Plasma proteins","Predicted secreted proteins"],"Biological process":["Cell adhesion"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"urinary bladder":"181.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"567.8","Fibroblasts":"294.9","Late primary spermatocytes":"202.7","monocytes":"382.1","Neutrophil progenitors":"168.5","Neutrophils":"2232.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Fibroblasts":"294.9","Mononuclear phagocytes":"382.1","Neutrophils":"2232.9","Spermatogenic cell types":"567.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"16","RNA single nuclei brain specific nCPM":{"astrocyte":"12.4","committed oligodendrocyte precursor":"24.8","fibroblast":"7.4","oligodendrocyte":"7.8","oligodendrocyte precursor cell":"12.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"62.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"22","RNA blood cell specific nTPM":{"neutrophil":"183.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"22","RNA blood lineage specific nTPM":{"granulocytes":"183.6"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Bone cancer":"22.6","Kidney cancer":"58.1"},"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"830000","Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB032719":null,"HPA050884":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.59e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.55e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.85e-5"}},{"Gene":"TNFRSF17","Gene synonym":["BCM","BCMA","CD269","TNFRSF13A"],"Ensembl":"ENSG00000048462","Gene description":"TNF receptor superfamily member 17","Uniprot":["Q02223"],"Chromosome":"16","Position":"11965210-11968068","Protein class":["Cancer-related genes","CD markers","Disease related genes","FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":["Receptor"],"Disease involvement":["Cancer-related genes","FDA approved drug targets","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"27.3","lymphoid tissue":"44.8","stomach 1":"23.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"20","RNA single cell type specific nCPM":{"Plasma cells":"566.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Plasma cells":"566.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"63","RNA blood cell specific nTPM":{"memory B-cell":"125.4","naive B-cell":"109.1","plasmacytoid DC":"103.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"64","RNA blood lineage specific nTPM":{"B-cells":"125.4","dendritic cells":"103.5"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Myeloma":"608.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1300000","Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":4,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Mitotic spindle"],"Antibody RRID":{"HPA010569":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.93e-6"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.70e-6"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.56e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"TNFRSF21","Gene synonym":["CD358","DR6"],"Ensembl":"ENSG00000146072","Gene description":"TNF receptor superfamily member 21","Uniprot":["O75509"],"Chromosome":"6","Position":"47231532-47309905","Protein class":["CD markers","Plasma proteins","Predicted membrane proteins"],"Biological process":["Adaptive immunity","Apoptosis","Host-virus interaction","Immunity"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"108.8","urinary bladder":"138.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Kupffer cells":"236.8","Ocular epithelial cells":"323.3","Papillary tip epithelial cells":"358.7","Prostatic club cells":"338.6","Syncytiotrophoblasts":"274.7","Urothelial cells":"982.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"982.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"committed oligodendrocyte precursor":"280.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"35","RNA blood cell specific nTPM":{"plasmacytoid DC":"69.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"302","RNA blood lineage specific nTPM":{"dendritic cells":"69.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"350000","Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":4,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB009805":null,"HPA006746":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"}},{"Gene":"TNFSF11","Gene synonym":["CD254","ODF","OPGL","RANKL","TRANCE"],"Ensembl":"ENSG00000120659","Gene description":"TNF superfamily member 11","Uniprot":["O14788"],"Chromosome":"13","Position":"42562736-42608013","Protein class":["Cancer-related genes","CD markers","Disease related genes","FDA approved drug targets","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Differentiation"],"Molecular function":["Cytokine","Developmental protein","Receptor"],"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets","Osteopetrosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"3.9","lymphoid tissue":"11.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Innate lymphoid cells":"146.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Innate lymphoid cells":"146.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Pancreatic Adenocarcinoma (TCGA)":"5.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"NK-cell":"9.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"NK-cells":"9.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"1.5","thyroid cancer":"1.7"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":17200,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB009193":null,"HPA045142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TNIP3","Gene synonym":["ABIN-3","FLJ21162","LIND"],"Ensembl":"ENSG00000050730","Gene description":"TNFAIP3 interacting protein 3","Uniprot":["Q96KP6"],"Chromosome":"4","Position":"121131408-121227466","Protein class":["Predicted intracellular proteins"],"Biological process":["Inflammatory response"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"6.0","urinary bladder":"3.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"23.9","Endometrial secretory cells":"45.7","Late spermatids":"92.0","Macrophages":"23.6","monocytes":"199.8","NK-cells":"19.4","T-cells":"106.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"199.8","Secretory cells":"45.7","Spermatogenic cell types":"92.0","T-cells":"106.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"leukocyte":"44.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"memory CD8 T-cell":"6.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"T-cells":"6.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"5.9"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":31,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nuclear bodies","Plasma membrane"],"Antibody RRID":{"HPA043063":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"TNKS","Gene synonym":["ARTD5","PARP-5a","PARP5A","pART5","TIN1","TINF1","TNKS1"],"Ensembl":"ENSG00000173273","Gene description":"Tankyrase","Uniprot":["O95271"],"Chromosome":"8","Position":"9555912-9782346","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Cell cycle","Cell division","Mitosis","mRNA transport","Protein transport","Translocation","Transport","Wnt signaling pathway"],"Molecular function":["Glycosyltransferase","Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"228.6","Bergmann glia":"255.4","Brain excitatory neurons":"290.2","Brain inhibitory neurons":"351.3","Choroid plexus epithelial cells":"303.1","Distal convoluted tubule cells":"256.8","Ependymal cells":"311.1","Loop of henle epithelial cells":"209.0","Microglia":"187.7","Oligodendrocyte progenitor cells":"525.9","Oligodendrocytes":"389.3","Other brain neurons":"297.9","Podocytes":"326.5","Proximal tubule cells":"213.0","Renal collecting duct intercalated cells":"219.0","Renal collecting duct principal cells":"192.7","Renal connecting tubule cells":"257.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"311.1","Ductal cells":"257.6","Glial cells":"525.9","Neuronal cells":"351.3","Renal nephron cells":"326.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"49","Protein cell type specific Intensity":{"Microglia and Neuropil":"4938.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"51","Protein tissue specific Intensity":{"cerebral cortex":"5135.1"},"Antibody":["HPA025690"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":50,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear membrane","Nuclear bodies"],"Antibody RRID":{"HPA025690":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.64e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.84e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"}},{"Gene":"TNNI3K","Gene synonym":["CARK"],"Ensembl":"ENSG00000116783","Gene description":"TNNI3 interacting kinase","Uniprot":["Q59H18"],"Chromosome":"1","Position":"74235387-74544428","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Cardiomyopathy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"heart muscle":"54.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"67.7","Bergmann glia":"85.1","Brain excitatory neurons":"56.5","Brain inhibitory neurons":"48.1","Ependymal cells":"126.6","Microglia":"25.8","Oligodendrocyte progenitor cells":"58.4","Oligodendrocytes":"78.6","Other brain neurons":"29.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"21","RNA single cell type group specific nCPM":{"Ciliated cells":"126.6","Glial cells":"85.1","Neuronal cells":"56.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"616173.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"544572.5"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TNPO3","Gene synonym":["IPO12","LGMD1F","MTR10A","TRN-SR","TRN-SR2"],"Ensembl":"ENSG00000064419","Gene description":"Transportin 3","Uniprot":["Q9Y5L0"],"Chromosome":"7","Position":"128954180-129055173","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Limb-girdle muscular dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"430.1","Neutrophils":"481.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"481.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"5100","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":46,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA039555":null,"HPA072893":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 14: Oligodendrocyte progenitor cells - Development & myelination","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB022343":null,"HPA027134":null,"HPA027150":null,"HPA029859":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.02e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TOE1","Gene synonym":["hCaf1z","TOE-1"],"Ensembl":"ENSG00000132773","Gene description":"Target of EGR1, exonuclease","Uniprot":["Q96GM8"],"Chromosome":"1","Position":"45340052-45343973","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"45.9","Late primary spermatocytes":"78.2","Megakaryocytes":"49.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"49.5","Spermatogenic cell types":"78.2","Trophoblast cells":"45.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":28,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA053775":null,"HPA069119":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":22,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA001749":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.20e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"}},{"Gene":"TOM1L1","Gene synonym":["SRCASM"],"Ensembl":"ENSG00000141198","Gene description":"Target of myb1 like 1 membrane trafficking protein","Uniprot":["O75674"],"Chromosome":"17","Position":"54899387-54961956","Protein class":["Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"310.3","Retinal horizontal cells":"254.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"310.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Mesothelial cells","Adrenal gland - Adrenal cortex cells","Breast - Breast glandular cells","Liver - Hepatocytes","Skin - Mitotic cells (Skin)","Spleen - Fibroblasts_1","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"24987178.7"},"Antibody":["HPA022916"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA022916":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.45e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"}},{"Gene":"TOMM20L","Gene synonym":["UNQ9438"],"Ensembl":"ENSG00000196860","Gene description":"Translocase of outer mitochondrial membrane 20 like","Uniprot":["Q6UXN7"],"Chromosome":"14","Position":"58395928-58408702","Protein class":["Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"testis":"10.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Early spermatids":"133.0","Late primary spermatocytes":"129.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"133.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"1.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA076397":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TOMM22","Gene synonym":["TOM22"],"Ensembl":"ENSG00000100216","Gene description":"Translocase of outer mitochondrial membrane 22","Uniprot":["Q9NS69"],"Chromosome":"22","Position":"38681957-38685421","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":["Protein transport","Translocation","Transport"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"367.6","Esophageal suprabasal cells":"368.3","Extravillous trophoblasts":"262.5","Migrating cytotrophoblasts":"255.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"367.6","Suprabasal cells":"368.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"28000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":61,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA003037":null,"HPA074642":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TOP1MT","Gene synonym":[],"Ensembl":"ENSG00000184428","Gene description":"DNA topoisomerase I mitochondrial","Uniprot":["Q969P6"],"Chromosome":"8","Position":"143304384-143359979","Protein class":["Enzymes","FDA approved drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["DNA-binding","Isomerase","Topoisomerase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"60.4","Esophageal basal cells":"53.7","Late primary spermatocytes":"60.0","Undifferentiated spermatogonia":"52.0"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 106: Spermatogonia - Spermatogonial differentiation","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA001915":null,"HPA021542":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.10e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"}},{"Gene":"TOPBP1","Gene synonym":["Dpb11","KIAA0259","TOP2BP1"],"Ensembl":"ENSG00000163781","Gene description":"DNA topoisomerase II binding protein 1","Uniprot":["Q92547"],"Chromosome":"3","Position":"133598175-133662380","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"128.7","Late spermatids":"156.4","Monocyte progenitors":"170.4","Neutrophil progenitors":"204.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"170.4","Neutrophils":"204.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":59,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB022451":null,"HPA036738":null,"HPA036739":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.26e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.09e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.14e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"}},{"Gene":"TOR1AIP1","Gene synonym":["FLJ13142","LAP1","LAP1B","LAP1C"],"Ensembl":"ENSG00000143337","Gene description":"Torsin 1A interacting protein 1","Uniprot":["Q5JTV8"],"Chromosome":"1","Position":"179882042-179920077","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Limb-girdle muscular dystrophy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"386.9","Late spermatids":"288.5","Neutrophil progenitors":"288.8","Neutrophils":"262.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"288.8","Spermatogenic cell types":"386.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neutrophils":"140489942.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"35550435.8"},"Antibody":["HPA047151","HPA050546","HPA070991"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":39,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA047151":null,"HPA050546":null,"HPA070991":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.59e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"}},{"Gene":"TOR1B","Gene synonym":["DQ1","MGC4386"],"Ensembl":"ENSG00000136816","Gene description":"Torsin family 1 member B","Uniprot":["O14657"],"Chromosome":"9","Position":"129803157-129811281","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Chaperone","Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"78.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"78.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"1356234.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA013403","HPA013697","CAB022709"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"84000","Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":32,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB022709":null,"HPA013403":null,"HPA013697":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.46e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"}},{"Gene":"TOR2A","Gene synonym":["FLJ14771","TORP1"],"Ensembl":"ENSG00000160404","Gene description":"Torsin family 2 member A","Uniprot":["Q5JU69","Q8N2E6"],"Chromosome":"9","Position":"127731524-127735313","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"45.5","Early spermatids":"69.8","Esophageal apical cells":"43.3","Extravillous trophoblasts":"49.4","Hofbauer cells":"76.9","Late primary spermatocytes":"82.9","Syncytiotrophoblasts":"60.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"76.9","Spermatogenic cell types":"82.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"288428.9","Neutrophils":"244041.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1051893.9","lymphoid tissue":"1165208.4"},"Antibody":["HPA071229"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Endoplasmic reticulum","Plasma membrane"],"Secretome location":"Secreted to blood","Secretome function":"Hormone","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":5,"Subcellular main location":["Endoplasmic reticulum","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA071229":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.34e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"}},{"Gene":"TP53I3","Gene synonym":["PIG3"],"Ensembl":"ENSG00000115129","Gene description":"Tumor protein p53 inducible protein 3","Uniprot":["Q53FA7"],"Chromosome":"2","Position":"24077433-24085861","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"121.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Conjunctival goblet cells":"259.2","Enterocytes":"198.9","Esophageal apical cells":"897.4","Esophageal suprabasal cells":"220.3","Late primary spermatocytes":"176.1","Late spermatids":"296.3","Respiratory ionocytes":"170.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"897.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"15.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB017479","HPA022012","HPA028742"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"150000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":3,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB017479":null,"HPA022012":null,"HPA028742":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.32e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"}},{"Gene":"TP53RK","Gene synonym":["BUD32","C20orf64","dJ101A2.2","Nori-2p","prpk","TPRKB"],"Ensembl":"ENSG00000172315","Gene description":"TP53 regulating kinase","Uniprot":["Q96S44"],"Chromosome":"20","Position":"46684365-46689444","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Hydrolase","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"215.3","Extravillous trophoblasts":"93.1","Late primary spermatocytes":"227.4","Syncytiotrophoblasts":"115.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"227.4","Trophoblast cells":"115.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004688","HPA015837","HPA075054"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":22,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB004688":null,"HPA015837":null,"HPA075054":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.95e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.66e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":null,"Antibody RRID":{"HPA047832":null,"HPA060916":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Mitotic chromosome"],"Antibody RRID":{"HPA041979":null,"HPA058510":null,"HPA077455":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"}},{"Gene":"TPH2","Gene synonym":["FLJ37295","NTPH"],"Ensembl":"ENSG00000139287","Gene description":"Tryptophan hydroxylase 2","Uniprot":["Q8IWU9"],"Chromosome":"12","Position":"71938845-72186618","Protein class":["Disease related genes","Enzymes","FDA approved drug targets","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Serotonin biosynthesis"],"Molecular function":["Monooxygenase","Oxidoreductase"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Epicardial cells":"141.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"141.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"splatter":"28.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Group enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"midbrain":"631.8","pons":"271.3"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"2.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB078198":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"74000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":10,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA021545":null,"HPA021849":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.79e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"}},{"Gene":"TPP2","Gene synonym":["TPPII"],"Ensembl":"ENSG00000134900","Gene description":"Tripeptidyl peptidase 2","Uniprot":["P29144"],"Chromosome":"13","Position":"102596958-102679958","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Aminopeptidase","Hydrolase","Protease","Serine protease"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"825.6","Late primary spermatocytes":"624.4","Late spermatids":"1459.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1459.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"630000","Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":22,"Subcellular main location":["Nuclear bodies","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021069":null,"HPA049630":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"}},{"Gene":"TPPP3","Gene synonym":["CGI-38","p20","p25gamma"],"Ensembl":"ENSG00000159713","Gene description":"Tubulin polymerization promoting protein family member 3","Uniprot":["Q9BW30"],"Chromosome":"16","Position":"67389809-67393518","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"320.0","fallopian tube":"807.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"1037.8","Epididymal efferent duct ciliated cells":"2221.5","Fallopian tube ciliated cells":"1942.4","Melanocytes":"505.7","Respiratory ciliated cells":"1873.0","Suprabasal keratinocytes":"298.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"2221.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"315.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"66.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"58.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adrenal gland - Adrenal medulla cells","Colon - Enteric glia cells","Kidney - Podocytes","Lung - Respiratory ciliated cells","Minor Salivary Gland - Fibroblasts","Pituitary gland - Thyrotropes","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"301865321.1","Glomeruli":"164213173.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"296085131.1"},"Antibody":["HPA061691"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"48000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA061691":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.70e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.56e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.19e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"}},{"Gene":"TPR","Gene synonym":[],"Ensembl":"ENSG00000047410","Gene description":"Translocated promoter region, nuclear basket protein","Uniprot":["P12270"],"Chromosome":"1","Position":"186311652-186375693","Protein class":["Cancer-related genes","Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Cell cycle","Cell division","Mitosis","mRNA transport","Protein transport","Translocation","Transport"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Intellectual disability","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"662.1","Epicardial cells":"1373.6","Late primary spermatocytes":"644.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"1373.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019661","HPA019663","HPA024336"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":38,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA019661":null,"HPA019663":null,"HPA024336":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.35e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.85e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"}},{"Gene":"TPRG1","Gene synonym":["FAM79B","FLJ41238","FLJ43694"],"Ensembl":"ENSG00000188001","Gene description":"Tumor protein p63 regulated 1","Uniprot":["Q6ZUI0"],"Chromosome":"3","Position":"188947214-189325304","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"cervix":"28.2","esophagus":"49.1","vagina":"31.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Adipocytes":"751.8","Esophageal apical cells":"2784.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adipocytes":"751.8","Apical squamous epithelial cells":"2784.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"144.8","leukocyte":"108.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"45.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Esophageal cancer":"7.8","lymphoma":"10.1"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"11032","Protein cell type specific Intensity":{"Keratinocytes":"1103162.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044751","HPA060187"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":16,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044751":null,"HPA060187":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.53e-2"}},{"Gene":"TPRKB","Gene synonym":["CGI-121","CGI121"],"Ensembl":"ENSG00000144034","Gene description":"TP53RK binding protein","Uniprot":["Q9Y3C4"],"Chromosome":"2","Position":"73729104-73737400","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal efferent duct absorptive cells":"205.4","Late primary spermatocytes":"377.0","Megakaryocytes":"216.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"377.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"25969943.5"},"Antibody":["HPA035712"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":14,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035712":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.38e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.18e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.60e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.16e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.98e-6"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"}},{"Gene":"TPTE2","Gene synonym":["TPIP"],"Ensembl":"ENSG00000132958","Gene description":"Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2","Uniprot":["Q6XPS3"],"Chromosome":"13","Position":"19422876-19561625","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted membrane proteins"],"Biological process":["Lipid metabolism"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"6.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"25.1","Early primary spermatocytes":"134.5","Early spermatids":"29.5","Late primary spermatocytes":"113.2","Plasma cells":"36.2","Sertoli cells":"27.2","Undifferentiated spermatogonia":"26.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Plasma cells":"36.2","Spermatogenic cell types":"134.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"2.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"25","RNA cell line specific nTPM":{"Bone cancer":"22.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA068342"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Endoplasmic reticulum","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":9,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"HPA068342":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRABD2A","Gene synonym":["C2orf89","TIKI1"],"Ensembl":"ENSG00000186854","Gene description":"TraB domain containing 2A","Uniprot":["Q86V40"],"Chromosome":"2","Position":"84821650-84907008","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Hydrolase","Metalloprotease","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"intestine":"40.2","lymphoid tissue":"10.6","ovary":"38.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"609.7","Enteric stem cells":"198.3","Enteric transient amplifying cells":"121.6","Epicardial cells":"448.0","Late primary spermatocytes":"269.2","Late spermatids":"389.9","Ovarian stromal cells":"110.3","Plasma cells":"161.2","Thymocytes":"132.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"448.0","Spermatogenic cell types":"609.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"deep-layer intratelencephalic":"43.2","endothelial cell":"42.1","leukocyte":"53.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"66.4","Rectum Adenocarcinoma (TCGA)":"65.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"72.1"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"T-cells":"72.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"63.9","colorectal cancer":"35.7"},"RNA tissue cell type enrichment":["Spleen - T-cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"1893761.1","Macrophages":"649953.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"95784.4"},"Antibody":["HPA045817"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"19000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045817":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.12e-7"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"}},{"Gene":"TRAC","Gene synonym":[],"Ensembl":"ENSG00000277734","Gene description":"T cell receptor alpha constant","Uniprot":["P01848"],"Chromosome":"14","Position":"22547506-22552156","Protein class":["Disease related genes","Predicted membrane proteins","T-cell receptor genes"],"Biological process":["Adaptive immunity","Immunity"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"lymphoid tissue":"733.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"T-cells":"482.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"T-cells":"482.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"leukocyte":"258.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"5","RNA blood cell specific nTPM":{"MAIT T-cell":"2127.4","memory CD4 T-cell":"2948.4","memory CD8 T-cell":"2508.6","naive CD4 T-cell":"2680.8","naive CD8 T-cell":"2394.9","T-reg":"4391.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"41","RNA blood lineage specific nTPM":{"T-cells":"4391.5"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"132.6","lymphoma":"82.5"},"RNA tissue cell type enrichment":["Adipose visceral - T-cells","Adrenal gland - T-cells","Breast - T-cells","Colon - T-cells","Liver - T-cells","Lung - T-cells","Minor Salivary Gland - T-cells","Pancreas - T-cells","Pituitary gland - Corticotropes","Prostate - T-cells","Skeletal muscle - Fibroblasts","Spleen - T-cells","Stomach - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"}},{"Gene":"TRAF3IP1","Gene synonym":["DKFZP434F124","FAP116","IFT54","MIP-T3","MIPT3"],"Ensembl":"ENSG00000204104","Gene description":"TRAF3 interacting protein 1","Uniprot":["Q8TDR0"],"Chromosome":"2","Position":"238320441-238400897","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Leber congenital amaurosis","Nephronophthisis","Senior-Loken syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"356.5","Ependymal cells":"186.0","Fallopian tube ciliated cells":"344.3","Respiratory ciliated cells":"474.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"474.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"2.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"7880739.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"66533","Protein tissue specific Intensity":{"fallopian tube":"6653292.4"},"Antibody":["HPA037857","HPA037858"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center","Nuclear bodies","Primary cilium transition zone"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":32,"Subcellular main location":["Nuclear bodies","Primary cilium transition zone"],"Subcellular additional location":["Nucleoplasm","Nucleoli fibrillar center"],"Antibody RRID":{"HPA037857":null,"HPA037858":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.44e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.30e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"}},{"Gene":"TRAIP","Gene synonym":["RNF206","TRIP"],"Ensembl":"ENSG00000183763","Gene description":"TRAF interacting protein","Uniprot":["Q9BWF2"],"Chromosome":"3","Position":"49828601-49856574","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Dwarfism","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"13.7","Early primary spermatocytes":"17.5","Erythrocyte progenitors":"11.0","Extravillous trophoblasts":"10.7","Late primary spermatocytes":"12.6","Megakaryocyte progenitors":"11.4","Monocyte progenitors":"13.5","Oocytes":"41.4","Paneth cells":"11.6","Retinal amacrine cells":"12.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"41.4","Spermatogenic cell types":"17.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"16.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adrenal gland - Mitotic cells (Adrenal gland)","Kidney - Fibroblasts","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"basal ganglia":"14.2"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA036261","HPA036262"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":20,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036261":null,"HPA036262":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.61e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.86e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.61e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.33e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.26e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023929":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 44: Plasma cells - Antibody production & secretion","Interactions":1,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA035092":null,"HPA057925":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.01e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"}},{"Gene":"TRAPPC12","Gene synonym":["CGI-87","TTC-15","TTC15"],"Ensembl":"ENSG00000171853","Gene description":"Trafficking protein particle complex subunit 12","Uniprot":["Q8WVT3"],"Chromosome":"2","Position":"3379675-3485094","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Transport"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"94.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"100.3","Bergmann glia":"104.9","Brain inhibitory neurons":"91.1","Choroid plexus epithelial cells":"108.7","Distal convoluted tubule cells":"91.2","Early spermatids":"158.1","Late primary spermatocytes":"161.6","Late spermatids":"351.2","Microglia":"110.1","Oligodendrocyte progenitor cells":"106.3","Oligodendrocytes":"97.6","Proximal tubule cells":"96.3","Renal collecting duct intercalated cells":"121.5","Renal connecting tubule cells":"110.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"108.7","Ductal cells":"121.5","Glial cells":"110.1","Spermatogenic cell types":"351.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":23,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA034799":null,"HPA043196":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":13,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane","Centriolar satellite"],"Antibody RRID":{"HPA019359":null,"HPA029463":null,"HPA029464":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"}},{"Gene":"TRAPPC2B","Gene synonym":["MIP-2A","SEDLP","SEDLP1","TRAPPC2P1"],"Ensembl":"ENSG00000256060","Gene description":"Trafficking protein particle complex subunit 2B","Uniprot":["P0DI82"],"Chromosome":"19","Position":"57363551-57365405","Protein class":["Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Transcription","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"22.2","Endometrial secretory cells":"4.9","Gastric chief cells":"7.6","Late primary spermatocytes":"15.2","Megakaryocytes":"6.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"22.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":2,"Subcellular main location":["Endoplasmic reticulum","Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA063308":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.09e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"}},{"Gene":"TRAPPC2L","Gene synonym":["HSPC176"],"Ensembl":"ENSG00000167515","Gene description":"Trafficking protein particle complex subunit 2L","Uniprot":["Q9UL33"],"Chromosome":"16","Position":"88856220-88862686","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal suprabasal cells":"260.9","Hofbauer cells":"330.0","Late primary spermatocytes":"470.8","Late spermatids":"631.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"631.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":39,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA041714":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":41,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA028408":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.18e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.88e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.33e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"}},{"Gene":"TRAPPC3L","Gene synonym":["bA259P20.2","BET3L","FLJ11180"],"Ensembl":"ENSG00000173626","Gene description":"Trafficking protein particle complex subunit 3L","Uniprot":["Q5T215"],"Chromosome":"6","Position":"116494989-116545684","Protein class":["Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Platelets":"146.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Platelets":"146.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"3.2","hippocampal CA1-3":"3.2","lower rhombic lip":"6.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":null,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA060912":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRAPPC5","Gene synonym":["MGC52424","TRS31"],"Ensembl":"ENSG00000181029","Gene description":"Trafficking protein particle complex subunit 5","Uniprot":["Q8IUR0"],"Chromosome":"19","Position":"7680833-7687703","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["ER-Golgi transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"31.5","Brain inhibitory neurons":"29.8","Late spermatids":"52.7","Oligodendrocytes":"30.2","Other brain neurons":"42.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"42.3","Spermatogenic cell types":"52.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":null,"Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 80: Thymus - Adaptive immune response","Brain expression cluster":null,"Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRDN","Gene synonym":["TRISK"],"Ensembl":"ENSG00000186439","Gene description":"Triadin","Uniprot":["Q13061"],"Chromosome":"6","Position":"123216339-123637093","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"394.7","skeletal muscle":"1819.8","tongue":"951.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Cardiomyocytes":"11282.5","Myonuclei":"8756.3","Thymic myoid cells":"3855.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Myocytes":"11282.5","Stromal cells":"3855.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"ependymal cell":"549.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"7.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"22","RNA cell line specific nTPM":{"Rhabdoid":"16.0"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":17,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA038226":null,"HPA058226":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRGC2","Gene synonym":["TCRGC2","TRGC2(2X)","TRGC2(3X)"],"Ensembl":"ENSG00000227191","Gene description":"T cell receptor gamma constant 2","Uniprot":[],"Chromosome":"7","Position":"38239580-38249572","Protein class":["Predicted membrane proteins","T-cell receptor genes"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"26.1","lymphoid tissue":"30.0","prostate":"21.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"11.7","Early spermatids":"21.6","Innate lymphoid cells":"22.2","Late spermatids":"14.2","Monocyte progenitors":"24.0","Neutrophil progenitors":"36.4","NK-cells":"54.0","Prostatic glandular cells":"15.7","T-cells":"135.7","Thymocytes":"29.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"36.4","NK-cells":"54.0","T-cells":"135.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"92","RNA single nuclei brain specific nCPM":{"endothelial cell":"42.4","leukocyte":"126.1"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"17","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"193.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"459.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"T-cells":"459.6"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"30","RNA cell line specific nTPM":{"Leukemia":"41.5","prostate cancer":"10.5"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.95e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-1"}},{"Gene":"TRIL","Gene synonym":["KIAA0644"],"Ensembl":"ENSG00000255690","Gene description":"TLR4 interactor with leucine rich repeats","Uniprot":["Q7L0X0"],"Chromosome":"7","Position":"28953358-28958330","Protein class":["Predicted membrane proteins"],"Biological process":["Immunity","Inflammatory response","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"38.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"69.5","Bergmann glia":"62.0","Breast hormone-responsive cells":"12.1","Breast myoepithelial cells":"22.4","Ependymal cells":"62.7","Fibroblasts":"12.9","M\u00fcller glia":"18.3","Oligodendrocyte progenitor cells":"17.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"62.7","Glial cells":"69.5","Secretory gland support":"22.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"astrocyte":"81.9","Bergmann glia":"79.6","ependymal cell":"82.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"32.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"9.3","Neuroblastoma":"5.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 78: Brain - Neuronal signaling","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.28e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.27e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"}},{"Gene":"TRIM13","Gene synonym":["DLEU5","Leu5","RFP2","RNF77"],"Ensembl":"ENSG00000204977","Gene description":"Tripartite motif containing 13","Uniprot":["O60858"],"Chromosome":"13","Position":"49995888-50020481","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Immunity","Innate immunity","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"497.5","Epicardial cells":"354.8","Late primary spermatocytes":"681.6","Myonuclei":"328.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"354.8","Myocytes":"328.3","Spermatogenic cell types":"681.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"34556.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"338019.1"},"Antibody":["HPA000367"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA000367":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.43e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"}},{"Gene":"TRIM14","Gene synonym":["KIAA0129"],"Ensembl":"ENSG00000106785","Gene description":"Tripartite motif containing 14","Uniprot":["Q14142"],"Chromosome":"9","Position":"98069275-98119222","Protein class":["Predicted intracellular proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Kupffer cells":"294.1","Macrophages":"108.7","Monocyte progenitors":"108.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"294.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"106.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Adrenal gland - Macrophages","Heart muscle - Macrophages","Kidney - Proximal tubular cells","Prostate - Urothelial cells","Skeletal muscle - Macrophages","Spleen - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"4952444.7","Macrophages":"4170080.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"2037726.7","intestine":"2457965.1","liver":"4247843.3","lymphoid tissue":"2646843.8"},"Antibody":["HPA053217"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":38,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053217":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.88e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"}},{"Gene":"TRIM24","Gene synonym":["hTIF1","RNF82","TIF1","Tif1a"],"Ensembl":"ENSG00000122779","Gene description":"Tripartite motif containing 24","Uniprot":["O15164"],"Chromosome":"7","Position":"138460259-138589996","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["DNA-binding","Repressor","Transferase"],"Disease involvement":["Cancer-related genes","Tumor suppressor"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"316.4","Thymocytes":"277.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"5234107.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"523072.6"},"Antibody":["HPA043495","HPA061717"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 49: HMC-1 - Innate immune response","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":69,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043495":null,"HPA061717":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.39e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.69e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.59e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"}},{"Gene":"TRIM28","Gene synonym":["KAP-1","KAP1","PPP1R157","RNF96","TF1B","TIF1-beta","TIF1B","TIF1beta"],"Ensembl":"ENSG00000130726","Gene description":"Tripartite motif containing 28","Uniprot":["Q13263"],"Chromosome":"19","Position":"58544064-58550722","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Chromatin regulator","Repressor","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"300.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"300.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB010066","HPA064033"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":641,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB010066":null,"HPA064033":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.56e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.28e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.93e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":65,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA004345":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.57e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.51e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.84e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"}},{"Gene":"TRIM36","Gene synonym":["HAPRIN","RBCC728","RNF98"],"Ensembl":"ENSG00000152503","Gene description":"Tripartite motif containing 36","Uniprot":["Q9NQ86"],"Chromosome":"5","Position":"115124762-115180546","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"retina":"40.9","testis":"162.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"2529.3","Late spermatids":"7747.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"44","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"7747.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"13.9","Prostate Adenocarcinoma (TCGA)":"36.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"5.8","non-classical monocyte":"6.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"48","RNA blood lineage specific nTPM":{"dendritic cells":"5.8","granulocytes":"3.2","monocytes":"6.5"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"22.2"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Prostate - Prostate glandular cells","Stomach - Chief cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"8962355.3","Microglia and Neuropil":"9566758.9","Neurons":"8443652.3","Oocytes":"2455730.0"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"6353496.1","Stomach":"4031682.1"},"Antibody":["HPA004696"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":11,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA004696":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.17e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"}},{"Gene":"TRIM37","Gene synonym":["KIAA0898","MUL","POB1","TEF3"],"Ensembl":"ENSG00000108395","Gene description":"Tripartite motif containing 37","Uniprot":["O94972"],"Chromosome":"17","Position":"58982638-59106921","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Transcription","Ubl conjugation pathway"],"Molecular function":["Repressor","Transferase"],"Disease involvement":["Dwarfism","Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"58.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"225.6","Late primary spermatocytes":"193.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"225.6","Spermatogenic cell types":"193.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"30.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"30.5","T-cells":"8.3"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"154","Protein cell type specific Intensity":{"Neurons":"15357.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA021911"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":86,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA021911":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.73e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.08e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.97e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"}},{"Gene":"TRIM39","Gene synonym":["RNF23"],"Ensembl":"ENSG00000204599","Gene description":"Tripartite motif containing 39","Uniprot":["Q9HCM9"],"Chromosome":"6","Position":"30326479-30343729","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Apoptosis","Cell cycle","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Astrocytes":"6.9","Bergmann glia":"6.6","Brain excitatory neurons":"5.3","Brain inhibitory neurons":"5.6","Choroid plexus epithelial cells":"12.3","Ependymal cells":"15.2","Microglia":"6.7","Oligodendrocyte progenitor cells":"6.1","Oligodendrocytes":"6.4","Other brain neurons":"5.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"15.2","Glial cells":"6.9","Neuronal cells":"5.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"207","Protein cell type specific Intensity":{"Neurons":"20685.8"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051120","HPA059496"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":53,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA051120":null,"HPA059496":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"}},{"Gene":"TRIM46","Gene synonym":["FLJ23229","TRIFIC"],"Ensembl":"ENSG00000163462","Gene description":"Tripartite motif containing 46","Uniprot":["Q7Z4K8"],"Chromosome":"1","Position":"155173787-155184971","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"brain":"21.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"20.3","Brain inhibitory neurons":"21.0","Breast lactating cells":"20.6","Epicardial cells":"25.0","Epididymal principal cells":"12.5","Late spermatids":"12.5","Oligodendrocytes":"10.7","Other brain neurons":"17.0","Retinal amacrine cells":"20.2","Retinal ganglion cells":"15.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"25.0","Neuronal cells":"21.0","Secretory cells":"20.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"9.7"},"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Pancreas - Alpha cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"65799","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"3645577.4","Microglia and Neuropil":"6591175.1","Neurons":"9503059.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"70724","Protein tissue specific Intensity":{"cerebral cortex":"7072391.5"},"Antibody":["HPA030391","HPA055583"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubule ends","Cytokinetic bridge","Mitotic spindle","Primary cilium transition zone","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":["Microtubule ends","Mitotic spindle","Primary cilium transition zone"],"Subcellular additional location":["Cytokinetic bridge","Centrosome","Cytosol"],"Antibody RRID":{"HPA030391":null,"HPA055583":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"}},{"Gene":"TRIM55","Gene synonym":["MURF-2","RNF29"],"Ensembl":"ENSG00000147573","Gene description":"Tripartite motif containing 55","Uniprot":["Q9BYV6"],"Chromosome":"8","Position":"66126896-66175485","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Muscle protein","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"heart muscle":"57.8","liver":"35.5","skeletal muscle":"27.7","tongue":"31.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"151.5","Endometrial ciliated cells":"289.3","Epididymal efferent duct absorptive cells":"77.5","Epididymal efferent duct ciliated cells":"429.8","Epididymal principal cells":"87.2","Fallopian tube ciliated cells":"69.2","Hepatocytes":"64.5","Myonuclei":"215.3","Myosatellite cells":"61.0","Thymic myoid cells":"134.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"429.8","Myocytes":"215.3","Stromal cells":"134.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"9.8","upper rhombic lip":"11.8"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"12.5","Kidney Renal Papillary Cell Carcinoma (TCGA)":"6.7","Liver Hepatocellular Carcinoma (TCGA)":"15.9"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebellum":"3.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Kidney cancer":"39.2","Rhabdoid":"58.1","testis cancer":"83.9"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":22,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA038793":null,"HPA053691":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.39e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.04e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"}},{"Gene":"TRIM58","Gene synonym":["BIA2"],"Ensembl":"ENSG00000162722","Gene description":"Tripartite motif containing 58","Uniprot":["Q8NG06"],"Chromosome":"1","Position":"247857187-247880138","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"30.3","thyroid gland":"14.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Erythrocytes":"477.6","Platelets":"1454.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Erythrocytes":"477.6","Platelets":"1454.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Thyroid Carcinoma (TCGA)":"7.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Adrenocortical cancer":"40.8"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023637":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.14e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"}},{"Gene":"TRIM59","Gene synonym":["Mrf1","RNF104","TRIM57","TSBF1"],"Ensembl":"ENSG00000213186","Gene description":"Tripartite motif containing 59","Uniprot":["Q8IWR1"],"Chromosome":"3","Position":"160432445-160485773","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"16.3","lymphoid tissue":"12.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"20","RNA single cell type specific nCPM":{"Oligodendrocytes":"390.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"20","RNA single cell type group specific nCPM":{"Glial cells":"390.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"479.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":26,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA017750":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 26: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoli fibrillar center","Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA049109":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA027420":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.35e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRIML1","Gene synonym":["FLJ36180","RNF209"],"Ensembl":"ENSG00000184108","Gene description":"Tripartite motif family like 1","Uniprot":["Q8N9V2"],"Chromosome":"4","Position":"188139441-188147743","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Developmental protein","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"110","RNA tissue specific nTPM":{"testis":"11.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"189.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"57","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"189.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"21204054.7"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"3843056.7"},"Antibody":["HPA036835","HPA045893"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":61,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA036835":null,"HPA045893":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.13e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.37e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.08e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"}},{"Gene":"TRIP13","Gene synonym":["16E1BP"],"Ensembl":"ENSG00000071539","Gene description":"Thyroid hormone receptor interactor 13","Uniprot":["Q15645"],"Chromosome":"5","Position":"892884-919357","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Meiosis","Oogenesis","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"27.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"65.5","Early primary spermatocytes":"115.3","Early spermatids":"153.1","Epididymal efferent duct ciliated cells":"44.9","Fallopian tube ciliated cells":"61.3","Late spermatids":"330.5","Respiratory ciliated cells":"89.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"89.2","Spermatogenic cell types":"330.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"8077106.5","Keratinocytes":"3217691.2","Neutrophils":"2862359.5","Oocytes":"10569517.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"822736.6","intestine":"1502815.7","lymphoid tissue":"565086.9"},"Antibody":["HPA005727","HPA053093"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear speckles","Cytosol","Acrosome","Equatorial segment","Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"54000","Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":108,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":["Cytosol","Acrosome","Equatorial segment","Principal piece"],"Antibody RRID":{"HPA005727":null,"HPA053093":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.72e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.84e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.40e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.56e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.29e-9"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.99e-6"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA023939":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.65e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.30e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"}},{"Gene":"TRMT1L","Gene synonym":["C1orf25"],"Ensembl":"ENSG00000121486","Gene description":"TRNA methyltransferase 1 like","Uniprot":["Q7Z2T5"],"Chromosome":"1","Position":"185118101-185157072","Protein class":["Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Methyltransferase","RNA-binding","Transferase","tRNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"166.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"166.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":46,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA026728":null,"HPA054464":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"}},{"Gene":"TRMT5","Gene synonym":["KIAA1393","TRM5"],"Ensembl":"ENSG00000126814","Gene description":"TRNA methyltransferase 5","Uniprot":["Q32P41"],"Chromosome":"14","Position":"60971441-60981170","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"251.7","Late primary spermatocytes":"140.4","Late spermatids":"57.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"251.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA000943":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.06e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"}},{"Gene":"TROAP","Gene synonym":["TASTIN"],"Ensembl":"ENSG00000135451","Gene description":"Trophinin associated protein","Uniprot":["Q12815"],"Chromosome":"12","Position":"49323236-49331731","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"48.3","lymphoid tissue":"34.3","testis":"27.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"68.0","Enteric transient amplifying cells":"34.9","Erythrocyte progenitors":"33.1","Esophageal basal cells":"49.6","Extravillous trophoblasts":"27.3","Gastric progenitor cells":"75.6","Hofbauer cells":"27.7","Late primary spermatocytes":"85.0","Late spermatids":"103.5","Megakaryocyte progenitors":"24.4","Migrating cytotrophoblasts":"24.6","Monocyte progenitors":"44.7","Oocytes":"27.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"49.6","Mononuclear phagocytes":"44.7","Proliferating cells":"75.6","Spermatogenic cell types":"103.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"8.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"T-cells":"8.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"125295","Protein tissue specific Intensity":{"heart muscle":"13924594.2","skeletal muscle":"11134413.4"},"Antibody":["HPA044102"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":33,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044102":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.36e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.02e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.28e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.65e-14"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.22e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.42e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.80e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.43e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.13e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"}},{"Gene":"TRPA1","Gene synonym":["ANKTM1"],"Ensembl":"ENSG00000104321","Gene description":"Transient receptor potential cation channel subfamily A member 1","Uniprot":["O75762"],"Chromosome":"8","Position":"72019917-72075584","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Sensory transduction","Transport"],"Molecular function":["Calcium channel","Ion channel"],"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"8.6","stomach 1":"9.7","urinary bladder":"25.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"49.1","Fibro-adipogenic progenitors":"40.1","Fibroblasts":"59.2","Goblet cells":"74.3","Late primary spermatocytes":"12.8","Myosatellite cells":"53.6","Pericytes":"23.7","Vascular smooth muscle cells":"22.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"49.1","Fibro-adipogenic progenitors":"40.1","Fibroblasts":"59.2","Goblet cells":"74.3","Stem cells":"53.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal dentate gyrus":"14.5","pericyte":"10.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"7.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"7.2"},"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"105418","Protein cell type specific Intensity":{"Capillaries":"10541807.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4267","Protein tissue specific Intensity":{"intestine":"426726.2"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 17: Intestine - Digestion","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRPC7","Gene synonym":[],"Ensembl":"ENSG00000069018","Gene description":"Transient receptor potential cation channel subfamily C member 7","Uniprot":["Q9HCX4"],"Chromosome":"5","Position":"136212745-136365545","Protein class":["Predicted membrane proteins","Voltage-gated ion channels"],"Biological process":["Calcium transport","Ion transport","Transport"],"Molecular function":["Calcium channel","Ion channel"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain inhibitory neurons":"24.7","Neuroendocrine cells":"20.1","Oocytes":"27.6","Other brain neurons":"33.6","Retinal bipolar cells":"132.8","Retinal ganglion cells":"50.2","Thyrotrophs":"42.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enteroendocrine cells":"20.1","Neuronal cells":"132.8","Oocytes":"27.6","Pituitary endocrine cells":"42.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"52.8","midbrain-derived inhibitory":"97.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Kidney - Proximal tubular cells","Kidney - Proximal tubular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB022592","HPA031126"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB022592":null,"HPA031126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRPM1","Gene synonym":["CSNB1C","LTRPC1","MLSN1"],"Ensembl":"ENSG00000134160","Gene description":"Transient receptor potential cation channel subfamily M member 1","Uniprot":["Q7Z4N2"],"Chromosome":"15","Position":"31001065-31161160","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Sensory transduction","Transport","Vision"],"Molecular function":["Ion channel","Ligand-gated ion channel","Receptor"],"Disease involvement":["Congenital stationary night blindness","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"retina":"16.2","skin 1":"4.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Melanocytes":"201.7","Retinal bipolar cells":"275.6","Retinal pigment epithelial cells":"204.6"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neuronal cells":"275.6","Pigment cells":"204.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"oligodendrocyte":"62.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"263","RNA cancer specific pTPM":{"Skin Cutaneous Melanoma (TCGA)":"35.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"248","RNA cell line specific nTPM":{"skin cancer":"38.0"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":null,"Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":["Centriolar satellite"],"Subcellular additional location":["Golgi apparatus","Plasma membrane"],"Antibody RRID":{"HPA014779":null,"HPA071139":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRPM8","Gene synonym":[],"Ensembl":"ENSG00000144481","Gene description":"Transient receptor potential cation channel subfamily M member 8","Uniprot":["Q7Z2W7"],"Chromosome":"2","Position":"233917373-234019522","Protein class":["FDA approved drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters","Voltage-gated ion channels"],"Biological process":["Ion transport","Sensory transduction","Transport"],"Molecular function":["Ion channel"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"57","RNA tissue specific nTPM":{"liver":"29.4","prostate":"75.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Hepatocytes":"64.2","Prostatic club cells":"104.9","Prostatic glandular cells":"178.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Glandular cells":"178.5","Hepatocytes":"64.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"9.5"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"35","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"151.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Kidney cancer":"6.3","Myeloma":"7.1","prostate cancer":"13.1","skin cancer":"15.8"},"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 69: Skin cancer - ECM organization","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.18e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.66e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TRPS1","Gene synonym":["GC79","LGCR"],"Ensembl":"ENSG00000104447","Gene description":"Transcriptional repressor GATA binding 1","Uniprot":["Q9UHF7"],"Chromosome":"8","Position":"115408496-115809673","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"breast":"56.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"951.9","Astrocytes":"1204.8","Bergmann glia":"1533.6","Breast hormone-responsive cells":"1683.2","Breast secretory cells":"1051.5","Ependymal cells":"1106.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"1533.6","Luminal cells":"1683.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"108.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"classical monocyte":"4.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"breast cancer":"67.7"},"RNA tissue cell type enrichment":["Heart muscle - Fibroblasts","Prostate - Fibroblasts","Skeletal muscle - Fibroblasts","Skin - Outer root sheath cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"42262.2","Smooth muscle cells":"20029.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA060380","HPA071767"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA060380":null,"HPA071767":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.72e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.79e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"}},{"Gene":"TRPT1","Gene synonym":["MGC11134"],"Ensembl":"ENSG00000149743","Gene description":"TRNA phosphotransferase 1","Uniprot":["Q86TN4"],"Chromosome":"11","Position":"64223799-64226254","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["tRNA processing"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"166.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"137.8","Esophageal apical cells":"127.8","Goblet cells":"95.5","Late primary spermatocytes":"182.0","Late spermatids":"100.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"182.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":1,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA038705":null,"HPA038706":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.60e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.27e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.69e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.89e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"TSACC","Gene synonym":["C1orf182","SIP","SSTK-IP"],"Ensembl":"ENSG00000163467","Gene description":"TSSK6 activating cochaperone","Uniprot":["Q96A04"],"Chromosome":"1","Position":"156337314-156346995","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Chaperone"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"379","RNA tissue specific nTPM":{"testis":"879.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"6460.8","Late primary spermatocytes":"7373.3","Late spermatids":"29125.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"271","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"29125.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"16.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"basophil":"15.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"15.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":6,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA029897":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"}},{"Gene":"TSBP1","Gene synonym":["C6orf10","TSBP"],"Ensembl":"ENSG00000204296","Gene description":"Testis expressed basic protein 1","Uniprot":["Q5SRN2"],"Chromosome":"6","Position":"32288526-32371907","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"159","RNA tissue specific nTPM":{"testis":"33.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"19.6","Brain excitatory neurons":"11.2","Brain inhibitory neurons":"9.9","Early spermatids":"90.9","Late primary spermatocytes":"63.3","Late spermatids":"27.0","Oligodendrocyte progenitor cells":"13.0","Other brain neurons":"19.5","Renal collecting duct intercalated cells":"12.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"90.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA047479","HPA057426"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA047479":null,"HPA057426":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSGA10","Gene synonym":["CEP4L","CT79"],"Ensembl":"ENSG00000135951","Gene description":"Testis specific 10","Uniprot":["Q9BZW7"],"Chromosome":"2","Position":"98997261-99154964","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"48.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"282.4","Early spermatids":"404.9","Ependymal cells":"770.1","Fallopian tube ciliated cells":"367.3","Late primary spermatocytes":"532.7","Late spermatids":"372.3","Respiratory ciliated cells":"441.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"770.1","Spermatogenic cell types":"532.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"806.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":55,"Subcellular main location":["Flagellar centriole"],"Subcellular additional location":null,"Antibody RRID":{"HPA036879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"}},{"Gene":"TSGA10IP","Gene synonym":["FAM161C","FLJ32880"],"Ensembl":"ENSG00000175513","Gene description":"Testis specific 10 interacting protein","Uniprot":["Q3SY00"],"Chromosome":"11","Position":"65945480-65959966","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"12","RNA tissue specific nTPM":{"testis":"9.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"47.7","Late primary spermatocytes":"47.9","Late spermatids":"89.0","Melanocytes":"33.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Pigment cells":"33.5","Spermatogenic cell types":"89.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.4"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":83,"Subcellular main location":["Mid piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA049510":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSGA13","Gene synonym":[],"Ensembl":"ENSG00000213265","Gene description":"Testis specific 13","Uniprot":["Q96PP4"],"Chromosome":"7","Position":"130668643-130687432","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"102","RNA tissue specific nTPM":{"testis":"12.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"384.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"195","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"384.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"2.6"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA022968":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSN","Gene synonym":["BCLF-1","REHF-1","TRSLN"],"Ensembl":"ENSG00000211460","Gene description":"Translin","Uniprot":["Q15631"],"Chromosome":"2","Position":"121737103-121767853","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["DNA-binding","Endonuclease","Hydrolase","Nuclease","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"224.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"224.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"680000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":19,"Subcellular main location":["Nucleoplasm","Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA059561":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.81e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.26e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"}},{"Gene":"TSNAXIP1","Gene synonym":["TXI1"],"Ensembl":"ENSG00000102904","Gene description":"Translin associated factor X interacting protein 1","Uniprot":["Q2TAA8"],"Chromosome":"16","Position":"67806765-67832148","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"8.1","testis":"19.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"34.7","Early primary spermatocytes":"35.0","Early spermatids":"102.7","Endometrial ciliated cells":"52.4","Ependymal cells":"63.1","Epicardial cells":"43.2","Epididymal efferent duct ciliated cells":"41.1","Fallopian tube ciliated cells":"71.5","Late primary spermatocytes":"123.8","Late spermatids":"286.4","Respiratory ciliated cells":"76.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"76.7","Spermatogenic cell types":"286.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"66.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"3.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA053516":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"}},{"Gene":"TSPAN19","Gene synonym":[],"Ensembl":"ENSG00000231738","Gene description":"Tetraspanin 19","Uniprot":["P0C672"],"Chromosome":"12","Position":"85014311-85036277","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"4.0","testis":"4.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Respiratory ciliated cells":"447.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"447.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"14.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"2.4","Prostate Adenocarcinoma (TCGA)":"2.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"1.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA057066"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA057066":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSPEAR","Gene synonym":["C21orf29","DFNB98","MGC11251","TSP-EAR"],"Ensembl":"ENSG00000175894","Gene description":"Thrombospondin type laminin G domain and EAR repeats","Uniprot":["Q8WU66"],"Chromosome":"21","Position":"44497893-44711572","Protein class":["Disease related genes","Human disease related genes","Predicted secreted proteins"],"Biological process":["Hearing"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Ectodermal dysplasia","Non-syndromic deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"1.7","pituitary gland":"2.3","testis":"2.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"30.2","Corticotrophs":"105.1","Early spermatids":"51.1","Gonadotrophs":"40.7","Lactotrophs":"19.4","Lymphatic endothelial cells":"53.7","Podocytes":"68.4","Somatotrophs":"24.4","Thyrotrophs":"119.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Endothelial cells":"53.7","Myocytes":"30.2","Pituitary endocrine cells":"119.8","Renal nephron cells":"68.4","Spermatogenic cell types":"51.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"14.0","eccentric medium spiny neuron":"9.7","medium spiny neuron":"14.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"2.8"},"RNA tissue cell type enrichment":["Pituitary gland - Thyrotropes","Stomach - Gastric enteroendocrine cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"olfactory bulb":"1.3"},"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"888748.0","Keratinocytes":"608110.2","Large ducts":"618886.5","Smooth muscle cells":"1134010.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB034203","CAB034204","HPA052995"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"Other","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB034203":null,"CAB034204":null,"HPA052995":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSPO2","Gene synonym":["BZRPL1","dJ34B21.2"],"Ensembl":"ENSG00000112212","Gene description":"Translocator protein 2","Uniprot":["Q5TGU0"],"Chromosome":"6","Position":"41042467-41044337","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Transport"],"Molecular function":["Receptor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"39","RNA tissue specific nTPM":{"bone marrow":"47.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"23","RNA single cell type specific nCPM":{"Erythrocyte progenitors":"31.6","Erythrocytes":"61.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"31","RNA single cell type group specific nCPM":{"Erythrocytes":"61.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"2.0"},"RNA tissue cell type enrichment":["Spleen - Erythrocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA060691","HPA066996"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":49,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA060691":null,"HPA066996":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSSC4","Gene synonym":[],"Ensembl":"ENSG00000184281","Gene description":"Tumor suppressing subtransferable candidate 4","Uniprot":["Q9Y5U2"],"Chromosome":"11","Position":"2400488-2403878","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"210.2","Late spermatids":"294.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"294.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"804193.2","T-cells":"1147444.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"2440283.5"},"Antibody":["HPA041801","HPA058763"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":33,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA041801":null,"HPA058763":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.34e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.35e-4"}},{"Gene":"TSSK1B","Gene synonym":["FKSG81","SPOGA4","STK22D","TSSK1"],"Ensembl":"ENSG00000212122","Gene description":"Testis specific serine kinase 1B","Uniprot":["Q9BXA7"],"Chromosome":"5","Position":"113432553-113434989","Protein class":["Enzymes","Predicted membrane proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"230","RNA tissue specific nTPM":{"testis":"51.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"2.9","Late spermatids":"9.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"28","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"9.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027827"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies","Centrosome","Basal body","Perinuclear theca","Principal piece","End piece","Annulus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":8,"Subcellular main location":["Nuclear bodies","Principal piece"],"Subcellular additional location":["Centrosome","Basal body","Perinuclear theca","End piece","Annulus"],"Antibody RRID":{"HPA027827":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TSSK4","Gene synonym":["C14orf20","STK22E"],"Ensembl":"ENSG00000139908","Gene description":"Testis specific serine kinase 4","Uniprot":["Q6SA08"],"Chromosome":"14","Position":"24205696-24208362","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein","Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"36.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"17","RNA single cell type specific nCPM":{"Early spermatids":"178.7","Late primary spermatocytes":"121.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"351","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"178.7"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA060660","HPA077103"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cell Junctions"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Cell Junctions"],"Subcellular additional location":null,"Antibody RRID":{"HPA060660":null,"HPA077103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TTBK2","Gene synonym":["KIAA0847","SCA11"],"Ensembl":"ENSG00000128881","Gene description":"Tau tubulin kinase 2","Uniprot":["Q6IQ55"],"Chromosome":"15","Position":"42738730-42920809","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":["Neurodegeneration","Spinocerebellar ataxia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"28.3"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"9714","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"1416755.4","Microglia and Neuropil":"542890.0","Neurons":"954407.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"1668","Protein tissue specific Intensity":{"cerebral cortex":"166808.1"},"Antibody":["HPA018113"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Primary cilium","Primary cilium transition zone","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":9,"Subcellular main location":["Microtubules","Cytosol"],"Subcellular additional location":["Primary cilium","Primary cilium transition zone","Basal body"],"Antibody RRID":{"HPA018113":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.91e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"}},{"Gene":"TTC12","Gene synonym":["FLJ13859","FLJ20535","TPARM"],"Ensembl":"ENSG00000149292","Gene description":"Tetratricopeptide repeat domain 12","Uniprot":["Q9H892"],"Chromosome":"11","Position":"113314579-113383544","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"48.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"115.7","Early spermatids":"158.4","Ependymal cells":"166.0","Late primary spermatocytes":"218.5","Late spermatids":"304.0","Respiratory ciliated cells":"137.8","Thyrotrophs":"123.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"166.0","Spermatogenic cell types":"304.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"170.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear membrane","Plasma membrane"],"Antibody RRID":{"HPA038542":null,"HPA038543":null,"HPA061364":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.08e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.53e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-5"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"}},{"Gene":"TTC16","Gene synonym":["FLJ32780"],"Ensembl":"ENSG00000167094","Gene description":"Tetratricopeptide repeat domain 16","Uniprot":["Q8NEE8"],"Chromosome":"9","Position":"127716079-127731590","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"10","RNA tissue specific nTPM":{"fallopian tube":"6.5","testis":"15.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"117.4","Late spermatids":"427.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"427.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"3.9","ependymal cell":"13.4","leukocyte":"10.2","oligodendrocyte precursor cell":"6.0"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"1.6","naive CD8 T-cell":"1.5"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"16","RNA blood lineage specific nTPM":{"T-cells":"1.6"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TTC21A","Gene synonym":["IFT139A","STI2","Thm2"],"Ensembl":"ENSG00000168026","Gene description":"Tetratricopeptide repeat domain 21A","Uniprot":["Q8NDW8"],"Chromosome":"3","Position":"39107680-39138903","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"43.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"128.3","Endometrial ciliated cells":"89.7","Ependymal cells":"156.0","Fallopian tube ciliated cells":"132.2","Late primary spermatocytes":"161.3","Late spermatids":"132.2","Respiratory ciliated cells":"256.0","Thyrotrophs":"84.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"256.0","Spermatogenic cell types":"161.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"156.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA035510":null,"HPA035511":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA035072":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037807":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":51,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Primary cilium","Mitochondria","Cytosol"],"Antibody RRID":{"HPA036338":null,"HPA061867":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.42e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"TTC27","Gene synonym":["FLJ20272"],"Ensembl":"ENSG00000018699","Gene description":"Tetratricopeptide repeat domain 27","Uniprot":["Q6P3X3"],"Chromosome":"2","Position":"32628032-32821051","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Megakaryocyte progenitors":"309.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"309.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":31,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA031246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.71e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.01e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.24e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.93e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"}},{"Gene":"TTC28","Gene synonym":["KIAA1043"],"Ensembl":"ENSG00000100154","Gene description":"Tetratricopeptide repeat domain 28","Uniprot":["Q96AY4"],"Chromosome":"22","Position":"27978014-28679840","Protein class":["Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Fibro-adipogenic progenitors":"907.5","Proximal tubule cells":"897.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"5627260.2","Smooth muscle cells":"3196410.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"blood vessel":"1979704.8","intestine":"687706.9"},"Antibody":["HPA001080"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":9,"Subcellular main location":["Microtubules","Cytokinetic bridge","Mitotic spindle"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA001080":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.62e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.65e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"}},{"Gene":"TTC29","Gene synonym":["NYD-SP14"],"Ensembl":"ENSG00000137473","Gene description":"Tetratricopeptide repeat domain 29","Uniprot":["Q8NA56"],"Chromosome":"4","Position":"146706617-146945882","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"fallopian tube":"18.8","testis":"67.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"687.2","Endometrial ciliated cells":"337.4","Ependymal cells":"1066.1","Epididymal efferent duct ciliated cells":"420.5","Fallopian tube ciliated cells":"431.5","Late primary spermatocytes":"823.5","Late spermatids":"633.1","Respiratory ciliated cells":"839.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"29","RNA single cell type group specific nCPM":{"Ciliated cells":"1066.1","Spermatogenic cell types":"823.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"9","RNA single nuclei brain specific nCPM":{"ependymal cell":"1149.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"HPA037006":null,"HPA061473":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"}},{"Gene":"TTC30A","Gene synonym":["FAP259","FLJ13946","IFT70A"],"Ensembl":"ENSG00000197557","Gene description":"Tetratricopeptide repeat domain 30A","Uniprot":["Q86WT1"],"Chromosome":"2","Position":"177612999-177618742","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"34.6","Fallopian tube ciliated cells":"20.6","Late primary spermatocytes":"122.7","Respiratory ciliated cells":"31.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Ciliated cells":"31.9","Spermatogenic cell types":"122.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"17.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"10604957.1","Fallopian tube cells":"14394123.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"29961","Protein tissue specific Intensity":{"fallopian tube":"2996123.1"},"Antibody":["HPA051714","HPA052100","HPA052487"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Primary cilium","Primary cilium tip","Centrosome","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":59,"Subcellular main location":["Primary cilium","Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Primary cilium tip"],"Antibody RRID":{"HPA051714":null,"HPA052100":null,"HPA052487":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"TTC30B","Gene synonym":["fleer","FLJ30990","IFT70B"],"Ensembl":"ENSG00000196659","Gene description":"Tetratricopeptide repeat domain 30B","Uniprot":["Q8N4P2"],"Chromosome":"2","Position":"177548998-177552796","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"17.4","Early primary spermatocytes":"15.3","Endometrial ciliated cells":"16.6","Ependymal cells":"18.0","Fallopian tube ciliated cells":"33.7","Late primary spermatocytes":"30.3","Respiratory ciliated cells":"54.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"54.0","Spermatogenic cell types":"30.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"25.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":84,"Subcellular main location":["Primary cilium","Centrosome","Basal body"],"Subcellular additional location":["Nucleoplasm","Primary cilium tip"],"Antibody RRID":{"HPA051714":null,"HPA052100":null,"HPA052487":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.42e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"}},{"Gene":"TTC34","Gene synonym":[],"Ensembl":"ENSG00000215912","Gene description":"Tetratricopeptide repeat domain 34","Uniprot":["A8MYJ7"],"Chromosome":"1","Position":"2636986-2801693","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"5.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Ependymal cells":"250.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"24","RNA single cell type group specific nCPM":{"Ciliated cells":"250.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"17","RNA single nuclei brain specific nCPM":{"ependymal cell":"223.1"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA066832":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TTC39A","Gene synonym":["C1orf34","DEME-6","KIAA0452"],"Ensembl":"ENSG00000085831","Gene description":"Tetratricopeptide repeat domain 39A","Uniprot":["Q5SRH9"],"Chromosome":"1","Position":"51287258-51345116","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"52.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"492.0","Late primary spermatocytes":"215.2","Late spermatids":"910.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"910.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"thalamic excitatory":"35.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"101.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"47","RNA blood cell specific nTPM":{"plasmacytoid DC":"31.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"47","RNA blood lineage specific nTPM":{"dendritic cells":"31.8"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"65.1"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Colon enterocytes","Heart muscle - Cardiomyocytes","Kidney - Macrophages","Lung - Alveolar cells type 2","Prostate - Prostate glandular cells","Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2685094.8"},"Antibody":["HPA028098","HPA043440"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA028098":null,"HPA043440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 29: Forebrain - Mixed function","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA065705":null,"HPA065713":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.53e-6"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.88e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.81e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.58e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.34e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"}},{"Gene":"TTC4","Gene synonym":["CNS1","FLJ41930","MGC5097"],"Ensembl":"ENSG00000243725","Gene description":"Tetratricopeptide repeat domain 4","Uniprot":["O95801"],"Chromosome":"1","Position":"54715861-54742657","Protein class":["Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Antiviral defense","Immunity","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatic stellate cells":"6.5","Thyrotrophs":"7.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"5.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Enteric glia cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"ovary":"3372678.3"},"Antibody":["HPA041608","HPA042459"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Intermediate filaments","Cytoplasmic bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":29,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":["Cytoplasmic bodies"],"Antibody RRID":{"HPA041608":null,"HPA042459":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.56e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.91e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.34e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"TTC6","Gene synonym":["C14orf25","NCRNA00291"],"Ensembl":"ENSG00000139865","Gene description":"Tetratricopeptide repeat domain 6","Uniprot":["Q86TZ1"],"Chromosome":"14","Position":"37595629-38041442","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"breast":"4.0","prostate":"6.1","testis":"4.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"407.8","Ependymal cells":"949.0","Mucous neck cells":"212.1","Prostatic club cells":"237.3","Prostatic glandular cells":"1854.6","Respiratory basal cells":"226.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"949.0","Glandular cells":"1854.6","Luminal cells":"407.8"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"6","RNA single nuclei brain specific nCPM":{"ependymal cell":"1114.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"10.3","Prostate Adenocarcinoma (TCGA)":"20.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"prostate cancer":"11.3"},"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 16: Prostatic glandular cells - Androgen response & seminal fluid","Interactions":null,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA069293":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TTI2","Gene synonym":["C8orf41","FLJ23263"],"Ensembl":"ENSG00000129696","Gene description":"TELO2 interacting protein 2","Uniprot":["Q6NXR4"],"Chromosome":"8","Position":"33473386-33513185","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"72.8","Late primary spermatocytes":"77.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"1454662.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"675332.6"},"Antibody":["HPA023523","HPA029823"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":12,"Subcellular main location":["Centrosome"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA023523":null,"HPA029823":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.70e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.02e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"}},{"Gene":"TTK","Gene synonym":["CT96","MPH1","MPS1","MPS1L1"],"Ensembl":"ENSG00000112742","Gene description":"TTK protein kinase","Uniprot":["P33981"],"Chromosome":"6","Position":"80003887-80042527","Protein class":["Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"bone marrow":"23.9","lymphoid tissue":"43.4","testis":"32.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"45.7","Early primary spermatocytes":"51.3","Erythrocyte progenitors":"54.0","Late primary spermatocytes":"228.8","Megakaryocyte progenitors":"55.4","Megakaryocytes":"661.4","Monocyte progenitors":"79.1","Neutrophil progenitors":"46.0","Oocytes":"119.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"661.4","Oocytes":"119.7","Spermatogenic cell types":"228.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"13942","Protein cell type specific Intensity":{"Granulosa cells":"1144311.0","Oocytes":"1644011.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"2113","Protein tissue specific Intensity":{"bone marrow":"211293.1"},"Antibody":["CAB010166","CAB013229","HPA058657"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":null,"Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":17,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"CAB010166":null,"CAB013229":null,"HPA058657":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.12e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.97e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.96e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.17e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.11e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.06e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.10e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.11e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Basal body"],"Antibody RRID":{"HPA040133":null,"HPA041305":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TTLL4","Gene synonym":["KIAA0173"],"Ensembl":"ENSG00000135912","Gene description":"Tubulin tyrosine ligase like 4","Uniprot":["Q14679"],"Chromosome":"2","Position":"218710835-218755416","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"50.5","Bergmann glia":"64.8","Choroid plexus epithelial cells":"51.8","Early spermatids":"55.8","M\u00fcller glia":"91.0","Retinal pigment epithelial cells":"123.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"91.0","Pigment cells":"123.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"63.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 99: Retinal pigment epithelial cells - Retinol metabolism","Interactions":5,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA027091":null,"HPA050252":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.77e-4"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"}},{"Gene":"TTLL5","Gene synonym":["KIAA0998","STAMP"],"Ensembl":"ENSG00000119685","Gene description":"Tubulin tyrosine ligase like 5","Uniprot":["Q6EMB2"],"Chromosome":"14","Position":"75633625-75955079","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Transcription"],"Molecular function":["Ligase"],"Disease involvement":["Cone-rod dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"53.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"388.0","Cone photoreceptor cells":"511.3","Endometrial ciliated cells":"426.8","Ependymal cells":"491.2","Respiratory ciliated cells":"352.9","Rod photoreceptor cells":"477.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"491.2","Neuronal cells":"511.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":4,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA032128":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"}},{"Gene":"TTLL6","Gene synonym":["FLJ35808"],"Ensembl":"ENSG00000170703","Gene description":"Tubulin tyrosine ligase like 6","Uniprot":["Q8N841"],"Chromosome":"17","Position":"48762234-48817229","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"4.6","testis":"18.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"325.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"325.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"26.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"2.3"},"RNA tissue cell type enrichment":["Colon - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Microtubules","Primary cilium","Basal body","Flagellar centriole"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA052397":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TTLL7","Gene synonym":["FLJ23033"],"Ensembl":"ENSG00000137941","Gene description":"Tubulin tyrosine ligase like 7","Uniprot":["Q6ZT98"],"Chromosome":"1","Position":"83865024-83999150","Protein class":["Predicted intracellular proteins"],"Biological process":["Differentiation","Neurogenesis"],"Molecular function":["Developmental protein","Ligase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"blood vessel":"17.3","brain":"26.7"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Oligodendrocytes":"1906.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Glial cells":"1906.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"2322.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"3.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA052249":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Microtubules","Mid piece","Principal piece","End piece"],"Subcellular additional location":["Nucleoplasm","Mitotic spindle","Primary cilium","Basal body"],"Antibody RRID":{"HPA041772":null,"HPA055676":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"}},{"Gene":"TTR","Gene synonym":["CTS","CTS1","HsT2651","PALB"],"Ensembl":"ENSG00000118271","Gene description":"Transthyretin","Uniprot":["P02766"],"Chromosome":"18","Position":"31557009-31598833","Protein class":["Cancer-related genes","Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Transport"],"Molecular function":["Hormone","Thyroid hormone"],"Disease involvement":["Amyloidosis","Cancer-related genes","Disease variant","FDA approved drug targets","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"34","RNA tissue specific nTPM":{"choroid plexus":"672504.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Hepatocytes":"31024.8","Pancreatic islet cells":"53364.3","Retinal pigment epithelial cells":"61787.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Hepatocytes":"31024.8","Pancreatic islet cells":"53364.3","Pigment cells":"61787.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"40087.7"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"21","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"5122.1","Pancreatic Adenocarcinoma (TCGA)":"4235.1"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":"82","RNA brain regional specific nTPM":{"choroid plexus":"302089.2"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Gastric cancer":"130.8","liver cancer":"177.5"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":345000000000,"Blood concentration - Conc. blood MS [pg\/L]":"69000000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 1: Choroid plexus - Transmembrane transport","Brain expression cluster":"Cluster 36: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 76: Pancreatic endocrine cells - Endocrine signaling","Interactions":82,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB002517":null,"CAB062567":null,"CAB073406":null,"HPA002550":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - 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Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TUBA3C","Gene synonym":["bA408E5.3","TUBA2"],"Ensembl":"ENSG00000198033","Gene description":"Tubulin alpha 3c","Uniprot":["P0DPH7"],"Chromosome":"13","Position":"19173772-19181824","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"711","RNA tissue specific nTPM":{"testis":"390.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"274.5","Early primary spermatocytes":"526.7","Early spermatids":"627.4","Late primary spermatocytes":"1926.6","Late spermatids":"279.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"147","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1926.6"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"3.9"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bone cancer":"25.0","lymphoma":"21.8","Myeloma":"25.3"},"RNA tissue cell type enrichment":["Stomach - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":7,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"HPA039247":null,"HPA043684":null,"HPA063394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TUBA3D","Gene synonym":["H2-ALPHA"],"Ensembl":"ENSG00000075886","Gene description":"Tubulin alpha 3d","Uniprot":["P0DPH8"],"Chromosome":"2","Position":"131476119-131482934","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"16","RNA tissue specific nTPM":{"heart muscle":"82.4","testis":"211.7"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Differentiating spermatogonia":"258.2","Early primary spermatocytes":"593.4","Early spermatids":"299.1","Late primary spermatocytes":"922.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"18","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"922.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"15.3","Testicular Germ Cell Tumor (TCGA)":"11.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004972","HPA039247","HPA043684","HPA063394"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Microtubules","Primary cilium"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Primary cilium"],"Antibody RRID":{"CAB004972":null,"HPA039247":null,"HPA043684":null,"HPA063394":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"}},{"Gene":"TUBB1","Gene synonym":["dJ543J19.4"],"Ensembl":"ENSG00000101162","Gene description":"Tubulin beta 1 class VI","Uniprot":["Q9H4B7"],"Chromosome":"20","Position":"59019429-59026654","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"8.0","lymphoid tissue":"4.0"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Platelets":"7732.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Platelets":"7732.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"17","RNA blood cell specific nTPM":{"basophil":"63.2","neutrophil":"26.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"24","RNA blood lineage specific nTPM":{"granulocytes":"63.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"2.6"},"RNA tissue cell type enrichment":["Kidney - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"1365887.4","Neutrophils":"3053293.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"350832143.1","lymphoid tissue":"600479014.0"},"Antibody":["CAB004286","HPA043640","HPA046280"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle","Primary cilium","Primary cilium tip","Basal body","Flagellar centriole","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000000","Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 29: Lymphoid tissue & Bone marrow - Innate immune response","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":19,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Primary cilium","Primary cilium tip","Basal body","Flagellar centriole","Principal piece","End piece"],"Antibody RRID":{"CAB004286":null,"HPA043640":null,"HPA046280":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TUBB4B","Gene synonym":["Beta2","TUBB2C"],"Ensembl":"ENSG00000188229","Gene description":"Tubulin beta 4B class IVb","Uniprot":["P68371"],"Chromosome":"9","Position":"137241287-137243707","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Deafness","Disease variant","FDA approved drug targets","Leber congenital amaurosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"2019.1","Esophageal apical cells":"2023.6","Fallopian tube ciliated cells":"2624.7","Late primary spermatocytes":"3642.4","Late spermatids":"4003.9","Respiratory ciliated cells":"2676.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2023.6","Ciliated cells":"2676.7","Spermatogenic cell types":"4003.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"488.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal cortex cells","Breast - Adipocytes (Breast)","Kidney - Macrophages","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"566032277.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"328190249.1"},"Antibody":["CAB010880","HPA043640","HPA046280"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Microtubules","Cytokinetic bridge","Mitotic spindle","Primary cilium","Primary cilium tip","Basal body","Flagellar centriole","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000000","Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":173,"Subcellular main location":["Microtubules"],"Subcellular additional location":["Cytokinetic bridge","Mitotic spindle","Primary cilium","Primary cilium tip","Basal body","Flagellar centriole","Principal piece","End piece"],"Antibody RRID":{"CAB010880":null,"HPA043640":null,"HPA046280":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.12e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"}},{"Gene":"TUBE1","Gene synonym":["dJ142L7.2","FLJ22589","TUBE"],"Ensembl":"ENSG00000074935","Gene description":"Tubulin epsilon 1","Uniprot":["Q9UJT0"],"Chromosome":"6","Position":"112070663-112087529","Protein class":["FDA approved drug targets","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"217.6","Hepatocytes":"102.3","Late primary spermatocytes":"216.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"217.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"544954.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"60","Protein tissue specific Intensity":{"liver":"6013.0"},"Antibody":["HPA032073","HPA032074"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 31: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA032073":null,"HPA032074":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.26e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"}},{"Gene":"TUBG1","Gene synonym":["TUBG","TUBGCP1"],"Ensembl":"ENSG00000131462","Gene description":"Tubulin gamma 1","Uniprot":["P23258"],"Chromosome":"17","Position":"42609641-42615238","Protein class":["Disease related genes","Essential proteins","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","FDA approved drug targets","Lissencephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"155.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"292.3","Early spermatids":"753.9","Erythrocyte progenitors":"183.6","Late primary spermatocytes":"424.4","Late spermatids":"709.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"753.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"33999286.8"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB004608","HPA043012"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Principal piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":82,"Subcellular main location":["Principal piece"],"Subcellular additional location":null,"Antibody RRID":{"CAB004608":null,"HPA043012":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.50e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.01e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"}},{"Gene":"TUBGCP4","Gene synonym":["76P","FLJ14797"],"Ensembl":"ENSG00000137822","Gene description":"Tubulin gamma complex associated protein 4","Uniprot":["Q9UGJ1"],"Chromosome":"15","Position":"43369221-43409771","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Intellectual disability","Primary microcephaly"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"78.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"13.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"2180520.9","intestine":"1595112.9"},"Antibody":["HPA043212"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":29,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA043212":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.27e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.01e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"}},{"Gene":"TUFM","Gene synonym":["EF-TuMT","EFTu"],"Ensembl":"ENSG00000178952","Gene description":"Tu translation elongation factor, mitochondrial","Uniprot":["P49411"],"Chromosome":"16","Position":"28842411-28846348","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Protein biosynthesis"],"Molecular function":["Elongation factor","Hydrolase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal basal cells":"529.6","Late spermatids":"1008.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1008.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA018991","HPA024087","CAB075730","CAB075731","CAB075732"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"550000","Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":71,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB075730":null,"CAB075731":null,"CAB075732":null,"HPA018991":null,"HPA024087":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.55e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"}},{"Gene":"TULP2","Gene synonym":["CT65","TUBL2"],"Ensembl":"ENSG00000104804","Gene description":"TUB like protein 2","Uniprot":["O00295"],"Chromosome":"19","Position":"48880965-48898744","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"31","RNA tissue specific nTPM":{"testis":"29.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"255.6","Endometrial luminal cells":"107.2","Epicardial cells":"122.8","Late primary spermatocytes":"299.6","Late spermatids":"373.0","Mast cells":"129.5","Medullary thymic epithelial cells":"108.0","Neutrophils":"240.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"240.2","Spermatogenic cell types":"373.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"vascular associated smooth muscle cell":"4.0"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"4.4"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"cerebral cortex":"6.4"},"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"13","RNA blood cell specific nTPM":{"plasmacytoid DC":"1.3"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"13","RNA blood lineage specific nTPM":{"dendritic cells":"1.3"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 50: Lymphoma - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":4,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA075828":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"TUSC1","Gene synonym":["CCDC89B","TSG-9"],"Ensembl":"ENSG00000198680","Gene description":"Tumor suppressor candidate 1","Uniprot":["Q2TAM9"],"Chromosome":"9","Position":"25676969-25678444","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epididymal clear cells":"112.3","Late primary spermatocytes":"294.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"112.3","Spermatogenic cell types":"294.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"45.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"88222.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051426"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA051426":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.47e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.10e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.96e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"}},{"Gene":"TUT7","Gene synonym":["FLJ13409","KIAA1711","PAPD6","TENT3B","ZCCHC6"],"Ensembl":"ENSG00000083223","Gene description":"Terminal uridylyl transferase 7","Uniprot":["Q5VYS8"],"Chromosome":"9","Position":"86287733-86354454","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"660.6","Endometrial luminal cells":"612.2","Esophageal apical cells":"473.3","monocytes":"433.2","Neutrophils":"1481.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1481.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"115.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"115.2","monocytes":"48.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA020615":null,"HPA020620":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.14e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 30: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":80,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030401":null,"HPA030402":null,"HPA030403":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":56,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA031844":null,"HPA031845":null,"HPA031846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.44e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.32e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.22e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.06e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"}},{"Gene":"TXNL4A","Gene synonym":["DIB1","DIM1","HsT161","SNRNP15","TXNL4","U5-15kD"],"Ensembl":"ENSG00000141759","Gene description":"Thioredoxin like 4A","Uniprot":["P83876"],"Chromosome":"18","Position":"79970813-80033949","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Deafness"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"323.1","Megakaryocytes":"327.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":51,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA076100":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.51e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.77e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.77e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"}},{"Gene":"TYMS","Gene synonym":["HsT422","TMS","TS","Tsase"],"Ensembl":"ENSG00000176890","Gene description":"Thymidylate synthetase","Uniprot":["P04818"],"Chromosome":"18","Position":"657653-673578","Protein class":["Cancer-related genes","Enzymes","FDA approved drug targets","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Nucleotide biosynthesis"],"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":["Cancer-related genes","Disease variant","Dyskeratosis congenita","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"83.5","lymphoid tissue":"105.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"116.8","Enteric transient amplifying cells":"123.0","Erythrocyte progenitors":"327.1","Esophageal basal cells":"111.6","Extravillous trophoblasts":"122.0","Hofbauer cells":"115.2","Late primary spermatocytes":"286.5","Megakaryocyte progenitors":"335.1","Megakaryocytes":"117.5","Migrating cytotrophoblasts":"143.6","Monocyte progenitors":"198.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"327.1","Megakaryocytes":"335.1","Mononuclear phagocytes":"198.2","Spermatogenic cell types":"286.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"28.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"14.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"NK-cells":"6.8","T-cells":"14.1"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"29211","Protein cell type specific Intensity":{"Granulosa cells":"2921105.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"360","Protein tissue specific Intensity":{"bone marrow":"36034.9"},"Antibody":["CAB002784","HPA074922"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB002784":null,"HPA074922":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.16e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.73e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.34e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.99e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-6"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.81e-6"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.64e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"}},{"Gene":"TYSND1","Gene synonym":["MGC34695","NET41"],"Ensembl":"ENSG00000156521","Gene description":"Trypsin like peroxisomal matrix peptidase 1","Uniprot":["Q2T9J0"],"Chromosome":"10","Position":"70137981-70146700","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Hydrolase","Protease","Serine protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"101.1","Late primary spermatocytes":"325.2","Late spermatids":"304.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"325.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Spleen - B-cells (Spleen)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"1896147.3","Proximal tubules":"887214.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"383507.2"},"Antibody":["HPA030304"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":5,"Subcellular main location":["Nucleoplasm","Centrosome"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA030304":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-6"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.41e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"}},{"Gene":"UAP1","Gene synonym":["AgX","AGX1","SPAG2"],"Ensembl":"ENSG00000117143","Gene description":"UDP-N-acetylglucosamine pyrophosphorylase 1","Uniprot":["Q16222"],"Chromosome":"1","Position":"162561722-162601240","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Immunity","Innate immunity"],"Molecular function":["Nucleotidyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"liver":"93.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"307.0","Fibroblasts":"395.8","Late primary spermatocytes":"314.1","Pancreatic acinar cells":"301.9","Salivary acinar cells":"302.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"fibroblast":"81.3","vascular associated smooth muscle cell":"178.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"9025989.3","Pancreas epithelial cells":"11706915.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA014659"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"34000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":1,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA014659":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.39e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.78e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"}},{"Gene":"UBAC1","Gene synonym":["GBDR1","KPC2","UBADC1"],"Ensembl":"ENSG00000130560","Gene description":"UBA domain containing 1","Uniprot":["Q9BSL1"],"Chromosome":"9","Position":"135932969-135961373","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"290.9","tongue":"159.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Erythrocyte progenitors":"373.7","Late spermatids":"340.5","Respiratory ciliated cells":"235.9","Thymic myoid cells":"407.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"373.7","Spermatogenic cell types":"340.5","Stromal cells":"407.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"70000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":42,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA005651":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.97e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.08e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.04e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"}},{"Gene":"UBAP1","Gene synonym":["UBAP"],"Ensembl":"ENSG00000165006","Gene description":"Ubiquitin associated protein 1","Uniprot":["Q9NZ09"],"Chromosome":"9","Position":"34179005-34252523","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"820.0","Neutrophils":"2090.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"2090.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"1889122.4","Proximal tubules":"2843671.6"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019804"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":11,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Vesicles","Plasma membrane"],"Antibody RRID":{"HPA019804":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.34e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.21e-6"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"}},{"Gene":"UBAP2","Gene synonym":["bA176F3.5","FLJ22435","KIAA1491"],"Ensembl":"ENSG00000137073","Gene description":"Ubiquitin associated protein 2","Uniprot":["Q5T6F2"],"Chromosome":"9","Position":"33921693-34049388","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"92.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"1125810.1","Proximal tubules":"848229.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"4479177.2"},"Antibody":["HPA021684"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":33,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021684":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.59e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.23e-10"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.66e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.89e-5"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":89,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Acrosome","Equatorial segment"],"Antibody RRID":{"CAB013048":null,"HPA041344":null,"HPA049132":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.13e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.22e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.94e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"}},{"Gene":"UBC","Gene synonym":[],"Ensembl":"ENSG00000150991","Gene description":"Ubiquitin C","Uniprot":["P0CG48"],"Chromosome":"12","Position":"124911604-124917368","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"4803.4","Esophageal apical cells":"12836.8","Late spermatids":"5575.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"12836.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"676.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB000362","CAB005419","HPA041344","HPA049132"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cytosol","Acrosome","Equatorial segment"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":561,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Acrosome","Equatorial segment"],"Antibody RRID":{"CAB000362":null,"CAB005419":null,"HPA041344":null,"HPA049132":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.94e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"}},{"Gene":"UBE2C","Gene synonym":["UBCH10"],"Ensembl":"ENSG00000175063","Gene description":"Ubiquitin conjugating enzyme E2 C","Uniprot":["O00762"],"Chromosome":"20","Position":"45812576-45816957","Protein class":["Cancer-related genes","Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"74.0","lymphoid tissue":"105.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"134.4","Enteric transient amplifying cells":"232.5","Esophageal basal cells":"179.4","Extravillous trophoblasts":"511.3","Gastric progenitor cells":"528.0","Hofbauer cells":"143.6","Megakaryocyte progenitors":"337.6","Megakaryocytes":"680.0","Migrating cytotrophoblasts":"260.1","Monocyte progenitors":"158.8","Oocytes":"497.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Megakaryocytes":"680.0","Oocytes":"497.3","Proliferating cells":"528.0","Trophoblast cells":"511.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"T-reg":"8.2"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"2.1","NK-cells":"2.1","T-cells":"8.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Colon - Mitotic cells (Colon)","Heart muscle - Mitotic cells (Heart)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Thyroid gland - Mitotic cells (Thyroid)"],"RNA mouse brain regional specificity":"Group enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"basal ganglia":"4.3","white matter":"11.5"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"3154285.4"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1878","Protein tissue specific Intensity":{"bone marrow":"290764.0","intestine":"84782.8"},"Antibody":["CAB011464","HPA034569","CAB035990","HPA054975","CAB080407"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"Yes","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":15,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"CAB011464":null,"CAB035990":null,"CAB080407":null,"HPA034569":null,"HPA054975":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.67e-13"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.92e-7"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.33e-12"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.02e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.88e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.61e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.59e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.28e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.97e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"}},{"Gene":"UBE2D2","Gene synonym":["UBC4","UbcH5B"],"Ensembl":"ENSG00000131508","Gene description":"Ubiquitin conjugating enzyme E2 D2","Uniprot":["P62837"],"Chromosome":"5","Position":"139526431-139628434","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"2797.5","Endometrial glandular cells":"2919.2","Endometrial luminal cells":"1480.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"2797.5","Glandular cells":"2919.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"4938543.4"},"Antibody":["HPA003920"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":208,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA003920":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-5"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.65e-5"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.97e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.57e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.17e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"}},{"Gene":"UBE2J1","Gene synonym":["CGI-76","HSPC153","NCUBE1","UBC6"],"Ensembl":"ENSG00000198833","Gene description":"Ubiquitin conjugating enzyme E2 J1","Uniprot":["Q9Y385"],"Chromosome":"6","Position":"89326625-89352722","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"615.9","Late spermatids":"2044.0","Neutrophils":"523.8","Plasma cells":"780.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Plasma cells":"780.0","Spermatogenic cell types":"2044.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"226.1"},"RNA tissue cell type enrichment":["Kidney - Endothelial cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"1941933.8","T-cells":"1977613.0"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"3633154.5"},"Antibody":["HPA003509","CAB073419"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"27000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 34: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":61,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB073419":null,"HPA003509":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.26e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.64e-2"}},{"Gene":"UBE2L5","Gene synonym":["UBE2L5P"],"Ensembl":"ENSG00000236444","Gene description":"Ubiquitin conjugating enzyme E2 L5","Uniprot":["A0A1B0GUS4"],"Chromosome":"13","Position":"30422488-30429758","Protein class":["Enzymes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Ligase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"52","RNA tissue specific nTPM":{"testis":"43.1"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Late primary spermatocytes":"327.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"70","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"327.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Primary cilium transition zone"],"Antibody RRID":{"HPA045609":null,"HPA062415":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"UBE2M","Gene synonym":["hUbc12","UBC12"],"Ensembl":"ENSG00000130725","Gene description":"Ubiquitin conjugating enzyme E2 M","Uniprot":["P61081"],"Chromosome":"19","Position":"58555712-58558954","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"39000","Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":83,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli","Nuclear bodies","Cytosol"],"Antibody RRID":{"CAB004993":null,"HPA054551":null,"HPA057800":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.91e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1900000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":111,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA044976":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.68e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.68e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.59e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - 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Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"34810842.6","Cardiomyocytes":"82154645.6","Skeletal myofibers":"120075066.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA061000","HPA074334"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":13,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA061000":null,"HPA074334":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.98e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.12e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.00e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.60e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"}},{"Gene":"UBE2S","Gene synonym":["E2-EPF"],"Ensembl":"ENSG00000108106","Gene description":"Ubiquitin conjugating enzyme E2 S","Uniprot":["Q16763"],"Chromosome":"19","Position":"55399745-55407788","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"109.2","testis":"146.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast secretory cells":"296.6","Differentiating spermatogonia":"213.4","Innate lymphoid cells":"194.8","pDCs":"297.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"9236","Protein cell type specific Intensity":{"Granulosa cells":"923586.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"66647","Protein tissue specific Intensity":{"bone marrow":"6664679.5"},"Antibody":["CAB015228","HPA057150"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":30,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB015228":null,"HPA057150":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.45e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.85e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.46e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.80e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.27e-6"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.35e-5"},"Cancer prognostics - 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Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Minor Salivary Gland - Mitotic cells (Minor salivary gland)","Skin - Mitotic cells (Skin)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"16163","Protein cell type specific Intensity":{"Granulosa cells":"1616267.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"108633.4"},"Antibody":["HPA002831"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":13,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA002831":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"}},{"Gene":"UBE2U","Gene synonym":["MGC35130"],"Ensembl":"ENSG00000177414","Gene description":"Ubiquitin conjugating enzyme E2 U","Uniprot":["Q5VVX9"],"Chromosome":"1","Position":"64203623-64267368","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"testis":"30.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"213.2","Late primary spermatocytes":"174.4","Late spermatids":"445.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"445.5"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"26","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"24.2"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"choroid plexus":"1.4"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"UBE2V1","Gene synonym":["CROC-1","CROC1","UBE2V","UEV-1","UEV1A"],"Ensembl":"ENSG00000244687","Gene description":"Ubiquitin conjugating enzyme E2 V1","Uniprot":["Q13404"],"Chromosome":"20","Position":"50081124-50115959","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"51.2","Brain excitatory neurons":"62.7","Brain inhibitory neurons":"55.3","Esophageal apical cells":"57.3","Microglia":"57.3","Oligodendrocytes":"49.9","Other brain neurons":"64.4","Platelets":"54.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"2000000","Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 62: Non-specific - Plasma proteins","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":37,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA052535":null,"HPA053186":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.48e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.63e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.45e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"}},{"Gene":"UBE2V2","Gene synonym":["DDVit-1","DDVIT1","EDAF-1","EDPF-1","EDPF1","MMS2","UEV-2","UEV2"],"Ensembl":"ENSG00000169139","Gene description":"Ubiquitin conjugating enzyme E2 V2","Uniprot":["Q15819"],"Chromosome":"8","Position":"48008415-48064708","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"401.3","Esophageal suprabasal cells":"293.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"401.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Prostate - Smooth muscle cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052535","HPA053186"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1500000","Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 10: Brain - Synaptic signal transduction","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA052535":null,"HPA053186":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.07e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.33e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.97e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.50e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"}},{"Gene":"UBIAD1","Gene synonym":["SCCD","TERE1"],"Ensembl":"ENSG00000120942","Gene description":"UbiA prenyltransferase domain containing 1","Uniprot":["Q9Y5Z9"],"Chromosome":"1","Position":"11273198-11296049","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted membrane proteins"],"Biological process":["Menaquinone biosynthesis","Ubiquinone biosynthesis"],"Molecular function":["Prenyltransferase","Transferase"],"Disease involvement":["Corneal dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"788","Protein cell type specific Intensity":{"Pancreas epithelial cells":"98730.1","Pancreatic islets":"58867.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"165899.6"},"Antibody":["HPA044862"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":45,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA044862":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.86e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.81e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.22e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"}},{"Gene":"UBL3","Gene synonym":["DKFZP434K151","FLJ32018","HCG-1","PNSC1"],"Ensembl":"ENSG00000122042","Gene description":"Ubiquitin like 3","Uniprot":["O95164"],"Chromosome":"13","Position":"29764371-29850617","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1450.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1450.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Alveolar cells type 1","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"4953194.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA053772","HPA058781"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 9: T-regs - Cell cycle regulation","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":6,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA053772":null,"HPA058781":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.91e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"}},{"Gene":"UBL7","Gene synonym":["BMSC-UbP","MGC14421"],"Ensembl":"ENSG00000138629","Gene description":"Ubiquitin like 7","Uniprot":["Q96S82"],"Chromosome":"15","Position":"74445977-74461182","Protein class":["Predicted intracellular proteins"],"Biological process":["Antiviral defense","Immunity","Innate immunity","Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"48.0","Early spermatids":"56.3","Extravillous trophoblasts":"50.1","Late primary spermatocytes":"80.9","Late spermatids":"248.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"248.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040423":null,"HPA041897":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.95e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"}},{"Gene":"UBN1","Gene synonym":[],"Ensembl":"ENSG00000118900","Gene description":"Ubinuclein 1","Uniprot":["Q9NPG3"],"Chromosome":"16","Position":"4846665-4882401","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["Chromatin regulator","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"487.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"487.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"neutrophil":"14.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"8","RNA blood lineage specific nTPM":{"granulocytes":"14.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA061029":null,"HPA069036":null,"HPA069045":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.31e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.63e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"}},{"Gene":"UBN2","Gene synonym":["FLJ25778","KIAA2030"],"Ensembl":"ENSG00000157741","Gene description":"Ubinuclein 2","Uniprot":["Q6ZU65"],"Chromosome":"7","Position":"139230356-139308236","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"276.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"basophil":"8.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"granulocytes":"8.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"79","Protein tissue specific Intensity":{"intestine":"7907.9"},"Antibody":["HPA019743","HPA020122","HPA020124"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":18,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA019743":null,"HPA020122":null,"HPA020124":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.78e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"}},{"Gene":"UBQLN3","Gene synonym":["TUP-1"],"Ensembl":"ENSG00000175520","Gene description":"Ubiquilin 3","Uniprot":["Q9H347"],"Chromosome":"11","Position":"5507300-5509958","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"624","RNA tissue specific nTPM":{"testis":"151.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Early spermatids":"16.7","Late spermatids":"47.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"406","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"47.1"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA020547":null,"HPA062018":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"UBR7","Gene synonym":["C14orf130"],"Ensembl":"ENSG00000012963","Gene description":"Ubiquitin protein ligase E3 component n-recognin 7","Uniprot":["Q8N806"],"Chromosome":"14","Position":"93207241-93229215","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"16","RNA single cell type specific nCPM":{"Early spermatids":"295.2","Late primary spermatocytes":"158.3","Late spermatids":"477.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"25","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"477.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":23,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA000861":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.76e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.73e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.28e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"}},{"Gene":"UBXN1","Gene synonym":["2B28","LOC51035","SAKS1","UBXD10"],"Ensembl":"ENSG00000162191","Gene description":"UBX domain protein 1","Uniprot":["Q04323"],"Chromosome":"11","Position":"62676498-62679117","Protein class":["Predicted intracellular proteins"],"Biological process":["Host-virus interaction"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"497.1"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA012669","HPA076932"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"18000","Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 15: Non-specific - Protein processing","Interactions":34,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA012669":null,"HPA076932":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.85e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"}},{"Gene":"UBXN10","Gene synonym":["FLJ25429","UBXD3"],"Ensembl":"ENSG00000162543","Gene description":"UBX domain protein 10","Uniprot":["Q96LJ8"],"Chromosome":"1","Position":"20186096-20196050","Protein class":["Predicted intracellular proteins"],"Biological process":["Cilium biogenesis\/degradation"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"22.4","fallopian tube":"46.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"106.0","Endometrial ciliated cells":"87.9","Epididymal efferent duct ciliated cells":"70.1","Fallopian tube ciliated cells":"193.9","Late primary spermatocytes":"147.5","Late spermatids":"207.2","Respiratory ciliated cells":"209.1"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Ciliated cells":"209.1","Spermatogenic cell types":"207.2"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"Bergmann glia":"10.2","choroid plexus epithelial cell":"13.2","ependymal cell":"31.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"4.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gastric cancer":"3.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 70: DU4475 - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":16,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA028555":null,"HPA028564":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.59e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.02e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"}},{"Gene":"UBXN11","Gene synonym":["SOC","SOCI","UBXD5"],"Ensembl":"ENSG00000158062","Gene description":"UBX domain protein 11","Uniprot":["Q5T124"],"Chromosome":"1","Position":"26281328-26318363","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"131.3","Epididymal efferent duct ciliated cells":"157.4","Epididymal principal cells":"207.4","Fallopian tube ciliated cells":"161.6","Late primary spermatocytes":"117.3","Late spermatids":"542.7","Oocytes":"502.0","Respiratory ciliated cells":"173.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"502.0","Reproductive supporting cells":"207.4","Spermatogenic cell types":"542.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"100.7"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"classical monocyte":"94.2","intermediate monocyte":"83.1","myeloid DC":"48.8","non-classical monocyte":"73.8"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"dendritic cells":"48.8","monocytes":"94.2"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"1911497.9","Oocytes":"5711470.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"33890","Protein tissue specific Intensity":{"fallopian tube":"3388976.2"},"Antibody":["HPA028600","HPA031356"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":21,"Subcellular main location":["Basal body","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA028600":null,"HPA031356":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.81e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.08e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-3"}},{"Gene":"UBXN6","Gene synonym":["UBXD1","UBXDC2"],"Ensembl":"ENSG00000167671","Gene description":"UBX domain protein 6","Uniprot":["Q9BZV1"],"Chromosome":"19","Position":"4444999-4457794","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Late spermatids":"2483.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2483.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040906","HPA041313","HPA061872"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":179,"Subcellular main location":["Golgi apparatus","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA040906":null,"HPA041313":null,"HPA061872":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.52e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"}},{"Gene":"UBXN8","Gene synonym":["D8S2298E","REP8","UBXD6"],"Ensembl":"ENSG00000104691","Gene description":"UBX domain protein 8","Uniprot":["O00124"],"Chromosome":"8","Position":"30729131-30767006","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"117.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"241.0","Granulosa cells":"364.9","Hepatocytes":"89.2","Late spermatids":"290.5","Ovarian stromal cells":"152.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Reproductive supporting cells":"364.9","Spermatogenic cell types":"290.5","Stromal cells":"152.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"110328.4","Hepatocytes":"65260.6","Neurons":"71158.2","Proximal tubules":"65007.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"38","Protein tissue specific Intensity":{"liver":"3817.6"},"Antibody":["HPA017725","HPA077538"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Endoplasmic reticulum"],"Secretome location":"Intracellular and membrane","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 94: Gonadal somatic cells - Mixed function","Interactions":12,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":["Nucleoplasm","Nucleoli"],"Antibody RRID":{"HPA017725":null,"HPA077538":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.67e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.95e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.17e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"}},{"Gene":"UCHL3","Gene synonym":[],"Ensembl":"ENSG00000118939","Gene description":"Ubiquitin C-terminal hydrolase L3","Uniprot":["P15374"],"Chromosome":"13","Position":"75549480-75606020","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"170.6","Esophageal apical cells":"160.9","Esophageal basal cells":"133.3","Esophageal suprabasal cells":"203.6","Extravillous trophoblasts":"166.2","Late primary spermatocytes":"312.8","Syncytiotrophoblasts":"186.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"312.8","Suprabasal cells":"203.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019678","CAB037139","CAB037208"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"670000","Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":22,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"CAB037139":null,"CAB037208":null,"HPA019678":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.44e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.45e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.15e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"UCP3","Gene synonym":["SLC25A9"],"Ensembl":"ENSG00000175564","Gene description":"Uncoupling protein 3","Uniprot":["P55916"],"Chromosome":"11","Position":"74000277-74009085","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Transport"],"Molecular function":null,"Disease involvement":["Diabetes mellitus","Disease variant","Obesity"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"62","RNA tissue specific nTPM":{"skeletal muscle":"393.6","tongue":"245.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"19.8","Late spermatids":"20.2","Myonuclei":"34.4","Thymic myoid cells":"58.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Myocytes":"34.4","Spermatogenic cell types":"20.2","Stromal cells":"58.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB010771","HPA072225"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 21: Lymphoma - Adaptive immune response","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":2,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"CAB010771":null,"HPA072225":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.56e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"}},{"Gene":"UFC1","Gene synonym":["HSPC155"],"Ensembl":"ENSG00000143222","Gene description":"Ubiquitin-fold modifier conjugating enzyme 1","Uniprot":["Q9Y3C8"],"Chromosome":"1","Position":"161152776-161158856","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"774.5","Extravillous trophoblasts":"513.0","Fallopian tube ciliated cells":"596.0","Late spermatids":"636.7","Respiratory ciliated cells":"748.5","Syncytiotrophoblasts":"551.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"774.5","Ciliated cells":"748.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027481","HPA028722"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"65000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":22,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA027481":null,"HPA028722":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"}},{"Gene":"UFD1","Gene synonym":["UFD1L"],"Ensembl":"ENSG00000070010","Gene description":"Ubiquitin recognition factor in ER associated degradation 1","Uniprot":["Q92890"],"Chromosome":"22","Position":"19449911-19479202","Protein class":["Essential proteins","Predicted intracellular proteins","Transporters"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"386.3","Late spermatids":"335.7","Syncytiotrophoblasts":"221.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"386.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030286","HPA030287"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"6300","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":30,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA030286":null,"HPA030287":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.95e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.91e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.57e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"}},{"Gene":"UFSP2","Gene synonym":["C4orf20","FLJ11200"],"Ensembl":"ENSG00000109775","Gene description":"UFM1 specific peptidase 2","Uniprot":["Q9NUQ7"],"Chromosome":"4","Position":"185399537-185425979","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":["Disease variant","Dwarfism","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"213.8","Late primary spermatocytes":"263.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"213.8","Spermatogenic cell types":"263.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":38,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039985":null,"HPA043298":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.19e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.81e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.33e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":null,"Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Endoplasmic reticulum"],"Antibody RRID":{"CAB009819":null,"HPA054065":null,"HPA056023":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.79e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-3"},"Cancer prognostics - 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Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"}},{"Gene":"UGT2B10","Gene synonym":[],"Ensembl":"ENSG00000109181","Gene description":"UDP glucuronosyltransferase family 2 member B10","Uniprot":["P36537"],"Chromosome":"4","Position":"68815994-68832023","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"148","RNA tissue specific nTPM":{"liver":"218.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Hepatocytes":"14.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Hepatocytes":"14.2"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"132","RNA cancer specific pTPM":{"Liver Hepatocellular Carcinoma (TCGA)":"40.7"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"liver cancer":"2.1"},"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 53: Liver - Plasma proteins","Brain expression cluster":null,"Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 25: Hepatocytes - Plasma protein synthesis & secretion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA045108":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"UGT3A1","Gene synonym":["FLJ34658"],"Ensembl":"ENSG00000145626","Gene description":"UDP glycosyltransferase family 3 member A1","Uniprot":["Q6NUS8"],"Chromosome":"5","Position":"35951006-36001028","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"kidney":"47.6","liver":"54.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"122.6","Gonadotrophs":"21.0","Hepatocytes":"86.6","Late primary spermatocytes":"111.8","Late spermatids":"26.0","Myonuclei":"19.4","Proximal tubule cells":"48.7","Renal collecting duct principal cells":"36.0","Renal connecting tubule cells":"17.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"36.0","Hepatocytes":"86.6","Renal nephron cells":"48.7","Spermatogenic cell types":"122.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"lower rhombic lip":"1.6"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Kidney Renal Clear Cell Carcinoma (TCGA)":"11.5","Kidney Renal Papillary Cell Carcinoma (TCGA)":"9.5","Liver Hepatocellular Carcinoma (TCGA)":"12.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Kidney cancer":"2.5","Sarcoma":"1.4"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 16: Liver & Kidney - Metabolism","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":1,"Subcellular main location":["Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA047697":null,"HPA056290":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ULK2","Gene synonym":["ATG1B","KIAA0623","Unc51.2"],"Ensembl":"ENSG00000083290","Gene description":"Unc-51 like autophagy activating kinase 2","Uniprot":["Q8IYT8"],"Chromosome":"17","Position":"19770829-19867936","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Autophagy","Neurogenesis"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Microglia":"134.8"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"intermediate monocyte":"4.0","non-classical monocyte":"3.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"monocytes":"4.0"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"testis cancer":"40.3"},"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 36: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB037021":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.50e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.47e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.80e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.64e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.03e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.86e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.21e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"}},{"Gene":"ULK4","Gene synonym":["FAM7C1","FLJ20574","REC01035"],"Ensembl":"ENSG00000168038","Gene description":"Unc-51 like kinase 4","Uniprot":["Q96C45"],"Chromosome":"3","Position":"41246599-41962130","Protein class":["Disease related genes","Enzymes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"21.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"639.7","Decidual stromal cells":"2242.6","Endometrial ciliated cells":"1030.7","Ependymal cells":"1531.4","Fallopian tube ciliated cells":"726.6","Late spermatids":"699.1","Respiratory ciliated cells":"1485.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"1531.4","Stromal cells":"2242.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"580.0","ependymal cell":"1660.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"24187","Protein cell type specific Intensity":{"Fallopian tube cells":"3869917.7","Oocytes":"967542.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"47547","Protein tissue specific Intensity":{"fallopian tube":"4754719.5"},"Antibody":["HPA017930"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Primary cilium transition zone","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":2,"Subcellular main location":["Primary cilium transition zone","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA017930":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA067245":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":13,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus","Intermediate filaments"],"Antibody RRID":{"HPA024493":null,"HPA062300":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.90e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.07e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - 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Breast glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"72730676.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"8486","Protein tissue specific Intensity":{"kidney":"848581.6"},"Antibody":["HPA015725"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 68: Foveolar cells - Mucosal defense","Interactions":5,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA015725":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.49e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.17e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042940":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"UNC79","Gene synonym":["KIAA1409"],"Ensembl":"ENSG00000133958","Gene description":"Unc-79 homolog, NALCN channel complex subunit","Uniprot":["Q9P2D8"],"Chromosome":"14","Position":"93333219-93707876","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"brain":"12.8","pituitary gland":"11.1","retina":"5.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"154.1","Bergmann glia":"126.6","Brain excitatory neurons":"588.9","Brain inhibitory neurons":"653.2","Ependymal cells":"245.9","Oligodendrocyte progenitor cells":"397.8","Oligodendrocytes":"218.3","Other brain neurons":"472.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"245.9","Glial cells":"397.8","Neuronal cells":"653.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"8.1","thyroid cancer":"2.5"},"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 27: Cerebellum - Synaptic function","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA071881":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"UPF3A","Gene synonym":["HUPF3A","RENT3A","UPF3"],"Ensembl":"ENSG00000169062","Gene description":"UPF3A regulator of nonsense mediated mRNA decay","Uniprot":["Q9H1J1"],"Chromosome":"13","Position":"114281601-114305817","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA transport","Nonsense-mediated mRNA decay","Transport"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"708.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"708.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.46e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"}},{"Gene":"UPK2","Gene synonym":["MGC138598","UP2","UPII"],"Ensembl":"ENSG00000110375","Gene description":"Uroplakin 2","Uniprot":["O00526"],"Chromosome":"11","Position":"118925164-118958559","Protein class":["Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"25","RNA tissue specific nTPM":{"urinary bladder":"61.6"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Urothelial cells":"138.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Barrier epithelial cells":"138.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"63","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"550.8"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bladder cancer":"35.8"},"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":null,"Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 69: Urothelial cells - Basic cellular functions","Interactions":71,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043312":null,"HPA061106":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"}},{"Gene":"UQCC2","Gene synonym":["bA6B20.2","C6orf125","Cbp6","M19","MGC14833","MNF1"],"Ensembl":"ENSG00000137288","Gene description":"Ubiquinol-cytochrome c reductase complex assembly factor 2","Uniprot":["Q9BRT2"],"Chromosome":"6","Position":"33694293-33711727","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"333.3","Late primary spermatocytes":"431.2","Late spermatids":"1702.3","Megakaryocytes":"364.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1702.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":17,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA039111":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.26e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"UQCR10","Gene synonym":["HSPC051","QCR9","UCCR7.2","UCRC"],"Ensembl":"ENSG00000184076","Gene description":"Ubiquinol-cytochrome c reductase, complex III subunit X","Uniprot":["Q9UDW1"],"Chromosome":"22","Position":"29767369-29770413","Protein class":["Metabolic proteins","Predicted membrane proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Hepatocytes":"1502.1","Late primary spermatocytes":"1219.4","Parietal cells":"2809.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"2809.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.19e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"UQCRB","Gene synonym":["QCR7","QP-C","UQBP","UQCR6"],"Ensembl":"ENSG00000156467","Gene description":"Ubiquinol-cytochrome c reductase binding protein","Uniprot":["P14927"],"Chromosome":"8","Position":"96222947-96235546","Protein class":["Disease related genes","Human disease related genes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"1224.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"2003.4","Esophageal suprabasal cells":"1889.4","Kupffer cells":"2063.1","Parietal cells":"4364.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"4364.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"11000","Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":35,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA043060":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.00e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.28e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-6"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"}},{"Gene":"UQCRC1","Gene synonym":["D3S3191","QCR1","UQCR1"],"Ensembl":"ENSG00000010256","Gene description":"Ubiquinol-cytochrome c reductase core protein 1","Uniprot":["P31930"],"Chromosome":"3","Position":"48599002-48610976","Protein class":["Disease related genes","Enzymes","Essential proteins","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Neuropathy","Parkinsonism"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"604.8","skeletal muscle":"718.0","tongue":"825.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"545.6","Enterocytes":"496.5","Esophageal basal cells":"469.2","Late spermatids":"538.3","Parietal cells":"601.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Gastric glandular cells":"601.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"1049604990.3"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"1665184379.2","skeletal muscle":"498598980.4"},"Antibody":["HPA002815","HPA003525","CAB033782"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"180000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":56,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB033782":null,"HPA002815":null,"HPA003525":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.66e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.18e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.09e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-1"}},{"Gene":"UQCRFS1","Gene synonym":["RIP1","RIS1","RISP","UQCR5"],"Ensembl":"ENSG00000169021","Gene description":"Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1","Uniprot":["P47985"],"Chromosome":"19","Position":"29205320-29213151","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Electron transport","Respiratory chain","Transport"],"Molecular function":["Translocase"],"Disease involvement":["Disease variant","Primary mitochondrial disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"216.9","tongue":"267.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"1098.4","Late primary spermatocytes":"467.0","Parietal cells":"641.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"1098.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Cardiomyocytes":"1216081002.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"200544840.8","heart muscle":"596863347.1","skeletal muscle":"175950062.1"},"Antibody":["HPA041863","HPA050339"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"25000","Blood expression cluster":"Cluster 26: Monocytes - Plasma membrane proteins","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":58,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA041863":null,"HPA050339":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.67e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.97e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.55e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.51e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"}},{"Gene":"URAD","Gene synonym":["PRHOXNB"],"Ensembl":"ENSG00000183463","Gene description":"Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase","Uniprot":["A6NGE7"],"Chromosome":"13","Position":"27977717-27988693","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Purine metabolism"],"Molecular function":["Decarboxylase","Lyase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"intestine":"22.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"58.5","Enteric stem cells":"55.9","Enteric transient amplifying cells":"69.7","Enterocytes":"166.0","Goblet cells":"101.7","Neuroendocrine cells":"23.5","Paneth cells":"46.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"166.0","Goblet cells":"101.7","Proliferating cells":"69.7","Secretory gland support":"46.4","Stem cells":"55.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"7","RNA cancer specific pTPM":{"Colon Adenocarcinoma (TCGA)":"7.5","Rectum Adenocarcinoma (TCGA)":"2.9"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":"4","RNA brain regional specific nTPM":{"cerebellum":"1.5"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"8","RNA cell line specific nTPM":{"colorectal cancer":"2.9","liver cancer":"1.3"},"RNA tissue cell type enrichment":["Colon - Colon enterocytes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebral cortex":"6.8"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA038972"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 1: Enterocytes - Absorption and Digestion","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038972":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"USH2A","Gene synonym":["RP39","USH2"],"Ensembl":"ENSG00000042781","Gene description":"Usherin","Uniprot":["O75445"],"Chromosome":"1","Position":"215622891-216423448","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Hearing","Sensory transduction","Vision"],"Molecular function":null,"Disease involvement":["Deafness","Disease variant","Retinitis pigmentosa","Usher syndrome"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"21","RNA tissue specific nTPM":{"liver":"6.5","retina":"17.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Cone photoreceptor cells":"1146.8","Rod photoreceptor cells":"1572.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Neuronal cells":"1572.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Acrosome","Equatorial segment","Mid piece","Principal piece"],"Subcellular additional location":["End piece"],"Antibody RRID":{"HPA045176":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"USP1","Gene synonym":[],"Ensembl":"ENSG00000162607","Gene description":"Ubiquitin specific peptidase 1","Uniprot":["O94782"],"Chromosome":"1","Position":"62436297-62451804","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"211.5","Early primary spermatocytes":"257.7","Late primary spermatocytes":"352.0","Monocyte progenitors":"178.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"352.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":40,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA028387":null,"HPA028440":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.98e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.42e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.78e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"USP15","Gene synonym":["KIAA0529","UNPH4"],"Ensembl":"ENSG00000135655","Gene description":"Ubiquitin specific peptidase 15","Uniprot":["Q9Y4E8"],"Chromosome":"12","Position":"62260338-62417431","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"166.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"1325.1","Neutrophils":"4247.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"4247.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"300.7"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"granulocytes":"300.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006237","HPA006428","HPA071014"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"320000","Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 5: Non-specific - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":103,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Nuclear bodies"],"Antibody RRID":{"HPA006237":null,"HPA006428":null,"HPA071014":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"USP16","Gene synonym":["Ubp-M"],"Ensembl":"ENSG00000156256","Gene description":"Ubiquitin specific peptidase 16","Uniprot":["Q9Y5T5"],"Chromosome":"21","Position":"29024629-29054488","Protein class":["Disease related genes","Enzymes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Activator","Chromatin regulator","Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"549.6","Late primary spermatocytes":"371.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"549.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"1901753.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"743905.8","Stomach":"1658328.1"},"Antibody":["HPA021140"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":13,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021140":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.04e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"}},{"Gene":"USP2","Gene synonym":["UBP41"],"Ensembl":"ENSG00000036672","Gene description":"Ubiquitin specific peptidase 2","Uniprot":["O75604"],"Chromosome":"11","Position":"119355215-119381711","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Biological rhythms","Cell cycle","Myogenesis","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"157.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"576.2","Late spermatids":"1912.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1912.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"14.9"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Skin - Keratinocyte (granular)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"1368695.9","Skeletal myofibers":"1022565.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006777","HPA007222"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":120,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA006777":null,"HPA007222":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.68e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.13e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"}},{"Gene":"USP25","Gene synonym":["USP21"],"Ensembl":"ENSG00000155313","Gene description":"Ubiquitin specific peptidase 25","Uniprot":["Q9UHP3"],"Chromosome":"21","Position":"15729982-15880064","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":["Disease variant","Epilepsy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"112.9"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Pancreatic islets":"1705597.3","Skeletal myofibers":"2595865.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"16238057.9"},"Antibody":["HPA018297","HPA024142"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":45,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA018297":null,"HPA024142":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.45e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.62e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.94e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"USP29","Gene synonym":[],"Ensembl":"ENSG00000131864","Gene description":"Ubiquitin specific peptidase 29","Uniprot":["Q9HBJ7"],"Chromosome":"19","Position":"57119138-57131926","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Immunity","Innate immunity","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"1.5","testis":"4.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"3.1","Early primary spermatocytes":"6.9","Early spermatids":"2.8","Ependymal cells":"1.1","Foveolar cells":"1.2","Gastric chief cells":"1.1","Late primary spermatocytes":"6.2","Undifferentiated spermatogonia":"2.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"1.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA076515"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":6,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA076515":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"}},{"Gene":"USP30","Gene synonym":["FLJ40511","MGC10702"],"Ensembl":"ENSG00000135093","Gene description":"Ubiquitin specific peptidase 30","Uniprot":["Q70CQ3"],"Chromosome":"12","Position":"109023089-109088023","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"90.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"90.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":9,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA016952":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"}},{"Gene":"USP32","Gene synonym":["NY-REN-60","USP10"],"Ensembl":"ENSG00000170832","Gene description":"Ubiquitin specific peptidase 32","Uniprot":["Q8NFA0"],"Chromosome":"17","Position":"60177327-60422470","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"95.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"2854.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Neutrophils":"2854.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"plasmacytoid DC":"59.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"dendritic cells":"59.4","granulocytes":"29.5"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":32,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA044365":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.64e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.93e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.01e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.49e-3"}},{"Gene":"USP37","Gene synonym":["KIAA1594"],"Ensembl":"ENSG00000135913","Gene description":"Ubiquitin specific peptidase 37","Uniprot":["Q86T82"],"Chromosome":"2","Position":"218450251-218568351","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"229.2","Sertoli cells":"277.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"3753797.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"112","Protein tissue specific Intensity":{"cerebral cortex":"11243.8"},"Antibody":["HPA045160"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":22,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA045160":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.09e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.46e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.01e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.16e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.87e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"}},{"Gene":"USP38","Gene synonym":["HP43.8KD","KIAA1891"],"Ensembl":"ENSG00000170185","Gene description":"Ubiquitin specific peptidase 38","Uniprot":["Q8NB14"],"Chromosome":"4","Position":"143184917-143223874","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"16.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial glandular cells":"161.7"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Glomeruli":"106223.2","T-cells":"234688.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"5202823.0"},"Antibody":["HPA036990","HPA047948"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome","Cytosol"],"Antibody RRID":{"HPA036990":null,"HPA047948":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.62e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.43e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":38,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Basal body","Cytosol"],"Antibody RRID":{"HPA018499":null,"HPA074006":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.29e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"}},{"Gene":"USP42","Gene synonym":["FLJ12697"],"Ensembl":"ENSG00000106346","Gene description":"Ubiquitin specific peptidase 42","Uniprot":["Q9H9J4"],"Chromosome":"7","Position":"6104949-6161564","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA006939":null,"HPA064800":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.55e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.09e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.51e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.11e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.49e-2"}},{"Gene":"USP43","Gene synonym":["FLJ30626"],"Ensembl":"ENSG00000154914","Gene description":"Ubiquitin specific peptidase 43","Uniprot":["Q70EL4"],"Chromosome":"17","Position":"9644698-9729687","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"171.4","Endometrial ciliated cells":"138.1","Endometrial glandular cells":"264.4","Endometrial luminal cells":"163.0","Ependymal cells":"185.2","Extravillous trophoblasts":"257.8","Migrating cytotrophoblasts":"130.1","Prostatic glandular cells":"137.1","Syncytiotrophoblasts":"334.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"185.2","Glandular cells":"264.4","Luminal cells":"163.0","Trophoblast cells":"334.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"191.4","oligodendrocyte precursor cell":"111.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Pituitary gland - Corticotropes","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Large ducts":"850644.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"210654.2"},"Antibody":["HPA023389","HPA027762","HPA027763"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":9,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA023389":null,"HPA027762":null,"HPA027763":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.06e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.99e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.97e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"}},{"Gene":"USP44","Gene synonym":["FLJ14528"],"Ensembl":"ENSG00000136014","Gene description":"Ubiquitin specific peptidase 44","Uniprot":["Q9H0E7"],"Chromosome":"12","Position":"95516560-95551476","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Immunity","Innate immunity","Mitosis","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"22.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"480.9","Late primary spermatocytes":"447.8","Late spermatids":"131.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"480.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"upper rhombic lip":"31.3"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"2.2","Testicular Germ Cell Tumor (TCGA)":"6.3"},"RNA brain regional specificity":"Region enriched","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":"5","RNA brain regional specific nTPM":{"cerebellum":"15.1"},"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive CD4 T-cell":"6.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"41","RNA blood lineage specific nTPM":{"B-cells":"4.7","T-cells":"6.1"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"11.3","testis cancer":"12.1"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026543"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":16,"Subcellular main location":["Nucleoli fibrillar center","Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA026543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"}},{"Gene":"USP46","Gene synonym":["FLJ12552"],"Ensembl":"ENSG00000109189","Gene description":"Ubiquitin specific peptidase 46","Uniprot":["P62068"],"Chromosome":"4","Position":"52590960-52659301","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Behavior","Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"288.1","Esophageal apical cells":"148.6","Podocytes":"305.8","Retinal bipolar cells":"141.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"305.8","Spermatogenic cell types":"288.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Pituitary gland - Undifferentiated cells (Pituitary gland)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"932","Protein cell type specific Intensity":{"Astrocytes and Neuropil":"163322.2","Microglia and Neuropil":"61003.8","Neurons":"55410.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"5291","Protein tissue specific Intensity":{"cerebral cortex":"529134.8"},"Antibody":["HPA007288","CAB076369","CAB076370"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli","Nucleoli rim"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 57: Podocytes - Glomerular filtration","Interactions":11,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":null,"Antibody RRID":{"CAB076369":null,"CAB076370":null,"HPA007288":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.19e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.81e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.11e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"}},{"Gene":"USP5","Gene synonym":["IsoT"],"Ensembl":"ENSG00000111667","Gene description":"Ubiquitin specific peptidase 5","Uniprot":["P45974"],"Chromosome":"12","Position":"6852148-6866632","Protein class":["Enzymes","Essential proteins","Metabolic proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"100.4","Syncytiotrophoblasts":"69.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"100.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006756"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1800000","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 1: Neurons - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":38,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA006756":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.65e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.27e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.27e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"}},{"Gene":"USP50","Gene synonym":[],"Ensembl":"ENSG00000170236","Gene description":"Ubiquitin specific peptidase 50","Uniprot":["Q70EL3"],"Chromosome":"15","Position":"50494018-50546708","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Cell cycle"],"Molecular function":["Hydrolase"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"1.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"50.0","Cardiomyocytes":"105.3","Early spermatids":"156.1","Epicardial cells":"195.6","Late primary spermatocytes":"173.4","Late spermatids":"126.2","Oocytes":"156.6","Retinal pigment epithelial cells":"51.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"195.6","Myocytes":"105.3","Oocytes":"156.6","Spermatogenic cell types":"173.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"24.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039470"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039470":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"USP6NL","Gene synonym":["KIAA0019","RN-tre","RNTRE","TRE2NL","USP6NL-IT1"],"Ensembl":"ENSG00000148429","Gene description":"USP6 N-terminal like","Uniprot":["Q92738"],"Chromosome":"10","Position":"11460510-11611666","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["GTPase activation"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"454.8","Esophageal apical cells":"868.9","Microglia":"450.5","Urothelial cells":"366.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"868.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"540.6","endothelial cell":"593.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"4.8","naive B-cell":"4.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"4.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Pituitary gland - Corticotropes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"475688.0","Fallopian tube cells":"709686.6","Glomeruli":"769872.7","Large ducts":"474517.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"3356","Protein tissue specific Intensity":{"fallopian tube":"209141.7","lung":"171398.2","lymphoid tissue":"626393.8"},"Antibody":["HPA039196"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039196":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.04e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.93e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"}},{"Gene":"USP7","Gene synonym":["HAUSP"],"Ensembl":"ENSG00000187555","Gene description":"Ubiquitin specific peptidase 7","Uniprot":["Q93009"],"Chromosome":"16","Position":"8892097-8975328","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Biological rhythms","DNA damage","DNA repair","Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["Developmental protein","Hydrolase","Protease","Thiol protease"],"Disease involvement":["Autism spectrum disorder","Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"332.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"332.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"15000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":286,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies","Cytosol"],"Antibody RRID":{"CAB008108":null,"CAB079904":null,"HPA015641":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.25e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.65e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.31e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 75: Non-specific - Chaperones and protein folding","Interactions":13,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA039342":null,"HPA040172":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"}},{"Gene":"UTP11","Gene synonym":["CGI-94","UTP11L"],"Ensembl":"ENSG00000183520","Gene description":"UTP11 small subunit processome component","Uniprot":["Q9Y3A2"],"Chromosome":"1","Position":"38009258-38024820","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"skeletal muscle":"111.8","tongue":"79.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oocytes":"156.6","Thymic myoid cells":"235.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Stromal cells":"235.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":3,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA027650":null,"HPA045830":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.27e-11"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.78e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"}},{"Gene":"UTP18","Gene synonym":["CGI-48","WDR50"],"Ensembl":"ENSG00000011260","Gene description":"UTP18 small subunit processome component","Uniprot":["Q9Y5J1"],"Chromosome":"17","Position":"51260546-51297936","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["rRNA processing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"207.5","Late primary spermatocytes":"201.7","Late spermatids":"268.5","Oocytes":"184.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"268.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":33,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Nucleoplasm","Nuclear membrane"],"Antibody RRID":{"HPA052378":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.56e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.62e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.15e-7"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.39e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"}},{"Gene":"UTRN","Gene synonym":["DMDL","DRP","DRP1"],"Ensembl":"ENSG00000152818","Gene description":"Utrophin","Uniprot":["P46939"],"Chromosome":"6","Position":"144285335-144853034","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"1287.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"1762.0","pericyte":"1749.0","vascular associated smooth muscle cell":"2274.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"157.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"monocytes":"157.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Lung - Alveolar cells type 1","Skeletal muscle - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB016348","HPA018894"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Plasma membrane","Primary cilium","Basal body"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"16000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 49: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":57,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm","Primary cilium","Basal body"],"Antibody RRID":{"CAB016348":null,"HPA018894":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.36e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.33e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"}},{"Gene":"UTS2B","Gene synonym":["U2B","URP","UTS2D"],"Ensembl":"ENSG00000188958","Gene description":"Urotensin 2B","Uniprot":["Q765I0"],"Chromosome":"3","Position":"191267168-191330526","Protein class":["Predicted secreted proteins"],"Biological process":null,"Molecular function":["Hormone"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"3.2","retina":"5.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"25.7","Cardiomyocytes":"89.7","Epicardial cells":"50.0","Late primary spermatocytes":"23.6","Late spermatids":"15.0","Undifferentiated spermatogonia":"22.8","Vascular endothelial cells":"11.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Adipocytes":"25.7","Barrier epithelial cells":"50.0","Myocytes":"89.7","Spermatogenic cell types":"23.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"2.9","naive B-cell":"1.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"5","RNA blood lineage specific nTPM":{"B-cells":"2.9"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"lymphoma":"9.8","Rhabdoid":"2.9"},"RNA tissue cell type enrichment":["Testis - 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unknown location","Secretome function":"Hormone","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 23: B-cells - Immunoglobulins","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA026992":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.86e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"}},{"Gene":"VAMP8","Gene synonym":["EDB","VAMP-8"],"Ensembl":"ENSG00000118640","Gene description":"Vesicle associated membrane protein 8","Uniprot":["Q9BV40"],"Chromosome":"2","Position":"85561562-85582031","Protein class":["Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Antiviral defense","Autophagy","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"1144.3","Enterocytes":"1101.4","Esophageal apical cells":"2859.8","Esophageal suprabasal cells":"1459.7","Hofbauer cells":"1456.6","Kupffer cells":"1309.8","Syncytiotrophoblasts":"1028.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2859.8","Mononuclear phagocytes":"1456.6","Suprabasal cells":"1459.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"37.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adrenal gland - Macrophages","Breast - Breast glandular cells","Heart muscle - Macrophages","Minor Salivary Gland - Minor salivary glandular cells","Skeletal muscle - Macrophages","Skin - Keratinocyte (other)","Spleen - Macrophages","Stomach - Gastric mucous cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"24107230.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006882","HPA007215","CAB037132","CAB037147"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"79000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":60,"Subcellular main location":["Golgi apparatus","Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB037132":null,"CAB037147":null,"HPA006882":null,"HPA007215":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.92e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.00e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"}},{"Gene":"VARS1","Gene synonym":["VARS","VARS2"],"Ensembl":"ENSG00000204394","Gene description":"Valyl-tRNA synthetase 1","Uniprot":["P26640"],"Chromosome":"6","Position":"31777518-31795752","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"160.7","Late spermatids":"211.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"211.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Macrophages","Pituitary gland - Somatotropes","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA046710"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Cytosol","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"100000","Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 45: Non-specific - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":35,"Subcellular main location":["Endoplasmic reticulum","Cytosol"],"Subcellular additional location":["Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA046710":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.75e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"}},{"Gene":"VASH2","Gene synonym":["FLJ12505"],"Ensembl":"ENSG00000143494","Gene description":"Vasohibin 2","Uniprot":["Q86V25"],"Chromosome":"1","Position":"212950520-212992037","Protein class":["Enzymes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Carboxypeptidase","Hydrolase","Protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"6.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"137.4","Gonadotrophs":"159.7","Late primary spermatocytes":"66.0","Late spermatids":"178.6","pDCs":"65.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"dendritic cells":"65.2","Pituitary endocrine cells":"159.7","Spermatogenic cell types":"178.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"midbrain-derived inhibitory":"91.8"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"11.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Sarcoma":"17.7"},"RNA tissue cell type enrichment":["Pituitary gland - Gonadotropes","Skeletal muscle - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA045820"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 6: Plasmacytoid dendritic cells - Viral sensing & interferon response","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA045820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.33e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"}},{"Gene":"VAV3","Gene synonym":[],"Ensembl":"ENSG00000134215","Gene description":"Vav guanine nucleotide exchange factor 3","Uniprot":["Q9UKW4"],"Chromosome":"1","Position":"107571161-107965180","Protein class":["Predicted intracellular proteins"],"Biological process":["Angiogenesis"],"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"kidney":"78.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"750.2","Distal convoluted tubule cells":"813.3","Hematopoietic stem cells":"1132.5","Lymphatic endothelial cells":"527.1","Neutrophil progenitors":"581.1","Neutrophils":"1072.1","NK-cells":"673.7","Syncytiotrophoblasts":"778.3","Thymocytes":"875.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1072.1","Stem cells":"1132.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"cerebellar inhibitory":"720.8","choroid plexus epithelial cell":"581.8","midbrain-derived inhibitory":"607.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Breast Invasive Carcinoma (TCGA)":"79.0"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Breast - Breast glandular cells","Pituitary gland - Thyrotropes","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"18954711.4","T-cells":"10200063.6"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"3943255.6","lymphoid tissue":"8247713.5"},"Antibody":["CAB002012"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB002012":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.59e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.06e-5"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.93e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"}},{"Gene":"VCPKMT","Gene synonym":["C14orf138","METTL21D","VCP-KMT"],"Ensembl":"ENSG00000100483","Gene description":"Valosin containing protein lysine methyltransferase","Uniprot":["Q9H867"],"Chromosome":"14","Position":"50108632-50116600","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Methyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"96.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"96.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"22307.7","Oocytes":"62895.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"1803783.1","intestine":"478539.8","lung":"698929.5","lymphoid tissue":"1120221.1"},"Antibody":["HPA001146","HPA076561"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA001146":null,"HPA076561":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.40e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"}},{"Gene":"VDAC2","Gene synonym":[],"Ensembl":"ENSG00000165637","Gene description":"Voltage dependent anion channel 2","Uniprot":["P45880"],"Chromosome":"10","Position":"75210154-75231448","Protein class":["Predicted intracellular proteins","Transporters"],"Biological process":["Ion transport","Lipid transport","Transport"],"Molecular function":["Porin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1709.1","Esophageal suprabasal cells":"771.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"1709.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"heart muscle":"638109475.8"},"Antibody":["HPA043475"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"340000","Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 45: Colonocytes & Enterocytes - Gastrointestinal absorption & barrier","Interactions":99,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA043475":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.54e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.42e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.03e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.97e-7"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.73e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"}},{"Gene":"VDAC3","Gene synonym":["HD-VDAC3"],"Ensembl":"ENSG00000078668","Gene description":"Voltage dependent anion channel 3","Uniprot":["Q9Y277"],"Chromosome":"8","Position":"42391624-42405937","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ion transport","Transport"],"Molecular function":["Porin"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"heart muscle":"360.7","skeletal muscle":"857.0","tongue":"879.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"497.5","Megakaryocytes":"463.6","Platelets":"581.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Platelets":"581.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells","Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA026864"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1800000","Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 47: Platelets - Hemostasis","Interactions":50,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA026864":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.87e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.71e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.16e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.85e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"}},{"Gene":"VEPH1","Gene synonym":["FLJ12604","KIAA1692"],"Ensembl":"ENSG00000197415","Gene description":"Ventricular zone expressed PH domain containing 1","Uniprot":["Q14D04"],"Chromosome":"3","Position":"157259742-157533619","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adrenal gland":"19.1","kidney":"25.2","lung":"27.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal cortex cells":"292.0","Alveolar cells type 1":"214.8","Alveolar cells type 2":"383.9","Choroid plexus epithelial cells":"168.2","Early spermatids":"170.8","Late spermatids":"151.4","Neutrophil progenitors":"158.0","Pituitary stem cells":"947.0","Renal collecting duct principal cells":"228.6","Renal connecting tubule cells":"208.9","Retinal pigment epithelial cells":"153.5","Transitional alveolar cells":"236.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"292.0","Alveolar cells":"383.9","Stem cells":"947.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"140.1","ependymal cell":"35.2","lower rhombic lip":"59.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"24.1"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Minor Salivary Gland - Minor salivary gland ductal cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"5714955.5","Collecting ducts":"1944182.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"55006","Protein tissue specific Intensity":{"lung":"5500632.8"},"Antibody":["HPA026645"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 4: Adrenal gland - Steroid metabolism","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 48: Adipocytes & Endothelial cells - Angiogenesis","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":null,"Subcellular main location":["Nucleoplasm","Nucleoli","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA026645":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.04e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.92e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.39e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.19e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.48e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"}},{"Gene":"VKORC1L1","Gene synonym":[],"Ensembl":"ENSG00000196715","Gene description":"Vitamin K epoxide reductase complex subunit 1 like 1","Uniprot":["Q8N0U8"],"Chromosome":"7","Position":"65873074-65959563","Protein class":["Enzymes","FDA approved drug targets","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Oxidoreductase"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"589.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adipocytes":"589.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Liver - Hepatocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"3887588.1"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"1782524.0"},"Antibody":["HPA053954"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":45,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"HPA053954":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.19e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.01e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.34e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.81e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.62e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.64e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.35e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"}},{"Gene":"VPS13A","Gene synonym":["BLTP5A","CHAC","KIAA0986"],"Ensembl":"ENSG00000197969","Gene description":"Vacuolar protein sorting 13 homolog A","Uniprot":["Q96RL7"],"Chromosome":"9","Position":"77177445-77421537","Protein class":["Disease related genes","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Lipid transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Myonuclei":"608.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"608.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"11275881.3"},"Antibody":["HPA021652","HPA021662"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":18,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA021652":null,"HPA021662":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.84e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.84e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.95e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"}},{"Gene":"VPS28","Gene synonym":[],"Ensembl":"ENSG00000160948","Gene description":"VPS28 subunit of ESCRT-I","Uniprot":["Q9UK41"],"Chromosome":"8","Position":"144423601-144428563","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Enterocytes":"253.5","Late primary spermatocytes":"296.5","Platelets":"274.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"22.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"breast cancer":"13.8"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024688","HPA024745"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"4800","Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":49,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA024688":null,"HPA024745":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.17e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.42e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"}},{"Gene":"VPS35L","Gene synonym":["C16orf62","MGC16824"],"Ensembl":"ENSG00000103544","Gene description":"VPS35 endosomal protein sorting factor like","Uniprot":["Q7Z3J2"],"Chromosome":"16","Position":"19555240-19706793","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Oocytes":"594.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"594.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Breast - Fibroblasts","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Proximal tubules":"43765691.1"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042969","HPA053547"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 32: Endothelial cells - Angiogenesis & vascular immunity","Interactions":44,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA042969":null,"HPA053547":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.59e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.17e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.53e-4"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"}},{"Gene":"VPS37A","Gene synonym":["FLJ32642","HCRP1","PQBP2","SPG53"],"Ensembl":"ENSG00000155975","Gene description":"VPS37A subunit of ESCRT-I","Uniprot":["Q8NEZ2"],"Chromosome":"8","Position":"17246931-17302427","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":["Disease variant","Hereditary spastic paraplegia","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA024705","HPA024781"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles","Centrosome","Cytosol","Acrosome","Equatorial segment","Perinuclear theca","Flagellar centriole","Mid piece","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":32,"Subcellular main location":["Vesicles","Centrosome","Acrosome","Flagellar centriole"],"Subcellular additional location":["Nucleoplasm","Cytosol","Equatorial segment","Perinuclear theca","Mid piece","Principal piece","End piece"],"Antibody RRID":{"HPA024705":null,"HPA024781":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.58e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.52e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.10e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-2"}},{"Gene":"VRK2","Gene synonym":[],"Ensembl":"ENSG00000028116","Gene description":"VRK serine\/threonine kinase 2","Uniprot":["Q86Y07"],"Chromosome":"2","Position":"57907629-58159920","Protein class":["Enzymes","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Host-virus interaction"],"Molecular function":["Kinase","Serine\/threonine-protein kinase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"578.1","Oligodendrocytes":"494.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"494.8","Myocytes":"578.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"659.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"332699.7"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"694284.8","lymphoid tissue":"239053.4"},"Antibody":["CAB046459","HPA047503"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 80: Oligodendrocytes - Myelination","Interactions":37,"Subcellular main location":["Endoplasmic reticulum"],"Subcellular additional location":null,"Antibody RRID":{"CAB046459":null,"HPA047503":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.39e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.04e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.71e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.83e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.18e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.05e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"}},{"Gene":"VRK3","Gene synonym":[],"Ensembl":"ENSG00000105053","Gene description":"VRK serine\/threonine kinase 3","Uniprot":["Q8IV63"],"Chromosome":"19","Position":"49976468-50025946","Protein class":["Enzymes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"128.9"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"2917.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"27","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"2917.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"131497.6","lymphoid tissue":"185400.6"},"Antibody":["HPA056489"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":12,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA056489":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 34: Testis cancer - Unknown function","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA001460":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":20,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA003436":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"VTI1B","Gene synonym":["VTI2"],"Ensembl":"ENSG00000100568","Gene description":"Vesicle transport through interaction with t-SNAREs 1B","Uniprot":["Q9UEU0"],"Chromosome":"14","Position":"67647085-67674820","Protein class":["Essential proteins","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"419.3","Late spermatids":"730.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"419.3","Spermatogenic cell types":"730.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":54,"Subcellular main location":["Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA044121":null,"HPA048150":null,"HPA060118":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"VWA2","Gene synonym":["AMACO","CCSP-2","FLJ16213","FLJ45857","NET42"],"Ensembl":"ENSG00000165816","Gene description":"Von Willebrand factor A domain containing 2","Uniprot":["Q5GFL6"],"Chromosome":"10","Position":"114239254-114294489","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"stomach 1":"8.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"32.9","Epididymal basal cells":"51.1","Epididymal efferent duct absorptive cells":"35.4","Epididymal efferent duct ciliated cells":"96.5","Fallopian tube ciliated cells":"33.7","Gastric chief cells":"53.5","Late spermatids":"43.1","Medullary thymic epithelial cells":"45.6","Mucous neck cells":"73.6","Respiratory basal cells":"36.5","Respiratory ciliated cells":"31.4","Respiratory deuterosomal cells":"41.5","Respiratory secretory cells":"36.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"51.1","Ciliated cells":"96.5","Gastric glandular cells":"73.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"7","RNA single nuclei brain specific nCPM":{"deep-layer corticothalamic and 6b":"32.0","deep-layer near-projecting":"32.3","endothelial cell":"105.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"colorectal cancer":"10.1","Gastric cancer":"6.4"},"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Colon - Enteric glia cells","Lung - Alveolar cells type 2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"23329","Protein cell type specific Intensity":{"Alveolar cell types":"1405658.5","Collecting ducts":"2679108.5","Distal tubules":"1392293.1","Fallopian tube cells":"3854429.2"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"15374","Protein tissue specific Intensity":{"fallopian tube":"1674726.3","Stomach":"1400047.3"},"Antibody":["HPA037847"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to extracellular matrix","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 32: Non-specific - Cell proliferation","Single cell expression cluster":"Cluster 104: Brain endothelial cells - Blood brain barrier","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA037847":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"}},{"Gene":"VWA3A","Gene synonym":["FLJ40941","FLJ46765"],"Ensembl":"ENSG00000175267","Gene description":"Von Willebrand factor A domain containing 3A","Uniprot":["A6NCI4"],"Chromosome":"16","Position":"22092538-22156964","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"53.8","fallopian tube":"30.8","pituitary gland":"16.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"13","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"300.3","Ependymal cells":"865.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"19","RNA single cell type group specific nCPM":{"Ciliated cells":"865.4"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"911.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"6.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Bile duct cancer":"2.5"},"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Fallopian tube cells":"5142397.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3351","Protein tissue specific Intensity":{"fallopian tube":"335067.4"},"Antibody":["HPA041696","HPA042044"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in other tissues","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA041696":null,"HPA042044":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.89e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.23e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.13e-2"}},{"Gene":"VWA3B","Gene synonym":["DKFZp686F2227","MGC26733"],"Ensembl":"ENSG00000168658","Gene description":"Von Willebrand factor A domain containing 3B","Uniprot":["Q502W6"],"Chromosome":"2","Position":"98087116-98313299","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"choroid plexus":"8.8","fallopian tube":"20.9","testis":"28.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"596.2","Endometrial ciliated cells":"181.6","Ependymal cells":"361.7","Fallopian tube ciliated cells":"253.7","Late primary spermatocytes":"230.0","Late spermatids":"1801.3","Respiratory ciliated cells":"643.0"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"53","RNA single cell type group specific nCPM":{"Ciliated cells":"643.0","Spermatogenic cell types":"1801.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"412.1"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Lung Adenocarcinoma (TCGA)":"1.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Lung - Respiratory ciliated cells","Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"4","RNA mouse brain regional specific nTPM":{"hippocampal formation":"7.1"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"42187","Protein cell type specific Intensity":{"Fallopian tube cells":"4218714.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"4289","Protein tissue specific Intensity":{"fallopian tube":"428864.6"},"Antibody":["HPA036700","HPA036701"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA036700":null,"HPA036701":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.28e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-1"}},{"Gene":"VWA5B1","Gene synonym":["FLJ32784"],"Ensembl":"ENSG00000158816","Gene description":"Von Willebrand factor A domain containing 5B1","Uniprot":["Q5TIE3"],"Chromosome":"1","Position":"20290875-20359518","Protein class":["Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"13.2","pituitary gland":"11.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"262.6","Ependymal cells":"223.0","Epididymal clear cells":"281.7","Gonadotrophs":"61.0","Papillary tip epithelial cells":"63.7","Renal collecting duct intercalated cells":"189.2","Renal collecting duct principal cells":"52.7","Somatotrophs":"295.3","Thyrotrophs":"50.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"262.6","Ductal cells":"189.2","Pituitary endocrine cells":"295.3","Reproductive supporting cells":"281.7"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"13","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"173.2","ependymal cell":"221.9"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"2.4"},"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"choroid plexus":"47.4"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal medulla cells","Kidney - Intercalated cells","Lung - Fibroblasts_1","Pituitary gland - Somatotropes","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"liver":"1625276.4"},"Antibody":["HPA027496","HPA028405","HPA064829"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Mitochondria","Cytosol"],"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 11: Neuronal - Sensory perception","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA027496":null,"HPA028405":null,"HPA064829":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"VWA8","Gene synonym":["KIAA0564","P7BP2"],"Ensembl":"ENSG00000102763","Gene description":"Von Willebrand factor A domain containing 8","Uniprot":["A3KMH1"],"Chromosome":"13","Position":"41566835-41961120","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Retinitis pigmentosa"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"761.2","Myonuclei":"1172.2","Rod photoreceptor cells":"867.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"1172.2","Neuronal cells":"867.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":20,"Subcellular main location":["Vesicles","Lipid droplets"],"Subcellular additional location":null,"Antibody RRID":{"HPA039075":null,"HPA045478":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.84e-11"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.58e-4"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"}},{"Gene":"WARS1","Gene synonym":["IFI53","IFP53","WARS"],"Ensembl":"ENSG00000140105","Gene description":"Tryptophanyl-tRNA synthetase 1","Uniprot":["P23381"],"Chromosome":"14","Position":"100333790-100376805","Protein class":["Disease related genes","Enzymes","Essential proteins","Human disease related genes","Metabolic proteins","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Angiogenesis","Protein biosynthesis"],"Molecular function":["Aminoacyl-tRNA synthetase","Ligase"],"Disease involvement":["Intellectual disability","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"304.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial luminal cells":"168.6","Late primary spermatocytes":"173.1","Late spermatids":"168.6","monocytes":"301.0","Pituicytes\/FSCs":"166.5","Schwann cells":"282.7","Vascular endothelial cells":"232.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"282.7","Mononuclear phagocytes":"301.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"1347.2","non-classical monocyte":"1617.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005573","HPA018944"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"21000000","Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":9,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA005573":null,"HPA018944":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.42e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.00e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"}},{"Gene":"WASF1","Gene synonym":["KIAA0269","SCAR1","WAVE","WAVE1"],"Ensembl":"ENSG00000112290","Gene description":"WASP family member 1","Uniprot":["Q92558"],"Chromosome":"6","Position":"110099819-110180004","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":["Disease variant","Epilepsy","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"99.1","testis":"73.4"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Late spermatids":"871.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"871.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"8","RNA blood cell specific nTPM":{"memory B-cell":"3.3","naive B-cell":"4.2","plasmacytoid DC":"8.4"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"B-cells":"4.2","dendritic cells":"8.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"20900616.8","Microglia and Neuropil":"30353685.2","Neurons":"25180512.4"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"46473917.5"},"Antibody":["HPA004105","CAB022161"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":"Supported","Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":64,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB022161":null,"HPA004105":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.24e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.08e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.50e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - 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Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"kidney":"5283086.2"},"Antibody":["HPA038339"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 57: Stomach & Colon cancer - Digestion","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":107,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA038339":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.32e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-3"}},{"Gene":"WBP11","Gene synonym":["BUG13","NPWBP","PPP1R165","SIPP1"],"Ensembl":"ENSG00000084463","Gene description":"WW domain binding protein 11","Uniprot":["Q9Y2W2"],"Chromosome":"12","Position":"14784582-14803486","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing","rRNA processing"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"278.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"278.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039710","HPA040037","HPA046403","HPA049126"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Vesicles","Cytosol","Acrosome","Principal piece","End piece"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":45,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol","Acrosome","Principal piece","End piece"],"Antibody RRID":{"HPA039710":null,"HPA040037":null,"HPA046403":null,"HPA049126":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.39e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.58e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.21e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"}},{"Gene":"WDFY4","Gene synonym":["C10orf64","Em:AC060234.3","FLJ45748","KIAA1607"],"Ensembl":"ENSG00000128815","Gene description":"WDFY family member 4","Uniprot":["Q6ZS81"],"Chromosome":"10","Position":"48684873-48982956","Protein class":["Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Autophagy"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"11.0","lymphoid tissue":"26.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"336.3","cDC":"683.0","Early spermatids":"128.7","Macrophages":"129.5","Microglia":"419.1","Monocyte progenitors":"90.6","Neutrophil progenitors":"84.6","Neutrophils":"133.0","pDCs":"362.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"B-cells":"336.3","dendritic cells":"683.0","Glial cells":"419.1"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"546.4","pericyte":"215.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"memory B-cell":"14.2","myeloid DC":"11.3","naive B-cell":"20.9","neutrophil":"9.8","plasmacytoid DC":"32.1"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"7","RNA blood lineage specific nTPM":{"B-cells":"20.9","dendritic cells":"32.1","granulocytes":"9.8"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Leukemia":"13.8","lymphoma":"35.4"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Macrophages","Adrenal gland - Macrophages","Lung - Macrophages","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"B-cells":"49395095.3","Macrophages":"17084045.4","T-cells":"26225715.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"7310947.1"},"Antibody":["HPA040634"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 18: Lymphoid tissue - Immune response","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 82: Dendritic cells - Antigen presentation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040634":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.31e-5"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-1"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.79e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.86e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.74e-2"}},{"Gene":"WDR20","Gene synonym":["Bun107","DMR","FLJ33659","MGC33177"],"Ensembl":"ENSG00000140153","Gene description":"WD repeat domain 20","Uniprot":["Q8TBZ3"],"Chromosome":"14","Position":"102139503-102224847","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"370.8","Late spermatids":"367.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"370.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"712052.1","Large ducts":"589555.0","Microglia and Neuropil":"599034.5","Neurons":"622322.6"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"1017299.6"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.54e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.69e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.26e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"}},{"Gene":"WDR24","Gene synonym":["C16orf21","DKFZp434F054","JFP7"],"Ensembl":"ENSG00000127580","Gene description":"WD repeat domain 24","Uniprot":["Q96S15"],"Chromosome":"16","Position":"684622-690444","Protein class":["Predicted intracellular proteins"],"Biological process":["Autophagy","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Gastric progenitor cells":"37.2","Late primary spermatocytes":"30.5","Late spermatids":"76.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Proliferating cells":"37.2","Spermatogenic cell types":"76.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"2598101.5","lymphoid tissue":"1953796.1"},"Antibody":["HPA039506"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":25,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039506":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.90e-2"}},{"Gene":"WDR26","Gene synonym":["FLJ21016","GID7"],"Ensembl":"ENSG00000162923","Gene description":"WD repeat domain 26","Uniprot":["Q9H7D7"],"Chromosome":"1","Position":"224385146-224437033","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"880.7","Neutrophils":"1159.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"880.7","Neutrophils":"1159.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA028538","HPA028539","HPA061094"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":58,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA028538":null,"HPA028539":null,"HPA061094":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.35e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"}},{"Gene":"WDR31","Gene synonym":["FLJ35921"],"Ensembl":"ENSG00000148225","Gene description":"WD repeat domain 31","Uniprot":["Q8NA23"],"Chromosome":"9","Position":"113313222-113340298","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"parathyroid gland":"10.4","retina":"16.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"76.6","Early primary spermatocytes":"67.1","Respiratory ciliated cells":"67.7","Rod photoreceptor cells":"118.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"67.7","Neuronal cells":"118.7","Spermatogenic cell types":"67.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Heart muscle - Cardiomyocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019340","HPA019347"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 42: Choroid plexus - Mitochondria","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 79: Photoreceptor cells - Phototransduction","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA019340":null,"HPA019347":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.81e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.28e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.14e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.22e-4"}},{"Gene":"WDR37","Gene synonym":["KIAA0982"],"Ensembl":"ENSG00000047056","Gene description":"WD repeat domain 37","Uniprot":["Q9Y2I8"],"Chromosome":"10","Position":"1049538-1160991","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"373.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"373.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 15: NK-cells - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":11,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA037376":null,"HPA037565":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"8100","Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 7: Non-specific - Ribosome","Cell line expression cluster":"Cluster 26: Non-specific - Mitochondria & RNA binding","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":28,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044733":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.86e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.16e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.25e-5"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.11e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"}},{"Gene":"WDR48","Gene synonym":["Bun62","KIAA1449","P80","SPG60"],"Ensembl":"ENSG00000114742","Gene description":"WD repeat domain 48","Uniprot":["Q8TAF3"],"Chromosome":"3","Position":"39052013-39096671","Protein class":["Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair","Host-virus interaction","Ubl conjugation pathway"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":38,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA038421":null,"HPA058015":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.42e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.36e-5"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"}},{"Gene":"WDR49","Gene synonym":["FLJ33620"],"Ensembl":"ENSG00000174776","Gene description":"WD repeat domain 49","Uniprot":["Q8IV35"],"Chromosome":"3","Position":"167478684-167653983","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"8.8","fallopian tube":"8.5","intestine":"4.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"304.6","Bergmann glia":"618.4","Choroid plexus epithelial cells":"747.4","Endometrial ciliated cells":"463.8","Ependymal cells":"1533.8","Epididymal efferent duct ciliated cells":"226.6","Fallopian tube ciliated cells":"355.0","Podocytes":"405.5","Respiratory ciliated cells":"1021.4","Respiratory deuterosomal cells":"269.5"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Ciliated cells":"1533.8","Glial cells":"618.4","Renal nephron cells":"405.5"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"48","RNA single nuclei brain specific nCPM":{"astrocyte":"615.9","Bergmann glia":"657.4","choroid plexus epithelial cell":"560.5","ependymal cell":"1727.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"classical monocyte":"2.7","myeloid DC":"2.2","plasmacytoid DC":"2.9"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"24","RNA blood lineage specific nTPM":{"dendritic cells":"2.9","monocytes":"2.7"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"Leukemia":"2.1"},"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":1,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Mitotic spindle","Primary cilium","Primary cilium tip","Primary cilium transition zone","Basal body","Cytosol"],"Antibody RRID":{"HPA036225":null,"HPA036226":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Golgi apparatus","Vesicles","Acrosome"],"Subcellular additional location":["Nucleoli","Primary cilium tip","Centriolar satellite","Cytosol","Flagellar centriole","Mid piece","Principal piece"],"Antibody RRID":{"HPA043257":null,"HPA053558":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.27e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-2"},"Cancer prognostics - 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Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 62: Skeletal muscle - Muscle contraction","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":49,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Centriolar satellite"],"Antibody RRID":{"HPA043255":null,"HPA043639":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.43e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.80e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.94e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"}},{"Gene":"WDR64","Gene synonym":["FLJ32978"],"Ensembl":"ENSG00000162843","Gene description":"WD repeat domain 64","Uniprot":["B1ANS9"],"Chromosome":"1","Position":"241652278-241802777","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Early spermatids":"349.0","Late spermatids":"240.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"349.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA046186":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"WDR70","Gene synonym":["FLJ10233"],"Ensembl":"ENSG00000082068","Gene description":"WD repeat domain 70","Uniprot":["Q9NW82"],"Chromosome":"5","Position":"37379285-37753435","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 44: Plasmacytoid DCs - Plasma membrane proteins","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":90,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Centriolar satellite","Basal body","Cytosol"],"Antibody RRID":{"HPA042629":null,"HPA042838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"WDR88","Gene synonym":["PQWD"],"Ensembl":"ENSG00000166359","Gene description":"WD repeat domain 88","Uniprot":["Q6ZMY6"],"Chromosome":"19","Position":"33132090-33175799","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"8.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"31.6","Cone photoreceptor cells":"20.7","Early spermatids":"27.1","Late primary spermatocytes":"64.3","Late spermatids":"20.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"31.6","Spermatogenic cell types":"64.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA041916":null,"HPA050336":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"WDR93","Gene synonym":["C1d-87","CFAP297","FAP297"],"Ensembl":"ENSG00000140527","Gene description":"WD repeat domain 93","Uniprot":["Q6P2C0"],"Chromosome":"15","Position":"89690811-89743638","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"choroid plexus":"6.6","fallopian tube":"8.4","testis":"10.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"101.2","Choroid plexus epithelial cells":"51.1","Early spermatids":"103.8","Endometrial ciliated cells":"61.3","Ependymal cells":"183.3","Epididymal efferent duct ciliated cells":"63.0","Fallopian tube ciliated cells":"96.2","Late primary spermatocytes":"137.0","Late spermatids":"70.3","Respiratory ciliated cells":"141.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Adipocytes":"101.2","Ciliated cells":"183.3","Spermatogenic cell types":"137.0"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"11","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"54.0","ependymal cell":"191.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA046196":null,"HPA048112":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.47e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"WDR97","Gene synonym":["KIAA1875"],"Ensembl":"ENSG00000179698","Gene description":"WD repeat domain 97","Uniprot":["A6NE52"],"Chromosome":"8","Position":"144107726-144118328","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"1.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Brain excitatory neurons":"10.5","Brain inhibitory neurons":"9.3","Choroid plexus epithelial cells":"11.0","Cone photoreceptor cells":"6.2","Late primary spermatocytes":"7.1","Paneth cells":"11.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"11.0","Neuronal cells":"10.5","Secretory gland support":"11.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059409":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"WDTC1","Gene synonym":["ADP","DCAF9","KIAA1037"],"Ensembl":"ENSG00000142784","Gene description":"WD and tetratricopeptide repeats 1","Uniprot":["Q8N5D0"],"Chromosome":"1","Position":"27234632-27308636","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"176.0","Neutrophils":"166.9","Rod photoreceptor cells":"240.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"240.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":16,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA028177":null,"HPA028180":null,"HPA028182":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.18e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.28e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.48e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.33e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"}},{"Gene":"WEE1","Gene synonym":["WEE1A"],"Ensembl":"ENSG00000166483","Gene description":"WEE1 G2 checkpoint kinase","Uniprot":["P30291"],"Chromosome":"11","Position":"9573670-9593457","Protein class":["Cancer-related genes","Enzymes","Essential proteins","Plasma proteins","Predicted intracellular proteins"],"Biological process":["Cell cycle","Cell division","Mitosis"],"Molecular function":["Kinase","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"257.6","Breast secretory cells":"258.2","Endometrial glandular cells":"345.2","Endometrial luminal cells":"264.0","Extravillous trophoblasts":"278.8","Ocular epithelial cells":"344.4","Urothelial cells":"299.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"344.4","Glandular cells":"345.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"18.5","fibroblast":"18.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":41,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"CAB004619":null,"HPA068845":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.67e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 50: Epididymis - Male reproductive secretion","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - 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Minor salivary glandular cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"Enzyme inhibitor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 36: Eosinophils - Protein ubiquitination","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 39: Syncytiotrophoblasts - Placental homeostasis & endocrine signal","Interactions":13,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA019852":null,"HPA021488":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.38e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.96e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.70e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.26e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"}},{"Gene":"WIZ","Gene synonym":["ZNF803"],"Ensembl":"ENSG00000011451","Gene description":"WIZ zinc finger","Uniprot":["O95785"],"Chromosome":"19","Position":"15419978-15449956","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"4609704.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"918408.4","ovary":"433414.6"},"Antibody":["HPA022923","HPA023774"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 74: Non-specific - Signal transduction","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":48,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA022923":null,"HPA023774":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.92e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.16e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.73e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.74e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.51e-2"}},{"Gene":"WNT10A","Gene synonym":[],"Ensembl":"ENSG00000135925","Gene description":"Wnt family member 10A","Uniprot":["Q9GZT5"],"Chromosome":"2","Position":"218880852-218899581","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant","Ectodermal dysplasia","Hypotrichosis","Palmoplantar keratoderma"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"7.9","skin 1":"8.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"27.4","Epididymal basal cells":"17.0","Esophageal basal cells":"25.7","Fallopian secretory cells":"10.8","pDCs":"51.5","Plasma cells":"28.7","Retinal bipolar cells":"11.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Basal cells":"27.4","dendritic cells":"51.5","Plasma cells":"28.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"9.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"41.2"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"plasmacytoid DC":"6.2"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"6.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"38.9"},"RNA tissue cell type enrichment":["Adipose visceral - Mesothelial cells","Stomach - Plasma cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"cerebral cortex":"5.2"},"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"basal ganglia":"3.2"},"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA013898"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to extracellular matrix","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 67: Plasma cells - Plasma cell differentiation","Interactions":21,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA013898":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.99e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.00e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.80e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"}},{"Gene":"WNT2","Gene synonym":["INT1L1","IRP"],"Ensembl":"ENSG00000105989","Gene description":"Wnt family member 2","Uniprot":["P09544"],"Chromosome":"7","Position":"117275451-117323152","Protein class":["Cancer-related genes","Predicted secreted proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"placenta":"37.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"12","RNA single cell type specific nCPM":{"Decidual stromal cells":"124.6","Early spermatids":"58.3","Endometrial stromal cells":"33.5","Fibroblasts":"63.6","Late primary spermatocytes":"36.0","Late spermatids":"38.5","Pericytes":"44.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"15","RNA single cell type group specific nCPM":{"Fibroblasts":"63.6","Mural cells":"44.8","Spermatogenic cell types":"58.3","Stromal cells":"124.6"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"hippocampal CA4":"5.7","thalamic excitatory":"13.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Rhabdoid":"2.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Colon - Fibroblasts","Liver - Sinusoid Endothelial cells","Prostate - Fibroblasts","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"basal ganglia":"12.6"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA020920"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":"Secreted to extracellular matrix","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 43: Placenta - Pregnancy hormone signaling","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":7,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA020920":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"}},{"Gene":"WNT7A","Gene synonym":["Wnt-7a"],"Ensembl":"ENSG00000154764","Gene description":"Wnt family member 7A","Uniprot":["O00755"],"Chromosome":"3","Position":"13816258-13880071","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Wnt signaling pathway"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"3.9","gallbladder":"2.2","placenta":"2.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 1":"44.2","Cytotrophoblasts":"87.9","Early spermatids":"23.0","Endometrial luminal cells":"40.1","Endometrial secretory cells":"22.7","Extravillous trophoblasts":"209.5","Migrating cytotrophoblasts":"76.6","Syncytiotrophoblasts":"218.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Trophoblast cells":"218.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"astrocyte":"18.2","eccentric medium spiny neuron":"19.9","LAMP5-LHX6 and Chandelier":"18.9"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Ovary Serous Cystadenocarcinoma (TCGA)":"17.4","Uterine Corpus Endometrial Carcinoma (TCGA)":"30.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"7","RNA blood cell specific nTPM":{"memory CD4 T-cell":"1.7","naive CD4 T-cell":"1.6"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"18","RNA blood lineage specific nTPM":{"T-cells":"1.7"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"ovarian cancer":"23.8","Uterine cancer":"24.6"},"RNA tissue cell type enrichment":["Lung - Alveolar cells type 1","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA015719","CAB025894"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to extracellular matrix","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 39: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 73: Brain - Neuronal signaling","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":7,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB025894":null,"HPA015719":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038539":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 89: Adipocytes - Lipid metabolism","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036570":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"XIRP2","Gene synonym":["CMYA3"],"Ensembl":"ENSG00000163092","Gene description":"Xin actin binding repeat containing 2","Uniprot":["A4UGR9"],"Chromosome":"2","Position":"166888480-167259753","Protein class":["Cancer-related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Actin-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"180.7","skeletal muscle":"962.9","tongue":"458.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"196.5","Myonuclei":"923.7","Thymic myoid cells":"405.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Myocytes":"923.7","Stromal cells":"405.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"9.0"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":null,"Cell line expression cluster":"Cluster 33: Sarcoma - Muscle contraction","Single cell expression cluster":"Cluster 46: Skeletal myocytes - Muscle structure & formation","Interactions":6,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA034813":null,"HPA074599":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA003379":null,"HPA035081":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 7: Small intestine - Absorption and Digestion","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 66: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":11,"Subcellular main location":["Mitochondria"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA000527":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 27: Non-specific - Mixed function","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":11,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA038246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.67e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.42e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.00e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"}},{"Gene":"XRCC1","Gene synonym":["RCC"],"Ensembl":"ENSG00000073050","Gene description":"X-ray repair cross complementing 1","Uniprot":["P18887"],"Chromosome":"19","Position":"43543311-43580473","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA repair"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pituitary gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 54: Non-specific - Ribosome","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":63,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"CAB005427":null,"HPA006717":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.58e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"}},{"Gene":"XRCC2","Gene synonym":["FANCU"],"Ensembl":"ENSG00000196584","Gene description":"X-ray repair cross complementing 2","Uniprot":["O43543"],"Chromosome":"7","Position":"152644776-152676193","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["DNA damage","DNA recombination","DNA repair"],"Molecular function":["DNA-binding"],"Disease involvement":["Cancer-related genes","Disease variant","Fanconi anemia","Premature ovarian failure"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"5.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"21.5","Early primary spermatocytes":"41.6","Erythrocyte progenitors":"44.1","Extravillous trophoblasts":"31.9","Late primary spermatocytes":"21.9","Megakaryocyte progenitors":"101.9","Megakaryocyte-Erythroid progenitors":"20.9","Migrating cytotrophoblasts":"23.3","Monocyte progenitors":"23.7","Syncytiotrophoblasts":"20.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Erythrocytes":"44.1","Megakaryocytes":"101.9","Spermatogenic cell types":"41.6","Trophoblast cells":"31.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Mitotic cells (Adrenal gland)","Lung - Mitotic cells (Lung)","Spleen - Mitotic cells (Spleen)","Stomach - Mitotic cells (Stomach)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA065153"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 66: Erythroid cells - Erythroid differentiation and maturation","Interactions":13,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA065153":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.41e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.74e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.25e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.94e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.78e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"XRRA1","Gene synonym":["FLJ00225"],"Ensembl":"ENSG00000166435","Gene description":"X-ray radiation resistance associated 1","Uniprot":["Q6P2D8"],"Chromosome":"11","Position":"74807739-74949200","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"500.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"500.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in single","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039263"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA039263":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.35e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.61e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.90e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"}},{"Gene":"XYLT2","Gene synonym":["PXYLT2","XT-II"],"Ensembl":"ENSG00000015532","Gene description":"Xylosyltransferase 2","Uniprot":["Q9H1B5"],"Chromosome":"17","Position":"50346126-50363138","Protein class":["Disease related genes","Enzymes","Human disease related genes","Metabolic proteins","Potential drug targets","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Glycosyltransferase","Transferase"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"stomach 1":"85.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"395.3","Gastric chief cells":"159.4","Late primary spermatocytes":"104.2","Late spermatids":"121.3","Mucous neck cells":"106.2"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Gastric glandular cells":"159.4","Spermatogenic cell types":"395.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Adipose visceral - Adipose progenitor cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"626856.4"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"950000","Blood expression cluster":"Cluster 11: T-cells - Unknown function","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.88e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.89e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-1"}},{"Gene":"YAE1","Gene synonym":["C7orf36","CIAB2","GK003","YAE1D1"],"Ensembl":"ENSG00000241127","Gene description":"YAE1 maturation factor of ABCE1","Uniprot":["Q9NRH1"],"Chromosome":"7","Position":"39566385-39610320","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"108.9","Oocytes":"82.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"108.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1733","Protein cell type specific Intensity":{"Fallopian tube cells":"256144.4","Granulosa cells":"158106.9","Keratinocytes":"105574.4"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA019226","HPA031249"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":16,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA019226":null,"HPA031249":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.52e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.42e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.28e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"YBEY","Gene synonym":["C21orf57"],"Ensembl":"ENSG00000182362","Gene description":"YbeY metalloendoribonuclease","Uniprot":["P58557"],"Chromosome":"21","Position":"46286342-46297751","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Endonuclease","Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"75.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"315.1","Late primary spermatocytes":"725.1","Late spermatids":"354.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"725.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"868","Protein cell type specific Intensity":{"Granulosa cells":"35735.6","Proximal tubules":"137902.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA016593","HPA018162"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 25: Non-specific - Ribosome","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA016593":null,"HPA018162":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.69e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.66e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.16e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"}},{"Gene":"YBX1","Gene synonym":["BP-8","CSDA2","CSDB","DBPB","MDR-NF1","NSEP-1","NSEP1","YB-1","YB1"],"Ensembl":"ENSG00000065978","Gene description":"Y-box binding protein 1","Uniprot":["P67809"],"Chromosome":"1","Position":"42682418-42703805","Protein class":["Cancer-related genes","Essential proteins","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["mRNA processing","mRNA splicing","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Mitogen","Repressor","RNA-binding"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"1910.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"7800.5","Kupffer cells":"2418.8","Late primary spermatocytes":"9300.8","Late spermatids":"3964.9","Megakaryocytes":"2528.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"9300.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Smooth muscle cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"27904805.3"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB005875","HPA040304","HPA057159"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Endoplasmic reticulum","Vesicles","Plasma membrane","Cytosol"],"Secretome location":"Intracellular and membrane","Secretome function":"Transcription","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1200000","Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":222,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Endoplasmic reticulum","Vesicles","Plasma membrane"],"Antibody RRID":{"CAB005875":null,"HPA040304":null,"HPA057159":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.60e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.48e-8"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.44e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.92e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.05e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-3"}},{"Gene":"YBX2","Gene synonym":["Contrin","CSDA3","MSY2"],"Ensembl":"ENSG00000006047","Gene description":"Y-box binding protein 2","Uniprot":["Q9Y2T7"],"Chromosome":"17","Position":"7288263-7294639","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":null,"Molecular function":["DNA-binding","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"87","RNA tissue specific nTPM":{"testis":"493.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"29.7","Early spermatids":"85.1","Late primary spermatocytes":"119.9","Late spermatids":"126.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"32","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"126.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA4":"6.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"breast cancer":"6.3"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Minor Salivary Gland - Minor salivary gland ductal cells","Skin - Eccrine sweat gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"23111612.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB012332","HPA053904","HPA056744"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":11,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB012332":null,"HPA053904":null,"HPA056744":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.54e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.36e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.44e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.29e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.81e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.42e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"}},{"Gene":"YBX3","Gene synonym":["CSDA","CSDA1","dbpA","ZONAB"],"Ensembl":"ENSG00000060138","Gene description":"Y-box binding protein 3","Uniprot":["P16989"],"Chromosome":"12","Position":"10699089-10723323","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"skeletal muscle":"4495.4","tongue":"1528.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"1270.6","Esophageal apical cells":"1633.3","Late primary spermatocytes":"1712.4","Pancreatic acinar cells":"1391.3","Thymic myoid cells":"4539.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Stromal cells":"4539.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"209.6","vascular associated smooth muscle cell":"238.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"naive B-cell":"6.5"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Neutrophils","Heart muscle - Macrophages","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"34074011.6","Oocytes":"47171755.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skeletal muscle":"54511880.2"},"Antibody":["HPA034838"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"190000","Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":30,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA034838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.68e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.77e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.32e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.67e-5"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"}},{"Gene":"YEATS4","Gene synonym":["GAS41","NuBI-1","YAF9"],"Ensembl":"ENSG00000127337","Gene description":"YEATS domain containing 4","Uniprot":["O95619"],"Chromosome":"12","Position":"69359710-69390870","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["Growth regulation","Transcription","Transcription regulation"],"Molecular function":["Chromatin regulator"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"360.6","Late primary spermatocytes":"204.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"360.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Spermatocytes","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"T-cells":"2161339.9"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"966446.8","lung":"392051.1","lymphoid tissue":"1189139.4"},"Antibody":["HPA072532"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":72,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear membrane"],"Antibody RRID":{"HPA072532":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.62e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.75e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.76e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.26e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - 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Minor salivary glandular cells","Pituitary gland - Lactotropes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"252","Protein tissue specific Intensity":{"salivary gland":"25215.8"},"Antibody":["HPA019902"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 8: Non-specific - Secretory pathway","Interactions":26,"Subcellular main location":["Golgi apparatus","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA019902":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.33e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.11e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"}},{"Gene":"YPEL1","Gene synonym":[],"Ensembl":"ENSG00000100027","Gene description":"Yippee like 1","Uniprot":["O60688"],"Chromosome":"22","Position":"21697536-21735794","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"149.8"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"9","RNA single cell type specific nCPM":{"Early spermatids":"645.6","Late primary spermatocytes":"1129.3","Late spermatids":"1955.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1955.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"medium spiny neuron":"152.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"16.1"},"RNA tissue cell type enrichment":["Minor Salivary Gland - Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA030501","HPA045621"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 33: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA030501":null,"HPA045621":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.39e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.03e-4"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.94e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"}},{"Gene":"YPEL5","Gene synonym":["CGI-127"],"Ensembl":"ENSG00000119801","Gene description":"Yippee like 5","Uniprot":["P62699"],"Chromosome":"2","Position":"30146941-30160533","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"bone marrow":"413.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"651.5","Late spermatids":"930.8","Neutrophil progenitors":"549.6","Neutrophils":"929.7","Syncytiotrophoblasts":"538.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"929.7","Spermatogenic cell types":"930.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 52: Neurons & Synapses - Synaptic function","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":53,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA042809":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.34e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.50e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.67e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"}},{"Gene":"ZAN","Gene synonym":[],"Ensembl":"ENSG00000146839","Gene description":"Zonadhesin","Uniprot":["Q9Y493"],"Chromosome":"7","Position":"100733595-100797797","Protein class":["Essential proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"No human protein\/transcript evidence","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cytotrophoblasts":"12.1","Early primary spermatocytes":"15.6","Early spermatids":"17.4","Late primary spermatocytes":"28.3","Late spermatids":"43.5","Retinal ganglion cells":"11.6","Syncytiotrophoblasts":"22.4"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neuronal cells":"11.6","Spermatogenic cell types":"43.5","Trophoblast cells":"22.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"10","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"1.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZAR1","Gene synonym":["Z3CXXC6"],"Ensembl":"ENSG00000182223","Gene description":"Zygote arrest 1","Uniprot":["Q86SH2"],"Chromosome":"4","Position":"48490252-48494389","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Oogenesis"],"Molecular function":["Developmental protein","RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"1.3"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"10","RNA single cell type specific nCPM":{"Oocytes":"115.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Oocytes":"115.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"CGE interneuron":"1.6"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Region enhanced","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":{"midbrain":"7.0"},"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"9","RNA cell line specific nTPM":{"Neuroblastoma":"3.4"},"RNA tissue cell type enrichment":["Pituitary gland - Thyrotropes","Skin - Hair cortex cells","Skin - Inner root sheath cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Region enhanced","RNA pig brain regional distribution":"Detected in some","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":{"midbrain":"2.7"},"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"473278","Protein cell type specific Intensity":{"Oocytes":"47327764.3"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"12541","Protein tissue specific Intensity":{"liver":"1254133.1"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 41: Oocytes - Oogenesis","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZBBX","Gene synonym":["FLJ23049"],"Ensembl":"ENSG00000169064","Gene description":"Zinc finger B-box domain containing","Uniprot":["A8MT70"],"Chromosome":"3","Position":"167239843-167407874","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"choroid plexus":"12.9","fallopian tube":"21.8","testis":"33.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"392.5","Early spermatids":"431.4","Endometrial ciliated cells":"278.0","Ependymal cells":"1090.3","Epididymal efferent duct ciliated cells":"322.8","Fallopian tube ciliated cells":"395.6","Late primary spermatocytes":"315.2","Late spermatids":"356.1","Respiratory ciliated cells":"716.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"17","RNA single cell type group specific nCPM":{"Ciliated cells":"1090.3","Spermatogenic cell types":"431.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"344.1","ependymal cell":"1171.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in single","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"1.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Bile duct cancer":"1.3","testis cancer":"1.2"},"RNA tissue cell type enrichment":["Lung - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA036327":null,"HPA036328":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Golgi apparatus"],"Antibody RRID":{"HPA007246":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"ZBTB17","Gene synonym":["MIZ1","pHZ-67","ZNF151","ZNF60"],"Ensembl":"ENSG00000116809","Gene description":"Zinc finger and BTB domain containing 17","Uniprot":["Q13105"],"Chromosome":"1","Position":"15941869-15976132","Protein class":["Essential proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Epicardial cells":"79.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":23,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA005789":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.96e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.71e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - 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Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"1394301.8"},"Antibody":["HPA015551","HPA016815"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":null,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA015551":null,"HPA016815":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.83e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":10,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA076730":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZBTB42","Gene synonym":["ZNF925"],"Ensembl":"ENSG00000179627","Gene description":"Zinc finger and BTB domain containing 42","Uniprot":["B2RXF5"],"Chromosome":"14","Position":"104800596-104804712","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Alveolar cells type 2":"15.2","Fallopian tube ciliated cells":"18.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"endothelial cell":"1.4","ependymal cell":"1.7","leukocyte":"1.5","vascular associated smooth muscle cell":"2.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"10","RNA blood cell specific nTPM":{"eosinophil":"5.4"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"10","RNA blood lineage specific nTPM":{"granulocytes":"5.4"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose visceral - Adipocytes (Visceral)","Breast - Breast glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA066961"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 81: Alveolar cells - Lung function","Interactions":43,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA066961":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.15e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.84e-4"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"}},{"Gene":"ZBTB44","Gene synonym":["BTBD15","HSPC063","ZNF851"],"Ensembl":"ENSG00000196323","Gene description":"Zinc finger and BTB domain containing 44","Uniprot":["Q8NCP5"],"Chromosome":"11","Position":"130226677-130314917","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1053","Protein cell type specific Intensity":{"Neurons":"105267.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA052589"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":7,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA052589":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.25e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.25e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":31,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA030417":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.24e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.85e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-2"}},{"Gene":"ZC2HC1C","Gene synonym":["C14orf140","FAM164C"],"Ensembl":"ENSG00000119703","Gene description":"Zinc finger C2HC-type containing 1C","Uniprot":["Q53FD0"],"Chromosome":"14","Position":"75064109-75119502","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"22.6","testis":"51.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"302.0","Early spermatids":"118.3","Epicardial cells":"161.5","Late primary spermatocytes":"437.9","Late spermatids":"280.2","Myonuclei":"189.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"161.5","Myocytes":"302.0","Spermatogenic cell types":"437.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Heart muscle - Cardiomyocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"3647","Protein tissue specific Intensity":{"salivary gland":"364709.6"},"Antibody":["HPA050928","HPA065062"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":19,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"HPA050928":null,"HPA065062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.35e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.67e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.59e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.06e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.67e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.77e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":115,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA039236":null,"HPA062265":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.09e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.23e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.48e-2"}},{"Gene":"ZC3H11B","Gene synonym":["ZC3HDC11B"],"Ensembl":"ENSG00000215817","Gene description":"Zinc finger CCCH-type containing 11B","Uniprot":["A0A1B0GTU1"],"Chromosome":"1","Position":"219608012-219613105","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"14","RNA tissue specific nTPM":{"testis":"5.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Distal convoluted tubule cells":"9.3","Late primary spermatocytes":"13.2","Loop of henle epithelial cells":"8.7","Papillary tip epithelial cells":"3.8","Podocytes":"6.7","Proximal tubule cells":"14.2","Renal collecting duct intercalated cells":"9.3","Renal collecting duct principal cells":"4.7","Renal connecting tubule cells":"8.8"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ductal cells":"9.3","Renal nephron cells":"14.2","Spermatogenic cell types":"13.2"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"1.7"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"1.4"},"RNA tissue cell type enrichment":["Heart muscle - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 9: Skin cancer - Melanin biosynthesis","Single cell expression cluster":"Cluster 105: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA026439":null,"HPA028490":null,"HPA028526":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZC3H14","Gene synonym":["FLJ11806","NY-REN-37","UKp68"],"Ensembl":"ENSG00000100722","Gene description":"Zinc finger CCCH-type containing 14","Uniprot":["Q6PJT7"],"Chromosome":"14","Position":"88562970-88627596","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant","Intellectual disability"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in all","RNA tissue specificity score":"4","RNA tissue specific nTPM":{"testis":"162.0"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"1426.6","Late primary spermatocytes":"915.7","Late spermatids":"599.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1426.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":8,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Nucleoli","Nucleoli rim"],"Antibody RRID":{"HPA049798":null,"HPA053510":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.07e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.25e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.86e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.63e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"}},{"Gene":"ZC3H3","Gene synonym":["KIAA0150","ZC3HDC3"],"Ensembl":"ENSG00000014164","Gene description":"Zinc finger CCCH-type containing 3","Uniprot":["Q8IXZ2"],"Chromosome":"8","Position":"143437659-143541447","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA transport","Transport"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"95.1","Ocular epithelial cells":"106.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"106.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 68: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":124,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA023658":null,"HPA050577":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.90e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.32e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.42e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 19: Skeletal muscle - Striated muscle contraction","Brain expression cluster":"Cluster 37: Neurons - Mixed function","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":15,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA034803":null,"HPA034804":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.39e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.04e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"}},{"Gene":"ZCCHC13","Gene synonym":["4930513O09RIK","Cnbp2","ZNF9L"],"Ensembl":"ENSG00000187969","Gene description":"Zinc finger CCHC-type containing 13","Uniprot":["Q8WW36"],"Chromosome":"X","Position":"74304180-74305034","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"214","RNA tissue specific nTPM":{"testis":"21.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"7","RNA single cell type specific nCPM":{"Early spermatids":"267.3","Late spermatids":"994.0"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"444","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"994.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 23: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":null,"Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA003382":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZCCHC14","Gene synonym":["BDG29","MGC14139"],"Ensembl":"ENSG00000140948","Gene description":"Zinc finger CCHC-type containing 14","Uniprot":["Q8WYQ9"],"Chromosome":"16","Position":"87406246-87493024","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 12: Endothelial cells - Angiogenesis & vascular homeostasis","Interactions":9,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA014122":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.70e-9"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.70e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.06e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.08e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.66e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-2"}},{"Gene":"ZCCHC2","Gene synonym":["C18orf49","FLJ20222","FLJ20281","KIAA1744"],"Ensembl":"ENSG00000141664","Gene description":"Zinc finger CCHC-type containing 2","Uniprot":["Q9C0B9"],"Chromosome":"18","Position":"62523025-62587709","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"223.4","Salivary acinar cells":"251.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Eccrine sweat gland cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"674","Protein cell type specific Intensity":{"Oocytes":"67362.0"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA040711","HPA040943"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Nucleoli rim","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 45: Liver - Metabolism & Coagulation","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 13: Non-specific - Mixed function","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":1,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Nucleoli rim","Cytosol"],"Antibody RRID":{"HPA040711":null,"HPA040943":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-3"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.50e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.26e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.90e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"}},{"Gene":"ZCCHC8","Gene synonym":["DKFZp434E2220"],"Ensembl":"ENSG00000033030","Gene description":"Zinc finger CCHC-type containing 8","Uniprot":["Q6NZY4"],"Chromosome":"12","Position":"122471599-122501073","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"41.2"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Pancreas - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"5444802.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"pancreas":"13617793.1"},"Antibody":["HPA037483","HPA037484"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 15: Bone marrow - Innate immune response","Brain expression cluster":"Cluster 4: Non-specific - mRNA splicing & Cell cycle","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":65,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA037483":null,"HPA037484":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.21e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"}},{"Gene":"ZCRB1","Gene synonym":["MADP-1","MADP1","RBM36","SNRNP31","ZCCHC19"],"Ensembl":"ENSG00000139168","Gene description":"Zinc finger CCHC-type and RNA binding motif containing 1","Uniprot":["Q8TBF4"],"Chromosome":"12","Position":"42312086-42326257","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":["RNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"332.0","Early spermatids":"816.6","Late primary spermatocytes":"959.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"959.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Neurons":"290294.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"fallopian tube":"23371.7"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":43,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.19e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.09e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.61e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"8.00e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.32e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.31e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"}},{"Gene":"ZCWPW2","Gene synonym":["ZCW2"],"Ensembl":"ENSG00000206559","Gene description":"Zinc finger CW-type and PWWP domain containing 2","Uniprot":["Q504Y3"],"Chromosome":"3","Position":"28348721-28538122","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"9.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"69.6","Bergmann glia":"54.4","Brain excitatory neurons":"47.8","Brain inhibitory neurons":"47.8","Cardiomyocytes":"77.8","Choroid plexus epithelial cells":"59.5","Early spermatids":"45.6","Ependymal cells":"57.0","Epicardial cells":"79.6","Late primary spermatocytes":"134.9","Oligodendrocyte progenitor cells":"50.9","Oligodendrocytes":"40.5","Other brain neurons":"40.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"79.6","Ciliated cells":"59.5","Glial cells":"69.6","Myocytes":"77.8","Neuronal cells":"47.8","Spermatogenic cell types":"134.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skeletal muscle - Skeletal myocytes","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035035","HPA039839"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":2,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA035035":null,"HPA039839":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.04e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-2"}},{"Gene":"ZDHHC1","Gene synonym":["C16orf1","HSU90653","ZNF377"],"Ensembl":"ENSG00000159714","Gene description":"Zinc finger DHHC-type containing 1","Uniprot":["Q8WTX9"],"Chromosome":"16","Position":"67394152-67416833","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"132.9","Endometrial ciliated cells":"107.5","Epididymal efferent duct ciliated cells":"87.3","Fallopian tube ciliated cells":"107.4","Late primary spermatocytes":"168.8","Late spermatids":"305.8","Respiratory ciliated cells":"149.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"6","RNA single cell type group specific nCPM":{"Ciliated cells":"149.7","Spermatogenic cell types":"305.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"64.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"intermediate monocyte":"1.4","non-classical monocyte":"1.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Lung - Respiratory ciliated cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"502","Protein cell type specific Intensity":{"Fallopian tube cells":"50210.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA042531","HPA048659"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 40: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":14,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042531":null,"HPA048659":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.23e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.09e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.23e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.64e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-2"}},{"Gene":"ZDHHC12","Gene synonym":["FLJ14524","ZNF400"],"Ensembl":"ENSG00000160446","Gene description":"Zinc finger DHHC-type palmitoyltransferase 12","Uniprot":["Q96GR4"],"Chromosome":"9","Position":"128720870-128724127","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"151.0","Cytotrophoblasts":"215.2","Enterocytes":"162.6","Esophageal apical cells":"228.5","Esophageal basal cells":"190.2","Esophageal suprabasal cells":"222.8","Extravillous trophoblasts":"286.1","Hofbauer cells":"151.2","Migrating cytotrophoblasts":"187.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"228.5","Trophoblast cells":"286.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"13.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)","Spleen - Neutrophils_2","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059339"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Intermediate filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 60: Stomach - Digestion","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Intermediate filaments"],"Antibody RRID":{"HPA059339":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.94e-4"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.86e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.93e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"}},{"Gene":"ZDHHC13","Gene synonym":["FLJ10852","FLJ10941","HIP14L"],"Ensembl":"ENSG00000177054","Gene description":"Zinc finger DHHC-type palmitoyltransferase 13","Uniprot":["Q8IUH4"],"Chromosome":"11","Position":"19117099-19176422","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"189.3","Esophageal apical cells":"487.7","Neutrophil progenitors":"172.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"487.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Macrophages","Liver - Vascular endothelial cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"1212496.0","fallopian tube":"1287936.1"},"Antibody":["HPA016759","HPA018791"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":21,"Subcellular main location":["Vesicles"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA016759":null,"HPA018791":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.43e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.14e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.30e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.15e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.27e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"}},{"Gene":"ZDHHC2","Gene synonym":["DHHC2","ZNF372"],"Ensembl":"ENSG00000104219","Gene description":"Zinc finger DHHC-type palmitoyltransferase 2","Uniprot":["Q9UIJ5"],"Chromosome":"8","Position":"17156482-17224799","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"retina":"72.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"236.0","Rod photoreceptor cells":"336.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"336.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023331","HPA023334"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA023331":null,"HPA023334":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.66e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.40e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.27e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.93e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.42e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"}},{"Gene":"ZDHHC20","Gene synonym":["DHHC20","FLJ25952"],"Ensembl":"ENSG00000180776","Gene description":"Zinc finger DHHC-type palmitoyltransferase 20","Uniprot":["Q5W0Z9"],"Chromosome":"13","Position":"21348784-21459370","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["Host-virus interaction"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"monocytes":"564.1","Neutrophils":"1413.4","Oligodendrocytes":"445.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"1413.4"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"oligodendrocyte":"724.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Astrocytes and Neuropil":"346957.9","Pancreatic islets":"478089.5"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"691564.4","intestine":"200137.6"},"Antibody":["HPA014483","HPA014702"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":2,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA014483":null,"HPA014702":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.99e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.27e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.90e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.11e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.55e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.17e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.11e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.82e-2"}},{"Gene":"ZDHHC23","Gene synonym":["MGC42530"],"Ensembl":"ENSG00000184307","Gene description":"Zinc finger DHHC-type palmitoyltransferase 23","Uniprot":["Q8IYP9"],"Chromosome":"3","Position":"113947901-113965401","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"10.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"40.1","Epicardial cells":"36.4","Late primary spermatocytes":"40.9","Late spermatids":"60.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"60.6"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"hippocampal CA1-3":"81.2","hippocampal CA4":"80.3"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"17.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1452","Protein cell type specific Intensity":{"Neurons":"145247.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"13822","Protein tissue specific Intensity":{"lung":"1382151.2"},"Antibody":["HPA016808"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 35: Neurons - Synaptic function & neurogenesis","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA016808":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.59e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.30e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.61e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.54e-5"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.43e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"}},{"Gene":"ZDHHC3","Gene synonym":["DHHC3","GODZ","ZNF373"],"Ensembl":"ENSG00000163812","Gene description":"Zinc finger DHHC-type palmitoyltransferase 3","Uniprot":["Q9NYG2"],"Chromosome":"3","Position":"44915257-44976185","Protein class":["Enzymes","Metabolic proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":null,"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"556.9","Late spermatids":"1958.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1958.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Skin - Keratinocyte (other)","Spleen - Endothelial cells","Stomach - Gastric mucous cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Collecting ducts":"567586.6"},"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"14682.3","lymphoid tissue":"44593.3"},"Antibody":["CAB012465","HPA016616"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":3,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"CAB012465":null,"HPA016616":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.76e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.02e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.77e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.24e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.10e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.45e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.55e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - 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Adipocytes (Subcutaneous)","Adrenal gland - Adrenal cortex cells","Liver - Hepatocytes","Testis - Early spermatids","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA032124"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 38: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 41: Monoamines - Neurotransmitter signalling","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA032124":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.18e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.00e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.07e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.40e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.69e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.92e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-1"}},{"Gene":"ZDHHC5","Gene synonym":["DHHC5","KIAA1748","ZNF375"],"Ensembl":"ENSG00000156599","Gene description":"Zinc finger DHHC-type palmitoyltransferase 5","Uniprot":["Q9C0B5"],"Chromosome":"11","Position":"57667747-57701182","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Immunity","Innate immunity","Lipid transport","Transport"],"Molecular function":["Acyltransferase","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"155.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"155.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 100: Stratified epithelial cells - Barrier functions","Interactions":8,"Subcellular main location":["Nucleoplasm","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA014670":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.64e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.76e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.97e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.65e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.06e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.08e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.84e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.02e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-1"}},{"Gene":"ZEB1","Gene synonym":["AREB6","BZP","FECD6","NIL-2-A","PPCD3","TCF8","ZEB","Zfhep","Zfhx1a"],"Ensembl":"ENSG00000148516","Gene description":"Zinc finger E-box binding homeobox 1","Uniprot":["P37275"],"Chromosome":"10","Position":"31318495-31529814","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Neurogenesis","Transcription","Transcription regulation"],"Molecular function":["Activator","DNA-binding","Repressor"],"Disease involvement":["Corneal dystrophy","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial stromal cells":"1976.0","Fibro-adipogenic progenitors":"1444.4","Oligodendrocyte progenitor cells":"1229.1","Thyrotrophs":"714.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Fibro-adipogenic progenitors":"1444.4","Glial cells":"1229.1","Stromal cells":"1976.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"pericyte":"2152.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"36.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Endothelial cells","Liver - Vascular endothelial cells","Minor Salivary Gland - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Capillaries":"278122.2","Oocytes":"803036.1"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"36132.9"},"Antibody":["HPA027524","CAB058686","CAB079943"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 108: Fibroblasts - ECM organization","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"CAB058686":null,"CAB079943":null,"HPA027524":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.30e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.20e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.06e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.41e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"}},{"Gene":"ZER1","Gene synonym":["C9orf60","Hzyg","ZYG","ZYG11BL"],"Ensembl":"ENSG00000160445","Gene description":"Zyg-11 related cell cycle regulator","Uniprot":["Q7Z7L7"],"Chromosome":"9","Position":"128729786-128772414","Protein class":["Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 24: Neurons - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":23,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA048464":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.73e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.24e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.37e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":null,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA057543":null,"HPA074103":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.48e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.38e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.67e-5"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.83e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"}},{"Gene":"ZFAND6","Gene synonym":["AWP1","ZA20D3","ZFAND5B"],"Ensembl":"ENSG00000086666","Gene description":"Zinc finger AN1-type containing 6","Uniprot":["Q6FIF0"],"Chromosome":"15","Position":"80059568-80138393","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Protein transport","Transport"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"841.8","Neutrophils":"917.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA034845":null,"HPA052746":null,"HPA077824":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.66e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 17: Neuroblastoma - Neuronal signaling","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":2,"Subcellular main location":["Nucleoli fibrillar center"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA000720":null,"HPA005146":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.01e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"3300000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 3: Rhabdoid - Membrane components","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":5,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA023837":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 58: Skin - Keratinization","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 50: Renal epithelial cells - Ion transport and pH regulation","Interactions":20,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA035112":null,"HPA058387":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.43e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}},{"Gene":"ZFP91","Gene synonym":["PZF","ZNF757"],"Ensembl":"ENSG00000186660","Gene description":"ZFP91 zinc finger protein, atypical E3 ubiquitin ligase","Uniprot":["Q96JP5"],"Chromosome":"11","Position":"58579063-58621550","Protein class":["Enzymes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"6.6","Endometrial secretory cells":"5.2","Late primary spermatocytes":"7.6","Late spermatids":"12.5","Parietal cells":"5.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"12.5"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":19,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"CAB025417":null,"HPA024037":null,"HPA065325":null,"HPA074591":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.77e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.91e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.52e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.32e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.10e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.81e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"}},{"Gene":"ZFR2","Gene synonym":["KIAA1086"],"Ensembl":"ENSG00000105278","Gene description":"Zinc finger RNA binding protein 2","Uniprot":["Q9UPR6"],"Chromosome":"19","Position":"3804024-3869038","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"7","RNA tissue specific nTPM":{"brain":"15.0","pituitary gland":"27.4","retina":"10.1","testis":"14.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adrenal medulla cells":"85.1","Brain excitatory neurons":"56.4","Brain inhibitory neurons":"73.8","Cone photoreceptor cells":"84.9","Corticotrophs":"86.4","Early primary spermatocytes":"63.9","Lactotrophs":"130.1","Late primary spermatocytes":"53.6","Other brain neurons":"74.1","Retinal amacrine cells":"148.9","Retinal bipolar cells":"104.8","Retinal ganglion cells":"69.5","Retinal horizontal cells":"108.2","Rod photoreceptor cells":"91.7","Somatotrophs":"91.2","Thyrotrophs":"138.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Adrenal endocrine cells":"85.1","Neuronal cells":"148.9","Pituitary endocrine cells":"138.8","Spermatogenic cell types":"63.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"16.0","Testicular Germ Cell Tumor (TCGA)":"7.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"4.5"},"RNA tissue cell type enrichment":["Adipose visceral - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 59: Pituitary endocrine cells - Neuroendocrine signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA043275":null,"HPA055678":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-3"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.70e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"}},{"Gene":"ZFTRAF1","Gene synonym":["CHRP","CYHR1","KIAA0496","MGC13010"],"Ensembl":"ENSG00000187954","Gene description":"Zinc finger TRAF-type containing 1","Uniprot":[],"Chromosome":"8","Position":"144449582-144462871","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"skeletal muscle":"9.2","testis":"9.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"59.9","Bergmann glia":"59.9","Brain excitatory neurons":"65.8","Brain inhibitory neurons":"59.2","Choroid plexus epithelial cells":"39.9","Distal convoluted tubule cells":"34.2","Ependymal cells":"51.1","Loop of henle epithelial cells":"23.8","Microglia":"40.2","Oligodendrocyte progenitor cells":"35.4","Oligodendrocytes":"47.4","Other brain neurons":"62.5","Papillary tip epithelial cells":"26.1","Podocytes":"25.6","Proximal tubule cells":"31.2","Renal collecting duct intercalated cells":"23.4","Renal collecting duct principal cells":"25.8","Renal connecting tubule cells":"26.7"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"14","RNA single cell type group specific nCPM":{"Ciliated cells":"51.1","Ductal cells":"26.7","Glial cells":"59.9","Neuronal cells":"65.8","Renal nephron cells":"34.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA053653":null,"HPA059543":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.21e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.44e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.41e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.64e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.61e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"1200000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 77: Intestine - Digestion","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 18: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 70: Intestinal goblet cells - Mucin production","Interactions":9,"Subcellular main location":["Annulus"],"Subcellular additional location":["Mid piece","Principal piece"],"Antibody RRID":{"HPA052066":null,"HPA052512":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-3"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZHX3","Gene synonym":["KIAA0395","TIX1"],"Ensembl":"ENSG00000174306","Gene description":"Zinc fingers and homeoboxes 3","Uniprot":["Q9H4I2"],"Chromosome":"20","Position":"41178448-41317731","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"630.5","Bergmann glia":"769.4","Loop of henle epithelial cells":"377.5","Proximal tubule cells":"454.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"769.4","Renal nephron cells":"454.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"785.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 44: Non-specific - Mixed function","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":9,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA046498":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA074045":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 5: Rhabdoid - Unknown function","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":32,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA071856":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 61: BICR 18 - Protein kinases","Single cell expression cluster":"Cluster 106: Spermatogonia - Spermatogonial differentiation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA034575":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 28: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 19: Non-specific - Unknown function","Single cell expression cluster":"Cluster 20: Non-specific - Transcription regulation","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Golgi apparatus"],"Antibody RRID":{"HPA015544":null,"HPA020879":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.96e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.02e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.73e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.64e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.68e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.54e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.91e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-1"}},{"Gene":"ZMYND10","Gene synonym":["BLU","CILD22","DNAAF7"],"Ensembl":"ENSG00000004838","Gene description":"Zinc finger MYND-type containing 10","Uniprot":["O75800"],"Chromosome":"3","Position":"50341110-50345732","Protein class":["Disease related genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Ciliopathy","Disease variant","Kartagener syndrome","Primary ciliary dyskinesia"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"choroid plexus":"80.2","fallopian tube":"113.1","testis":"226.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"129.3","Early spermatids":"234.5","Endometrial ciliated cells":"258.6","Ependymal cells":"149.8","Epididymal efferent duct ciliated cells":"465.0","Fallopian tube ciliated cells":"606.8","Late primary spermatocytes":"1156.1","Late spermatids":"649.7","Respiratory ciliated cells":"611.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"85","RNA single cell type group specific nCPM":{"Ciliated cells":"611.3","Spermatogenic cell types":"1156.1"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"ependymal cell":"205.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Uterine Corpus Endometrial Carcinoma (TCGA)":"24.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"NK-cell":"1.2"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":12,"Subcellular main location":["Plasma membrane","Basal body"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA035255":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.41e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.98e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.17e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-1"}},{"Gene":"ZMYND12","Gene synonym":["DKFZp434N2435"],"Ensembl":"ENSG00000066185","Gene description":"Zinc finger MYND-type containing 12","Uniprot":["Q9H0C1"],"Chromosome":"1","Position":"42430329-42456253","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"fallopian tube":"16.1","testis":"26.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"134.0","Endometrial ciliated cells":"31.6","Epididymal efferent duct ciliated cells":"39.0","Fallopian tube ciliated cells":"47.1","Late primary spermatocytes":"248.9","Late spermatids":"107.4","Respiratory ciliated cells":"53.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"248.9"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"35.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"prostate cancer":"1.6"},"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Liver - Hepatocytes","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"26242","Protein cell type specific Intensity":{"Fallopian tube cells":"2624226.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"151","Protein tissue specific Intensity":{"fallopian tube":"15143.0"},"Antibody":["HPA071608"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 60: Prostate cancer - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":66,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA071608":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.10e-3"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.80e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.53e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.13e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.50e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":null,"Subcellular main location":["Nuclear speckles"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023286":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.09e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.52e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.91e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.74e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.93e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-2"}},{"Gene":"ZNF100","Gene synonym":[],"Ensembl":"ENSG00000197020","Gene description":"Zinc finger protein 100","Uniprot":["Q8IYN0"],"Chromosome":"19","Position":"21722771-21767579","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"31.8","Bergmann glia":"43.8","Brain excitatory neurons":"28.7","Choroid plexus epithelial cells":"30.8","Distal convoluted tubule cells":"29.7","Early spermatids":"34.4","Ependymal cells":"36.0","Microglia":"93.6","Oligodendrocyte progenitor cells":"50.6","Oligodendrocytes":"52.1","Papillary tip epithelial cells":"33.7","Renal collecting duct intercalated cells":"38.4","Renal collecting duct principal cells":"41.5","Renal connecting tubule cells":"71.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"36.0","Ductal cells":"71.6","Glial cells":"93.6","Spermatogenic cell types":"34.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"12.5"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7378","Protein cell type specific Intensity":{"Granulosa cells":"737827.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059135"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059135":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.83e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.77e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.69e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.35e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.96e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"}},{"Gene":"ZNF101","Gene synonym":["DKFZp570I0164","HZF12"],"Ensembl":"ENSG00000181896","Gene description":"Zinc finger protein 101","Uniprot":["Q8IZC7"],"Chromosome":"19","Position":"19668796-19683509","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"25.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"67.5","T-cells":"47.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"67.5","T-cells":"47.3"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"24.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 31: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 51: Lymphoid tissue - Adaptive immune response","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 9: T-cells - Adaptive immunity: Regulation","Interactions":8,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023449":null,"HPA055486":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.57e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.20e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":46,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA031127":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - 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Breast glandular cells","Lung - Alveolar cells type 2","Minor Salivary Gland - Minor salivary glandular cells","Spleen - B-cells (Spleen)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA007247"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear speckles","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 23: Choroid plexus - Mixed function","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 30: Epididymal principal cells - Sperm storage microenvironment","Interactions":40,"Subcellular main location":["Nuclear speckles","Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA007247":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.13e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.02e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.14e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.76e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.28e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.99e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.61e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.10e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"}},{"Gene":"ZNF18","Gene synonym":["HDSG1","KOX11","Zfp535","ZKSCAN6","ZNF535","ZSCAN38"],"Ensembl":"ENSG00000154957","Gene description":"Zinc finger protein 18","Uniprot":["P17022"],"Chromosome":"17","Position":"11977439-11997475","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"40.0","Late spermatids":"42.4","Neutrophils":"28.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"42.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in all","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"testis cancer":"34.3"},"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA006144"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Plasma membrane","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 42: Non-specific - Unknown function","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":3,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Plasma membrane","Cytosol"],"Antibody RRID":{"HPA006144":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.47e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.86e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.51e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 103: Non-specific - Basic cellular processes","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA003226":null,"HPA064793":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-1"}},{"Gene":"ZNF19","Gene synonym":["KOX12","MGC51021"],"Ensembl":"ENSG00000157429","Gene description":"Zinc finger protein 19","Uniprot":["P17023"],"Chromosome":"16","Position":"71464555-71565089","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cholangiocytes":"64.3","Choroid plexus epithelial cells":"151.6","Ependymal cells":"224.0","Fallopian tube ciliated cells":"74.2","Respiratory ciliated cells":"185.0","Rod photoreceptor cells":"55.8","Somatotrophs":"60.5","Thyrotrophs":"58.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"224.0","Ductal cells":"64.3"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"choroid plexus epithelial cell":"142.5","ependymal cell":"241.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - Breast glandular cells","Breast - Breast glandular cells","Lung - Respiratory ciliated cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"706","Protein cell type specific Intensity":{"Pancreas epithelial cells":"70607.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA063685"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":24,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA063685":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.69e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.90e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.98e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.94e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.13e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.35e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"}},{"Gene":"ZNF20","Gene synonym":["KOX13"],"Ensembl":"ENSG00000132010","Gene description":"Zinc finger protein 20","Uniprot":["P17024"],"Chromosome":"19","Position":"12092843-12140355","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"32.2","Early spermatids":"49.8","Epicardial cells":"22.7","Epididymal efferent duct ciliated cells":"26.4","Late primary spermatocytes":"30.2","Late spermatids":"69.0","Respiratory ciliated cells":"31.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"31.3","Myocytes":"32.2","Spermatogenic cell types":"69.0"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"25.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 7: Non-specific - Innate immune response","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 50: Non-specific - Nucleic acid binding","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":43,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoplasm","Nuclear bodies"],"Antibody RRID":{"HPA020887":null,"HPA073206":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.41e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.14e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.68e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 4: Neutrophils - Degranulation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":2,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA018981":null,"HPA059310":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.01e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.99e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-1"}},{"Gene":"ZNF213","Gene synonym":["CR53","ZKSCAN21","ZSCAN53"],"Ensembl":"ENSG00000085644","Gene description":"Zinc finger protein 213","Uniprot":["O14771"],"Chromosome":"16","Position":"3129777-3142804","Protein class":["Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"83.7","Late spermatids":"110.0","Myonuclei":"177.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"177.1","Spermatogenic cell types":"110.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 36: Skeletal myocytes - Muscle excitation & contraction","Interactions":18,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA035000":null,"HPA056750":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.43e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Midbody"],"Antibody RRID":{"HPA055391":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.88e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - 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Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.96e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA004086":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.64e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.16e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.08e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.18e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.35e-5"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.72e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.85e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"}},{"Gene":"ZNF225","Gene synonym":[],"Ensembl":"ENSG00000256294","Gene description":"Zinc finger protein 225","Uniprot":["Q9UK10"],"Chromosome":"19","Position":"44112181-44134822","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"39.4","Late primary spermatocytes":"12.8","Retinal pigment epithelial cells":"12.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Myocytes":"39.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA073778":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.80e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 77: Late primary spermatocytes - Spermiogenesis: Golgi Phase","Interactions":8,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA030843":null,"HPA046679":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.06e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.84e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.30e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.60e-8"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.74e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.48e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.31e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-1"}},{"Gene":"ZNF273","Gene synonym":["HZF9"],"Ensembl":"ENSG00000198039","Gene description":"Zinc finger protein 273","Uniprot":["Q14593"],"Chromosome":"7","Position":"64870172-64930981","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"10.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Choroid plexus epithelial cells":"203.8","Ependymal cells":"321.1","Erythrocyte progenitors":"78.9","Fallopian tube ciliated cells":"81.7","Respiratory ciliated cells":"135.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Ciliated cells":"321.1"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"329.2"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"7.6"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"2.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Breast - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 2: Non-specific - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 34: Ciliated cells - Cilia assembly & function","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA077549":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.99e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane"],"Antibody RRID":{"HPA027307":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":21,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044373":null,"HPA077958":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.26e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.91e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.77e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.64e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.32e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.59e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.32e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"}},{"Gene":"ZNF330","Gene synonym":["HSA6591","NOA36"],"Ensembl":"ENSG00000109445","Gene description":"Zinc finger protein 330","Uniprot":["Q9Y3S2"],"Chromosome":"4","Position":"141220887-141234697","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Decidual stromal cells":"160.6","Early spermatids":"241.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"241.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - Neutrophils","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Hepatocytes":"257282.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"bone marrow":"771573.6","heart muscle":"767627.6"},"Antibody":["HPA015705","HPA056325"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoli","Plasma membrane","Primary cilium","Centrosome","Basal body","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 6: T-cells - T-cell receptor","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 22: Non-specific - mRNA splicing & Cell cycle","Single cell expression cluster":"Cluster 17: Non-specific - RNA processing","Interactions":50,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Plasma membrane","Primary cilium","Centrosome","Basal body","Cytosol"],"Antibody RRID":{"HPA015705":null,"HPA056325":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":26,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA051859":null,"HPA054738":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":7,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA052043":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA015319":null,"HPA015785":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.22e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 2: Neurons - Nucleosome","Cell line expression cluster":"Cluster 12: Bone cancer - Neuronal signaling","Single cell expression cluster":"Cluster 2: Cerebellar granular cells - Neuronal signaling","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA036190":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 65: Brain - Transcription","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 71: Lymphoma - Inflammatory response","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA050886":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA006686":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":25,"Subcellular main location":["Nucleoplasm","Nuclear membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA073151":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":12,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA003610":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.41e-5"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.86e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.11e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.59e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.36e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.20e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.49e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.20e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"}},{"Gene":"ZNF415","Gene synonym":[],"Ensembl":"ENSG00000170954","Gene description":"Zinc finger protein 415","Uniprot":["Q09FC8"],"Chromosome":"19","Position":"53107879-53133077","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"93.2","Late primary spermatocytes":"88.2","Late spermatids":"68.3"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"93.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatic stellate cells","Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA005553"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoli fibrillar center","Microtubules"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 35: Non-specific - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":2,"Subcellular main location":["Nucleoli fibrillar center","Microtubules"],"Subcellular additional location":null,"Antibody RRID":{"HPA005553":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.27e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.52e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.60e-4"},"Cancer prognostics - 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Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"47","Protein cell type specific Intensity":{"Granulosa cells":"4704.3"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059675"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 60: Cardiomyocytes - Cardiac muscle contraction & structure","Interactions":13,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA059675":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.00e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.33e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-6"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.76e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.85e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"}},{"Gene":"ZNF433","Gene synonym":["FLJ40981"],"Ensembl":"ENSG00000197647","Gene description":"Zinc finger protein 433","Uniprot":["Q8N7K0"],"Chromosome":"19","Position":"12014715-12035741","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"20.4"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"205.4","Late primary spermatocytes":"140.0","Late spermatids":"175.3","Oocytes":"46.1"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"205.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA073724"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nuclear bodies"],"Secretome location":"Intracellular and membrane","Secretome function":"Transcription","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 10: Non-specific - Membrane trafficking","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":9,"Subcellular main location":["Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA073724":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.99e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.73e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.38e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.43e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.63e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.75e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.16e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"}},{"Gene":"ZNF438","Gene synonym":["bA330O11.1"],"Ensembl":"ENSG00000183621","Gene description":"Zinc finger protein 438","Uniprot":["Q7Z4V0"],"Chromosome":"10","Position":"30820207-31031937","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"1433.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"1433.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - Endothelial cells","Prostate - Fibroblasts","Spleen - Neutrophils_2","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"100","Protein cell type specific Intensity":{"Pancreatic islets":"10039.7"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"202","Protein tissue specific Intensity":{"kidney":"20166.9"},"Antibody":["HPA039843"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Monocytes & Neutrophils - Degranulation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 14: Myeloid leukemia - Innate immune response","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":50,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039843":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.24e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.98e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.56e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 11: Esophagus - Basic cellular processes","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 107: Ciliated cells - Cilia assembly & function","Interactions":30,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047845":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.57e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.29e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.72e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.20e-5"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.40e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"}},{"Gene":"ZNF451","Gene synonym":["COASTER","dJ417I1.1","KIAA0576","KIAA1702","ZATT"],"Ensembl":"ENSG00000112200","Gene description":"Zinc finger protein 451","Uniprot":["Q9Y4E5"],"Chromosome":"6","Position":"57086844-57170305","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"66.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late spermatids":"660.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"660.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"2118369.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"2623740.6"},"Antibody":["HPA028838"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 18: Non-specific - Translation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 47: Leukemia - Hemostasis","Single cell expression cluster":"Cluster 18: Adrenal cortex cells - Steroidogensis","Interactions":14,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA028838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.96e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.60e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.14e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 32: Basophils - Transcription","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 46: Brainstem - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":17,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA004191":null,"HPA073309":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.22e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 3: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 72: Neuronal - Signal transduction","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":18,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA036594":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA059356":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.32e-4"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.35e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.87e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.37e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.24e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.52e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.01e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.34e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.58e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.61e-1"}},{"Gene":"ZNF487","Gene synonym":["KRBO1","ZNF487P"],"Ensembl":"ENSG00000243660","Gene description":"Zinc finger protein 487","Uniprot":[],"Chromosome":"10","Position":"43436841-43483181","Protein class":["Essential proteins","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":null,"NeXtProt evidence":null,"RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"26.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"235.8","Ependymal cells":"122.8","Late spermatids":"440.5","Respiratory ciliated cells":"146.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"146.0","Spermatogenic cell types":"440.5"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"ependymal cell":"131.2"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 28: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 56: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 17: Choroid plexus - Cilium","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nuclear membrane"],"Subcellular additional location":["Nucleoplasm","Cytosol"],"Antibody RRID":{"HPA037820":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 53: Neurons - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA058541":null,"HPA076453":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 28: Astrocytes - Homeostasis & neuron support","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA030838":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.87e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.55e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.68e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.33e-4"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":6,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA053956":null,"HPA055430":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.24e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.46e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.59e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.22e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.05e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.63e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.61e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-2"}},{"Gene":"ZNF563","Gene synonym":["FLJ34797"],"Ensembl":"ENSG00000188868","Gene description":"Zinc finger protein 563","Uniprot":["Q8TA94"],"Chromosome":"19","Position":"12317477-12333720","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"13.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"183.9","Late primary spermatocytes":"156.0","M\u00fcller glia":"42.6","Sertoli cells":"49.9"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"183.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"4","RNA blood lineage specific nTPM":{"B-cells":"4.2","T-cells":"8.9"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA042136":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.44e-4"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.11e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":1,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":null,"Antibody RRID":{"HPA044123":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.71e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":3,"Subcellular main location":["Nucleoplasm","Golgi apparatus","Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA052994":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.05e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.23e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.46e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":1,"Subcellular main location":["Intermediate filaments"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA042776":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.26e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 3: Early primary spermatocytes - Early meiosis","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"HPA023196":null,"HPA057274":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.89e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.72e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.51e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.36e-2"}},{"Gene":"ZNF578","Gene synonym":["FLJ31384"],"Ensembl":"ENSG00000258405","Gene description":"Zinc finger protein 578","Uniprot":["Q96N58"],"Chromosome":"19","Position":"52453553-52516882","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"5.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cone photoreceptor cells":"26.9","Differentiating spermatogonia":"22.3","Early spermatids":"76.7","Late primary spermatocytes":"35.6","Late spermatids":"61.1","Rod photoreceptor cells":"20.5","Undifferentiated spermatogonia":"32.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neuronal cells":"26.9","Spermatogenic cell types":"76.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"8","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"20.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 48: Ciliated tissues - Cilium organization","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":12,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.31e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.56e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 72: Kidney - Transmembrane transport","Brain expression cluster":"Cluster 31: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.72e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.56e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 46: Brain & retina - Neuronal signaling","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 56: Non-specific - Sensory perception","Single cell expression cluster":"Cluster 83: Epicardial mesothelial cells - Basic cellular functions","Interactions":1,"Subcellular main location":["Nucleoli","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA055463":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.39e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.81e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.41e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.62e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.01e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.31e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.02e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.13e-2"}},{"Gene":"ZNF599","Gene synonym":["FLJ30663"],"Ensembl":"ENSG00000153896","Gene description":"Zinc finger protein 599","Uniprot":["Q96NL3"],"Chromosome":"19","Position":"34758073-34773229","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"83.9","Epididymal efferent duct ciliated cells":"33.6","Epididymal principal cells":"33.5","Fallopian tube ciliated cells":"32.8","Late primary spermatocytes":"59.7","Late spermatids":"45.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"83.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 54: Immune cells - T cell receptor","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":7,"Subcellular main location":["Plasma membrane","Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA014701":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.43e-5"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 92: NK-cells & T-cells - Adaptive immunity: Cytotoxicity","Interactions":22,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA040742":null,"HPA040832":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.82e-3"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.28e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"}},{"Gene":"ZNF610","Gene synonym":["FLJ36040"],"Ensembl":"ENSG00000167554","Gene description":"Zinc finger protein 610","Uniprot":["Q8N9Z0"],"Chromosome":"19","Position":"52336243-52367778","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"44.0","Late primary spermatocytes":"26.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"44.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"15.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Colon - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.56e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Vesicles","Cytosol"],"Antibody RRID":{"HPA021197":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.69e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.07e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.38e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.01e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-1"}},{"Gene":"ZNF622","Gene synonym":["MGC17552","MGC2485","ZPR9"],"Ensembl":"ENSG00000173545","Gene description":"Zinc finger protein 622","Uniprot":["Q969S3"],"Chromosome":"5","Position":"16451519-16465800","Protein class":["Predicted intracellular proteins"],"Biological process":["Ribosome biogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"147.6"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"1790136.2","T-cells":"1855172.8"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lymphoid tissue":"6202599.5"},"Antibody":["HPA036514","HPA036515"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nucleoli","Golgi apparatus","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 29: Non-specific - Unknown function","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":26,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Nucleoli","Golgi apparatus"],"Antibody RRID":{"HPA036514":null,"HPA036515":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.15e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.75e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.55e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.92e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.14e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.74e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.23e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.97e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-1"}},{"Gene":"ZNF628","Gene synonym":["ZEC","Zfp628"],"Ensembl":"ENSG00000197483","Gene description":"Zinc finger protein 628","Uniprot":["Q5EBL2"],"Chromosome":"19","Position":"55476617-55484487","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"21.8"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Late spermatids":"212.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"10","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"212.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"91","Protein cell type specific Intensity":{"Granulosa cells":"9052.1"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044451"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044451":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.64e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.30e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.37e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.02e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 47: Testis - Mixed function","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 31: Neutrophils - Chemotaxis & Apoptosis","Interactions":4,"Subcellular main location":["Nucleoplasm","Plasma membrane","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA042364":null,"HPA066468":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.79e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.95e-6"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - 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Minor salivary glandular cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"139","Protein cell type specific Intensity":{"Granulosa cells":"15207.2","Neurons":"12574.2"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"66","Protein tissue specific Intensity":{"intestine":"6558.3"},"Antibody":["HPA023631","HPA023635"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 23: Non-specific - Transcription","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":5,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA023631":null,"HPA023635":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.78e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.86e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.83e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.94e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.90e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.76e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.48e-1"}},{"Gene":"ZNF664","Gene synonym":["DKFZp761B128","ZFOC1","ZNF176"],"Ensembl":"ENSG00000179195","Gene description":"Zinc finger protein 664","Uniprot":["Q8N3J9"],"Chromosome":"12","Position":"123971845-124015439","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"35.9","Late spermatids":"63.7"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"5","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"63.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 3: Oligodendrocytes - Myelination","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 38: Non-specific - Transcription","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":4,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047846":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.84e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.60e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.47e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.56e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.58e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"}},{"Gene":"ZNF669","Gene synonym":["FLJ12606"],"Ensembl":"ENSG00000188295","Gene description":"Zinc finger protein 669","Uniprot":["Q96BR6"],"Chromosome":"1","Position":"247099962-247104372","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"B-cells":"21.2"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA044043"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 45: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 87: B-cells - Adaptive immunity: Humoral response","Interactions":19,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA044043":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.84e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.45e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.78e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.61e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.24e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.82e-2"}},{"Gene":"ZNF675","Gene synonym":["TBZF","TIZ"],"Ensembl":"ENSG00000197372","Gene description":"Zinc finger protein 675","Uniprot":["Q8TD23"],"Chromosome":"19","Position":"23525631-23687220","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"109.5","Late primary spermatocytes":"111.7","Late spermatids":"305.8","Renal collecting duct principal cells":"86.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"305.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"37.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 48: Non-specific - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 109: Neurons - Neuronal signaling","Interactions":4,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.67e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.03e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.41e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.83e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.98e-4"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.45e-2"}},{"Gene":"ZNF677","Gene synonym":["MGC48625"],"Ensembl":"ENSG00000197928","Gene description":"Zinc finger protein 677","Uniprot":["Q86XU0"],"Chromosome":"19","Position":"53235381-53254898","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"42.4"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"783.5","Late primary spermatocytes":"198.5","Late spermatids":"538.5"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"783.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Spleen - Endothelial cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023106"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Centrosome"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 55: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 90: Elongating spermatids - Spermiogenesis: Elongation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Centrosome"],"Antibody RRID":{"HPA023106":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.19e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.19e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.16e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.59e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.01e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.71e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.75e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.30e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.70e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.86e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-1"}},{"Gene":"ZNF683","Gene synonym":["Hobit","MGC33414"],"Ensembl":"ENSG00000176083","Gene description":"Zinc finger protein 683","Uniprot":["Q8IZ20"],"Chromosome":"1","Position":"26361634-26374522","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Adaptive immunity","Host-virus interaction","Immunity","Innate immunity","Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"8","RNA tissue specific nTPM":{"testis":"76.5"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Early spermatids":"640.0","Late spermatids":"639.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"21","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"640.0"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in single","RNA single nuclei brain specificity score":"67","RNA single nuclei brain specific nCPM":{"leukocyte":"46.4"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"11.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"gdT-cell":"172.8","memory CD8 T-cell":"113.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"15","RNA blood lineage specific nTPM":{"T-cells":"172.8"},"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in single","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Leukemia":"2.2"},"RNA tissue cell type enrichment":["Adipose subcutaneous - T-cells","Adipose visceral - T-cells","Breast - T-cells","Kidney - T-cells","Lung - T-cells","Pancreas - T-cells","Testis - Early spermatids","Testis - Late spermatids","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA023865"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 1: T-cells - Unknown function","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 59: Leukemia - T-cell receptor","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":5,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA023865":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.40e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.09e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.64e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.81e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.61e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.18e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.89e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-2"}},{"Gene":"ZNF689","Gene synonym":["FLJ90415","TIPUH1"],"Ensembl":"ENSG00000156853","Gene description":"Zinc finger protein 689","Uniprot":["Q96CS4"],"Chromosome":"16","Position":"30602558-30624012","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"18.2"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Breast hormone-responsive cells":"55.2","Early spermatids":"44.6","Late primary spermatocytes":"151.7","Late spermatids":"83.1","Oocytes":"46.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Luminal cells":"55.2","Spermatogenic cell types":"151.7"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Group enriched","Protein cell type distribution":"Detected in some","Protein cell type specificity score":"1960","Protein cell type specific Intensity":{"Granulosa cells":"79180.7","Oocytes":"312766.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA054095","HPA055385"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli fibrillar center"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 33: Non-specific - ATP binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 54: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":8,"Subcellular main location":["Nucleoplasm","Nucleoli fibrillar center"],"Subcellular additional location":null,"Antibody RRID":{"HPA054095":null,"HPA055385":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.53e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.80e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.34e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.96e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.49e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.89e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.03e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.15e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.94e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.32e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.74e-1"}},{"Gene":"ZNF692","Gene synonym":["AREBP","FLJ20531","Zfp692"],"Ensembl":"ENSG00000171163","Gene description":"Zinc finger protein 692","Uniprot":["Q9BU19"],"Chromosome":"1","Position":"248850006-248859144","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"76.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"76.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA059337","HPA062792"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Nucleoli"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 14: Non-specific - Unknown function","Tissue expression cluster":"Cluster 64: Non-specific - Transcription","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 35: RS4;11 - Unknown function","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":4,"Subcellular main location":["Nucleoplasm","Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA059337":null,"HPA062792":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.68e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.97e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.18e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.88e-5"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.65e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.05e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.92e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.94e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"}},{"Gene":"ZNF705A","Gene synonym":["FLJ16353"],"Ensembl":"ENSG00000196946","Gene description":"Zinc finger protein 705A","Uniprot":["Q6ZN79"],"Chromosome":"12","Position":"8157015-8188537","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in some","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"epididymis":"2.2"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"8","RNA single cell type specific nCPM":{"Early spermatids":"6.0","Late primary spermatocytes":"2.3","Late spermatids":"3.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"6.0"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Glioblastoma Multiforme (TCGA)":"2.8","Ovary Serous Cystadenocarcinoma (TCGA)":"1.4","Testicular Germ Cell Tumor (TCGA)":"1.1"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in many","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"192","Protein tissue specific Intensity":{"intestine":"19249.5"},"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 51: Neurons - Mixed function","Cell line expression cluster":"Cluster 27: Breast cancer - Unknown function","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.92e-1"},"Cancer prognostics - 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Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.95e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZNF706","Gene synonym":["HSPC038"],"Ensembl":"ENSG00000120963","Gene description":"Zinc finger protein 706","Uniprot":["Q9Y5V0"],"Chromosome":"8","Position":"101177878-101206193","Protein class":["Predicted intracellular proteins"],"Biological process":["Translation regulation"],"Molecular function":["Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"836.0","Esophageal suprabasal cells":"829.9","Late spermatids":"1689.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"1689.0"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"2335871.9"},"Antibody":["HPA042793"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 40: Non-specific - Unknown function","Single cell expression cluster":"Cluster 85: Squamous epithelial cells - Keratinization","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"HPA042793":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.53e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.18e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.07e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.48e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.85e-7"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.77e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.20e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.59e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.75e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.49e-4"}},{"Gene":"ZNF709","Gene synonym":["FLJ38281"],"Ensembl":"ENSG00000242852","Gene description":"Zinc finger protein 709","Uniprot":["Q8N972"],"Chromosome":"19","Position":"12461184-12513854","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in many","RNA tissue specificity score":"5","RNA tissue specific nTPM":{"testis":"14.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"5","RNA single cell type specific nCPM":{"Early spermatids":"28.9","Late spermatids":"24.2"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":"36","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"28.9"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA045573":null,"HPA053153":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.53e-2"},"Cancer prognostics - 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Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.88e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"4.77e-8"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.70e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.83e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.60e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.62e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.97e-2"}},{"Gene":"ZNF713","Gene synonym":["FLJ39963"],"Ensembl":"ENSG00000178665","Gene description":"Zinc finger protein 713","Uniprot":["Q8N859"],"Chromosome":"7","Position":"55887456-55942530","Protein class":["Disease related genes","Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":["Autism spectrum disorder"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"22.2","Bergmann glia":"25.6","Brain excitatory neurons":"23.0","Brain inhibitory neurons":"28.9","Choroid plexus epithelial cells":"43.1","Ependymal cells":"59.2","Microglia":"13.0","Oligodendrocyte progenitor cells":"30.2","Oligodendrocytes":"47.4","Other brain neurons":"21.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"9","RNA single cell type group specific nCPM":{"Ciliated cells":"59.2","Glial cells":"47.4","Neuronal cells":"28.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"2.8"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"2.8"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 20: Non-specific - DNA binding","Tissue expression cluster":"Cluster 40: Non-specific - Mixed function","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 22: Non-specific - Basic cellular functions","Interactions":1,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA059425":null,"HPA062887":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.93e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.24e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.29e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.25e-2"},"Cancer prognostics - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 106: Spermatogonia - Spermatogonial differentiation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZNF723","Gene synonym":["ZNF723P"],"Ensembl":"ENSG00000268696","Gene description":"Zinc finger protein 723","Uniprot":["P0DPD5"],"Chromosome":"19","Position":"22832291-22858667","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"No human protein\/transcript evidence","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"9","RNA tissue specific nTPM":{"testis":"3.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Differentiating spermatogonia":"12.4","Early primary spermatocytes":"31.3","Early spermatids":"58.8","Late primary spermatocytes":"18.0","Oocytes":"4.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"12","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"58.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"6","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"12.1"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 46: Basophils - Proteolysis","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.50e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.45e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.36e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZNF746","Gene synonym":["FLJ31413","PARIS"],"Ensembl":"ENSG00000181220","Gene description":"Zinc finger protein 746","Uniprot":["Q6NUN9"],"Chromosome":"7","Position":"149472696-149497817","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding","Repressor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Neutrophils":"109.4"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Neutrophils":"109.4"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"7.0"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"granulocytes":"7.0"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 67: Testis - Mixed function","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 24: Neutrophils - Innate immunity signal integration","Interactions":14,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA020272":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.71e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.66e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Unknown function","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":2,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA047845":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.50e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 6: Non-specific - Immune response","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":5,"Subcellular main location":["Centrosome"],"Subcellular additional location":null,"Antibody RRID":{"HPA044882":null,"HPA063496":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.95e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.05e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.29e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.87e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.00e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.12e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.24e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.15e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.07e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.50e-2"}},{"Gene":"ZNF782","Gene synonym":["FLJ16636"],"Ensembl":"ENSG00000196597","Gene description":"Zinc finger protein 782","Uniprot":["Q6ZMW2"],"Chromosome":"9","Position":"96816269-96875623","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 3: Non-specific - Nuclear processes","Tissue expression cluster":"Cluster 42: Retina - Visual perception","Brain expression cluster":"Cluster 15: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":null,"Subcellular main location":["Nucleoplasm","Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA011013":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.10e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 43: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":7,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA028977":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.78e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.36e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.21e-2"}},{"Gene":"ZNF790","Gene synonym":["FLJ20350","MGC62100"],"Ensembl":"ENSG00000197863","Gene description":"Zinc finger protein 790","Uniprot":["Q6PG37"],"Chromosome":"19","Position":"36817428-36850787","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"100.2","Early spermatids":"184.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Spermatogenic cell types":"184.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 71: Non-specific - Cardiac endocrine signaling & maintenanc","Interactions":null,"Subcellular main location":["Nucleoli"],"Subcellular additional location":null,"Antibody RRID":{"HPA056134":null,"HPA060288":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.65e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.95e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.99e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.12e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.33e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.50e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.31e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.65e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.73e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-1"}},{"Gene":"ZNF800","Gene synonym":[],"Ensembl":"ENSG00000048405","Gene description":"Zinc finger protein 800","Uniprot":["Q2TB10"],"Chromosome":"7","Position":"127346790-127431924","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"bone marrow":"70.4"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 44: Bone marrow - Nuclear processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 39: Non-specific - Transcription","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":2,"Subcellular main location":["Nucleoli","Nucleoli rim"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA023090":null,"HPA052194":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.39e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.04e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.75e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.08e-7"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.35e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.81e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.90e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.63e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.86e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.28e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.83e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.68e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.28e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.51e-1"}},{"Gene":"ZNF821","Gene synonym":[],"Ensembl":"ENSG00000102984","Gene description":"Zinc finger protein 821","Uniprot":["O75541"],"Chromosome":"16","Position":"71859680-71895336","Protein class":["Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"25.3","testis":"19.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"183.5","Enterocytes":"193.7","Late primary spermatocytes":"198.1"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Enterocytes":"193.7","Spermatogenic cell types":"198.1"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":"4","RNA blood cell specific nTPM":{"memory B-cell":"9.5","naive B-cell":"13.5","T-reg":"5.7"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"B-cells":"13.5","T-cells":"5.7"},"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 71: Cerebellum - Nervous system development","Brain expression cluster":"Cluster 35: Non-specific - DNA binding","Cell line expression cluster":"Cluster 68: Non-specific - Cell cycle regulation","Single cell expression cluster":"Cluster 65: Non-specific - Cell growth & division","Interactions":2,"Subcellular main location":["Nucleoplasm","Nuclear speckles"],"Subcellular additional location":null,"Antibody RRID":{"HPA036372":null,"HPA042742":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"9.17e-10"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.95e-5"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.14e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.83e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - 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Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.79e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.18e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.44e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"}},{"Gene":"ZNF829","Gene synonym":["DKFZp779O175"],"Ensembl":"ENSG00000185869","Gene description":"Zinc finger protein 829","Uniprot":["Q3KNS6"],"Chromosome":"19","Position":"36888124-36916291","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"testis":"6.2"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"335.9"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"335.9"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"6.9"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA073073"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 33: Early spermatids - Spermiogenesis: Cap phase","Interactions":6,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Nuclear bodies"],"Antibody RRID":{"HPA073073":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.72e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.49e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.74e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.29e-4"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.80e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.04e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.31e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.69e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.87e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.72e-1"}},{"Gene":"ZNF839","Gene synonym":["C14orf131"],"Ensembl":"ENSG00000022976","Gene description":"Zinc finger protein 839","Uniprot":["A8K0R7"],"Chromosome":"14","Position":"102317377-102342702","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Late primary spermatocytes":"54.3","Myonuclei":"49.9"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 30: Non-specific - DNA binding","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 56: Hypothalamus - Neuropeptide signaling","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 7: Non-specific - Transcription","Interactions":null,"Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA020434":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.86e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.37e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.72e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 10: Cerebellum - Nucleic acid binding","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA044760":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.89e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"9863","Protein cell type specific Intensity":{"Fallopian tube cells":"986326.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA068608"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":null,"Antibody RRID":{"HPA068608":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.28e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.40e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.62e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.23e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.15e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.26e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.55e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.57e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.75e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-2"}},{"Gene":"ZNFX1","Gene synonym":["FLJ11277","KIAA1404"],"Ensembl":"ENSG00000124201","Gene description":"Zinc finger NFX1-type containing 1","Uniprot":["Q9P2E3"],"Chromosome":"20","Position":"49237946-49278426","Protein class":["Disease related genes","Plasma proteins","Predicted intracellular proteins","Transcription factors"],"Biological process":["Antiviral defense","Immunity","Innate immunity"],"Molecular function":["RNA-binding"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophils":"311.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"311.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"1","Protein tissue specific Intensity":{"cerebral cortex":"2887546.1"},"Antibody":["HPA046629"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"No","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 35: Neutrophils - Protein binding","Tissue expression cluster":"Cluster 14: Adipose tissue - Angiogenesis","Brain expression cluster":"Cluster 43: Hindbrain - Mixed function","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 29: Neutrophils - Innate immune cellular maintenance","Interactions":18,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA046629":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.18e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.52e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.54e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.50e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.02e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.89e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.12e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.97e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.03e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.07e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.12e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.94e-3"}},{"Gene":"ZNHIT3","Gene synonym":["Hit1","TRIP3"],"Ensembl":"ENSG00000273611","Gene description":"Zinc finger HIT-type containing 3","Uniprot":["Q15649"],"Chromosome":"17","Position":"36486629-36499310","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant","Epilepsy","Intellectual disability","Neurodegeneration"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"11.6","Bergmann glia":"15.6","Brain excitatory neurons":"19.8","Brain inhibitory neurons":"17.8","Choroid plexus epithelial cells":"8.5","Epicardial cells":"9.1","Loop of henle epithelial cells":"9.0","Microglia":"12.2","Oligodendrocyte progenitor cells":"14.3","Oligodendrocytes":"21.5","Other brain neurons":"21.8","Papillary tip epithelial cells":"8.4","Parietal cells":"8.8","Renal collecting duct principal cells":"9.0"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"21.5","Neuronal cells":"21.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Group enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":"36","Protein tissue specific Intensity":{"bone marrow":"5507.1","fallopian tube":"1625.2"},"Antibody":["HPA060019","HPA078211"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 43: Non-specific - Transcription & Translation","Tissue expression cluster":"Cluster 25: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 98: Neurons - Neurotransmission & signaling","Interactions":9,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA060019":null,"HPA078211":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.44e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.13e-4"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.08e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.49e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.37e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.14e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.41e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 24: Non-specific - Transcription","Brain expression cluster":"Cluster 32: Cerebral cortex - Mixed function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 97: Non-specific - Cellular respiration","Interactions":100,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039789":null,"HPA064670":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.67e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.88e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.39e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.06e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.66e-3"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 13: Non-specific - Mitochondria","Tissue expression cluster":"Cluster 26: Kidney & Intestine - Metabolism","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 67: Non-specific - Unknown function","Single cell expression cluster":"Cluster 74: Microglia - Neuroimmunity & neuroinflammation","Interactions":15,"Subcellular main location":["Nucleoplasm","Vesicles"],"Subcellular additional location":["Nucleoli fibrillar center"],"Antibody RRID":{"HPA072244":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.41e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.21e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.89e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.33e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.27e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.45e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.57e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":null,"Cell line expression cluster":"Cluster 10: Ciliated cells - Ion channel activity","Single cell expression cluster":"Cluster 56: Late spermatids - Spermiogenesis: Maturation","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.14e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - 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Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZPBP","Gene synonym":["SP38","ZPBP1"],"Ensembl":"ENSG00000042813","Gene description":"Zona pellucida binding protein","Uniprot":["Q9BS86"],"Chromosome":"7","Position":"49850421-50121329","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"31","RNA tissue specific nTPM":{"testis":"133.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"979.3","Early primary spermatocytes":"296.2","Early spermatids":"927.3","Late primary spermatocytes":"1733.7","Retinal bipolar cells":"795.2","Retinal ganglion cells":"170.0","Rod photoreceptor cells":"655.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"22","RNA single cell type group specific nCPM":{"Myocytes":"979.3","Neuronal cells":"795.2","Spermatogenic cell types":"1733.7"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"LAMP5-LHX6 and Chandelier":"55.5"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 57: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 86: Retinal bipolar cells - Synaptic signal transduction","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA058673":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - 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Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA027997","HPA053070"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted in male reproductive system","Secretome function":"No annotated function","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 6: Testis - Spermatogenesis","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 46: Lymphoma - Humoral immune response","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA027997":null,"HPA053070":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - 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Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"ZPR1","Gene synonym":["ZNF259"],"Ensembl":"ENSG00000109917","Gene description":"ZPR1 zinc finger","Uniprot":["O75312"],"Chromosome":"11","Position":"116773799-116788039","Protein class":["Disease related genes","Essential proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":["Deafness","Dwarfism","Hypotrichosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"225.7","Late primary spermatocytes":"204.7","Late spermatids":"624.6"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":"8","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"624.6"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Granulosa cells":"3169488.9"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["CAB022596","HPA030979"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 25: Non-specific - Unknown function","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 24: Non-specific - Unknown function","Single cell expression cluster":"Cluster 73: Late spermatids - Spermiogenesis: Maturation","Interactions":2,"Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB022596":null,"HPA030979":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.21e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.17e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"3.03e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.31e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.46e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.73e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.49e-4"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.20e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.23e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.63e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.05e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.83e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.20e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.30e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.34e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"}},{"Gene":"ZRANB1","Gene synonym":["TRABID"],"Ensembl":"ENSG00000019995","Gene description":"Zinc finger RANBP2-type containing 1","Uniprot":["Q9UGI0"],"Chromosome":"10","Position":"124942123-124988189","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Ubl conjugation pathway","Wnt signaling pathway"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Neutrophil progenitors":"220.1","Neutrophils":"276.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"276.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 63: Non-specific - Basic cellular processes","Brain expression cluster":"Cluster 16: Non-specific - Transcription","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":345,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA029239":null,"HPA029240":null,"HPA029241":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.95e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"6.93e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.48e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.13e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.47e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 22: Epididymis - Mixed function","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 4: Non-specific - Transcription","Single cell expression cluster":"Cluster 10: Epididymal principal cells - Sperm maturation microenvironment","Interactions":3,"Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"HPA007938":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.79e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - 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Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.78e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.20e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.90e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.34e-3"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"}},{"Gene":"ZSCAN2","Gene synonym":["FLJ20595","ZFP29","ZNF854"],"Ensembl":"ENSG00000176371","Gene description":"Zinc finger and SCAN domain containing 2","Uniprot":["Q7Z7L9"],"Chromosome":"15","Position":"84600986-84627796","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Differentiation","Spermatogenesis","Transcription","Transcription regulation"],"Molecular function":["Developmental protein","DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Adipocytes":"23.0","Cardiomyocytes":"30.3","Late primary spermatocytes":"25.4","Pancreatic acinar cells":"31.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 42: Non-specific - Vesicular transport","Tissue expression cluster":"Cluster 8: Pancreas - Proteolysis","Brain expression cluster":"Cluster 25: Non-specific - Transcription","Cell line expression cluster":"Cluster 6: Leukemia - Signal transduction","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":null,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA007296":null,"HPA024331":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.74e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"3.20e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.14e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.07e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.51e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.58e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.67e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.98e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.29e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.33e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.62e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-2"}},{"Gene":"ZSCAN29","Gene synonym":["FLJ35867","Zfp690","ZNF690"],"Ensembl":"ENSG00000140265","Gene description":"Zinc finger and SCAN domain containing 29","Uniprot":["Q8IWY8"],"Chromosome":"15","Position":"43358172-43371043","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nCPM":{"Early spermatids":"131.8"},"RNA single cell type group specificity":"Cell type enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"4","RNA single cell type group specific nCPM":{"Spermatogenic cell types":"131.8"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"eosinophil":"3.0"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Testis - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: Eosinophils - Transcription","Tissue expression cluster":"Cluster 61: Non-specific - Transcription","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 42: Early spermatids - Spermiogenesis: Acrosomal phase","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Plasma membrane","Actin filaments"],"Antibody RRID":{"HPA007241":null,"HPA011109":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.77e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 24: Non-specific - Transcription","Tissue expression cluster":"Cluster 21: Testis - Mixed function","Brain expression cluster":"Cluster 34: Non-specific - Mixed function","Cell line expression cluster":"Cluster 7: Liver cancer - Metabolism","Single cell expression cluster":"Cluster 55: Myocytes - Oxidative muscle function","Interactions":3,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA007124":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.95e-6"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.79e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.44e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.46e-2"},"Cancer prognostics - 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Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.27e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.53e-3"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.11e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.76e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.84e-2"}},{"Gene":"ZSCAN9","Gene synonym":["PRD51","ZNF193"],"Ensembl":"ENSG00000137185","Gene description":"Zinc finger and SCAN domain containing 9","Uniprot":["O15535"],"Chromosome":"6","Position":"28224886-28233487","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Transcription","Transcription regulation"],"Molecular function":["DNA-binding"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":null,"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Minor Salivary Gland - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.64e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.68e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.47e-5"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.52e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.04e-2"},"Cancer prognostics - 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Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Adrenal gland - Adrenal medulla cells","Breast - Adipocytes (Breast)","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"32","Protein cell type specific Intensity":{"Distal tubules":"3247.6"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 21: Non-specific - Metabolism","Cell line expression cluster":"Cluster 58: Non-specific - Nuclear processes","Single cell expression cluster":"Cluster 53: Late primary spermatocytes - Meiotic division & transition","Interactions":2,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.34e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.70e-1"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.63e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.23e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.54e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"1.40e-4"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.29e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.46e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.26e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.97e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.20e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-2"},"Cancer prognostics - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 12: Non-specific - Mitochondrial translation","Tissue expression cluster":"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation","Brain expression cluster":"Cluster 38: Sub-cortical - Mixed function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 27: Non-specific - Cell proliferation","Interactions":58,"Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA005757":null,"HPA022264":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.15e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.13e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.07e-2"},"Cancer prognostics - 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Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.21e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.94e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.93e-9"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.02e-5"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"7.09e-5"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"5.54e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.25e-4"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.84e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.49e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.54e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.82e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.25e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.63e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.13e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.24e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.59e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"}}]